CN112535706A - Medicine and food dual-purpose powder for repairing joints and preparation method and application thereof - Google Patents
Medicine and food dual-purpose powder for repairing joints and preparation method and application thereof Download PDFInfo
- Publication number
- CN112535706A CN112535706A CN202011484916.0A CN202011484916A CN112535706A CN 112535706 A CN112535706 A CN 112535706A CN 202011484916 A CN202011484916 A CN 202011484916A CN 112535706 A CN112535706 A CN 112535706A
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- powder
- medicine
- repairing
- food
- joints
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Classifications
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Abstract
The invention discloses medicinal and edible dual-purpose powder for repairing joints as well as a preparation method and application thereof. Chondroitin sulfate, glucosamine and dimethyl sulfone are used as monarch drugs, cistanche and raspberry which are homologous in medicine and food are used as ministerial drugs, and medicinal and edible Chinese herbal medicines such as morinda officinalis, schisandra chinensis, polygonatum sibiricum and the like are added at the same time, and the medicinal and edible dual-purpose powder for repairing joints is prepared by mixing the materials, and has the advantages of simple preparation method and lower production cost; the application mode is various, and the eating requirements of different patients can be met; the medicine and food dual-purpose powder is pure natural, free of pollution, free of any toxic and side effect, quick in effect taking, wide in applicable population, and has the effects of repairing joints, lightening spots and beautifying muscles. The invention is suitable for preparing the medicinal and edible dual-purpose powder for repairing the joints, and the medicinal and edible dual-purpose powder can be prepared into meal replacement powder, liqueur and other health-care foods for repairing the joints and also can be prepared into non-prescription medicinal preparations which are convenient to eat.
Description
Technical Field
The invention belongs to the field of health preservation and health care, and relates to medicinal and edible powder, in particular to medicinal and edible powder for repairing joints and a preparation method and application thereof.
Background
The swelling and pain symptoms of joints of a human body mainly comprise shoulder, neck, waist and leg pain symptoms caused by scapulohumeral periarthritis, synovitis, rheumatism, rheumatoid arthritis, hyperosteogeny and other pathological changes, are often accompanied by swelling and movement disorder, and show an alternating chronic course of disease attack and alleviation; because the blood circulation of a patient is not smooth, nutrition required by muscles or tissues cannot be conveyed through the blood circulation, the muscles of the patient lack nutrition, the aging is accelerated, the muscle becomes stiff, even joint disability and visceral function failure occur, and the daily life of the patient is seriously influenced.
At present, glucosamine and chondroitin sulfate are mostly adopted in health care products for treating and relieving joint swelling and pain in the market, and the effect is not ideal and is slight after patients take the health care products. Therefore, the development of a health-care product for repairing joints, which has a quick response and no toxic or side effect is urgently needed.
Disclosure of Invention
The invention aims to provide medicinal and edible dual-purpose powder for repairing joints, which is used for the treatment and daily health care of people with deficiency of spleen and kidney qi;
the invention also aims to provide a preparation method of the medical and edible dual-purpose powder for repairing joints;
the invention also aims to provide application of the medicine-food dual-purpose powder for repairing joints.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the medicine-food dual-purpose powder for repairing joints comprises the following raw materials of active ingredients in parts by weight: 400-950 parts of chondroitin sulfate, 400-950 parts of glucosamine, 300-800 parts of dimethyl sulfone, 70-200 parts of cistanche, 80-250 parts of raspberry, 90-200 parts of morinda officinalis, 60-100 parts of semen cuscutae, 50-150 parts of schisandra chinensis, 50-200 parts of radix puerariae, 50-200 parts of rhizoma polygonati and 60-250 parts of astragalus membranaceus.
The invention also provides a preparation method of the medicine-food dual-purpose powder for repairing the joints, which is to weigh the raw materials according to the formula and mix the raw materials uniformly to obtain the medicine-food dual-purpose powder for repairing the joints.
