CN100998507A - Atraumatic quick-action blood-sugar measuring apparatus and application method thereof - Google Patents
Atraumatic quick-action blood-sugar measuring apparatus and application method thereof Download PDFInfo
- Publication number
- CN100998507A CN100998507A CN 200710200028 CN200710200028A CN100998507A CN 100998507 A CN100998507 A CN 100998507A CN 200710200028 CN200710200028 CN 200710200028 CN 200710200028 A CN200710200028 A CN 200710200028A CN 100998507 A CN100998507 A CN 100998507A
- Authority
- CN
- China
- Prior art keywords
- detection
- temperature
- detect
- microwave
- extension set
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims description 23
- 210000004369 blood Anatomy 0.000 claims abstract description 114
- 239000008280 blood Substances 0.000 claims abstract description 113
- 238000010438 heat treatment Methods 0.000 claims abstract description 81
- 238000004891 communication Methods 0.000 claims abstract description 12
- 238000001514 detection method Methods 0.000 claims description 146
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 62
- 239000008103 glucose Substances 0.000 claims description 62
- 238000012544 monitoring process Methods 0.000 claims description 31
- 238000001816 cooling Methods 0.000 claims description 29
- 239000000523 sample Substances 0.000 claims description 29
- 238000012360 testing method Methods 0.000 claims description 29
- 238000006243 chemical reaction Methods 0.000 claims description 18
- 238000012545 processing Methods 0.000 claims description 15
- 210000001519 tissue Anatomy 0.000 claims description 13
- 230000009471 action Effects 0.000 claims description 12
- 230000005540 biological transmission Effects 0.000 claims description 10
- 230000006870 function Effects 0.000 claims description 10
- 210000000707 wrist Anatomy 0.000 claims description 8
- 210000000056 organ Anatomy 0.000 claims description 7
- 238000005516 engineering process Methods 0.000 claims description 6
- 238000003860 storage Methods 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 5
- 238000004458 analytical method Methods 0.000 claims description 4
- 230000007423 decrease Effects 0.000 claims description 4
- 238000011835 investigation Methods 0.000 claims description 4
- 230000014759 maintenance of location Effects 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 210000003462 vein Anatomy 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 230000000052 comparative effect Effects 0.000 claims description 3
- 206010033675 panniculitis Diseases 0.000 claims description 3
- 210000004304 subcutaneous tissue Anatomy 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims 1
- 238000010998 test method Methods 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 description 33
- 239000004065 semiconductor Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 235000021152 breakfast Nutrition 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 210000005224 forefinger Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 235000019420 glucose oxidase Nutrition 0.000 description 3
- 210000004247 hand Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000007446 glucose tolerance test Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 229910001006 Constantan Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000020805 dietary restrictions Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 230000005674 electromagnetic induction Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000010295 mobile communication Methods 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000007410 oral glucose tolerance test Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
Images
Abstract
A non-invasive fast blood sugar tester able to monitor multiple patient at same time is composed of a casing, a panel with at least one horn opening from which a central axle of a heating head is projected, a display screen, a power supply port, a computer communication port, a power switch and several indicating lamps, a central control chip, a microwave generator connected to said heating head, a DC power supply, a microwave power regulator, temp detecting and controlling unit, temp regulator, time regulator, and temp sensor on the top of said central axle of heating head. Its test method is also disclosed.
Description
(1) technical field
The present invention relates to a kind of non-wound rapid blood sugar checkout equipment and detection method thereof.
(2) background technology
The tradition blood sugar test has been wound and has detected, and usually extracts patient or instrument detected person's blood continually, has both made misery, has brought the risk that infects again in the blood drawing process.The Woundless blood sugar checkout equipment of developing is at present disturbed by other factors easily, accuracy rate is not high, power consumption is many, volume is big, detection speed is slow, needs frequent high glucose oxidase enzyme test peper or the probe of price that use, and needs frequently to demarcate, the equipment complexity, cost is higher, can not realize the real-time monitoring of blood glucose, more can't monitor a plurality of patients at 24 hours simultaneously.
(3) summary of the invention
The purpose of this invention is to provide a kind of non-wound rapid blood sugar detector and blood sugar detecting method thereof, mainly solve noinvasive, detect the problem of blood glucose quickly and easily; Also solve the problem of simplified apparatus structure, reduction equipment cost; And the solution detector can't regularly detect and report to the police, can't monitor simultaneously at 24 hours a plurality of patients' problem; Solve the problem that patient's long periods of wear detects simultaneously.
The object of the present invention is achieved like this: this non-wound rapid blood sugar detector, comprise a shell, it is characterized in that: have at least one to detect horn mouth in case surface, stretch out the central shaft of a heating head in this detection horn mouth, the upper end of the central shaft of this heating head protrudes in case surface, and the lower end is connected with microwave generator in the shell through coaxial cable; Also have a display screen above the shell, this display screen is connected with the data output end signal of central die in the shell; This shell also is connected with action button with power interface, computer communication interface, on and off switch, detection display lamp;
A central die is arranged in the shell, this central die has control sequence in advance and is connected with the temperature detection control unit with dc source circuit unit respectively, above-mentioned dc source circuit unit is connected with microwave generator, said temperature detects control unit and connects a temperature sensing probe, this temperature sensing probe is positioned at the top of heating head, also be equipped with a cooling fan in the above-mentioned shell, the air inlet of cooling fan has air stream outlet facing to microwave generator on the shell.
Above-mentioned detection horn mouth inner wall shape is taper seat or quadratic surface, and inner wall surface scribbles a reflectance coating.
Above-mentioned shell is a box-type shell, central die respectively with the microwave power regulon, be used for monitoring temperature with to the temperature detection control unit of central die transmission variations in temperature eigenvalue, be used to be provided with the time regulon that increases and decreases the thermostat unit of regulating preset temperature range, be used to adjust the length of microwave heating time and be connected.
Above-mentioned shell is the watch style shell, and central die links together with clock unit and communication component respectively.
Above-mentioned detector connects the network structure that the detection extension set more than is formed by the detection main frame of a connection computer, the computer communication interface of every detection extension set through wire net with the detection main frame be connected with computer;
Computer: send monitored instruction, the viewing system working condition is retrieved for examination patient's blood glucose data and out of Memory, input preset temperature range, calculating parameter, conversion relation formula or curve;
Detect main frame and accept the instruction that regularly detected in a day 24 hours that the operator sends, and will instruct timed sending to detect extension set to each; Accept respectively to detect the detection data that extension set is sent; Analyzing and processing data calculates the blood glucose value that respectively detects the extension set detected person, and stores and demonstration; For the detection mistake that occurs for some reason, judgment data lost efficacy, and made mistakes from trend and detected extension set and send the instruction of resurveying, and data are reaffirmed analysis to resurveying; Detect the whether unusual situation of extension set detected person blood glucose value according to each, send alarm signal; According to different detected persons' situation, set up different preset temperature range and calculating parameter or conversion relation formula, calculate to make things convenient for blood glucose;
What be ready at any time respectively detects extension set in case accept to carry out the detection instruction that the detection main frame regularly sends, the microwave generator of start detection extension set immediately, by coaxial cable microwave is delivered to and to be worn on detected person's heating head on one's body, central shaft by heating head applies microwave to the skin and the subcutaneous tissue of contact position, monitor this regional temperature change dynamics simultaneously, automatically close microwave after detecting end, detect extension set and enter armed state once more; The temperature data that records is sent back computer in real time, for analyzing and processing; Each detects extension set and connects heating head by coaxial cable, is used for transmitting detecting the microwave that extension set sends, and heating head is fixed on the monitoring position of detecting the extension set detected person for a long time.
