CN107595318A - A kind of Woundless blood sugar concentration detection method and equipment - Google Patents
A kind of Woundless blood sugar concentration detection method and equipment Download PDFInfo
- Publication number
- CN107595318A CN107595318A CN201710859539.6A CN201710859539A CN107595318A CN 107595318 A CN107595318 A CN 107595318A CN 201710859539 A CN201710859539 A CN 201710859539A CN 107595318 A CN107595318 A CN 107595318A
- Authority
- CN
- China
- Prior art keywords
- blood sugar
- target
- sugar concentration
- data
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
This application provides a kind of Woundless blood sugar concentration detection method and equipment, including：Spread speed of the ultrasonic wave in target measurement site is determined, first object blood sugar concentration is determined based on spread speed；Obtain target data, second target blood glucose concentration is determined based on target data, temperature data, humidity data, radiation degrees of data, blood oxygen saturation data and the pulse rate data that target data obtains for measurement target measurement site, it is determined that acting on the frequency of oscillation of the oscillating circuit of target measurement site, and the 3rd target blood glucose concentration is determined based on frequency of oscillation；Judge whether first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration meet default deviation decision condition, if it is, being weighted to three blood sugar concentrations averagely, obtain final blood sugar concentration.The blood sugar concentration accuracy that the method and apparatus that the application provides is determined is higher, and detection process need not extract blood sample, as noninvasive blood sugar detecting method, and pollution-free and price is low.
Description
Technical field
The present invention relates to blood sugar concentration detection technique field, more particularly to a kind of Woundless blood sugar concentration detection method and set
It is standby.
Background technology
Diabetes are a kind of metabolic diseases of multi-pathogenesis, and its distinguishing feature is chronic hyperglycemia, while with insulin
Sugar, fat and protein metabolism disorder symptoms caused by hyposecretion or effect obstacle, identical with cancer, it is medical field hardly possible
With the difficult and complicated cases captured.At present, diabetes affect the health of nearly 300,000,000 people in the whole world, and China is to be only second to print in the world
The ill country of the second largest diabetes of degree.It is therefore, dense to sufferer blood glucose due to not yet working out the cure method of diabetes at present
The detection of degree is particularly important.
At present, the detection of blood sugar concentration can be divided into invasive and noninvasive two ways.Invasive mode mainly passes through biochemical analysis
Instrument extracts the blood sample of patient, and blood glucose concentration value is calculated according to corresponding biochemical reaction result, and this method precision is high,
But sufferer body surface is wound, testing cost is high, easily causes pollution.Non-invasive methods has optical means, electrochemical method etc., wherein,
Noninvasive Blood Glucose Detection Methods based on optical means have photocaustic spectroscopy, Raman spectroscopy, fluorescence method, polarimetry, optical coherence
Tomography, near infrared spectroscopy and mid-infrared light spectrometry etc., but due to weak output signal, the more, signal to noise ratio of interference is low and people
The individual difference of body, up to the present these methods are all also in conceptual phase.Therefore, a kind of accuracy of detection height, nothing are needed badly
Pollution, low-cost Noninvasive Blood Glucose Detection Methods and equipment.
The content of the invention
In view of this, the invention provides a kind of Woundless blood sugar concentration detection method and equipment, to provide a kind of detection essence
High, pollution-free, low-cost Noninvasive Blood Glucose Detection Methods and equipment are spent, its technical scheme is as follows：
A kind of Woundless blood sugar concentration detection method, including：
Spread speed of the ultrasonic wave in target measurement site is determined, determines blood sugar concentration as based on the spread speed
One target blood glucose concentration；
Target data is obtained, blood sugar concentration is determined as the second target blood glucose concentration based on the target data, wherein, institute
It is the temperature data, humidity data, radiancy obtained by the DATA REASONING unit measurement target measurement site to state target data
Data, blood oxygen saturation data and pulse rate data；
It is determined that acting on the frequency of oscillation of the oscillating circuit of the target measurement site, and determined based on the frequency of oscillation
Blood sugar concentration is as the 3rd target blood glucose concentration；
Judging the first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration is
It is no to meet default deviation decision condition, if it is, to first blood sugar concentration, second blood sugar concentration and described
Three blood sugar concentrations are weighted averagely, obtain final blood sugar concentration data.
Wherein, it is described to judge first object blood sugar concentration, the second target blood glucose concentration and the 3rd target
Whether blood sugar concentration meets default deviation decision condition, including：
Judge that the first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration are appointed
Whether the deviation of meaning between the two is respectively less than predetermined deviation.
The Woundless blood sugar concentration detection method, in addition to：
When the first object blood sugar concentration is unsatisfactory for the default deviation decision condition, the determination is re-executed
For ultrasonic wave in the spread speed of target measurement site, the step for determining blood sugar concentration based on the spread speed, is multiple, obtains
Multiple first blood sugar concentrations, the multiple first blood sugar concentration is weighted averagely, obtains new first object blood sugar concentration,
Then it is dense that the judgement first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose are performed
Whether degree meets default deviation decision condition；
When the second target blood glucose concentration is unsatisfactory for the default deviation decision condition, the acquisition is re-executed
Target data, determine that the step for blood sugar concentration is as the second target blood glucose concentration is multiple based on the target data, obtain more
Individual second blood sugar concentration, the multiple second blood sugar concentration is weighted averagely, obtains the second new target blood glucose concentration, so
After perform and described judge first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration
Whether default deviation decision condition is met；
When the 3rd target blood glucose concentration is unsatisfactory for the default deviation decision condition, the determination is re-executed
Act on the frequency of oscillation of the oscillating circuit of the target measurement site, and based on the frequency of oscillation determine blood sugar concentration this
Step is multiple, obtains multiple 3rd blood sugar concentrations, the multiple 3rd blood sugar concentration is weighted averagely, obtains new the 3rd
Target blood glucose concentration, then perform and described judge the first object blood sugar concentration, the second target blood glucose concentration and described
Whether the 3rd target blood glucose concentration meets default deviation decision condition.
