CN112426391A - Chitosan nourishing and skin moistening shower gel and preparation method thereof - Google Patents

Abstract

The invention relates to a chitosan nourishing skin-moistening shower gel and a preparation method thereof, wherein the chitosan nourishing skin-moistening shower gel comprises, by weight, 3.5-45.0 parts of a surfactant, 0.01-2.0 parts of a cherry blossom extract, 0.5-4.0 parts of a chitosan solution, 0.01-0.3 part of a chelating agent, 0.012-2.0 parts of a pH regulator, 0.6-8.0 parts of a thickening agent, 0.02-0.3 part of a preservative and 60-90 parts of deionized water. The addition of multiple surfactants with optimized proportion has good compatibility, strong cleaning capability, mild performance of improving the thickening property and the foamability of the shower gel, fine and stable foam, easy cleaning and no residue; meanwhile, the added sodium chloride can further change the viscosity of the surfactant and improve the surface activity of the surfactant. The interaction of the added oriental cherry extract and the chitosan solution can reduce the stimulation of the bath foam to the skin, provide certain protection and repair effects, and obviously improve the problems of skin allergy, skin dryness and the like caused by using preservatives, sodium laureth sulfate and other surfactants.

Description

Chitosan nourishing and skin moistening shower gel and preparation method thereof

Technical Field

The invention relates to the technical field of daily chemicals, and particularly relates to chitosan nourishing and skin moistening shower gel and a preparation method thereof.

Background

The shower gel is a necessary product for cleaning skin dirt during bathing. Compared with the soap, the bath cream has the advantages of mild property, abundant foam and more convenient use because the pH of the bath cream is close to that of human skin, so that the bath cream becomes a preferred product for cleaning the whole body skin of a consumer. However, the current shower gel is generally formed by mixing chemicals, and particularly, certain specific surfactants and preservatives have irritation or side effects on the skin. When the shower gel is used for cleaning excessive dirt and grease of the skin, the natural grease and other natural conditioning and moisturizing components of the skin can be removed, various skin problems such as dry skin, desquamation, itching and the like can be caused, and the problems are particularly serious when a large amount of components such as a surfactant, a foaming agent, a soap base and the like with extremely strong alkalinity are used in the shower gel.

With the continuous improvement of living standard, the demand and the requirement of people on body bath articles are higher and higher, which also puts forward higher and higher requirements for formula engineers in the technical field: rich foam, good cleaning ability, high mildness and refreshing skin feel after bathing. The skin feel after bathing is not fresh enough, and although the cleansing ability is strong, the skin sebum mucous membrane can be damaged after long-term use, and the skin sensitivity is easily caused. Meanwhile, preservatives and other skin conditioners which are also inevitably added into the shower gel can cause the allergy phenomenon of partial people. The long-term use of the health-care tea causes great hidden danger to health.

Disclosure of Invention

Aiming at the technical problems that the shower gel in the prior art is easy to cause allergy, dry and itchy skin and the like, the invention provides the chitosan nourishing and moisturizing shower gel and the preparation method thereof.

In order to realize the purpose, the invention is realized by the following technical scheme:

the first purpose of the invention is to provide a chitosan nourishing and skin moistening shower gel, which comprises the following components in parts by weight

(1)3.50-45.0 parts of surfactant;

(2)0.01-2.0 parts of oriental cherry extract;

(3)0.5-4.0 parts of chitosan solution;

(4)0.01-0.3 parts of chelating agent;

(5)0.012-2.0 parts of pH regulator;

(6)0.6-8.0 parts of thickening agent;

(7)0.02-0.3 parts of preservative; and

(8)60-90 parts of deionized water;

the surfactant comprises 1-15 parts of sodium laureth sulfate, 1-15 parts of cocamidopropyl betaine, 1-10 parts of sodium lauroamphoacetate and 0.5-5 parts of lauryl glucoside;

the thickening agent comprises 0.5-5.0 parts of acrylate copolymer and 0.1-3.0 parts of sodium chloride;

the preparation method of the chitosan solution comprises the following steps: dissolving 100mg hyaluronic acid powder and 50mg chitosan powder in 80ml acetic acid water solution with concentration of 1 wt%, oscillating at room temperature for 1h, and filtering with filter membrane to obtain chitosan solution.

