KR101431011B1 - Dielectric resonator using electromagnetic wave and cavity resonance, apparatus and method for sensing glucose thereof - Google Patents

Abstract

Disclosed is a dielectric resonator using electromagnetic waves and cavity resonance, and a blood glucose measurement technique using the dielectric resonator. A blood glucose measurement device according to an embodiment includes a source part for generating electromagnetic field energy, a sensor part for receiving electromagnetic field energy and irradiating the object to be measured, a sensor part for detecting a radio wave reflected from the object to be measured and a source part, And a processing unit for determining a frequency and calculating a change in the blood sugar amount of the measured object from a change in the resonance frequency and the reflectance of the radio wave detected through the sensor unit, wherein the outside of the sensor unit is a metal and the inside is formed of a cavity structure filled with air And a dielectric resonator that has a hole formed in the center inside thereof and interacts with the measured object by inserting the measured object into the center.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dielectric resonator using electromagnetic wave and cavity resonance,

The present invention relates to an apparatus and a method for measuring blood glucose, and more particularly, to an apparatus and method for measuring blood glucose using an electromagnetic (EM) sensor using a non-invasive method that does not injure the human body, A glucose sensor for measuring blood glucose of a measurement object, and an apparatus and a method for measuring blood glucose.

Diabetes mellitus is a type of metabolic disease that lacks insulin secretion or does not function normally. It is characterized by hyperglycemia in which the concentration of glucose in the blood rises. Hyperglycemia causes various symptoms and signs and excretes glucose from the urine . Many diseases, including diabetes, can detect abnormalities in health through blood sugar, so many of the medical diagnoses often involve blood glucose measurement. In particular, such a blood glucose meter is required to continuously monitor blood glucose changes in patients, and non-patent documents cited below provide technical means for such continuous blood glucose monitoring.

On the other hand, a conventional blood glucose measuring device currently used is a blood glucose measuring device for measuring blood glucose by collecting blood from a patient. Among these, the blood glucose measuring device is a device that can easily purchase test strips from a pharmacy and can measure blood glucose through blood collection. It is a device that can manage diabetes by checking blood glucose level easily at home.

However, the blood glucose meter needs to be collected every time blood glucose measurement, additional disinfection to prevent infection of the blood collection site, and pain and hygiene problems are required because the needle must be used for blood collection. Recently, a diabetic phone capable of measuring blood sugar using a mobile phone has been introduced regardless of the place. However, the configuration and principle of the conventional blood glucose meter are not so different from those of the conventional blood glucose meter in that blood collection must be accompanied.

 Design and Implementation of System for Improving Treatment of Diabetic Patients through Continuous Monitoring of Blood Glucose, Jang Hyun Jang, Yeungnam University, 2011.

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above-mentioned problems occurring in the prior art, And to overcome the defects and errors of noise, irregular noise, and measurement heterogeneity due to the change of measurement position of the part to be measured of the patient.

According to an aspect of the present invention, there is provided a blood glucose measurement device including: a source for generating electromagnetic energy of a predetermined frequency; A sensor unit for receiving electromagnetic field energy generated from the source unit, irradiating the object to be measured with the electromagnetic field energy, and detecting a radio wave reflected from the object to be measured; And a processing unit for controlling the source unit to determine a resonance frequency of the sensor unit and calculating a change in blood sugar amount of the measured object from a change in resonance frequency and reflectance of the radio wave detected through the sensor unit, A cavity is formed in the outer side of the body and the inside of the cavity is filled with air and a hole is formed in the center of the cavity to insert the object to be measured in the center of the cavity, And has an interacting dielectric resonator.

In the blood glucose measurement apparatus according to an embodiment, the hole formed in the center of the sensor unit is formed in a cylindrical shape, thereby fixing the measured object such that the measured object is positioned at the center of the dielectric resonator.

In the blood glucose measurement apparatus according to an embodiment of the present invention, the sensor unit may include an input / output terminal formed with a coupling of a single port, thereby reducing a radiation loss of the electromagnetic energy to the dielectric resonator .

In the blood glucose measurement apparatus according to an embodiment of the present invention, the sensor unit reflects a reflection coefficient from a measured object using a dielectric permittivity according to a reflection coefficient and a frequency change according to a glucose concentration in the measured object And detects radio waves.

