CN112034009A - Sodium ion corrected erythrocyte volume test system and test method - Google Patents
Sodium ion corrected erythrocyte volume test system and test method Download PDFInfo
- Publication number
- CN112034009A CN112034009A CN202010846536.0A CN202010846536A CN112034009A CN 112034009 A CN112034009 A CN 112034009A CN 202010846536 A CN202010846536 A CN 202010846536A CN 112034009 A CN112034009 A CN 112034009A
- Authority
- CN
- China
- Prior art keywords
- sodium ion
- impedance
- unit
- test
- testing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012360 testing method Methods 0.000 title claims abstract description 118
- 229910001415 sodium ion Inorganic materials 0.000 title claims abstract description 73
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 title claims abstract description 62
- 238000010998 test method Methods 0.000 title claims abstract description 10
- 210000003743 erythrocyte Anatomy 0.000 title description 11
- 210000004369 blood Anatomy 0.000 claims abstract description 74
- 239000008280 blood Substances 0.000 claims abstract description 74
- 238000005534 hematocrit Methods 0.000 claims abstract description 45
- 238000000034 method Methods 0.000 claims description 27
- 238000004364 calculation method Methods 0.000 claims description 12
- 150000002500 ions Chemical group 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 238000001514 detection method Methods 0.000 abstract description 2
- 102000001554 Hemoglobins Human genes 0.000 description 5
- 108010054147 Hemoglobins Proteins 0.000 description 5
- 208000007502 anemia Diseases 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011953 bioanalysis Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 239000012482 calibration solution Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
The invention discloses a sodium ion corrected hematocrit test system and a test method, wherein the system comprises: the sodium ion electrode testing unit is used for measuring the concentration of sodium ions in the blood sample; an impedance testing unit for measuring the impedance of the whole blood of the blood sample; and the calculating unit is connected with the sodium ion electrode testing unit and the impedance testing unit and is used for calculating the hematocrit of the blood sample. In the test of testing the total hematocrit by the impedance electrode, the system is additionally provided with a sodium ion electrode test unit for testing the sodium ion concentration, and the influence of the factor on the whole blood impedance is corrected, so that the accuracy of testing the hematocrit is improved, and the clinical error is avoided. Meanwhile, the test system is simple in structure, high in test speed, convenient to use, low in price and low in HCT detection cost. The testing method has the advantages of small error and high testing efficiency and accuracy.
Description
Technical Field
The invention belongs to the technical field of bioanalysis instruments, relates to a system and a method for testing hematocrit, and particularly relates to a system and a method for testing hematocrit by an impedance method with sodium ion correction.
Background
Hematocrit, also known as Hematocrit (HCT), is a simple method for indirectly reflecting the number and volume of red blood cells by measuring the volume ratio of sinking red blood cells to whole blood after centrifugation and precipitation of a certain amount of anticoagulated whole blood. Combining the red blood cell count and the hemoglobin content, the method can calculate the average value of the red blood cells, is beneficial to the morphological classification of anemia, and has very important significance for the diagnosis of anemia, the fluid infusion of dehydrated patients, the blood rheology and other examination aspects.
The current HCT measuring method mainly comprises a Wen's centrifugation method, a blood cell analyzer measuring method, a hemoglobin derivative indirect empirical calculation method and a direct electrical impedance measuring method. The method has the following technical problems: (1) the Wen's centrifugation method is a classical definition method, but the method cannot completely eliminate the influence of residual plasma, has low precision, cannot be conveniently combined with other methods, has large sample usage amount and is complicated to operate; (2) the hematology analyzer measuring method is to calculate the hematocrit by measuring the red blood cells, the white blood cells and the like, and is mainly calculated by an empirical formula, so that the biological variation can not be measured, in addition, the method needs to use the hematology analyzer to input the calculated value, and the HCT is clinically inconvenient to be independently tested; (3) hemoglobin is measured by a hemoglobin cell derivative indirect empirical calculation method through a spectrum, HCT is calculated through an experimental formula, expensive spectrum equipment is required to be installed clinically, and the hemoglobin cell derivative indirect empirical calculation method is inconvenient to use at one time and high in cost; (4) the direct electrical impedance method is to obtain the value of the hematocrit by measuring the whole blood red blood cells and obtaining the impedance value, but the method is calculated by the red blood cell impedance rule under the normal electrolyte level, and errors or even recognition can be easily caused under the condition of electrolyte disorder.
