JP7168265B2 - 雄不妊のためのバイオセンサ - Google Patents

雄不妊のためのバイオセンサ Download PDF

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JP7168265B2
JP7168265B2 JP2021507472A JP2021507472A JP7168265B2 JP 7168265 B2 JP7168265 B2 JP 7168265B2 JP 2021507472 A JP2021507472 A JP 2021507472A JP 2021507472 A JP2021507472 A JP 2021507472A JP 7168265 B2 JP7168265 B2 JP 7168265B2
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sperm
biosensor
sample
juno
protein
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JP2021535366A5 (https=
JPWO2020039064A5 (https=
JP2021535366A (ja
Inventor
プンヤニ，クシャグル
スリヴァスタヴァ，スダ
タクワ，モハマド
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スパーモセンス エービー
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0612—Germ cells sorting of gametes, e.g. according to sex or motility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2021507472A 2018-08-24 2019-08-23 雄不妊のためのバイオセンサ Active JP7168265B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18190720.5 2018-08-24
EP18190720 2018-08-24
PCT/EP2019/072574 WO2020039064A1 (en) 2018-08-24 2019-08-23 Biosensor for male infertility

Publications (4)

Publication Number Publication Date
JP2021535366A JP2021535366A (ja) 2021-12-16
JP2021535366A5 JP2021535366A5 (https=) 2022-08-25
JPWO2020039064A5 JPWO2020039064A5 (https=) 2022-08-25
JP7168265B2 true JP7168265B2 (ja) 2022-11-09

Family

ID=63405057

Family Applications (1)

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JP2021507472A Active JP7168265B2 (ja) 2018-08-24 2019-08-23 雄不妊のためのバイオセンサ

Country Status (16)