Further, the chelating agent is disodium EDTA.

Further, the shower gel also comprises 0.01-2.0 parts of panthenol by weight.

Further, the preservative is a mixture of magnesium chloride, methyl chloro isothiazolinone, methyl isothiazolinone and magnesium nitrate, and the molar ratio of the methyl chloro isothiazolinone to the methyl isothiazolinone is 3: 1.

still further, the preservative also comprises 0.01-0.2 part of DMDM hydantoin in parts by weight.

Further, the shower gel further comprises 0.1-2 parts of a cleaning agent in parts by weight, wherein the cleaning agent is a mixture of ethylene glycol distearate, C8-C14 alkyl glucoside and betaine, and the molar ratio of the ethylene glycol distearate, the C8-C14 alkyl glucoside and the betaine is 1: 1: 0.1.

further, the shower gel also comprises 0.01-1 part of aromatic in parts by weight.

Further, the pH regulator comprises 0.01-1.0 part of citric acid and 0.002-1.0 part of sodium hydroxide.

The second purpose of the invention is to provide a preparation method of the chitosan nourishing and skin moistening shower gel, which comprises the following steps:

(1) weighing deionized water, sodium laureth sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, lauryl glucoside and a chelating agent, sequentially adding into a stirring pot, stirring and dispersing uniformly, heating, homogenizing until the raw materials are dissolved, controlling the temperature to be 80-85 ℃, and cooling after all the raw materials are completely dissolved;

(2) when the temperature in the stirring pot is reduced to 45 ℃, adding the acrylate copolymer into the stirring pot, and stirring for 15-20 minutes;

(3) adding sodium hydroxide, cherry blossom extract and chitosan solution into a stirring pot, and rapidly and uniformly stirring when adding; stirring for 10 minutes, sequentially adding sodium chloride, preservative and pH regulator, stirring uniformly, sampling, inspecting, filtering after qualified, and discharging.

Further, the method comprises the following steps:

(1) weighing deionized water, sodium laureth sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, lauryl glucoside, panthenol and a chelating agent, sequentially adding into a stirring pot, stirring and dispersing uniformly, heating, homogenizing until the raw materials are dissolved, controlling the temperature to be 80-85 ℃, and cooling after all the raw materials are completely dissolved;

(2) when the temperature in the stirring pot is reduced to 45 ℃, adding the acrylate copolymer into the stirring pot, and stirring for 15-20 minutes;

(3) sequentially adding sodium hydroxide, cherry blossom extract and chitosan solution into a stirring pot, and rapidly and uniformly stirring when adding; after stirring for 10 minutes, the mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone and magnesium nitrate, the cleaning agent, sodium chloride, DMDM hydantoin and citric acid are added in sequence and stirred uniformly, sampling is carried out, inspection is carried out, and filtering and discharging are carried out after the materials are qualified.

Compared with the prior art, the invention has the following beneficial technical effects:

experiments prove that the interaction of the cherry blossom extract and the chitosan solution added in the invention can reduce the stimulation of the bath foam to the skin, provide certain protection and repair effects, and obviously improve the problems of skin allergy, skin dryness and the like caused by using preservatives, sodium laureth sulfate and other surfactants.

According to the invention, the sodium laureth sulfate, the cocamidopropyl betaine, the sodium lauroamphoacetate and the lauryl glucoside are added according to an optimized proportion, so that various surfactants have good compatibility and strong cleaning capability, the thickening property and the foaming property of the shower gel are improved, the shower gel is mild, the foam is fine and stable, the shower gel is easy to clean and does not remain; meanwhile, the added sodium chloride can further change the viscosity of the surfactant and improve the surface activity of the surfactant.

The cherry blossom extract added with the optimized proportion has the effects of inhibiting the activity of tyrosinase, whitening skin and resisting inflammation to a certain extent. The panthenol added in the optimized proportion has the functions of moisturizing the skin and resisting inflammation.

Detailed Description

The following examples are presented to illustrate certain embodiments of the invention in particular and should not be construed as limiting the scope of the invention. The present disclosure may be modified from materials, methods, and reaction conditions at the same time, and all such modifications are intended to be within the spirit and scope of the present invention. Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art. The reagents and biomaterials, if not specifically indicated, are commercially available.