The non-wound rapid blood sugar detecting method of above-mentioned non-wound rapid blood sugar detector, it is as follows to it is characterized in that mainly detecting step:
Step a: preset temperature range in the selected common shell temperature scope that preheats the zone, preestablishes detected person's per day shell temperature scope according to concrete patient;
Step b: preliminary examination, the detected person will detect position skin and be attached on the detection horn mouth, start back central die is sent instruction, make the temperature detection control unit begin initial temperature, temperature detection result is compared with the preset temperature range in being stored in chip, as surpassing this scope by the temperature sensing probe detection of skin, central die judges, temporarily will not detect, and show " wait " information on display screen, position to be detected temperature detects after reaching the requirement temperature range again;
Step c: the formal detection, after confirming that test section megadyne temperature degree has reached the preset temperature range of permission, central die is sent the instruction of formal detection, allow microwave generator by predefined power, frequency and action time begin to send microwave, simultaneously detect display lamp begin the flicker; The technology that adopts microwave emission and temperature detection to hocket, the central shaft that two kinds of shared time scale scopes of process are 1: 1 to 50: 1 microwave by coaxial cable and heating head is drawn towards the palm of the hand, by temperature detecting unit when beginning to heat or from a certain moment, surveyed area is begun to carry out temperature monitoring, finish or finish a certain moment of back up to heating and stop, and representative variations in temperature characteristic value data is transferred to central die stores;
Steps d: date processing, after microwave heating stops, the detection display lamp extinguishes, central die will be carried out analyzing and processing to the data of all storages, by preset program representative variations in temperature eigenvalue and memory information are made comparisons, correlation curve or conversion relation formula according to variations in temperature feature and blood glucose calculates capillary tube whole blood blood glucose concentration value simultaneously, and shows by LCDs;
Step e: the cooling instrument, after detection is finished, detect the position and leave horn mouth, central die provides instruction, starts cooling fan, and blow air cooling instrument after cooling fan stops, being turned off on and off switch, waits for detection next time; The detected person accesses the testing result that is stored in to pass by in the central die in one period by the blood glucose level data in button investigation a period of time of seeing over or by computer interface, and unloading is in computer or to deliver to hospital for reference.
Above-mentioned non-wound rapid blood sugar detecting method is characterized in that: above-mentioned detection position skin comprises: have any zone of skin in all body surfaces or be exposed to the outer and human organ that is easy to measure or tissue that outer skin, corium, veins beneath the skin and other external heat source can affact.
The non-wound rapid blood sugar detecting method of above-mentioned non-wound rapid blood sugar detector, it is as follows to it is characterized in that mainly detecting step:
Step I, the detected person is worn to wrist with detector, and allowing the heating head and the temperature sensing probe that detect in the horn mouth be pressed on the wrist skin, the initial temperature before each the detection is basic identical, thereby need not consider initial temperature scope and corresponding preheating pre-cooling function;
Step II is started on and off switch, and central die is sent instruction, makes microwave generator send microwave, and simultaneous temperature sensor probe monitoring Heating Zone Temperature changes, and after testing result passes to central die, calculates and demonstrate blood glucose value, storage simultaneously or warning;
Step II I, after detection was finished, instrument stopped heating automatically, according to the default assay intervals time, reheats detection automatically;
Step IV, detect finish after, be stored in the central die in the past the testing result in one period, send to hospital or give the household for reference by cell-phone function.
The non-wound rapid blood sugar detecting method of above-mentioned non-wound rapid blood sugar detector, it is as follows to it is characterized in that mainly detecting step:
Step 3, N passage detect extension set and are ready to complete, and send " can detect " signal to detecting main frame;
After step 4, detection main frame receive that the N passage detects the extension set signal, pick up counting;
Step 9, detection main frame will be preserved data and the comparison of default blood glucose danger warning scope;
As do not exceed default blood glucose risk range, enter step 12
After step 13, the warning, the N passage suspends detection, treats to restart after medical personnel handle, and gets back to step 2.
The present invention compares the beneficial effect that has with existing conventional art:
When 1, this Woundless blood sugar detection method began to detect, the initial temperature of skin not necessarily leaves no choice but accurately equal preset temperature could begin formal heating detection.What the present invention provided is the temperature range of a permission, rather than a temperature value accurately.As long as the difference of initial temperature and preset temperature within a given scope, just can begin to detect, its result also has high accuracy.If initial temperature is not in given preset temperature range, can carry out preheating or precooling treatment to surveyed area by instrument, but also can allow tester oneself indoorly simply wait for a period of time, detect again after waiting test section megadyne temperature degree to reach requirement by suitable means (as washing one's hands) or in that temperature is more constant with cold water or hot water.
2, microwave generator adopts semiconductor device to produce microwave, has reduced equipment cost, has also reduced equipment volume.
3, temperature monitoring can also can adopt non-contacting infrared probe, thereby improve the suitability of equipment with the sensor probe that directly contacts skin.
4, adopt the detection head of horn mouth shape, make after microwave from coaxial cable enters in the horn mouth, not only can from the cavity of palm and horn mouth formation, not overflow, can also concentrate on the pocket that acts on central shaft and contact skin place, strengthen heats.Thereby produce significant heats with less output or microwave intensity.
5, the technology that adopts microwave emission and temperature detection to hocket has reduced the interference of microwave emission to temperature sensor.
6, same detector can have one with upper channel, and each passage can make testing result more accurate corresponding to different detection positions (as the left hand and the right hand) or different detection people, detects more quick and easy.
7, design energy detected person long periods of wear, but the monitor that self-timing detects and reports to the police, and equipment is convenient for carrying, and can make the detected person monitor blood sugar effects at any time, and can realize a tractor serves several purposes.
8, the multichannel blood glucose monitoring system is made up of a detection main frame and a plurality of detection extension set, can monitor a plurality of patients simultaneously in one day 24 hours.
Be below adopt the present invention carry out partial results that blood sugar test obtains and with the contrast that the wound testing result is arranged.
(1), with wound blood sugar test data contrast experiment is arranged
Instrument parameter of the present invention: external power supply: AC 220V/50Hz, Overall Power Consumption: 20W, output: 2W, operating frequency: 915MHz, power density: 30mW/cm
2, action time: 60s, detection time: 110s, maximum temperature :≤33 ℃, radiation leakage: 0.0W/cm
2, detection range: 1-25mmol/L, accuracy of detection :+/-0.5mmol/L, resolution: 0.1mmol/L, sense channel: 4, preset temperature range 26-28 ℃.
There is invasive blood-sugar detecting instrument information as follows: the full TM vigor of model Luo Kang type (ACCU-CHECK) blood-sugar detecting instrument.Need blood volume 1-2 microlitre, detecting reagent paper is the glucose oxidase enzyme test peper.200 of memory data outputs.The blood glucose unit of display: mmol/L
Detected object: A (blood glucose normal male, 35 years old);
| Detection time | The forefinger measured value | The wound measured value is arranged | Relative error ((having-do not have)/do not have) |
| 08:50 (breakfast) 09:05 09:25 09:55 10:25 10:55 11:25 11:55 12:30 13:00 (Chinese meal) 13:07 13:37 14:07 14:37 15:07 16:07 16:37 | 4.7 5.8 5.1 6.5 7.1 5.1 5.1 5.1 5.3 5.7 5.5 5.6 6.8 6.3 6.6 | 4.4 6.2 5.0 6.4 7.0 5.1 5.1 5.3 5.1 6.0 5.9 5.4 6.9 6.3 6.8 | -6.4％ 6.9％ 1.9％ -1.5％ -1.4％ 0.0％ 0.0％ 3.9％ -3.8％ 5.3％ 7.3％ -3.6％ 1.5％ 0.0％ 3.0％ |
Annotate: differ from and be no more than 1 minute two kinds of detection time
(2) right-hand man's glucose tolerance experiment (GTT)
Instrument parameter: (ditto)
Glucose tolerance test (OGTT) rule:, before should avoid using glycometabolic ethanol of influence and medicine, fasting at least 10 hours (but can drink water) before the test therebetween not carrying out in dietary restriction and the early morning (morning) after normal physical exertion 2-3 days.Allow the experimenter drink to contain the aqueous solution 250-300 milliliter of 75 gram glucose powders (or 82.5 gram monosaccharide), detection immediately after drink in 5 minutes.
