CN110507331A - A kind of invasive blood sugar measuring system based on ultrasonic velocity method - Google Patents
A kind of invasive blood sugar measuring system based on ultrasonic velocity method Download PDFInfo
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- CN110507331A CN110507331A CN201910815470.6A CN201910815470A CN110507331A CN 110507331 A CN110507331 A CN 110507331A CN 201910815470 A CN201910815470 A CN 201910815470A CN 110507331 A CN110507331 A CN 110507331A
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- ultrasonic
- blood sugar
- dsp processor
- ultrasonic wave
- measuring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
Abstract
The present invention relates to a kind of invasive blood sugar measuring systems based on ultrasonic velocity method, include: dsp processor；Two ultrasonic probes respectively with dsp processor by circuit connection, and are individually positioned in the two sides of patient's detected part；Wherein the first ultrasonic probe is after the driving signal for receiving dsp processor sending, emit ultrasonic wave to detected part, ultrasonic wave is received and converted to electric echo signal by the second ultrasonic probe after passing through detected part, it is transmitted to dsp processor, dsp processor is according to ultrasonic wave launch time, ultrasonic wave receiving time, the characteristic of detected part, the spread speed of ultrasonic wave is calculated, simultaneously according to the blood sugar concentration-ultrasonic velocity indicatrix being stored in advance in dsp processor, corresponding blood glucose concentration value is obtained.Operation of the present invention is simple, and measurement is quick, and to patient's fanout free region, reaches accurate measurement under the conditions of noninvasive to blood glucose concentration value.
Description
Technical field
The present invention relates to a kind of blood sugar measuring system, in particular to a kind of Woundless blood sugar measurements based on ultrasonic velocity method
System belongs to the technical field of blood glucose measurement.
Background technique
Diabetes are a kind of metabolic diseases characterized by hyperglycemia.Hyperglycemia be then due to defect of insulin secretion,
Or its biological effect is impaired, or both has concurrently and cause.Diabetic is chronically at hyperglycemia state, will lead to various organs
Tissue, especially eye, kidney, heart, blood vessel, the chronic lesion of nerve and dysfunction.The particularity of diabetes determines blood
The monitoring of sugar plays very important effect in treating diabetes, and existing treating diabetes scheme is that glycemic control exists
In one zone of reasonableness, the dosage of drug is insufficient or excessive may all to be caused patient further to injure, therefore blood glucose is supervised
Examining system is indispensable in the process.
Currently used blood glucose measurement is that blood is taken to sample laggard promoting circulation of blood sugar detection by finger tip, although blood glucose value detected
It is more accurate, but long-term frequent blood sampling can all cause strong influence to the body and psychology of patient, therefore to nothing
The research of wound blood sugar measuring system is extremely important.
The detection of Woundless blood sugar mainly has optical method, electrochemical process and body fluid method at present.Optical method is vulnerable to individual difference
Cause light wave trap different, influences measurement result.Electrochemical process easily generates stimulation to skin and causes patient uncomfortable.Body fluid method institute
The correlation of the body fluid of acquisition and blood sugar concentration is not high and there are blood sugar concentration latency issues.Therefore above-mentioned various Woundless blood sugar inspections
Survey all has certain disadvantage and limitation.
Therefore, the present invention proposes a kind of invasive blood sugar measuring system based on ultrasonic velocity method, is had using ultrasonic wave
Convenient, the good directionality, the characteristics and advantages that penetration capacity is strong, harmless having are particularly suitable for Woundless blood sugar measurement neck
Domain.
Summary of the invention
It is easy to operate the object of the present invention is to provide a kind of invasive blood sugar measuring system based on ultrasonic velocity method, it surveys
Amount is quick, and to patient's fanout free region, reaches accurate measurement under the conditions of noninvasive to blood glucose concentration value.
