CN112557267B - Blood sedimentation detection device and detection method thereof - Google Patents
Blood sedimentation detection device and detection method thereof Download PDFInfo
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- CN112557267B CN112557267B CN202011566664.6A CN202011566664A CN112557267B CN 112557267 B CN112557267 B CN 112557267B CN 202011566664 A CN202011566664 A CN 202011566664A CN 112557267 B CN112557267 B CN 112557267B
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- blood sedimentation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/05—Investigating sedimentation of particle suspensions in blood
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention belongs to the field of blood sedimentation detection, and particularly relates to a blood sedimentation detection device and a detection method thereof. The invention solves the problems that the existing Weissella method for detecting blood sedimentation is complex, time and labor are wasted, the cost of a blood sedimentation instrument is high, the structure is large, the miniaturization is difficult to realize, portability is realized, and the inclined tube method is only applied under specific conditions and has low detection quality. The blood sedimentation detection device is composed of a detection module, a control module and a display module. The method is wide in applicability, high in accuracy, rapid and efficient, can monitor the blood sedimentation process in real time, is simple in structure, is convenient to achieve microminiaturization of blood sedimentation detection, is portable, and can be widely applied to the field of health care.
Description
Technical Field
The invention relates to the field of biomedical detection, in particular to a blood sedimentation detection device and a detection method thereof.
Background
The erythrocyte sedimentation rate refers to an index of erythrocyte sedimentation rate under certain conditions, which is simply called blood sedimentation. The erythrocyte sedimentation rate of a healthy person generally fluctuates up and down within a relatively narrow range without a large lifting change, and the erythrocyte sedimentation rate can obviously increase under the intervention of many cases. The erythrocyte sedimentation rate measurement is widely applied clinically, blood sedimentation results and clinical data are compared with each other to show that blood sedimentation detection has many applications clinically, whether a patient organism has inflammation, whether a patient lesion has activity and the like can be judged in an assisted mode, the erythrocyte sedimentation rate measurement method has important reference value for providing parameters for clinical detection, and a blood sedimentation detection method is often used clinically as a test diagnosis mode.
The Weissel method is the most classical, most traditional, most routine and reliable method for detecting blood sedimentation, and is also a routine method recommended by the International Commission on standardization of hematology, but in practical application, the process of the Weissel method is complex, manual operation is needed, only the final result of blood sedimentation at a certain moment can be detected, the specificity is poor, the application is greatly limited, and the time for observation and recording is strictly required. In recent years, people have sought a simpler and more trouble-free blood sedimentation measuring method, and are familiar with adopting a blood sedimentation instrument which can dynamically record the change of the whole blood sedimentation process, draw a curve of erythrocyte sedimentation and reflect different diseases or different orders of diseases. The inclined tube method can accelerate blood sedimentation, shorten test time, only need 15 minutes to obtain results, compared with the Weissel method, can greatly reduce waiting time of patients, and can reduce blood sampling amount by 1/3 compared with the Weissel method, but has the defects that complete contrast cannot be realized with the Weissel method, and the inclined tube method is only suitable for patients with increased blood sedimentation under specific conditions, has great limitation, and meanwhile, blood sedimentation process change has important value for judging diseases, and the inclined tube method cannot monitor blood sedimentation process change.
Disclosure of Invention
The invention aims to provide a blood sedimentation detection device and a detection method thereof, which are used for solving the problems in the prior art. The blood sedimentation detection device and the method provided by the invention are simple, convenient, quick, wide in applicability, high in accuracy and capable of monitoring the blood sedimentation process in real time, and are convenient to realize miniaturization and portability of the blood sedimentation detection device.
The above object of the present invention is achieved by the following technical solutions:
the blood sedimentation detection device comprises a detection module, a control module and a display module, wherein the detection module comprises a T-shaped container and an electrode, the control module comprises a controller, and the display module comprises a shell and a display screen; the T-shaped container is used for containing blood to be detected, and the electrode is used for applying current signals and detecting voltage signals to the blood to be detected; the controller is used for realizing signal sending, receiving, data processing and storage, and storing a preset calibration value of the corresponding relation between the blood electrical impedance value and the blood sedimentation; the display module is used for receiving and displaying image-text signals.