The invention also provides an application of the medicine-food dual-purpose powder for repairing the joints, which is to add the medicine-food dual-purpose powder for repairing the joints into coarse cereal powder and uniformly mix the mixture to obtain meal replacement powder for repairing the joints.
As a limitation of the present invention, the coarse cereal powder is aged coarse cereal powder.
The invention provides a second application of the medicinal and edible powder for repairing joints, which is to soak the medicinal and edible powder for repairing joints in wine to obtain liqueur for repairing joints.
As a limitation of the present invention, the soaking is followed by filtration.
As another limitation of the invention, the alcohol degree is 30-40 degrees.
As a third limitation of the invention, the soaking time is 48-96 h.
As a fourth limitation of the present invention, continuous stirring is required during the soaking process.
The invention provides a third application of the medical and edible dual-purpose powder for repairing joints, and the medical and edible dual-purpose powder for repairing joints is prepared into an over-the-counter pharmaceutical preparation for repairing joints, which can be powder, granules, tablets and capsules.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the technical progress that:
(1) the homology of medicine and food is a strong material basis of health preservation and health care of the traditional Chinese medicine, so-called 'safety basis, the food, the force of the medicine and the effect of the medicine for assisting the food' are supplemented mutually, and the unique advantages of the homology of medicine and food in the health preservation and health care of the traditional Chinese medicine are highlighted; the invention is developed according to the health-care theory of homology of medicine and food;
cloud of the book Jingyue: yin and yang in a person are blood and qi, and yang governs qi, so all qi causes vigorous spirit; yin governs blood, so exuberant blood can lead to strong physique; the key to the health of the human body is 'qi and blood', and all diseases of the human body are caused by the problems of qi and blood; the traditional Chinese medicine considers that: chronic diseases are mainly caused by yang deficiency, and modern people have 'eighty-nine of yang deficiency and one hundred-two of yin deficiency'. The reason for this is: modern life violates the laws of nature, luxurious night life, television, computers, mobile phones, air conditioners, automobiles, big fish meat, Linglan leisure food and the like give people a comfortable life which does not want to exercise, so that wind, cold, dampness, summer heat and toxicity invade the body, and the deficiency of yang and qi is caused;
traditional Chinese medicine often says that: qi is the commander of blood and blood is the mother of qi; qi pushing blood and promoting blood circulation, blood mainly produces qi; qi promoting and blood circulation, qi stagnation and blood stasis, blood stasis blocking blood circulation, qi stagnation and blood stasis, and the disease must emerge; the qi and blood are abundant and smooth to move, so that all diseases can be cured;
based on the reasons, chondroitin sulfate, glucosamine and dimethyl sulfone are used as monarch drugs, cistanche and raspberry which are homologous in medicine and food are used as ministerial drugs, morinda officinalis, schisandra chinensis, polygonatum and other Chinese herbal medicines which are homologous in medicine and food are added, and the medicine-food dual-purpose powder for repairing joints is prepared by reasonable compatibility of the components, wherein the medicine-food dual-purpose raw materials in the formula have the following functions:
chondroitin sulfate: as a monarch drug, provides the function of joint pad, thickens the cartilage and enhances the shock absorption capacity of the joint; increasing synovial fluid volume in the joint; delivering nutrients to the joint; clearing waste in the joint; for neuralgia, arthralgia, arthritis, and scapular arthralgia;
glucosamine: as a monarch drug, the joint cartilage is repaired and joint synovial fluid is induced to generate hard friction between joint surfaces, so that the symptoms of joint pain, swelling, bone friction sound and the like are relieved; used for improving the lubrication of bone joint cartilage and the degeneration of intervertebral disc and scapulohumeral periarthritis fibrocartilage ring;
