CN112516234A

CN112516234A - A Chinese medicinal composition

Info

Publication number: CN112516234A
Application number: CN202011613857.2A
Authority: CN
Inventors: 白丽; 张铭华; 麦雨沛
Original assignee: Taizhou Huayu Health Management Co ltd
Current assignee: Taizhou Huayu Health Management Co ltd
Priority date: 2020-12-31
Filing date: 2020-12-31
Publication date: 2021-03-19

Abstract

The invention relates to a traditional Chinese medicine composition which comprises the following components in percentage by mass: 25-40% of guava leaves, 5-12% of selenium-rich powder, 4-10% of Chinese yam, 6-10% of hawthorn, 5-9% of wolfberry, 7-9% of astragalus membranaceus, 6-8% of kudzu roots, 7-10% of lotus leaves, 7-10% of mulberry leaves and 3-6% of liquorice. The traditional Chinese medicine composition has the effects of regulating spleen and stomach, reducing high blood pressure, high blood sugar and high blood fat and killing helicobacter pylori.

Description

A Chinese medicinal composition

Technical Field

The invention relates to a traditional Chinese medicine composition and a preparation method thereof, belonging to the technical field of medical health products.

Background

Modern people can easily get the spleen and stomach diseases, which belong to chronic diseases and are difficult to radically treat repeatedly. The spleen and stomach are transportation and transformation, which are closely related to diet and living habits. Modern people have fast pace of life and irregular diet. The eating habits are relatively poor. Overeating and eating too hard and cool. Especially, people like drinking cold beverages in summer, which is very bad for the spleen and stomach; in addition, modern life rhythm is fast, the pressure is big, the spirit is often in the state of tension, it is bad to stomach; and the spleen is often damaged by staying up all night and excessive thinking. It is liked to be pungent and pungent, smoking and drinking, and mental stress can induce peptic ulcer, acute and chronic gastritis.

In addition, helicobacter pylori infection is also a major cause. Helicobacter pylori is a gram-negative bacterium with a spiral shape, micro-anaerobic property and strict requirements on growth conditions, is the only microorganism species known to live in human stomach, and 67-80% of gastric ulcer and 95% of duodenal ulcer are caused by helicobacter pylori. The common symptoms of patients with chronic gastritis and peptic ulcer are: after eating, the upper abdomen is full, uncomfortable or painful, and often accompanied by other adverse symptoms, such as belching, abdominal distension, acid regurgitation, anorexia, halitosis, etc. Some patients can also have recurrent severe abdominal pain, small amount of upper gastrointestinal hemorrhage, etc., which can seriously cause the canceration of the stomach. Helicobacter pylori propagates mainly in the "mouth-mouth" mode and in the "feces-mouth" mode. Helicobacter pylori infection is usually treated by triple therapy or quadruple therapy, but has the defects of drug resistance and great side effect on antibiotics and great harm to the stomach and the intestine.

Meanwhile, the three highs of modern people are more. Three highs are the general term for hyperglycemia, hyperlipidemia and hypertension. Hyperglycemia is a pathological change which is independent in a human body and has the characteristic that the content of glucose in blood of the human body is higher than a normal value, a diseased part is in the blood, and the nature of the disease is blood sugar metabolism disorder. The clinical manifestations of hyperglycemia can have dominant symptoms, such as thirst, much drinking water, much urine and emaciation; may be an implicit symptom without significant subjective discomfort. Hyperlipidemia refers to the condition of high blood cholesterol or triglyceride or low high-density lipoprotein cholesterol, and is called as dyslipidemia in modern medicine. It is a main factor causing atherosclerosis and is a risk factor for occurrence and development of cardiovascular and cerebrovascular diseases. Hypertension refers to the condition of higher than normal blood pressure in the circulatory system, usually refers to the increase of blood pressure in the systemic circulation arteries, and is a common clinical syndrome. The three high diseases can cause cardiovascular and cerebrovascular diseases, and the cardiovascular and cerebrovascular diseases have the characteristics of high morbidity, high disability rate, high mortality rate, high recurrence rate and more complications. The world health organization has clearly proposed that the first line of defense against cardiovascular and cerebrovascular diseases is to reduce and control three highs.

