CN112439045A

CN112439045A - Medicine for quickly promoting hair growth

Info

Publication number: CN112439045A
Application number: CN201910857244.4A
Authority: CN
Inventors: 王忠民
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-09-04
Filing date: 2019-09-04
Publication date: 2021-03-05

Abstract

The invention discloses a medicine for rapidly promoting hair growth, which is prepared by taking medlar, rhizoma polygonati, mulberry, cistanche, astragalus, Chinese date, peach kernel, safflower, longan pulp, black sesame, fructus cannabis, walnut kernel, angelica, ginger, hawthorn and pepper as raw materials and decocting and extracting the raw materials according to a certain weight ratio. The traditional Chinese medicine can be prepared into any common oral dosage form, has the functions of tonifying kidney and replenishing essence, promoting blood circulation to remove blood stasis, tonifying qi and growing hair and the like, treats alopecia, hair sparseness, premature graying of hair and the like caused by various diseases, and has the advantages of particularly quick response, obvious effect and no toxic or side effect.

Description

Medicine for quickly promoting hair growth

Technical Field

The invention relates to a medicament for rapidly promoting hair growth, in particular to a medicament which is prepared from plant Chinese medicaments which are both edible and medicinal as raw materials and is used for treating various diseases such as alopecia, hair sparseness, premature graying of hair and the like caused by the western medicine treatment process of tumors.

Background

Alopecia is a common disease, and certain adverse effects are brought to the image and the mind of a patient after the alopecia occurs. With the acceleration of the life rhythm of people, adverse effects such as excessive mental stress, insufficient sleep, frequent staying up all night, excessive fatigue, improper diet and the like are common, some people are in a sub-health state, and the incidence rate of alopecia tends to rise year by year and to be younger.

The formation of hair loss is often the result of one or more diseases. The traditional Chinese medicine composition is used for effectively treating alopecia, particularly for safely and effectively treating alopecia through traditional Chinese medicines, and is very important for improving the appearance of a patient, improving the physical and mental health of the patient and eliminating sub-health state. Clinical research data show that alopecia patients often have mild or severe clinical manifestations of low immunity, endocrine dysfunction, skin infection, microcirculation disturbance, anaphylactic reaction, physical decline and the like, so that the application of safe and effective medicaments to cure alopecia is an effective care for physical and mental health of the patients.

However, in the market, the traditional Chinese medicine composition has the advantages of treatment of alopecia, sparse hair and premature graying hair, obvious curative effect, small side effect and few medicines which are convenient to take. Aiming at alopecia with high incidence, a safe and effective therapeutic drug is researched and developed, which is undoubtedly a good news for many patients. According to this situation, the doctor of the traditional Chinese medicine inheritance studio in Tianjin city and the professor of the master physician in Beichen hospital, Wangzhong TCM teacher in Beijing, have conducted extensive and intensive clinical studies on patients with alopecia.

The invention provides a medicine which has reliable curative effect, no toxic or side effect and obvious comprehensive alopecia treatment effect, particularly the medicine developed by using medicine-food dual-purpose traditional Chinese medicines has very important practical significance and is the starting point and the final purpose of the inventor. However, the Chinese patent medicine for treating alopecia is still blank in view of the current medicine market.

Disclosure of Invention

The invention aims to provide a medicament for rapidly promoting hair growth. Modern medical research finds that the pathogenesis of androgenetic alopecia is combined with in-vivo androgen or dihydrotestosterone and receptors on hair follicles on the forehead, so that the hair follicles are miniaturized, the growth period of the hair follicles is shortened, and the hair follicles enter the resting period prematurely to cause alopecia. Meanwhile, baldness is also related to factors such as skin infection, inflammatory reaction, allergy, microcirculation disturbance and the like, and pharmacological research and clinical observation prove that the medicine has the effects of resisting inflammation, inhibiting bacteria, regulating immunity, promoting local blood circulation and estrogen-like action and has a positive effect on promoting hair growth. The Chinese medicine taken orally has the functions of regulating the functions of internal organs, promoting the circulation of qi and blood, promoting the qi and blood circulation in alopecia and skin damage area and benefiting the growth of hair.

