CN103550843A - Skin heating type artificial pancreas - Google Patents
Skin heating type artificial pancreas Download PDFInfo
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- CN103550843A CN103550843A CN201310552894.0A CN201310552894A CN103550843A CN 103550843 A CN103550843 A CN 103550843A CN 201310552894 A CN201310552894 A CN 201310552894A CN 103550843 A CN103550843 A CN 103550843A
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Abstract
The invention provides a skin heating type artificial pancreas which comprises a blood sugar monitoring device, a duct-less insulin pump and a skin heating device, wherein the blood sugar monitoring device is used for monitoring the change of the blood sugar in a human body in real time and outputting a blood sugar value; the blood sugar monitoring device comprises a glucose sensor; the duct-less insulin pump is used for simulating the mode and function of a human pancreas for physiologically secreting insulin; the duct-less insulin pump comprises an insulin reserving hose; the skin heating device is used for heating the skin tissues located in the positions buried with the glucose sensor and/or the insulin reserving hose; and the skin heating device comprises a skin heating film, a temperature rising module, a temperature control module, a heat-insulating module and a temperature detecting module. The skin heating type artificial pancreas provided by the invention is capable of controlling the temperature of the skin of the human body, solving the delay problem between target blood sugar concentration and insulin peak acting time, shortening the insulin peak acting time and reducing the influence on the blood sugar monitoring caused by the temperature change.
Description
Technical field
The invention belongs to medicine instrument field, relate to a kind of artificial pancreas, particularly relate to a kind of skin hot type artificial pancreas.
Background technology
Pancreas in normal person's health can be monitored the variation of the glucose content in blood of human body automatically, and automatically secrete required insulin, and in diabetics body, cannot normally secrete needed by human body insulin, there is unusual condition in human pancreas's function, therefore diabetes are that metabolism class disease abnormal and that cause appears in human pancreas's function, and diabetes are lifelong disease.Medical skill there is no method radical cure diabetes at present, can only control by stabilizing blood sugar generation and the development of diabetes and complication thereof.
Current medical skill is by the hypodermic glucose sensor of implant into body, and the device can real-time dynamic monitoring blood sugar for human body changing is " Real-time and Dynamic blood glucose monitoring system "; By the hypodermic indwelling flexible pipe of implant into body, can the continuous 24 hours devices to the accurate infusion of insulin of subcutis be " insulin pump ".Traditional insulin pump needs external one section of conduit to connect the insulin pump pump housing and keeps somewhere flexible pipe, and this external conduit easily causes stopping up, breaking or leak; Novel " duct free insulin pump " specially refers to the built-in indwelling flexible pipe of the pump housing, and without the insulin pump of external conduit, the pump housing is directly attached to human body skin surface.Can real-time dynamic monitoring blood sugar for human body change, and to realize the continuous 24 hours devices to the accurate infusion of insulin of subcutis be " artificial pancreas " simultaneously.
Due to the very big peak action time that affect insulin of temperature meeting on human body skin surface, the peak of insulin is longer action time, insulin is just poorer to the real-time regulatory function of human blood glucose concentration, the surface temperature of human body skin is conventionally between 32-37 degree, in this temperature range, the peak of insulin is longer action time, the lower time of temperature is longer, traditional artificial pancreas system cannot solve target blood glucose concentration and the insulin peak delay issue between action time at present, therefore cannot realize regulating rapidly in real time of human blood glucose concentration.Blood sugar test principle is mostly enzymology electrode method at present, and the reaction relevant with enzyme is all subject to the impact of temperature in every case, and the surface temperature of human body skin can be subject to external environment and internal environment affects and fluctuates, and this is disadvantageous for blood sugar test.
Resistance heating film is emerging in recent years a kind of heating, the plane heater element being comprised of electrically insulating material and encapsulation heating resistor material within it.Resistance heating film, as a kind of novel low-temp radiating electrical heating elements, possesses following advantages:
1) high, the radiant heat accounting of electric conversion efficiency reaches;
2) electromagnetic radiation is little, to human body without harm;
3) efficient heat generation area is large, and thermal uniformity and thermal comfort are good;
4) stable physical property, power changes little, long service life;
5) thin thickness, the advantage such as take up room little.