Detected object: B (blood glucose normal male, 27 years old)
| Detection time | The left hand measured value | Detection time | Right hand measured value | Relative error ((right side-left side)/left side) |
| 8:37 8:47 8:57 9:00 (drink G/W) 9:07 9:17 9:27 9:37 9:47 9:57 10:07 10:17 10:27 10:37 10:47 10:57 11:07 11:17 11:27 11:37 11:47 | 5.1 5.4 5.0 5.6 5.4 5.3 7.9 7.4 6.9 8.0 4.9 5.6 6.3 5.6 5.4 4.9 5.4 6.0 6.1 6.6 | 8:40 8:50 8:58 9:08 9:19 9:29 9:40 9:50 10:00 10:09 10:19 10:29 10:39 10:49 10:59 11:09 11:19 11:29 11:39 11:49 | 4.9 5.2 5.0 5.3 5.4 5.3 8.3 7.5 7.0 7.7 4.9 5.3 6.0 5.5 5.3 5.2 5.3 5.7 5.8 6.3 | -3.9％ -3.7％ 0.0％ -5.4％ 0.0％ 0.0％ 5.0％ 1.4％ 1.4％ -3.8％ 0.0％ -5.4％ -4.8％ -1.8％ -1.9％ 6.1％ -1.9％ -5.0％ -4.9％ -4.5％ |
(2) with wound blood sugar test data contrast experiment is arranged
Instrument parameter: (ditto) has invasive blood-sugar detecting instrument information (ditto)
Detected object: C (the carbohydrate tolerance person of going down, man, 52 years old)
| Detection time | The forefinger measured value | The wound measured value is arranged | Relative error ((having-do not have)/do not have) |
| 08:00 (breakfast) 09:22 09:52 10:30 | 7.6 5.5 6.9 | 7.7 5.3 6.4 | 1.3％ -3.6％ -7.2％ |
| 11:00 11:30 12:00 (Chinese meal) 13:38 14:00 14:34 15:00 16:30 | 6.7 7.7 5.9 6.8 6.4 5.9 7.3 | 6.8 7.9 6.0 6.9 6.0 5.9 7.8 | 1.5％ 2.6％ 1.7％ 1.5％ -6.2％ 0.0％ 6.8％ |
Annotate: differ from and be no more than 1 minute two kinds of detection time
Detected object: D (diabetics, woman, 30 years old)
| Detection time | The forefinger measured value | The wound measured value is arranged | Relative error ((having-do not have)/do not have) |
| 08:50 (breakfast) 10:42 11:10 11:40 12:00 (Chinese meal) 12:30 13:08 13:34 14:00 14:30 | 9.0 11.1 10.8 10.1 9.3 8.7 13.0 8.5 | 9.4 12.3 11.6 10.5 9.2 8.1 14.0 8.9 | 4.4％ 10.8％ 7.4％ 4.0％ -1.1％ 4.6％ 7.7％ 4.7％ |
Detected object: E (diabetics, man, 32 years old)
| Detection time | The forefinger measured value | The wound measured value is arranged | Relative error ((having-do not have)/do not have) |
| 08:50, (breakfast) 10:49 11:19 11:50 12:00, (Chinese meal) 12:33 13:05 | 13.9 12.1 11.8 11.6 9.0 | 14.8 10.9 13.0 12.7 8.5 | 6.4％ 9.9％ 10.2％ 9.5％ -5.6％ |
| 13:37 14:00 14:32 14:52 15:30 16:26 | 5.7 10.0 6.0 6.8 8.0 10.7 | 5.2 9.4 5.2 6.7 7.6 11.7 | -8.8％ -6.0％ 13.3％ 1.5％ 5.0％ 9.3％ |
Advantage of the present invention: (1) when beginning to detect, the initial temperature of skin not necessarily leaves no choice but accurately equal preset temperature could begin formal heating detection.As long as the difference of initial temperature and preset temperature within a given scope, just can begin to detect, its result also has high accuracy.That is to say that what the present invention provided is the temperature range of a permission, rather than a temperature value accurately.(2) if initial temperature not in given preset temperature range, can carry out preheating or precooling treatment to surveyed area by instrument, but also can allow tester oneself indoorly simply wait for a period of time, detect again after waiting test section megadyne temperature degree to reach requirement by suitable means (as washing one's hands) or in that temperature is more constant with cold water or hot water.(3) produce the used electromagnetic mode difference of heating.Specifically, microwave generator no longer adopts magnetron and related circuit thereof, but adopts semiconductor device to produce microwave, and corresponding accessory is also just different.(4) temperature monitoring can also can adopt non-contacting infrared probe with the sensor probe that directly contacts skin.(5) same detector can have one with upper channel, and each passage is corresponding to different detection positions (as the left hand and the right hand) or different detection people.(6) by detected person's long periods of wear, but the monitor that self-timing detects and reports to the police.(7) form by a detection main frame and a plurality of detection extension set, can in one day 24 hours, monitor a plurality of patients' multichannel blood glucose monitoring system simultaneously.(8) detection head of employing horn mouth shape makes the microwave to the skin emission can concentrate on a pocket, thereby produces more significant heats with less output or microwave intensity.For reaching this purpose, bell-mouthed inner surface should evenly be smeared the material (as the spray metal thin layer) of one deck microwave reflection.Bell-mouthed inner surface configuration can be a taper seat, also can be other quadratic surface, as hyperboloid or parabola.(9) for reducing the interference of microwave emission to temperature sensor, the technology that adopts microwave emission and temperature detection to hocket.Such as within a second (1,000 millisecond), first 50 milliseconds of launched microwaves, not detected temperatures.Second 50 milliseconds are carried out temperature detection, stop the microwave emission.The 3rd 50 milliseconds begin launched microwave again ... the rest may be inferred.The shared time ratio of microwave and temperature detection can decide according to heats.It is remarkable inadequately to rise as the heating region temperature, illustrates that microwave is not enough launch time, can improve ratio.Such as becoming 2: 1, after promptly microwave is launched 100 milliseconds, 50 milliseconds of detected temperatures, and then launch 100 milliseconds, and the like.Generally speaking, the microwave emission can be from 1: 1 to 50: 1 with the proportion of shared time of temperature detection.
(4) description of drawings
Fig. 1 is the axonometric chart of the embodiment of the invention one box profile;
Fig. 2 is the internal structure sketch map of the embodiment of the invention one;
Fig. 3 is the structural representation of heating head;
Fig. 4 is that 21 kinds of the embodiment of the invention are worn on the non-wound rapid blood sugar monitor sketch map on the wrist;
Fig. 5 is the non-wound rapid blood sugar monitor sketch map of 31 kinds of network structures of the embodiment of the invention;
Fig. 6 is a computer and the sketch map that detects the host communication content among the embodiment three;
Fig. 7 is the main program block diagram of non-wound rapid blood sugar detecting method of the present invention.
Among the figure: 1-box-type shell, 2-heating head, 21-detect horn mouth, the central shaft of 22-heating head, 23-temperature sensing probe, 24-coaxial cable.
3-watchband, 4-watch style shell, 5-computer, 6-wiring, 7-detect main frame, 8-wire net, 9-wrist section.10-display screen, 11-on and off switch, 12-action button.
