CN112617208A - Anti-fatigue product containing folic acid - Google Patents
Anti-fatigue product containing folic acid Download PDFInfo
- Publication number
- CN112617208A CN112617208A CN202011341961.0A CN202011341961A CN112617208A CN 112617208 A CN112617208 A CN 112617208A CN 202011341961 A CN202011341961 A CN 202011341961A CN 112617208 A CN112617208 A CN 112617208A
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- China
- Prior art keywords
- folic acid
- fatigue
- parts
- containing anti
- fatigue product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title claims abstract description 111
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title claims abstract description 60
- 239000011724 folic acid Substances 0.000 title claims abstract description 60
- 235000019152 folic acid Nutrition 0.000 title claims abstract description 60
- 229960000304 folic acid Drugs 0.000 title claims abstract description 60
- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 53
- 240000004922 Vigna radiata Species 0.000 claims abstract description 24
- 235000010721 Vigna radiata var radiata Nutrition 0.000 claims abstract description 24
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 claims abstract description 24
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 21
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 21
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims abstract description 21
- 150000002224 folic acids Chemical class 0.000 claims abstract description 21
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 20
- 241000220317 Rosa Species 0.000 claims abstract description 19
- 239000000843 powder Substances 0.000 claims description 48
- 239000000047 product Substances 0.000 claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
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- 238000007873 sieving Methods 0.000 claims description 17
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- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims description 7
- 235000008191 folinic acid Nutrition 0.000 claims description 7
- 239000011672 folinic acid Substances 0.000 claims description 7
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims description 7
- 229960001691 leucovorin Drugs 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 229940065207 methylfolic acid Drugs 0.000 claims description 3
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
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- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims 1
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- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 4
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 2
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- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/15—Vitamins
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- A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
- A23L11/05—Mashed or comminuted pulses or legumes; Products made therefrom
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L25/00—Food consisting mainly of nutmeat or seeds; Preparation or treatment thereof
- A23L25/30—Mashed or comminuted products, e.g. pulp, pastes, meal, powders; Products made therefrom, e.g. blocks, flakes, snacks; Liquid or semi-liquid products
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/738—Rosa (rose)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agronomy & Crop Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of health-care and health-preserving foods, and particularly relates to an anti-fatigue product containing folic acid. An anti-fatigue product containing folic acid, which comprises the following components: folic acid compounds, dandelion, rose, lotus seeds and mung beans. The folic acid-containing anti-fatigue product provided by the invention has an obvious anti-fatigue effect, no toxic or side effect and good taste, is extremely suitable for modern people with high pressure and in a fatigue state to eat as leisure food, can effectively relieve the fatigue state of people, and is beneficial to physical and mental health.
Description
Technical Field
The invention belongs to the technical field of health-care and health-preserving foods, and particularly relates to an anti-fatigue product containing folic acid.
Background
Fatigue refers to the inability of the body's physiological processes to sustain a specific level of its function or to maintain a predetermined motor strength. Regarding the mechanism of fatigue development, Edward proposed a "mutation theory" which suggests that global fatigue is not a fixed one or more causes, and is a product of the sum of multiple fatigue-causing factors, and that muscle excitability, energy supply level, and output power gradually decrease before sports fatigue. When the sum of the effects of the various fatigue-causing factors reaches a certain threshold, a sudden drop in excitability, manifested as a sudden breakdown in excitability, a sudden interruption in energy supply, a sudden drop in muscle strength or output power, occurs, and fatigue occurs.
Fatigue is a comprehensive physiological process involving many physiological and biochemical factors, and causes of fatigue include many factors, including working environment, eating habits and life habits, especially diseases, which lead to mental stress, physical strength consumption, weakened resistance of each function of the body and physical strength consumption of drugs, and are very easy to cause fatigue. Fatigue is a normal physiological phenomenon that inevitably occurs when the brain or physical activities of the body reach a certain stage, which not only marks the temporary decline of the original working capacity of the body, but also may be a precursor for the body to develop into an injured state.
