CN109350078A - Blood sugar concentration detection method based on ultra-wideband microwave inverse Fourier transform - Google Patents
Blood sugar concentration detection method based on ultra-wideband microwave inverse Fourier transform Download PDFInfo
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- CN109350078A CN109350078A CN201811222980.4A CN201811222980A CN109350078A CN 109350078 A CN109350078 A CN 109350078A CN 201811222980 A CN201811222980 A CN 201811222980A CN 109350078 A CN109350078 A CN 109350078A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7253—Details of waveform analysis characterised by using transforms
- A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
Abstract
The present invention relates to a kind of blood sugar concentration detection methods based on ultra-wideband microwave inverse Fourier transform, including the following steps: production human body ear-lobe model；Prepare the test blood of different blood sugar concentrations；Vector network analyzer is calibrated and is arranged, the bandwidth of the reflection signal of vector network analyzer is set as 3GHz-10GHz, obtained S21 parameter is stored；The data point for acquiring the S21 frequency domain response of blood glucose solution of the various concentration detected from vector network analyzer is read, the waveform diagram of the frequency domain response is made using plot function；According to the relevant feature of inverse fast Fourier transform, collected data point is come for sampling frequency interval assignment, then in the inverse that the time domain corresponding time-shifting period is sampling time interval；Inverse fast Fourier transform is carried out to the S21 frequency domain response of the blood glucose solution of various concentration；Obtain the consistent relationship of blood sugar concentration Yu ultra-wideband microwave time-domain signal.For blood glucose, subject is detected.
Description
Technical field
The invention belongs to Microwave Nondestructive Testing Techniqne fields, are related to a kind of blood sugar concentration detection method.
Background technique
The variation of various chemical composition contents can really reflect the health status of human body in blood of human body, be clinical diagnosis and
Important information necessary to daily monitoring.Finding one kind being capable of convenient, continuous, effective, accurate, non-invasively blood constituent side
Method is that the mankind fight the ideal dreamed of in lysis for a long time.Due to the real-time detection of the concentration of glucose in blood
There is important value to diabetes are prevented and treated, current research is concentrated mainly on the Non-invasive detection to blood glucose.It is grinding
The method for the feasible non-invasive glucose monitoring studied carefully can be divided into two major classes: one kind is optical means, mainly include near infrared spectroscopy,
The kinds of schemes such as mid-infrared light spectrometry, photocaustic spectroscopy, polarized light measurement technology.Optical means common problem is to people
The optical characteristics understanding of body tissue is deep not enough, can not eliminate the factors such as blood pressure, body temperature, skin, measuring point to survey
The influence of accuracy of measurement.Another kind of is non optical method, mainly includes biological fluid extracting method, ion hyperfiltration, electromagnetic resistivity spectrometry.
Set forth herein use the principle of ultra wide band Electromagnetic Wave Detection blood sugar concentration to be the blood tissues of different blood sugar concentrations
It is different to the absorption, reflection and transmissison characteristic of electromagnetic wave, so that the pulse signal of antenna transmitting propagates when institute in ear-lobe tissue
The electromagnetic field of generation is able to reflect information needed.Ultra-wideband microwave signal has that radiant power is low, the target information amount of carrying simultaneously
Greatly, the advantages that providing grade positioning and lower testing cost, can be as the conventional means of non-destructive testing blood sugar concentration.Therefore have
The method of non-destructive testing blood sugar concentration of necessity exploitation based on ultra-wideband microwave.
