CN117653091A - Wearable nondestructive blood glucose detection method based on microwave imaging - Google Patents
Wearable nondestructive blood glucose detection method based on microwave imaging Download PDFInfo
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- CN117653091A CN117653091A CN202211054506.1A CN202211054506A CN117653091A CN 117653091 A CN117653091 A CN 117653091A CN 202211054506 A CN202211054506 A CN 202211054506A CN 117653091 A CN117653091 A CN 117653091A
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- blood glucose
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- glucose concentrations
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- 239000008280 blood Substances 0.000 title claims abstract description 53
- 210000004369 blood Anatomy 0.000 title claims abstract description 53
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 36
- 239000008103 glucose Substances 0.000 title claims abstract description 36
- 238000001514 detection method Methods 0.000 title claims abstract description 17
- 238000003384 imaging method Methods 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 10
- 210000000707 wrist Anatomy 0.000 claims abstract description 8
- 238000009659 non-destructive testing Methods 0.000 claims abstract description 4
- 230000002641 glycemic effect Effects 0.000 claims abstract description 3
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- 238000012360 testing method Methods 0.000 claims abstract description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- 208000017442 Retinal disease Diseases 0.000 description 1
- 206010038923 Retinopathy Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention relates to a wearable nondestructive testing method for blood sugar based on microwave imaging, which comprises the following steps: manufacturing a human wrist model; configuring test samples with different blood glucose concentrations; calibrating and setting a vector network analyzer; reading time domain pulse signals with different blood sugar concentrations; processing the acquired time domain pulse by adopting a microwave imaging algorithm to obtain a corresponding microwave image; performing image processing on the microwave image, taking one of the characteristics (such as image gray value sum) as an example; comparing the gray scale of the microwave images with different blood glucose concentrations with the change of the blood glucose concentrations, and drawing a graph; for glycemic subject detection.
Description
Technical Field
The invention belongs to the field of biomedical detection and ultra-wideband microwave nondestructive detection, and relates to a novel ultra-wideband microwave noninvasive blood glucose concentration detection device.
Background
Diabetes is a chronic disease that can lead to a variety of complications, including stroke, myocardial infarction, retinopathy, diabetic nephropathy, and diabetic foot. Has become one of the most fatal diseases in the world. Therefore, diabetics need to constantly measure blood glucose levels to ensure timely medical attention, preventing exacerbations and complications. For normal persons, it is necessary to check the blood glucose level of the body regularly to prevent the risk of diabetes. The blood glucose level is clinically detected by drawing venous blood, the detection result of the method is the most standard, and in daily life, diabetics can also adopt a household blood glucose meter to take blood from fingertips for blood glucose detection. In order to monitor the blood sugar level of a diabetic patient in real time and reduce the pain and infection risk of blood sampling of the patient, a microwave noninvasive blood sugar detection method based on an ultra-wideband antenna can be adopted. The detection principle is that when the concentration of glucose in human blood changes, the dielectric properties of the blood also change, and when electromagnetic waves emitted by the ultra-wideband antenna penetrate through blood layers with different dielectric properties, the obtained receiving signals are different. Since electromagnetic sensors face frequency selection uncertainty problems, this results in a non-linear relationship between the detected signal and the true blood glucose concentration. Therefore, a microwave imaging technique is proposed for non-invasive blood glucose detection.
Disclosure of Invention
The invention provides a method for carrying out microwave nondestructive detection on blood glucose concentration of a human body by using an image identification method. The method is simple, convenient and quick, the blood glucose concentration can be judged through the characteristics extracted by the microwave image, the method harmful to human bodies such as puncture is avoided, and enough information can be acquired to detect the blood glucose concentration. The technical scheme of the invention is as follows:
a method for wearable non-destructive testing of blood glucose based on microwave imaging, comprising the steps of:
(1) Manufacturing a human wrist model;
(2) Configuring test samples with different blood glucose concentrations;
(3) Calibrating and setting a vector network analyzer;
(4) Reading time domain pulse signals with different blood sugar concentrations;
(5) Processing the acquired time domain pulse by adopting a microwave imaging algorithm to obtain a corresponding microwave image;
(6) Performing image processing on the microwave image, taking one of the characteristics (such as image gray value sum) as an example;
(7) Comparing the gray scale of the microwave images with different blood glucose concentrations with the change of the blood glucose concentrations, and drawing a graph;
(8) For glycemic subject detection.
