CN111803415A - Plant essential oil nano emulsion, preparation method thereof and application thereof in lip products - Google Patents

Plant essential oil nano emulsion, preparation method thereof and application thereof in lip products Download PDF

Info

Publication number
CN111803415A
CN111803415A CN202010686317.0A CN202010686317A CN111803415A CN 111803415 A CN111803415 A CN 111803415A CN 202010686317 A CN202010686317 A CN 202010686317A CN 111803415 A CN111803415 A CN 111803415A
Authority
CN
China
Prior art keywords
oil
essential oil
percent
plant essential
lip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202010686317.0A
Other languages
Chinese (zh)
Other versions
CN111803415B (en
Inventor
秦艳
黄玲
王娜
钟锐文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Alchem Biotechnology Co ltd
Original Assignee
Guangzhou Alchem Biotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Alchem Biotechnology Co ltd filed Critical Guangzhou Alchem Biotechnology Co ltd
Priority to CN202010686317.0A priority Critical patent/CN111803415B/en
Publication of CN111803415A publication Critical patent/CN111803415A/en
Application granted granted Critical
Publication of CN111803415B publication Critical patent/CN111803415B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • A61K8/064Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • A61K8/068Microemulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02Preparations containing skin colorants, e.g. pigments
    • A61Q1/04Preparations containing skin colorants, e.g. pigments for lips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02Preparations containing skin colorants, e.g. pigments
    • A61Q1/04Preparations containing skin colorants, e.g. pigments for lips
    • A61Q1/06Lipsticks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/001Preparations for care of the lips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30Characterized by the absence of a particular group of ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/413Nanosized, i.e. having sizes below 100 nm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84Products or compounds obtained by lyophilisation, freeze-drying

Abstract

The invention discloses a plant essential oil nano-emulsion, a preparation method thereof and application thereof in lip products; the plant essential oil composition consists of an emulsifier, a water phase and an oil phase; taking magnolia extract and deionized water as water phases; the oil phase comprises the following components in percentage by mass: 40.0 to 70.0 percent of cocoa butter, 10.0 to 25.0 percent of avocado oil, 5.0 to 15.0 percent of sweet almond oil, 5.0 to 10.0 percent of coconut oil, 5.0 to 10.0 percent of safflower seed oil and 3.0 to 6.0 percent of rose essential oil; the plant essential oil treated by the method has increased transdermal absorption speed, the magnolia flower extract added in the water phase can promote the plant essential oil to permeate the skin, when the lip product prepared by adopting the plant nano essential oil is applied to lips, the retention time of oily substances on the surface of the skin is reduced, the product absorption speed is high, and the product is fresh and non-greasy after being used.