According to the traditional Chinese medicine, the alopecia is related to the kidney, the liver, the spleen and qi and blood in the five internal organs. Qi and blood are sufficient and smooth, so the zang-fu organs function normally, and hair is nourished, and the hair is black and black. Kidneys store essence, which generates blood and is glorious; the liver stores blood and regulates and relieves flow of qi, and normal qi and blood can be smoothly cleared; the spleen governs transportation and transformation, and food essence generates qi and blood through the transportation and transformation of the spleen. Therefore, hair growth is normal in functions of kidney, liver, spleen and other organs, and can avoid alopecia, hair thinning, premature graying of hair and the like.

A medicine for promoting hair growth quickly features that the traditional syndrome differentiation and treatment are used as basic rule. The Chinese herbal medicine preparation has the effects of tonifying kidney, nourishing blood, soothing liver, regulating qi, strengthening spleen, tonifying qi, removing blood stasis, dredging meridian passage and achieving the purpose of nourishing hair follicles and growing hair. The Chinese medicine and western medicine are combined, and the used medicines are proved by related pharmacological experiments of modern medicine, have the effects of conditioning viscera qi and blood, enhancing local blood circulation and promoting hair regeneration, and are proved to have the effects and reliability of improving physique, enhancing immune function and promoting physical and mental health.

The invention is realized by the following technical scheme. The medicine for rapidly promoting hair growth is characterized by being prepared from the following raw materials in parts by weight by a conventional preparation method: 10-60 parts of wolfberry fruit, 10-55 parts of rhizoma polygonati, 10-60 parts of mulberry fruit, 10-50 parts of cistanche, 10-60 parts of astragalus membranaceus, 10-45 parts of Chinese date, 10-45 parts of peach kernel, 10-50 parts of safflower, 10-55 parts of arillus longan, 10-50 parts of black sesame, 10-50 parts of fructus cannabis, 10-60 parts of walnut kernel, 10-55 parts of angelica sinensis, 10-50 parts of ginger, 10-50 parts of hawthorn and 10-50 parts of pepper.

The raw material medicaments and the dosage formula are obtained by the inventor through combined clinical tests of many medical institutions for many years, and have obvious curative effect within the dosage range.

The medicine is prepared from wolfberry fruit, rhizoma polygonati, mulberry fruit, cistanche, astragalus, Chinese date, peach kernel, safflower, longan aril, black sesame, fructus cannabis, walnut kernel, angelica, ginger, hawthorn and pepper, and the efficacies of the medicines generate synergistic action, so that the curative effects of tonifying kidney and replenishing essence, promoting blood circulation to remove blood stasis, tonifying qi and growing hair are achieved.