Disclosure of Invention

The invention aims to solve the problems and provides a traditional Chinese medicine composition for regulating spleen and stomach, reducing high blood pressure, high blood sugar and high blood fat and killing helicobacter pylori and a preparation method of the traditional Chinese medicine composition.

The invention provides a technical scheme for solving the problems, which comprises the following steps: a traditional Chinese medicine composition comprises the following components in percentage by mass: 25-40% of guava leaves, 5-12% of selenium-rich powder, 4-10% of Chinese yam, 6-10% of hawthorn, 5-9% of wolfberry, 7-9% of astragalus membranaceus, 6-8% of kudzu roots, 7-10% of lotus leaves, 7-10% of mulberry leaves and 3-6% of liquorice.

The selenium-rich powder is selenium-rich edible fungus powder, and the content of organic selenium in the selenium-rich powder is 200-400 mug/g.

The guava leaf is 30-38% by mass.

The selenium-enriched powder accounts for 6-10% by mass.

The Chinese yam is 5-9% by mass, the hawthorn is 7-9% by mass, and the wolfberry is 6-8% by mass.

The Chinese medicinal composition can be made into tablet, capsule, oral liquid, buccal agent, granule, potion, pill, and powder.

The beverage is brewing beverage.

The invention provides another technical scheme for solving the problems, which comprises the following steps: a preparation method of a potion of a traditional Chinese medicine composition comprises the following steps:

A. cleaning folium Psidii Guajavae, folium Nelumbinis and folium Mori respectively, sterilizing, deactivating enzyme, oven drying, and kneading to obtain folium Camelliae sinensis, cleaning rhizoma Dioscoreae, fructus crataegi, fructus Lycii, radix astragali, radix Puerariae and Glycyrrhrizae radix respectively, sterilizing, oven drying, slicing, and pulverizing to obtain powder;

B. mixing the prepared tea leaves and powder with selenium-rich powder;

C. soaking with water at 90-100 deg.c for 10-20 min.

B. mixing the prepared tea leaves and powder with selenium-rich powder;

C. decocting the mixture for 10 to 20min by slow fire.

The invention provides another technical scheme for solving the problems, which comprises the following steps: a preparation method of a traditional Chinese medicine composition comprises the following steps:

A. cleaning guava leaf, lotus leaf and mulberry leaf, sterilizing, deactivating enzyme, drying and pulverizing into powder, respectively, cleaning, sterilizing, drying, slicing and pulverizing rhizoma Dioscoreae, fructus crataegi, fructus Lycii, radix astragali, radix Puerariae and Glycyrrhrizae radix into powder;

B. mixing the obtained powder with selenium-rich powder,

C. the mixed powder is used as raw material to prepare the required dosage form.

Guava leaves, bitter and astringent in taste, neutral in nature, enter large intestine meridian, and have the effects of eliminating dampness, strengthening spleen, clearing heat and removing toxicity. It is commonly used for diarrhea, dysentery, abdominal distention, gingival swelling and pain, rheumatic arthralgia, eczema, ecthyma, furuncle, toxic swelling, traumatic injury, traumatic hemorrhage, and snake and insect bite. The pharmacological actions are antibacterial, hypoglycemic and cancer-preventing.