Disclosure of Invention
Therefore, the invention aims to solve the technical problems, and provides the sodium ion corrected hematocrit test system and the sodium ion corrected hematocrit test method with high precision, low cost and high convenience.
In order to solve the technical problems, the technical scheme of the invention is as follows:
one aspect of the present invention provides a sodium ion corrected hematocrit test system, comprising:
the sodium ion electrode testing unit is used for measuring the concentration of sodium ions in the blood sample;
an impedance testing unit for measuring the impedance of the whole blood of the blood sample;
and the calculating unit is connected with the sodium ion electrode testing unit and the impedance testing unit and is used for calculating the hematocrit of the blood sample.
Preferably, the sodium ion electrode testing unit and the impedance testing unit are also connected with a sample injection unit, and the sample injection unit is connected with the sodium ion electrode testing unit and the impedance testing unit through an injection mechanism.
Preferably, the sodium ion electrode test unit is an ion selective electrode test unit.
Preferably, the impedance testing unit is a two-electrode impedance testing unit or a four-electrode impedance testing unit.
In another aspect, the present invention provides a method for testing hematocrit by the test system, comprising the steps of:
conveying the blood sample to a sodium ion electrode testing unit to test the concentration of sodium ions in the blood sample;
conveying the blood sample to an impedance testing unit, and testing the whole blood impedance value of the blood sample;
the hematocrit of the blood sample was calculated from the sodium ion concentration and the whole blood impedance value.
Preferably, the sodium ion concentration is measured by an ion selective electrode method.
Preferably, the whole blood impedance value is measured by a two-electrode method.
Preferably, the calculation of the hematocrit of the blood sample from the sodium ion concentration and the whole blood impedance value is calculated by the following calculation formula:
HCT＝a0+a1*lnR+a2*ln(R)+a3*lnN+a4*(lnN)2+a5*R/N+a6*(R/N)2(ii) a Wherein R is the impedance value of whole blood, N is the sodium ion concentration, and a0, a1, a2, a3, a4, a5 and a6 are empirical coefficients.
Preferably, in the calculation formula, a 0-4.30286, a 1-0.05928, a 2-0.01932, a 3-1.47925, a 4-0.16018, a 5-8.95838, and a 6-56.32353.
Compared with the prior art, the technical scheme of the invention has the following advantages:
(1) the invention relates to a sodium ion corrected hematocrit test system, comprising: the sodium ion electrode testing unit is used for measuring the concentration of sodium ions in the blood sample; an impedance testing unit for measuring the impedance of the whole blood of the blood sample; and the calculating unit is connected with the sodium ion electrode testing unit and the impedance testing unit and is used for calculating the hematocrit of the blood sample. In the test of testing the total hematocrit by the impedance electrode, the system is additionally provided with a sodium ion electrode test unit for testing the sodium ion concentration, and the influence of the factor on the whole blood impedance is corrected, so that the accuracy of testing the hematocrit is improved, and the clinical error is avoided. Meanwhile, the test system is simple in structure, high in test speed, convenient to use, low in price and low in HCT detection cost.
(2) The test method comprises the following steps: conveying the blood sample to a sodium ion electrode testing unit to test the concentration of sodium ions in the blood sample; conveying the blood sample to an impedance testing unit, and testing the whole blood impedance value of the blood sample; the hematocrit of the blood sample was calculated from the sodium ion concentration and the whole blood impedance value. The method solves the problem that the existing impedance method for testing the hematocrit has errors caused by sodium ion fluctuation, and the impedance method for testing the hematocrit after sodium ion correction can solve the errors caused by the sodium ion fluctuation of a patient and improve the accuracy of the test.
Drawings
In order that the present disclosure may be more readily and clearly understood, reference is now made to the following detailed description of the embodiments of the present disclosure taken in conjunction with the accompanying drawings, in which
Fig. 1 is a schematic diagram of a test system according to embodiment 1 of the present invention.
The reference numbers in the figures denote: 1-sodium ion electrode test unit; 2-an impedance test unit; 3-a calculation unit; 4-sample introduction unit.
Detailed Description
Example 1
The present embodiment provides a sodium ion-corrected hematocrit test system for testing hematocrit values in a blood sample for examining conditions of anemia, hemorheology, etc. of a tester.
