CN112557267A - Blood sedimentation detection device and detection method thereof - Google Patents

Blood sedimentation detection device and detection method thereof Download PDF

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Publication number
CN112557267A
CN112557267A CN202011566664.6A CN202011566664A CN112557267A CN 112557267 A CN112557267 A CN 112557267A CN 202011566664 A CN202011566664 A CN 202011566664A CN 112557267 A CN112557267 A CN 112557267A
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blood
detected
detection
sedimentation
shaped container
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CN112557267B (en
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李建平
李柠
万嫩
白雪
何立栋
温建明
胡意立
蔡俊杰
明禹彤
张云天
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Zhejiang Normal University CJNU
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/04Investigating sedimentation of particle suspensions
    • G01N15/05Investigating sedimentation of particle suspensions in blood
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention belongs to the field of erythrocyte sedimentation rate detection, and particularly relates to an erythrocyte sedimentation rate detection device and an erythrocyte sedimentation rate detection method. The invention solves the problems that the existing Welch method for detecting the blood sedimentation is complex, wastes time and labor, the detecting instrument of the blood sedimentation instrument has high cost and large structure, is difficult to realize miniaturization and portability, and the inclined tube method is only applied under specific conditions and has low detection quality. The blood sedimentation detection device is composed of a detection module, a control module and a display module. The invention is based on the bioelectrical impedance detection principle, adopts a T-shaped container as a container for detecting blood to be detected, calculates a real-time impedance value by detecting a voltage and current signal in a sedimentation process, and further obtains a blood sedimentation detection result.