In the blood glucose measurement apparatus according to an embodiment, the processing unit may compute a visual data on the quantitative change of the blood sugar amount of the measured object by comparing the change of the resonance frequency and the reflectance of the radio wave detected through the sensor unit with a previously stored database And a display unit for displaying the generated visual data.

In the blood glucose measurement apparatus according to an embodiment, the sensor unit inspects the measured object non-invasively.

According to another aspect of the present invention, there is provided an apparatus for measuring glucose concentration by a sensor according to another embodiment of the present invention, wherein the sensor forms a cavity structure in which an outer portion is made of metal and an inner portion is filled with air, A dielectric resonator in which a hole is formed in a center inside and a measured object is inserted in the center; And an input / output terminal formed with a coupling of a single port, wherein an electromagnetic field energy is irradiated to the object to be measured through the dielectric resonator, and a result of interaction with the object to be measured, The change of the resonance frequency and the reflectance is detected.

In the apparatus for measuring the concentration of glucose according to another embodiment, the hole formed in the center of the sensor is formed in a cylindrical shape so that the object to be measured is fixed to the center of the dielectric resonator And maintains the reproducibility of the sensor above the threshold value.

In the apparatus for measuring the concentration of glucose according to another embodiment, the dielectric resonator of the cavity structure may be composed of any one metal of aluminum (Al), copper (Cu), or stainless steel (SUS) The surface of any one of the above metals may be coated with gold (Au).

According to an aspect of the present invention, there is provided a blood glucose measurement method comprising: inserting an object to be measured into a hole formed in a center of a sensor having a dielectric resonator interacting with an object to be measured; Receiving electromagnetic field energy of a predetermined frequency generated from a source; The sensor irradiating the object to be measured with the input electromagnetic field energy; Detecting a radio wave reflected from the measured object by the sensor; And calculating a change in blood glucose level of the measured object from a change in the resonance frequency and the reflectance of the detected radio wave, wherein the sensor forms a cavity structure in which the outside is metal and the inside is filled with air, The holes formed in the center of the sensor are formed in a cylindrical shape to hold the measured object so that the measured object is positioned at the center of the dielectric resonator so that the reproducibility of the sensor is maintained above the threshold.

The method of measuring blood sugar according to an embodiment of the present invention includes the steps of generating blood glucose level information according to a resonance frequency and a reflectance of a radio wave and storing the blood glucose level information in a database in advance; And displaying visual data on a change in the blood sugar level of the object to be measured through a display device, wherein the step of calculating the change in the blood glucose level comprises: measuring a resonance frequency and a reflectance Of the measured object is compared with a previously stored database to generate visual data on the quantitative change of the blood sugar amount of the measured object.

Meanwhile, a computer-readable recording medium on which a program for executing the above-described blood glucose measurement method on a computer is recorded is provided.

The present invention can measure blood glucose without irradiating the patient with blood by irradiating the radio waves non-invasively and detecting changes in the resonance frequency and reflectance of the radio waves reflected from the object to be measured. As a result, The blood glucose of the object to be measured is fixed to the hole formed at the center inside of the sensor part so that the change of the measurement position is minimized by directly reacting with the center of the resonator and by using the resonator of the cavity structure, Accuracy, and measurement speed, as well as quality stability and frequency stability for temperature coefficient. In addition, the present invention can provide blood glucose measurement means that can monitor blood glucose change of a human body in real time over time by detecting blood glucose of a measured object using radio waves.

1 is a block diagram showing a blood glucose measurement apparatus according to an embodiment of the present invention.
2 is a perspective view illustrating a sensor unit of a blood glucose measurement apparatus according to an embodiment of the present invention.
FIGS. 3A and 3B are views showing the internal structure of a perspective view and a front view of the sensor of the blood glucose measurement apparatus of FIG. 2, respectively.
4 is a flowchart illustrating a blood glucose measurement method according to an embodiment of the present invention.
5 is a graph illustrating changes in resonance characteristics according to resonance frequencies in a dielectric resonator of a blood glucose measurement apparatus according to an embodiment of the present invention.
6 is a graph illustrating a form of a magnetic field distribution measured using the blood glucose measurement apparatus according to an embodiment of the present invention.

Before describing the embodiments of the present invention, a basic idea that the embodiments are commonly employed will be presented. As described above, in order to solve the problems (pain, unsanitary) of a conventional blood glucose measuring device, the embodiments of the present invention have focused on a method of measuring blood glucose through a non-invasive method.