The medlar in the medicine has the effects of nourishing kidney yin, replenishing vital essence and growing hair, and the modern pharmacological research proves that the medlar has particularly remarkable effects of resisting aging, enhancing immunity and the like; rhizoma Polygonati has effects of replenishing kidney essence, invigorating qi and nourishing yin, has good curative effect on alopecia caused by kidney essence deficiency and qi and yin deficiency, and has effects of resisting bacteria, delaying aging, enhancing immunity function, and relieving fatigue; the mulberry has the functions of enriching blood and nourishing yin, nourishing kidney and replenishing essence and growing hair, and has outstanding effects of resisting oxidation, resisting aging, resisting mutagenesis and the like; the cistanche deserticola has the effects of tonifying kidney and strengthening yang, replenishing vital essence and enriching blood, has obvious effect of delaying the aging of hypophysis, gonad, thymus and other parts of a human body, and has certain effect of treating kidney deficiency and alopecia; the astragalus is the essential drug for tonifying qi and spleen, has obvious effect on alopecia caused by deficiency of qi and blood, and has the effects of resisting fatigue, aging, bacteria and viruses, promoting immunologic function and the like; the Chinese date has the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves, is effective in treating alopecia caused by deficiency of qi and blood, and has the effects of resisting oxidation, enhancing immunity, resisting fatigue and the like; the peach kernel has the functions of promoting blood circulation to remove blood stasis, promoting blood circulation and benefiting hair regeneration, and has obvious effects of resisting oxidation, resisting aging, regulating immunity and the like; the safflower has the functions of promoting blood circulation, removing blood stasis, relieving depression, soothing nerves and improving the blood supply of viscera tissues, and has good anti-fatigue and anti-aging effects; the longan pulp has the effects of tonifying heart and spleen, nourishing blood and soothing nerves, can stabilize the anxiety, and has good effects of resisting fatigue, stress, oxidation, bacteria and aging, enhancing immunity and the like; the black sesame has the effects of tonifying kidney and liver, nourishing blood and moistening dryness, blackening and beautifying hair, nourishing yin and detoxifying, promoting granulation and growing hair, is rich in a large amount of vitamin E, contains folic acid, lecithin, protein and the like in addition, has a certain effect on treating alopecia and premature graying of hair, and has the effects of resisting aging, regulating immunity and the like; fructus Cannabis has effects of loosening bowel to relieve constipation, is beneficial to alopecia caused by blood deficiency and body fluid deficiency, and has effects of resisting oxidation, regulating immunity, resisting blood coagulation and resisting thrombosis; the walnut kernel has the effects of benefiting qi and nourishing blood, tonifying kidney and securing essence, blackening hair and strengthening brain, beautifying and benefiting intelligence, resisting oxidation, resisting aging, enhancing immunity and the like; the angelica has the effects of enriching and nourishing blood, promoting blood circulation and moistening dryness, and has the effects of resisting inflammation, eliminating free radicals, regulating immunity, resisting blood coagulation and the like; the ginger has the effects of warming stomach, preventing vomiting, removing dampness and reducing phlegm, and contains volatile oil, so that the ginger can effectively stimulate hair follicles and promote hair regrowth; the hawthorn has the functions of promoting digestion, invigorating stomach, promoting qi circulation, removing blood stasis, strengthening heart, reducing blood pressure, reducing blood fat, preventing tumor, aiding digestion and the like, and has the effects of resisting oxidation, resisting aging and the like; the pricklyash peel contains volatile oil, and the pricklyash peel has the functions of strengthening teeth and hair and mainly growing hair according to records of famous medical records, namely the treatise on the medical treatise.

The formula combination has the functions of tonifying kidney and replenishing essence, activating blood and dissolving stasis, tonifying qi and growing hair and the like, effectively treats alopecia, sparse hair, premature graying hair and the like caused by various diseases, and has the advantages of particularly quick response, obvious effect and no toxic or side effect. The medicines are matched to bring out the best in each other, completely accords with the basic principle of treatment based on syndrome differentiation of traditional Chinese medicine, and also accords with the basic characteristic of combination of disease differentiation and syndrome differentiation.

Moreover, the pharmacological actions of the medicines have related pharmacological research and animal test conclusions.

The medicine can be prepared into oral administration dosage forms by adopting a conventional method of Chinese medicine preparations. The medicine of the invention can be prepared by grinding the raw material medicines into powder and uniformly mixing the powder and the powder into powder, granules and oral liquid. The raw materials can be decocted in water and then concentrated into decoction to obtain effective components, and then the effective components are prepared into various oral preparations, but the invention is not limited by the protection scope of the invention.

The medicine can also be used for extracting effective components by adopting methods such as semi-bionic extraction (SBE), Supercritical Fluid Extraction (SFE), microwave extraction (MAE), enzyme extraction (ETE), ultrasonic extraction (UAE), semi-bionic extraction (SEB), squeezing extraction (PE), Continuous Countercurrent Extraction (CCE), tissue disruption extraction (STE), heating-free extraction (HFE), normal-temperature ultrahigh-pressure extraction (U HPE), Air Explosion Extraction (AEE) and the like, and the extraction methods are all in the protection range of the medicine.

The following capsule formulations are preferred for use in the present invention.

The preparation method of the medicine comprises the following steps:

(1) weighing the raw materials in proportion for later use;

(2) checking and accepting 16 Chinese medicinal materials of medlar, rhizoma polygonati, mulberry, cistanche, astragalus, Chinese date, peach kernel, safflower, longan aril, black sesame, fructus cannabis, walnut kernel, angelica, ginger, hawthorn and pepper in the weight ratio, and delivering the qualified Chinese medicinal materials to a professional Chinese medicinal pharmacy factory for extraction;

(3) extracting by a pharmaceutical factory according to a conventional method and a conventional program for extracting traditional Chinese medicines;

(4) packaging the extracted medicinal powder into bottled capsules, wherein each bottle contains 60 capsules, and each capsule contains 0.45g of the Chinese medicinal extract powder;

(5) the finished product is delivered to clinical trials by the pharmaceutical factory.