Wherein, the determination ultrasonic wave determines blood glucose in the spread speed of target measurement site based on the spread speed
Concentration as first object blood sugar concentration, including：
The ultrasonic wave and ultrasonic wave receiving unit sent based on ultrasonic wave transmitting element to the target measurement site is from institute
State the ultrasonic wave that target measurement site receives and determine spread speed of the ultrasonic wave in target measurement site；
Determine the phase difference between the ultrasonic wave of the ultrasonic wave and reception sent as target phase based on the spread speed
Potential difference；
By the target phase difference, the first object blood glucose is determined according to the functional relation of phase difference and blood sugar concentration
Concentration.
Wherein, it is described that blood sugar concentration is determined as the second target blood glucose concentration based on the target data, including：
Heat exchange metabolic rate is determined by the temperature data, humidity data and radiation degrees of data, and passes through the temperature
Data determine CBF；
By the heat exchange metabolic rate, the blood oxygen saturation data, the pulse rate data and the CBF, according to
The functional relation of heat exchange metabolic rate, blood oxygen saturation data, pulse rate data and CBF and blood sugar concentration determines described second
Target blood glucose concentration.
Wherein, the frequency of oscillation for determining to act on the oscillating circuit of the target measurement site, and being shaken based on described
Swing frequency and determine blood sugar concentration as the 3rd target blood glucose concentration data, including：
Acquisition acts on low frequency signal caused by the oscillating circuit of the target measurement site, and passes through the low frequency signal
Determine the frequency of oscillation；
By the frequency of oscillation, the 3rd target blood glucose is determined according to the functional relation of frequency of oscillation and blood sugar concentration
Concentration.
A kind of Woundless blood sugar concentration detection device, is comprised at least：Processing unit, ultrasonic measuring device, DATA REASONING list
Member and RC oscillating circuits；
The ultrasonic measuring device, for sending ultrasonic wave to target measurement site by ultrasonic wave transmitting element, and
Ultrasonic signal after target measurement site transmission is received by ultrasonic wave receiving unit；
The DATA REASONING unit, for measuring the target measurement site, obtain temperature data, humidity data, radiation
Degrees of data, blood oxygen saturation data and pulse rate data；
The RC oscillating circuits, for acting on the target measurement site, produce low frequency signal；
The processing unit, ultrasonic signal and the ultrasonic wave for being sent based on the ultrasonic wave transmitting element are connect
Receive the ultrasound information that unit receives and determine spread speed of the ultrasonic wave in target measurement site, determined based on the spread speed
Blood sugar concentration is as first object blood sugar concentration；And satisfied based on the temperature data, humidity data, radiation degrees of data, blood oxygen
Determine blood sugar concentration as the second target blood glucose concentration with degrees of data and pulse rate data；And produced based on the RC oscillating circuits
Raw low frequency signal determines frequency of oscillation, and determines blood sugar concentration as the 3rd target blood glucose concentration numbers based on the frequency of oscillation
According to；And judge that the first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration are
It is no to meet default deviation decision condition, if it is, to the first object blood sugar concentration, the second target blood glucose concentration
It is weighted averagely with the 3rd target blood glucose concentration, obtains final blood sugar concentration.
Wherein, the DATA REASONING unit includes：Temperature sensor, humidity sensor, radiancy sensor, photo-electric arteries and veins
Fight sensor and oxygen saturation measurement unit.
Wherein, the processing unit is DSP, and the DSP is TMS320F2812.
The Woundless blood sugar concentration detection device also includes：Pretreatment unit, memory cell and display unit；
The pretreatment unit, the data for being exported to the DATA REASONING unit pre-process；
The memory cell, for storing the data of the processing unit processes；
The display unit, the blood sugar concentration data determined for showing the processing unit.
Woundless blood sugar concentration detection method provided by the invention and equipment, detected first using three kinds of different blood sugar concentrations
Methods In Detecting Blood Glucose concentration, then the blood sugar concentration detected using three kinds of methods is merged, i.e., three kinds of methods examined
The blood sugar concentration measured is weighted averagely, and so as to obtain final blood sugar concentration, the blood sugar concentration that this method is determined is smart
True property is higher, and this detection method need not extract blood sample, as noninvasive blood sugar detecting method, therefore, pollution-free,
Price is low.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is the required accompanying drawing used in technology description to be briefly described, it should be apparent that, drawings in the following description are only this
The embodiment of invention, for those of ordinary skill in the art, on the premise of not paying creative work, can also basis
The accompanying drawing of offer obtains other accompanying drawings.
Fig. 1 is the schematic flow sheet of Woundless blood sugar concentration detection method provided in an embodiment of the present invention；
Fig. 2 is RC oscillation measurements circuit diagram provided in an embodiment of the present invention；
Fig. 3 is the structural representation of Woundless blood sugar concentration detection device provided in an embodiment of the present invention.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other under the premise of creative work is not made
Embodiment, belong to the scope of protection of the invention.
The embodiments of the invention provide a kind of Woundless blood sugar concentration detection method, referring to Fig. 1, showing the Woundless blood sugar
The schematic flow sheet of concentration detection method, it can include：
Step S101：Spread speed of the ultrasonic wave in target measurement site is determined, blood sugar concentration is determined based on spread speed
As first object blood sugar concentration.
