CN112639078B - 用于雄性不育的生物传感器 - Google Patents
用于雄性不育的生物传感器Info
- Publication number
- CN112639078B CN112639078B CN201980055564.6A CN201980055564A CN112639078B CN 112639078 B CN112639078 B CN 112639078B CN 201980055564 A CN201980055564 A CN 201980055564A CN 112639078 B CN112639078 B CN 112639078B
- Authority
- CN
- China
- Prior art keywords
- biosensor
- sperm
- substrate
- leu
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/0612—Germ cells sorting of gametes, e.g. according to sex or motility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Electrochemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18190720.5 | 2018-08-24 | ||
| EP18190720 | 2018-08-24 | ||
| PCT/EP2019/072574 WO2020039064A1 (en) | 2018-08-24 | 2019-08-23 | Biosensor for male infertility |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112639078A CN112639078A (zh) | 2021-04-09 |
| CN112639078B true CN112639078B (zh) | 2025-11-07 |
Family
ID=63405057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980055564.6A Active CN112639078B (zh) | 2018-08-24 | 2019-08-23 | 用于雄性不育的生物传感器 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20210325370A1 (https=) |
| EP (1) | EP3768825B1 (https=) |
| JP (1) | JP7168265B2 (https=) |
| KR (1) | KR102594453B1 (https=) |
| CN (1) | CN112639078B (https=) |
| AU (1) | AU2019325300B2 (https=) |
| BR (1) | BR112021001488A2 (https=) |
| DK (1) | DK3768825T3 (https=) |
| EA (1) | EA202190166A1 (https=) |
| ES (1) | ES2889973T3 (https=) |
| IL (1) | IL280445B2 (https=) |
| MX (1) | MX2021002145A (https=) |
| PL (1) | PL3768825T3 (https=) |
| SG (1) | SG11202100358VA (https=) |
| WO (1) | WO2020039064A1 (https=) |
| ZA (1) | ZA202100472B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240003911A1 (en) * | 2020-11-23 | 2024-01-04 | The University Of Toledo | Quantification of sperm centriole quality |
| EP4713691A1 (en) * | 2023-05-16 | 2026-03-25 | Technion Research & Development Foundation Limited | Method of determining fusogenic potential of sperm and use thereof in assisted fertilization and drug screening |
| CN116773427A (zh) * | 2023-07-25 | 2023-09-19 | 香港大学深圳医院 | 通过流式细胞术检测精子体外受精能力的方法 |
| CN120741585B (zh) * | 2025-08-28 | 2025-11-11 | 华中科技大学 | 一种精子质量检测传感器及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108152189A (zh) * | 2017-12-06 | 2018-06-12 | 浙江大学 | 一种精子表面出云蛋白1的定量检测方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1056858B1 (en) | 1998-02-19 | 2004-12-08 | Eastern Virginia Medical School | RECOMBINANT ACTIVE HUMAN ZONA PELLUCIDA PROTEIN 3 (hZP3) |
| US6649419B1 (en) * | 2000-11-28 | 2003-11-18 | Large Scale Proteomics Corp. | Method and apparatus for protein manipulation |
| WO2003011118A2 (en) | 2001-08-02 | 2003-02-13 | Trinity Biomedical Technology Corporation | Human zona pellucida proteins and methods of their use in diagnosing male infertility |
| WO2006108183A2 (en) * | 2005-04-05 | 2006-10-12 | Corning Incorporated | Label free biosensors and cells |
| WO2008026906A1 (es) * | 2006-08-25 | 2008-03-06 | Instituto Nacional De Ciencias Médicas Y Nutrición Salvador Zubirán | Ensayo de captura de espermatozoides utilizando las proteinas zp2, zp3 y zp4 |
| EP2255204B1 (en) | 2008-03-20 | 2013-11-06 | Tidhar Zanbar | Method and kit for diagnosis of male fertility |