To achieve the above object, the present invention provides a kind of invasive blood sugar measuring system based on ultrasonic velocity method, includes:
Dsp processor；Two ultrasonic probes respectively with the dsp processor by circuit connection, and are individually positioned in patient's
The two sides of detected part；Wherein the first ultrasonic probe is after the driving signal for receiving dsp processor sending, to detected part
Emit ultrasonic wave, ultrasonic wave is received and converted to electric echo signal by the second ultrasonic probe after passing through detected part, in turn
It is transmitted to dsp processor, dsp processor is according to ultrasonic wave launch time of the first ultrasonic probe, the second ultrasonic probe
Ultrasonic wave receiving time, the characteristic of detected part, are calculated the spread speed of ultrasonic wave, while according to being stored in advance in
Blood sugar concentration-ultrasonic velocity indicatrix in dsp processor, obtains corresponding blood glucose concentration value.
Wherein, according to the dull sexual intercourse between the blood sugar concentration in ultrasonic wave spread speed and blood in blood,
And according to ultrasonic grating experiment, velocity of wave of ultrasonic wave when through the blood of different blood sugar concentrations is calculated, and be fitted and obtain blood
The indicatrix of sugared concentration-ultrasonic velocity.
Wherein, the detected part is ear-lobe, and the characteristic of detected part is ear-lobe thickness.
Wherein, the characteristic of the detected part is stored in advance into dsp processor.
Wherein, the piezoelectric chip in each ultrasonic probe is arranged using linear array mode.
Wherein, the invasive blood sugar measuring system based on ultrasonic velocity method also includes: LCD display, and described
Dsp processor by circuit connection, the blood glucose concentration value shown.
Wherein, the invasive blood sugar measuring system based on ultrasonic velocity method also includes: D/A converter, and described
Dsp processor by circuit connection, digital-to-analogue conversion is carried out to the driving signal that dsp processor issues；First power amplification electricity
The driving for completing digital-to-analogue conversion is respectively believed by circuit connection with the D/A converter and the first ultrasonic probe in road
Number carry out power amplification processing to generate high-frequency ac electric signal, by the reversed piezoelcetric effect of the piezoelectric chip of the first ultrasonic probe
Ultrasonic wave is generated and transmitted by under the driving of the high-frequency ac electric signal.
Wherein, the frequency of the high-frequency ac electric signal is identical as the frequency of ultrasonic wave.
Wherein, the invasive blood sugar measuring system based on ultrasonic velocity method also includes: filter circuit, and described
The second ultrasonic probe by circuit connection, will be received by the direct piezoelectric effect of the piezoelectric chip of the second ultrasonic probe
Ultrasonic wave is converted to electric echo signal, and is transmitted to filter circuit and is filtered；Second power amplification circuit, and it is described
Filter circuit carries out power amplification processing by circuit connection, to the electric echo signal for completing filtering；A/D converter, respectively with
Second power amplification circuit and dsp processor by circuit connection, to complete the electric echo signal of power amplification into
Row analog-to-digital conversion, and it is transmitted to dsp processor.
In conclusion the invasive blood sugar measuring system provided by the present invention based on ultrasonic velocity method, easy to operate, survey
Amount is quick, and to patient's fanout free region, reaches accurate measurement under the conditions of noninvasive to blood glucose concentration value.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the invasive blood sugar measuring system of the invention based on ultrasonic velocity method；
Fig. 2 is ultrasonic grating experiment figure of the invention.
Specific embodiment
Below in conjunction with FIG. 1 to FIG. 2, by preferred embodiment to technology contents of the invention, construction feature, reached purpose
And effect is described in detail.
As shown in Figure 1, being the invasive blood sugar measuring system provided by the invention based on ultrasonic velocity method, include: DSP
(Digital Signal Processing, Digital Signal Processing) processor 8；Two ultrasonic probes, respectively with it is described
Dsp processor 8 is individually positioned in the two sides of the detected part of patient by circuit connection；Wherein the first ultrasonic probe 1 exists
Receive dsp processor 8 sending driving signal after, to detected part emit ultrasonic wave, ultrasonic wave pass through detected part it
Electric echo signal is received and converted to by the second ultrasonic probe 2 afterwards, and then is transmitted to dsp processor 8, dsp processor 8 docks
The ultrasonic echo electric signal received is handled, according to the ultrasonic wave launch time of the first ultrasonic probe 1, the second ultrasonic wave
Ultrasonic wave receiving time, the characteristic of detected part of probe 2, are calculated the spread speed of ultrasonic wave, while according to pre-
Blood sugar concentration-ultrasonic velocity the indicatrix being first stored in dsp processor 8, obtains corresponding blood glucose concentration value.