Further, the detection module adopts a T-shaped container as a container for detecting blood to be detected, the electrodes are integrated on the vertical part of the lower side of the T-shaped container, and the T-shaped container can be taken out from the shell.
The detection method of the blood sedimentation detection device is based on the bioelectrical impedance detection principle and comprises the following steps:
s1: blood test
S1.1: injecting blood to be tested into the T-shaped container;
s1.2: the controller sends out a high-frequency current signal, transmits the high-frequency current signal to the electrode, and loads the high-frequency current signal to blood to be tested through the electrode;
s1.3: the electrode detects a voltage signal of blood to be detected and transmits the detected voltage signal to the controller;
s2: calculation and processing of signal data
S2.1: calculating an electrical impedance value by using a formula Z=U/I, wherein Z is the electrical impedance of the blood to be measured, I is the current loaded into the blood to be measured, and U is the detected corresponding voltage of the blood to be measured;
s2.2: the controller compares and fits the calculated electrical impedance value of the blood to be measured with a pre-calibrated value of the corresponding relationship between the electrical impedance value of the blood and the blood sedimentation stored in the controller to obtain a blood sedimentation detection result of the blood sample to be measured, and transmits the result to the display module;
s3: display of detection results
And S3.1, the display screen receives the detection result and displays the detection result on the screen.
The beneficial effects of the invention are as follows: the blood sedimentation detection device and the detection method thereof are provided, wherein the T-shaped container is adopted as the container for blood detection, the impedance value obtained by the detection of the T-shaped container has a linear relation with blood sedimentation, the blood sedimentation detection process can be greatly shortened, and the simple, convenient and quick detection is realized; according to the invention, the blood sedimentation detection is carried out based on a bioelectrical impedance detection principle, a real-time impedance value is calculated by detecting a voltage and current signal in the blood sedimentation process, and then the blood sedimentation detection result is obtained and displayed by comparing and fitting with a blood impedance value and a blood sedimentation corresponding relation pre-calibration value.
Drawings
FIG. 1 is a schematic diagram of a blood sedimentation detection device;
FIG. 2 is a schematic structural view of a T-shaped container;
FIG. 3 is a schematic diagram of a blood sedimentation detection method.
In the figure:
1. a display module; secondly, a detection module; third, a control module; 1-1, displaying a screen; a t-type vessel; 2-2. Electrode.
Detailed Description
The details of the present invention and its specific embodiments are further described below with reference to the accompanying drawings.
Referring to fig. 1 to 3, a blood sedimentation detection device comprises a detection module (2), a control module (3) and a display module (1), wherein the detection module (2) comprises a T-shaped container (2-1) and an electrode (2-2), the control module (3) comprises a controller, and the display module (1) comprises a shell and a display screen (1-1); the T-shaped container (2-1) is used for containing blood to be tested, and the electrode (2-2) is used for applying current signals and detection voltage signals to the blood to be tested; the controller of the control module (3) is used for realizing signal sending, receiving, data processing and storage, and storing a preset calibration value of the corresponding relation between the blood electrical impedance value and the blood sedimentation; the display module (1) is used for receiving and displaying image-text signals.
Further, the detection module (2) adopts a T-shaped container (2-1) as a container for detecting blood to be detected, the electrode (2-2) is integrated at the vertical part of the lower side of the T-shaped container (2-1), and the T-shaped container (2-1) can be taken out from the shell.