For this non-invasive blood glucose measurement, the following examples utilize the property of changing the dielectric property through glucose-induced from the blood in human tissue. In addition, the following embodiments are intended to measure the blood glucose of an object to be measured using electromagnetic (EM) without direct contact with blood in the object to be measured for non-invasive blood glucose measurement. Such electromagnetic media may include radio waves, in particular microwaves. Embodiments of the present invention include a microwave sensor that can be used to non-invasively determine the glucose concentration in a measured object and to monitor the change in real time, .

According to the method of measuring glucose response using a single probe that emits microwaves in accordance with a near-field principle, many errors are caused according to measurement positions, irregular noise flows in accordance with changes in measurement positions, Have been found to have a negative impact on the sensitivity and stability of blood glucose measurement.

Therefore, embodiments of the present invention to be described below propose an apparatus and method for more accurately detecting glucose concentration and blood sugar by utilizing a dielectric resonator having a hole formed inside the center of a sensor unit, rather than a single probe provided outside do. In addition, such a dielectric resonator is not a general dielectric filled with a dielectric material as a whole, but a resonator having a cavity structure in which the outside is formed of a metal and the inside is filled with air. By adopting such a cavity structure, the resonator sensor implemented by embodiments of the present invention has an excellent quality factor (Q), and the frequency stability against temperature can be improved. Here, the quality factor is a major factor of the design of a high-quality filter, and quantitatively shows the sharpness of the resonance peak as shown in the following equation (1).

In Equation (1), Q _L is a loaded Q that indicates how resonant the peak is, Q _U represents a loss-compensated unloaded Q. F _C is a resonance frequency, and F _L and F _H represent frequencies above and below 3dB B / W from the resonance frequency, respectively.

In the following, embodiments of the present invention will be described in more detail with reference to the related drawings. In the drawings, like reference numerals refer to like elements.

FIG. 1 is a block diagram showing a blood glucose measurement apparatus according to an embodiment of the present invention, in which a measured object 0 is shown along with a blood glucose measurement apparatus 1. The blood glucose measurement apparatus 1 mainly includes a source section 10, a sensor section 20, a processing section 30 and a database 35 accompanied therewith. In addition, a display unit 40 for displaying information generated through the processing unit 30 may be utilized.

The source unit 10 generates electromagnetic energy corresponding to a certain range of frequencies. Various energy sources capable of reacting with glucose in the object of measurement 0 can be used as the electromagnetic energy. However, in the present embodiment, a method using radio waves is exemplified. In particular, interaction with the object to be measured is considered And a set microwave can be utilized. The electromagnetic energy is controlled by the processing unit 30 to be described later to generate a frequency level suitable for the object to be measured.

The sensor unit 20 receives the electromagnetic field energy generated from the source unit 10, irradiates the object to be measured, and detects a radio wave reflected from the object to be measured. Particularly, in the embodiments of the present invention, the sensor unit 20 includes a dielectric resonator having a hole formed in the center thereof and directly interacting with the object to be measured (0). That is, in the dielectric resonator according to the embodiments of the present invention, a sample (blood sugar) of an object to be measured is directly placed on a central portion of a dielectric resonator instead of a separate external probe, the electromagnetic energy is directly irradiated, do.

Conventionally, in the blood glucose measurement method using the external probe, since the glucose concentration is not directly measured at a location where the electromagnetic energy is concentrated, but the measurement is performed through a probe electrically connected to the outside, An error may occur depending on the position, and defects such as noise, irregular noise, and measurement inhomogeneity due to changes in the measurement position have occurred.

In contrast, in the sensor unit 20 commonly adopted in the embodiments of the present invention, the object to be measured and the dielectric resonator can directly react through the hole formed in the center. That is, it is preferable that the holes formed in the center of the sensor unit 20 are formed in such a form that the object to be measured can be fixed so that the measured object is positioned at the center of the dielectric resonator. For this purpose, it is preferable that the hole formed in the center of the sensor unit 20 is formed in a cylinder shape, but the practical structure of such a hole is not limited to the shape of the hole formed by the person skilled in the art It can be flexibly designed and implemented within the scope of the technical idea of the invention.

Therefore, according to the above-described configuration, the measurement result of blood glucose changes unexpectedly according to the position of the object to be measured which is in contact with the external probe, and the conventional problem that irregular noise and measurement uniformity appear in the measurement result can be solved. There is no particular limitation on the type of the dielectric for implementing the dielectric resonator, and a suitable dielectric can be selected by those skilled in the art.