Resistance heating film, as the electrical heating elements that can be directly heat energy by electric energy conversion after switching on, is added the personal characteristics of utilizing some heating film, also has development space large, the advantage that product applications is wide.
Summary of the invention
The shortcoming of prior art in view of the above, the object of the present invention is to provide a kind of skin hot type artificial pancreas, there is delay and reduces the problem that variations in temperature exerts an influence to Monitoring Blood Glucose in temperature solution target blood glucose concentration and the insulin peak of for solving prior art, controlling human body skin between action time.
For achieving the above object and other relevant objects, the invention provides a kind of skin hot type artificial pancreas, described artificial pancreas comprises: for the variation of Real-Time Monitoring blood in human body in sugar, and the blood sugar monitoring equipment of output blood glucose value; Described blood sugar monitoring equipment comprises glucose sensor and Dynamic Blood Glucose Monitoring device; For simulating the duct free insulin pump of pattern and the function of human pancreas's physiology excreting insulin; Described duct free insulin pump comprises drug storage unit, administration control unit, administration driver element and insulin indwelling unit, and described insulin is kept somewhere unit and comprised insulin indwelling flexible pipe; For heating, plant and bury described glucose sensor place, and/or plant and bury the skin heater that described insulin is kept somewhere hose skin histology, described skin heater comprises: skin heating film; Be built in described skin heating film, for heating, plant and bury described glucose sensor place, and/or plant and bury the intensification module that described insulin is kept somewhere hose skin histology; Be built in and be connected with described intensification module in described skin heating film, for regulating heating parameters to control the temperature control modules of heated perimeter; Be built in and be connected with described temperature control modules in described skin heating film, for keeping the heat preservation module of described skin histology temperature.
Preferably, described skin heater also comprises the temperature detecting module for detection of described skin histology temperature, and described temperature detecting module is built in described skin heating film or is placed in outside described skin heating film; While being built in described skin heating film, described temperature detecting module is connected with described temperature control modules.
Preferably, described glucose sensor and described insulin indwelling flexible pipe are planted and are embedded in same subcutaneous tissue place, and described skin hot type artificial pancreas only needs a skin heater; Described glucose sensor and described insulin indwelling flexible pipe are planted and are embedded in different subcutaneous tissue place, and described skin hot type artificial pancreas needs one or two skin heater.
Preferably, the power supply mode of described skin heater comprises: on described skin heating film, place the mutual inductor that can receive wireless power; Or described skin heating film is connected on the built-in power of described duct free insulin pump or described blood sugar monitoring equipment by wire.
Preferably, the power supply mode of described skin heater also comprises described skin heating film is connected to external power source by wire.
Preferably, described skin heating film is resistance heating film.
Preferably, the electrically insulating material of described resistance heating film is flexible material or rigid material.
Preferably, the heating temp of described skin heater is controlled between 32 degrees Celsius to 45 degrees Celsius.
Preferably, described duct free insulin pump is by wireless mode or wired mode and described blood sugar monitoring equipment connection.
As mentioned above, skin hot type artificial pancreas of the present invention, has following beneficial effect:
1, the temperature of controlling human body skin solves target blood glucose concentration and the delay issue of insulin peak between action time, has shortened insulin peak action time;
2, reduce skin temperature and change the impact on blood sugar monitoring.
Accompanying drawing explanation
Fig. 1 a is shown as the schematic diagram of skin heater theory structure of the present invention.
Fig. 1 b is shown as the schematic diagram of skin heater theory structure of the present invention.
Fig. 2 a is shown as the schematic diagram of skin heater structure of the present invention.
Fig. 2 b is shown as the schematic diagram of skin heater structure of the present invention.
Fig. 3 a is shown as the theory structure schematic diagram of skin hot type artificial pancreas of the present invention.
Fig. 3 b is shown as the theory structure schematic diagram of skin hot type artificial pancreas of the present invention.
Fig. 4 is shown as the theory structure schematic diagram of blood sugar monitoring equipment in skin hot type artificial pancreas of the present invention.
Fig. 5 is shown as duct free insulin pump theory structure schematic diagram in skin hot type artificial pancreas of the present invention.
Fig. 6 is shown as another duct free insulin pump structural representation in skin hot type artificial pancreas of the present invention.
Fig. 7 a is shown as the theory structure schematic diagram of the first skin heater in skin hot type artificial pancreas of the present invention.
Fig. 7 b is shown as the theory structure schematic diagram of the first skin heater in skin hot type artificial pancreas of the present invention.
Fig. 8 a is shown as the theory structure schematic diagram of Second Skin heater in skin hot type artificial pancreas of the present invention.
Fig. 8 b is shown as the theory structure schematic diagram of Second Skin heater in skin hot type artificial pancreas of the present invention.
Fig. 9 a is shown as the structural representation that in skin hot type artificial pancreas of the present invention, the first skin heater is powered by wireless power mutual inductor.
Fig. 9 b is shown as the structural representation that in skin hot type artificial pancreas of the present invention, the first skin heater is powered by wireless power mutual inductor.
Figure 10 a is shown as the first skin heater in skin hot type artificial pancreas of the present invention and passes through the structural representation of blood sugar monitoring device interior Power supply.
Figure 10 b is shown as the first skin heater in skin hot type artificial pancreas of the present invention and passes through the structural representation of blood sugar monitoring device interior Power supply.
Figure 11 a is shown as in skin hot type artificial pancreas of the present invention the first skin heater by the structural representation of external power source.
Figure 11 b is shown as in skin hot type artificial pancreas of the present invention the first skin heater by the structural representation of external power source.
Figure 12 a is shown as the structural representation that in skin hot type artificial pancreas of the present invention, Second Skin heater is powered by wireless power mutual inductor.
Figure 12 b is shown as the structural representation that in skin hot type artificial pancreas of the present invention, Second Skin heater is powered by wireless power mutual inductor.
Figure 13 a is shown as the structural representation that in skin hot type artificial pancreas of the present invention, Second Skin heater is powered by duct free insulin pump internal electric source.
Figure 13 b is shown as the structural representation that in skin hot type artificial pancreas of the present invention, Second Skin heater is powered by duct free insulin pump internal electric source.
Figure 14 a is shown as in skin hot type artificial pancreas of the present invention Second Skin heater by the structural representation of external power source.
Figure 14 b is shown as in skin hot type artificial pancreas of the present invention Second Skin heater by the structural representation of external power source.
Element numbers explanation
| 1 | |
35 | The |
| 11 | |
36 | |
| 12 | |
4 | The |
| 13 | |
41 | The first |
| 14 | |
42 | The |
| 15 | |
43 | The first |
| 2 | Blood |
44 | The first |
| 21 | |
45 | The first |
| 22 | Dynamic Blood |
5 | |
| 3 | Duct |
51 | Second |
| 31 | |
52 | The second intensification module |
| 32 | |
53 | The second |
| 33 | |
54 | The second |
| 34 | Insulin is kept somewhere |
55 | The second |
| 341 | Insulin is kept somewhere flexible pipe | ? | ? |
The specific embodiment
Below, by specific instantiation explanation embodiments of the present invention, those skilled in the art can understand other advantages of the present invention and effect easily by the disclosed content of this description.The present invention can also be implemented or be applied by the other different specific embodiment, and the every details in this description also can be based on different viewpoints and application, carries out various modifications or change not deviating under spirit of the present invention.
Refer to accompanying drawing.It should be noted that, the diagram providing in the present embodiment only illustrates basic conception of the present invention in a schematic way, satisfy and only show with assembly relevant in the present invention in graphic but not component count, shape and size drafting while implementing according to reality, during its actual enforcement, kenel, quantity and the ratio of each assembly can be a kind of random change, and its assembly layout kenel also may be more complicated.