When being propagated in the medium due to ultrasonic wave, velocity of wave will receive the influence of concentration of medium.Ultrasonic wave is in blood
Blood sugar concentration in spread speed and blood has good dull sexual intercourse, i.e., when blood sugar concentration increases, ultrasonic wave is being worn
Reflectivity in saturating blood path can increase with the rate of being absorbed by the blood with the increase of blood sugar concentration, as a result ultrasonic wave
Velocity of wave can increase with the increase of blood blood sugar concentration.Using the velocity of wave of ultrasonic wave and this monotonic nature of blood sugar concentration,
Velocity of wave of the ultrasonic wave when passing through blood is obtained by calculation, corresponding blood glucose concentration value can be obtained.
Further, since ultrasonic grating phenomenon can be generated when ultrasonic wave is propagated in a liquid as a kind of longitudinal wave.Such as figure
Shown in 1, S is visible light source；L1, L2 are convex lens；M is solution tank, wherein brilliant containing PZT (lead titanate piezoelectric ceramics)
Piece；H is visible light in the diffraction fringe band successively formed after convex lens L1, solution tank M and convex lens L2.In the ultrasound
In grating experiment, sonic oscillation is generated by the oscillator being made of PZT chip, at this point, passing through the super of the solution in solution tank M
The velocity of wave expression formula of sound wave are as follows: V=k λ f γ/lk；Wherein, k indicates that k grades of bright lines, λ are the wavelength of visible light, and f is lens L2's
Focal length, γ are the vibration frequency of the PZT chip in solution tank M, lkFor the distance between k grades of bright lines and central bright fringe, thus may be used
The ultrasonic velocity by solution is calculated.Based on above-mentioned ultrasonic grating principle, calculates ultrasonic wave and passing through different blood glucose
The velocity of wave when blood of concentration, so as to be fitted to obtain the indicatrix between blood sugar concentration C and ultrasonic velocity V, and will
This feature curve is stored in dsp processor 8.
In a preferred embodiment of the invention, the detected part is chosen for ear-lobe, the characteristic choosing of detected part
It is taken as ear-lobe thickness, the characteristic of the detected part is stored in advance into the dsp processor 8.Due to ear-lobe position
Capillary is abundant, and blood flow velocity is slow, while can be avoided influence of the skeleton to ultrasound signal receipt.Therefore at this
In invention, two ultrasonic probes are individually positioned in the two sides of patient's ear-lobe, the ear-lobe thickness passed through according to ultrasonic wave, with
And two ultrasonic probes emit respectively and receive the time of ultrasonic wave, and biography of the ultrasonic wave when passing through blood samples of patients is calculated
Broadcast speed.
In a preferred embodiment of the invention, the piezoelectric chip in each ultrasonic probe is arranged using linear array mode
Column, the arrangement mode of such piezoelectric chip are more sensitive for the variation of various parameters amount in ultrasonic echo.
In a preferred embodiment of the invention, the invasive blood sugar measuring system based on ultrasonic velocity method, is also wrapped
Contain: LCD (Liquid Crystal Display, liquid crystal display) display 9 is connected with the dsp processor 8 by circuit
It connects, for showing the blood glucose concentration value being calculated.
In a preferred embodiment of the invention, the invasive blood sugar measuring system based on ultrasonic velocity method, is also wrapped
Contain: D/A (D/A) converter 4 believes the driving that dsp processor 8 issues with the dsp processor 8 by circuit connection
Number carry out digital-to-analogue conversion；First power amplification circuit 3 is logical with the D/A converter 4 and the first ultrasonic probe 1 respectively
Oversampling circuit connection carries out power amplification to the driving signal for completing digital-to-analogue conversion and handles to generate high-frequency ac electric signal, by the
The reversed piezoelcetric effect of the piezoelectric chip of one ultrasonic probe 1 is generated and transmitted by ultrasound under the driving of the high-frequency ac electric signal
Wave.