Wherein, target measurement site is blood sugar test position, and the position is preferably that rich blood vessel, blood volume are abundant and exposed
Position, such as web between finger tip, palm, forefinger and thumb.
Step S102：Target data is obtained, determines blood sugar concentration as the second target blood glucose concentration based on target data.
Wherein, target data be by DATA REASONING unit measure target measurement site obtain temperature data, humidity data,
Radiate degrees of data, blood oxygen saturation data and pulse rate data.
Step S103：It is determined that the frequency of oscillation of the oscillating circuit of target measurement site is acted on, and it is true based on frequency of oscillation
Blood sugar concentration is determined as the 3rd target blood glucose concentration data.
It should be noted that the present embodiment does not limit step S101~step S103 execution sequence, as long as including step
Rapid S101~step S103 belongs to the scope of protection of the invention.
Step S104：Whether judge first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration
Meet default deviation decision condition.
Step S105：When first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration meet in advance
If deviation decision condition when, the first blood sugar concentration, the second blood sugar concentration and the 3rd blood sugar concentration are weighted average, obtained
Final blood sugar concentration data.
Woundless blood sugar concentration detection method provided in an embodiment of the present invention, detected first using three kinds of different blood sugar concentrations
Methods In Detecting Blood Glucose concentration, then the blood sugar concentration detected using three kinds of methods is merged, i.e., three kinds of methods examined
The blood sugar concentration measured is weighted averagely, and so as to obtain final blood sugar concentration, the blood sugar concentration that this method is determined is smart
True property is higher, and this detection method need not extract blood sample, as noninvasive blood sugar detecting method, therefore pollution-free,
Price is low.
In the Woundless blood sugar concentration detection method that above-described embodiment provides, biography of the ultrasonic wave in target measurement site is determined
Speed is broadcast, blood sugar concentration is determined as first object blood sugar concentration based on spread speed, including：Based on ultrasonic wave transmitting element to
The ultrasonic wave that the ultrasonic wave and ultrasonic wave receiving unit that target measurement site is sent receive from target measurement site determines ultrasound
Spread speed of the ripple in target measurement site；The phase between the ultrasonic wave of the ultrasonic wave and reception sent is determined based on spread speed
Potential difference is as target phase difference；By target phase difference, first object is determined according to the functional relation of phase difference and blood sugar concentration
Blood sugar concentration.
Ultrasonic wave is the mechanical vibration wave that a kind of frequency is 20kHz, can produce and receive ultrasonic wave, production by piezoelectric ceramics
Cause trouble and apply the electric pulse of certain frequency to piezoelectric ceramics, cause mechanical oscillation, so as to produce ultrasonic wave, in receiving terminal, piezoelectricity
Ceramics can vibrate so as to produce electric signal therewith when running into ultrasonic wave.In the present embodiment, by the ultrasound of ultrasonic measuring device
The both sides that ripple transmitting element and ultrasonic wave receiving unit are placed in target measurement site measure.The spread speed of ultrasonic wave is by people
Body blood sugar concentration C determines that blood sugar concentration is higher, and the spread speed of ultrasonic wave is faster, i.e. the propagation of blood sugar concentration C and ultrasonic wave
Following relation be present in speed：
C∝s (1)
In a kind of possible implementation, phase-comparison method can be used to determine the spread speed of ultrasonic wave, its principle is
The spread speed of phase difference, phase difference and ultrasonic wave between the ultrasonic signal of transmitting and the ultrasonic signal of reception be present
Following relation between s be present：
Wherein, f represents the frequency of ultrasonic wave, and l represents the distance between ultrasonic wave transmitting element and ultrasonic wave receiving unit.
By above formula (1) and formula (2), it can be deduced that, following relation be present with phase difference in blood sugar concentration C：
By determining that the spread speed of ultrasonic wave can determine that ultrasonic wave transmitting element is sent it can be seen from formula (1)~(3)
Ultrasonic signal and the ultrasonic signal that receives of ultrasonic wave receiving unit between phase difference, and then blood sugar for human body can be obtained
Concentration.
It should be noted that in the present embodiment, can be beforehand through ultrasound examination experiment porch be built, with reference to oral Portugal
Grape sugar tolerance is tested, and obtains the rule between phase difference and blood sugar concentration, and the function established between blood sugar concentration and phase difference closes
System.When determining target phase difference, the first mesh can be determined based on the functional relation between the blood sugar concentration and phase difference
Mark blood sugar concentration.
In the Woundless blood sugar concentration detection method that above-described embodiment provides, blood sugar concentration conduct is determined based on target data
Second target blood glucose concentration, including：Heat exchange metabolic rate is determined by temperature data, humidity data and radiation degrees of data, and led to
Excess temperature degrees of data determines CBF；By heat exchange metabolic rate, blood oxygen saturation data, pulse rate data and CBF, according to heat
Exchange metabolic rate, blood oxygen saturation data, pulse frequency and the functional relation of CBF and blood sugar concentration and determine that the second target blood glucose is dense
Degree.
Wherein, temperature data can be obtained by temperature sensor measurement target measurement site, and humidity data can be by humidity sensor
Device measurement target measurement site obtains, and radiation degrees of data can measure target measurement site by radiancy sensor and obtain, pulse frequency number
Obtained according to target measurement site can be measured by photo-electric pulse transducer, blood oxygen saturation data can be by oxygen saturation measurement list
Member measurement target measurement site obtains.