dimethyl sulfone: as a monarch drug, can eliminate virus, dilate blood vessel, enhance blood circulation, soften tissue, and reduce muscle spasm; can be used for treating arthritis, strengthening tendons and bones, and enhancing physical strength; in addition, the dimethyl sulfone can make skin smooth and muscle soft, and can be used for reducing color spots and beautifying and hairdressing;
cistanche deserticola: as a ministerial drug, the health-care tea has the effects of tonifying kidney and strengthening yang, dispelling wind cold, helping to regulate neuroendocrine and balancing hormone, and is used for helping other herbal medicines to play roles, thereby achieving the effects of enhancing immunity, resisting aging and building body;
raspberry: as a ministerial drug, the product has the effects of tonifying liver and kidney, supporting yang, improving eyesight, benefiting qi, reducing weight, and keeping beard and hair white; can be used for treating kidney deficiency, spermatorrhea, and frequent micturition;
morinda officinalis: has effects in invigorating kidney, supporting yang, dispelling pathogenic wind, and removing dampness, and can be used for treating frequent micturition, rheumatic lumbago and gonalgia, kidney deficiency, soreness of waist and knees, sexual impotence, etc.;
dodder seed: nourishing liver and kidney, protecting liver, improving eyesight, relieving diarrhea, and enhancing immunity, and can be used for increasing bone density, promoting hyaline cartilage repair, and resisting aging;
schisandra chinensis: has effects in invigorating kidney, stopping nocturnal emission, relieving cough and asthma, quenching thirst due to body fluid consumption, tonifying yang, relieving night sweat, treating deficiency cold of spleen and kidney, invigorating primordial qi, and stopping nocturnal emission;
kudzu root: has the effects of improving body condition, eliminating in vivo waste, dilating blood vessel, regulating human body function, improving body condition, resisting aging, and prolonging life, and has certain curative effect on hypertension, hyperglycemia and hyperlipidemia;
rhizoma polygonati: it has effects in invigorating spleen qi and spleen yin, tonifying kidney, replenishing essence, and can be used for treating kidney essence deficiency, waist soreness, leg pain, and foot weakness; in addition, the sealwort also has the functions of reducing blood pressure, blood fat and blood sugar, preventing atherosclerosis, delaying senility and resisting bacteria, and has obvious curative effect on treating diabetes;
astragalus root: has effects of removing toxic substance, promoting granulation, promoting diuresis, relieving swelling, promoting blood circulation, removing blood stasis, invigorating qi, invigorating yang, and strengthening tendons and bones, is an essential qi medicine for invigorating spleen and lung, and can be used for treating qi deficiency, asthenia, arthralgia due to rheumatism, and preventing hemiplegia due to apoplexy;
(2) the invention is obtained by a great amount of research and study of related data and related experiments by the inventor, and the inventor finds that when the arthritis patient takes the glucosamine and chondroitin sulfate products sold on the market, the treatment effect is not ideal, only a certain temporary relieving effect is achieved, and the bone joint is not completely maintained and repaired. Through research, the inventor thinks that the focus reason of arthritis patient is caused by wind, cold, dampness and summer heat in patient's body, in order to make glucosamine, chondroitin sulfate exert its maximum biological efficiency, need to discharge wind, cold, dampness and summer heat in the bone joint, glucosamine, chondroitin sulfate can be absorbed to the bone joint effectively, exert its effects of promoting joint lubrication and thickening bone joint liner, thus reach thorough, effective repairing joint focus, relieve the painful treatment effect of bone joint;
the formula has the advantages that 8 medicinal and edible Chinese herbal medicines such as cistanche, raspberry, dodder and the like are added into glucosamine and chondroitin sulfate, the Chinese herbal medicines can effectively dispel focus factors of wind, cold, dampness and summer-heat and can effectively treat osteoarticular pain, and the Chinese herbal medicines with the functions of medicine and food, glucosamine and chondroitin sulfate have complementary and dual overlapping effects and are beneficial to fully exerting the effects of all raw materials;