The sensor unit 20 has a cavity structure in which the outside is made of metal and the inside is filled with air so that the quality factor and the temperature stability are improved as compared with a conventional dielectric resonator in which the dielectric is filled all over the inside of the resonator. , Resulting in improved resolution and precision.

The sensor unit 20 is a means for contacting the object to be measured (a specific part of the human body for measuring blood sugar, for example, a finger or the like). The blood glucose measurement apparatus 1 according to the embodiment of the present invention ) Measures the glucose level of the patient while reacting with the glucose solution in the object to be measured (that is, the blood inside the human body) by transmitting the electromagnetic field energy generated from the source unit 10 to the dielectric resonator of the sensor unit 20 . More specifically, the sensor unit 20 detects a radio wave reflected from the object to be measured 0 using a reflection coefficient according to the glucose concentration in the object to be measured 0 and a dielectric constant according to the change in frequency. At this time, this dielectric constant is determined by the combination of the electric energy in the measured object (0) and the loss of electric energy.

The processing unit 30 controls the source unit 10 to determine the resonance frequency of the sensor unit 20 and detects the resonance frequency of the object of measurement 0 from the change of the resonance frequency and reflectance of the radio wave detected through the sensor unit 20. [ And calculates a change in blood glucose level. The processor 30 can use the microwave signal analysis of glucose to measure the glucose concentration from a non-direct measurement of the dielectric constant or from a direct measurement of the reflection coefficient of the microwave. A parameter utilized in the processing section 30 is a dielectric permittivity which is one of the main material characteristics of the medium.

In summary, the sensor unit 20 measures the change in the reflection coefficient of the resonator that contacts the object to be measured 0 at a resonance frequency of a certain range to determine a change in glucose concentration. It has been confirmed that the reflection coefficient changes due to the electromagnetic interaction between the microwave sensor unit 20 and the object to be measured 0, and this change is directly related to the glucose concentration change. Then, the processing unit 30 can determine the glucose concentration in real time through the change of the microwave reflection coefficient measured through the sensor unit 20. [

The processing unit 30 compares the change of the resonance frequency and reflectance of the radio wave detected through the sensor unit 20 with the previously stored database 35 to obtain a visual change of the quantitative change of the blood sugar amount of the measured object 0 Data can be generated. In addition, the blood glucose measurement device 1 can display visual data generated in this way through the display unit 40. Such a display unit 40 may be selectively included according to an embodiment in which the embodiment of the present invention is implemented.

2 is a perspective view illustrating a sensor unit of a blood glucose measurement apparatus according to an embodiment of the present invention. As described briefly above, in the case of the conventional external probe type sensor, the probe is exposed to the outside from the dielectric resonator, and blood glucose measurement is performed by directly contacting the object to be measured with the probe exposed to the outside. However, as shown in FIG. 2, the blood glucose measurement apparatus proposed by the embodiments of the present invention is characterized in that a hole 25 is formed in the blood glucose measurement device 1 without an external probe, Object (0) is inserted to perform blood glucose measurement. It is a matter of course that a sensor (not shown) having a dielectric resonator is provided in the blood glucose measurement device 1. [

Particularly, the holes 25 formed in the blood glucose measurement device 1 of FIG. 2 not only allow the object to be measured 0 to be directly positioned at the center of the dielectric resonator so as to interact with each other, So that the measurement position is not changed. With this configuration, irregular noise and measurement inhomogeneity can be prevented from occurring without changing the measurement position of the measured object 0 even in a plurality of measurement processes.

As described above, in the embodiments of the present invention, it is referred to as reproducibility in which consistent measurement results can be ensured. Reproducibility means the same measurement object as the measurer, the apparatus, the measurement site, Refers to the property or degree by which the individual measurements coincide when any one of them is measured under different conditions. Therefore, the position of the hole 25 and the dielectric resonator realized through the embodiments of the present invention can be reproduced with a certain level (for example, can be kept above a preset threshold value) through a plurality of experiments and measurement results It is desirable to be implemented so that the above-described structure can be maintained. That is, this reproducibility depends on how consistently the blood glucose measurement results for the object to be measured (0) can be obtained.