It is assumed that human body, under quiescent condition, accumulation of heat rate is 0, i.e. quantity of heat production is equal with heat dissipation capacity, and externally done mechanical work is
0, human blood glucose concentration and blood oxygen capacity rise strengthen along with body local metabolic rate, in this case heat caused by metabolism
Also increase immediately.Human body quantity of heat production and blood sugar concentration, blood oxygen capacity and pulse frequency have certain correlation, hemoglobin number in blood
Amount, capillary blood flow, blood oxygen saturation are relevant with oxygen capacity.Human-body radiating mode be mainly heat transfer, heat radiation and
Thermal convection current.Body local heat production rate can be described by body local metabolic rate, and body local VPV can be by body local capillary
Vascular flow amount describes.Following relation can be drawn through analysis：
GLU=F (M, SpO2, BF, PF, c) and (4)
Wherein, GLU is blood sugar concentration, and M is heat exchange metabolic rate, SpO2For blood oxygen saturation, BF is CBF, and PF is arteries and veins
Rate, c are constant.Specifically, SpO2It can be measured by oxygen saturation measurement unit, BF can the temperature based on temperature sensor measurement
Degrees of data is determined, and pulse frequency can be measured by photo-electric pulse transducer, for heat exchange metabolic rate M, work as target measurement site
For hand when, it can be calculated by formula (5)：
Wherein, Tr is that human body refers to table radiancy, and tf is that human body refers to table temperature, and tw is current environmental temperature, and Rh is to work as front ring
Border relative humidity, d are finger diameter.
In the Woundless blood sugar concentration detection method that above-described embodiment provides, it is determined that acting on the vibration of target measurement site
The frequency of oscillation of circuit, and blood sugar concentration is determined as the 3rd target blood glucose concentration data based on frequency of oscillation, including：Obtain and make
Frequency of oscillation is determined for low frequency signal caused by the oscillating circuit of target measurement site, and by low frequency signal；Pass through vibration
Frequency, the 3rd target blood glucose concentration is determined according to the functional relation of frequency of oscillation and blood sugar concentration.
Because the electric conductivity of blood of human body increases with the increase of blood sugar concentration, on microcosmic, usual cell membrane is equivalent to
Electric capacity, when the capacitive reactance of cell membrane reduces, directly result in the conductive increase of capacitive of blood, in addition, blood sugar concentration can change it is red
The deformability and aggregation of cell, directly affect the electric conductivity of tissue.The change of blood electric conductivity can vibrate electricity by RC
The change of road frequency obtains.Referring to Fig. 2, R is input resistance, C is parasitic capacitance, and Z is the transmission letter of skin histology electric conductivity
Number, T are the time delay of the system, and Es disturbs for skin surface, and f is the frequency of oscillation of oscillating circuit.Can by frequency of oscillation f
To obtain the electric conductivity Z of skin histology, and then obtain the functional relation between blood sugar concentration and f.Determining to act on target
After the frequency of oscillation of the oscillating circuit of measuring point, and the 3rd can be determined based on the functional relation of blood sugar concentration and frequency of oscillation
Target blood glucose concentration.
First object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose are determined based on above-mentioned three kinds of methods
After concentration, it is default to judge whether first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration meet
Decision condition is biased, specifically, can determine whether first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration
Arbitrarily whether deviation between the two is respectively less than predetermined deviation, if first object blood sugar concentration, the second target blood glucose concentration and
Any deviation between the two of 3rd target blood glucose concentration is respectively less than predetermined deviation, then can determine that first object blood sugar concentration, the
Two target blood glucose concentration and the 3rd target blood glucose concentration meet default deviation decision condition, then to first object blood sugar concentration,
Second target blood glucose concentration and the 3rd target blood glucose concentration are weighted averagely, so as to obtain final blood sugar concentration.
Specifically, final blood sugar concentration can be calculated by following formula：
SM=SM1*W1+SM2*W2+SM3*W3 (6)
Wherein, SM is final blood sugar concentration, SM1For first object blood sugar concentration, W1For the power of first object blood sugar concentration
Weight, SM2For the second target blood glucose concentration, W2For the weight of the second target blood glucose concentration, SM3For the 3rd target blood glucose concentration, W3For
The weight of 3rd target blood glucose concentration.
It should be noted that it sometimes there may be first object blood sugar concentration, the second target blood glucose concentration and
Three target blood glucose concentration are unsatisfactory for the situation of default deviation decision condition, and based on this, the method that above-described embodiment provides may be used also
With including：
When first object blood sugar concentration is unsatisfactory for default deviation decision condition, step S101 is re-executed more times, obtain
Multiple first blood sugar concentrations are obtained, multiple first blood sugar concentrations is weighted averagely, obtains new first object blood sugar concentration, so
Step S104 is performed afterwards；When the second target blood glucose concentration is unsatisfactory for default deviation decision condition, step S102 is re-executed
Repeatedly, multiple second blood sugar concentrations are obtained, multiple second blood sugar concentrations is weighted averagely, obtains the second new target blood glucose
Concentration, then perform step S104；When the 3rd target blood glucose concentration is unsatisfactory for default deviation decision condition, step is re-executed
Suddenly more times of S103, multiple 3rd blood sugar concentrations are obtained, multiple 3rd blood sugar concentrations is weighted averagely, obtains the 3rd new mesh
Blood sugar concentration is marked, then performs step S104.