(5) specific embodiment
Embodiment one is referring to Fig. 1,2,3: this non-wound rapid blood sugar detector has a box-type shell 1, has at least one to detect horn mouth 21 on the surface of shell, and above-mentioned detection horn mouth inner wall shape is taper seat or quadratic surface, and inner wall surface scribbles a reflectance coating.Stretch out the central shaft 22 of a heating head in this detection horn mouth, the upper end of the central shaft of this heating head protrudes in case surface, and the lower end is connected with microwave generator in the shell through coaxial cable, and microwave generator adopts semiconductor device to produce microwave; Also have a display screen 10 above the shell, this display screen is connected with the data output end signal of central die in the shell; This shell also is connected with action button 12 with power interface, computer communication interface, on and off switch 11, detection display lamp.
A central die is arranged in the shell, this central die have in advance control sequence and respectively with dc source circuit unit, microwave power regulon, be used for monitoring temperature and to the temperature detection control unit of central die transmission variations in temperature eigenvalue, be used to be provided with and increase and decrease the thermostat unit of regulating preset temperature range, be used to adjust the time regulon of the length of microwave heating time; Above-mentioned dc source circuit unit also is connected with microwave generator, and above-mentioned dc source circuit unit is rechargeable battery or accumulator.Said temperature detects control unit and connects a temperature sensing probe, and this temperature sensing probe is positioned at the top of heating head, also is equipped with a cooling fan in the above-mentioned shell, and the air inlet of cooling fan has air stream outlet facing to microwave generator on the shell.
Central die can be bought common operating mode single-chip microcomputer and be finished whole required functions.Such as, adopting model is the single-chip microcomputer of 89S52, its dominant frequency is 24,000,000, can import the control sequence of 8K, and carries the A-D conversion.So-called temperature detection control unit can directly be bought chip temperature, also can oneself buy the material assembling.Such as, when adopting copper-constantan thermocouple (being easy on market, buy), to amplify earlier from the analogue signal (magnitude of voltage) that the probe that contacts skin spreads out of, carry out the A-D conversion again.Amplify and the digital translation part so temperature detection-control unit just mainly comprises, these all are conventional parts, and are readily available as commercial products.As adopt aforementioned 89S52 single-chip microcomputer, then the A-D conversion also can save, because of single-chip microcomputer has carried this function.Same LCDs also can directly be bought from the market.Such as, 128X128 graphic dot matrix Liquid Crystal Module is with Chinese and English character library, can show 8 row Chinese character or English, and built-in T6963C controller is arranged, and carries negative pressure and LED-backlit.The programming that can provide by aforementioned single-chip microcomputer, allow LCDs show required interface automatically, as blood glucose value, detection time and former blood sugar test data etc., also can artificially control other function, as access former blood sugar test data etc. by display screen control unit (or button).The preset temperature unit can have multiple mode to make, and the simplest is only to design several preset temperature shelves, as 25 ℃, 28 ℃ and 30 ℃, connects single-chip microcomputer with common Gear-shift switch or band switch and gets final product.The microwave power regulon also has multiple mode to realize.The simplest is to control input current with resistance, promptly realizes with variable resistance.Commercially available various time controllers are assembled on the microwave action time regulon available markets, also need to be connected with single-chip microcomputer.Cooling fan can adopt the common computer fan, and its switch time, same back able to programme was by Single-chip Controlling.Other part, as coaxial cable, on and off switch, protective tube, cabinet, computer communication interface, socket etc. all are easy to buy the back assembling.
Display screen: be used to show and detect the blood sugar concentration that obtains that detection time and in the past detected content such as data, it links to each other with data show control circuit in the central die.
External heat source: refer to the alternating electric field or the electromagnetic field of certain power and frequency, frequency can be from 50Hz～3 * 10
14Hz, wavelength can on actual the use, (be generally less than 3 * 10 from 6 * 106m～0.76 μ m when frequency is low
6Hz), need directly to contact with skin, make alternating current give birth to heat by tissue with electrode.When frequency is higher (＞3 * 10
14Hz), can contact or do not contact skin, and act on tissue in the mode of electromagnetic induction and electromagenetic wave radiation.At microwave band (from wavelength 1m to 1mm), this heat effect can produce significant heat effect, the variations in temperature feature of tissue and the concentration of blood glucose have positive correlation clearly. certainly, add the intensity of electromagenetic wave radiation, frequency and action time must be selected through careful, can not be subjected to temporary transient or nonvolatil injury to guarantee tissue.The power of external heat source depends on the thermal source type, action time, position, the zone of action and size, with factors such as contact skin mode and distance and patient individual differences. selection principle is tissue not to be produced under the condition of heat or other injury, select high slightly power, make living thermal effect remarkable as far as possible.
The required electric energy of external heat source can be from indoor alternating current power supply, also can be by supplying with from charged pool or accumulator; Comprise the semiconductor microactuator wave producer and, provide the thermal source at the detected position of heating by the generator power circuit that transformator and other electron component are formed.Here said " external heat source " is the heating that is different from human body self.
The present invention can adopt one or more external heat sources, to the one or more positions of human body, heat effect is carried out in the zone of a certain size of organ or tissue, adopt one or more temperature measuring devices to carry out the temperature dynamic monitoring in the aforementioned zone that is applied, the temperature data of measuring is carried out analyzing and processing, find out representative variation characteristic, with this basis that contrasts as the data that down adopt conventional blood sugar detecting method to obtain with equal conditions, thereby obtain the correlation curve or the conversion relation formula of variations in temperature feature and blood glucose.Make in utilization after this, can directly derive blood glucose value according to these curves or conversion relation formula by the variations in temperature feature that detection obtains.
Microwave power regulon: be used for regulating the input microwave intensity.
Temperature monitoring: be used for monitoring temperature and transmit the variations in temperature eigenvalue to central die, be located in the heating head horn mouth, temperature monitoring is selected the sensor probe of direct contact skin for use, when adopting the contact probe, probe end should not be lower than the horn mouth plane, the detection position of avoiding covering on the loudspeaker actinal surface does not reach probe, should make during design that probe head is vertical and be pressed in surface, tested position.
Temperature detection-control unit: be responsible for monitoring temperature and transmission temperature data.
Thermostat unit: be used for being provided with and increase and decrease adjusting preset temperature range.
Time regulon: the length that is used to adjust microwave heating time.
Coaxial cable: be used for Transmission Microwave, an end is connected with external heat source, and end is connected with heating head in addition.
Detect display lamp: when microwave generator starts, this lamp will glimmer, and point out formal detection to begin, and after detection was finished, this lamp extinguished automatically.
Computer interface: can realize data or communication for information between detector and the external computer by it.
Dc source circuit unit: being mainly used in provides required running voltage in each unit and electric current.
Cooling fan: its effect is to microwave generator and transformator cooling, in order to avoid higher device temperature influences testing result before detecting next time after one-time detection is finished.Wind inlet of fan is located at the cabinet sidewall, and fan airstream is over against microwave generator, and air stream outlet is located at the sidewall on air inlet opposite.
Referring to Fig. 3: heating head 2 is connected on the box-type shell 1, detection horn mouth 21 plane parallel are in box-type shell 1 and exceed box-type shell 1-10 millimeter, central shaft 22 1 ends of heating head directly connect coaxial cable 24, one end directly contacts skin, microwave is by central shaft 22 direct heating contact position skin and deep tissues, the central shaft 22 outer horn mouths that are with of heating head, its internal layer spray metal thin layer, the microwave of dispersing is concentrated in the small range, the outside diameter that detects horn mouth 21 is the 8-30 millimeter, and the inner surface configuration that detects horn mouth 21 is a taper seat.
Detecting horn mouth 21 manufacturing process is: cast out the plastics profile with mould earlier, then inner surface is added layer of metal film with spraying or plating mode; The central shaft 22 usefulness machining mode of heating head are finished, and material selects copper, detect horn mouth 21, and the central shaft 22 of heating head and the connected mode of coaxial cable 24 are to be threaded.