In addition, the blood glucose measurement apparatus 1 of FIG. 2 has an input / output terminal 27 formed with a coupling of a single port, thereby reducing the radiation loss of the electromagnetic energy to the dielectric resonator . The input / output terminals 27 may be implemented in various forms according to the characteristics and specifications of the medium supplying the input / output signals. However, it is preferable to implement the input / output terminals 27 as a single port as illustrated in FIG.

FIGS. 3A and 3B are views showing the internal structure of a perspective view and a front view of the sensor of the blood glucose measurement apparatus of FIG. 2, respectively. As described above with reference to FIG. 2, the blood glucose measurement device includes a sensor including the dielectric resonator 23, and a hole is formed in the center of the upper end of the blood glucose measurement device to insert the measured object. At this time, since the electromagnetic field formed from the dielectric resonator 23 is uniformly formed around the dielectric resonator 23, more accurate blood glucose measurement is possible if the object to be measured can be accurately positioned at the center of the dielectric resonator 23 . 3A and 3B, according to the embodiments of the present invention, the object to be measured is inserted and fixed at the center of the dielectric resonator 23 to ensure the reproducibility of blood glucose measurement, and irregular Noise and measurement inhomogeneity can be prevented.

In addition, the sensor of the blood glucose measurement device exemplified in Figs. 3A and 3B adopts a cavity structure in which the outside is formed of metal and the inside is filled with air. Here, the outside of the sensor may be made of any one of aluminum (Al), copper (Cu), and stainless steel (SUS), or the surface of any one of the above metals may be coated with gold (Au). Considering the production cost from a practical point of view, it has been confirmed that a cavity resonator formed of aluminum in the outside can guarantee a low relative dielectric constant, a high quality factor and a temperature stability.

3A and 3B, the sensor of the blood glucose measurement apparatus includes an input / output terminal 27 having a single port coupling formed therein, so that the electromagnetic field energy for the dielectric resonator 23 It is possible to reduce the radiation loss of the antenna.

In the meantime, the non-invasive sensor according to the present embodiment includes a dielectric resonator having a hole formed inside the center of the sensor and directly interacting with the object to be measured, thereby irradiating microwave to the object to be measured through the dielectric resonator, As a result of the interaction with the object to be measured, a change in the resonance frequency and reflectance of the wave reflected from the object to be measured is detected. For this purpose, the non-invasive sensor uses the dielectric constant according to the reflection coefficient and the frequency change according to the glucose concentration in the measured object.

Now, let's look at the implementation principle and the theory of this embodiment in more detail.

The measurement of blood glucose through the dielectric resonator commonly adopted in the embodiments of the present invention is dependent on the reflection coefficient and the frequency change depending on the glucose concentration. The operating principles of these sensors are based on a change in the reflection coefficient S ₁₁ and the resonance frequency f ₀ parameter from a change in the characteristics of the measured object, such as dielectric permittivity and magnetic permeability, Based.

First, the susceptibility depends on the change in magnetic energy in the material. In general, most of the diamagnetic or paramagnetic materials are not affected by external magnetic fields because they do not have strong magnetic field properties. On the other hand, ferromagnetic material, which is a nonlinear medium, is strongly influenced by external magnetic field change. However, most biological samples are hardly affected by external magnetic fields. Thus, the susceptibility, which is one of the characteristics of such a measured object in terms of embodiments of the present invention with respect to the glucose level in the human body, can be ignored.

Next, let's look at one of the other important characteristic parameters of the measured object, the dielectric constant. The dielectric constant has a complex-form characteristic as shown in the following Equation 2, depending on the material.

는 실수부로서 물질 내의 전기 에너지에 의해 결정된다. 전자기(EM) 신호가 물질을 통과할 때, 허수부

는 에너지 손실

에 의해 결정된다. 글루코스 솔루션에서 덱스트로오스(dextrose)의 유전상수는 몰농도 증가분 δ에 의해 이상의 수학식 2로부터 다음의 수학식 3과 같이 표현될 수 있다.In Equation 2,

Is determined by electrical energy in the material as a real part. When an electromagnetic (EM) signal passes through the material,

Energy loss

. In the glucose solution, the dielectric constant of dextrose can be expressed by the molar concentration increment [delta] from the above equation (2) as the following equation (3).