Exemplary, by first object blood sugar concentration compared with the second target blood glucose concentration, if first object blood
The bias of sugared concentration and the second target blood glucose concentration is more than predetermined deviation, then it is default to show that first object blood sugar concentration is unsatisfactory for
Deviation decision condition, then performed repeatedly by step S101 again, obtain multiple first blood sugar concentrations, it is necessary to illustrate, at this
In embodiment, performed by step S101 it is multiple, obtain the implementation of multiple first blood sugar concentrations have it is a variety of, a kind of possible
In implementation, execution times N can be preset, after each execution of step S101, it is determined that current execution number is
It is no to reach preset times N, if not up to preset times N, continues executing with step S101, if current execution number is
Reach preset times N, then stop performing, obtain N number of first blood sugar concentration, then, N number of first blood sugar concentration of acquisition is carried out
Weighted average, obtain new first object blood sugar concentration；In alternatively possible implementation, determined using timer
When, for example, timer timing 60 seconds, after each execution of step S101, if currently be not up to timing, continue
Step S101 is performed, until reach timing, M the first blood sugar concentrations that timing is determined in 60 seconds are weighted flat
, new first object blood sugar concentration is obtained.
Blood sugar concentration detection method provided in an embodiment of the present invention, distinguished using three kinds of Woundless blood sugar Concentration Testing algorithms true
Determine blood sugar concentration, and use weighting algorithm and compensation for calibrating errors algorithm, the higher human blood glucose concentration value of precision can be obtained.
In above-mentioned implementation, when first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose are dense
When the blood sugar concentration for being unsatisfactory for default deviation decision condition in degree be present, the blood sugar concentration is redefined, meets it default
Deviation decision condition.
It should be noted that in alternatively possible implementation, when first object blood sugar concentration, the second target blood glucose
, also can be direct when a blood sugar concentration for being unsatisfactory for default deviation decision condition in concentration and the 3rd target blood glucose concentration be present
Two other blood sugar concentration is weighted averagely, so that it is determined that final blood sugar concentration.Exemplary, the second target blood glucose is dense
Degree is unsatisfactory for default deviation decision condition, then can carry out first object blood sugar concentration and the 3rd target blood glucose concentration as the following formula
Weighted average：
SM=(W1+W1/2)*SM1+(W3+W3/2)*SM3 (7)
The embodiment of the present invention additionally provides a kind of Woundless blood sugar concentration detection device, referring to Fig. 3, showing that the blood glucose is dense
The structural representation of detection device is spent, can at least be included：Processing unit 301, ultrasonic measuring device 302, DATA REASONING list
303 and RC of member oscillating circuits 304.
Ultrasonic measuring device 302, for sending ultrasonic wave to target measurement site by ultrasonic wave transmitting element 3021,
And the ultrasonic signal after target measurement site transmits is received by ultrasonic wave receiving unit 3022.
When being measured using ultrasonic measuring device 302, ultrasonic wave transmitting element 3021 is placed in target measurement site one
Side, ultrasonic wave receiving unit 3022 is placed in target measurement site opposite side.
Wherein, DATA REASONING unit 303, for measuring target measurement site, temperature data, humidity data, radiation are obtained
Degrees of data, blood oxygen saturation data and pulse rate data.
Wherein, DATA REASONING unit 303 can include temperature sensor 3031, humidity sensor 3032, radiancy sensing
Device 3033, photo-electric pulse transducer 3034 and oxygen saturation measurement unit 3035.Temperature sensor 3031, for measuring mesh
Measuring point is marked, obtains temperature data；Humidity sensor 3032, for measuring target measurement site, obtain humidity data；Radiation
Sensor 3033 is spent, for measuring target measurement site, obtains radiation degrees of data；Photo-electric pulse transducer 3034, for surveying
Target measurement site is measured, obtains pulse rate data；Oxygen saturation measurement unit 3035, for measuring target measurement site, obtain
Blood oxygen saturation data.
RC oscillating circuits 304, for acting on target measurement site, produce low frequency signal.
Specifically, RC oscillating circuits 304 are placed in RC oscillating circuits when measuring target measurement site, by measurement target measurement
Between 304 electric capacity.
Processing unit 301, ultrasonic signal and ultrasonic wave receiving unit for being sent based on ultrasonic wave transmitting element are connect
The ultrasound information of receipts determines spread speed of the ultrasonic wave in target measurement site, and blood sugar concentration conduct is determined based on spread speed
First object blood sugar concentration；And based on temperature data, humidity data, radiation degrees of data, blood oxygen saturation data and pulse frequency number
According to determination blood sugar concentration as the second target blood glucose concentration；And vibration is determined based on low frequency signal caused by RC oscillating circuits
Frequency, and determine blood sugar concentration as the 3rd target blood glucose concentration data based on frequency of oscillation；And judge first object blood glucose
Whether concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration meet default deviation decision condition, if it is, right
First blood sugar concentration, the second blood sugar concentration and the 3rd blood sugar concentration are weighted averagely, obtain final blood sugar concentration.
In a kind of possible implementation, processing unit 301 can be DSP, in order to improve data operation speed, simplification
Operate and make portable devices, the new generation DSP that TI companies can be selected in DSP deals with device TMS320F2812, and the processor uses 32
Position central processing unit, improves disposal ability, it has the characteristics of high-performance, low-power consumption, and its core voltage is 1.8V, and periphery connects
Mouthful voltage is 3.3V, and dominant frequency possesses the on-chip memory and On-Chip peripheral of Large Copacity up to 150MHz.
It can also include in addition, the present invention is the Woundless blood sugar concentration detection device that embodiment provides：Pretreatment unit
305th, memory cell 306 and display unit 307.