The testing system is shown in fig. 1, and includes a sodium ion electrode testing unit 1 for measuring sodium ion concentration in a collected blood sample, an impedance testing unit 2 for measuring whole blood impedance of the collected blood sample, and a calculating unit 3 electrically or signal-connected to the sodium ion electrode testing unit 1 and the impedance testing unit 2, where the calculating unit 2 is configured to receive a sodium ion concentration value measured by the sodium ion electrode testing unit 1 and a whole blood impedance value measured by the impedance testing unit 2, and then calculate a hematocrit value of the blood sample according to a formula. In this embodiment, the sodium ion electrode test unit 1 is an ion selective electrode test unit, the ion selective electrode test unit is used for measurement after being calibrated by a calibration solution, and the sodium ion selective electrode may be made of a glass sensitive material or a PVC sensitive material, and is used in a measurement channel in conjunction with a reference electrode, and after being calibrated, the concentration of sodium ions in whole blood is tested. The impedance test unit 2 is a double-electrode impedance test unit or a four-electrode impedance test unit, and the impedance test unit 2 is used for measurement after being calibrated by an impedance test solution.
Further, the test system still includes and advances kind unit 4, it is 2 to advance kind unit 4, connect respectively in sodion electrode test unit 1 and impedance test unit 2 for the blood sample that will gather pours into sodion electrode test unit 1 and impedance test unit 2 respectively and tests, kind unit 4 with sodion electrode test unit 1 and impedance test unit 2 pass through the syringe and connect.
In human plasma, sodium ions are main electrolytes, the concentration of the sodium ions can directly influence the impedance of a blood sample, and the influence on different HCTs is researched under different sodium ion concentrations, so that a correction system for eliminating the influence of the sodium ion concentration on the impedance of whole blood is obtained. Through in the testing arrangement of impedance electrode test total red blood cell volume, increase sodium ion electrode test unit and carry out the sodium ion concentration test to revise the influence of this factor to whole blood impedance, thereby improved the accuracy of red blood cell volume test, avoided clinical error.
Example 2
This example provides a method for performing a hematocrit test using the system of example 1, comprising the steps of:
the sample introduction unit 4 conveys the collected blood sample to the sodium ion electrode testing unit 1 to test the sodium ion concentration in the blood sample, the sodium ion concentration is tested quickly by an ion selective electrode method, the testing efficiency is high, the speed is high, and the operation is convenient and rapid.
The sample introduction unit 4 conveys the collected blood sample to the impedance testing unit 2, and tests the whole blood impedance value of the blood sample, wherein the whole blood impedance value is tested by a double-electrode method, namely, the impedance at two ends of the blood sample is directly tested by two electrodes.
The calculating unit 3 calculates the hematocrit of the blood sample according to the sodium ion concentration and the whole blood impedance value, a CPU is arranged in the calculating unit 3, the CPU can directly collect the sodium ion concentration and the whole blood impedance value of the blood sample, and the hematocrit of the blood sample is calculated and obtained according to a formula.
The calculation formula adopted by the calculation unit 3 is specifically as follows:
HCT＝a0+a1*lnR+a2*ln(R)+a3*lnN+a4*(lnN)2+a5*R/N+a6*(R/N)2(ii) a Wherein R is the impedance value of whole blood, N is the sodium ion concentration, and a0, a1, a2, a3, a4, a5 and a6 are empirical coefficients.
Wherein a 0-4.30286, a 1-0.05928, a 2-0.01932, a 3-1.47925, a 4-0.16018, a 5-8.95838, and a 6-56.32353.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (9)
1. A sodium ion corrected hematocrit test system comprising:
the sodium ion electrode testing unit is used for measuring the concentration of sodium ions in the blood sample;
an impedance testing unit for measuring the impedance of the whole blood of the blood sample;
and the calculating unit is connected with the sodium ion electrode testing unit and the impedance testing unit and is used for calculating the hematocrit of the blood sample.
2. The sodium ion corrected hematocrit test system of claim 1, wherein the sodium ion electrode test unit and the impedance test unit are further connected with a sample injection unit, and the sample injection unit is connected with the sodium ion electrode test unit and the impedance test unit through an injection mechanism.
3. The sodium ion corrected hematocrit test system of claim 1, wherein the sodium ion electrode test unit is an ion selective electrode test unit.