The preparation method of the chitosan solution comprises the following steps: dissolving 100mg hyaluronic acid powder and 50mg chitosan powder in 80ml acetic acid water solution with concentration of 1 wt%, oscillating at room temperature for 1h, and filtering with filter membrane to obtain chitosan solution.

The mixture of the preservatives magnesium chloride, methyl chloro isothiazolinone, methyl isothiazolinone and magnesium nitrate for cosmetics is prepared according to GB/T29666-2013.

Cherry extract: a fine brown yellow powder of cherry blossom extract is purchased from a Murray organism and dissolved in a mixed solvent of water, butylene glycol and phenoxyethanol. The mol ratio of oriental cherry extract powder, water, butanediol and phenoxyethanol is 1: 30: 10: 10.

example 1:

a chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 1 part of sodium laureth sulfate, 1 part of cocamidopropyl betaine, 1 part of sodium lauroamphoacetate, 1.5 parts of lauryl glucoside, 0.01 part of oriental cherry extract, 0.5 part of chitosan solution, 0.2 part of disodium EDTA, 0.01 part of citric acid, 0.002 part of sodium hydroxide, 2.5 parts of acrylate copolymer, 0.1 part of sodium chloride, 0.02 part of preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, magnesium nitrate), 60 parts of deionized water.

The preparation method of the shower gel comprises the following steps:

(1) weighing deionized water, sodium laureth sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, lauryl glucoside and a chelating agent, sequentially adding into a stirring pot, stirring and dispersing uniformly, heating, homogenizing until the raw materials are dissolved, controlling the temperature to be 80-85 ℃, and cooling after all the raw materials are completely dissolved;

(2) when the temperature in the stirring pot is reduced to 45 ℃, adding the acrylate copolymer into the stirring pot, and stirring for 15-20 minutes;

(3) adding sodium hydroxide, cherry blossom extract and chitosan solution into a stirring pot, and rapidly and uniformly stirring when adding; stirring for 10 min, sequentially adding sodium chloride, antiseptic (mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, and magnesium nitrate), and citric acid, stirring, sampling, inspecting, filtering, and discharging.

Example 2:

a chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 15 parts of sodium laureth sulfate, 5 parts of cocamidopropyl betaine, 10 parts of sodium lauroamphoacetate, 0.5 part of lauryl glucoside, 2.0 parts of oriental cherry extract, 0.01 part of panthenol, 4.0 parts of chitosan solution, 0.01 part of disodium EDTA, 0.5 part of citric acid, 1.0 part of sodium hydroxide, 0.5 part of an acrylate copolymer, 1.5 parts of sodium chloride, 0.3 part of a preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, magnesium nitrate), 0.01 part of DMDM hydantoin, and 75 parts of deionized water.

The preparation method of the shower gel comprises the following steps:

(1) weighing deionized water, sodium laureth sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, lauryl glucoside, panthenol and a chelating agent, sequentially adding into a stirring pot, stirring and dispersing uniformly, heating, homogenizing until the raw materials are dissolved, controlling the temperature to be 80-85 ℃, and cooling after all the raw materials are completely dissolved;

(2) when the temperature in the stirring pot is reduced to 45 ℃, adding the acrylate copolymer into the stirring pot, and stirring for 15-20 minutes;

(3) adding sodium hydroxide, cherry blossom extract and chitosan solution into a stirring pot, and rapidly and uniformly stirring when adding; stirring for 10 min, sequentially adding sodium chloride, antiseptic (mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, and magnesium nitrate), antiseptic DMDM hydantoin, and citric acid, stirring, sampling, inspecting, filtering, and discharging.

Example 3:

a chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 10 parts of sodium laureth sulfate, 15 parts of cocamidopropyl betaine, 6 parts of sodium lauroamphoacetate, 5.0 parts of lauryl glucoside, 1.0 part of oriental cherry extract, 2.0 parts of panthenol, 2.0 parts of chitosan solution, 0.3 parts of disodium EDTA, 1.0 part of citric acid, 0.5 part of sodium hydroxide, 5.0 parts of an acrylate copolymer, 3.0 parts of sodium chloride, 0.15 part of a preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, magnesium nitrate), 0.2 part of DMDM hydantoin, and 90 parts of deionized water.