Country Link
US (3) US20210325370A1 (https=)
EP (1) EP3768825B1 (https=)
JP (1) JP7168265B2 (https=)
KR (1) KR102594453B1 (https=)
CN (1) CN112639078B (https=)
AU (1) AU2019325300B2 (https=)
BR (1) BR112021001488A2 (https=)
DK (1) DK3768825T3 (https=)
EA (1) EA202190166A1 (https=)
ES (1) ES2889973T3 (https=)
IL (1) IL280445B2 (https=)
MX (1) MX2021002145A (https=)
PL (1) PL3768825T3 (https=)
SG (1) SG11202100358VA (https=)
WO (1) WO2020039064A1 (https=)
ZA (1) ZA202100472B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240003911A1 (en) * 2020-11-23 2024-01-04 The University Of Toledo Quantification of sperm centriole quality
EP4713691A1 (en) * 2023-05-16 2026-03-25 Technion Research & Development Foundation Limited Method of determining fusogenic potential of sperm and use thereof in assisted fertilization and drug screening
CN116773427A (zh) * 2023-07-25 2023-09-19 香港大学深圳医院 通过流式细胞术检测精子体外受精能力的方法
CN120741585B (zh) * 2025-08-28 2025-11-11 华中科技大学 一种精子质量检测传感器及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148930A1 (en) 2001-08-02 2003-08-07 Ting-Fung Chi Human zona pellucida proteins and methods of their use in diagnoising male infertility
WO2008026906A1 (es) 2006-08-25 2008-03-06 Instituto Nacional De Ciencias Médicas Y Nutrición Salvador Zubirán Ensayo de captura de espermatozoides utilizando las proteinas zp2, zp3 y zp4
JP2011515677A (ja) 2008-03-20 2011-05-19 ザンバー，ティドハー 男性の生殖能診断用の方法及びキット
WO2013122265A1 (ja) 2012-02-17 2013-08-22 独立行政法人産業技術総合研究所 男性不妊症の原因因子検出方法及び男性不妊症モデル動物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1056858B1 (en) 1998-02-19 2004-12-08 Eastern Virginia Medical School RECOMBINANT ACTIVE HUMAN ZONA PELLUCIDA PROTEIN 3 (hZP3)
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
WO2006108183A2 (en) * 2005-04-05 2006-10-12 Corning Incorporated Label free biosensors and cells
WO2013012749A2 (en) 2011-07-15 2013-01-24 The Curators Of The University Of Missouri Human zona pellucida glycoproteins, their oligosaccharides, and uses thereof
RU2487705C1 (ru) * 2012-03-21 2013-07-20 ОКТАПАМ Лимитед Средство для улучшения репродуктивной функции
SG11201603225YA (en) * 2013-11-04 2016-05-30 Agency Science Tech & Res Optical sensing device for surface plasmon resonance (spr) and optical sensing method using surface plasmon resonance (spr)
CN106033086B (zh) 2015-03-17 2018-03-09 中国科学院宁波材料技术与工程研究所 基于lspr检测精子顶体酶活性的方法、试剂盒及其应用
US20170219554A1 (en) * 2016-01-29 2017-08-03 Mara Nanotech New York, Inc. Apparatus and method for detecting analytes in solution
CN108152189B (zh) * 2017-12-06 2020-06-05 浙江大学 一种精子表面出云蛋白1的定量检测方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148930A1 (en) 2001-08-02 2003-08-07 Ting-Fung Chi Human zona pellucida proteins and methods of their use in diagnoising male infertility
WO2008026906A1 (es) 2006-08-25 2008-03-06 Instituto Nacional De Ciencias Médicas Y Nutrición Salvador Zubirán Ensayo de captura de espermatozoides utilizando las proteinas zp2, zp3 y zp4
JP2011515677A (ja) 2008-03-20 2011-05-19 ザンバー，ティドハー 男性の生殖能診断用の方法及びキット
WO2013122265A1 (ja) 2012-02-17 2013-08-22 独立行政法人産業技術総合研究所 男性不妊症の原因因子検出方法及び男性不妊症モデル動物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Enrica Bianchi et al.，Juno is the egg Izumo receptor and is essential for mammalian fertilization，Nature，2014年04月24日，Vol.508，PP.483-487
HALIL AYDIN et al.，Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex ，Nature ，2016年06月01日，Vol.534,No.7608，PP.562-565
KATERINA GEORGADAKI et al.，The molecular basis of fertilization (Review)，INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE，2016年08月31日，Vol.38,No.4，PP.979-986
YU MENGURU et al.，Mutational analysis of IZUMO1R in women with fertiilization failure and polyspermy after in vitro feritilization，journal of assisted reproduction and genetics，2017年12月15日，Vol.35,No.3，PP.539-544

Also Published As

Publication number Publication date
MX2021002145A (es) 2021-04-28
CN112639078B (zh) 2025-11-07
EP3768825A1 (en) 2021-01-27
CN112639078A (zh) 2021-04-09
US20220026413A1 (en) 2022-01-27
PL3768825T3 (pl) 2021-12-06
CA3109529A1 (en) 2020-02-27
KR20210049134A (ko) 2021-05-04
ZA202100472B (en) 2022-07-27
US20210325370A1 (en) 2021-10-21
EA202190166A1 (ru) 2021-05-28
BR112021001488A2 (pt) 2021-04-27
EP3768825B1 (en) 2021-08-11
AU2019325300A1 (en) 2021-04-15
DK3768825T3 (da) 2021-09-20
IL280445A (en) 2021-03-01
IL280445B2 (en) 2025-11-01
ES2889973T3 (es) 2022-01-14
AU2019325300B2 (en) 2023-10-05
US20250306010A1 (en) 2025-10-02
KR102594453B1 (ko) 2023-10-25
SG11202100358VA (en) 2021-04-29
US11782052B2 (en) 2023-10-10
WO2020039064A1 (en) 2020-02-27
JP2021535366A (ja) 2021-12-16
IL280445B1 (en) 2025-07-01

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