The clinical use results show that the medicine of the invention has the following advantages:

1. the invention selects natural edible plant medicines as raw materials, and each component accords with the regulation of a pharmaceutical law and the principle of a traditional Chinese medicine prescription, and highlights the basic characteristics of the combination of traditional Chinese medicine syndrome differentiation and western medicine disease differentiation and the combination of etiology treatment and symptomatic treatment;

2. the medicine of the invention does not need to be decocted, has good taste and convenient taking, is nontoxic and harmless before and after the prescription of each medicine, and has no side effect after being taken with normal dose;

3. the medicine has good treatment effect on alopecia, sparse hair and premature graying hair, has good prevention and health care effects, and has wide application range;

4. the medicine is selected from varieties which can be used as both medicine and food and are regulated by Ministry of health, has higher safety, and can be taken by patients with alopecia, sparse hair or premature graying hair for a long time;

5. the medicine has good compatibility, and has certain compatibility treatment effect on the symptoms such as constipation, insomnia, consumptive disease, hypodynamia and the like which are easy to appear in middle-aged and elderly people;

6. the medicine has good effects of tonifying kidney, strengthening spleen, soothing liver and the like, has good regulation effect on the sub-health state of middle-aged and elderly people, and can obviously relieve various disease symptoms caused by the regulation effect;

7. the medicine of the invention treats both principal and secondary aspect of disease, and has quick effect.

Detailed Description

The effect of the present invention will be further illustrated by the following examples and clinical application statistics.

Example 1: capsule preparation

24kg of medlar, 18kg of rhizoma polygonati, 22kg of mulberry, 15kg of cistanche, 18kg of astragalus, 10kg of Chinese date, 12kg of peach kernel, 10kg of safflower, 8kg of longan pulp, 12kg of black sesame, 12kg of fructus cannabis, 10kg of walnut kernel, 12kg of angelica, 12kg of ginger, 15kg of hawthorn and 6kg of pepper are subjected to ingredient preparation, extracted and processed by a Chinese medicine preparation factory, and prepared into Chinese medicine capsules, wherein each capsule is 0.45 g.

Example 2: tablet preparation

24kg of medlar, 18kg of rhizoma polygonati, 22kg of mulberry, 15kg of cistanche, 18kg of astragalus, 10kg of Chinese date, 12kg of peach kernel, 10kg of safflower, 8kg of longan pulp, 12kg of black sesame, 12kg of fructus cannabis, 10kg of walnut kernel, 12kg of angelica, 12kg of ginger, 15kg of hawthorn and 6kg of pepper are subjected to ingredient preparation by a traditional Chinese medicine pharmaceutical factory, extraction and processing are carried out, and traditional Chinese medicine tablets are prepared, wherein each tablet is 0.5 g.

Clinical observation of the drug of the invention

General conditions

In order to verify the clinical treatment effect of the medicine, 152 seborrheic alopecia patients are observed in the outpatient clinic of traditional Chinese medicine in a Hospital hospital from 3 months to 5 months in 2013, the patients are 19 to 50 years old, and the patients are divided into an observation group and a control group according to a digital random table method. 76 groups were observed, 65 men and 11 women; age 19-50 years, mean age (30.3 ± 12.9) years: the course of disease is 5 months to 11 years, and the average course of disease (1.2 +/-0.56) years. Control group 76, 66 men and 10 women; the age is 19-50 years, the mean age (30.5 + -12.7) years; the course of disease is 6 months to 11.5 years, and the average course of disease (1.2 +/-0.55) years. The general data of two groups, such as sex, age, course, etc., have no significant difference after statistical treatment and are comparable (P > 0.05).

Diagnostic criteria: the secretion of oil is vigorous, the hair is greasy, or the dandruff is obvious and accompanied by pruritus, and the hair is dry; the hair is in diffuse slow-falling state, or the hair is obviously sparse.