Fatigue is a serious hazard, which makes the functions of all the systems of the body at a lower level, reduces the capability of the body to resist foreign pathogens, reduces natural killer cells, and makes people very vulnerable to diseases. Meanwhile, the reduction of natural killer cells of human bodies can greatly increase the occurrence probability of high-risk diseases such as cardiovascular and cerebrovascular diseases, diabetes, cancers and the like. When a human body is in a fatigue state, because the energy of myocardial cells is reduced and physiological fatigue poisons the myocardial cells, the myocardial contraction force is reduced, the blood pumping function of the heart is reduced, blood is deposited in blood vessels, microcirculation disturbance occurs, the blood flow speed is reduced, blood garbage is increased, and various cardiovascular and cerebrovascular diseases are caused. In addition, excessive fatigue can cause "aging acceleration" in the aging process. Chronic Fatigue Syndrome (CFS) among Fatigue symptoms is a group of syndromes which are predominantly manifested by long-term persistent Fatigue and accompanied by nonspecific manifestations such as low fever, headache, sore throat, muscular joint pain, inattention, memory decline, sleep disturbance and depression, and generally has no obvious abnormality in physical examination and routine examination.
The methods for relieving fatigue mostly adjust the body through sleeping and recuperation, and on the other hand, improve the body function by conditioning external substances. However, no anti-fatigue medicine or food with very remarkable effect exists in the current market. Therefore, an anti-fatigue product is researched and developed, the anti-fatigue effect is achieved through daily health care, the modern health preservation concept of 'preventive treatment of disease' is met, the requirements of people can be well met, and the anti-fatigue health-care tea has a wide market prospect.
Disclosure of Invention
In order to overcome the technical problems, the invention provides an anti-fatigue product containing folic acid. The product has good antifatigue effect, and simple preparation method, and can effectively relieve fatigue state of people and promote physical and mental health.
In order to achieve the above purpose, the technical scheme provided by the invention is as follows:
an anti-fatigue product containing folic acid, which comprises the following components:
folic acid compounds, dandelion, rose, lotus seeds and mung beans.
Preferably, the folic acid-containing anti-fatigue product comprises the following components in parts by weight: 0.0001-0.0006 part of folic acid compounds, 25-40 parts of dandelion, 20-30 parts of rose, 10-20 parts of lotus seeds and 10-25 parts of mung beans.
Preferably, the folic acid-containing anti-fatigue product comprises the following components in parts by weight: 0.0002-0.0005 part of folic acid compound, 25-30 parts of dandelion, 20-25 parts of rose, 10-15 parts of lotus seed and 10-15 parts of mung bean.
Preferably, the folic acid compounds are one or more of folic acid, leucovorin, L-methyl folic acid, pharmaceutically acceptable salts of folic acid, active metabolites of folic acid or pharmaceutically acceptable salts of folic acid, and substances capable of metabolizing and/or generating folic acid in vivo.
Preferably, the folic acid-containing anti-fatigue product further comprises sucrose, or any one of xylitol, aspartame and stevioside.
Preferably, the product comprises an anti-fatigue product containing folic acid and at least one food-acceptable auxiliary material; the auxiliary materials are one or any combination of excipient, lubricant, suspending agent, preservative, adhesive, disintegrant or antioxidant.
The invention also aims to provide a preparation method of the folic acid-containing anti-fatigue product, which comprises the following steps:
(1) pulverizing semen Nelumbinis and semen Phaseoli Radiati respectively, and sieving; making semen Nelumbinis powder and semen Phaseoli Radiati powder;
(2) cleaning herba Taraxaci and flos Rosae Rugosae, mixing, adding water, decocting, and filtering to obtain primary filtrate and residue;
(3) adding water into the filter residue, decocting, and filtering to obtain secondary filtrate;
(4) mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain water extract;
(5) drying the water extract to obtain dry extract, pulverizing the dry extract, and sieving to obtain dry extract powder;
(6) mixing folic acid compounds with semen Nelumbinis powder, semen Phaseoli Radiati powder, and dry extract powder, and adding adjuvants.
Preferably, in the step (1), the sieved mesh number is 80-100 meshes.
Preferably, in the step (2), the mass of the added water is 8-12 times of the mixed mass of the dandelion and the rose.
Preferably, in the step (2), the decoction time is 1-3 h; preferably for 2 hours.
Preferably, in the step (3), the decoction time is 1-3 h; preferably 1 h.
Preferably, in the step (3), the mass of the added water is 3-5 times of that of the filter residue.
Preferably, in the step (4), the relative density of the water extract at 50 ℃ is 1.15-1.25.
Compared with the prior art, the invention has the technical advantages that:
(1) the folic acid-containing anti-fatigue product provided by the invention has an obvious anti-fatigue effect, no toxic or side effect and good taste, is extremely suitable for modern people with high pressure and in a fatigue state to eat as leisure food, can effectively relieve the fatigue state of people, and is beneficial to physical and mental health.
(2) The mixed extraction of the dandelion and the rose is beneficial to promoting the extraction of effective components and plays a role of synergy.
(3) The addition of folic acid compounds in the invention is beneficial to exerting the synergistic effect of dandelion, rose, lotus seeds and mung beans, and effectively relieving fatigue.
Detailed Description
The present invention will be described below with reference to specific examples to make the technical aspects of the present invention easier to understand and grasp, but the present invention is not limited thereto. The experimental methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials are commercially available, unless otherwise specified.
Example 1
The folic acid-containing anti-fatigue product comprises the following components in parts by weight: 0.0002 part of folic acid compounds, 30 parts of dandelion, 25 parts of rose, 15 parts of lotus seeds and 15 parts of mung beans.
The folic acid compound is leucovorin;
the preparation method of the folic acid-containing anti-fatigue product comprises the following steps:
(1) respectively crushing lotus seeds and mung beans, and sieving by a 80-mesh sieve; making semen Nelumbinis powder and semen Phaseoli Radiati powder;
(2) cleaning herba Taraxaci and flos Rosae Rugosae, mixing, adding water 10 times of the total weight of the two, decocting, and hot filtering to obtain primary filtrate and residue;
(3) adding water with the mass of 4 times of the filter residue, decocting for 1h, and filtering to obtain a secondary filtrate;
(4) mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain water extract with relative density of 1.15 at 50 deg.C;
(5) drying the water extract to obtain dry extract, pulverizing the dry extract, and sieving to obtain dry extract powder;
(6) mixing folic acid compounds with semen Nelumbinis powder, semen Phaseoli Radiati powder, and dry extract powder, and adding sucrose and adjuvants.
Example 2
The folic acid-containing anti-fatigue product comprises the following components in parts by weight: 0.0001 part of folic acid, 40 parts of dandelion, 20 parts of rose, 20 parts of lotus seed and 10 parts of mung bean.
The preparation method of the folic acid-containing anti-fatigue product comprises the following steps:
(1) respectively crushing lotus seeds and mung beans, and sieving the crushed lotus seeds and mung beans by a 100-mesh sieve; making semen Nelumbinis powder and semen Phaseoli Radiati powder;
(2) cleaning and mixing herba Taraxaci and flos Rosae Rugosae, adding water 8 times of the total weight of the herba Taraxaci and flos Rosae Rugosae, decocting, and hot filtering to obtain primary filtrate and residue;
(3) adding 3 times of water into the filter residue, decocting for 1h, and filtering to obtain a secondary filtrate;
(4) mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain water extract with relative density of 1.25 at 50 deg.C;
(5) drying the water extract to obtain dry extract, pulverizing the dry extract, and sieving to obtain dry extract powder;
(6) mixing folic acid, semen Nelumbinis powder, semen Phaseoli Radiati powder, and dry extract powder, adding xylitol and adjuvants.
Example 3
The folic acid-containing anti-fatigue product comprises the following components in parts by weight: 0.0006 part of folic acid compounds, 25 parts of dandelion, 30 parts of rose, 10 parts of lotus seeds and 25 parts of mung beans.
The folic acid compound is L-methyl folic acid.
The preparation method of the folic acid-containing anti-fatigue product comprises the following steps:
(1) respectively crushing lotus seeds and mung beans, and sieving the crushed lotus seeds and mung beans by a 100-mesh sieve; making semen Nelumbinis powder and semen Phaseoli Radiati powder;
(2) cleaning and mixing herba Taraxaci and flos Rosae Rugosae, adding water 12 times of the total weight of the herba Taraxaci and flos Rosae Rugosae, decocting, and hot filtering to obtain primary filtrate and residue;
(3) adding 5 times of water into the filter residue, decocting for 3h, and filtering to obtain a secondary filtrate;
(4) mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain water extract with relative density of 1.18 at 50 deg.C;
(5) drying the water extract to obtain dry extract, pulverizing the dry extract, and sieving to obtain dry extract powder;
(6) mixing folic acid compounds with semen Nelumbinis powder, semen Phaseoli Radiati powder, and dry extract powder, and adding stevioside and adjuvants.
Comparative example 1
The composition was different compared to example 1.
The folic acid-containing anti-fatigue product comprises the following components in parts by weight: 0.0002 part of folic acid compound, 30 parts of dandelion, 25 parts of chrysanthemum, 15 parts of lotus seed and 15 parts of mung bean.
The folic acid compound is leucovorin;
the preparation method of the folic acid-containing anti-fatigue product comprises the following steps:
(1) respectively crushing lotus seeds and mung beans, and sieving by a 80-mesh sieve; making semen Nelumbinis powder and semen Phaseoli Radiati powder;
(2) cleaning and mixing herba Taraxaci and flos Chrysanthemi, adding water 10 times of the total weight of the two, decocting, and filtering while hot to obtain primary filtrate and residue;
(3) adding water with the mass of 4 times of the filter residue, decocting for 1h, and filtering to obtain a secondary filtrate;
(4) mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain water extract with relative density of 1.15 at 50 deg.C;
(5) drying the water extract to obtain dry extract, pulverizing the dry extract, and sieving to obtain dry extract powder;
(6) mixing folic acid compounds with semen Nelumbinis powder, semen Phaseoli Radiati powder, and dry extract powder, and adding sucrose and adjuvants.
Comparative example 2
The composition was different compared to example 1.
The folic acid-containing anti-fatigue product comprises the following components in parts by weight: 0.0002 part of folic acid compounds, 30 parts of dandelion, 25 parts of rose, 15 parts of red dates and 15 parts of mung beans.
The folic acid compound is leucovorin;
the preparation method of the folic acid-containing anti-fatigue product comprises the following steps:
(1) respectively crushing red dates and mung beans, and sieving the crushed red dates and mung beans by a 80-mesh sieve; making fructus Jujubae powder and semen Phaseoli Radiati powder;
(2) cleaning herba Taraxaci and flos Rosae Rugosae, mixing, adding water 10 times of the total weight of the two, decocting, and hot filtering to obtain primary filtrate and residue;
(3) adding water with the mass of 4 times of the filter residue, decocting for 1h, and filtering to obtain a secondary filtrate;
(4) mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain water extract with relative density of 1.15 at 50 deg.C;
(5) drying the water extract to obtain dry extract, pulverizing the dry extract, and sieving to obtain dry extract powder;
(6) mixing folic acid compounds with fructus Jujubae powder, semen Phaseoli Radiati powder, and dry extract powder, and adding sucrose and adjuvants.
Comparative example 3
The component ratios were different compared to example 1.
The folic acid-containing anti-fatigue product comprises the following components in parts by weight: 0.005 part of folic acid compound, 30 parts of dandelion, 25 parts of rose, 15 parts of lotus seed and 15 parts of mung bean.
The folic acid compound is leucovorin;
the preparation method of the folic acid-containing anti-fatigue product has the same steps as example 1.
Comparative example 4
The component ratios were different compared to example 1.
The folic acid-containing anti-fatigue product comprises the following components in parts by weight: 0.0002 part of folic acid compounds, 5 parts of dandelion, 25 parts of rose, 15 parts of lotus seeds and 15 parts of mung beans.
The folic acid compound is leucovorin;
the preparation method of the folic acid-containing anti-fatigue product has the same steps as example 1.
Comparative example 5
The preparation method is different compared to example 1.
An anti-fatigue product containing folic acid was prepared in the same manner as in example 1.
The preparation method of the folic acid-containing anti-fatigue product comprises the following steps:
(1) respectively crushing lotus seeds and mung beans, and sieving by a 80-mesh sieve; making semen Nelumbinis powder and semen Phaseoli Radiati powder;
(2) cleaning herba Taraxaci and flos Rosae Rugosae, respectively adding 10 times of water, decocting, filtering while hot to obtain herba Taraxaci primary filtrate and herba Taraxaci filter residue, and flos Rosae Rugosae primary filtrate and flos Rosae Rugosae filter residue;
(3) respectively adding water with the mass of 4 times of that of the dandelion filter residue and the rose filter residue, decocting for 1 hour respectively, and filtering to obtain a dandelion secondary filtrate and a rose secondary filtrate;
(4) mixing the primary filtrate and the secondary filtrate of herba Taraxaci and flos Rosae Rugosae, and concentrating under reduced pressure to obtain water extract with relative density of 1.15 at 50 deg.C;
(5) drying the water extract to obtain dry extract, pulverizing the dry extract, and sieving to obtain dry extract powder;
(6) mixing folic acid compounds with semen Nelumbinis powder, semen Phaseoli Radiati powder, and dry extract powder, and adding sucrose and adjuvants.
Effect example-mouse anti-fatigue test:
the experimental method comprises the following steps: 90 adult mice (20. + -.2 g) with male and female halves were randomly divided into groups of 10 mice each, each group, according to the blank control group, examples 1 to 3 and comparative examples 1 to 5, and adaptively grown for 1 week. Dispersing the products of the groups of examples 1-3 and comparative examples 1-5 into suspension with normal saline, and performing intragastric administration according to the effective content of 3g/kg (body weight of the mouse), and performing intragastric administration on the same amount of normal saline of a blank control group; daily for 3 weeks 1 time. After each gavage, mice had free access to water. The experiment was performed 30min after gavage on day 21.
According to the weight system of the mouse, lead skins are applied, and 5% of the weight of the lead skins are loaded at the root part of the rat tail; putting the mouse into a swimming box for swimming; at a water depth of 30 cm; carrying out load swimming under the condition of water temperature of 25 ℃, and recording the time from the beginning to exhaustion of the mouse as the swimming time of the mouse; exhaustion standard: the mice were submerged for 10 seconds and could not emerge from the water. After the exhaustion time of the loaded swimming is measured, the mouse is immediately removed from the eyeball to take blood, and the SOD and MDA values in the serum are measured after the serum is prepared by centrifugation.
The anti-fatigue effect is judged by the weight swimming time and the content change of SOD (superoxide dismutase) and MDA (malondialdehyde) in serum. The results are shown in Table 1.
TABLE 1 mouse antifatigue test results
Note: p is less than 0.05 compared with the blank control group; p < 0.01.
Therefore, the anti-fatigue product provided by the invention can prolong the weight swimming time of mice, enhance the skeletal muscle contraction capacity, and simultaneously increase the generation and activity of SOD and reduce the generation of MDA through inhibiting lipid peroxidation and antioxidant defense mechanisms, thereby playing the anti-fatigue role. Meanwhile, the components and the preparation method of the product have great influence on the effect of the product.
The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.
Claims (10)
1. An anti-fatigue product containing folic acid, which comprises the following components:
folic acid compounds, dandelion, rose, lotus seeds and mung beans.
2. The folic acid containing anti-fatigue product of claim 1, which comprises the following components in parts by weight: 0.0001-0.0006 part of folic acid compounds, 25-40 parts of dandelion, 20-30 parts of rose, 10-20 parts of lotus seeds and 10-25 parts of mung beans.
3. The folic acid containing anti-fatigue product of claim 1, which comprises the following components in parts by weight: 0.0002-0.0005 part of folic acid, 25-30 parts of dandelion, 20-25 parts of rose, 10-15 parts of lotus seed and 10-15 parts of mung bean.
4. The folic acid containing anti-fatigue product of claim 1, wherein the folic acid compounds are one or more of folic acid, leucovorin, L-methyl folic acid, pharmaceutically acceptable salts of folic acid, active metabolites of folic acid or pharmaceutically acceptable salts of folic acid, and substances that can be metabolized and/or formed in vivo.
5. The folic acid-containing anti-fatigue product of claim 1, further comprising sucrose, or any one of xylitol, aspartame, and stevia.
6. The folic acid-containing anti-fatigue product of claim 1, comprising the folic acid-containing anti-fatigue product further comprising at least one food-acceptable excipient; the auxiliary materials are one or any combination of excipient, lubricant, suspending agent, preservative, adhesive, disintegrant or antioxidant.
7. A process for the preparation of a folic acid containing anti-fatigue product according to any of the claims 1-6, characterized in that it comprises the following steps:
(1) pulverizing semen Nelumbinis and semen Phaseoli Radiati respectively, and sieving; making semen Nelumbinis powder and semen Phaseoli Radiati powder;
(2) cleaning herba Taraxaci and flos Rosae Rugosae, mixing, adding water, decocting, and filtering to obtain primary filtrate and residue;
(3) adding water into the filter residue, decocting, and filtering to obtain secondary filtrate;
(4) mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain water extract;
(5) drying the water extract to obtain dry extract, pulverizing the dry extract, and sieving to obtain dry extract powder;
(6) mixing folic acid compounds with semen Nelumbinis powder, semen Phaseoli Radiati powder, and dry extract powder, and adding adjuvants.
8. The method for producing a folic acid-containing anti-fatigue product according to claim 7,
in the step (1), the sieving mesh number is 80-100 meshes.
9. The method for producing a folic acid-containing anti-fatigue product according to claim 7,
in the step (2), the mass of the added water is 8-12 times of the mixed mass of the dandelion and the rose;
in the step (2), the decoction time is 1-3 h; preferably for 2 h;
in the step (3), the decoction time is 1-3 h; preferably 1 h;
in the step (3), the added mass is 3-5 times of the mass of the filter residue.
10. The method for producing a folic acid-containing anti-fatigue product according to claim 7,
in the step (4), the relative density of the water extract at 50 ℃ is 1.15-1.25.
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