Below in conjunction with embodiment and accompanying drawing, the present invention is described in detail.
Embodiment mono-
The present embodiment provides a kind of skin heater, is applied in the artificial pancreas being comprised of duct free insulin pump and blood sugar monitoring equipment.Refer to Fig. 1 a and Fig. 1 b, be shown as the theory structure schematic diagram of described skin heater, skin heater 1 comprises: skin heating film 11, intensification module 12, temperature control modules 13, heat preservation module 14 and temperature detecting module 15.
In the present embodiment, in described skin heater, skin heating film 11 adopts resistance heating film, and the power supply mode of described resistance heating film comprises it being to place the mutual inductor of wireless power on resistance heating film, be that the described mutual inductor for wireless power is used to the power supply of resistance heating film wireless type, resistance heating film is wired on the built-in power of described blood sugar monitoring equipment and duct free insulin pump, or described resistance heating film is connected on external power source by wire.The heating-up temperature of described skin heater need be controlled between 32～45 degrees Celsius; Described resistance heating film can be any shape, and for example, circle, ellipse, annular, triangle, U-shaped, Y shape or other is irregularly shaped, adopt circular in the present embodiment; And the electrically insulating material of resistance heating film can be flexible material, can be also rigid material, the present embodiment adopts flexible material.
Described intensification module 12 is built in described skin heating film 11, for heated skin tissue; In the present embodiment, described intensification module 12 is the integrated circuit that is rapidly heated, and the integrated circuit that is rapidly heated can be by heater element, the compositions such as power supply, temperature sampling element, switch element.
Described temperature control modules 13 is built in described skin heating film 11 and is connected with described intensification module, for regulating heating parameters to control heated perimeter; In the present embodiment, described temperature control modules 13 is a temperature-control circuit, and this temperature-control circuit can be comprised of temperature sensor, relay, temperature regulation circuit etc., and the temperature of skin histology is controlled between 32～45 degrees Celsius.
Described heat preservation module 14 is built in described skin heating film 11 and is connected with described temperature control modules, for keeping described skin histology temperature.In the present embodiment, heat preservation module 14 is a thermal circuit, in this circuit by Temperature Setting between 32～45 degrees Celsius, therefore, described thermal circuit can be comprised of temperature sensor, operational amplifier, comparator, heating module etc.
Described temperature detecting module 15 is for detection of described skin histology temperature.In the present embodiment, described temperature detecting module 15 is a temperature sensing circuit, and this circuit can be comprised of temperature sensor, single-chip microcomputer, temperature sensing circuit etc.Described temperature detecting module, can be built in described skin heating film 11, also can be placed on outside described skin heating film 11; When described temperature detecting module is built in described skin heating film 11, described temperature detecting module 15 is connected with described temperature control modules 13.Refer to Fig. 2 a and Fig. 2 b, be shown as the structural representation of described skin heater.
Embodiment bis-
The present embodiment provides a kind of skin hot type artificial pancreas, refer to Fig. 3 a and Fig. 3 b, be shown as the principle assumption diagram of described artificial pancreas, described skin hot type artificial pancreas comprises: blood sugar monitoring equipment 2, duct free insulin pump 3, the first skin heater 4 and Second Skin heater 5.
Blood sugar monitoring equipment 2, for the situation of change of Real-Time Monitoring and measurement blood in human body in sugar, the blood glucose value of monitoring human, and export the blood glucose value monitoring; Make like this patient and nursing staff can grasp at any time the change conditions of blood sugar for human body value, make counter-measure at this point.Refer to Fig. 4, be shown as the principle assumption diagram of described blood sugar monitoring equipment 2, described blood sugar monitoring equipment 2 comprises: glucose sensor 21 and Dynamic Blood Glucose Monitoring device 22.