4. The sodium ion corrected hematocrit test system of claim 1, wherein the impedance test unit is a two-electrode impedance test unit or a four-electrode impedance test unit.
5. A method of testing hematocrit by a test system according to any one of claims 1-4, comprising the steps of:
conveying the blood sample to a sodium ion electrode testing unit to test the concentration of sodium ions in the blood sample;
conveying the blood sample to an impedance testing unit, and testing the whole blood impedance value of the blood sample;
the hematocrit of the blood sample was calculated from the sodium ion concentration and the whole blood impedance value.
6. The test method according to claim 5, wherein the sodium ion concentration is measured by an ion selective electrode method.
7. The test method according to claim 6, wherein the whole blood impedance value is tested by a two-electrode method.
8. The test method according to claim 7, wherein the calculation of the hematocrit of the blood sample from the sodium ion concentration and the whole blood impedance value is calculated by the following calculation formula: HCT ═ a0+ a1 ═ lnR + a2 ═ ln (r) + a3 ═ lnN + a4 · (lnN)2+a5*R/N+a6*(R/N)2(ii) a Wherein R is the impedance value of whole blood, N is the sodium ion concentration, and a0, a1, a2, a3, a4, a5 and a6 are empirical coefficients.
9. The test method as claimed in claim 8, wherein in the calculation formula, a 0-4.30286, a 1-0.05928, a 2-0.01932, a 3-1.47925, a 4-0.16018, a 5-8.95838, and a 6-56.32353.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010846536.0A CN112034009A (en) | 2020-08-21 | 2020-08-21 | Sodium ion corrected erythrocyte volume test system and test method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010846536.0A CN112034009A (en) | 2020-08-21 | 2020-08-21 | Sodium ion corrected erythrocyte volume test system and test method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112034009A true CN112034009A (en) | 2020-12-04 |
Family
ID=73580321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010846536.0A Pending CN112034009A (en) | 2020-08-21 | 2020-08-21 | Sodium ion corrected erythrocyte volume test system and test method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112034009A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113252562A (en) * | 2021-05-24 | 2021-08-13 | 南京仁迈生物科技有限公司 | Erythrocyte volume detection device for chemiluminescence apparatus |
| CN116429837A (en) * | 2023-06-15 | 2023-07-14 | 可孚医疗科技股份有限公司 | Method and system for correcting hematocrit and electrochemical measurement system |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4686479A (en) * | 1985-07-22 | 1987-08-11 | Young Chung C | Apparatus and control kit for analyzing blood sample values including hematocrit |
| US4835477A (en) * | 1986-08-16 | 1989-05-30 | Fresenius Ag | Process for the determination of the hematocrit level of whole blood and apparatus for carrying out the process |
| CN102818822A (en) * | 2011-06-09 | 2012-12-12 | 五鼎生物技术股份有限公司 | Device and method for measuring prothrombin time and hematocrit (HCT%) by analyzing change in reactance in a sample |
| CN107003296A (en) * | 2014-05-23 | 2017-08-01 | 诺尔生物医药有限公司 | Hemolysis test method and system |
| CN108680622A (en) * | 2018-05-23 | 2018-10-19 | 北京乐普医疗科技有限责任公司 | Packed cell volume measures and the method for correction in a kind of electrochemica biological sensor |
| US20200096464A1 (en) * | 2017-07-17 | 2020-03-26 | Hewlett-Packard Development Company, L.P. | Determining hematocrit level of a blood sample |
-
2020
- 2020-08-21 CN CN202010846536.0A patent/CN112034009A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4686479A (en) * | 1985-07-22 | 1987-08-11 | Young Chung C | Apparatus and control kit for analyzing blood sample values including hematocrit |
| US4835477A (en) * | 1986-08-16 | 1989-05-30 | Fresenius Ag | Process for the determination of the hematocrit level of whole blood and apparatus for carrying out the process |
| CN102818822A (en) * | 2011-06-09 | 2012-12-12 | 五鼎生物技术股份有限公司 | Device and method for measuring prothrombin time and hematocrit (HCT%) by analyzing change in reactance in a sample |