Wherein, pretreatment unit 305 is connected with DATA REASONING unit 303, is also connected with processing unit 301, for logarithm
Pre-processed according to the data of the measurement output of Unit 303, pretreated data are then sent to processing unit 301.Specifically
, pretreatment unit 305 can be signal processing circuit, and it measures each sensor, measuring unit in DATA REASONING unit 303
Each circuit-switched data carry out A/D conversions, and pass through the voltage model that anti-phase operational amplification circuit and precision resister adjust each circuit-switched data
Enclose, here from amplifier LM324D, realize LPF with 0.1uF electric capacity, filter out noise and interference, by the result after conversion
It is sent into 301 further computing of processing unit.
Memory cell 306 can be extension storage circuit, and it is connected with processing unit 301, storage processing unit processing 301
Data.
Woundless blood sugar concentration detection device provided in an embodiment of the present invention can also include data processing circuit 308, data
Process circuit 308 is connected with processing unit 301, is also connected with display unit 307, its blood for obtaining the processing of processing unit 301
Sugared concentration data is processed into the data that can be shown in display unit 307.Wherein, display unit 307 can with but be not limited to LCD and show
Show circuit.LCD, which is shown, can be selected YM320240, and it uses 320*240 dot matrix, meets resolution requirement, and TMS320F2812 sheets
Body has LCD interfaces, here from 74ALVC16245 as its driving chip.
Woundless blood sugar concentration detection device provided in an embodiment of the present invention can also include connecing with what processing unit 301 was connected
Mouth circuit 309 and the power supply and reseting module 310 being connected with processing unit 301.Host computer can pass through interface circuit 309 and place
Manage unit 301 carry out information exchange, as host computer by interface circuit 309 to processing unit 301 send out control instruction.Wherein, connect
Mouthful circuit 309 can with but be not limited to RS232 interface circuit.
Woundless blood sugar concentration detection device provided in an embodiment of the present invention, three kinds of different blood sugar concentration detection sides can be used
Method detects blood sugar concentration, i.e. the spread speed of ultrasonic wave can be determined based on the measurement result of ultrasonic measurement, based on ultrasonic wave
Spread speed determines first object blood sugar concentration, temperature data, the humidity number that can be measured based on each sensor and measuring unit
The second target blood glucose concentration is determined according to, blood oxygen saturation data and pulse rate data, and the frequency of oscillation based on RC oscillating circuits is true
Fixed 3rd target blood glucose concentration data, is then merged the blood sugar concentration detected using three kinds of methods, i.e., to three kinds
The blood sugar concentration that method detects is weighted averagely, so as to obtain final blood sugar concentration, the blood glucose that this method is determined
Concentration accuracy is higher, and this detection method need not extract blood sample, as noninvasive blood sugar detecting method, therefore nothing
Pollution, price are low.
Each embodiment is described by the way of progressive in this specification, what each embodiment stressed be and other
The difference of embodiment, between each embodiment identical similar portion mutually referring to.
In several embodiments provided herein, it should be understood that disclosed method, apparatus and equipment, can be with
Realize by another way.For example, device embodiment described above is only schematical, for example, the unit
Division, only a kind of division of logic function, can there is other dividing mode, such as multiple units or component when actually realizing
Another system can be combined or be desirably integrated into, or some features can be ignored, or do not perform.It is another, it is shown or
The mutual coupling discussed or direct-coupling or communication connection can be by some communication interfaces, between device or unit
Coupling or communication connection are connect, can be electrical, mechanical or other forms.
The unit illustrated as separating component can be or may not be physically separate, show as unit
The part shown can be or may not be physical location, you can with positioned at a place, or can also be distributed to multiple
On NE.Some or all of unit therein can be selected to realize the mesh of this embodiment scheme according to the actual needs
's.In addition, each functional unit in each embodiment of the present invention can be integrated in it is in a processing unit or each
Unit is individually physically present, can also two or more units it is integrated in a unit.
If the function is realized in the form of SFU software functional unit and is used as independent production marketing or in use, can be with
It is stored in a computer read/write memory medium.Based on such understanding, technical scheme is substantially in other words
The part to be contributed to prior art or the part of the technical scheme can be embodied in the form of software product, the meter
Calculation machine software product is stored in a storage medium, including some instructions are causing a computer equipment (can be
People's computer, server, or network equipment etc.) perform all or part of step of each embodiment methods described of the present invention.
And foregoing storage medium includes：USB flash disk, mobile hard disk, read-only storage (ROM, Read-Only Memory), arbitrary access are deposited
Reservoir (RAM, Random Access Memory), magnetic disc or CD etc. are various can be with the medium of store program codes.
The foregoing description of the disclosed embodiments, professional and technical personnel in the field are enable to realize or using the present invention.
A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, it is of the invention
The embodiments shown herein is not intended to be limited to, and is to fit to and principles disclosed herein and features of novelty phase one
The most wide scope caused.
Claims (10)
- A kind of 1. Woundless blood sugar concentration detection method, it is characterised in that including：Spread speed of the ultrasonic wave in target measurement site is determined, determines blood sugar concentration as the first mesh based on the spread speed Mark blood sugar concentration；Target data is obtained, blood sugar concentration is determined as the second target blood glucose concentration based on the target data, wherein, the mesh Mark data be by DATA REASONING unit measure temperature data, humidity data, radiation degrees of data that the target measurement site obtains, Blood oxygen saturation data and pulse rate data；It is determined that acting on the frequency of oscillation of the oscillating circuit of the target measurement site, and blood glucose is determined based on the frequency of oscillation Concentration is as the 3rd target blood glucose concentration；Judge whether the first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration are full The default deviation decision condition of foot, if it is, to first blood sugar concentration, second blood sugar concentration and the 3rd blood Sugared concentration is weighted averagely, obtains final blood sugar concentration data.