Summary of the invention
The present invention provides a kind of utilize in ultra-wideband microwave detection system to the side of human blood glucose concentration progress lossless detection
Method.This method is simple and efficient, can be judged by carrying out inverse Fourier transform to reception signal blood sugar concentration, avoid making
There is the method for injury to human body with puncture etc., enough information can be obtained, blood sugar concentration is detected.Technology of the invention
Scheme is as follows:
A kind of blood sugar concentration detection method based on ultra-wideband microwave inverse Fourier transform, including the following steps:
1) human body ear-lobe model is made；
2) the test blood for preparing different blood sugar concentrations, for obtaining S21 parameter；
3) by ear-lobe model, antenna, vector network analyzer is connected；
4) it calibrates and vector network analyzer is set, the bandwidth of the reflection signal of vector network analyzer is set as 3GHz-
10GHz stores obtained S21 parameter；
5) the S21 frequency domain response for acquiring the blood glucose solution of the various concentration detected from vector network analyzer is read
The S21 parameter of all blood sugar concentrations is subtracted the S21 parameter that blood sugar concentration is 0mg/dl and calibrated, and used by data point
Plot function makes the waveform diagram of the frequency domain response；
6) according to the relevant feature of inverse fast Fourier transform, collected data point is assigned a value of for sampling frequency interval
35MHz, then in the inverse that the time domain corresponding time-shifting period is sampling time interval；
7) inverse fast Fourier transform is carried out to the S21 frequency domain response of the blood glucose solution of various concentration, realizes frequency domain then
The conversion in domain takes the modulus value of data after inverse Fourier transform, the frequency of the data and initial data in time domain enabled
Rate is corresponding；
8) limitation time range is first passed through to eliminate the interference of noise, is reused plot function and is carried out drawing for time domain waveform
System, and the blood glucose solution time domain response of various concentration is compared, obtain blood sugar concentration and ultra-wideband microwave time-domain signal
Consistent relationship.
9) blood glucose subject is detected.
Detailed description of the invention
The S21 parameter of Fig. 1 difference blood sugar concentration.
The time domain waveform of Fig. 2 reception signal.
The time domain waveform of Fig. 3 reception signal enlarged drawing at 0.071ns.
Fig. 4 receives the time domain waveform valley of signal and the relationship of blood sugar concentration
Specific embodiment
Since institutional framework is simple in ear-lobe, capillary can be distributed and be equivalent to one layer of blood layer, different blood glucose are dense
There are different electromagnetic property parameters when spending.It is received to obtain by the antenna of the other side when the ultra-wideband microwave of antenna transmitting passes through ear-lobe
While also there is signal to be reflected back, vector network analyzer can be used and obtain the corresponding S21 parameter of different blood sugar concentrations,
Obtain the rule of blood sugar concentration.Blood of human body is simulated using glucose solution, penetrates ear-lobe using ultra-wideband microwave.Extract letter
S21 parameter number at 6GHz finds out S21 parameter relationship corresponding with blood sugar concentration, and then dense to blood glucose by S21 parameter
Degree is determined.This method can easily determine blood sugar concentration, and colleague does not generate damage to body.Therefore this method is easy to be fast
Victory avoids the injury to human body, can detect to the blood sugar concentration of human body.It is very suitable for the detection of blood sugar concentration.
Fig. 1 is the S21 parameter of different blood sugar concentrations, and corresponding frequency range is 3GHz-10GHz, the concentration of blood layer
Range is 0-500mg/dl.Fig. 2 is the S21 parameter enlarged drawing at 6GHz, and S21 parameter shown in FIG. 1 exists for the ease of observation
It is exaggerated at 6GHz.For the relationship for finding out blood sugar concentration Yu S21 parameter, the S21 value at 6GHz extract and draw
Figure is made, the relationship of blood sugar concentration and the S21 parameter at 6GHz is as shown in Figure 3.
Detailed process is as follows:
1. simulating ear-lobe fat deposit with the box of teflon material production width 80mm high 60mm thickness 6mm first.Wherein, ear
Capillary in hanging down is equivalent to one layer of blood layer.Blood layer both sides are adipose tissue, for the sake of simplicity, molten using glucose
Liquid simulates blood of human body.
2. two antennas are attached to ear-lobe model two sides respectively, the bandwidth of antenna is 12.5GHz (3.5GHz -15GHz).