Description

Plant essential oil nano emulsion, preparation method thereof and application thereof in lip products
Technical Field
The invention relates to the field of cosmetics, and in particular relates to plant essential oil nano emulsion, a preparation method thereof and application thereof in lip products.
Background
The lips are also the pronouncing words of female sexual feeling, and the clear, moist and full lips can make the appearance of women more beautiful and increase the charm index, so that the care of the lips is very important for women.
At present, a plurality of lip care products are available on the market, including lipstick, lip glaze, lip honey, lip gel and the like, the products are prepared by adopting chemical components, the skin is easy to be irritated, skin allergy is caused, and in severe cases, the chemical components can enter the body through pores of the human body and cause harm to the human body to a certain extent. In addition, many products have some disadvantages in use, such as poor moisturizing effect, heavy greasy feeling in use, poor refreshing, and the like.
Chinese patent application 201810401018.0 discloses a refreshing lipstick, which is prepared from the following raw materials in parts by weight: 15-20 parts of willow leaf powder, 20-30 parts of olive oil, 7-10 parts of aloe gel juice, 12-15 parts of watermelon peel powder, 10-30 parts of beeswax, 5-10 parts of okra powder, 10-15 parts of shark liver oil, 10-14 parts of glycerin, 4-6 parts of lanolin and 0.1-0.3 part of gastrodin. The technology does not contain essence, pigment, antiseptic, etc., has good moisturizing effect on lips, and can prevent lip chap. The technology comprises plant powder (willow leaf powder, watermelon peel powder and okra powder), oily components (olive oil, shark liver oil and wool fat), water-soluble components (aloe gel juice, glycerin and gastrodin) and beeswax, and no emulsifier or surfactant is used in the technology, so that the lipstick prepared by the technology cannot be uniformly mixed together as common knowledge, and the large component of the plant powder is cellulose and cannot be uniformly dissolved in oil or water, so that the effects of the technology on moisturizing and lip skin improvement are to be improved.
Chinese patent application 201910467104.6 discloses a pure natural moisturizing lip balm, which consists of the following components: 5-15 wt% of shea butter, 2-10 wt% of jojoba oil, 2-10 wt% of grape seed oil, 10-20 wt% of sweet almond oil, 20-40 wt% of olive oil, 0.01-0.1 wt% of traditional Chinese medicine extract, 10-20 wt% of beeswax, 2-10 wt% of candelilla wax, 0.001-0.01 wt% of vitamin E and 0.001-0.01 wt% of plant essential oil. The invention provides a pure natural moistening and moisturizing lipstick, which is characterized in that moistening and moisturizing components, flavoring components, antioxidant components, antiseptic components and bacteriostatic components are all from natural plants, so that the effect is ensured, and no chemical additive is ensured. However, the lipstick prepared by the technology has high content of oily components, and the lipstick is not processed at all during preparation, so that the prepared lipstick is greasy and not refreshing after being applied.
In addition, in recent years, with the improvement of quality of life and the increasing of health care consciousness, the safety of chemical products is greatly concerned by consumers, and people are in need of pursuing again natural, green and non-toxic side effects and having multiple physiological and nutritional effects, more and more skin care products are developed, and especially plant extract skin care products with small side effects and less toxicity are more and more favored by people. Therefore, the development of plant resource active substances and the development of pure natural cosmetics have become one of the most active subjects for the development of the cosmetic industry.
Disclosure of Invention
The invention aims to provide a plant essential oil nano emulsion, a preparation method thereof and application thereof in lip products according to the defects in the prior art. The plant essential oil nanoemulsion is prepared from natural plant raw materials, has the advantages of high permeation speed, greenness and safety, and lip products prepared from the plant essential oil nanoemulsion have the characteristics of good moisturizing effect, capability of rapidly permeating skin, freshness and non-greasiness after use; fragrant smell, mild texture and no irritation.
The invention provides a plant essential oil composition, which comprises cacao butter, avocado oil, sweet almond oil, coconut oil, safflower seed oil and rose essential oil. The cocoa butter is base oil with strong permeability, contains rich vitamin E, is the same as the secretion of natural sebum of a human body, is easy to be absorbed by skin, is fresh and moist, is not greasy, effectively regulates the secretion function of sebaceous glands, and is the best skin moisturizing oil. The oil film formed by the method is different from mineral oil, and not only can permeate evaporated moisture, but also can control the loss of the moisture.
Avocado oil has a sweet fruit flavor with a somewhat greasy feel and a fruity taste. Has high nutrition, and belongs to base oil penetrating deeper. The skin care product has rapid skin penetration capacity, the penetration capacity of the skin care product is second to that of the cocoa butter, and the skin care product can not only help the skin of the epidermis, but also deeply reach the bottom layer of the skin, help the restoration and regeneration functions of cells and delay the aging speed of the skin.
Sweet almond oil has excellent extensibility, is rich in nourishing components, is extremely mild, can be used by infants with the most delicacy, and can be mutually blended with any vegetable oil. Sweet almond oil has excellent repairing effect, can promote cell growth, is suitable for dry, sensitive, inflamed and lusterless skin, and is a natural moistening agent. Is rich in minerals, proteins and various vitamins, is a vegetable oil with excellent skin caring and moistening effects, and is suitable for various skin types. It can effectively relieve the itching of skin and eliminate red swelling, dryness and inflammation. Can stimulate pituitary gland, thymus gland and adrenal gland of endocrine system, and promote cell renewal.
Coconut oil is the endosperm of coconut, a natural vegetable oil extracted after baking and steaming, and a natural fatty acid. Coconut oil is known as "edible cosmetics" and "beauty oil", and is light in weight, clear and pure. Coconut oil contains a large amount of saturated fatty acid esters, free fatty acids, phytosterols, proteins, vitamin B1, vitamin C, and the like. Has multiple functions of moistening and moisturizing, softening skin, preventing aging and the like. Coconut oil is very similar to skin surface lipid components, so that the coconut oil can be quickly absorbed by skin, the moisture loss of the epidermis is reduced to the maximum extent, and the moisturizing effect is achieved. Coconut oil can smooth and moisten dry textures, increase skin surface lipid, and deeply moisten skin. Not only is beneficial to strengthening the basal tissues and cells of the skin, but also can remove dead skin and revive the skin.
The safflower seed oil contains a large amount of vitamin E, phytosterol, flavone and oryzanol, and the vitamin E has the effects of resisting oxidation, eliminating free radicals, delaying skin aging, avoiding pigment deposition on the surface layer of the skin and fading color spots; the oryzanol can promote skin microcirculation function to protect skin, and make skin delicate and elastic, and has effects of caring skin.
The rose essential oil is called "essential oil queen". The rose essential oil has three special effects of super-strong permeability, perfect absorptivity and 100% safety. The rose essential oil can penetrate into skin and human body and circulate without chemical residual natural essential oil of maintenance elements, and has good permeability and good fusion. By directly exciting various metabolic reactions of skin cells, cell regeneration energy is activated, oxygen free radical activity is inhibited, blood flow is enhanced, and oxidation of tyraminidase is controlled; decomposing pigment, accelerating the balance of nutrients and water, and enhancing the discharge of cytotoxin, thereby achieving the overall regulation and control of the internal and external environments of the skin; the rose essential oil is suitable for skin care, has the effects of resisting aging, preventing wrinkles and preserving moisture, and has good curative effect on various skins. Essential oil, known as "liquid gold", is popular with many consumers in the field of cosmetic products due to its unique natural characteristics and efficacy. The plant essential oil has the advantages of extremely small molecular structure, rapid skin permeation and high absorption rate. Therefore, the development of lip care products using plant extracts may give consumers a new direction.
The nano emulsion, also called microemulsion, is a thermodynamically stable, isotropic, transparent or semitransparent homogeneous dispersion system nano emulsion with the particle size of 1-100 nm, which is spontaneously formed by water, oil, surfactant, cosurfactant and the like, and has the advantages of small droplet particle size, faster percutaneous permeation absorption effect and controllable release potential function in the transfer process. The solubilization of the functional components of the plant essential oil is promoted, and the stability of the biological characteristics of the functional components is maintained. Meanwhile, the particle size of the nano emulsion is very small, so that the problems of layering, sedimentation and flocculation caused by gravity and Brownian motion in the storage process can be solved, and the nano emulsion has better long-term stability.
The purpose of the invention is realized by the following technical scheme:
a plant essential oil nanoemulsion comprises emulsifier, water phase and oil phase; taking magnolia extract and deionized water as water phases; the oil phase comprises the following components in percentage by mass: 40.0 to 70.0 percent of cocoa butter, 10.0 to 25.0 percent of avocado oil, 5.0 to 15.0 percent of sweet almond oil, 5.0 to 10.0 percent of coconut oil, 5.0 to 10.0 percent of safflower seed oil and 3.0 to 6.0 percent of rose essential oil;