Description

Blood sedimentation detection device and detection method thereof
Technical Field
The invention relates to the field of biomedical detection, in particular to a blood sedimentation detection device and a detection method thereof.
Background
Erythrocyte sedimentation rate is an index of erythrocyte sedimentation rate under certain conditions, and is called erythrocyte sedimentation for short. The erythrocyte sedimentation rate of a healthy person usually fluctuates up and down within a narrow range, and does not have large ascending and descending changes, and under the interference of many cases, the erythrocyte sedimentation rate shows obvious increase. The erythrocyte sedimentation rate measurement is widely applied clinically, the result of erythrocyte sedimentation and clinical data are mutually contrasted to show that the erythrocyte sedimentation rate measurement has a plurality of applications in clinic, can assist in judging whether a patient organism has inflammation or not, whether a patient lesion has activity or not and the like, can provide parameters for clinical examination with important reference value, and a method of erythrocyte sedimentation rate detection is also commonly adopted as a test diagnosis mode clinically.
The Wei's method is the most classical and most traditional and most conventional and reliable method for detecting the blood sedimentation, and the Wei's method is also a conventional method recommended by the International Committee for standardization of hematology, but in practical application, the Wei's method is complex in process, needs manual operation, can only measure the final result of the blood sedimentation at a certain moment, is poor in specificity, has great limitation in application, and has strict requirements on the time for observing and recording. People have been seeking a simpler and more trouble-saving method for measuring the blood sedimentation in recent years, and the method is more familiar in that a blood sedimentation instrument is adopted, the blood sedimentation instrument can dynamically record the change of the whole blood sedimentation process, draw a curve of the erythrocyte sedimentation and reflect different diseases or different orders of the diseases, the method is more convenient and the detection time is not long, but the obtained detection result is influenced by a plurality of external factors, the cost of the instrument is higher, the instrument can not be popularized in all hospitals, and the instrument is large in size and cannot be carried. The inclined tube method can accelerate the blood sedimentation and shorten the inspection time, the result can be obtained only in 15 minutes, compared with the Weishi method, the waiting time of a patient can be greatly reduced, the blood taking amount can be reduced by 1/3 compared with the Weishi blood sedimentation method, the defects still exist, the complete contrast can not be realized with the Weishi method, the inclined tube method is only suitable for patients with high blood sedimentation under specific conditions, and has great limitation, and meanwhile, the change of the blood sedimentation process has important value for judging diseases, and the inclined tube method can not monitor the change of the blood sedimentation process.
Disclosure of Invention
The present invention is directed to a blood sedimentation detecting device and a detecting method thereof, so as to solve the above problems in the prior art. The invention provides the erythrocyte sedimentation rate detection device and the erythrocyte sedimentation rate detection method which are simple, convenient and quick, have wide applicability and high accuracy and can monitor the erythrocyte sedimentation rate process in real time, and the erythrocyte sedimentation rate detection device and the erythrocyte sedimentation rate detection method are convenient to realize miniaturization and portability.
The above object of the present invention is achieved by the following technical solutions:
a blood sedimentation detection device comprises a detection module, a control module and a display module, wherein the detection module comprises a T-shaped container and an electrode, the control module comprises a controller, and the display module comprises a shell and a display screen; the T-shaped container is used for containing blood to be detected, and the electrode is used for applying a current signal and a detection voltage signal to the blood to be detected; the controller is used for realizing signal sending, signal receiving, data processing and storage, and stores a pre-calibrated value of the corresponding relation between the blood electrical impedance value and the blood sedimentation; the display module is used for receiving and displaying the image-text signal.
Furthermore, the detection module adopts a T-shaped container as a container for detecting blood to be detected, the electrode is integrated in the vertical part at the lower side of the T-shaped container, and the T-shaped container can be taken out of the shell.
A detection method of a blood sedimentation detection device is based on a bioelectrical impedance detection principle and comprises the following steps:
s1: blood test to be tested
S1.1: injecting blood to be tested into a T-shaped container;
s1.2: the controller sends out a high-frequency current signal, transmits the high-frequency current signal to the electrode and loads the high-frequency current signal to the blood to be detected through the electrode;
s1.3: the electrode detects a voltage signal of blood to be detected and transmits the detected voltage signal to the controller;
s2: calculation and processing of signal data
S2.1: calculating an electrical impedance value by using a formula Z = U/I, wherein Z is the electrical impedance of the blood to be detected, I is the current loaded to the blood to be detected, and U is the detected corresponding voltage of the blood to be detected;
s2.2: the controller compares and fits the calculated blood electrical impedance value to be detected with a blood electrical impedance value and a blood sedimentation corresponding value which are stored in the controller in advance, so as to obtain a blood sedimentation detection result of the blood sample to be detected, and transmits the result to the display module;
s3: display of detection result
And S3.1, the display screen receives the detection result and displays the detection result on the screen.
The invention has the beneficial effects that: the blood sedimentation detection device and the detection method thereof are provided, a T-shaped container is adopted as a container for blood detection, the impedance value obtained by the detection of the T-shaped container has a linear relation with the blood sedimentation, the blood sedimentation detection process can be greatly shortened, and the simple, convenient and quick detection is realized; the invention carries out the blood sedimentation detection based on the bioelectrical impedance detection principle, calculates the real-time impedance value by detecting the voltage and current signals in the blood sedimentation process, and then obtains and displays the blood sedimentation detection result by comparing and fitting the real-time impedance value with the pre-calibrated value of the corresponding relation between the blood impedance value and the blood sedimentation.
Drawings
FIG. 1 is a schematic diagram of a blood sedimentation detecting apparatus;
FIG. 2 is a schematic structural view of a T-shaped container;
FIG. 3 is a schematic diagram of a blood sedimentation detection method.
In the figure:
1. a display module; 2. a detection module; 3. a control module; 1-1. displaying a screen; a T-shaped container; 2-2. electrode.
Detailed Description
The details of the present invention and its embodiments are further described below with reference to the accompanying drawings.
Referring to fig. 1 to 3, a blood sedimentation detecting apparatus includes a detecting module (2), a control module (3) and a display module (1), the detecting module (2) includes a T-shaped container (2-1) and an electrode (2-2), the control module (3) includes a controller, the display module (1) includes a housing and a display screen (1-1); the T-shaped container (2-1) is used for containing blood to be detected, and the electrode (2-2) is used for applying a current signal and a detection voltage signal to the blood to be detected; the controller of the control module (3) is used for realizing signal sending, receiving, data processing and storing, and stores a pre-calibrated value of the corresponding relation between the blood electrical impedance value and the blood sedimentation; the display module (1) is used for receiving and displaying the image-text signals.
Furthermore, the detection module (2) adopts a T-shaped container (2-1) as a container for detecting blood to be detected, the electrode (2-2) is integrated in the vertical part at the lower side of the T-shaped container (2-1), and the T-shaped container (2-1) can be taken out of the shell.
A detection method of a blood sedimentation detection device is based on a bioelectrical impedance detection principle and comprises the following steps:
s1: blood test to be tested
S1.1: injecting blood to be tested into a T-shaped container (2-1);
s1.2: the controller sends out a high-frequency current signal, the high-frequency current signal is transmitted to the electrode (2-2), and the high-frequency current signal is loaded to blood to be detected through the electrode (2-2);
s1.3: the electrode (2-2) detects a voltage signal of blood to be detected and transmits the detected voltage signal to the controller;
s2: calculation and processing of signal data
S2.1: calculating an electrical impedance value by using a formula Z = U/I, wherein Z is the electrical impedance of the blood to be detected, I is the current loaded to the blood to be detected, and U is the detected corresponding voltage of the blood to be detected;
s2.2: the controller compares and fits the calculated blood electrical impedance value to be detected with a blood electrical impedance value and a blood sedimentation corresponding value which are stored in the controller in advance, so as to obtain a blood sedimentation detection result of the blood sample to be detected, and transmits the result to the display module (1);
s3: display of detection result
And S3.1, the display screen (1-1) receives the detection result and displays the detection result on the screen.
Referring to fig. 1 to 3, the specific working process of the present invention is as follows:
injecting blood to be tested into T-shaped container (2-1), sending high-frequency current signal by controller, transmitting to electrode (2-2), the electrode (2-2) is loaded to the blood to be detected, the electrode (2-2) detects the voltage signal of the blood to be detected, and transmitting the detected voltage signal to a controller, which calculates an electrical impedance value using the formula Z = U/I, wherein Z is the electrical impedance of the blood to be detected, I is the current loaded to the blood to be detected, U is the corresponding voltage of the detected blood to be detected, the controller compares and fits the calculated electrical impedance value of the blood to be detected with the blood electrical impedance value stored in the controller and the pre-calibrated value of the corresponding relationship of the blood sedimentation to obtain the result of detecting the blood sedimentation of the blood sample to be detected, and the result is transmitted to a display module (1), and a display screen (1-1) receives the detection result and displays the detection result on the screen.
The invention relates to a blood sedimentation detection device and a detection method thereof, which utilize the bioelectrical impedance detection principle, adopt a T-shaped container as a detection container of blood to be detected, and obtain the blood sedimentation of the blood to be detected by detecting and calculating the electric impedance of the blood to be detected. The device has simple structure, simple and efficient detection and can greatly shorten the blood sedimentation detection process. The invention has wide applicability, high accuracy, simple structure, convenient miniaturization and portability, can monitor the sedimentation process in real time, and can realize the quick and efficient detection of the sedimentation.