(3) the invention particularly adds the dimethyl sulfone, the cartilage in the joint is mainly composed of protein (such as collagen) containing sulfur element, and sulfur is an essential element for synthesizing the collagen, although the dimethyl sulfone is widely existed in fruits, vegetables and grains, the dimethyl sulfone is easy to lose in the processes of storage, transportation and thermal processing (frying, boiling, frying, steaming and the like), in order to meet the demand of an osteoarthritis patient on the dimethyl sulfone, the invention particularly adds the dimethyl sulfone to play the daily maintenance function of the cartilage of the bone joint;
(4) the invention also has the effects of blackening hair, lightening spots, beautifying muscles and delaying aging;
(5) the preparation method is simple and has lower production cost;
(6) the invention has various application modes, can be prepared into health-care foods such as meal replacement powder and cordial for repairing joints, and also can be prepared into non-prescription medicinal preparations which are convenient to eat, thereby meeting the eating requirements of different patients;
(7) the traditional Chinese medicine composition is suitable for a wide range of people, and has good effects (the cure rate reaches 96.5%) and quick response (the effect is taken in the fastest 20 days), and the traditional Chinese medicine composition is taken by people with different symptoms such as swelling and pain of rheumatic leg joints, hand joints, low back pain, leg arthritis pain, lumbar disc herniation, femoral head joint pain, scapulohumeral periarthritis pain, fatigue and weakness (the number of people taking the composition reaches 150);
in conclusion, chondroitin sulfate, glucosamine and dimethyl sulfone are used as monarch drugs, cistanche and raspberry which are homologous in medicine and food are used as ministerial drugs, and Chinese herbal medicines which are homologous in medicine and food, such as morinda officinalis, schisandra chinensis, polygonatum sibiricum and the like are added at the same time, and the medicine and food dual-purpose powder for repairing joints is prepared by mixing, and has the advantages of simple preparation method and lower production cost; the application mode is various, and the eating requirements of different patients can be met; the medicine and food dual-purpose powder is pure natural, free of pollution, free of any toxic and side effect, quick in effect taking, wide in applicable population, and has the effects of repairing joints, lightening spots and beautifying muscles.
The invention is suitable for preparing the medicinal and edible dual-purpose powder for repairing the joints, and the medicinal and edible dual-purpose powder can be prepared into meal replacement powder, liqueur and other health-care foods for repairing the joints and also can be prepared into non-prescription medicinal preparations which are convenient to eat.
Detailed Description
The following specific examples further illustrate the invention but are not intended to limit the invention thereto.
Example 1 preparation method of medicinal and edible powder for repairing joints
The embodiment is a preparation method of medicinal and edible powder for repairing joints, which is carried out according to the following steps: weighing 950g of chondroitin sulfate, 950g of glucosamine, 500g of dimethyl sulfone, 200g of cistanche, 250g of raspberry, 200g of morinda officinalis, 100g of dodder, 150g of schisandra chinensis, 200g of kudzuvine root, 200g of rhizoma polygonati and 250g of astragalus, and mixing to obtain the medicine-food dual-purpose powder for repairing joints, which is marked as Z1.
The raw materials are all fine particles and are directly purchased in the market.
Example 2-8 preparation method of medicinal and edible powder for repairing joints
Embodiments 2 to 8 are respectively a preparation method of medicinal and edible powder for repairing joints, the preparation method is basically the same as that of embodiment 1, and the differences are only in the use amount of raw materials, and the following table specifically shows:
table 1 summary of the raw material amounts and process parameters in examples 2 to 8
EXAMPLE 9 therapeutic examples
0.2kg of the edible and medicinal dual-purpose powder Z1-Z2 provided in examples 1-2 is respectively added into 3.8kg of coarse cereal powder L1 (a mixture of 0.7kg of black sesame powder, 0.7kg of black rice powder, 0.6kg of coix seed powder, 0.6kg of glutinous rice powder, 0.6kg of black bean powder and 0.6kg of red bean powder) and 3.7kg of coarse cereal powder L2 (a mixture of 0.8kg of black sesame powder, 0.8kg of black rice powder, 0.6kg of coix seed powder, 0.6kg of corn starch, 0.6kg of black bean powder and 0.4kg of red bean powder), and the mixture is uniformly mixed to prepare meal replacement powder Y1-Y2.