The detection method of the blood sedimentation detection device is based on the bioelectrical impedance detection principle and comprises the following steps:
s1: blood test
S1.1: injecting blood to be tested into the T-shaped container (2-1);
s1.2: the controller sends out a high-frequency current signal, the high-frequency current signal is transmitted to the electrode (2-2), and the high-frequency current signal is loaded to blood to be tested through the electrode (2-2);
s1.3: the electrode (2-2) detects a voltage signal of blood to be detected and transmits the detected voltage signal to the controller;
s2: calculation and processing of signal data
S2.1: calculating an electrical impedance value by using a formula Z=U/I, wherein Z is the electrical impedance of the blood to be measured, I is the current loaded into the blood to be measured, and U is the detected corresponding voltage of the blood to be measured;
s2.2: the controller compares and fits the calculated electrical impedance value of the blood to be measured with a preset calibration value of the corresponding relationship between the electrical impedance value of the blood and the blood sedimentation stored in the controller to obtain a blood sedimentation detection result of the blood sample to be measured, and transmits the result to the display module (1);
s3: display of detection results
And S3.1, the display screen (1-1) receives the detection result and displays the detection result on the screen.
Referring to fig. 1 to 3, the specific working procedure of the present invention is as follows:
injecting blood to be tested into a T-shaped container (2-1), transmitting a high-frequency current signal to an electrode (2-2) by a controller, loading the high-frequency current signal to the blood to be tested through the electrode (2-2), detecting a voltage signal of the blood to be tested by the electrode (2-2), transmitting the detected voltage signal to the controller, calculating an electrical impedance value by the controller through a formula Z=U/I, wherein Z is the electrical impedance of the blood to be tested, I is the current loaded to the blood to be tested, U is the corresponding voltage of the detected blood to be tested, comparing and fitting the calculated electrical impedance value of the blood to be tested with a blood electrical impedance value and a blood sedimentation corresponding relation pre-calibrated value stored in the controller, obtaining a blood sedimentation detection result of a blood sample to be tested, transmitting the result to a display module (1), and receiving the detection result on a display screen (1-1) and displaying the detection result on the screen.
The invention relates to a blood sedimentation detection device and a detection method thereof, which utilize a bioelectrical impedance detection principle, adopt a T-shaped container as a container for detecting blood to be detected, and obtain the blood sedimentation of the blood to be detected by detecting and calculating the impedance of the blood to be detected. The device has simple structure, simple and efficient detection and can greatly shorten the blood sedimentation detection process. The invention has wide applicability, high accuracy, real-time monitoring of the blood sedimentation process, simple structure, contribution to microminiaturization of blood sedimentation detection, portability and realization of rapid and high-efficiency detection of blood sedimentation.
Claims (2)
1. The blood sedimentation detection device is characterized by comprising a detection module, a control module and a display module, wherein the detection module comprises a T-shaped container and an electrode, the control module comprises a controller, and the display module comprises a shell and a display screen; the T-shaped container is used for containing blood to be detected, and the electrode is used for applying a current signal and a detection voltage signal to the blood to be detected; the controller is used for realizing signal sending and receiving and data processing and storage, and storing a preset calibration value of the corresponding relation between the blood electrical impedance value and the blood sedimentation; the display module is used for receiving and displaying image-text signals; the detection module adopts a T-shaped container as a container for detecting blood to be detected, the electrode is integrated at the vertical part of the narrow section of the lower side of the T-shaped container, and the T-shaped container can be taken out from the shell; the blood sedimentation detection device is used for detecting blood sedimentation based on a bioelectrical impedance detection principle, a real-time impedance value is calculated by detecting a voltage and current signal in the blood sedimentation process, and then a blood sedimentation detection result is obtained and displayed by comparing and fitting the real-time impedance value with a blood impedance value and a blood sedimentation corresponding relation pre-calibration value.