Claims (3)

1. The blood sedimentation detection device is characterized by comprising a detection module, a control module and a display module, wherein the detection module comprises a T-shaped container and an electrode, the control module comprises a controller, and the display module comprises a shell and a display screen; the T-shaped container is used for containing blood to be detected, and the electrode is used for applying a current signal and a detection voltage signal to the blood to be detected; the controller is used for realizing signal sending, signal receiving, data processing and storage, and stores a pre-calibrated value of the corresponding relation between the blood electrical impedance value and the blood sedimentation; the display module is used for receiving and displaying the image-text signal.
2. The apparatus according to claim 1, wherein the detection module employs a T-shaped container as a detection container for blood to be detected, the electrodes are integrated in a lower vertical portion of the T-shaped container, and the T-shaped container can be taken out of the housing.
3. A method for detecting a blood sedimentation rate detecting apparatus according to claim 1, based on a bioelectrical impedance detection principle, comprising the steps of:
s1: blood test to be tested
S1.1: injecting blood to be tested into a T-shaped container;
s1.2: the controller sends out a high-frequency current signal, transmits the high-frequency current signal to the electrode and loads the high-frequency current signal to the blood to be detected through the electrode;
s1.3: the electrode detects a voltage signal of blood to be detected and transmits the detected voltage signal to the controller;
s2: calculation and processing of signal data
S2.1: calculating an electrical impedance value by using a formula Z = U/I, wherein Z is the electrical impedance of the blood to be detected, I is the current loaded to the blood to be detected, and U is the detected corresponding voltage of the blood to be detected;
s2.2: the controller compares and fits the calculated blood electrical impedance value to be detected with a blood electrical impedance value and a blood sedimentation corresponding value which are stored in the controller in advance, so as to obtain a blood sedimentation detection result of the blood sample to be detected, and transmits the result to the display module;
s3: display of detection result
And S3.1, the display screen receives the detection result and displays the detection result on the screen.
CN202011566664.6A 2020-12-25 2020-12-25 Blood sedimentation detection device and detection method thereof Active CN112557267B (en)

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