Respectively weighing 2kg of the medicinal and edible powder Z3-Z6 provided in embodiments 3-6, respectively adding into 100L of wine J3-J6, soaking and stirring (wherein wine J3 is 30 degrees, wine J4 is 32 degrees, wine J5 is 38 degrees, and wine J6 is 40 degrees); wherein Z3 does not need to be filtered, and Z4-Z6 need to be filtered (Z4 is soaked for 48 hours, Z5 is soaked for 72 hours, and Z6 is soaked for 96 hours and then filtered), so that the liqueurs Y3-Y6 are respectively prepared.
Respectively pulverizing the medicinal and edible powder Z7 provided in example 7 into fine powder, sieving with a 80-mesh sieve, drying, and hermetically packaging with an aluminum foil bag (with an effective component content of 0.6 g/bag) to obtain non-prescription Chinese medicinal powder Y7;
the medicinal and edible powder Z8 provided in example 8 is respectively ground into fine powder, sieved by a 80-mesh sieve, dried and encapsulated (the content of active ingredients is 0.65 g per granule), and then the non-prescription traditional Chinese medicine capsule Y8 is prepared.
Meanwhile, the medicine-food dual-purpose powder for repairing joints can also be prepared into other non-prescription pharmaceutical preparations in any form, such as granules, tablets and the like.
Typical cases are:
1. daidan, women, 50 years old, Hebei Pingshan
The pain of waist and leg arthritis is more than ten years, the patient often wakes up when sleeping at night, still drinks are often flowing, the patient is afraid of standing even when suffering from the pain of legs in the morning, the effect cannot be seen when taking various medicines, and the patient takes the glucosamine tablets bought from a pharmacy afterwards, so that the effect is good when the patient starts to take the glucosamine tablets, and the patient can use the glucosamine tablets after taking the glucosamine tablets for half a month; the Chinese medicinal powder Y7 of the powder for medicine and food with the functions of maintaining and repairing bone and joints is eaten in 8 months in 2019, the pain is obviously relieved when people eat the powder for medicine and food for about 25 days, the people can stand in the morning, the pain part is hot and has a feeling of jumping, the people do not feel painful and awake at night, and when the powder is taken for about 5 months, the pain in the waist and the legs disappears completely.
The usage method comprises the following steps: it is taken orally with water 3 times a day, 1 bag each time.
2. The man in 64 years old and the Chang' an district in Shijiazhuang city
Leg pain and knee joint pain caused by walking are not improved after a plurality of medicines and health care products are eaten, 100 ml of cordial Y5 made of medical and edible dual-purpose powder for maintaining and repairing bone joints is drunk in 2019 in 9 months, walking knees are basically not softened and pain is relieved after drinking the wine for half a month, and leg pain and knee joint pain are not painful at all and legs are also strong when the wine is drunk for about 3 months.
3. Zhang-a, woman, age 50, peasant, Shandong Wen Shang Tun Zhen
Lumbago, leg pain, cervical vertebra pain, body weakness, scapulohumeral periarthritis for five or six years, and patients who visit different hospitals have not improved. Meal replacement powder Y1 of medicine and food dual-purpose powder for maintaining and repairing bone and joints is eaten at 8 months in 2019, 40g of meal replacement powder is eaten each day, more than 20 days are eaten, pain of waist and scapulohumeral periarthritis begins to be relieved, half a year is eaten, the waist, the legs, the cervical vertebra and the scapulohumeral periarthritis are not painful, the body is particularly strong at present, and the skin is smooth.
4. Jiangzhi, women, 51 years old, Shijiazhuang Gao city people
The pain of leg joints and hand joints caused by rheumatism sometimes fails to walk for more than ten years, and a plurality of doctors and questioning medicines are not good, the meal replacement powder Y2 of the medicine and food dual-purpose powder for maintaining and repairing bone joints is taken in 7 months in 2019, 40g is taken every day, after 1 month of taking, the body feels strenuous, after 2 months of taking, the pain of the leg joints and the hand joints caused by rheumatism is obviously relieved, and after about 4 months of taking, the pain basically disappears, so that the people can take care of life.