The selenium-rich edible fungus powder is obtained by culturing organic selenium in edible fungus by biotransformation technology. Selenium is a necessary trace element for human bodies, and a large number of clinical experiments at home and abroad prove that the lower the selenium content in the human bodies, the higher the possibility of stomach diseases. The selenium content in the body of the patient with superficial gastritis is usually lower than that of the healthy person, the canceration possibility of the patient with atrophic gastritis with low selenium content in blood is greatly increased, and most of the patients with gastric cancer are in a selenium deficiency state. The reduction of selenium level in human body can cause the immune function deficiency and the oxidation resistance reduction, which cause the instability of gastric mucosa barrier, and the xanthine oxidase can continuously rise under emergency condition, which causes the ischemic injury of gastric mucosa, and the increase of oxygen free radical, which causes the pathological changes of digestive system such as gastritis and gastric ulcer. Selenium is a natural antioxidant, and can effectively inhibit the generation of active oxygen, scavenge free radicals generated in the metabolic process of a human body, prevent gastric mucosa necrosis, promote mucosa repair and ulcer healing, and prevent canceration. The generation of cardiovascular and cerebrovascular diseases is related to lipid peroxidation in vivo, and selenium can remove the lipid peroxidation, protect the integrity of cell membrane on arterial vessel wall, prevent atherosclerosis, reduce thrombosis, and prevent myocardial infarction. Selenium can regulate cholesterol and triglyceride in body, reduce blood viscosity, and prevent cardiovascular and cerebrovascular diseases by virtue of its strong antioxidant function. The selenium supplement for the diabetics can protect and repair islet cells from being damaged, maintain the normal function of secreting insulin, allow the islet cells to regulate and control blood sugar by themselves, and clear free radicals, so that the main way of preventing and treating the diabetes and the complications of the diabetes is provided. After the selenium supplement, the selenium supplement of the diabetic can improve the oxidation resistance of the organism, protect the membrane structure of cells and keep the functions of normal secretion and insulin release of pancreatic endocrine cells.

Yam, sweet in flavor and neutral in nature, enters lung, spleen and kidney meridians. To invigorate the spleen, tonify the lung, strengthen the kidney and replenish vital essence. Has effects in invigorating spleen, nourishing stomach, promoting salivation, tonifying lung, and tonifying kidney. Can improve immunity, and can be used for treating diabetes, hyperlipemia, and hypertension.

Haw, sour and sweet in flavor, warm in nature, enters spleen, stomach and liver meridians. Promoting digestion, invigorating stomach, promoting qi circulation, removing blood stasis, eliminating turbid pathogen, and reducing blood lipid. Has effects in dilating blood vessel, increasing coronary artery blood flow, lowering blood pressure and blood lipid, and preventing and treating cardiovascular and cerebrovascular diseases.

Gou Qi Zi is sweet in flavor and neutral in nature, entering liver and kidney meridians. Nourish kidney, moisten lung, tonify liver, improve vision. Can improve immunity and treat hypertension and diabetes.

Monarch drug: guava leaves, selenium-rich powder, Chinese yam, hawthorn and wolfberry. The Chinese yam, the hawthorn and the wolfberry fruit have mild nature, are mainly nourished, and play roles in harmonizing spleen and stomach, soothing liver and regulating qi. The guava leaves have the effects of clearing away heat and toxic materials, killing various cocci and bacilli, and improving gastric mucosa inflammation cell infiltration, reducing chronic damage to gastric mucosa, improving gastric mucosa microcirculation, and enhancing mucosa repair capacity when used together with the selenium-rich powder, so that the existing environment of helicobacter pylori is influenced, and the guava leaves have an inhibiting effect on helicobacter pylori.

Huang Qi is sweet in flavor and slightly warm in nature, entering spleen and lung meridians. Tonify qi, strengthen superficies, expel toxin, expel pus, induce diuresis, and promote granulation. Has effects in dilating blood vessel, lowering blood pressure, preventing and treating diabetes, and improving disease resistance.

Kudzuvine root, sweet and pungent in flavor, cool in nature, enters lung and stomach meridians. Expelling pathogenic factors from muscles and skin, bringing down fever, promoting eruption, promoting the production of body fluid, quenching thirst, invigorating yang, and relieving diarrhea. Has effects in dilating coronary artery and cerebral vessels, increasing coronary artery blood flow and cerebral blood flow, reducing myocardial oxygen consumption, increasing oxygen supply, and lowering blood pressure and blood sugar.

Lotus leaf, with bitter taste and neutral nature, enters liver, spleen and stomach meridians. Clearing away summer-heat, calming liver and reducing blood fat. Has effects in dilating blood vessel, increasing coronary artery blood flow, lowering blood pressure and blood lipid, and preventing and treating cardiovascular and cerebrovascular diseases.