The preparation method is the same as example 2.

Example 4:

a chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 10 parts of sodium laureth sulfate, 15 parts of cocamidopropyl betaine, 6 parts of sodium lauroamphoacetate, 5.0 parts of lauryl glucoside, 1.0 part of oriental cherry extract, 2.0 parts of panthenol, 2.0 parts of chitosan solution, 0.3 parts of disodium EDTA, 1.0 part of citric acid, 0.5 part of sodium hydroxide, 5.0 parts of an acrylate copolymer, 3.0 parts of sodium chloride, 0.15 part of a preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, magnesium nitrate), 0.2 part of DMDM hydantoin, 0.1 part of a detergent (being ethylene glycol distearate, C8-C14 alkyl glucoside, a mixture of betaines, ethylene glycol distearate, C8-C14 alkyl glucoside, the molar ratio of betaines being 1: 1: 0.1) and 90 parts of deionized water.

The preparation method of the shower gel comprises the following steps:

(1) weighing deionized water, sodium laureth sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, lauryl glucoside, panthenol and a chelating agent, sequentially adding into a stirring pot, stirring and dispersing uniformly, heating, homogenizing until the raw materials are dissolved, controlling the temperature to be 80-85 ℃, and cooling after all the raw materials are completely dissolved;

(2) when the temperature in the stirring pot is reduced to 45 ℃, adding the acrylate copolymer into the stirring pot, and stirring for 15-20 minutes;

(3) adding sodium hydroxide, cherry blossom extract and chitosan solution into a stirring pot, and rapidly and uniformly stirring when adding; stirring for 10 min, sequentially adding detergent, sodium chloride, antiseptic (mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, and magnesium nitrate), antiseptic DMDM hydantoin, and citric acid, stirring, sampling, inspecting, filtering, and discharging.

Example 5:

a chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 15 parts of sodium laureth sulfate, 5 parts of cocamidopropyl betaine, 10 parts of sodium lauroamphoacetate, 0.5 part of lauryl glucoside, 2.0 parts of oriental cherry extract, 1.0 part of panthenol, 4.0 parts of chitosan solution, 0.01 part of disodium EDTA, 0.5 part of citric acid, 1.0 part of sodium hydroxide, 0.5 part of an acrylate copolymer, 1.5 parts of sodium chloride, 0.3 part of a preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, magnesium nitrate), 0.01 part of DMDM hydantoin, 2.0 parts of a detergent (being ethylene glycol distearate, C8-C14 alkyl glucoside, a mixture of betaines, ethylene glycol distearate, C8-C14 alkyl glucoside, the molar ratio of betaines being 1: 1: 0.1), 0.01 part of a perfume, 0.5 part of CI 16255 and 75 parts of deionized water.

The preparation method of the shower gel comprises the following steps:

(1) weighing deionized water, sodium laureth sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, lauryl glucoside, panthenol and a chelating agent, sequentially adding into a stirring pot, stirring and dispersing uniformly, heating, homogenizing until the raw materials are dissolved, controlling the temperature to be 80-85 ℃, and cooling after all the raw materials are completely dissolved;

(2) when the temperature in the stirring pot is reduced to 45 ℃, adding the acrylate copolymer into the stirring pot, and stirring for 15-20 minutes;

(3) adding sodium hydroxide, cherry blossom extract and chitosan solution into a stirring pot, and rapidly and uniformly stirring when adding; stirring for 10 min, sequentially adding detergent, sodium chloride, antiseptic (mixture of magnesium chloride, methyl chloroisothiazolinone, methyl isothiazolinone, and magnesium nitrate), antiseptic DMDM hydantoin, citric acid, essence, and CI 16255, stirring, sampling, inspecting, filtering, and discharging.

