CN112399852A - 固体和液体恶性肿瘤中多重抗原受体t细胞对多种抗原的靶向 - Google Patents

固体和液体恶性肿瘤中多重抗原受体t细胞对多种抗原的靶向 Download PDF

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CN112399852A
CN112399852A CN201980043041.XA CN201980043041A CN112399852A CN 112399852 A CN112399852 A CN 112399852A CN 201980043041 A CN201980043041 A CN 201980043041A CN 112399852 A CN112399852 A CN 112399852A
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tumor
antigen
cancer
cells
associated antigen
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C·诺维纳
R·J·迪斯特尔
A·诺比利
S·C·奈尔
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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CN201980043041.XA 2018-06-28 2019-06-27 固体和液体恶性肿瘤中多重抗原受体t细胞对多种抗原的靶向 Pending CN112399852A (zh)

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US201862691486P 2018-06-28 2018-06-28
US62/691,486 2018-06-28
US201862697526P 2018-07-13 2018-07-13
US62/697,526 2018-07-13
PCT/US2019/039620 WO2020006312A1 (en) 2018-06-28 2019-06-27 Targeting of multiple antigens with multiplex car t cells in solid and liquid malignancies

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AU (1) AU2019291882A1 (enExample)
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Families Citing this family (7)

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WO2021076197A1 (en) 2019-10-15 2021-04-22 Diverse Biotech, Inc. Conjugate molecules
US20220354815A1 (en) * 2019-11-19 2022-11-10 Oklahoma Medical Research Foundation Okn-007 as a therapeutic agent
KR20230104594A (ko) * 2020-11-05 2023-07-10 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 자극-반응성 어댑터를 통한 범용 car t 세포의 조건부 제어
AU2021397206A1 (en) * 2020-12-08 2023-07-27 Seattle Children's Hospital (dba Seattle Children's Research Institute) Anti-egfr chimeric antigen receptors
US11883499B2 (en) 2022-02-01 2024-01-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
US11660348B1 (en) 2022-02-01 2023-05-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
WO2025085511A1 (en) * 2023-10-18 2025-04-24 University Of Washington Systems and methods for polymer-mediated activation of engineered cells

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110288275A1 (en) * 2001-02-12 2011-11-24 Research Development Foundation Modified Proteins, Designer Toxins, and Methods of Making Thereof
CN102341504A (zh) * 2009-03-10 2012-02-01 索尼公司 细胞分离方法
WO2015168656A2 (en) * 2014-05-02 2015-11-05 Adheren Incorporated Biological complexes and methods for using same
CN105814083A (zh) * 2013-10-15 2016-07-27 加州生物医学研究所 嵌合抗原受体t细胞开关和其用途
WO2017143094A1 (en) * 2016-02-16 2017-08-24 Dana-Farber Cancer Institute, Inc. Immunotherapy compositions and methods
CN110545847A (zh) * 2017-04-25 2019-12-06 达纳-法伯癌症研究所有限公司 用于肿瘤的靶向免疫疗法的组合物和方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ603581A (en) 2010-06-19 2015-05-29 Sloan Kettering Inst Cancer Anti-gd2 antibodies
EP3693017A1 (en) 2010-12-14 2020-08-12 University of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer
PE20150998A1 (es) 2012-10-02 2015-06-29 Epitherapeutics Aps Inhibidores de histona demetilasas
ES2949648T3 (es) 2012-12-20 2023-10-02 Purdue Research Foundation Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer
PL3597742T3 (pl) 2014-10-09 2022-11-14 Yamaguchi University Wektor ekspresyjny CAR oraz komórki T wykazujące ekspresję CAR
WO2016154621A1 (en) 2015-03-26 2016-09-29 The California Institute For Biomedical Research SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF
AU2016248946C1 (en) * 2015-04-13 2024-10-17 Pfizer Inc. Therapeutic antibodies and their uses
WO2016168769A1 (en) * 2015-04-15 2016-10-20 The California Institute For Biomedical Research Chimeric receptor t cell switches for her2
WO2017112877A1 (en) 2015-12-22 2017-06-29 Icell Gene Therapeutics, Llc Chimeric antigen receptors and enhancement of anti-tumor activity
CN105504042A (zh) 2016-02-04 2016-04-20 北京艺妙神州医疗科技有限公司 检测car-t细胞的捕获探针、该细胞含量的检测方法及应用
US20170274095A1 (en) 2016-03-23 2017-09-28 The Board Of Trustees Of The Leland Stanford Junior University Enhanced regulatory t cells targeted to sites of inflammation with chimeric antigen receptors and expressing factors that enhance viability of pancreatic cells
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Car t細胞療法のための方法および組成物
US11174306B2 (en) 2016-10-19 2021-11-16 The Scripps Research Institute Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof
CA3053534A1 (en) 2017-02-17 2018-08-23 Purdue Research Foundation Targeted ligand-payload based drug delivery for cell therapy
US11850262B2 (en) 2017-02-28 2023-12-26 Purdue Research Foundation Compositions and methods for CAR T cell therapy
CN108490174B (zh) 2018-04-18 2022-06-24 上海尚珞生物医药科技有限公司 检测car-t细胞的方法及其应用
CN108660113A (zh) 2018-05-21 2018-10-16 杭州启澜生物医学技术有限公司 一种制备改良型car-t细胞的方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110288275A1 (en) * 2001-02-12 2011-11-24 Research Development Foundation Modified Proteins, Designer Toxins, and Methods of Making Thereof
CN102341504A (zh) * 2009-03-10 2012-02-01 索尼公司 细胞分离方法
CN105814083A (zh) * 2013-10-15 2016-07-27 加州生物医学研究所 嵌合抗原受体t细胞开关和其用途
WO2015168656A2 (en) * 2014-05-02 2015-11-05 Adheren Incorporated Biological complexes and methods for using same
WO2017143094A1 (en) * 2016-02-16 2017-08-24 Dana-Farber Cancer Institute, Inc. Immunotherapy compositions and methods
CN110545847A (zh) * 2017-04-25 2019-12-06 达纳-法伯癌症研究所有限公司 用于肿瘤的靶向免疫疗法的组合物和方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘威: "乏氧响应型抗肿瘤诊疗前药的设计、合成及评价", 中国优秀硕士学位论文全文数据库(电子期刊), no. 01, 15 January 2018 (2018-01-15), pages 3 *

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