The microwave generator manufacturing that relates in this detector is not difficult, can buy part and material oneself assembling.The semiconductor device that produces microwave has multiple choices: (1) transistor oscillator: peak power output 20-300mW, and frequency range 1.5-3.5GHz, tuning characteristic: electricity accent/machine is transferred output form: coaxial cable, circuit structure: little band.(2) field effect agitator: peak power output 40-200mW, frequency range 4-6GHz, tuning characteristic: some frequency, output form: coaxial cable, circuit structure: little band.(3) bulk-effect oscillator (VTZ series): peak power output 50-5000mW, frequency range 4-10GHz, tuning characteristic: electricity accent/machine is transferred output form: coaxial cable, circuit structure: cylindrical cavity.(5) avalanche osccillator: peak power output 30-300mW, frequency range 8-10GHz, tuning characteristic: machine is transferred, output form: waveguide, circuit structure: cylindrical cavity.From watt level and control, transmission conveniently, first three is planted better.The best way is that requirement professional production producer is by suitable microwave generator and the required circuit of parameter (frequency and power) processing that oneself needs.
A kind of non-wound rapid blood sugar detecting method of using above-mentioned non-wound rapid blood sugar detector, it is as follows that it mainly detects step:
Step a: preset temperature range in the selected common shell temperature scope that preheats the zone, preestablishes detected person's per day shell temperature scope according to concrete patient;
Step b: preliminary examination, the detected person will detect position skin and be attached on the detection horn mouth, start back central die is sent instruction, make the temperature detection control unit begin initial temperature, temperature detection result is compared with the preset temperature range in being stored in chip, as surpassing this scope by the temperature sensing probe detection of skin, central die judges, temporarily will not detect, and show " wait " information on display screen, position to be detected temperature detects after reaching the requirement temperature range again;
Step c: the formal detection, after confirming that test section megadyne temperature degree has reached the preset temperature range of permission, central die is sent the instruction of formal detection, allow microwave generator by predefined power, frequency and action time begin to send microwave, simultaneously detect display lamp begin the flicker; The technology that adopts microwave emission and temperature detection to hocket, the central shaft that two kinds of shared time scale scopes of process are 1: 1 to 50: 1 microwave by coaxial cable and heating head is drawn towards the palm of the hand, by temperature detecting unit when beginning to heat or from a certain moment, surveyed area is begun to carry out temperature monitoring, finish or finish a certain moment of back up to heating and stop, and representative variations in temperature characteristic value data is transferred to central die stores;
Steps d: date processing, after microwave heating stops, the detection display lamp extinguishes, central die will be carried out analyzing and processing to the data of all storages, by preset program representative variations in temperature eigenvalue and memory information are made comparisons, correlation curve or conversion relation formula according to variations in temperature feature and blood glucose calculates blood glucose value simultaneously, and shows by LCDs; The present invention detects the blood glucose value that obtains and is meant the patient in a certain blood capillary full blood glucose value constantly that detects, and available mmol/L or mg/dL are unit representation.
Step e: the cooling instrument, after detection is finished, detect the position and leave the detection horn mouth, central die provides instruction, starts cooling fan, and blow air cooling instrument after cooling fan stops, being turned off on and off switch, waits for detection next time; The detected person accesses the testing result that is stored in to pass by in the central die in one period by the blood glucose level data in button investigation a period of time of seeing over or by computer interface, and unloading is in computer or to deliver to hospital for reference.
The said skin of the present invention comprises the organ and the tissue in any zone that has skin in all body surfaces.Said organ is meant ear, and extremity (comprising finger and toe) etc. are exposed to organ outer and that be easy to measure, and said " tissue " is meant the tissue that external heat sources such as outer skin, corium, veins beneath the skin can affact.The said zone of the present invention is meant aforementioned position, prepares to detect with external heat source heating back the zone of blood glucose in the organ or tissue, can be described as the desire heating region.For making homogeneous heating be convenient to temperature survey again, this zone should be not excessive.
The said temperature detecting unit of the present invention is meant can be by the contact conduction of heat, and convection current or non-contacting radiation mode correctly detect the instrument of external heat source zone of action variations in temperature.To its performance demands is that (1) precision is not less than 0.1 ℃.(2) short to the response time of variations in temperature, preferably be not more than 5 seconds.(3) detection probe is to detected temperature field influence as far as possible little (promptly Tan Tou thermal capacity should be the smaller the better).(4) reliable operation, volume with little for well.
The present invention comprises the removal of invalid data to the analyzing and processing of temperature data, and temperature is advanced the speed, maximum temperature, mean temperature, contents such as isoparametric extraction of maximum temperature persistent period and error analysis.
The present invention detects the representative variations in temperature eigenvalue that obtains and is meant rate temperature change, the maximum temperature after stopping to heat, maximum temperature retention time, the parameters such as temperature value in the heating a certain moment of back.
The present invention's said " correlation curve of variations in temperature feature and blood glucose or conversion relation formula " can be simple analytic formula, also can be complicated empirical equation, can also be curve form and other the similar mathematical relationship that is stored among the data base.The correlation curve of variations in temperature feature and blood glucose or conversion relation formula are given an example:
1, select on the time dependent curve of temperature near straight line, and the less paragraph of temperature fluctuation fluctuation.
2, determine the slope K of this paragraph.
3, calculate blood glucose value H by following conversion relation formula.
H＝aK2+bK+C
4, according to there being wound blood glucose comparison and detection value (carry out three have wound and noinvasive under equal conditions continuously and detect the contrast experiment) to determine coefficient a, b and c in the conversion relation formula.
Equal conditions when the said and conventional blood sugar detecting method of the present invention compares is meant same patient, at same or approaching detection position, and the detection that the while or the approaching as far as possible moment carry out.So-called " conventional blood sugar detecting method " is meant that the vein whole blood test (carrying out in hospital usually) that adopts glucose oxidase method or capillary tube whole blood test (be in usually and detected with small-sized blood-sugar detecting instrument by the patient) etc. are generally acknowledged the wound blood sugar detecting method more accurately.
Embodiment two is referring to Fig. 4: this non-wound rapid blood sugar detector has a watch style shell, and central die and warning circuit, clock unit and communication component signal link together.Outside work, working environment mobile big patient or instrument detected person, it is comparatively convenient to adopt rechargeable battery or accumulator to make power supply for for a long time.This kind watch style detector is that power supply is different with the main distinction of previous embodiment one.In fact, the direct current rechargeable battery that this machine adopts, its input voltage can change in the scope of 9-24V, and this class battery can have been bought on market easily.This watch style detector can be realized a machine three-use, promptly surveys blood glucose, time showing and mobile communication, detect finish after, be stored in the central die in the past the plurality of detection result in one period, can send to hospital or give the household for reference by cell-phone function.
This watch style detector is dwindling of above-mentioned instrument in shape, many monitoring facilitieses of timing automatic detection blood glucose on function.Owing to adopted the much smaller semiconductor device of volume to produce microwave, rather than, make reduced volume become possibility with the magnetron and the high-tension transformer of large volume.Simultaneously since the power consumption of semiconductor device much smaller than magnetron, so adopt miniature charging battery also can guarantee the power reguirements of instrument.In addition, because the watch style detector requires to be worn on for a long time on the wrist (or arm or other position), make heating head be permanently connected to skin, the initial temperature before each the detection is basic identical, thereby need not consider preset temperature range and corresponding preheating pre-cooling function.But need in central die, add (as 15 minutes or half an hour) heating detection automatically at set intervals, the alert program when preservation data and blood glucose are too high.This program is also uncomplicated, because general chip all has time clock feature, so can conveniently realize.Micro alarm has also been bought easily from the market.