Drawings
FIG. 1 measuring apparatus diagram
FIG. 2 time domain pulse signal diagrams of different blood glucose concentrations
FIG. 3 microwave images of different blood glucose concentrations
FIG. 4 microwave image characteristics versus blood glucose concentration
Detailed Description
The invention aims to overcome the defects of the existing invasive blood sugar detection, and provides a method for detecting the blood sugar concentration value at the wrist position of the human body with dense blood vessels by adopting a microwave imaging technology. Two ultra-wideband antennas are placed on two sides of a human wrist, microwave signals transmitted by a transmitting antenna are scattered by human tissues and blood and then received by a receiving antenna, and blood sugar with different concentrations is imaged by an imaging algorithm. Meanwhile, the ultra-wideband microwave signal has the advantages of low radiation power, large target information carrying capacity and the like, and can be used as a conventional means for nondestructive detection of blood glucose concentration. There is therefore a need to develop a method for wearable non-destructive testing of blood glucose based on microwave imaging.
The invention is described below with reference to the drawings and examples.
(1) The change in blood glucose concentration in the human body causes a change in permittivity of the blood. Thus, the microwave signal may be used to characterize the blood glucose concentration of a human. Because the blood vessels at the wrist part of the human body are denser, a plurality of receiving and transmitting antennas are deployed at the wrist part of the human body, and the noninvasive detection of the blood sugar of the human body can be realized by carrying out microwave imaging and image processing on different blood sugar concentrations.
(2) The antenna is connected to the vector network analyzer as shown in fig. 1, after which the vector network analyzer is calibrated and the desired operating frequency band is set.
(3) Glucose solutions with different concentrations are prepared and sequentially injected into a human wrist model in equal quantity, and time domain pulse signals are recorded through a vector network analyzer.
(4) And reading the time domain signals measured by the vector network analyzer, and drawing time domain waveform diagrams of different blood sugar concentrations of the time domain signals, as shown in fig. 2.
(5) The obtained microwave signals with different blood glucose concentrations are imaged by a microwave imaging algorithm, as shown in fig. 3. The obtained microwave image is subjected to feature extraction (such as image gray value sum), and the corresponding relation between the image features and the blood glucose concentration is analyzed to detect the blood glucose concentration, as shown in fig. 4.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
The foregoing is merely exemplary of the present application and is not intended to limit the present application. Various modifications and changes may be made to the present application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc. which are within the spirit and principles of the present application are intended to be included within the scope of the claims of the present application.
Claims (1)
1. A method for wearable non-destructive testing of blood glucose based on microwave imaging, comprising the steps of:
(1) Manufacturing a human wrist model;
(2) Configuring test samples with different blood glucose concentrations;
(3) Calibrating and setting a vector network analyzer;
(4) Reading time domain pulse signals with different blood sugar concentrations;
(5) Processing the acquired time domain pulse by adopting a microwave imaging algorithm to obtain a corresponding microwave image;
(6) Performing image processing on the microwave image, taking one of the characteristics (such as image gray value sum) as an example;
(7) Comparing the gray scale of the microwave images with different blood glucose concentrations with the change of the blood glucose concentrations, and drawing a graph;
(8) For glycemic subject detection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211054506.1A CN117653091A (en) | 2022-08-31 | 2022-08-31 | Wearable nondestructive blood glucose detection method based on microwave imaging |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211054506.1A CN117653091A (en) | 2022-08-31 | 2022-08-31 | Wearable nondestructive blood glucose detection method based on microwave imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117653091A true CN117653091A (en) | 2024-03-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211054506.1A Pending CN117653091A (en) | 2022-08-31 | 2022-08-31 | Wearable nondestructive blood glucose detection method based on microwave imaging |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117653091A (en) |
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2022
- 2022-08-31 CN CN202211054506.1A patent/CN117653091A/en active Pending
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