the volume ratio of the oil phase to the water phase to the emulsifier is 8:2: 1-20: 2: 1; the emulsifier is formed by mixing Span80 and Tween 20; the mass ratio of the magnolia extract to the deionized water is 1: 10-1: 20.
To further achieve the object of the present invention, preferably, the magnolia extract is prepared according to the following method: grinding fresh magnolia, extracting with an ethanol solution at 40-60 ℃ to obtain an magnolia extracting solution, removing ethanol, and carrying out vacuum freeze drying on the remaining aqueous solution to obtain the magnolia extract.
Preferably, the volume concentration of the ethanol solution is 50-80%.
Preferably, the leaching time is 1-2 hours; the volume ratio of the extracted fresh magnolia flower to the ethanol solution is 1: 5-1: 15.
Preferably, the ethanol removal is realized by rotary evaporation of the extracting solution at 40-50 ℃.
Preferably, the mass ratio of the Span80 to the Tween20 is 9: 1-19: 1.
The preparation method of the plant essential oil nanoemulsion comprises the following steps:
1) mixing Span80 with Tween20 to prepare a mixed emulsifier;
2) by mass percentage, 40.0-70.0 percent of cocoa butter, 10.0-25.0 percent of avocado oil, 5.0-15.0 percent of sweet almond oil, 5.0-10.0 percent of coconut oil, 5.0-10.0 percent of safflower seed oil and 3.0-6.0 percent of rose essential oil are uniformly mixed to be used as an oil phase;
3) taking the magnolia flower extract and deionized water as water phases, and controlling the mass ratio of the magnolia flower extract to the deionized water to be 1: 10-1: 20;
4) dispersing an emulsifier in the uniformly mixed oil phase at room temperature, and adding the water phase into the oil phase added with the emulsifier; obtaining an oil phase-water phase-emulsifier mixture;
5) stirring the obtained oil phase-water phase-emulsifier mixture at the stirring speed of 400-800 rpm for 10-30 minutes to prepare a coarse emulsion;
6) heating the crude emulsion to 75-85 ℃, keeping the temperature constant for 5-8 minutes, then placing the emulsion at room temperature for natural cooling to obtain the plant essential oil nano emulsion, and determining the particle size diameter of the prepared plant essential oil nano emulsion to be 20-40 nm by using a laser particle size distribution instrument.
The application of the plant essential oil nanoemulsion in lip care products comprises the following steps: the lip care product is lip glaze, lipstick, lip gloss, lip oil or lipstick.
Preferably, the lip glaze is prepared by the following method: by mass percentage, 55.9 to 88.6 percent of plant essential oil nano emulsion, 1.0 to 4.0 percent of squalane, 0.1 to 0.4 percent of vitamin E and 10.0 to 40.0 percent of polyisobutene are uniformly mixed.
Preferably, the lipstick is prepared by the following method: by mass percentage, 52.9 to 80.6 percent of plant essential oil nano emulsion, 1.0 to 4.0 percent of squalane, 0.1 to 0.4 percent of vitamin E, 10.0 to 40.0 percent of polyisobutylene and 3.0 to 8.0 percent of beeswax are evenly mixed.
Compared with the prior art, the invention has the following beneficial effects:
1) the magnolia flower extract is used as the water phase, the uniformly mixed plant essential oil is used as the oil phase to prepare the water-in-oil plant essential oil nano emulsion, the transdermal absorption speed of the plant essential oil treated by the method is increased, the magnolia flower extract added in the water phase can promote the plant essential oil to permeate the skin, when a lip product prepared from the plant nano essential oil is applied to lips, the retention time of oily substances on the surface of the skin is reduced, the absorption speed of the product is high, and the product is fresh and not greasy after being used.
2) The squalane and magnolia flower extract added when the plant essential oil nanoemulsion is used for preparing the lip product have a synergistic effect on the aspect of promoting the plant essential oil to permeate into the skin, the prepared lip product is high in absorption speed, and the lip product is fresh and non-greasy after being applied.
3) The plant essential oil is selected as a main raw material, heavy metal, alcohol, hormone, mineral oil, pigment and other chemical components are not contained, most of the raw materials are food-grade, the formula is soft, the plant essential oil has no stimulation to skin, and the plant essential oil is green and safe and can meet the requirement of consumers on pursuing health.
Drawings
Fig. 1 is a graph showing the water loss from the skin after use of lip glaze, which is a lip product obtained in examples and comparative examples of the present invention.
Figure 2 is a graph showing the loss of moisture from the skin after application of the lip product, lipstick, obtained in the examples of the present invention and comparative example.
Detailed Description
In order to make the objects, technical solutions and advantageous technical effects of the present invention clearer, the present invention is further described below with reference to examples 1 to 3 and comparative examples 1 to 6. It should be understood that the embodiments described in this specification are only for the purpose of explaining the present invention and do not limit the scope of the present invention.
In the following examples, all the raw materials were purchased from commercial sources unless otherwise specified.
Example 1
A plant essential oil nanoemulsion comprises emulsifier, water phase and oil phase; taking magnolia extract and deionized water as water phases; the oil phase comprises the following components in percentage by mass: 40.0% of cocoa butter, 20.0% of avocado oil, 15.0% of sweet almond oil, 10.0% of coconut oil, 10.0% of safflower seed oil and 5.0% of rose essential oil.
A preparation method of plant essential oil nanoemulsion comprises the following steps:
1) mixing Span80 with Tween20 to prepare an emulsifier, wherein the mass ratio of Span60 to Tween60 is 9: 1;
2) the method comprises the following steps of: 40.0% of cocoa butter, 20.0% of avocado oil, 15.0% of sweet almond oil, 10.0% of coconut oil, 10.0% of safflower seed oil and 5.0% of rose essential oil are uniformly mixed to be used as an oil phase;
3) the magnolia flower extract and deionized water are used as water phases, and the mass ratio of the magnolia flower extract to the deionized water is 1: 10; the magnolia extract is prepared according to the following method: selecting fresh magnolia flower, grinding, leaching for 1 hour at 60 ℃ by using 50% volume fraction ethanol according to the feed liquid mass ratio of 1:5 to obtain magnolia flower extract, rotatably evaporating the extract at 40 ℃ to remove ethanol, and carrying out vacuum freeze drying on the residual aqueous solution to obtain the magnolia flower extract.
4) Dispersing an emulsifier in the uniformly mixed oil phase at room temperature, and adding the water phase into the oil phase added with the emulsifier; obtaining an oil phase-water phase-emulsifier mixture, wherein the volume ratio of the oil phase to the water phase to the emulsifier is 8:2: 1;
5) stirring the obtained oil phase-water phase-emulsifier mixture at a fixed stirring speed of 400rpm for 30 minutes to prepare a coarse emulsion;
6) heating the crude emulsion to 75 ℃, keeping the temperature for 8 minutes, and naturally cooling at room temperature; obtaining plant essential oil nano emulsion; the particle size of the prepared plant essential oil nanoemulsion is measured by using a laser particle size distribution instrument, and the diameter of the prepared plant essential oil nanoemulsion is 20-40 nm.
Preparing the prepared plant essential oil nano emulsion into lip glaze, wherein the lip glaze comprises the following raw materials in percentage by mass: 55.9% of plant essential oil nano emulsion, 4.0% of squalane, 0.1% of vitamin E and 40% of polyisobutene. Stirring the components uniformly, discharging the materials into a material storage container, aging for not less than 48 hours, and filling after the materials are inspected to be qualified.
The lipstick is prepared from the prepared plant essential oil nano emulsion, and comprises the following raw materials in percentage by mass: 52.9% of plant essential oil composition, 4.0% of squalane, 0.1% of vitamin E, 40.0% of polyisobutene and 3.0% of beeswax. Stirring the components uniformly, discharging the materials into a material storage container, aging for not less than 48 hours, and filling after the materials are inspected to be qualified.
Example 2
A plant essential oil nanoemulsion comprises emulsifier, water phase and oil phase; taking magnolia extract and deionized water as water phases; the oil phase comprises the following components in percentage by mass: 70.0% of cacao butter, 10.0% of avocado oil, 7% of sweet almond oil, 5.0% of coconut oil, 5.0% of safflower seed oil and 3.0% of rose essential oil.
Mixing Span80 with Tween20 to prepare a mixed emulsifier, wherein the mass ratio of Span60 to Tween60 is 19: 1; uniformly mixing plant essential oil as an oil phase, and magnolia extract-deionized water as a water phase (mass ratio is 1: 20); dispersing a proper amount of emulsifier into the uniformly mixed plant essential oil at room temperature, and adding a water phase into the plant essential oil solution of the emulsifier to obtain an oil phase-water phase-emulsifier mixture, wherein the volume ratio of the oil phase to the water phase to the emulsifier is 20:2: 1; stirring the oil phase-water phase-emulsifier mixture at a fixed stirring speed of 800rpm for 10 minutes to prepare a coarse emulsion; heating the crude emulsion to 85 ℃, keeping the temperature for 5 minutes, and then naturally cooling the emulsion at room temperature; the particle size of the prepared plant essential oil nanoemulsion is measured by using a laser particle size distribution instrument, and the diameter of the prepared plant essential oil nanoemulsion is 20-40 nm.
The magnolia extract is prepared by the following steps: selecting a proper amount of fresh magnolia, grinding, extracting for 2 hours at 40 ℃ by using ethanol with volume fraction of 80% according to the material-liquid ratio (mass ratio) of 1:15 to obtain magnolia extract, rotatably evaporating the extract at 50 ℃ to remove ethanol, and carrying out vacuum freeze drying on the residual water solution to obtain the magnolia extract.