Example 6:

a chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 15 parts of sodium laureth sulfate, 5 parts of cocamidopropyl betaine, 10 parts of sodium lauroamphoacetate, 0.5 part of lauryl glucoside, 2.0 parts of oriental cherry extract, 1.0 part of panthenol, 4.0 parts of chitosan solution, 0.01 part of disodium EDTA, 0.5 part of citric acid, 1.0 part of sodium hydroxide, 0.5 part of an acrylate copolymer, 1.5 parts of sodium chloride, 0.3 part of a preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, magnesium nitrate), 0.01 part of DMDM hydantoin, 1.0 part of a detergent (being ethylene glycol distearate, C8-C14 alkyl glucoside, a mixture of betaines, ethylene glycol distearate, C8-C14 alkyl glucoside, the molar ratio of betaines being 1: 1: 0.1), 1.0 part of a perfume, 0.0001 parts of CI 16255 and 75 parts of deionized water.

The preparation method is the same as example 5.

Comparative example 1: compared with example 1, without addition of oriental cherry extract

A chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 1 part of sodium laureth sulfate, 1 part of cocamidopropyl betaine, 1 part of sodium lauroamphoacetate, 1.5 parts of lauryl glucoside, 0.5 part of chitosan solution, 0.2 part of disodium EDTA, 0.01 part of citric acid, 0.002 part of sodium hydroxide, 2.5 parts of acrylate copolymer, 0.1 part of sodium chloride, 0.02 part of preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone and magnesium nitrate), 60 parts of deionized water.

The preparation method is the same as example 1.

Comparative example 2: compared with example 1, no chitosan solution was added

A chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 1 part of sodium laureth sulfate, 1 part of cocamidopropyl betaine, 1 part of sodium lauroamphoacetate, 1.5 parts of lauryl glucoside, 0.01 part of oriental cherry extract, 0.2 part of disodium EDTA, 0.01 part of citric acid, 0.002 part of sodium hydroxide, 2.5 parts of acrylate copolymer, 0.1 part of sodium chloride, 0.02 part of preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, magnesium nitrate), 60 parts of deionized water.

The preparation method is the same as example 1.

Comparative example 3: compared with the embodiment 1, the sodium chloride is not added, and sodium laureth sulfate is not used as the main surfactant

A chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 1 part of cocamidopropyl betaine, 1 part of sodium lauroamphoacetate, 1.5 parts of lauryl glucoside, 0.01 part of oriental cherry extract, 0.5 part of chitosan solution, 0.2 part of disodium EDTA, 0.01 part of citric acid, 0.002 part of sodium hydroxide, 2.5 parts of acrylate copolymer, 0.02 part of preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone and magnesium nitrate), and 60 parts of deionized water.

The preparation method is the same as example 1.

Comparative example 4: in comparison with example 1, no cocamidopropyl betaine was added

A chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 1 part of sodium laureth sulfate, 1 part of sodium lauroamphoacetate, 1.5 parts of lauryl glucoside, 0.01 part of oriental cherry extract, 0.5 part of chitosan solution, 0.2 part of disodium EDTA, 0.01 part of citric acid, 0.002 part of sodium hydroxide, 2.5 parts of acrylate copolymer, 0.1 part of sodium chloride, 0.02 part of preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone, magnesium nitrate), 60 parts of deionized water.

The preparation method is the same as example 1.

Comparative example 5: compared with example 2, without adding panthenol and oriental cherry extract

A chitosan nourishing and skin moistening shower gel comprises the following components in parts by weight: 15 parts of sodium laureth sulfate, 5 parts of cocamidopropyl betaine, 10 parts of sodium lauroamphoacetate, 0.5 part of lauryl glucoside, 4.0 parts of chitosan solution, 0.01 part of disodium EDTA, 0.5 part of citric acid, 1.0 part of sodium hydroxide, 0.5 part of acrylate copolymer, 1.5 parts of sodium chloride, 0.3 part of preservative (a mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone and magnesium nitrate), 0.01 part of DMDM and 75 parts of deionized water.

The preparation method is the same as example 2.

Experimental example 1: the performance of the shower gels of examples 1 to 6 and comparative examples 3 to 4 was measured.

1. Foam performance

Reference GB/T13173-91, using Ross-Miles method determination. 10g of the samples of examples 1 to 6 and comparative examples 3 to 4 were weighed out and used at 150 mg/kg^-1Dissolving the hard water, fixing the volume to a volumetric flask of 1000mL, and placing the prepared solution in a constant-temperature water bath at 40 ℃ for 0.5 h. After 200mL of sample liquid has been poured at 40 ℃ from a height of 90cm onto the surface of 50mL of the same sample liquid at the bottom of the graduated cylinder, the liquid is collided to generate foam, and immediately a stopwatch is started and the corresponding foam height of the system is recorded at 30s and 5 min. Foaming capacity was characterized by a foam height (H0) corresponding to 30s, and stability of the foam was characterized by a ratio (H5/H0) of the corresponding foam height (H5) to (H0) after 5min of equilibrium.