| CN107003296A (en) * | 2014-05-23 | 2017-08-01 | 诺尔生物医药有限公司 | Hemolysis test method and system |
| US20200096464A1 (en) * | 2017-07-17 | 2020-03-26 | Hewlett-Packard Development Company, L.P. | Determining hematocrit level of a blood sample |
| CN108680622A (en) * | 2018-05-23 | 2018-10-19 | 北京乐普医疗科技有限责任公司 | Packed cell volume measures and the method for correction in a kind of electrochemica biological sensor |
Non-Patent Citations (3)
| Title |
|---|
| 王慧艳, 任超世: "多频率阻抗法研究血液电特性", 中国生物医学工程学报, no. 03 * |
| 王慧艳，任超世: "一种研究血液电特性的新方法─―多频率阻抗法", 山东生物医学工程, no. 02 * |
| 黄飚, 梁长虹, 张云亭, 周东, 林华欢, 茹光腾, 刘红军, 刘其顺: "星形细胞肿瘤CT灌注成像与肿瘤微血管相关性的研究", 实用放射学杂志, no. 05 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113252562A (en) * | 2021-05-24 | 2021-08-13 | 南京仁迈生物科技有限公司 | Erythrocyte volume detection device for chemiluminescence apparatus |
| CN116429837A (en) * | 2023-06-15 | 2023-07-14 | 可孚医疗科技股份有限公司 | Method and system for correcting hematocrit and electrochemical measurement system |
| CN116429837B (en) * | 2023-06-15 | 2023-09-08 | 可孚医疗科技股份有限公司 | Method and system for correcting hematocrit and electrochemical measurement system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2682324C2 (en) | Haemolysis detection method and system | |
| ES2700100T3 (en) | Compensation based on slope including secondary output signals | |
| CN112034009A (en) | Sodium ion corrected erythrocyte volume test system and test method | |
| CN104697917B (en) | The impedance bioelectrical measurement system anomaly detection method and system combined based on multiple features | |
| US9080939B2 (en) | Method of measuring glycosylated protein proportion by AC impedance method | |
| JP2011257403A (en) | Device and method for measuring prothrombin time and hematocrit by analyzing change in reactance in sample | |
| CN108680622A (en) | Packed cell volume measures and the method for correction in a kind of electrochemica biological sensor | |
| CN103983669A (en) | Detection test piece, detection device and detection method | |
| Cha et al. | A new bioelectrical impedance method for measurement of the erythrocyte sedimentation rate | |
| CN115901885B (en) | Metabolic index detection method, system and electrochemical measurement system | |
| US3772591A (en) | Method and apparatus for analyzing blood properties | |
| EP4124854A1 (en) | Electrochemical detection system, measuring instrument and electrochemical detection method | |
| Schapkaitz et al. | Point-of-care estimation of haemoglobin concentration in all age groups in clinical practice | |
| Tara et al. | Relationship between level of blood sugar and current profile by electrolysis process | |
| RU2749982C1 (en) | Method for continuous monitoring of glucose level in biological body fluid and device for its implementation | |
| CN103713024B (en) | A kind of stable obtaining value method of blood sugar electronic surveying | |
| Smith et al. | An evaluation of the ICA1 ionized calcium analyzer in a clinical chemistry laboratory | |
| EP0870185B1 (en) | Method for testing a cell suspension | |
| CN117990768A (en) | Body fluid measuring method and device and electronic equipment | |
| RU107863U1 (en) | CAMERA FOR MEASURING RED BLOOD INDICATORS BY BIOIMPEDANCE ANALYSIS | |
| CN112557267A (en) | Blood sedimentation detection device and detection method thereof | |
| CN2684196Y (en) | Urine glucose detecting instrument with gustation sensor | |
| CN116026736A (en) | Blood analyzer, blood sedimentation detection assembly for same, and blood sedimentation detection method | |
| Luo et al. | Evaluation of portable glucometers for use in rats | |
| TH2003000541C3 (en) | Hydroquinone Determination Process in Cosmetics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 518000 6 / F, block B, building 10, phase III, Huangtian yangbei Industrial Zone, Huangtian community, Hangcheng street, Bao'an District, Shenzhen City, Guangdong Province (R & D site) Applicant after: SHENZHEN KANGLI BIOLOGICAL MEDICAL Co.,Ltd. Address before: 518000 6th floor, building 10, phase III, yangbei Industrial Zone, Huangtian community, Xixiang street, Bao'an District, Shenzhen City, Guangdong Province Applicant before: SHENZHEN KANGLI BIOLOGICAL MEDICAL Co.,Ltd. |
|
| CB02 | Change of applicant information |