This watch style detector adopts rechargeable battery or accumulator to make power supply, by wireless mode transmission data, adopts semiconductor device to produce microwave, is by detected person's long periods of wear, but the monitor that self-timing detects and reports to the police.This watch style detector has a shell with LCDs, watchband, mainly comprises in the shell: central die, microwave generator, heating head, battery unit, temperature detection control unit, battery unit and on and off switch.
A kind of non-wound rapid blood sugar detecting method of using above-mentioned non-wound rapid blood sugar detector, it is as follows mainly to detect step:
Step I, the detected person is worn to wrist with detector, and allowing the heating head and the temperature sensing probe that detect in the horn mouth be pressed on the wrist skin, the initial temperature before each the detection is basic identical, thereby need not consider initial temperature scope and corresponding preheating pre-cooling function;
Step II is started on and off switch, and central die is sent instruction, makes microwave generator send microwave, and simultaneous temperature sensor probe monitoring Heating Zone Temperature changes, and after testing result passes to central die, calculates and demonstrate blood glucose value, storage simultaneously or warning;
Step II I, after detection was finished, instrument stopped heating automatically, according to the default assay intervals time, reheats detection automatically;
Step IV, detect finish after, be stored in the central die in the past the testing result in one period, send to hospital or give the household for reference by cell-phone function.
Embodiment three is referring to Fig. 5,6,7: this non-wound rapid blood sugar detector connects the network structure that the detection extension set more than is formed by the detection main frame of a connection computer, the computer communication interface of every detection extension set through wire net with the detection main frame be connected with computer;
Computer: send monitored instruction, the viewing system working condition is retrieved for examination patient's blood glucose data and out of Memory, input preset temperature range, calculating parameter, conversion relation formula or curve.
Detect main frame and accept the instruction that regularly detected in a day 24 hours that the operator sends, and will instruct timed sending to detect extension set to each; Accept respectively to detect the detection data that extension set is sent; Analyzing and processing data calculates the blood glucose value that respectively detects the extension set detected person, and stores and demonstration; For the detection mistake that occurs for some reason, judgment data lost efficacy, and made mistakes from trend and detected extension set and send the instruction of resurveying, and data are reaffirmed analysis to resurveying; Detect the whether unusual situation of extension set detected person blood glucose value according to each, send alarm signal; According to different detected persons' situation, set up different preset temperature range and calculating parameter or conversion relation formula, calculate to make things convenient for blood glucose.
What be ready at any time respectively detects extension set in case accept to carry out the detection instruction that the detection main frame regularly sends, the microwave generator of start detection extension set immediately, by coaxial cable microwave is delivered to and to be worn on detected person's heating head on one's body, central shaft by heating head applies microwave to the skin and the subcutaneous tissue of contact position, monitor this regional temperature change dynamics simultaneously, automatically close microwave after detecting end, detect extension set and enter armed state once more; The temperature data that records is sent back computer in real time, for analyzing and processing; Each detects extension set and connects heating head by coaxial cable, is used for transmitting detecting the microwave that extension set sends, and heating head is fixed on the monitoring position of detecting the extension set detected person for a long time.
A kind of non-wound rapid blood sugar detecting method of using above-mentioned non-wound rapid blood sugar detector, mainly detect step referring to Fig. 7:
Step 3, N passage detect extension set and are ready to complete, and send " can detect " signal to detecting main frame;
After step 4, detection main frame receive that the N passage detects the extension set signal, pick up counting;
Step 9, detection main frame will be preserved data and the comparison of default blood glucose danger warning scope;
As do not exceed default blood glucose risk range, enter step 12;
After step 13, the warning, the N passage suspends detection, treats to restart after medical personnel handle, and gets back to step 2;
Step 14: after detection is finished, detect the position and leave horn mouth, central die provides instruction, starts cooling fan, and blow air cooling instrument after cooling fan stops, being turned off on and off switch, waits for detection next time; The detected person accesses the testing result that is stored in to pass by in the central die in one period by the blood glucose level data in button investigation a period of time of seeing over or by computer interface, and unloading is in computer or to deliver to hospital for reference.
The present invention can realize that temperature dynamic detects, before the external heat source effect initial temperature of desiring heating region is detected, as initial temperature not in preset temperature range, need under the help of temperature monitoring probe, surveyed area to be lowered the temperature or heat adjustment, perhaps allow tester oneself by suitable means (as movable health, rub with the hands and detect the position, detect position etc. with cold water or hot-water soak) or more constant indoor the waiting for a period of time of temperature, after test section megadyne temperature degree reaches the preset temperature range of permission, just begin to start the external heat source heating.Next, to this regional temperature monitoring can from when heating just, and last till that always heating stops or delaying a period of time again.The collection of temperature measuring data can be carried out automatically by programme-control.Interval between adjacent twice collection, total acquisition time, parameters such as preset temperature value can be imported in advance, also can adjust in program as the case may be.Here said preset temperature range is meant the common shell temperature scope at selected desire heating region according to concrete patient, a predefined per day shell temperature scope.Because shell temperature can be with sense environmental conditions, all multifactor changes such as detection time and season and changing are so before detecting beginning, the initial temperature of desiring heating region often has fluctuation, if fluctuation is little, still in the scope of permission 1, then can detect by direct heating.If fluctuation has exceeded preset temperature range, for obtaining result more accurately, need carry out sufficient preheating or pre-cooling, up to the temperature range that has really reached permission to this zone.
Claims (9)
1. non-wound rapid blood sugar detector, comprise a shell, it is characterized in that: have at least one to detect horn mouth in case surface, stretch out the central shaft of a heating head in this detection horn mouth, the upper end of the central shaft of this heating head protrudes in case surface, and the lower end is connected with microwave generator in the shell through coaxial cable; Also have a display screen above the shell, this display screen is connected with the data output end signal of central die in the shell; This shell also is connected with action button with power interface, computer communication interface, on and off switch, detection display lamp;
A central die is arranged in the shell, this central die has control sequence in advance and is connected with the temperature detection control unit with dc source circuit unit respectively, above-mentioned dc source circuit unit is connected with microwave generator, said temperature detects control unit and connects a temperature sensing probe, this temperature sensing probe is positioned at the top of heating head, also be equipped with a cooling fan in the above-mentioned shell, the air inlet of cooling fan has air stream outlet facing to microwave generator on the shell.
2. non-wound rapid blood sugar detector according to claim 1 is characterized in that: above-mentioned detection horn mouth inner wall shape is taper seat or quadratic surface, and inner wall surface scribbles a reflectance coating.
3. non-wound rapid blood sugar detector according to claim 1, it is characterized in that: above-mentioned shell is a box-type shell, central die respectively with the microwave power regulon, be used for monitoring temperature with to the temperature detection control unit of central die transmission variations in temperature eigenvalue, be used to be provided with the time regulon that increases and decreases the thermostat unit of regulating preset temperature range, be used to adjust the length of microwave heating time and be connected.
4. non-wound rapid blood sugar detector according to claim 1 is characterized in that: above-mentioned shell is the watch style shell, and central die links together with warning circuit, clock unit and communication component respectively.