| WO2013012749A2 (en) | 2011-07-15 | 2013-01-24 | The Curators Of The University Of Missouri | Human zona pellucida glycoproteins, their oligosaccharides, and uses thereof |
| JP5954800B2 (ja) | 2012-02-17 | 2016-07-20 | 国立研究開発法人産業技術総合研究所 | 男性不妊症の原因因子検出方法及び男性不妊症モデル動物 |
| RU2487705C1 (ru) * | 2012-03-21 | 2013-07-20 | ОКТАПАМ Лимитед | Средство для улучшения репродуктивной функции |
| SG11201603225YA (en) * | 2013-11-04 | 2016-05-30 | Agency Science Tech & Res | Optical sensing device for surface plasmon resonance (spr) and optical sensing method using surface plasmon resonance (spr) |
| CN106033086B (zh) | 2015-03-17 | 2018-03-09 | 中国科学院宁波材料技术与工程研究所 | 基于lspr检测精子顶体酶活性的方法、试剂盒及其应用 |
| US20170219554A1 (en) * | 2016-01-29 | 2017-08-03 | Mara Nanotech New York, Inc. | Apparatus and method for detecting analytes in solution |
-
2019
- 2019-08-23 KR KR1020217008528A patent/KR102594453B1/ko active Active
- 2019-08-23 MX MX2021002145A patent/MX2021002145A/es unknown
- 2019-08-23 ES ES19759542T patent/ES2889973T3/es active Active
- 2019-08-23 PL PL19759542T patent/PL3768825T3/pl unknown
- 2019-08-23 SG SG11202100358VA patent/SG11202100358VA/en unknown
- 2019-08-23 WO PCT/EP2019/072574 patent/WO2020039064A1/en not_active Ceased
- 2019-08-23 EA EA202190166A patent/EA202190166A1/ru unknown
- 2019-08-23 DK DK19759542.4T patent/DK3768825T3/da active
- 2019-08-23 IL IL280445A patent/IL280445B2/en unknown
- 2019-08-23 US US17/260,609 patent/US20210325370A1/en not_active Abandoned
- 2019-08-23 AU AU2019325300A patent/AU2019325300B2/en active Active
- 2019-08-23 JP JP2021507472A patent/JP7168265B2/ja active Active
- 2019-08-23 CN CN201980055564.6A patent/CN112639078B/zh active Active
- 2019-08-23 EP EP19759542.4A patent/EP3768825B1/en active Active
- 2019-08-23 BR BR112021001488-8A patent/BR112021001488A2/pt unknown
-
2021
- 2021-01-22 ZA ZA2021/00472A patent/ZA202100472B/en unknown
- 2021-10-01 US US17/492,331 patent/US11782052B2/en active Active
-
2025
- 2025-03-27 US US19/092,356 patent/US20250306010A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108152189A (zh) * | 2017-12-06 | 2018-06-12 | 浙江大学 | 一种精子表面出云蛋白1的定量检测方法 |
Non-Patent Citations (1)
| Title |
|---|
| Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex;Halil Aydin 等;《NATURE》;20160601;摘要，方法中Protein expression and purification和Biolayer interferometry (BLI)部分 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2021002145A (es) | 2021-04-28 |
| EP3768825A1 (en) | 2021-01-27 |
| CN112639078A (zh) | 2021-04-09 |
| US20220026413A1 (en) | 2022-01-27 |
| PL3768825T3 (pl) | 2021-12-06 |
| CA3109529A1 (en) | 2020-02-27 |
| KR20210049134A (ko) | 2021-05-04 |
| ZA202100472B (en) | 2022-07-27 |
| US20210325370A1 (en) | 2021-10-21 |
| EA202190166A1 (ru) | 2021-05-28 |
| BR112021001488A2 (pt) | 2021-04-27 |
| EP3768825B1 (en) | 2021-08-11 |
| AU2019325300A1 (en) | 2021-04-15 |
| JP7168265B2 (ja) | 2022-11-09 |
| DK3768825T3 (da) | 2021-09-20 |
| IL280445A (en) | 2021-03-01 |
| IL280445B2 (en) | 2025-11-01 |
| ES2889973T3 (es) | 2022-01-14 |
| AU2019325300B2 (en) | 2023-10-05 |
| US20250306010A1 (en) | 2025-10-02 |
| KR102594453B1 (ko) | 2023-10-25 |
| SG11202100358VA (en) | 2021-04-29 |
| US11782052B2 (en) | 2023-10-10 |
| WO2020039064A1 (en) | 2020-02-27 |
| JP2021535366A (ja) | 2021-12-16 |
| IL280445B1 (en) | 2025-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TG01 | Patent term adjustment | ||
| TG01 | Patent term adjustment |