는 37℃에서

(mg/dl)^-1과

(mg/dl)^-1에 의한 글루코스 농도의 유니트(unit) 증가분이고,

는 증류수(de-ionized water, DI water)의 유전상수다. 이 때, 증류수의 실수부와 허수부의 복소수 유전상수는 다음의 수학식 4와 같이 표현될 수 있다. In Equation 3, the constant c is the concentration of glucose,

Lt; / RTI >

(mg / dl) ^-1 and

(mg / dl) < ^-1 >

Is the dielectric constant of de-ionized water (DI water). At this time, the complex dielectric constant of the real part and the imaginary part of the distilled water can be expressed by the following equation (4).

In Equation (4) _,? Is the dielectric constant in the high frequency region,? _S is the dielectric constant in the low frequency region, and? Represents the characteristic relaxation time of the material.

The dielectric constant, which is an important characteristic parameter of the object to be measured, can be determined as described above. The change in the dielectric constant is represented by a change in the characteristics of the object to be measured, and the change in the reflection coefficient S ₁₁ and the resonance frequency f ₀ Can be derived. The reason why the waveform pattern of the microwave propagating through the dielectric resonator changes due to the interaction with the object to be measured is that the dielectric constant changes according to the equivalent contained in the blood of the object to be measured, thereby changing the reflection coefficient S ₁₁ .

The change of the reflection coefficient S ₁₁ according to the amount of blood sugar shows that the center frequency and the peak value of the reflection coefficient vary according to the blood sugar amount. In the blood glucose measurement apparatus according to the embodiment of the present invention, the microwave having a constant bandwidth is irradiated to the object to be measured by the sensor, so that the frequency of the microwave detected after the interaction is shifted. That is, the waveform change pattern of the microwave is measured through the sensor, and the processing unit calculates data on the blood sugar amount from the measured value. At this time, the blood sugar amount can be calculated from the database of the relationship between the measured waveform change pattern and the waveform change pattern and the blood sugar amount prepared in advance. The measurement of the waveform change pattern can be performed by, for example, measuring the area shifted by the graph on the graph expressed by the frequency versus amplitude of the microwave, and measuring the power change of the microwave from the measured area. .

FIG. 4 is a flowchart illustrating a blood glucose measurement method according to an embodiment of the present invention, including steps corresponding to the blood glucose measurement apparatus of FIG. 1. For convenience of description, only the outline of each step will be described with reference to the correspondence with the configuration of FIG. 1, and a detailed description thereof will be omitted.

In step 410, the object to be measured is inserted into a hole formed in the center of a sensor having a dielectric resonator having a cavity structure interacting with the object to be measured.

In step 420, the sensor receives the electromagnetic field energy of a certain range of frequencies generated from the source.

In step 430, the sensor irradiates the object to be measured with the electromagnetic field energy input through step 420 and detects a wave reflected from the object to be measured. As described above, such a sensor is manufactured without a separate external single probe, and has a dielectric resonator having a cavity structure in which the outside is metal and the inside is filled with air. The hole in the center inside is formed into a cylindrical shape, By fixing the object to be measured so that the object is located at the center of the dielectric resonator, the reproducibility of the sensor is maintained above the threshold value.

In step 440, the change of the blood sugar amount of the measured object is calculated from the change of the resonance frequency and the reflectance of the radio wave detected through step 440.

According to the embodiments of the present invention described above, it is possible to measure blood glucose without taking blood from a patient, and as a result, inconvenience of pain and unsanitary can be solved. In addition, by positioning the object to be measured directly at the center of the dielectric resonator through a hole formed in the center of the sensor without a single external probe, sensitivity and accuracy of blood glucose measurement can be improved. In addition, Coefficient and improved temperature stability.

Meanwhile, the blood glucose measurement method according to another embodiment of the present invention may further include the following additional steps.

In step 450, visual data on the change in the blood glucose level of the measured object is displayed through the display device. For this purpose, in calculating the change of the blood glucose level in step 440, it is possible to generate visual data on the quantitative change of the blood glucose level of the measured object by comparing the change of the resonance frequency and the reflectance of the radio wave detected through the sensor with the database have. It is needless to say that it is necessary to generate the blood sugar amount information according to the resonance frequency and the reflectance of the radio wave before these processes are performed and to store the information in advance in the database.

According to another embodiment of the present invention, it is possible to provide blood glucose measurement means capable of monitoring blood glucose change of a human body in real time over time.