5. non-wound rapid blood sugar detector according to claim 1, it is characterized in that: above-mentioned detector connects the network structure that the detection extension set more than is formed by the detection main frame of a connection computer, the computer communication interface of every detection extension set through wire net with the detection main frame be connected with computer;
Computer: send monitored instruction, the viewing system working condition is retrieved for examination patient's blood glucose data and out of Memory, input preset temperature range, calculating parameter, conversion relation formula or curve;
Detect main frame and accept the instruction that regularly detected in a day 24 hours that the operator sends, and will instruct timed sending to detect extension set to each; Accept respectively to detect the detection data that extension set is sent; Analyzing and processing data calculates the blood glucose value that respectively detects the extension set detected person, and stores and demonstration; For the detection mistake that occurs for some reason, judgment data lost efficacy, and made mistakes from trend and detected extension set and send the instruction of resurveying, and data are reaffirmed analysis to resurveying; Detect the whether unusual situation of extension set detected person blood glucose value according to each, send alarm signal; According to different detected persons' situation, set up different preset temperature range and calculating parameter or conversion relation formula, calculate to make things convenient for blood glucose;
What be ready at any time respectively detects extension set in case accept to carry out the detection instruction that the detection main frame regularly sends, the microwave generator of start detection extension set immediately, by coaxial cable microwave is delivered to and to be worn on detected person's heating head on one's body, central shaft by heating head applies microwave to the skin and the subcutaneous tissue of contact position, monitor this regional temperature change dynamics simultaneously, automatically close microwave after detecting end, detect extension set and enter armed state once more; The temperature data that records is sent back computer in real time, for analyzing and processing; Each detects extension set and connects heating head by coaxial cable, is used for transmitting detecting the microwave that extension set sends, and heating head is fixed on the monitoring position of detecting the extension set detected person for a long time.
6. an application rights requires the non-wound rapid blood sugar detecting method of any non-wound rapid blood sugar detector of 1-5, and it is as follows to it is characterized in that mainly detecting step:
Step a: preset temperature range in the selected common shell temperature scope that preheats the zone, preestablishes detected person's per day shell temperature scope according to concrete patient;
Step b: preliminary examination, the detected person will detect position skin and be attached on the detection horn mouth, start back central die is sent instruction, make the temperature detection control unit begin initial temperature, temperature detection result is compared with the preset temperature range in being stored in chip, as surpassing this scope by the temperature sensing probe detection of skin, central die judges, temporarily will not detect, and show " wait " information on display screen, position to be detected temperature detects after reaching the requirement temperature range again;
Step c: the formal detection, after confirming that test section megadyne temperature degree has reached the preset temperature range of permission, central die is sent the instruction of formal detection, allow microwave generator by predefined power, frequency and action time begin to send microwave, simultaneously detect display lamp begin the flicker; The technology that adopts microwave emission and temperature detection to hocket, the central shaft that two kinds of shared time scale scopes of process are 1: 1 to 50: 1 microwave by coaxial cable and heating head is drawn towards the palm of the hand, by temperature detecting unit when beginning to heat or from a certain moment, surveyed area is begun to carry out temperature monitoring, finish or finish a certain moment of back up to heating and stop, and representative variations in temperature characteristic value data is transferred to central die stores;
Steps d: date processing, after microwave heating stops, the detection display lamp extinguishes, central die will be carried out analyzing and processing to the data of all storages, by preset program representative variations in temperature eigenvalue and memory information are made comparisons, correlation curve or conversion relation formula according to variations in temperature feature and blood glucose calculates blood glucose value simultaneously, and shows by LCDs;
Step e: the cooling instrument, after detection is finished, detect the position and leave horn mouth, central die provides instruction, starts cooling fan, and blow air cooling instrument after cooling fan stops, being turned off on and off switch, waits for detection next time; The detected person accesses the testing result that is stored in to pass by in the central die in one period by the blood glucose level data in button investigation a period of time of seeing over or by computer interface, and unloading is in computer or to deliver to hospital for reference.
7. non-wound rapid blood sugar detecting method according to claim 6 is characterized in that: above-mentioned detection position skin comprises: have any zone of skin in all body surfaces or be exposed to the outer and human organ that is easy to measure or tissue that outer skin, corium, veins beneath the skin and other external heat source can affact.
8. an application rights requires the non-wound rapid blood sugar detecting method of 4 non-wound rapid blood sugar detector, and it is as follows to it is characterized in that mainly detecting step:
Step I, the detected person is worn to wrist with detector, and allowing the heating head and the temperature sensing probe that detect in the horn mouth be pressed on the wrist skin, the initial temperature before each the detection is basic identical, thereby need not consider initial temperature scope and corresponding preheating pre-cooling function;
Step II is started on and off switch, and central die is sent instruction, makes microwave generator send microwave, and simultaneous temperature sensor probe monitoring Heating Zone Temperature changes, and after testing result passes to central die, calculates and demonstrate blood glucose value, storage simultaneously or warning;
Step II I, after detection was finished, instrument stopped heating automatically, according to the default assay intervals time, reheats detection automatically;
Step IV, detect finish after, be stored in the central die in the past the testing result in one period, send to hospital or give the household for reference by cell-phone function.
9. an application rights requires the non-wound rapid blood sugar detecting method of 5 non-wound rapid blood sugar detector, and it is as follows to it is characterized in that mainly detecting step:
Step 1, detection host parameter are set: determine effective port number, monitoring time interval, blood glucose danger warning scope, type of alarm;
Step 2, N passage detect the extension set start and prepare;
Step 3, N passage detect extension set and are ready to complete, and send " can detect " signal to detecting main frame;
After step 4, detection main frame receive that the N passage detects the extension set signal, pick up counting;
Step 5, time reach default monitoring time at interval, detect main frame and send the beginning sense command to detecting extension set;
Step 6, N passage detect extension set and receive the beginning sense command, start microwave heating, begin to detect;
Step 7, N passage stop heating after detecting and dividing machine testing to finish automatically, detect data to detecting the main frame transmission;
Step 8, detection main frame detect data with this time and preserve;
Step 9, detection main frame will be preserved data and the comparison of default blood glucose danger warning scope;
Step 10, detection main frame determine whether to report to the police according to comparative result; As exceed default blood glucose risk range, enter step 11;
As do not exceed default blood glucose risk range, enter step 12
Step 11, blood glucose do not go beyond the scope, and step 5 is got back in reclocking immediately;
Step 12, report to the police with default type of alarm;