The lip glaze is prepared from the prepared plant essential oil nanoemulsion, wherein the proportion of each component is 88.6% of the plant essential oil nanoemulsion, 1.0% of squalane, 0.4% of vitamin E and 10.0% of polyisobutene. Stirring the components uniformly, discharging the materials into a material storage container, aging for not less than 48 hours, and filling after the materials are inspected to be qualified.
The prepared plant essential oil nano-emulsion is prepared into lipstick, wherein the ratio of each component is 80.6% of plant essential oil composition, 1.0% of squalane, 0.4% of vitamin E, 10.0% of polyisobutene and 8.0% of beeswax. Stirring the components uniformly, discharging the materials into a material storage container, aging for not less than 48 hours, and filling after the materials are inspected to be qualified.
Example 3
A plant essential oil nanoemulsion comprises emulsifier, water phase and oil phase; taking magnolia extract and deionized water as water phases; the oil phase comprises the following components in percentage by mass: 50.0% of cocoa butter, 25.0% of avocado oil, 5.0% of sweet almond oil, 8.0% of coconut oil, 6.0% of safflower seed oil and 6.0% of rose essential oil.
Mixing Span80 with Tween20 to prepare a mixed emulsifier, wherein the mass ratio of Span60 to Tween60 is 15: 1; uniformly mixing plant essential oil serving as an oil phase, and magnolia flower skin extract and deionized water serving as a water phase (the mass ratio is 1: 15); dispersing a proper amount of emulsifier into the uniformly mixed plant essential oil at room temperature, and adding a water phase into the plant essential oil solution of the emulsifier to obtain an oil phase-water phase-emulsifier mixture, wherein the volume ratio of the oil phase to the water phase to the emulsifier is 16:2: 1; stirring the oil phase-water phase-emulsifier mixture at a fixed stirring speed of 600rpm for 20 minutes to prepare a coarse emulsion; heating the crude emulsion to 80 ℃, keeping the temperature for 6 minutes, and then naturally cooling the emulsion at room temperature; the particle size of the prepared plant essential oil nanoemulsion is measured by using a laser particle size distribution instrument, and the diameter of the prepared plant essential oil nanoemulsion is 20-40 nm.
The magnolia extract is prepared by the following steps: selecting a proper amount of fresh magnolia, grinding, leaching for 1.5 hours at 50 ℃ by using ethanol with volume fraction of 65% according to the material-liquid ratio (volume ratio) of 1:10 to obtain magnolia extract, rotatably evaporating the extract at 45 ℃ to remove the ethanol, and carrying out vacuum freeze drying on the residual water solution to obtain the magnolia extract.
The lip glaze is prepared from the prepared plant essential oil nanoemulsion, wherein the proportion of each component is 70% of the plant essential oil nanoemulsion, 3.0% of squalane, 0.2% of vitamin E and 26.8% of polyisobutene. Stirring the components uniformly, discharging the materials into a material storage container, aging for not less than 48 hours, and filling after the materials are inspected to be qualified.
The prepared plant essential oil nano emulsion is prepared into lipstick, wherein the ratio of each component is 67.8% of plant essential oil composition, 3.0% of squalane, 0.2% of vitamin E, 25.0% of polyisobutene and 4.0% of beeswax. Stirring the components uniformly, discharging the materials into a material storage container, aging for not less than 48 hours, and filling after the materials are inspected to be qualified.
Comparative example 1
The vegetable essential oil composition consists of the following components (by mass percent): 57.0% of cocoa butter, 18.0% of avocado oil, 8.0% of sweet almond oil, 7.0% of coconut oil, 6.0% of safflower seed oil and 4.0% of rose essential oil.
The lip glaze is prepared from the plant essential oil composition, wherein the content of each component comprises, by mass, 70% of the plant essential oil composition, 0.2% of vitamin E and 29.8% of polyisobutene.
The plant essential oil composition is prepared into lipstick, wherein the content of each component in percentage by mass is 70 percent of the plant essential oil composition, 0.3 percent of vitamin E, 21.7 percent of polyisobutylene and 8.0 percent of beeswax
Comparative example 2
The plant essential oil composition of comparative example 1 was used as an oil phase and deionized water was used as an aqueous phase to prepare a water-in-oil plant essential oil nanoemulsion by the following method: the plant essential oil composition comprises 57.0% of cacao butter, 18.0% of avocado oil, 8.0% of sweet almond oil, 7.0% of coconut oil, 6.0% of safflower seed oil and 4.0% of rose essential oil by mass. Mixing Span80 and Tween20 according to the mass ratio of 15:1 to prepare a mixed emulsifier; taking the uniformly mixed plant essential oil as an oil phase and deionized water as a water phase; dispersing a proper amount of emulsifier in an oil phase at room temperature, and adding an aqueous phase into the oil phase containing the emulsifier to obtain an oil phase-aqueous phase-emulsifier mixture, wherein the volume ratio of the oil phase to the aqueous phase to the emulsifier is 16:2: 1; stirring the oil phase-water phase-emulsifier mixture at a fixed stirring speed of 600rpm for 20 minutes to prepare a coarse emulsion; and heating the crude emulsion to 80 ℃, keeping the temperature for 6 minutes, then naturally cooling the emulsion at room temperature, and measuring the particle size of the prepared plant essential oil nanoemulsion by using a laser particle size distribution instrument, wherein the diameter of the nanoemulsion is 20-40 nm.
The lip glaze is prepared from the plant essential oil nanoemulsion, wherein the content of each component comprises 65 mass percent of the plant essential oil nanoemulsion, 0.2 mass percent of vitamin E and 34.8 mass percent of polyisobutene.
The lipstick is prepared from the plant essential oil nanoemulsion, wherein the contents of the components in percentage by mass are 65% of the plant essential oil nanoemulsion, 0.3% of vitamin E, 26.7% of polyisobutene and 8.0% of beeswax.
Comparative example 3
Preparing the plant essential oil nanoemulsion of the comparative example 2 into lip glaze, wherein the contents of the components in percentage by mass are 65% of the plant essential oil nanoemulsion, 0.2% of vitamin E, 1% of squalane and 34.8% of polyisobutylene.
The plant essential oil nanoemulsion of the comparative example 2 is prepared into the lipstick, wherein the contents of the components in percentage by mass are 65% of the plant essential oil nanoemulsion, 0.3% of vitamin E, 1% of squalane, 25.7% of polyisobutene and 8.0% of beeswax.
Comparative example 4
Lipstick prepared according to the invention patent application CN 201910467104.6.
Comparative example 5
Lipstick prepared according to the invention patent application CN 201810401018.0.
Comparative example 6
The lip oil is rich in natural plant extraction components such as jojoba oil and hazelnut oil, can reduce lip lines and improve the phenomenon of dry and peeling of lips, tastes good, has high moistening degree, and has the main effects of repairing, moistening and moisturizing. The product has high safety, and can be used in lactation period.
Application example 1: sensory evaluation
The lip products of examples 1 to 3 and comparative examples 1 to 6 were evaluated and scored for texture, color, aroma, and after application, extensibility, moisture (oil-wet feeling), thickness, absorbency, irritation, and sensitivity, with the scoring criteria shown in table 1.
The test population is 400 tested persons with the age range of 20-55 years. All subjects had no history of any skin and systemic disease, and there were no abnormalities in the skin at the sites tested.
The test method comprises the following steps: the test persons applied the respective samples to the lips, and scored according to the scoring standards, and the total scores of the evaluators were summed up to calculate the average value.
And (3) testing results: the lip gloss and lipstick of the examples and comparative examples were subjected to sensory evaluation, and the test results are shown in Table 2. As can be seen from Table 2, the lip glaze and lipstick prepared by the invention have significantly higher comprehensive scores than the lip glaze and lipstick prepared by the comparative example.
TABLE 1 sensory Scoring criteria
Index (I) Definition of Score range
Texture of Like degree of product texture 0 (dislike) → 10 (like)
Color and luster Like degree of color and luster of product 0 (dislike) → 10 (like)
Fragrance Like degree of fragrance of product after smearing 0 (dislike) → 10 (like)
Ductility of the alloy Ease of moving the product over the skin after a specified number of applications 0 (difficult) → 10 (easy)
Moistening degree Evaluation of degree of oil-extended degree of product to skin 0 (small) → 10 (large)
Feeling of heaviness The amount of the sample between the finger tip and the skin is sensed, and the air permeability of the product is indirectly reflected 0 (Large) → 10 (Small)
Absorbency of Indirectly judging the difficulty of absorption through the number of smearing circles for complete absorption of the product 0 (difficult) → 10 (easy)
Irritation property Whether the product has discomfort around the eyes after being smeared 0 (none) → 20 (stimulus)
Hypersensitivity to skin The face has red and swelling allergy after being applied 0 (none) → 20 (allergy)
Comparative example 1 is a lip product prepared by compounding plant essential oil, untreated plant essential oil has certain irritation to skin in the use process, the greasiness of the essential oil is relatively large, and the problem of no refreshing after smearing occurs, and sensory evaluation results show that: the lip products of the examples had significantly higher sensory scores in texture, color and after-application extensibility, body, absorbency, irritation, sensitivity, etc. than the lip product of comparative example 1. The lip product prepared by the method has good skin feel after use, is fresh and cool, is not greasy, is not allergic after being smeared and has small stimulation to the skin.