The above experiment was repeated to obtain results with an error of within 5% between the results of at least 3 trials.

2. Usage sensing test

According to the using performances of mildness, moistening type, cleaning property, itching relieving and the like of the shower gel, 160 (20 in each group) volunteers are used for evaluating the effect, the scoring standard is 10 points, the higher the score is, the better the effect is, and the average value of the statistical result is taken.

3. The result of the detection

The results of measuring the foaming properties and the effects of use of the bath gels of examples 1 to 6 and comparative examples 2 to 5 are shown in Table 2.

TABLE 1 foaming Properties and results of use of the shower gels of examples 1 to 6 and comparative examples 2 to 5

The results show that: (1) the sodium laureth sulfate, the cocamidopropyl betaine, the sodium lauroamphoacetate and the lauryl glucoside in optimized proportion are added, and various surfactants have good compatibility and strong cleaning capability, improve the thickening property and the foamability of the shower gel, have mild performance, fine and stable foam, are easy to clean and do not remain; meanwhile, the added sodium chloride can further change the viscosity of the surfactant and improve the surface activity of the surfactant. (2) The cherry blossom extract added with the optimized proportion has the effects of inhibiting the activity of tyrosinase, whitening skin and resisting inflammation to a certain extent. The panthenol added in the optimized proportion has the functions of moisturizing the skin and resisting inflammation. (3) The chitosan solution with the optimized proportion is added to improve the skin moisturizing effect.

Experimental example 2: the performances of the bath lotions of examples 1 to 6 and comparative examples 1 to 2 were measured

1. Influence on dextran-induced skin itch model of mouse

SPF-grade KM mice, half male and half female, weighing 18-22 g. The groups were randomized into 8 groups of 10 individuals. The back of the mouse is unhaired, and the medicine is applied to the back of the mouse according to the weight of the mouse, wherein the medicine is 0.1ml/g, and is administered for 2 times/day for 7 days. 30min after the last administration, dextran (mw 40000) injected into tail vein of each group of mice at 1.25mg/kg (0.025%, 0.05ml/10g) resulted in an animal model of paroxysmal skin itch. The head of the mouse is grabbed by the front paw, the trunk of the mouse is scratched by the back paw, and all parts of the whole body are bitten by the mouth to serve as pruritus indications. The number of itching episodic episodes of the mice within 30min was recorded.

TABLE 2 skin itch test in each group of mice

2. Crowd trial test of shower gel

The population selection standard is as follows: sensitive people who have allergic phenomena such as dry skin, pruritus, red swelling, pimple and the like when using other types of shower gel.

According to the above population inclusion criteria, 400 subjects were selected. 200 male and 200 female; the age is 18-50 years, and the average is 8 groups, each group containing 50 people.

The sample using method comprises the following steps:

the shower gel samples prepared in examples 1 to 6 were used for bathing 1 time a day, and the data were counted after one week. The test results are shown in table 3.

Table 3 test results on the trial of the population of the shower gel

	Example 1	Example 2	Example 3	Example 4	Example 5	Example 6	Comparative example 1	Comparative example 2
									The number of allergic people	1	1	0	0	0	0	49	50

Experiments prove that the interaction of the cherry blossom extract and the chitosan solution added in the invention can reduce the stimulation of the bath foam to the skin, provide certain protection and repair effects, and obviously improve the problems of skin allergy, skin dryness and the like caused by using preservatives, sodium laureth sulfate and other surfactants.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (10)

1. The chitosan nourishing and skin moistening shower gel is characterized by comprising the following components in parts by weight

(1)3.50-45.0 parts of surfactant;

(2)0.01-2.0 parts of oriental cherry extract;

(3)0.5-4.0 parts of chitosan solution;

(4)0.01-0.3 parts of chelating agent;

(5)0.012-2.0 parts of pH regulator;