Mulberry leaf, folium Mori, bitter and sweet in taste, cold in nature, enters lung and liver meridians. Disperse wind-heat, clear lung-heat and moisten dryness, pacify liver and improve vision, cool blood and stop bleeding. Has effects in lowering blood sugar, lowering blood pressure, inhibiting bacteria, and resisting virus.

Licorice root, radix Glycyrrhizae is sweet in flavor and neutral in nature, and enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs.

Ministerial drugs: the lotus leaf, the mulberry leaf, the kudzuvine root, the astragalus and the liquorice, the kudzuvine root, the lotus leaf, the mulberry leaf and the liquorice clear away heat and toxic materials, the astragalus can improve the disease resistance, is beneficial to enhancing the drug effect, has the effects of reducing blood pressure, blood fat and blood sugar, and is particularly suitable for people who suffer from chronic gastropathy for a long time, have irregular daily work and rest, are disordered in diet and have three high symptoms at the same time.

The invention has the positive effects that: the traditional Chinese medicine composition disclosed by the invention is prepared from natural green edible traditional Chinese medicine components, and five monarch drugs and five ministerial drugs are matched for use, so that the traditional Chinese medicine composition has the effects of regulating spleen and stomach, synergistically reducing three highs and is beneficial to treatment of helicobacter pylori. The traditional Chinese medicine composition disclosed by the invention has the advantages of medicine and food dual purposes, mild medicine property and small toxic and side effects, can be prepared into different medicaments for taking, can also be prepared into tea for long-term drinking, is wide in applicable population, integrates treatment and health care, and is particularly suitable for treating chronic gastropathy.

Detailed Description

The present invention is described in detail below by way of examples, it should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and those skilled in the art can make some insubstantial modifications and adaptations of the present invention based on the above-described disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.

Example 1

The brewing tea of the traditional Chinese medicine composition comprises the following components: 3.4g of guava leaves, 0.8g of selenium-rich edible fungus powder, 0.7g of Chinese yam, 0.8g of hawthorn, 0.7g of medlar, 0.8g of astragalus membranaceus, 0.7g of kudzu root, 0.8g of lotus leaves, 0.8g of mulberry leaves and 0.5g of liquorice. The content of organic selenium in the selenium-rich powder is 400 mug/g.

The preparation method of the traditional Chinese medicine composition brewing tea comprises the following steps:

A. cleaning folium Psidii Guajavae, folium Nelumbinis and folium Mori respectively, sterilizing, deactivating enzyme, oven drying, and kneading to obtain folium Camelliae sinensis, cleaning rhizoma Dioscoreae, fructus crataegi, fructus Lycii, radix astragali, radix Puerariae and Glycyrrhrizae radix respectively, sterilizing, oven drying, slicing, and pulverizing to obtain powder.

B. Mixing the obtained tea leaf and powder with selenium-rich powder.

C. Soaking in 100 deg.C boiled water for 20 min.

Example 2

The brewing tea of the traditional Chinese medicine composition comprises the following components: 3.5g of guava leaves, 0.8g of selenium-rich edible fungus powder, 0.6g of Chinese yam, 0.9g of hawthorn, 0.6g of medlar, 0.9g of astragalus membranaceus, 0.6g of kudzu root, 1g of lotus leaves, 0.7g of mulberry leaves and 0.4g of liquorice. The content of organic selenium in the selenium-rich powder is 300 mug/g.

B. Mixing the obtained tea leaf and powder with selenium-rich powder.

C. Soaking in 100 deg.C boiled water for 20 min.

Example 3

The brewing tea of the traditional Chinese medicine composition comprises the following components: 3.8g of guava leaves, 0.9g of selenium-rich edible fungus powder, 0.5g of Chinese yam, 0.7g of hawthorn, 0.6g of medlar, 0.7g of astragalus membranaceus, 0.6g of kudzu root, 0.9g of lotus leaves, 1g of mulberry leaves and 0.3g of liquorice. The content of organic selenium in the selenium-rich powder is 200 mug/g.