Comparative example 2 is a lip product prepared from a plant essential oil nanoemulsion without adding a magnolia flower extract into a water phase, and comparative example 3 is prepared by adding squalane into the lip product of comparative example 2, sensory evaluation results show that the extensibility, the heaviness and the absorbability of the lip product of comparative example 2 and comparative example 3 after the product is used are slightly better than those of comparative example 1, the lip product of the example has scores of the texture, the extensibility, the heaviness and the absorbability after the product is applied which are obviously better than those of comparative example 2 and comparative example 3, which shows that the effect of the lip product is relatively small although the lip product can be improved by preparing the plant essential oil into the nanoemulsion or matching the plant essential oil nanoemulsion with squalane, and the sensory evaluation of the lip product prepared by adding the magnolia flower extract into the water phase of the invention is obviously better than that of comparative examples 2-3, mainly because the added magnolia flower extract can promote the transdermal absorption of the plant essential oil, the retention time of the plant essential oil on the surface layer of the skin is reduced, the greasy feeling after the product is used is reduced along with the extension of the smearing time, and the ductility, the heavy feeling and the absorbability after the product is smeared are obviously improved.
Compared with comparative example 4, comparative example 4 provides a purely natural moisturizing lipstick, wherein the moisturizing and moisturizing components, the flavoring components, the antioxidant components, the antiseptic components and the bacteriostatic components are all from natural plants. Sensory evaluation results show that the comprehensive score of the lipstick of the comparative example 4 is obviously lower than that of the lipstick of the example, the main reason is that the content of the oily components in the lipstick of the comparative example 4 is higher, the oily components are not treated during preparation of the lipstick, and the prepared lipstick is heavy in greasy feeling after being smeared, difficult to push away and slow in absorption.
Examples comparative example 5 discloses a refreshing lipstick, which comprises plant powders (willow leaf powder, watermelon peel powder, okra powder), oily components (olive oil, shark liver oil, lanolin, beeswax) and water-soluble components (aloe gel juice, glycerin, gastrodin), and sensory results show that the score of comparative example 5 is the lowest, and is only 27.1 points, and skin feel unacceptable to general consumers is mainly due to the fact that the very large component of the plant powder in the technology is cellulose and can not be uniformly dissolved in oil or water, so that the color, texture, fragrance and use feel after application need to be improved.
The comparative example 6 is a commercially available lip oil, the lip oil is mainly moisturized and moistened, the main component of the lip oil is natural plant essential oil, sensory results show that the score of the example is remarkably higher than that of the comparative example 6, the lip product of the example is fresh and non-greasy after being coated, and on the contrary, the commercially available lip oil of the comparative example 6 is fragrant and irritant, the lip oil is difficult to push away after being coated, the lip oil absorption effect is poor, the greasy feeling is heavy, and the lip oil has an allergy phenomenon after being used.
TABLE 2 sensory test results for the products
Figure BDA0002587679890000101
Application example 2: tackiness test
To further illustrate the beneficial effects of the present invention, the degree of stickiness of the lip products of examples 1-3 and comparative examples 1-6 was determined.
Testing the population: 300 subjects in the age range of 20-45 years. All subjects had no history of any cutaneous and systemic disorders, and no abnormalities were found in the skin at the sites tested. 20 persons per product were tested.
The test method comprises the following steps: the testee needs uniform mild detergent cleaning before the test, the product is smeared on the area with the diameter of about 2cm selected from the back of the hand, immediately after smearing, 5 minutes, 10 minutes, 30 minutes, 60 minutes and 90 minutes, 20 particles of paper (with the diameter of 2mm) are scattered on the back of the hand and stay for 2-3 seconds, then the back of the hand is tilted immediately, the number of the paper left on the back of the hand is recorded and repeated for 3 times respectively, the average value of the paper is obtained, and the stickiness of the product is judged according to the number of the paper.
And (3) testing results: the results of the tackiness test are shown in Table 3. The results of the stickiness test show that the lip products of the examples have significantly lower amounts of paper left on the back of the hand as the application time is extended than the comparative examples, indicating that the lip products of the examples have significantly lower stickiness after use than the comparative examples.
In comparison with the examples, comparative example 1 is a lip product prepared directly from plant essential oil without any treatment, and the plant essential oil is relatively greasy by itself, so that the prepared product is greasy and heavy after being applied to the lips, and 90 minutes after application, the number of the paper sheets remained on the back of the hand is 9.6 lip gloss and 10.2 lipstick, which are significantly higher than those of examples 1-3.
Comparative example 2 is a lip product prepared from plant essential oil nanoemulsion without adding magnolia flower extract in water phase, and comparative example 3 is a lip product prepared from comparative example 2 and added with squalane, compared with comparative example 1, after the lip product is applied in comparative examples 2 and 3, the number of paper sheets remained on the back of hands is slightly reduced along with the extension of the application time, which shows that the stickiness of the lip product can be reduced by preparing plant essential oil into nanoemulsion or combining plant essential oil nanoemulsion with squalane, and compared with the example, the lip product prepared in comparative examples 1 and 2 is still higher in stickiness. The vegetable essential oil is prepared into the nano emulsion or the squalane is added to reduce the viscosity of the product.
Comparative example 4 is a pure natural moisturizing lipstick, the product is mainly prepared from various plant essential oils, plant extracts and beeswax, and the result of a stickiness test shows that the number of paper sheets remaining on the back of the hand reaches 9.6 after 90 minutes of smearing along with the time after smearing the product, and the product is not fresh and has high stickiness after smearing; the number of the paper sheets remained on the back of the hand at 90 minutes after the product of the embodiment is smeared is only 1.2-1.7, the stickiness is obviously reduced, and the product is obviously superior to that of the comparative example 4.
Comparative example 5 is a refreshing lipstick mainly prepared from plant powder, oily components, water-soluble components and beeswax as main raw materials, the product is refreshing, and the result of the stickiness test shows that the product has a high number of paper sheets left on the back of the hand after being applied, and 12.2 paper sheets still remain after 90 minutes, so that the refreshing degree of the lip product of the invention is remarkably superior to that of comparative example 5.
The lip balm is prepared from natural plant extract components, is rich in natural plant extract components such as jojoba seed oil and hazelnut oil, and has the effects of repairing, moistening and moisturizing. The residual quantity of the instant hand back paper piece after being smeared by the product is 20 which is higher than 15.5-17.0 of the product of the invention, the residual quantity is still 14.0 after being smeared for 90 minutes, the product of the comparative example 6 is slow to absorb, the viscosity after being smeared is high, and the refreshing degree after being smeared by the product of the invention is obviously better than that of the comparative example 6.
Compared with the examples, the components and the compositions of the comparative examples 4 to 6 are different from those of the invention, and the results of the viscosity degree test show that the products of the comparative examples 4 to 6 are also higher in viscosity degree, and as can be seen from the table 3, the invention has obvious advantages in viscosity degree compared with the prior art.
TABLE 3 lip product tackiness test results
Figure BDA0002587679890000121
Application example 3: lip product moisture retention test-loss of moisture through The Epidermis (TEWL)
In order to explain that the lip products prepared according to the present invention have high moisture retention performance on the premise of high penetration rate, skin moisture loss (TEWL) tests were performed after using the lip products of examples 1 to 3 and comparative examples 1 to 6, and the moisture retention performance of the products was evaluated. The TEWL value is an important indicator of the quality of the skin barrier, and a lower TEWL value indicates a better barrier function of the skin, whereas a worse TEWL value indicates a poorer barrier function of the skin. The trans-epidermal water loss (TEWL) was measured using a Tewameter TM300 instrument, the principle of measurement being Fick's law of diffusion. The amount of water vapor emitted through the epidermis was directly measured by measuring the pressure gradient of water vapor near the epidermis (within about 1 cm) formed at two different points by the water loss from the horny layer.
The test population: the trial population: 300 subjects in the age range of 20-45 years. All subjects had no history of any cutaneous and systemic disorders, and no abnormalities were found in the skin at the sites tested. 20 persons per product were tested.
The test method comprises the following steps: before test, the testee needs uniform mild detergent to clean the flexed side of the forearm in a constant environment (indoor temperature is 22-24 ℃, humidity is 50%60%) for 30min, then applying the product to the test site, gently patting until absorption, 5 × 5cm per test area2The test sample was 0.2g, and the transepidermal water loss was measured before application (0 hour) and 1 hour, 2 hours, 4 hours after application, in the test area and the blank control area, respectively.