5. Li Yi, Man, 46 years old, Shandong Zibo
The lumbar intervertebral disc protrusion is very painful sometimes, particularly in cloudy days, the patient is difficult to stand up after sitting down, is difficult to sit down after standing up, is difficult to go upstairs and go downstairs, and is difficult to feel painful, and the patient is always taking glucosamine and chondroitin products after three years of illness, and the patient starts to feel painful after stopping taking for several days. In 2019, in 9 months, through introduction of friends, meal replacement powder Y1 of medicine and food dual-purpose powder for maintaining and repairing bone and joints is taken, 40g of meal is taken every day, the meal replacement powder starts to obviously improve after being taken for 25 days, pain basically disappears after the meal replacement powder is taken for five months, the meal replacement powder is strong in all directions, people can go upstairs and downstairs and live by themselves, and the meal replacement powder is still taken at present.
6. Liu Yi in Liu Wu, Man, age 55, retired, Shandong Linyi City
The right leg femoral head arthralgia cannot be dried and alive, the disease condition is aggravated in the morning, the patient cannot walk, and no obvious effect is achieved when the patient takes medicines and takes injection, through introduction, meal replacement powder Y2 of medicine and food dual-purpose powder with the functions of maintaining and repairing bone joints is taken in 10 months in 2019, 40g of the meal replacement powder is taken every day, pain is relieved after the meal replacement powder is taken for 20 days, the patient can walk freely after taking the meal replacement powder for 5 months, and the meal replacement powder is still taken for consolidation as if the patient had no disease.
7. Chen-A, woman, 59 years old, Henan Anyang city
The pain and swelling of the joints of two legs and the small joints of two hands are reduced, 40g of meal replacement powder Y1 with dual-purpose powder for maintaining and repairing bone joints and medicine and food is taken in 10 months in 2019 every day, the pain of the joints begins to be relieved after the meal replacement powder Y1 is taken for 12 days, when the meal replacement powder Y is taken for 3 months, the pain disappears, and the swollen small joints are relieved and cured.
8. One in 59 years old, Shandong Jinan City, Onye, Ye
For three years, the pain of scapulohumeral periarthritis, the arm can not be lifted, the cramp and the common cold are favored, and the chondroitin sulfate and glucosamine tablets are eaten for nearly one year, and are slightly relieved, but the pain and the cramp are still realized; the cordial Y3 containing medicinal and edible powder for maintaining and repairing bone and joint is drunk at 4 months in 2020, 100 ml is drunk every day, pain is obviously relieved after 20 days, scapulohumeral periarthritis is not painful when drinking 5 months, leg cramp is avoided, and cold is rarely caused.
9. Ten-in-ten people in Changan district of Shijiazhuang city of 72 years old
In 2016, femoral head pain is suffered, people need to support the bone and go upstairs and downstairs, the bone and the thighbone are limp, the traditional Chinese medicine is not improved after being eaten for a year, chondroitin sulfate and glucosamine tablets which are nearly a year are eaten, the effect cannot be achieved after the chondroitin sulfate and the glucosamine tablets are used for sensory treatment and are continuously taken, and the thighbone is still painful. The wine Y4 which is a medical and edible powder for maintaining and repairing bone and joints is drunk in 4 months in 2020, the wine is drunk 100 ml every day, the pain is relieved after 35 days, the pain of the femoral head is not relieved after about 7 months, people are not used for assisting when going upstairs, the life can be completely self-care, the senile plaque on the arm is eliminated, and the wine is still drunk for a period of time at present.
10. Jie-Yi, woman, 55 years old, Chang' an district in Shijiazhuang City
The Chinese and western medicine and glucosamine tablets are taken for a few years after people walk with the rheumatic arthritis for 5 years and always carry one stool by hand and take three five hundred meters, but the Chinese and western medicine and glucosamine tablets are not improved all the time, the meal replacement powder Y2 of the medicine and food dual-purpose powder for maintaining and repairing bone joints is eaten beginning in 5 months in 2020, 40g each day, the legs are not painful after eating for three months, and the skin becomes fine, smooth and smooth.
11. Xie one, man, 53, Hebei Xinji City
The patients with the rheumatic arthritis have more than 7 years, leg pain and inconvenient movement, the patients do not get better after taking the traditional Chinese medicine for more than a year, and then take the collagen and the glucosamine tablets instead, although the pain is relieved, the pain is recovered after taking the traditional Chinese medicine for one time; the cordial Y6 containing powder for both medicine and food for maintaining and repairing bone and joint is taken at 6 months in 2020, 100 ml is taken every day, joint pain is relieved after 20 days, when the wine is taken for 5 months, walking is not painful, and self-feeling is cured after one month.
12. Li Yi, woman, 52 years old, Shandong Haiyang City
In 2017, the lumbar intervertebral disc is suddenly protruded, the skin of the whole body has small red spots, the pruritus is difficult to fall asleep, the pain is relieved by hospital traction treatment, but the skin is still pruritus due to frequent repetition, the traditional Chinese medicine is eaten later, the pruritus still frequently recurs, the traditional Chinese medicine capsule Y8 is taken in 5 months in 2020, the pain of the intervertebral disc is relieved after the traditional Chinese medicine capsule is taken for one month, the intervertebral disc has no obvious pain when the traditional Chinese medicine capsule is eaten for 7 months, the small red spots of the skin completely disappear, the skin is not itchy, and the rough skin becomes fine and smooth.
The usage method comprises the following steps: it is administered with 1 granule of boiled water 3 times a day.
The medicine and food dual-purpose powder provided by the invention can be used for preparing different meal replacement powder for repairing joints, liqueur and other health-care foods according to requirements, and can also be prepared into non-prescription pharmaceutical preparations (the form can be powder, granules, tablets and capsules) which are convenient to eat, the typical cases are only for illustrating the administration effect, and the preparation processes of tablets and granules which are not illustrated all adopt conventional tablet/granule excipients (generally including fillers (such as starch, lactose, dextrin, powdered sugar, calcium sulfate, sucrose, mannitol, microcrystalline cellulose, glucose and the like), binders (such as starch slurry, pregelatinized starch, dextrin, povidone, ethyl cellulose, hydroxypropyl cellulose and the like), wetting agents (such as distilled water, ethanol and the like) to prepare the tablets/granules by a conventional method, and are not described again.
Example 10 acute oral toxicity test
The medicinal and edible powder Z1 provided in example 1 is subjected to an acute oral toxicity test, and the test process is as follows:
1. procedure of experiment
1.1 Experimental animals:
SPF grade KM mice, body weight: 18g to 22g, 20 in total, and female and male halves. Provided by sbeft (beijing) biotechnology limited, the production license number: SCXK (Jing) 2019-.
Animal feeding management conditions: the temperature is 20-26 ℃, the relative humidity is 40-70%, and the illumination is 12h and alternating light and shade. The water was freely drunk and fed with standard block-shaped maintenance feed (purchased from Sibefu (Beijing) Biotechnology Co., Ltd., product license number: SCXK (Beijing) 2019-.
1.2 main instruments and reagents:
MP3KC electronic balance (IE-3482), JY3003 electronic balance (IE-3487).
1.3 test methods:
the test subjects were orally administered to test mice (10 male and female, respectively) once by a limited test method. The gavage dose was 10000mg/kg BW.