B. Mixing the obtained tea leaf and powder with selenium-rich powder.

C. Soaking in 100 deg.C boiled water for 20 min.

Example 4

The brewing tea of the traditional Chinese medicine composition comprises the following components: 3.3g of guava leaves, 1g of selenium-rich edible fungus powder, 0.7g of Chinese yam, 0.8g of hawthorn, 0.7g of medlar, 0.8g of astragalus membranaceus, 0.7g of kudzu root, 0.7g of lotus leaves, 0.8g of mulberry leaves and 0.5g of liquorice. The content of organic selenium in the selenium-rich powder is 200 mug/g.

B. Mixing the obtained tea leaf and powder with selenium-rich powder.

C. Decocting with slow fire for 15 min.

Example 5

The traditional Chinese medicine composition powder comprises the following components: 3.4g of guava leaves, 0.7g of selenium-rich edible fungus powder, 0.9g of Chinese yam, 0.7g of hawthorn, 0.8g of medlar, 0.7g of astragalus membranaceus, 0.8g of kudzu root, 0.7g of lotus leaves, 0.7g of mulberry leaves and 0.6g of liquorice. The content of organic selenium in the selenium-rich powder is 300 mug/g.

The preparation method of the traditional Chinese medicine composition powder comprises the following steps:

A. cleaning folium Psidii Guajavae, folium Nelumbinis and folium Mori respectively, sterilizing, deactivating enzyme, oven drying, pulverizing into powder, and cleaning rhizoma Dioscoreae, fructus crataegi, fructus Lycii, radix astragali, radix Puerariae and Glycyrrhrizae radix respectively, sterilizing, oven drying, slicing, and pulverizing into powder.

B. Mixing the obtained powder with selenium-rich powder,

C. the mixed powder is used as a raw material, and pharmaceutical auxiliary materials are added to prepare powder.

Example 6

The traditional Chinese medicine composition pill comprises the following components: 3g of guava leaves, 0.6g of selenium-rich edible fungus powder, 0.7g of Chinese yam, 0.9g of hawthorn, 0.7g of medlar, 0.9g of astragalus membranaceus, 0.8g of kudzu root, 0.9g of lotus leaves, 0.9g of mulberry leaves and 0.6g of liquorice. The content of organic selenium in the selenium-rich powder is 400 mug/g.

The preparation method of the traditional Chinese medicine composition pill comprises the following steps:

B. Mixing the obtained powder with selenium-rich powder,

C. adding appropriate amount of wetting agent and binder, and making into pill.

Clinical experiments

All the cases are from outpatients of traditional Chinese medicine, 68 cases of the traditional Chinese medicine syndrome type are caused by dampness-heat of spleen and stomach, the symptoms are mainly caused by stomach heat, the epigastric distending pain, anorexia, bitter taste in mouth, dry mouth, nausea and vomiting, heavy body, drowsiness, yellow urine, red fur, yellow and greasy tongue and slippery pulse, and the inclusion standard is met. In group A, 15 cases of patients with helicobacter pylori positive had been treated with rabeprazole, lizhudele, clarithromycin and amoxicillin clavulanate potassium, and the brewed tea of example 1 was taken at the same time. In group B, 12 patients with helicobacter pylori positive were treated with the infusion tea of example 1. In group C, 41 patients with helicobacter pylori were negative, and only the brewed tea of example 1 was taken. The treatment course is 14 days, Chinese medicine inquiry record analysis is carried out to judge that the drug effect is obvious, effective or ineffective, and pathological examination is carried out to judge whether the helicobacter pylori turns negative or not.

In the group A, 14 helicobacter pylori turns negative (93.3%), 13 patients with remarkable drug effect (86.7%) and 2 patients with significant drug effect (13.3%).

In group B, 9 cases (75%) of helicobacter pylori turned negative, 9 cases (75%) of significant efficacy, 2 cases (16.7%) of efficacy, and 1 case (8.3%) of no efficacy.

Group C had 32 significant effects (78.1%), 7 effective (17.1%), and 2 ineffective (4.8%).

Therefore, the brewed tea has a good curative effect on helicobacter pylori and stomach discomfort, can reduce the damage to the stomach by assisting the four-combined treatment, and improves the healing effect and the healing period (the healing rate of the four-combined treatment for 14 days is about 80 percent generally).

