CN107997769A - A kind of microwave time delay Woundless blood sugar Concentration Testing method based on Ear lobe blood liquid layer - Google Patents
A kind of microwave time delay Woundless blood sugar Concentration Testing method based on Ear lobe blood liquid layer Download PDFInfo
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- CN107997769A CN107997769A CN201711191839.8A CN201711191839A CN107997769A CN 107997769 A CN107997769 A CN 107997769A CN 201711191839 A CN201711191839 A CN 201711191839A CN 107997769 A CN107997769 A CN 107997769A
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- blood
- blood sugar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
Abstract
The present invention relates to a kind of microwave time delay Woundless blood sugar Concentration Testing method based on Ear lobe blood liquid layer, comprise the following steps：Make ear-lobe model；Prepare the test blood of different blood sugar concentrations；Two antennas are placed in the both sides of ear-lobe model, transmitting antenna transmitting high_frequency sine wave signal, reception antenna receives the high_frequency sine wave signal through ear-lobe model；Change the blood sugar concentration that blood is tested in ear-lobe model, using the blood testing of different blood sugar concentrations, receive the sine wave of the blood through different blood sugar concentrations；Dock received signal and do time-domain analysis, find out time when waveforms amplitude is 0, sum up reception waveform and be compared to changing rule of the time delay of transmitted waveform on being tested blood blood sugar concentration；Measure time delay of the time domain waveform compared to transmitted waveform of blood to be measured, you can calculate the blood sugar concentration of tested blood.
Description
Technical field
The invention belongs to microwave Non-invasive detection technical field, is related to a kind of blood sugar concentration detection method.
Background technology
At present, diabetes have become non-communicable diseases popular in a kind of worldwide, detect blood glucose water on an empty stomach
The flat conventional project for having become physical examination, contributes to preliminary examination diabetes early stage patient.The blood glucose inspection clinically used at present
Survey method is mainly glucose oxidase (GOD) method, it is referred to as the goldstandard in clinical detection, and testing result is very accurate.
In addition, blood sugar test method further comprises the optical method in invasive detection, hypodermic implantation in minimally invasive detection and transdermal take
Sample method.These methods all bring considerable distress to patient, for diabetic, need to carry out for several times daily
Blood sugar test, a kind of noninvasive painless blood sugar detecting method urgently develops.Current Non-invasive detection method mainly passes through detection
Its hetero-organization (such as skin, cornea, oral mucosa, tongue and eardrum etc.) of body or body fluid (such as urine, saliva, sweat, tear
Liquid) in glucose content, calculated indirectly by mathematical method and, these method accuracys rate are low, with clinical method it is actual survey
It is larger to measure result difference.
The content of the invention
The present invention provides a kind of method using high_frequency sine wave Non-invasive detection human blood glucose concentration.The mesh of this method detection
Mark is organized as ear-lobe tissue, by comparing transmitting and receiving the time domain time delay of waveform, calculates opposite Jie of ear-lobe Tissue Blood liquid layer
Permittivity values, by blood sugar concentration and the correspondence of relative dielectric constant, calculate the glucose concentration level of patient indirectly.This
The method of sample avoids harmful invasive detection method, and technical scheme is as follows：
A kind of microwave time delay Woundless blood sugar Concentration Testing method based on Ear lobe blood liquid layer, comprises the following steps：
1) ear-lobe model is made；
2) the test blood of different blood sugar concentrations is prepared；
3) two antennas are placed in the both sides of ear-lobe model, transmitting antenna transmitting high_frequency sine wave signal, reception antenna connects
Receive the high_frequency sine wave signal through ear-lobe model；
4) change the blood sugar concentration that blood is tested in ear-lobe model, using the blood testing of different blood sugar concentrations, receive
Through the sine wave of the blood of different blood sugar concentrations；
5) dock received signal and do time-domain analysis, find out time when waveforms amplitude is 0, sum up reception waveform and compare
Compared with transmitted waveform time delay on be tested blood blood sugar concentration changing rule；
6) rule summarized according to step 5, measures time delay of the time domain waveform compared to transmitted waveform of blood to be measured, you can
Calculate the blood sugar concentration of tested blood.
Brief description of the drawings
Fig. 1 simplifies ear-lobe tissue model and antenna structure view
When Fig. 2 dielectric constants change between 68-70, the time domain beamformer of received wave
Embodiment
Fig. 1 is the naive model of ear-lobe institutional framework, for simplicity, in model divide into blood layer and skin layer,
To verify the validity of this method.Two antennas are individually positioned in the both sides of ear-lobe tissue, are respectively used to launch and receive high frequency
Sine wave.The concentration range of blood layer is 0~4000mg/dL, the blood layer electrical measurement parameter of corresponding various concentrations.
Detailed process is as follows：
1. ear-lobe tissue model is established as shown in Figure 1, transmitting antenna and reception antenna are all located at skin layer surface.
2. it is the single frequency sinusoidal ripple that frequency is 1GHz to set the waveform that transmitting antenna is sent, obtain receiving waveform.
3. change the relative permittivity value of blood layer so that relative dielectric constant changes between 68-70, represents blood
The change of liquid layer blood glucose concentration value.
It is opposite when blood as shown in Fig. 2, as seen from Figure 2 4. five reception curves are drawn on same image
When dielectric constant is 70 (i.e. blood sugar concentration is 0mg/dL), received wave is hereafter opposite to be situated between relative to transmitted wave delay 0.3971ns
Electric constant often reduces by 0.5, received wave delay increase 0.0014ns.