2. A method of detecting a blood sedimentation detection device as claimed in claim 1, characterized by the fact that it is based on bioelectrical impedance detection principle, comprising the steps of:
s1: blood test
S1.1: injecting blood to be tested into the T-shaped container;
s1.2: the controller sends out a high-frequency current signal, transmits the high-frequency current signal to the electrode, and loads the high-frequency current signal to blood to be tested through the electrode;
s1.3: the electrode detects a voltage signal of blood to be detected and transmits the detected voltage signal to the controller;
s2: calculation and processing of signal data
S2.1: calculating the electrical impedance value of the blood to be measured by using a formula Z=U/I, wherein Z is the electrical impedance value of the blood to be measured, I is the current loaded into the blood to be measured, and U is the detected corresponding voltage of the blood to be measured;
s2.2: the controller compares and fits the calculated electrical impedance value of the blood to be measured with a preset calibration value of the corresponding relationship between the electrical impedance value of the blood and the blood sedimentation stored in the controller to obtain a blood sedimentation detection result of the blood sample to be measured, and transmits the detection result to the display module;
s3: display of detection results
And S3.1, the display screen receives the detection result and displays the detection result on the screen.
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Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1366371A (en) * | 1971-08-25 | 1974-09-11 | Standaart A W | Automatic sedimentation rate recorder |
| CN86105076A (en) * | 1985-09-06 | 1987-03-04 | 株式会社尼肖 | Blood sampling and measurement erythrocyte sedimentation rate device |
| US4648265A (en) * | 1984-06-13 | 1987-03-10 | Walter Sarstedt Kunststoff-Spritzgusswerk | Blood sedimentation apparatus |
| US5779983A (en) * | 1995-07-21 | 1998-07-14 | Becton, Dickinson & Company | Test tube for determining the erythrocyte sedimentation rate and a surfactant for use therein |
| US5914272A (en) * | 1996-06-19 | 1999-06-22 | Becton Dickinson And Company | Test method for determining the erythrocyte sedimentation rate and a surfactant for use therein |
| JP2001245874A (en) * | 2000-03-03 | 2001-09-11 | Sefa Technology Kk | Blood collecting tube for measuring red corpuscle sedimentation speed, blood collecting tube holder, protector for carrying blood collecting tube, and method and device for measuring red corpuscle sedimentation speed |
| JP2005077148A (en) * | 2003-08-28 | 2005-03-24 | Japan Clinical Laboratories Inc | Blood examination method and device |
| KR20100104927A (en) * | 2009-03-19 | 2010-09-29 | 주식회사 한비메디칼 | Sample storage container, sample storage and inspection preparation system and the storage and inspection preparation method threrof |
| CN202330225U (en) * | 2011-11-27 | 2012-07-11 | 孙兆海 | Novel erythrocyte sedimentation rate measurement tube |
| CN203929577U (en) * | 2014-05-23 | 2014-11-05 | 段艳丽 | A kind of erythrocyte sedimentation rate detector tube fast |
| CN204044031U (en) * | 2013-12-19 | 2014-12-24 | 华北石油管理局总医院 | A kind of erythrocyte sedimentation rate testing stand automatically |
| CN109164253A (en) * | 2018-10-26 | 2019-01-08 | 浙江师范大学 | A kind of tuning fork resonant mode blood platelet shrinks force measuring device and method |
| CN109752295A (en) * | 2017-11-03 | 2019-05-14 | 苏州泰寿健康科技有限公司 | A kind of quick esr measurement method and its measuring device |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000329779A (en) * | 1999-05-19 | 2000-11-30 | Sefa Technology Kk | Sedimentation speed measuring method and its device |