The concentration range of blood layer be 0-500mg/dl, detection concentration of specimens be 0mg/dl, 50mg/dl, 100mg/dl, 150mg/dl,
200mg/dl, 250mg/dl, 300mg/dl, 350mg/dl, 400mg/dl, 500mg/dl.
3. antenna, vector network analyzer connects by ear-lobe model.
4. calibrating and vector network analyzer being arranged, the bandwidth of the reflection signal of vector network analyzer is set as
Then 300MHz -3GHz stores obtained S21 parameter.
5. reading the S21 frequency domain response for acquiring the blood glucose solution of the various concentration detected from vector network analyzer
Data point.Wherein frequency range is by 3GHz-10GHz, and the waveform diagram of the frequency domain response is made using plot function, such as Fig. 1 institute
Show.
6. according to the relevant feature of inverse fast Fourier transform, collected data point is assigned a value of for sampling frequency interval
35MHz, then in the inverse that the time domain corresponding time-shifting period is sampling time interval.
7. the S21 frequency domain response of the blood glucose solution of pair various concentration carries out inverse fast Fourier transform, frequency domain is realized then
The conversion in domain takes the modulus value of data after inverse Fourier transform plus abs using ifftshift function, so that in obtained time domain
Data can be corresponding with the frequency of initial data.
8. the drafting that plot function carries out waveform diagram is reused by the interference of noise is eliminated by limitation time range,
The blood glucose solution time domain response of various concentration as shown in Fig. 2, and being compared and being illustrated in figure 3 time domain waveform by time domain waveform
Enlarged drawing at 0.071ns, table 1 are the time-domain signal valley of the various concentration arrived extracted, and the data in table 1 are drawn
As shown in figure 4, obtaining the consistent relationship of blood sugar concentration Yu ultra-wideband microwave time-domain signal.
9. antenna only need to be attached to subject's ear-lobe two sides to detect for blood glucose subject.
10. the S21 value that will test extracts valley after treatment, it is dense that blood glucose can be obtained in the rule in corresponding diagram 4
Angle value.
The time-domain signal valley of 1 various concentration of table
11. result above obtains, using the method that inverse Fourier transform detects blood sugar concentration have it is very high can
Row and validity.
Detection method of the invention is summarized below:
1) human body ear-lobe model is made；
2) the test blood of different blood sugar concentrations is prepared；
3) by ear-lobe model, antenna, vector network analyzer is connected；
4) it calibrates and vector network analyzer is set, the bandwidth of the signal of vector network analyzer is set as 3GHz-
Then 10GHz stores obtained S21 parameter；
5) the S21 frequency domain response for acquiring the blood glucose solution of the various concentration detected from vector network analyzer is read
The S21 parameter of all blood sugar concentrations is subtracted the S21 parameter that blood sugar concentration is 0mg/dl and calibrated by data point.Wherein frequency
Range makes using plot function the waveform diagram of the frequency domain response by 3GHz-10GHz；
6) according to the relevant feature of inverse fast Fourier transform, collected data point is assigned a value of for sampling frequency interval
35MHz, then in the inverse that the time domain corresponding time-shifting period is sampling time interval.
7) inverse fast Fourier transform is carried out to the S21 frequency domain response of the blood glucose solution of various concentration, realizes frequency domain then
The conversion in domain takes the modulus value of data after inverse Fourier transform plus abs using ifftshift function, so that in obtained time domain
Data can be corresponding with the frequency of initial data.
8) interference that noise will be eliminated by limitation time range, reuses the drafting that plot function carries out waveform diagram,
The blood glucose solution time domain response of various concentration as shown in Fig. 2, and being compared and being illustrated in figure 3 time domain waveform by time domain waveform
Enlarged drawing at 0.071ns, table 1 are the time-domain signal valley of the various concentration arrived extracted, and the data in table 1 are drawn
As shown in figure 4, obtaining the consistent relationship of blood sugar concentration Yu ultra-wideband microwave time-domain signal.