And (3) testing results: in order to clearly show the comparative data of the lip product, the water dispersion loss of the skin after the lip glaze and the lipstick product are respectively shown in the following figures, in particular to figure 1 and figure 2. As can be seen from the figure, the skin moisture content loss of examples 1-3 and comparative examples 1-3 after application with the lip product is significantly lower than that of comparative examples 4-6, indicating that the lip products of examples and comparative examples 1-3 have better moisture retention than comparative examples 4-6.
Comparative example 4 is a natural moisturizing lipstick, the natural plant oil components of which include shea butter, jojoba oil, grape seed oil, sweet almond oil, olive oil and plant essential oil, the difference of the product from the invention is that part of the essential oil components are different from the invention, after the lipstick prepared by comparative example 4 is used, the water dispersion of lips is slightly reduced, 14.67% before smearing and 12.65% after 4 hours, and the product has a general moisturizing effect; comparative example 5 is a refreshing lipstick, which is completely different from the present invention in the composition in that the oily components are mainly olive oil, shark liver oil, etc., and which shows no improvement in water dispersion loss of lips after use, 14.17% before application and 14.28% after 4 hours, and which is poor in moisturizing effect; the product of the comparative example 6 is prepared by using natural plant extract components, is rich in natural plant extract components such as jojoba seed oil and hazelnut oil, and is mainly used for moisturizing, but the water dispersion loss of the skin after the product is used is slightly reduced, namely 14.59% before the product is applied and 12.08% after 4 hours, but the reduction is not obvious, and the lip moisturizing effect is not obvious.
Examples 1-3 and comparative examples 1-3 used lip products prepared with the plant essential oil composition of the present invention, the essential oils including cocoa butter, avocado oil, sweet almond oil, coconut oil, safflower seed oil, rose essential oil, the amount of skin moisture loss was significantly reduced after using examples 1-3 and comparative examples 1-3, for example, the skin moisture content of example 1 was 14.98% before application, was reduced to 10.05% 4 hours after application, the skin moisture content of comparative example 1 was 15.02% before application, and was reduced to 10.38% 4 hours after application, indicating that the lip products prepared with the essential oil composition of the present invention had good moisture retention properties.
The result shows that the plant essential oil composition has good moisturizing effect only by selecting the plant essential oil composition and meeting the proportion relation of the components.
Application example 3: transdermal absorption test of essential oil
In order to illustrate the characteristics of quick absorption, refreshing and non-greasy after the lip product prepared by the invention is applied, the functional components such as plant essential oil and the like in the lip product are subjected to a transdermal absorption test, and the mechanism of quick absorption is discussed.
Test group a: the plant essential oil composition of comparative example 1 was selected.
Test group B: the plant essential oil nanoemulsion of comparative example 2 was selected.
Test group C: and (3) uniformly mixing the plant essential oil nanoemulsion of the test group B and squalane to obtain a sample of the test group D, wherein the mass ratio of the plant essential oil nanoemulsion to the squalane is 60: 1.
Test group D: the plant essential oil nanoemulsion of example 1 was selected.
Test group E: and (3) uniformly mixing the plant essential oil nanoemulsion of the test group D and squalane to obtain a test group sample, wherein the mass ratio of the plant essential oil nanoemulsion to the squalane is 60: 1.
The test method comprises the following steps:
(1) in vitro skin preparation
Normally feeding SD rat for 1 day, anaesthetizing, taking blood from neck to death, removing skin of lower abdomen, removing subcutaneous fat and mucous membrane, cleaning with normal saline until the lotion is white and turbid, soaking in proper amount of normal saline, sucking water on skin surface with filter paper, selecting skin with proper size and without damage, spreading on aluminum foil, packaging, storing in refrigerator (-20 deg.C), and naturally thawing physiological saline before experiment.
(2) Transdermal test procedure
Fixing prepared skin on Franz diffusion cellThe skin is close to the skin with stratum corneum facing upwards, the receiving pool has a volume of 6.5ml and an effective permeation area of 3.14cm2The dermis side of the skin is contacted with a receiving pool, air bubbles are discharged, the receiving liquid is 50% ethanol-normal saline, the water bath circulation outside a Franz diffusion pool is (37 +/-0.5) DEG C, and 200rmp is stirred in the receiving pool at a constant speed.
After the temperature of the system is constant in the rat transdermal experiment, 1.0ml of sample liquid is respectively and lightly added into the drug supply pool. Stirring at constant speed and timing. 1.0ml of receiving liquid is extracted from the sampling tube at 2h, 4h and 8h respectively, equal volume of isothermal 50% ethanol-physiological saline is timely supplemented after each sampling, and bubbles in the receiving pool are removed. Collecting a sample of the receiving pool. And (3) placing the collected receiving liquid sample in a glass test tube with a plug, storing the sample at low temperature in a sealed and dark manner, and completing the measurement within 24 h. The sample solution is filtered by a microporous filter membrane with the aperture of 0.45 mu m and then subjected to gas chromatography-mass spectrometry analysis. The concentration of the essential oil was calculated from the working curve, and the cumulative permeation per unit area (Qn) was calculated as shown in the following formula
Figure BDA0002587679890000141
In the formula CnThe concentration of the plant essential oil measured for the nth sampling point is measured in the unit of mu g/ml, wherein n is 1, 2, 3, CnThe concentration of the plant essential oil in the receiving pool is measured in 2h, 4h and 8 h; v is the volume of the receiving solution, and 6.5ml is taken in the test of the invention; ci is the plant essential oil concentration measured at the ith sampling point, wherein the unit is mu g/ml, and the plant essential oil concentration is specifically the essential oil concentration measured by extracting 1ml of receiving solution; vi is the sampling volume of the ith sampling point, and 1.0ml is taken in the invention; a is the penetration area, which is 3.14cm in the test of the invention2
(3) Transdermal absorption test
The solution preparation precisely weighs 1.00g of samples of groups A to E in the test, the samples are placed in a 100mL brown volumetric flask, 50% ethanol-physiological saline is added to dilute the samples to the scale, the samples are shaken up to prepare sample solution with the concentration of 10.0mg/mL as transdermal sample solution, and three groups of parallel tests are carried out on each concentration gradient.
And (3) test results: the results of the percutaneous absorption test are shown in Table 4. The test result shows that: the essential oil in the five test samples has higher skin permeability, and the permeability of the essential oil is E & gt D & gt C & gt B & gt A from high to low.
Compared with the test group A, the test group B prepares the essential oil of the test group A into the nano emulsion, which shows that the transmittance of the plant essential oil can be effectively increased by preparing the plant essential oil composition into the nano emulsion by the technology of the invention; the experiment group C is that squalane is added on the basis of the experiment group B, the experiment group D is plant essential oil nano emulsion prepared by adding magnolia flower extract to the water phase of the experiment group B, the essential oil transmittance of the experiment group D is higher than that of the experiment group C, the essential oil transmittance of the plant essential oil unit area of the experiment group C and the experiment group D is respectively higher than that of the experiment group B, the added magnolia flower extract and squalane can promote the transdermal absorption speed of the plant essential oil, and the function of the magnolia flower extract in promoting the transdermal absorption of the essential oil is stronger than that of the squalane. The experiment E group is plant essential oil nano emulsion prepared by adding magnolia flower extract into water phase and is simultaneously added with squalane, and after 8-hour transdermal absorption experiment, the amount of essential oil penetrating per unit area is 98.01 +/-0.220 mu g, which is obviously higher than that of 60.83 +/-0.196 mu g of the group C and that of 67.15 +/-0.312 mu g of the group D, which shows that the magnolia flower extract and squalane play a synergistic role in promoting the transdermal absorption of the plant essential oil. The reason why the lipstick prepared by the invention is fast in absorption, fresh and non-greasy after being applied can be illustrated, and the magnolia flower extract and squalane synergistically promote the plant essential oil to permeate the skin, the speed of oily components permeating the skin is higher than that of a comparative example, the retention time of the plant essential oil on the surface layer of the skin is reduced, and the greasy feeling after the product is used is reduced along with the prolonging of the application time.
TABLE 4 cumulative penetration per unit area of essential oil in different samples
Group of A B C D E
2h 16.072±0.116 21.31±0.021 25.86±0.247 31.02±0.014 42.34±0.159
4h 30.082±0.254 35.09±0.102 46.07±0.265 55.07±0.217 73.02±0.305
8h 43.307±0.298 50.07±0.210 60.83±0.196 67.15±0.312 98.01±0.220
Appropriate changes and modifications to the embodiments described above will become apparent to those skilled in the art from the disclosure and teachings of the foregoing description. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some modifications and variations of the present invention should fall within the scope of the claims of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