Wherein, the frequency of the high-frequency ac electric signal is identical as the frequency of ultrasonic wave.
In a preferred embodiment of the invention, the invasive blood sugar measuring system based on ultrasonic velocity method, is also wrapped
Contain: filter circuit 5, with second ultrasonic probe 2 by circuit connection, by the piezoelectric chip of the second ultrasonic probe 2
Direct piezoelectric effect the ultrasonic wave received is converted into electric echo signal, and be transmitted to filter circuit 5 and be filtered；The
Two power amplification circuits 6 carry out power to the electric echo signal for completing filtering with the filter circuit 5 by circuit connection
Enhanced processing；A/D (analog/digital) converter 7, passes through electricity with second power amplification circuit 6 and dsp processor 8 respectively
Road connection carries out analog-to-digital conversion to the electric echo signal for completing power amplification, and is transmitted to dsp processor 8, by dsp processor 8
Electric echo signal is handled, the spread speed of ultrasonic wave is calculated.
Therefore, the invasive blood sugar measuring system of the present invention based on ultrasonic velocity method, using ultrasonic wave in difference
The different characteristic of spread speed in blood under blood glucose concentration value obtains the indicatrix of ultrasonic velocity and blood sugar concentration, and
By measuring the ultrasonic velocity across blood samples of patients to which correspondence obtains blood glucose concentration value.Specifically, the Woundless blood sugar measures
System is by two ultrasonic probes, D/A converter, the first power amplification circuit, filter circuit, the second power amplification circuit, A/D
Converter, dsp processor, LCD display connect and compose.The indicatrix quilt of ultrasonic velocity and blood sugar concentration mentioned above
It is stored in advance in dsp processor, two ultrasonic probes is individually positioned in the two sides of patient's detected part, are respectively used to send out
Ultrasonic wave is penetrated and received, the transmitting and receiving time of the thickness and ultrasonic wave of detected part are obtained by measuring, by DSP
The spread speed of ultrasonic wave is calculated in reason device, to find on indicatrix of the ultrasonic velocity with blood sugar concentration corresponding
Blood glucose concentration value.
In conclusion the invasive blood sugar measuring system provided by the present invention based on ultrasonic velocity method, easy to operate, survey
Amount is quick, and to patient's fanout free region, reaches accurate measurement under the conditions of noninvasive to blood glucose concentration value.
It is discussed in detail although the contents of the present invention have passed through above preferred embodiment, but it should be appreciated that above-mentioned
Description is not considered as limitation of the present invention.After those skilled in the art have read above content, for of the invention
A variety of modifications and substitutions all will be apparent.Therefore, protection scope of the present invention should be limited to the appended claims.
Claims (9)
1. a kind of invasive blood sugar measuring system based on ultrasonic velocity method, characterized by comprising:
Dsp processor；
Two ultrasonic probes respectively with the dsp processor by circuit connection, and are individually positioned in the portion to be measured of patient
The two sides of position；
Wherein the first ultrasonic probe emits ultrasonic wave to detected part after the driving signal for receiving dsp processor sending,
Ultrasonic wave is received and converted to electric echo signal by the second ultrasonic probe after passing through detected part, and then is transmitted at DSP
Device is managed, when dsp processor is received according to the ultrasonic wave launch time of the first ultrasonic probe, the ultrasonic wave of the second ultrasonic probe
Between, the characteristic of detected part, be calculated the spread speed of ultrasonic wave, while according to being stored in advance in dsp processor
Blood sugar concentration-ultrasonic velocity indicatrix, obtain corresponding blood glucose concentration value.