5. set received wave to be delayed as Δ t (units relative to transmitted wave：Ns), then it can be arranged by above-mentioned table 1, be tested blood
The blood sugar concentration of liquid is：
。
Claims (1)
1. a kind of microwave time delay Woundless blood sugar Concentration Testing method based on Ear lobe blood liquid layer, comprises the following steps：
1) ear-lobe model is made；
2) the test blood of different blood sugar concentrations is prepared；
3) two antennas are placed in the both sides of ear-lobe model, transmitting antenna transmitting high_frequency sine wave signal, reception antenna is received and worn
Cross the high_frequency sine wave signal of ear-lobe model；
4) change the blood sugar concentration that blood is tested in ear-lobe model, using the blood testing of different blood sugar concentrations, receive through
The sine wave of the blood of different blood sugar concentrations；
5) dock received signal and do time-domain analysis, find out time when waveforms amplitude is 0, sum up reception waveform and be compared to
Changing rule of the time delay of transmitted waveform on being tested blood blood sugar concentration；
6) rule summarized according to step 5, measures time delay of the time domain waveform compared to transmitted waveform of blood to be measured, you can calculates
Go out the blood sugar concentration of tested blood.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711191839.8A CN107997769A (en) | 2017-11-24 | 2017-11-24 | A kind of microwave time delay Woundless blood sugar Concentration Testing method based on Ear lobe blood liquid layer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711191839.8A CN107997769A (en) | 2017-11-24 | 2017-11-24 | A kind of microwave time delay Woundless blood sugar Concentration Testing method based on Ear lobe blood liquid layer |
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| Publication Number | Publication Date |
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| CN107997769A true CN107997769A (en) | 2018-05-08 |
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| CN201711191839.8A Pending CN107997769A (en) | 2017-11-24 | 2017-11-24 | A kind of microwave time delay Woundless blood sugar Concentration Testing method based on Ear lobe blood liquid layer |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108877445A (en) * | 2018-07-19 | 2018-11-23 | 天津大学 | A method of dividing blood distribution in shape reconstruct ear-lobe model based on DLA |
| CN110507331A (en) * | 2019-08-30 | 2019-11-29 | 上海海事大学 | A kind of invasive blood sugar measuring system based on ultrasonic velocity method |
| CN110729050A (en) * | 2019-09-01 | 2020-01-24 | 天津大学 | Method for establishing three-dimensional earlobe model for blood sugar detection |
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| CN102512175A (en) * | 2007-11-05 | 2012-06-27 | 生物传感器公司 | Optical sensor for determining the concentration of an analyte |
| CN106214158A (en) * | 2016-07-15 | 2016-12-14 | 天津大学 | A kind of blood sugar concentration detection method analyzed based on ultra-wideband microwave absorption spectra |
| CN106256319A (en) * | 2016-07-15 | 2016-12-28 | 天津大学 | A kind of blood sugar concentration detection method based on ultra-wideband microwave signal time frequency analysis |
| CN106419932A (en) * | 2016-07-15 | 2017-02-22 | 天津大学 | Blood sugar concentration detection method based on time-frequency analysis of ultra-wideband microwave signals |
| WO2017097276A1 (en) * | 2015-12-09 | 2017-06-15 | Diamontech Gmbh | Apparatus and method for analyzing a material |
| WO2017143129A1 (en) * | 2016-02-17 | 2017-08-24 | Tesseract Health, Inc. | Sensor and device for lifetime imaging and detection applications |
| WO2017188675A1 (en) * | 2016-04-29 | 2017-11-02 | 다담마이크로 주식회사 | Non-invasive blood sugar measurement method and device using optical reflectometry |
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- 2017-11-24 CN CN201711191839.8A patent/CN107997769A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512175A (en) * | 2007-11-05 | 2012-06-27 | 生物传感器公司 | Optical sensor for determining the concentration of an analyte |
| WO2017097276A1 (en) * | 2015-12-09 | 2017-06-15 | Diamontech Gmbh | Apparatus and method for analyzing a material |
| WO2017143129A1 (en) * | 2016-02-17 | 2017-08-24 | Tesseract Health, Inc. | Sensor and device for lifetime imaging and detection applications |
| WO2017188675A1 (en) * | 2016-04-29 | 2017-11-02 | 다담마이크로 주식회사 | Non-invasive blood sugar measurement method and device using optical reflectometry |
| CN106214158A (en) * | 2016-07-15 | 2016-12-14 | 天津大学 | A kind of blood sugar concentration detection method analyzed based on ultra-wideband microwave absorption spectra |
| CN106256319A (en) * | 2016-07-15 | 2016-12-28 | 天津大学 | A kind of blood sugar concentration detection method based on ultra-wideband microwave signal time frequency analysis |
| CN106419932A (en) * | 2016-07-15 | 2017-02-22 | 天津大学 | Blood sugar concentration detection method based on time-frequency analysis of ultra-wideband microwave signals |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108877445A (en) * | 2018-07-19 | 2018-11-23 | 天津大学 | A method of dividing blood distribution in shape reconstruct ear-lobe model based on DLA |
| CN110507331A (en) * | 2019-08-30 | 2019-11-29 | 上海海事大学 | A kind of invasive blood sugar measuring system based on ultrasonic velocity method |
| CN110729050A (en) * | 2019-09-01 | 2020-01-24 | 天津大学 | Method for establishing three-dimensional earlobe model for blood sugar detection |
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Application publication date: 20180508 |