JP2021530444A - 固形および液体悪性病変における多重car t細胞での複数抗原の標的化 - Google Patents
固形および液体悪性病変における多重car t細胞での複数抗原の標的化 Download PDFInfo
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- JP2021530444A JP2021530444A JP2020571522A JP2020571522A JP2021530444A JP 2021530444 A JP2021530444 A JP 2021530444A JP 2020571522 A JP2020571522 A JP 2020571522A JP 2020571522 A JP2020571522 A JP 2020571522A JP 2021530444 A JP2021530444 A JP 2021530444A
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025015837A JP2025072462A (ja) | 2018-06-28 | 2025-02-03 | 固形および液体悪性病変における多重car t細胞での複数抗原の標的化 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862691486P | 2018-06-28 | 2018-06-28 | |
| US62/691,486 | 2018-06-28 | ||
| US201862697526P | 2018-07-13 | 2018-07-13 | |
| US62/697,526 | 2018-07-13 | ||
| PCT/US2019/039620 WO2020006312A1 (en) | 2018-06-28 | 2019-06-27 | Targeting of multiple antigens with multiplex car t cells in solid and liquid malignancies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015837A Division JP2025072462A (ja) | 2018-06-28 | 2025-02-03 | 固形および液体悪性病変における多重car t細胞での複数抗原の標的化 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021530444A true JP2021530444A (ja) | 2021-11-11 |
| JPWO2020006312A5 JPWO2020006312A5 (enExample) | 2022-07-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020571522A Pending JP2021530444A (ja) | 2018-06-28 | 2019-06-27 | 固形および液体悪性病変における多重car t細胞での複数抗原の標的化 |
| JP2025015837A Pending JP2025072462A (ja) | 2018-06-28 | 2025-02-03 | 固形および液体悪性病変における多重car t細胞での複数抗原の標的化 |
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| EP4240772A4 (en) * | 2020-11-05 | 2025-02-26 | University of Pittsburgh - of the Commonwealth System of Higher Education | CONDITIONAL CONTROL OF UNIVERSAL CAR-T CELLS BY STIMULUS-RESPONSE ADAPTERS |
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| WO2025085511A1 (en) * | 2023-10-18 | 2025-04-24 | University Of Washington | Systems and methods for polymer-mediated activation of engineered cells |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010207133A (ja) * | 2009-03-10 | 2010-09-24 | Sony Corp | 細胞分離方法 |
| WO2016168769A1 (en) * | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Chimeric receptor t cell switches for her2 |
| JP2016534995A (ja) * | 2013-10-15 | 2016-11-10 | ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ | キメラ抗原受容体t細胞スイッチおよびその使用 |
| WO2017143094A1 (en) * | 2016-02-16 | 2017-08-24 | Dana-Farber Cancer Institute, Inc. | Immunotherapy compositions and methods |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200305980B (en) | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
| NZ603581A (en) | 2010-06-19 | 2015-05-29 | Sloan Kettering Inst Cancer | Anti-gd2 antibodies |
| EP3693017A1 (en) | 2010-12-14 | 2020-08-12 | University of Maryland, Baltimore | Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer |
| HRP20170358T1 (hr) | 2012-10-02 | 2017-04-21 | Gilead Sciences, Inc. | Inhibitori histonskih demetilaza |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| US10744207B2 (en) | 2014-05-02 | 2020-08-18 | Acepodia, Inc. | Biological complexes and methods for using same |
| SG11201702391RA (en) | 2014-10-09 | 2017-04-27 | Univ Yamaguchi | Car expression vector and car-expressing t cells |
| WO2016154621A1 (en) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
| TWI703159B (zh) * | 2015-04-13 | 2020-09-01 | 美商輝瑞股份有限公司 | Bcma特異性治療性抗體及其用途 |
| US20180371052A1 (en) | 2015-12-22 | 2018-12-27 | Icell Gene Therapeutics Llc | Chimeric antigen receptors and enhancement of anti-tumor activity |
| CN105504042A (zh) | 2016-02-04 | 2016-04-20 | 北京艺妙神州医疗科技有限公司 | 检测car-t细胞的捕获探针、该细胞含量的检测方法及应用 |
| US20170274095A1 (en) | 2016-03-23 | 2017-09-28 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced regulatory t cells targeted to sites of inflammation with chimeric antigen receptors and expressing factors that enhance viability of pancreatic cells |
| CA3019835A1 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| AU2017345479B2 (en) * | 2016-10-19 | 2024-03-21 | The Scripps Research Institute | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
| ES3024357T3 (en) | 2017-02-17 | 2025-06-04 | Purdue Research Foundation | Targeted ligand-payload based drug delivery for cell therapy |
| US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
| CN110545847A (zh) * | 2017-04-25 | 2019-12-06 | 达纳-法伯癌症研究所有限公司 | 用于肿瘤的靶向免疫疗法的组合物和方法 |
| CN108490174B (zh) | 2018-04-18 | 2022-06-24 | 上海尚珞生物医药科技有限公司 | 检测car-t细胞的方法及其应用 |
| CN108660113A (zh) | 2018-05-21 | 2018-10-16 | 杭州启澜生物医学技术有限公司 | 一种制备改良型car-t细胞的方法 |
-
2019
- 2019-06-27 CN CN201980043041.XA patent/CN112399852A/zh active Pending
- 2019-06-27 AU AU2019291882A patent/AU2019291882A1/en not_active Abandoned
- 2019-06-27 JP JP2020571522A patent/JP2021530444A/ja active Pending
- 2019-06-27 WO PCT/US2019/039620 patent/WO2020006312A1/en not_active Ceased
- 2019-06-27 EP EP19825236.3A patent/EP3813863A4/en active Pending
- 2019-06-27 US US17/254,472 patent/US12466869B2/en active Active
-
2025
- 2025-02-03 JP JP2025015837A patent/JP2025072462A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010207133A (ja) * | 2009-03-10 | 2010-09-24 | Sony Corp | 細胞分離方法 |
| JP2016534995A (ja) * | 2013-10-15 | 2016-11-10 | ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ | キメラ抗原受容体t細胞スイッチおよびその使用 |
| WO2016168769A1 (en) * | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Chimeric receptor t cell switches for her2 |
| WO2017143094A1 (en) * | 2016-02-16 | 2017-08-24 | Dana-Farber Cancer Institute, Inc. | Immunotherapy compositions and methods |
Non-Patent Citations (2)
| Title |
|---|
| CLANTON, J. A. ET AL.: ""Lineage labeling of zebrafish cells with laser uncagable fluorescein dextran"", J. VIS. EXP., vol. 50, JPN6024040313, 2011, pages 1 - 3, ISSN: 0005429828 * |
| LI, X. ET AL.: ""Cancer-Associated, Stimuli-Driven, Turn on Theranostics for Multimodality Imaging and Therapy"", ADV. MATER., vol. Vol. 29; 1606857, JPN6023019642, 2017, pages 1 - 24, ISSN: 0005245933 * |
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| US20210137987A1 (en) | 2021-05-13 |
| US12466869B2 (en) | 2025-11-11 |
| JP2025072462A (ja) | 2025-05-09 |
| EP3813863A4 (en) | 2022-07-06 |
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