9) for blood glucose subject, antenna only need to be attached to subject's ear-lobe two sides to detect.
10) the S21 value that will test extracts valley after treatment, and it is dense that blood glucose can be obtained in the rule in corresponding diagram 4
Angle value.
This method can easily determine blood sugar concentration, while not generate damage to body.Experimental result confirms this method
It is very feasible effective.
Claims (1)
1. a kind of blood sugar concentration detection method based on ultra-wideband microwave inverse Fourier transform, including the following steps:
1) human body ear-lobe model is made；
2) the test blood for preparing different blood sugar concentrations, for obtaining S21 parameter；
3) by ear-lobe model, antenna, vector network analyzer is connected；
4) it calibrates and vector network analyzer is set, the bandwidth of the reflection signal of vector network analyzer is set as 3GHz-
10GHz stores obtained S21 parameter；
5) data for acquiring the S21 frequency domain response of blood glucose solution of the various concentration detected from vector network analyzer are read
The S21 parameter of all blood sugar concentrations is subtracted the S21 parameter that blood sugar concentration is 0mg/dl and calibrated, and uses plot letter by point
Number makes the waveform diagram of the frequency domain response；
6) according to the relevant feature of inverse fast Fourier transform, collected data point is assigned a value of for sampling frequency interval
35MHz, then in the inverse that the time domain corresponding time-shifting period is sampling time interval；
7) inverse fast Fourier transform is carried out to the S21 frequency domain response of the blood glucose solution of various concentration, realizes frequency domain to time domain
Conversion, takes the modulus value of data after inverse Fourier transform, the frequency phase of the data and initial data in time domain enabled
It is corresponding；
8) limitation time range is first passed through to eliminate the interference of noise, reuses the drafting that plot function carries out time domain waveform,
And the blood glucose solution time domain response of various concentration is compared, show that blood sugar concentration is corresponding with ultra-wideband microwave time-domain signal
Rule.
9) blood glucose subject is detected.
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Cited By (4)
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| CN110507331A (en) * | 2019-08-30 | 2019-11-29 | 上海海事大学 | A kind of invasive blood sugar measuring system based on ultrasonic velocity method |
| CN110916680A (en) * | 2019-11-29 | 2020-03-27 | 天津大学 | Non-invasive blood glucose concentration detection method based on S21 phase |
| CN111632228A (en) * | 2020-05-19 | 2020-09-08 | 中国科学院深圳先进技术研究院 | Closed-loop artificial pancreas system based on wearable monitoring method |
| CN116712056A (en) * | 2023-08-07 | 2023-09-08 | 合肥工业大学 | Characteristic image generation and identification method, equipment and storage medium for electrocardiogram data |
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Cited By (6)
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|---|---|---|---|---|
| CN110507331A (en) * | 2019-08-30 | 2019-11-29 | 上海海事大学 | A kind of invasive blood sugar measuring system based on ultrasonic velocity method |
| CN110916680A (en) * | 2019-11-29 | 2020-03-27 | 天津大学 | Non-invasive blood glucose concentration detection method based on S21 phase |
| CN111632228A (en) * | 2020-05-19 | 2020-09-08 | 中国科学院深圳先进技术研究院 | Closed-loop artificial pancreas system based on wearable monitoring method |
| CN111632228B (en) * | 2020-05-19 | 2021-05-25 | 中国科学院深圳先进技术研究院 | Closed-loop artificial pancreas system based on wearable monitoring method |
| CN116712056A (en) * | 2023-08-07 | 2023-09-08 | 合肥工业大学 | Characteristic image generation and identification method, equipment and storage medium for electrocardiogram data |
| CN116712056B (en) * | 2023-08-07 | 2023-11-03 | 合肥工业大学 | Characteristic image generation and identification method, equipment and storage medium for electrocardiogram data |
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