The tested substances are prepared on site when used, 10.00g of medicinal and edible powder Z1 sample is weighed, deionized water is added to 20.0mL, and the mixture is fully and uniformly mixed for later use. The test substance is fasted for 4 hours before being given to the mouse, water is not forbidden, the test is weighed and marked on the day, the intragastric administration volume is 20mL/kg BW, the test substance is given to the mouse through oral intragastric administration once, and the feed is given to the test substance of the mouse after 2 hours. After the test substance is given, the observation is continuously carried out for 2-4 h, and then the observation is carried out for 1 time every day, wherein the observation period is 14 days.
Oral toxicity of the test substance is determined by observing the presence or absence of animal mortality associated with the test substance, and determining whether subsequent testing using the Haemon method is necessary. Mice were recorded for signs of intoxication, appearance and disappearance of symptoms, and time of death of the animals.
2. Results
2.1 manifestation of poisoning: after the test substance is given, the experimental animal has no obvious toxic sign.
2.2 death and body weight: animal mortality and body weight records are shown in tables 2 and 3, respectively:
TABLE 2 acute toxicity test results
| Dosage (mg/kg BW) | Sex | Animal number (only) | Number of dead animals |
| 10000 | Female part | 10 | 0 |
| 10000 | Male part | 10 | 0 |
TABLE 3 weight change in animals tested for acute toxicity
| Dosage (mg/kg BW) | Sex | Before test (g) | Day 7 (g) | Day 14 (g) |
| 10000 | Female part | 19.2±0.9 | 26.6±1.2 | 33.9±1.7 |
| 10000 | Male part | 20.6±0.9 | 30.2±1.1 | 40.0±1.6 |
From the above results, it can be seen that the edible and medicinal powder of the present invention provides half of the Lethal Dose (LD) for KM female and male mice50) The BW is more than 10000mg/kg, and the medicine-food dual-purpose powder belongs to actual nontoxic grade according to the grading standard of the dose of an acute oral toxicity test of the national standard for food safety of GB 15193.3-2014, which shows that the medicine-food dual-purpose powder has no toxic or side effect on human bodies.
Although the present invention has been described in detail with reference to the above embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described above, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.
Claims (10)
1. The medicine-food dual-purpose powder for repairing joints is characterized in that the raw materials for preparing the effective components of the powder in parts by weight comprise: 400-950 parts of chondroitin sulfate, 400-950 parts of glucosamine, 300-800 parts of dimethyl sulfone, 70-200 parts of cistanche, 80-250 parts of raspberry, 90-200 parts of morinda officinalis, 60-100 parts of semen cuscutae, 50-150 parts of schisandra chinensis, 50-200 parts of radix puerariae, 50-200 parts of rhizoma polygonati and 60-250 parts of astragalus membranaceus.
2. The method for preparing a powder used as both medicine and food for repairing joints as claimed in claim 1, wherein the powder used as both medicine and food for repairing joints is obtained by mixing all the raw materials.
3. The use of the powder for both medicine and food for repairing joints as claimed in claim 1, wherein the powder for both medicine and food for repairing joints is added to coarse cereal powder, and mixed to obtain meal replacement powder for repairing joints.
4. The use of the powder as both medicine and food for repairing joints according to claim 3, wherein the coarse cereal powder is a cured product.
5. The use of the powder for both medicine and food for repairing joints as claimed in claim 1, wherein the powder for both medicine and food for repairing joints is added to wine and soaked to obtain liqueur for repairing joints.
6. The use of the powder as both medicine and food for repairing joints as claimed in claim 5, wherein the liqueur for repairing joints is further filtered.
7. The use of the powder as both medicine and food for repairing joints according to claim 5, wherein the alcohol has a degree of 30-40 °.
8. The application of the dual-purpose powder used as both medicine and food for repairing joints as claimed in claim 5, wherein the soaking time is 48-96 h.
9. The use of the powder for both medicine and food for repairing joints according to any one of claims 5 to 8, wherein the soaking process requires continuous stirring.
10. The use of the powder for both food and medicine for repairing a joint as set forth in claim 1, wherein the powder for both food and medicine for repairing a joint is prepared as an over-the-counter pharmaceutical preparation for repairing a joint.
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