Glucose sensor 21, for the variation of Real-Time Monitoring blood in human body in sugar, changes and produces blood glucose available signal according to blood in human body in sugar, output blood glucose available signal.Glucose sensor can be comprised of enzyme membrane and Clark oxygen electrode or hydrogen peroxide electrode.Can there is oxidation reaction in glucose, consume oxygen under the catalytic action of glucoseoxidase, generates gluconic acid lactone and hydrogen peroxide.Glucoseoxidase is fixed on the surface of close platinum electrode by the method for physical absorption by semipermeable membrane, its activity depends on its oxygen concentration around.Glucose and glucose oxidase enzyme reaction, generate two electronics and two protons.The reduction-state glucoseoxidase being surrounded by oxygen and electronics proton after reaction, Hydrogen Peroxide and oxidation state glucoseoxidase, glucoseoxidase get back to initial state and can with more glucose response.Concentration of glucose is higher, and the oxygen of consumption is more, and the hydrogen peroxide of generation is more.Concentration of glucose is lower, contrary.Therefore, the consumption of oxygen and the generation of hydrogen peroxide can be detected by platinum electrode, and can be used as the method for measuring glucose.Described glucose sensor 21 is implant into body subcutaneous tissue when measuring blood sugar for human body.Glucose sensor described in the present embodiment can be not only electrode sensor, and also Fibre Optical Sensor, such as usining fluorescence intensity as detection signal.
The Dynamic Blood Glucose Monitoring device 22 being connected with described glucose sensor 21 is for the treatment of the blood glucose available signal of described glucose sensor 21 outputs, and described blood glucose available signal is converted to blood glucose value,
Duct free insulin pump 3, refers to Fig. 5, is shown as duct free insulin pump theory structure, and described duct free insulin pump, for simulating pattern and the function of human pancreas's physiology excreting insulin, makes blood glucose obtain control continuous, that more meet psychological need.Described duct free insulin pump 3 obtains blood glucose value according to blood sugar monitoring equipment 2 or other modes, then calculates according to blood glucose value the optimal dose that human body needs insulin, by the injection of insulin that calculates optimal dose in human body.Wherein, described duct free insulin pump 3 comprises: drug storage unit 31, administration control unit 32, administration driver element 33 and insulin are kept somewhere unit 34.Described insulin is kept somewhere unit 34 and is comprised insulin indwelling flexible pipe 341.
The administration control unit 32 being connected with described drug storage unit 31 is for controlling the input of insulin; The activity that administration control unit management drug storage unit, administration driver element and insulin are kept somewhere unit.
The administration driver element 33 being connected with administration control unit 32 with described drug storage unit 31 is respectively for pushing insulin to human body according to the insulin optimal dose calculating; And
Be connected with described drug storage unit 31 with described administration control unit 32 respectively, comprise that the insulin of insulin indwelling flexible pipe 341 is kept somewhere unit 34 for the insulin indwelling flexible pipe 341 of the insulin of carrying described drug storage unit 31 to store is planted and is embedded in subcutis.
In the present embodiment, refer to Fig. 6, be shown as another duct free insulin pump structure, described duct free insulin pump can also comprise: comprise the insulin pump housing 35 and insulin controller 36: wherein, the described insulin pump housing 35 comprises: drug storage unit, administration driver element and insulin are kept somewhere unit.Described insulin is kept somewhere unit and is comprised insulin indwelling flexible pipe.
Drug storage unit is used for storing insulin;
The administration driver element being connected with drug storage unit is for being delivered to human body a part subcutaneous tissue by the insulin of described drug storage unit;
The insulin being connected with described drug storage unit is kept somewhere unit for the insulin indwelling flexible pipe of the insulin of carrying described drug storage unit to store is planted and is embedded in subcutis;
Described insulin controller 36 is connected with the described insulin pump housing 35, for managing a series of activities of the insulin pump housing 35.
The first skin heater 4, plants and buries described glucose sensor place skin histology for heating.Described the first skin heater 4 can be integrated on described blood sugar monitoring equipment 2, sticks on the surface of planting the skin histology that buries described glucose sensor; Or described skin heater is not integrated on described blood sugar monitoring equipment independent.Described the first skin heater 4 produces the temperature required impact of variations in temperature on blood sugar monitoring that reduce afterwards in energising.Refer to Fig. 7 a and Fig. 7 b, be shown as the theory structure of the first skin heater, described the first skin heater 4 comprises: the first skin heating film 41, the first intensification module 42, the first temperature control modules 43, the first heat preservation module 44 and the first temperature detecting module 45.