2. the invasive blood sugar measuring system as described in claim 1 based on ultrasonic velocity method, which is characterized in that according to ultrasound
The dull sexual intercourse between blood sugar concentration in the spread speed and blood of wave in blood, and according to ultrasonic grating experiment,
Velocity of wave of ultrasonic wave when through the blood of different blood sugar concentrations is calculated, and is fitted and obtains blood sugar concentration-ultrasonic velocity spy
Levy curve.
3. the invasive blood sugar measuring system as described in claim 1 based on ultrasonic velocity method, which is characterized in that it is described to
Survey position is ear-lobe, and the characteristic of detected part is ear-lobe thickness.
4. the invasive blood sugar measuring system as claimed in claim 3 based on ultrasonic velocity method, which is characterized in that it is described to
The characteristic for surveying position is stored in advance into dsp processor.
5. the invasive blood sugar measuring system as described in claim 1 based on ultrasonic velocity method, which is characterized in that each described
Ultrasonic probe in piezoelectric chip arranged using linear array mode.
6. the invasive blood sugar measuring system as described in claim 1 based on ultrasonic velocity method, which is characterized in that also include:
LCD display, with the dsp processor by circuit connection, the blood glucose concentration value shown.
7. the invasive blood sugar measuring system as claimed in claim 5 based on ultrasonic velocity method, which is characterized in that also include:
D/A converter carries out digital-to-analogue to the driving signal that dsp processor issues with the dsp processor by circuit connection
Conversion；
First power amplification circuit, respectively with the D/A converter and the first ultrasonic probe by circuit connection, to complete
Power amplification is carried out at the driving signal of digital-to-analogue conversion to handle to generate high-frequency ac electric signal, by the pressure of the first ultrasonic probe
The reversed piezoelcetric effect of electric chip is generated and transmitted by ultrasonic wave under the driving of the high-frequency ac electric signal.
8. the invasive blood sugar measuring system as claimed in claim 7 based on ultrasonic velocity method, which is characterized in that the height
The frequency of frequency ac signal and the frequency of ultrasonic wave are identical.
9. the invasive blood sugar measuring system as claimed in claim 5 based on ultrasonic velocity method, which is characterized in that also include:
Filter circuit, with second ultrasonic probe by circuit connection, by the piezoelectric chip of the second ultrasonic probe
The ultrasonic wave received is converted to electric echo signal by direct piezoelectric effect, and is transmitted to filter circuit and is filtered；
Second power amplification circuit carries out the electric echo signal for completing filtering with the filter circuit by circuit connection
Power amplification processing；
A/D converter, respectively with second power amplification circuit and dsp processor by circuit connection, to completion function
The electric echo signal of rate amplification carries out analog-to-digital conversion, and is transmitted to dsp processor.
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| CN107595318A (en) * | 2017-09-21 | 2018-01-19 | 中国科学院长春光学精密机械与物理研究所 | A kind of Woundless blood sugar concentration detection method and equipment |
| CN107997769A (en) * | 2017-11-24 | 2018-05-08 | 天津大学 | A kind of microwave time delay Woundless blood sugar Concentration Testing method based on Ear lobe blood liquid layer |
| CN109350078A (en) * | 2018-10-19 | 2019-02-19 | 天津大学 | Blood sugar concentration detection method based on ultra-wideband microwave inverse Fourier transform |
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2019
- 2019-08-30 CN CN201910815470.6A patent/CN110507331A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5119819A (en) * | 1990-05-02 | 1992-06-09 | Miles Inc. | Method and apparatus for non-invasive monitoring of blood glucose |
| CN101099667A (en) * | 2002-10-18 | 2008-01-09 | 塞尔-克姆有限责任公司 | Direct manual examination of remote patient with virtual examination functionality |
| CN100998507A (en) * | 2007-01-08 | 2007-07-18 | 何宗彦 | Atraumatic quick-action blood-sugar measuring apparatus and application method thereof |
| CN101011238A (en) * | 2007-02-02 | 2007-08-08 | 华南师范大学 | Image-forming method and device for detecting HIFU action effect |
| CN204708880U (en) * | 2015-06-18 | 2015-10-21 | 曹建华 | Small intelligent ultrasonic depth finder |
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