(6)0.6-8.0 parts of thickening agent;

(7)0.02-0.3 parts of preservative; and

(8)60-90 parts of deionized water;

the surfactant comprises 1-15 parts of sodium laureth sulfate, 1-15 parts of cocamidopropyl betaine, 1-10 parts of sodium lauroamphoacetate and 0.5-5 parts of lauryl glucoside;

the thickening agent comprises 0.5-5.0 parts of acrylate copolymer and 0.1-3.0 parts of sodium chloride;

the preparation method of the chitosan solution comprises the following steps: dissolving 100mg hyaluronic acid powder and 50mg chitosan powder in 80ml acetic acid water solution with concentration of 1 wt%, oscillating at room temperature for 1h, and filtering with filter membrane to obtain chitosan solution.

2. The chitosan nourishing and skin moistening shower gel as claimed in claim 1, wherein the chelating agent is disodium EDTA.

3. The chitosan nourishing and moisturizing body wash as claimed in claim 1, further comprising 0.01-2.0 parts by weight of panthenol.

4. The chitosan nourishing and skin moistening shower gel as claimed in claim 1, wherein the preservative is a mixture of magnesium chloride, methyl chloro isothiazolinone, methyl isothiazolinone and magnesium nitrate, and the molar ratio of the methyl chloro isothiazolinone to the methyl isothiazolinone is 3: 1.

5. the chitosan nourishing and moisturizing body wash as claimed in claim 4, wherein the preservative further comprises 0.01-0.2 parts by weight of DMDM hydantoin.

6. The chitosan nourishing and skin moistening shower gel as claimed in claim 1, further comprising 0.1-2 parts by weight of a cleanser, wherein the cleanser is a mixture of ethylene glycol distearate, C8-C14 alkyl glucoside and betaine, and the molar ratio of the ethylene glycol distearate, the C8-C14 alkyl glucoside and the betaine is 1: 1: 0.1.

7. the chitosan nourishing and moisturizing body wash as claimed in claim 1, further comprising 0.01-1 part of a fragrance by weight.

8. The chitosan nourishing and moisturizing body wash as claimed in claim 1, wherein the pH regulator comprises 0.01-1.0 part of citric acid and 0.002-1.0 part of sodium hydroxide.

9. The preparation method of the chitosan nourishing and skin-moistening body wash as claimed in claims 1-8, which is characterized by comprising the following steps:

(1) weighing deionized water, sodium laureth sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, lauryl glucoside and a chelating agent, sequentially adding into a stirring pot, stirring and dispersing uniformly, heating, homogenizing until the raw materials are dissolved, controlling the temperature to be 80-85 ℃, and cooling after all the raw materials are completely dissolved;

(2) when the temperature in the stirring pot is reduced to 45 ℃, adding the acrylate copolymer into the stirring pot, and stirring for 15-20 minutes;

(3) adding sodium hydroxide, cherry blossom extract and chitosan solution into a stirring pot, and rapidly and uniformly stirring when adding; stirring for 10 minutes, sequentially adding sodium chloride, preservative and pH regulator, stirring uniformly, sampling, inspecting, filtering after qualified, and discharging.

10. The preparation method of the chitosan nourishing and skin moistening shower gel as claimed in claim 9, which is characterized by comprising the following steps:

(1) weighing deionized water, sodium laureth sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, lauryl glucoside, panthenol and a chelating agent, sequentially adding into a stirring pot, stirring and dispersing uniformly, heating, homogenizing until the raw materials are dissolved, controlling the temperature to be 80-85 ℃, and cooling after all the raw materials are completely dissolved;

(2) when the temperature in the stirring pot is reduced to 45 ℃, adding the acrylate copolymer into the stirring pot, and stirring for 15-20 minutes;

(3) sequentially adding sodium hydroxide, cherry blossom extract and chitosan solution into a stirring pot, and rapidly and uniformly stirring when adding; after stirring for 10 minutes, the mixture of magnesium chloride, methylchloroisothiazolinone, methylisothiazolinone and magnesium nitrate, the cleaning agent, sodium chloride, DMDM hydantoin and citric acid are added in sequence and stirred uniformly, sampling is carried out, inspection is carried out, and filtering and discharging are carried out after the materials are qualified.