The first skin heating film 41;
Be built in the first intensification module 42 in described the first skin heating film 41 for heating between skin to 32～45 degree Celsius of implanting glucose sensor place; In the present embodiment, described the first intensification module 42 is the integrated circuit that is rapidly heated, and the integrated circuit that is rapidly heated can be comprised of heater element, power supply, temperature sampling element, switch element etc.
What be connected with described the first intensification module 42 is built in the first temperature control modules 43 in described the first skin heating film 41 for regulating heating parameters to control heated perimeter; In the present embodiment, described the first temperature control modules 43 is a temperature-control circuit, and this temperature-control circuit can be comprised of temperature sensor, relay, temperature regulation circuit etc., and the temperature of skin histology is controlled between 32～45 degrees Celsius.
That be connected with described temperature control modules 43, be built in the first heat preservation module 44 in described the first skin heating film 41 for the temperature of implanting described glucose sensor place skin histology is remained between 32～45 degrees Celsius; In the present embodiment, heat preservation module 44 is a thermal circuit, in this circuit by Temperature Setting between 32～45 degrees Celsius, therefore, described the first thermal circuit can be comprised of temperature sensor, operational amplifier, comparator, heating module etc.
The first intensification module 42, the first temperature control modules 43, the first heat preservation module 44 and the first temperature detecting module 45 can be built in the present embodiment and in the first skin heating film 41, form the first skin heater 4, now, described the first temperature detecting module 45 is connected with described the first temperature control modules 43.Or the first intensification module 42, the first temperature control modules 43 and the first heat preservation module 44 can be built in the first skin heating film 41 in the present embodiment, described the first temperature detecting module 45 is connected to form to the first skin heater 4 with described the first skin heating film 41.
Second Skin heating film 51;
The second intensification module 52 is built in described Second Skin heating film 51, for heating, plants and buries described insulin indwelling hose skin histology; In the present embodiment, described the second intensification module 52 is the integrated circuit that is rapidly heated, and the integrated circuit that is rapidly heated is comprised of heater element, power supply, temperature sampling element, switch element etc.
The second temperature control modules 53 is built in described skin heating film 51 and is connected 52 with described intensification module, for regulating heating parameters to control heated perimeter; In the present embodiment, described the second temperature control modules 53 is a temperature-control circuit, and this temperature-control circuit can be comprised of temperature sensor, relay, temperature regulation circuit etc., and the temperature of skin histology is controlled between 32～45 degrees Celsius.
The second heat preservation module 54 is built in described Second Skin heating film 51 and is connected with described the second temperature control modules 53, for maintenance, plants and buries described insulin indwelling hose skin histology temperature.In the present embodiment, heat preservation module 54 is a thermal circuit, in this circuit by Temperature Setting between 32～45 degrees Celsius, therefore, described the second thermal circuit 54 can be comprised of temperature sensor, operational amplifier, comparator, heating module etc.
The second temperature detecting module 55 buries for detection of planting the temperature that described insulin is kept somewhere hose skin histology.In the present embodiment, described temperature detecting module 55 is a temperature sensing circuit, and this circuit can be comprised of temperature sensor, single-chip microcomputer, temperature sensing circuit etc.
The second intensification module 52, the second temperature control modules 53, the second heat preservation module 54 and the second temperature detecting module 55 can be built in the present embodiment and in Second Skin heating film 51, form Second Skin heater 5, now, described the second temperature detecting module 55 is connected with described the second temperature control modules 53.Or the second intensification module 52, the second temperature control modules 53 and the second heat preservation module 54 can be built in Second Skin heating film 51 in the present embodiment, described the second temperature detecting module 55 is connected to form to Second Skin heater 5 with described Second Skin heating film 51.