After step 13, the warning, the N passage suspends detection, treats to restart after medical personnel handle, and gets back to step 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200710200028XA CN100435729C (en) | 2007-01-08 | 2007-01-08 | Atraumatic quick-action blood-sugar measuring apparatus and application method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200710200028XA CN100435729C (en) | 2007-01-08 | 2007-01-08 | Atraumatic quick-action blood-sugar measuring apparatus and application method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN100998507A true CN100998507A (en) | 2007-07-18 |
| CN100435729C CN100435729C (en) | 2008-11-26 |
Family
ID=38257382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200710200028XA Active CN100435729C (en) | 2007-01-08 | 2007-01-08 | Atraumatic quick-action blood-sugar measuring apparatus and application method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100435729C (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596013A (en) * | 2009-09-18 | 2012-07-18 | 阿克伦大学 | Optical device and method for non-invasive real-time testing of blood sugar levels |
| CN103040441A (en) * | 2011-10-14 | 2013-04-17 | 无锡沃骐医疗科技有限公司 | Wrist type wireless monitoring system |
| CN103298399A (en) * | 2010-11-01 | 2013-09-11 | 加的夫大学学院咨询有限公司 | In-vivo monitoring with microwaves |
| CN103550843A (en) * | 2013-11-08 | 2014-02-05 | 上海移宇科技有限公司 | Skin heating type artificial pancreas |
| CN103549963A (en) * | 2013-11-08 | 2014-02-05 | 上海移宇科技有限公司 | Implanted real-time dynamic blood sugar monitoring equipment |
| CN105326481A (en) * | 2014-08-07 | 2016-02-17 | 何嘉健 | Non-invasive dynamic blood sugar concentration pre-warning system |
| CN106102366A (en) * | 2016-06-06 | 2016-11-09 | 合肥天地软件科技有限公司 | A kind of bus equipment sensing device |
| CN107951492A (en) * | 2017-11-16 | 2018-04-24 | 天津大学 | A kind of noninvasive dynamics monitoring device |
| CN108013866A (en) * | 2016-11-02 | 2018-05-11 | 北京大学 | A kind of new sign data detection method and wearable sign detection device |
| CN108553110A (en) * | 2018-04-12 | 2018-09-21 | 澳菲科技（深圳）有限公司 | Measure the method and its device of human blood components' content |
| CN108888243A (en) * | 2018-04-03 | 2018-11-27 | 中国人民解放军陆军军医大学第三附属医院（野战外科研究所） | A kind of medical 3D thermal infrared imager |
| CN109008989A (en) * | 2018-06-14 | 2018-12-18 | 杭州感到科技有限公司 | The measurement method and equipment of abdomen core temperature |
| CN109983341A (en) * | 2016-12-07 | 2019-07-05 | 雷迪奥米特医学公司 | System and method for estimating the temperature of liquid sample |
| CN110507331A (en) * | 2019-08-30 | 2019-11-29 | 上海海事大学 | A kind of invasive blood sugar measuring system based on ultrasonic velocity method |
| CN111938609A (en) * | 2020-07-03 | 2020-11-17 | 湖南优尼沃斯医疗科技有限公司 | Automatic blood vessel disease detection equipment |
-
2007
- 2007-01-08 CN CNB200710200028XA patent/CN100435729C/en active Active
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596013A (en) * | 2009-09-18 | 2012-07-18 | 阿克伦大学 | Optical device and method for non-invasive real-time testing of blood sugar levels |
| CN103298399A (en) * | 2010-11-01 | 2013-09-11 | 加的夫大学学院咨询有限公司 | In-vivo monitoring with microwaves |
| CN103040441A (en) * | 2011-10-14 | 2013-04-17 | 无锡沃骐医疗科技有限公司 | Wrist type wireless monitoring system |
| CN103550843A (en) * | 2013-11-08 | 2014-02-05 | 上海移宇科技有限公司 | Skin heating type artificial pancreas |
| CN103549963A (en) * | 2013-11-08 | 2014-02-05 | 上海移宇科技有限公司 | Implanted real-time dynamic blood sugar monitoring equipment |
| CN105326481A (en) * | 2014-08-07 | 2016-02-17 | 何嘉健 | Non-invasive dynamic blood sugar concentration pre-warning system |
| CN105326481B (en) * | 2014-08-07 | 2018-05-18 | 何嘉健 | A kind of hurtless measure dynamic glucose concentration early warning system |
| CN106102366A (en) * | 2016-06-06 | 2016-11-09 | 合肥天地软件科技有限公司 | A kind of bus equipment sensing device |
| CN108013866A (en) * | 2016-11-02 | 2018-05-11 | 北京大学 | A kind of new sign data detection method and wearable sign detection device |
| CN109983341A (en) * | 2016-12-07 | 2019-07-05 | 雷迪奥米特医学公司 | System and method for estimating the temperature of liquid sample |
| US11422107B2 (en) | 2016-12-07 | 2022-08-23 | Radiometer Medical Aps | System and method for estimating a temperature of a liquid sample |
| CN107951492A (en) * | 2017-11-16 | 2018-04-24 | 天津大学 | A kind of noninvasive dynamics monitoring device |
| CN108888243A (en) * | 2018-04-03 | 2018-11-27 | 中国人民解放军陆军军医大学第三附属医院（野战外科研究所） | A kind of medical 3D thermal infrared imager |
| CN108553110A (en) * | 2018-04-12 | 2018-09-21 | 澳菲科技（深圳）有限公司 | Measure the method and its device of human blood components' content |
| WO2019196733A1 (en) * | 2018-04-12 | 2019-10-17 | 澳菲科技（深圳）有限公司 | Method for measuring content of blood component of human body, and device therefor |
| CN109008989A (en) * | 2018-06-14 | 2018-12-18 | 杭州感到科技有限公司 | The measurement method and equipment of abdomen core temperature |
| CN110507331A (en) * | 2019-08-30 | 2019-11-29 | 上海海事大学 | A kind of invasive blood sugar measuring system based on ultrasonic velocity method |
| CN111938609A (en) * | 2020-07-03 | 2020-11-17 | 湖南优尼沃斯医疗科技有限公司 | Automatic blood vessel disease detection equipment |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100435729C (en) | 2008-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100435729C (en) | Atraumatic quick-action blood-sugar measuring apparatus and application method thereof | |
| CN101194838B (en) | Non-invasive blood sugar detecting instrument | |
| JP2017501847A (en) | Method and apparatus for biological evaluation | |
| CN105125134A (en) | Physical sign monitoring toilet seat based on Internet of Things | |
| WO2009100432A2 (en) | Whole body infrared thermography systems and methods | |
| CN104523244B (en) | Wearable-type electronic device and control method based on human body metabolism | |
| CN210073337U (en) | Intelligent health management system | |
| CN109875510A (en) | A kind of Multifunctional anesthesia section anesthesia depth monitor | |
| CN112472042A (en) | Wearable human body characteristic acquisition device, detection device and detection underwear | |
| CN106343973B (en) | Human body sign detection device | |
| CN106388995A (en) | Intelligent cooling patch | |
| US20190328237A1 (en) | Device and method for monitoring skin temperature and conductance | |
| CN106774526B (en) | Intelligent quilt and sheet system | |
| CN102641209A (en) | Electrocautery therapeutic instrument | |
| CN208780361U (en) | A kind of intelligent gateway with infrared human body thermometric and warning function | |
| CN206687813U (en) | A kind of intelligence is defervescence plaster used | |
| CN205795662U (en) | A kind of animal heat detection device | |
| CN214284891U (en) | Bra composed of multiple flexible sensors for breast cancer monitoring | |
| CN108051115A (en) | A kind of clinical thermometer | |
| CN107422757A (en) | Intelligent quilt and sheet system | |
| CN208540753U (en) | A kind of brassiere of multiple spot monitoring human chest temperature | |
| CN209499713U (en) | Multi-parameter monitor | |
| CN204838759U (en) | Intelligence sleep detects water pad that adjusts temperature | |
| CN215961813U (en) | Physical sign detection system based on whole-body thermotherapy | |
| CN111000534A (en) | Wearable multifunctional human body surface temperature and humidity monitoring equipment and early warning method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160214 Address after: 101111 Beijing City, Daxing District branch of Beijing economic and Technological Development Zone, fourteen Street No. 99 building 33 room 508 building B Patentee after: Beijing Galaxy boat Technology Co., Ltd. Address before: 100021 Beijing city Chaoyang District East sanhuan Road No. 19 Lai Yuen Ka B 15D6 Patentee before: He Zongyan |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20180418 Address after: 225312 C1, building 1613 and 1615, No. 1, Yao Cheng Road, Jiangsu (Taizhou Road, south side of the city road). Patentee after: Jiangsu sugar three medical technology Co Ltd Address before: 101111 Beijing City, Daxing District branch of Beijing economic and Technological Development Zone, fourteen Street No. 99 building 33 room 508 building B Patentee before: Beijing Galaxy boat Technology Co., Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180712 Address after: 100176 room 33, block B, 99 Chuang fourteen street, Beijing economic and Technological Development Zone, 508. Patentee after: Beijing Galaxy boat Technology Co., Ltd. Address before: 225312 C1, building 1613 and 1615, No. 1, Yao Cheng Road, Jiangsu (Taizhou Road, south side of the city road). Patentee before: Jiangsu sugar three medical technology Co Ltd |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180917 Address after: 213159 Jiangsu Changzhou West Taihu science and technology industry director Yang Road 9 Patentee after: Jiangsu Jing CE Medical Technology Co., Ltd. Address before: 100176 room 33, block B, 99 Chuang fourteen street, Beijing economic and Technological Development Zone, 508. Patentee before: Beijing Galaxy boat Technology Co., Ltd. |
|
| TR01 | Transfer of patent right |