FIG. 5 is a graph illustrating changes in resonance characteristics according to resonance frequencies in a dielectric resonator of a blood glucose measurement apparatus according to an embodiment of the present invention. FIG. 5 shows changes in resonance characteristics at specific resonance frequencies according to respective glucose concentrations. The rightmost graph in FIG. 5 represents the glucose concentration of the DI water and is shown at the glucose concentration of 92 mg / dl, 192 mg / dl, 292 mg / dl, 392 mg / dl and 492 mg / . FIG. The left axis of the internal view of FIG. 5 represents the resonance frequency change according to the glucose concentration change of the dielectric resonator, and the right axis represents the change of the reflection coefficient.

5, it can be seen that the microwave reflection coefficient according to the resonance frequency of the dielectric resonator changes greatly according to the blood sugar, that is, the glucose concentration of the object to be measured. Therefore, the embodiments of the present invention proposed above can acquire the basic data of blood glucose measurement from the reflection coefficient of the microwave reflected from the measured object based on the experimental value.

FIG. 6 is a graph illustrating the formation of a magnetic field distribution measured using a blood glucose measurement apparatus according to an embodiment of the present invention. The glucose concentration in a sample is represented by a dielectric constant. In FIG. 6, red and yellow indicate that the field image is stronger than the surrounding area. Referring to FIG. 6, it can be seen that as the dielectric constant (sugar content) is finely increased, the red part and the yellow part in the image are expanded and the color is enhanced.

Particularly, in the embodiments of the present invention, the object to be measured is fixed through a hole formed in the center of the sensor using a dielectric resonator having a cavity structure, and blood is directly reacted to the central part of the dielectric resonator or the inside of the human body It can be seen that the reproducibility of a certain level or more can be ensured. As a result of the experiment, it is confirmed that the image resolution of the magnetic field distribution is improved by the improvement of the resolution as compared with the conventional conventional dielectric resonator, there was.

According to the embodiments of the present invention as described above, the object to be measured is fixed to the hole formed in the center of the sensor part of the blood glucose measurement device so that the blood glucose reacts directly with the center of the resonator, Sensitivity, accuracy, and measurement speed can be improved. Particularly, by utilizing a resonator having a cavity structure, it has an advantage that it can improve the frequency stability against temperature while ensuring a quality factor as compared with a conventional dielectric resonator. Further, blood glucose can be directly and accurately measured by reacting with blood, and it is possible to obtain a medical diagnosis from a remote physician by measuring changes in blood glucose change in real time.

Meanwhile, the resonator sensor of the blood glucose measurement apparatus according to these embodiments can be replaced by a resonator pattern suitable for the use by a person having ordinary skill in the art to which the present invention belongs. And the structure can be changed and designed, thereby improving the sensitivity of the blood sugar measurement. The internal insertion type dielectric resonator sensor using the electromagnetic wave can be designed by selecting a frequency in the MHz range from the GHz range while maintaining stable characteristics with respect to the external probe type sensor. In addition, it is possible to improve the noise-to-signal characteristic and the minimum glucose detection ability, and to make an experimental or diagnostic error that may occur due to a defect such as noise, irregular noise, measurement inhomogeneity, Can be solved.

Further, in order to control the above-described blood glucose measurement apparatus, another embodiment of the present invention can be implemented as a computer-readable code on a computer-readable recording medium. A computer-readable recording medium includes all kinds of recording apparatuses in which data that can be read by a computer system is stored.

Examples of the computer-readable recording medium include a ROM, a RAM, a CD-ROM, a magnetic tape, a floppy disk, an optical data storage device and the like, and also a carrier wave (for example, transmission via the Internet) . In addition, the computer-readable recording medium may be distributed over network-connected computer systems so that computer readable codes can be stored and executed in a distributed manner. In addition, functional programs, codes, and code segments for implementing the present invention can be easily deduced by programmers skilled in the art to which the present invention belongs.

The present invention has been described above with reference to various embodiments. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is defined by the appended claims rather than by the foregoing description, and all differences within the scope of equivalents thereof should be construed as being included in the present invention.