Described Second Skin heater 5 can be integrated on described duct free insulin pump 3 and push insulin place skin histology for heating described duct free insulin pump 3; Or described Second Skin heater 5 is not integrated on described duct free insulin pump 3, and independent.Described Second Skin heater 5 has shortened the peak action time of insulin after energising is generated heat afterwards, is conducive to control faster blood glucose, thereby has realized regulating rapidly in real time of human blood glucose concentration.
Described in the present embodiment, in the first skin heater 4 and Second Skin heater 5, the first skin heating film 41 and Second Skin heating film 51 all can adopt resistance heating film, when described the first skin heater 4 is integrated on blood sugar monitoring equipment 2 and when Second Skin heater 5 is integrated on duct free insulin pump 3, the power supply mode of described resistance heating film is by place the mutual inductor of wireless power on resistance heating film, and the described wireless power mutual inductor that supplies is used to the power supply of resistance heating film wireless type.Or by being wired to, resistance heating film on the built-in power of described blood sugar monitoring equipment 2 and described duct free insulin pump 3, realizes power supply; When described the first skin heater 4 and Second Skin heater 5 independent, while not being integrated on blood sugar monitoring equipment 2 and duct free insulin pump 3, the power supply mode of described resistance heating film is by wire, resistance heating film to be connected on external power source.Refer to Fig. 9 a, Fig. 9 b, Figure 10 a, Figure 10 b, Figure 11 a, Figure 11 b, be shown as respectively the first skin heater 4 by the mutual inductor power supply of wireless power, by the 2 internal electric source power supplies of blood sugar monitoring equipment, by the structure chart of external power source.Refer to Figure 12 a, Figure 12 b, Figure 13 a, Figure 13 b, Figure 14 a and Figure 14 b, be shown as respectively Second Skin heater 5 by the power supply of wireless power mutual inductor, by described duct free insulin pump 3 internal electric source power supplies, by the structure chart of external power source.The heating-up temperature of described the first and second skin heaters need be controlled between 32～45 degrees Celsius; Described resistance heating film can be any shape, and for example, circle, ellipse, annular, triangle, U-shaped, Y shape or other is irregularly shaped, be circle in preferred situation; And the electrically insulating material of resistance heating film can be flexible material, can be also rigid material, under preferable case, be flexible material.
In the present embodiment, the structure of described skin hot type artificial pancreas can also be: described the first skin heater 4 can be integrated on blood sugar monitoring equipment 2, and described Second Skin heater 5 can not be integrated on duct free insulin pump 3; Or described the first skin heater 4 in described skin hot type artificial pancreas can not be integrated on blood sugar monitoring equipment 2, and described Second Skin heater 5 can be integrated on duct free insulin pump 3.
Skin hot type artificial pancreas of the present invention is by the infusion of worked in coordination between blood sugar monitoring equipment, duct free insulin pump, the first skin heater, Second Skin heater blood sugar monitoring and insulin, in this process, the temperature that can control human body skin to the heating of skin by the first skin heater, Second Skin heater solves target blood glucose concentration and the delay issue of insulin peak between action time, and reduces the impact of variations in temperature on blood sugar monitoring.
It is described above in detail that to be glucose sensor keep somewhere flexible pipe with insulin plants and adopt two skin heaters, i.e. the first and second skin heaters while being embedded in the different subcutaneous tissue of human body.When glucose sensor and insulin, keeping somewhere flexible pipe plants while being embedded in identical subcutis, just adopt a skin heater, now, skin heater both can be used as and had shortened the insulin peak electro-heat equipment of action time, also can be used as the electro-heat equipment of blood sugar monitoring, thereby realize the delay between action time of human blood glucose concentration and insulin peak and reduce variations in temperature and impact that blood sugar monitoring is produced.
In sum, the present invention has effectively overcome various shortcoming of the prior art and tool high industrial utilization.
Above-described embodiment is illustrative principle of the present invention and effect thereof only, but not for limiting the present invention.Any person skilled in the art scholar all can, under spirit of the present invention and category, modify or change above-described embodiment.Therefore, such as in affiliated technical field, have and conventionally know that the knowledgeable, not departing from all equivalence modifications that complete under disclosed spirit and technological thought or changing, must be contained by claim of the present invention.