- 2. Woundless blood sugar concentration detection method according to claim 1, it is characterised in that described to judge the first object Whether blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration meet default deviation judgement article Part, including：Judge the first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration any two Whether the deviation between person is respectively less than predetermined deviation.
- 3. Woundless blood sugar concentration detection method according to claim 1, it is characterised in that also include：When the first object blood sugar concentration is unsatisfactory for the default deviation decision condition, the determination ultrasound is re-executed For ripple in the spread speed of target measurement site, the step for determining blood sugar concentration based on the spread speed, is multiple, obtains multiple First blood sugar concentration, the multiple first blood sugar concentration is weighted averagely, obtains new first object blood sugar concentration, then Performing judgement first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration is It is no to meet default deviation decision condition；When the second target blood glucose concentration is unsatisfactory for the default deviation decision condition, the acquisition target is re-executed Data, determine that the step for blood sugar concentration is as the second target blood glucose concentration is multiple based on the target data, obtain multiple the Two blood sugar concentrations, the multiple second blood sugar concentration is weighted averagely, obtains the second new target blood glucose concentration, then hold Whether row is described judges the first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration Meet default deviation decision condition；When the 3rd target blood glucose concentration is unsatisfactory for the default deviation decision condition, the determination effect is re-executed In the frequency of oscillation of the oscillating circuit of the target measurement site, and the step for determine blood sugar concentration based on the frequency of oscillation Repeatedly, multiple 3rd blood sugar concentrations are obtained, the multiple 3rd blood sugar concentration is weighted averagely, obtains the 3rd new target Blood sugar concentration, then perform the judgement first object blood sugar concentration, the second target blood glucose concentration and the described 3rd Whether target blood glucose concentration meets default deviation decision condition.
- 4. Woundless blood sugar concentration detection method according to claim 1, it is characterised in that the determination ultrasonic wave is in target The spread speed of measuring point, blood sugar concentration is determined as first object blood sugar concentration based on the spread speed, including：The ultrasonic wave and ultrasonic wave receiving unit sent based on ultrasonic wave transmitting element to the target measurement site is from the mesh The ultrasonic wave that mark measuring point receives determines spread speed of the ultrasonic wave in target measurement site；Determine the phase difference between the ultrasonic wave of the ultrasonic wave and reception sent as target phase difference based on the spread speed；By the target phase difference, determine that the first object blood glucose is dense according to the functional relation of phase difference and blood sugar concentration Degree.
- 5. Woundless blood sugar concentration detection method according to claim 1, it is characterised in that described to be based on the target data Blood sugar concentration is determined as the second target blood glucose concentration, including：Heat exchange metabolic rate is determined by the temperature data, humidity data and radiation degrees of data, and passes through the temperature data Determine CBF；By the heat exchange metabolic rate, the blood oxygen saturation data, the pulse rate data and the CBF, handed over according to heat The functional relation for changing metabolic rate, blood oxygen saturation data, pulse rate data and CBF and blood sugar concentration determines second target Blood sugar concentration.
- 6. Woundless blood sugar concentration detection method according to claim 1, it is characterised in that the determination acts on the mesh The frequency of oscillation of the oscillating circuit of measuring point is marked, and determines blood sugar concentration as the 3rd target blood glucose based on the frequency of oscillation Concentration data, including：Acquisition acts on low frequency signal caused by the oscillating circuit of the target measurement site, and is determined by the low frequency signal The frequency of oscillation；By the frequency of oscillation, determine that the 3rd target blood glucose is dense according to the functional relation of frequency of oscillation and blood sugar concentration Degree.
- 7. a kind of Woundless blood sugar concentration detection device, it is characterised in that comprise at least：Processing unit, ultrasonic measuring device, number According to measuring unit and RC oscillating circuits；The ultrasonic measuring device, for sending ultrasonic wave to target measurement site by ultrasonic wave transmitting element, and pass through Ultrasonic wave receiving unit receives the ultrasonic signal after target measurement site transmission；The DATA REASONING unit, for measuring the target measurement site, obtain temperature data, humidity data, the radiation number of degrees According to, blood oxygen saturation data and pulse rate data；The RC oscillating circuits, for acting on the target measurement site, produce low frequency signal；The processing unit, received for the ultrasonic signal sent based on the ultrasonic wave transmitting element and the ultrasonic wave single The ultrasound information that member receives determines spread speed of the ultrasonic wave in target measurement site, and blood glucose is determined based on the spread speed Concentration is as first object blood sugar concentration；And based on the temperature data, humidity data, radiation degrees of data, blood oxygen saturation Data and pulse rate data determine blood sugar concentration as the second target blood glucose concentration；And based on caused by the RC oscillating circuits Low frequency signal determines frequency of oscillation, and determines blood sugar concentration as the 3rd target blood glucose concentration data based on the frequency of oscillation； And whether judge the first object blood sugar concentration, the second target blood glucose concentration and the 3rd target blood glucose concentration Meet default deviation decision condition, if it is, to the first object blood sugar concentration, the second target blood glucose concentration and The 3rd target blood glucose concentration is weighted averagely, obtains final blood sugar concentration.
- 8. Woundless blood sugar concentration detection device according to claim 7, it is characterised in that the DATA REASONING unit bag Include：Temperature sensor, humidity sensor, radiancy sensor, photo-electric pulse transducer and oxygen saturation measurement unit.
- 9. Woundless blood sugar concentration detection device according to claim 7, it is characterised in that the processing unit is DSP, institute It is TMS320F2812 to state DSP.