Of the above 68 patients, 22 cases of hypertension, 6 cases of hyperglycemia and 13 cases of hyperlipidemia were observed. The treatment course is 14 days, and the traditional Chinese medicine inquiry and laboratory test blood term record analysis are carried out to judge whether the drug effect is obvious, effective or ineffective.

Hypertension: significantly 9 cases (40.9%), 7 cases (31.8%), and 6 cases (27.3%).

Hyperglycemia: significantly 1 case (16.7%), 3 cases (50%), and 2 cases (33.3%).

Hyperlipidemia: significantly 3 cases (23.1%), 7 cases (53.8%), and 3 cases (23.1%).

Therefore, the brewed tea can relieve the three-high symptoms of the patient.

Typical case 1

Wangzhi, male, 56 years old, 1.85 m in height and 110 kg in weight. Symptoms are: gloomy complexion, drowsiness, lassitude, shortness of breath, lassitude, edema of the lower limbs. Chest oppression, stomach distension and constipation. Positive test of helicobacter pylori. Diabetes mellitus is accompanied by pulmonary heart disease, pericardial effusion and pleural effusion for 14 years. After the brewing tea is taken, the spirit is obviously improved, and the drowsiness and the hypodynamia are obviously improved. After the medicine is taken for 40 days, the test of helicobacter pylori is negative, the body weight is reduced to 90 kg, and the diabetes is improved. After 1 year of administration, the subjective symptoms disappear, the face is ruddy, the heart rhythm is stable, the walking is vigorous, and the bowels are smooth.

Typical case 2

Liza, male, 60 years old, dark and gloomy complexion, dry mouth, loose stool, drowsiness, hypodynamia, gastrectasia, abdominal distention, and positive helicobacter pylori test. After the tea is taken for 30 days, the face is ruddy and glossy, the gastrointestinal function is normal, the spirit is obviously improved, the walking is vigorous, and the helicobacter pylori test is negative.

It should be understood that the above examples are only for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And such obvious variations or modifications which fall within the spirit of the invention are intended to be covered by the scope of the present invention.

Claims

1. The traditional Chinese medicine composition is characterized by comprising the following components in percentage by mass: 25-40% of guava leaves, 5-12% of selenium-rich powder, 4-10% of Chinese yam, 6-10% of hawthorn, 5-9% of wolfberry, 7-9% of astragalus membranaceus, 6-8% of kudzu roots, 7-10% of lotus leaves, 7-10% of mulberry leaves and 3-6% of liquorice.

2. The traditional Chinese medicine composition according to claim 1, wherein: the selenium-rich powder is selenium-rich edible fungus powder, and the content of organic selenium in the selenium-rich powder is 200-400 mug/g.

3. The traditional Chinese medicine composition according to claim 2, wherein: the guava leaf is 30-38% by mass.

4. The traditional Chinese medicine composition according to claim 2, wherein: the selenium-enriched powder accounts for 6-10% by mass.

5. The traditional Chinese medicine composition according to claim 2, wherein: the Chinese yam is 5-9% by mass, the hawthorn is 7-9% by mass, and the wolfberry is 6-8% by mass.

6. The traditional Chinese medicine composition according to any one of claims 1 to 5, wherein: the Chinese medicinal composition can be made into tablet, capsule, oral liquid, buccal agent, granule, potion, pill and powder.

7. The traditional Chinese medicine composition according to any one of claims 1 to 5, wherein: the potion is brewing potion.

8. A method for preparing a drinkable preparation of the Chinese medicinal composition as claimed in claim 1, which comprises: the method comprises the following steps:

B. mixing the prepared tea leaves and powder with selenium-rich powder;

C. soaking with water at 90-100 deg.c for 10-20 min.

9. A method for preparing a drinkable preparation of the Chinese medicinal composition as claimed in claim 1, which comprises: the method comprises the following steps:

B. mixing the prepared tea leaves and powder with selenium-rich powder;

C. decocting the mixture for 10 to 20min by slow fire.

10. A method for preparing the traditional Chinese medicine composition of claim 1, which is characterized by comprising the following steps: the method comprises the following steps:

B. mixing the obtained powder with selenium-rich powder,