And (3) inclusion standard: according with the diagnosis of the disease, the patients with age of 19-50 years are actively matched with treatment and successfully finish the prescribed course of treatment, glucocorticoid or immunosuppressant is not used before the treatment, and traditional Chinese medicines or androgen-inhibiting medicines are not taken within 1 week.

Exclusion criteria: endocrine alopecia such as hypothyroidism or hyperthyroidism, hypoparathyroidism or hypophysis, hypogonadism, diabetes, etc., drug-induced alopecia, symptomatic alopecia, postpartum alopecia, and postpartum alopecia in lactation or gestational women, which do not meet the selection criteria or do not have complete data to influence the judgment of curative effect.

Second, test method

Comparison medication: the observation group takes a medicine for rapidly promoting hair growth, capsule (produced by Jiangsu Yihai pharmaceutical company, Limited liability company), 0.45g per capsule, 3 times per day, 4 capsules per capsule; the control group orally administered cystamine acid tablet (Shanxi Linfen Yunpeng pharmaceutical Co., Ltd.) 50mg each time, 3 times daily, and vitamin B6 tablet (Shenyang first pharmaceutical Co., Ltd., northeast pharmaceutical Co., Ltd.) 10mg each time, 3 times daily. Both groups should be taken continuously for 3 months, and should be stopped taking and related drugs should be taken externally during the treatment period, and pungent foods should not be eaten, and light diet should be paid attention.

The curative effect standard is as follows: hair loss is stopped, no greasy feeling, no itching, no desquamation, no dryness, more than 80% of skin lesions grow new hair or vellus hairs are healed; new hair growth occurs at 60% of skin lesions, the greasy feeling and the fatty desquamation are obviously reduced, and the pruritus is obviously relieved; new hair grows at 30% of skin lesions, the greasy feeling and the fatty desquamation are partially reduced, and the itching degree is partially relieved; no new hair growth, no reduction of greasy feeling and greasy desquamation, and no relief of pruritus.

And (3) statistical treatment: statistical analysis is carried out by adopting SPSS15.0 statistical software, and Chi is adopted for comparing the curative effects of the two groups²The test shows that P is less than 0.05, which shows that the difference is statistical.

And (3) analyzing the curative effect: 54 cases (71.1%) of observation groups in 76 cases are cured, 17 cases (22.4%) of significant effect, 3 cases (3.9%) of effective effect, 2 cases (2.6%) of ineffective effect and 97.4% of total effective rate are obtained; in 76 control groups, 26 cases (34.2) are cured, 19 cases (25.0) with obvious effect, 13 cases (17.1) with effect, 18 cases (23.7) with no effect and 76.3 percent of total effective rate are obtained. Clinical observation results show that the effect of the medicine for rapidly promoting hair growth on treating alopecia is obviously superior to that of a control group particularly in the aspect of recovery rate, the total effective rate has statistical difference (P is less than 0.05), and the medicine has certain popularization value.

Claims

1. The formula of the medicine is characterized in that the medicine is a medicine and food dual-purpose traditional Chinese medicine formula and is prepared from the following raw material medicines in parts by weight:

2. the medicine for rapidly promoting hair growth according to claim 1, wherein the formula is characterized in that the capsule is prepared by adopting a conventional process of Chinese materia medica pharmaceutics.

3. The medicine for rapidly promoting hair growth according to claim 1, wherein the formula is characterized in that the medicine is prepared into tablets by adopting a conventional process of Chinese materia medica pharmaceutics.

4. The medicine for rapidly promoting hair growth according to claim 1, wherein the formula is characterized in that the medicine is prepared into powder or granules by adopting a conventional process of Chinese materia medica pharmaceutics.

5. The medicament for rapidly promoting hair growth according to claim 1, wherein the medicament is prepared into water pills, honey pills, water honey pills, concentrated pills or dripping pills by a conventional process of Chinese materia medica pharmaceutics.

6. The medicine for rapidly promoting hair growth according to claim 1, wherein the formula is characterized in that the oral liquid is prepared by adopting a conventional process of Chinese materia medica pharmaceutics.

7. The medicine for rapidly promoting hair growth according to claim 1, wherein the formula is characterized in that the medicine is prepared into tea by adopting a conventional process of Chinese materia medica pharmaceutics.