0: measured object 1: blood glucose measuring device
10: source part
20: sensor part 23: dielectric resonator
25: inner hole 27: input / output terminal
30: Processor 35: Database
40:

Claims (15)

A source for generating electromagnetic energy of a predetermined frequency;
A sensor unit for receiving electromagnetic field energy generated from the source unit, irradiating the object to be measured with the electromagnetic field energy, and detecting a radio wave reflected from the object to be measured; And
And a processing unit for controlling the source unit to determine a resonance frequency of the sensor unit and calculating a change in blood sugar amount of the measured object from a change in resonance frequency and reflectance of the radio wave detected through the sensor unit,
The sensor unit includes:
A hole is formed in the center inside of the center where the electromagnetic energy is concentrated, and the object to be measured is inserted into the center inside of the cavity, forming a cavity structure in which the outside is metal and the inside is filled with air, And a dielectric resonator directly interacting with glucose in the measured object,
Wherein the hole formed in the center of the sensor portion is formed in a cylindrical shape so as to fix the measured object so that the measured object is positioned at the center of the dielectric resonator, Wherein a resolution according to a glucose concentration in the object is maintained above a threshold value. delete The method according to claim 1,
Wherein the sensor unit includes an input / output terminal formed with a coupling of a single port to reduce a radiation loss of the electromagnetic energy to the dielectric resonator. The method according to claim 1,
Wherein the sensor unit detects a wave reflected from the measured object by using a dielectric coefficient according to a frequency change and a reflection coefficient according to a glucose concentration in the measured object. . 5. The method of claim 4,
Wherein the dielectric constant is determined by a combination of an electric energy in the measured object and a loss of the electric energy. The method according to claim 1,
Wherein the processing unit generates visual data on a quantitative change in the blood sugar amount of the measured object by comparing a change in the resonance frequency and reflectance of the radio wave detected through the sensor unit with a previously stored database,
And a display unit for displaying the generated visual data. The method according to claim 1,
Wherein the sensor unit inspects the object to be measured non-invasively. An apparatus for measuring the concentration of glucose with a sensor,
The sensor includes:
A cavity is formed in the center inside of which the electromagnetic field energy is concentrated so that the object to be measured is inserted into the center inside of the cavity so that the glucose in the measured object and the center inside Directly interacting dielectric resonators; And
And an input / output terminal formed with coupling of a single port,
Wherein the hole formed in the center of the sensor is formed in a cylindrical shape so as to fix the object to be measured so that the object to be measured is positioned at the center of the dielectric resonator, The resolution is maintained above the threshold,
The electromagnetic energy is applied to the object to be measured through the dielectric resonator,
And detects a change in resonance frequency and reflectance of a radio wave reflected from the measured object as a result of interaction with the measured object. delete 9. The method of claim 8,
In the dielectric resonator of the cavity structure,
Wherein the outer portion is made of any one of aluminum (Al), copper (Cu), and stainless steel (SUS), or gold (Au) is coated on the surface of any one of the above metals. 9. The method of claim 8,
Wherein the sensor detects a wave reflected from the measured object by using a reflection coefficient according to a glucose concentration in the measured object and a dielectric constant according to a frequency change,
Wherein the electromagnetic energy and the electromagnetic wave are microwaves set in consideration of interaction with the object to be measured. Directly interacting with glucose in the object to be measured at the center inside of which the electromagnetic energy is concentrated by inserting the object to be measured into a hole formed in the center of the sensor having the dielectric resonator;
Receiving electromagnetic field energy of a predetermined frequency generated from a source;
The sensor irradiating the object to be measured with the input electromagnetic field energy;
Detecting a radio wave reflected from the measured object by the sensor; And
And calculating a change in blood glucose level of the measured object from a change in the resonance frequency and the reflectance of the detected radio wave,
The sensor includes:
Wherein a hole is formed in the center of the sensor to fix the object to be measured so that the object to be measured is positioned at the center of the dielectric resonator, Thereby maintaining the resolution of the blood glucose meter in the measured object that is indicative of the reproducibility of the sensor above a threshold value. 13. The method of claim 12,
Wherein the sensor detects a wave reflected from the measured object by using a reflection coefficient according to a glucose concentration in the measured object and a dielectric constant according to a frequency change,
Wherein the dielectric constant is determined by a combination of electrical energy in the measured object and loss of the electrical energy. 13. The method of claim 12,
Generating blood glucose amount information according to a resonance frequency and a reflectance of a radio wave and storing the information in a database in advance; And
Displaying visual data on a change in blood glucose level of the measured object through a display device,
The step of calculating the change in blood glucose level may include generating visual data on a quantitative change in blood glucose level of the measured object by comparing a change in the resonance frequency and reflectance of the radio wave detected through the sensor with a previously stored database . 13. The method of claim 12,
Wherein the sensor is non-invasively examining the measured object.

Images