Claims (10)

1. A plant essential oil nanoemulsion comprises emulsifier, water phase and oil phase; the method is characterized in that: taking magnolia extract and deionized water as water phases; the oil phase comprises the following components in percentage by mass: 40.0 to 70.0 percent of cocoa butter, 10.0 to 25.0 percent of avocado oil, 5.0 to 15.0 percent of sweet almond oil, 5.0 to 10.0 percent of coconut oil, 5.0 to 10.0 percent of safflower seed oil and 3.0 to 6.0 percent of rose essential oil;
the volume ratio of the oil phase to the water phase to the emulsifier is 8:2: 1-20: 2: 1; the emulsifier is formed by mixing Span80 and Tween 20; the mass ratio of the magnolia extract to the deionized water is 1: 10-1: 20.
2. The plant essential oil nanoemulsion of claim 1, characterized in that: the magnolia extract is prepared by the following method: grinding fresh magnolia, extracting with an ethanol solution at 40-60 ℃ to obtain an magnolia extracting solution, removing ethanol, and carrying out vacuum freeze drying on the remaining aqueous solution to obtain the magnolia extract.
3. The plant essential oil nanoemulsion of claim 2, characterized in that: the volume concentration of the ethanol solution is 50-80%.
4. The plant essential oil nanoemulsion of claim 2, characterized in that: the leaching time is 1-2 hours; the volume ratio of the extracted fresh magnolia flower to the ethanol solution is 1: 5-1: 15.
5. The plant essential oil nanoemulsion of claim 2, characterized in that: the ethanol removal is realized by rotary evaporation of the extracting solution at 40-50 ℃.
6. The plant essential oil nanoemulsion of claim 1, characterized in that: the mass ratio of the Span80 to the Tween20 is 9: 1-19: 1.
7. The method for preparing plant essential oil nanoemulsion of claim 1, characterized by comprising the steps of:
1) mixing Span80 with Tween20 to prepare a mixed emulsifier;
2) by mass percentage, 40.0-70.0 percent of cocoa butter, 10.0-25.0 percent of avocado oil, 5.0-15.0 percent of sweet almond oil, 5.0-10.0 percent of coconut oil, 5.0-10.0 percent of safflower seed oil and 3.0-6.0 percent of rose essential oil are uniformly mixed to be used as an oil phase;
3) taking the magnolia flower extract and deionized water as water phases, and controlling the mass ratio of the magnolia flower extract to the deionized water to be 1: 10-1: 20;
4) dispersing an emulsifier in the uniformly mixed oil phase at room temperature, and adding the water phase into the oil phase added with the emulsifier; obtaining an oil phase-water phase-emulsifier mixture;
5) stirring the obtained oil phase-water phase-emulsifier mixture at the stirring speed of 400-800 rpm for 10-30 minutes to prepare a coarse emulsion;
6) heating the crude emulsion to 75-85 ℃, keeping the temperature constant for 5-8 minutes, then placing the emulsion at room temperature for natural cooling to obtain the plant essential oil nano emulsion, and determining the particle size diameter of the prepared plant essential oil nano emulsion to be 20-40 nm by using a laser particle size distribution instrument.
8. Use of a plant essential oil nanoemulsion of claim 1 in a lip care product, characterized by: the lip care product is lip glaze, lipstick, lip gloss, lip oil or lipstick.
9. Use of a plant essential oil nanoemulsion according to claim 8 in a lip care product, characterized in that: the lip glaze is prepared by the following method: by mass percentage, 55.9 to 88.6 percent of plant essential oil nano emulsion, 1.0 to 4.0 percent of squalane, 0.1 to 0.4 percent of vitamin E and 10.0 to 40.0 percent of polyisobutene are uniformly mixed.
10. Use of a plant essential oil nanoemulsion according to claim 8 in a lip care product, characterized in that: the lipstick is prepared by the following method: by mass percentage, 52.9 to 80.6 percent of plant essential oil nano emulsion, 1.0 to 4.0 percent of squalane, 0.1 to 0.4 percent of vitamin E, 10.0 to 40.0 percent of polyisobutylene and 3.0 to 8.0 percent of beeswax are evenly mixed.
CN202010686317.0A 2020-07-16 2020-07-16 Plant essential oil nano emulsion, preparation method thereof and application thereof in lip products Active CN111803415B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010686317.0A CN111803415B (en) 2020-07-16 2020-07-16 Plant essential oil nano emulsion, preparation method thereof and application thereof in lip products