- 10. Woundless blood sugar concentration detection device according to claim 7, it is characterised in that also include：Pretreatment unit, Memory cell and display unit；The pretreatment unit, the data for being exported to the DATA REASONING unit pre-process；The memory cell, for storing the data of the processing unit processes；The display unit, the blood sugar concentration data determined for showing the processing unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710859539.6A CN107595318A (en) | 2017-09-21 | 2017-09-21 | A kind of Woundless blood sugar concentration detection method and equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710859539.6A CN107595318A (en) | 2017-09-21 | 2017-09-21 | A kind of Woundless blood sugar concentration detection method and equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107595318A true CN107595318A (en) | 2018-01-19 |
Family
ID=61061828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710859539.6A Pending CN107595318A (en) | 2017-09-21 | 2017-09-21 | A kind of Woundless blood sugar concentration detection method and equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107595318A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108511069A (en) * | 2018-04-12 | 2018-09-07 | 加康有限公司 | Human body physiological parameter detection method, device, storage medium and system |
| CN108836344A (en) * | 2018-04-26 | 2018-11-20 | 深圳市臻络科技有限公司 | Step-length cadence evaluation method and device and gait detector |
| CN109350080A (en) * | 2018-11-28 | 2019-02-19 | 深圳科莱富健康科技有限公司 | A kind of blood glucose monitoring system |
| CN110507331A (en) * | 2019-08-30 | 2019-11-29 | 上海海事大学 | A kind of invasive blood sugar measuring system based on ultrasonic velocity method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102858242A (en) * | 2010-04-27 | 2013-01-02 | 艾迪完整应用有限公司 | Device for non-invasively measuring glucose |
| US20130116513A1 (en) * | 1998-10-05 | 2013-05-09 | Clive Smith | Medical device with communication, measurement and data functions |
| CN204562174U (en) * | 2015-03-27 | 2015-08-19 | 安徽医科大学 | A kind of non-invasive blood-sugar detecting instrument |
-
2017
- 2017-09-21 CN CN201710859539.6A patent/CN107595318A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130116513A1 (en) * | 1998-10-05 | 2013-05-09 | Clive Smith | Medical device with communication, measurement and data functions |
| CN102858242A (en) * | 2010-04-27 | 2013-01-02 | 艾迪完整应用有限公司 | Device for non-invasively measuring glucose |
| CN204562174U (en) * | 2015-03-27 | 2015-08-19 | 安徽医科大学 | A kind of non-invasive blood-sugar detecting instrument |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108511069A (en) * | 2018-04-12 | 2018-09-07 | 加康有限公司 | Human body physiological parameter detection method, device, storage medium and system |
| CN108836344A (en) * | 2018-04-26 | 2018-11-20 | 深圳市臻络科技有限公司 | Step-length cadence evaluation method and device and gait detector |
| CN108836344B (en) * | 2018-04-26 | 2020-12-15 | 深圳市臻络科技有限公司 | Step length step frequency estimation method and device and gait detector |
| CN109350080A (en) * | 2018-11-28 | 2019-02-19 | 深圳科莱富健康科技有限公司 | A kind of blood glucose monitoring system |
| CN110507331A (en) * | 2019-08-30 | 2019-11-29 | 上海海事大学 | A kind of invasive blood sugar measuring system based on ultrasonic velocity method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Siddiqui et al. | Pain-free blood glucose monitoring using wearable sensors: Recent advancements and future prospects | |
| CN104586407B (en) | Multi-parameter physiological indication detection device and detection method thereof | |
| CN107595318A (en) | A kind of Woundless blood sugar concentration detection method and equipment | |
| US8535225B2 (en) | Integrated colligation evaluating device for human body enginery indexes | |
| CN203369905U (en) | Moisture detection system for local skin of human body | |
| US10335061B2 (en) | Methods and apparatus for detecting hand-to-mouth behavior | |
| US9339229B2 (en) | Analyte monitoring devices and methods | |
| CN101194838B (en) | Non-invasive blood sugar detecting instrument | |
| CN204542086U (en) | A kind of intelligent detection and analysis system based on Internet of Things and cloud computing | |
| CN203220371U (en) | Wireless portable noninvasive blood glucose detector | |
| CN104700140B (en) | Multifunctional body is suitable can detection device | |
| CN204203237U (en) | The blood glucose meter that a kind of NFC of support swipes the card | |
| CN106388795A (en) | Intelligent sign monitoring wrist wearable device and blood pressure measuring method | |
| CN106055128A (en) | Mouse module with data acquisition function | |
| CN106344038A (en) | Non-invasive blood glucose measurement system | |
| CN107753036A (en) | A kind of blood information collection monitoring system of real-time update | |
| CN206910338U (en) | A kind of human strength and sign integrated measuring equipment | |
| CN205107649U (en) | Cloud health supervision system of traditional chinese medical science health control cloud platform family | |
| Li et al. | A physical activities healthcare system based onwireless sensing technology | |
| Jain et al. | iGLU 4.0: A continuous glucose monitoring and balancing paradigm with physiological parameters | |
| Cheng et al. | Development of IoT-based simply constructed mobile biomedical signals extraction device | |
| CN207979671U (en) | Portable integrated multi-parameter physiology signal detection device | |
| CN108720845A (en) | A kind of noninvasive dynamics monitoring Intelligent bracelet | |
| CN108720846A (en) | A kind of diabetes Non-invasive detection Intelligent bracelet | |
| CN108742645A (en) | The portable Optical blood glucose instrument of wristband type universal serial |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180119 |