Claims (9)
1. a skin hot type artificial pancreas, is characterized in that, described artificial pancreas comprises:
For the variation of Real-Time Monitoring blood in human body in sugar, and the blood sugar monitoring equipment of output blood glucose value; Described blood sugar monitoring equipment comprises glucose sensor and Dynamic Blood Glucose Monitoring device;
For simulating the duct free insulin pump of pattern and the function of human pancreas's physiology excreting insulin; Described duct free insulin pump comprises drug storage unit, administration control unit, administration driver element and insulin indwelling unit, and described insulin is kept somewhere unit and comprised insulin indwelling flexible pipe;
For heating, plant and bury described glucose sensor place, and/or plant and bury the skin heater that described insulin is kept somewhere hose skin histology, described skin heater comprises:
Skin heating film;
Be built in described skin heating film, for heating, plant and bury described glucose sensor place, and/or plant and bury the intensification module that described insulin is kept somewhere hose skin histology;
Be built in and be connected with described intensification module in described skin heating film, for regulating heating parameters to control the temperature control modules of heated perimeter;
Be built in and be connected with described temperature control modules in described skin heating film, for keeping the heat preservation module of described skin histology temperature.
2. skin hot type artificial pancreas according to claim 1, it is characterized in that: described skin heater also comprises the temperature detecting module for detection of described skin histology temperature, described temperature detecting module is built in described skin heating film or is placed in outside described skin heating film; While being built in described skin heating film, described temperature detecting module is connected with described temperature control modules.
3. skin hot type artificial pancreas according to claim 1, is characterized in that: described glucose sensor and described insulin indwelling flexible pipe are planted and be embedded in same subcutaneous tissue place, and described skin hot type artificial pancreas only needs a skin heater; Described glucose sensor and described insulin indwelling flexible pipe are planted and are embedded in different subcutaneous tissue place, and described skin hot type artificial pancreas needs one or two skin heater.
4. skin hot type artificial pancreas according to claim 1, is characterized in that: the power supply mode of described skin heater comprises: on described skin heating film, place the mutual inductor that can receive wireless power; Or described skin heating film is connected on the built-in power of described duct free insulin pump or described blood sugar monitoring equipment by wire.
5. skin hot type artificial pancreas according to claim 1, is characterized in that: the power supply mode of described skin heater also comprises described skin heating film is connected to external power source by wire.
6. skin hot type artificial pancreas according to claim 1, is characterized in that: described skin heating film is resistance heating film.
7. skin heating artificial pancreas according to claim 6, is characterized in that: the electrically insulating material of described resistance heating film is flexible material or rigid material.
8. skin hot type artificial pancreas according to claim 1, is characterized in that: the heating temp of described skin heater is controlled between 32 degrees Celsius to 45 degrees Celsius.
9. skin hot type artificial pancreas according to claim 1, is characterized in that: described duct free insulin pump is by wireless mode or wired mode and described blood sugar monitoring equipment connection.
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| CN201310552894.0A CN103550843B (en) | 2013-11-08 | 2013-11-08 | Skin hot type artificial pancreas |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105311702A (en) * | 2014-09-03 | 2016-02-10 | 上海移宇科技有限公司 | Throwable duct-free drug delivery system |
| CN108013866A (en) * | 2016-11-02 | 2018-05-11 | 北京大学 | A kind of new sign data detection method and wearable sign detection device |
| CN109330608A (en) * | 2018-08-14 | 2019-02-15 | 林彧宁 | Blood sugar measuring method and device |
| CN113017624A (en) * | 2021-05-24 | 2021-06-25 | 广州新诚生物科技有限公司 | Continuous glucose monitoring and adjusting device |
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| CN113017624B (en) * | 2021-05-24 | 2021-09-24 | 广州新诚生物科技有限公司 | Continuous glucose monitoring and adjusting device |
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