| JP2004125655A (en) * | 2002-10-03 | 2004-04-22 | Sefa Technology Kk | Apparatus for determining blood sedimentation rate |
| US7069771B1 (en) * | 2005-02-09 | 2006-07-04 | Roger Yates Anderson | Partitioning sediment trap |
| CN2800264Y (en) * | 2005-04-08 | 2006-07-26 | 姜世民 | Automatic erythrocyte sedimentation rate measurer |
| CN101936872A (en) * | 2010-08-23 | 2011-01-05 | 张国建 | Site test instrument of sand content in well water |
| DE102011050550A1 (en) * | 2011-05-20 | 2012-11-22 | Wolfgang Göhde | Method and apparatus for quantifying subgroups from a mixed population of cells |
| KR101745478B1 (en) * | 2015-11-12 | 2017-06-09 | 광주과학기술원 | An erythrocyte sedimentation rate evalution apparatus and method |
| CN105675460A (en) * | 2016-03-08 | 2016-06-15 | 重庆理工大学 | Method for accelerating blood sedimentation by virtue of voltage |
| CN106525672A (en) * | 2016-12-29 | 2017-03-22 | 山东朗伯光谱设备有限公司 | Method and device for acquiring cell agglutination graph |
| CN110907499A (en) * | 2019-04-08 | 2020-03-24 | 浙江师范大学 | Portable thrombus detection device based on broadband bioelectrical impedance |
-
2020
- 2020-12-25 CN CN202011566664.6A patent/CN112557267B/en active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1366371A (en) * | 1971-08-25 | 1974-09-11 | Standaart A W | Automatic sedimentation rate recorder |
| US4648265A (en) * | 1984-06-13 | 1987-03-10 | Walter Sarstedt Kunststoff-Spritzgusswerk | Blood sedimentation apparatus |
| CN86105076A (en) * | 1985-09-06 | 1987-03-04 | 株式会社尼肖 | Blood sampling and measurement erythrocyte sedimentation rate device |
| US5779983A (en) * | 1995-07-21 | 1998-07-14 | Becton, Dickinson & Company | Test tube for determining the erythrocyte sedimentation rate and a surfactant for use therein |
| US5914272A (en) * | 1996-06-19 | 1999-06-22 | Becton Dickinson And Company | Test method for determining the erythrocyte sedimentation rate and a surfactant for use therein |
| JP2001245874A (en) * | 2000-03-03 | 2001-09-11 | Sefa Technology Kk | Blood collecting tube for measuring red corpuscle sedimentation speed, blood collecting tube holder, protector for carrying blood collecting tube, and method and device for measuring red corpuscle sedimentation speed |
| JP2005077148A (en) * | 2003-08-28 | 2005-03-24 | Japan Clinical Laboratories Inc | Blood examination method and device |
| KR20100104927A (en) * | 2009-03-19 | 2010-09-29 | 주식회사 한비메디칼 | Sample storage container, sample storage and inspection preparation system and the storage and inspection preparation method threrof |
| CN202330225U (en) * | 2011-11-27 | 2012-07-11 | 孙兆海 | Novel erythrocyte sedimentation rate measurement tube |
| CN204044031U (en) * | 2013-12-19 | 2014-12-24 | 华北石油管理局总医院 | A kind of erythrocyte sedimentation rate testing stand automatically |
| CN203929577U (en) * | 2014-05-23 | 2014-11-05 | 段艳丽 | A kind of erythrocyte sedimentation rate detector tube fast |
| CN109752295A (en) * | 2017-11-03 | 2019-05-14 | 苏州泰寿健康科技有限公司 | A kind of quick esr measurement method and its measuring device |
| CN109164253A (en) * | 2018-10-26 | 2019-01-08 | 浙江师范大学 | A kind of tuning fork resonant mode blood platelet shrinks force measuring device and method |
Non-Patent Citations (5)
| Title |
|---|
| A new bioelectrical impedance method for measurement of the erythrocyte sedimentation rate;Kichul Cha 等;《Physiological Measurement》;第15卷(第4期);第499-508页 * |
| Red blood cells aggregability measurement of coagulating blood in extracorporeal circulation system with multiple-frequency electrical impedance spectroscopy;Jianping Li 等;《Biosensors & Bioelectronics》;第112卷;第79-85页 * |
| 抗瓜氨酸化蛋白/肽抗体及类风湿因子在类风湿关节炎早期诊断中的应用;王毅 等;《天津医药》;第40卷(第3期);第212-214页 * |
| 电阻法测量红细胞流变特性的理论探讨;文宗曜 等;《生物物理学报》;第8卷(第1期);第158-164页 * |
| 血液阻抗的测量与研究;张芳涛 等;《医疗设备信息》;第18卷(第10期);第13-14页 * |
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