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010686317.0A CN111803415B (en) 2020-07-16 2020-07-16 Plant essential oil nano emulsion, preparation method thereof and application thereof in lip products

Publications (2)

Publication Number Publication Date
CN111803415A true CN111803415A (en) 2020-10-23
CN111803415B CN111803415B (en) 2023-02-17

Family

ID=72864982

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010686317.0A Active CN111803415B (en) 2020-07-16 2020-07-16 Plant essential oil nano emulsion, preparation method thereof and application thereof in lip products

Country Status (1)

Country Link
CN (1) CN111803415B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112641679A (en) * 2020-12-29 2021-04-13 广州环亚化妆品科技有限公司 Microcapsule and preparation method and application thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080260869A1 (en) * 2007-04-19 2008-10-23 Mary Kay Inc. Magnolia extract containing compositions
CN106619313A (en) * 2017-01-16 2017-05-10 广州市花安堂生物科技有限公司 Water-in-oil type lip mask and preparation method thereof
CN106727208A (en) * 2016-11-25 2017-05-31 南通博泰美术图案设计有限公司 Lipstick
CN107157824A (en) * 2017-05-08 2017-09-15 广州赛莱拉干细胞科技股份有限公司 A kind of antioxidant composition and cosmetics and application
WO2018113447A1 (en) * 2016-12-22 2018-06-28 张文健 Magnolia essence nutritional skincare aloe vera gel
CN108670882A (en) * 2018-07-23 2018-10-19 长江师范学院 A kind of edible lipstick and preparation method thereof
CN109157423A (en) * 2018-09-30 2019-01-08 广州启正化工科技有限公司 A kind of preparation method and application of water-in-oil nano-emulsion
CN109248113A (en) * 2018-11-27 2019-01-22 花安堂生物科技集团有限公司 A kind of emulsification lip gloss and preparation method thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080260869A1 (en) * 2007-04-19 2008-10-23 Mary Kay Inc. Magnolia extract containing compositions
CN106727208A (en) * 2016-11-25 2017-05-31 南通博泰美术图案设计有限公司 Lipstick
WO2018113447A1 (en) * 2016-12-22 2018-06-28 张文健 Magnolia essence nutritional skincare aloe vera gel
CN106619313A (en) * 2017-01-16 2017-05-10 广州市花安堂生物科技有限公司 Water-in-oil type lip mask and preparation method thereof
CN107157824A (en) * 2017-05-08 2017-09-15 广州赛莱拉干细胞科技股份有限公司 A kind of antioxidant composition and cosmetics and application
CN108670882A (en) * 2018-07-23 2018-10-19 长江师范学院 A kind of edible lipstick and preparation method thereof
CN109157423A (en) * 2018-09-30 2019-01-08 广州启正化工科技有限公司 A kind of preparation method and application of water-in-oil nano-emulsion
CN109248113A (en) * 2018-11-27 2019-01-22 花安堂生物科技集团有限公司 A kind of emulsification lip gloss and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李红双等: "天然花卉防晒成分提取及应用研究", 《安徽农业科学》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112641679A (en) * 2020-12-29 2021-04-13 广州环亚化妆品科技有限公司 Microcapsule and preparation method and application thereof

Also Published As

Publication number Publication date
CN111803415B (en) 2023-02-17

Similar Documents

Publication Publication Date Title
CN107281031B (en) Long-acting moisturizing, nourishing and injury repairing lip balm and preparation method thereof
JP4693963B2 (en) Estrogen-like agent, collagen production promoter, and fibroblast proliferating agent
CN111481481B (en) Spun gold royal chrysanthemum nanotechnology skin care product and preparation method and application thereof
CN102920646B (en) Nourishing moisture-retention emulsion and preparation method thereof
KR20200029981A (en) Composition for Prevention or Improving of Atopic Dermatitis and manufacturing method thereof
CN106726917B (en) A kind of eyeware products and solution for lenses and contact lenses
CN104434650A (en) Whitening, moisturizing and energizing emulsion capable of calming emotions and smoothing pressure and preparation method thereof
CN106309165A (en) Plant essential oil skin cream and preparation method thereof
CN103989601A (en) Shining, moisturizing and skin-finishing cream and preparation method thereof
CN111803415B (en) Plant essential oil nano emulsion, preparation method thereof and application thereof in lip products
JP3370289B2 (en) Cosmetic and method for producing cosmetic
KR100941854B1 (en) Composition for skin external use containing omega-3 fatty acids
CN107496286B (en) Water-replenishing and moistening type water emulsion capable of fading fine wrinkles and preparation method thereof
KR20200108207A (en) A method for extracting fat soluble solvent of Loquat leaf (Eriobotrya japonica Lindley) and Taraxaci Herba(Taraxacum platycarpum) for use as a cosmetic composition
CN111631984B (en) Makeup removing cream and preparation method thereof
CN112494350B (en) Organic emulsion and preparation method thereof
KR100667182B1 (en) Cosmetics for improvement xeroderma containing badger oil
CN113425661A (en) Plant composition with cleaning and repairing effects and application thereof
CN108379212B (en) Camel milk moisturizing cream with anti-aging effect and preparation method thereof
RU2571273C1 (en) Biologically active composition for intensive moisturising and lifting effect of skin
JP5855949B2 (en) Keratin production promoter, hair dye and nail polish
JP2008169196A (en) External preparation for skin
CN111388360A (en) Bathing essential oil and preparation method thereof
CN104873438A (en) Cream capable of refreshing and moistening skin and preparation method therefor
CN111658597B (en) Yoghourt-containing moisturizing composition and preparation thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant