CN112601746A - 吡唑并嘧啶衍生物及其作为pi3k抑制剂的应用 - Google Patents

吡唑并嘧啶衍生物及其作为pi3k抑制剂的应用 Download PDF

Info

Publication number
CN112601746A
CN112601746A CN201980052343.3A CN201980052343A CN112601746A CN 112601746 A CN112601746 A CN 112601746A CN 201980052343 A CN201980052343 A CN 201980052343A CN 112601746 A CN112601746 A CN 112601746A
Authority
CN
China
Prior art keywords
compound
reaction
added
water
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201980052343.3A
Other languages
English (en)
Other versions
CN112601746B (zh
Inventor
吴成德
黄婧婕
于涛
李婕
龚珍
黎健
陈曙辉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medshine Discovery Inc
Original Assignee
Medshine Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medshine Discovery Inc filed Critical Medshine Discovery Inc
Publication of CN112601746A publication Critical patent/CN112601746A/zh
Application granted granted Critical
Publication of CN112601746B publication Critical patent/CN112601746B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

涉及一种吡唑并嘧啶衍生物，及其在制备治疗与PI3K相关疾病的药物中的应用。具体公开了式(Ι)所示衍生化合物、其互变异构体或其药学上可接受的组合物。

Description

PCT国内申请，说明书已公开。

Claims (18)

  1. PCT国内申请，权利要求书已公开。
CN201980052343.3A 2018-08-21 2019-08-21 吡唑并嘧啶衍生物及其作为pi3k抑制剂的应用 Active CN112601746B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN2018109602300 2018-08-21
CN201810960230 2018-08-21
CN201811184709 2018-10-11
CN2018111847096 2018-10-11
CN2019104121489 2019-05-17
CN201910412148 2019-05-17
CN2019107557019 2019-08-15
CN201910755701 2019-08-15
PCT/CN2019/101741 WO2020038394A1 (zh) 2018-08-21 2019-08-21 吡唑并嘧啶衍生物及其作为pi3k抑制剂的应用

Publications (2)

Publication Number Publication Date
CN112601746A true CN112601746A (zh) 2021-04-02
CN112601746B CN112601746B (zh) 2022-09-16

Family

ID=69591951

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980052343.3A Active CN112601746B (zh) 2018-08-21 2019-08-21 吡唑并嘧啶衍生物及其作为pi3k抑制剂的应用

Country Status (5)

Country Link
US (1) US20220112217A1 (zh)
EP (1) EP3828184A4 (zh)
JP (1) JP2021535907A (zh)
CN (1) CN112601746B (zh)
WO (1) WO2020038394A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021164789A1 (zh) * 2020-02-21 2021-08-26 南京明德新药研发有限公司 一种吡唑并嘧啶类化合物的晶型及其应用
JP2023525383A (ja) * 2020-05-16 2023-06-15 フォチョン・バイオサイエンシーズ・リミテッド キナーゼ阻害剤としての化合物
CN114230598B (zh) * 2021-12-30 2024-07-26 大连联化化学有限公司 一种合成2-取代噻唑-4-硼酸频哪醇酯的工艺方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010151735A2 (en) * 2009-06-25 2010-12-29 Amgen Inc. Heterocyclic compounds and their uses
CN106470996A (zh) * 2014-07-04 2017-03-01 鲁平有限公司 作为pi3k抑制剂的喹嗪酮衍生物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1278748B1 (en) * 2000-04-25 2011-03-23 ICOS Corporation Inhibitors of human phosphatidyl-inositol 3-kinase delta
US7919498B2 (en) * 2007-03-23 2011-04-05 Amgen Inc. Substituted pyrazolo[3,4-d]pyrimidines as PI3K inhibitors
US20110269779A1 (en) * 2008-11-18 2011-11-03 Intellikine, Inc. Methods and compositions for treatment of ophthalmic conditions
KR20120002995A (ko) * 2009-03-24 2012-01-09 길리아드 칼리스토가 엘엘씨 ２―퓨리닐―３―톨릴―퀴나졸리논 유도체의 회전장애 이성질체 및 사용 방법
AP2012006294A0 (en) * 2009-11-05 2012-06-30 Rhizen Pharmaceuticals Sa Novel kinase modulators.
KR102216606B1 (ko) 2012-07-04 2021-02-17 리젠 파마슈티컬스 소시에떼 아노님 선택적 pi3k 델타 억제제

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010151735A2 (en) * 2009-06-25 2010-12-29 Amgen Inc. Heterocyclic compounds and their uses
CN106470996A (zh) * 2014-07-04 2017-03-01 鲁平有限公司 作为pi3k抑制剂的喹嗪酮衍生物

Also Published As

Publication number Publication date
WO2020038394A1 (zh) 2020-02-27
JP2021535907A (ja) 2021-12-23
EP3828184A4 (en) 2022-05-04
US20220112217A1 (en) 2022-04-14
EP3828184A1 (en) 2021-06-02
CN112601746B (zh) 2022-09-16

Similar Documents

Publication Publication Date Title
CN114728968A (zh) 稠合吡啶酮类化合物及其制备方法和应用
CN112601746B (zh) 吡唑并嘧啶衍生物及其作为pi3k抑制剂的应用
CN108738320A (zh) 作为用于治疗心血管疾病的cGMP调节剂的4-氨基-2-(1H-吡唑并[3,4-b]吡啶-3-基)-6-氧代-6,7-二氢-5H-吡咯并[2,3-d]嘧啶衍生物及各自的(1H-吲唑-3-基)衍生物
WO2016112637A1 (zh) Btk抑制剂
CN102256944A (zh) 鞘氨醇-1-磷酸受体拮抗剂
CN112566907A (zh) 作为ret抑制剂的吡唑衍生物
CN113321654B (zh) 作为激酶抑制剂的稠合吡啶酮类化合物
CN114105950B (zh) 吡唑类化合物及其应用
WO2007020936A1 (ja) 抗真菌作用二環性複素環化合物
WO2022100623A1 (zh) 氮取代杂环噻吩类化合物及其用途
CN101868457A (zh) 作为β-分泌酶抑制剂用于治疗的(3-羟基-4-氨基-丁-2-基)-3-(2-噻唑-2-基-吡咯烷-1-羰基)苯甲酰胺衍生物和相关化合物
CN114907341A (zh) 吡啶并嘧啶酮类衍生物及其制备方法和用途
CN113993860A (zh) 作为kras g12c突变蛋白抑制剂的七元杂环类衍生物
WO2018221433A1 (ja) ヘテロアリールアミン誘導体
WO2019029521A1 (zh) 用作雄激素受体拮抗剂的二芳基硫代乙内酰脲化合物
CN111278823B (zh) 作为成纤维细胞生长因子受体抑制剂的杂环化合物
WO2021129817A1 (zh) 具有果糖激酶(khk)抑制作用的嘧啶类化合物
CN114502561A (zh) Lsd1抑制剂
WO2021197467A1 (zh) 多靶点的抗肿瘤化合物及其制备方法和应用
CN115942937A (zh) 嘧啶并环类化合物
WO2022048631A1 (zh) 一种具有抗肿瘤活性的化合物及其用途
CN113354585A (zh) 新型ep4拮抗剂的合成及其在癌症和炎症中的用途
CN112513041B (zh) 三环化合物
JP7299350B2 (ja) Ｒｉｐ－１キナーゼ阻害剤としての二環式化合物およびその使用
WO2021129841A1 (zh) 用作ret激酶抑制剂的化合物及其应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40039349

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant