AU2019291882A1 - Targeting of multiple antigens with multiplex CAR T cells in solid and liquid malignancies - Google Patents

Targeting of multiple antigens with multiplex CAR T cells in solid and liquid malignancies Download PDF

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Publication number
AU2019291882A1
AU2019291882A1 AU2019291882A AU2019291882A AU2019291882A1 AU 2019291882 A1 AU2019291882 A1 AU 2019291882A1 AU 2019291882 A AU2019291882 A AU 2019291882A AU 2019291882 A AU2019291882 A AU 2019291882A AU 2019291882 A1 AU2019291882 A1 AU 2019291882A1
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AU
Australia
Prior art keywords
tumor associated
associated antigen
antigen
cells
targeting
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Abandoned
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AU2019291882A
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English (en)
Inventor
Robert J. Distel
Steven C. NEIER
Alberto Nobili
Carl NOVINA
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication of AU2019291882A1 publication Critical patent/AU2019291882A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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AU2019291882A 2018-06-28 2019-06-27 Targeting of multiple antigens with multiplex CAR T cells in solid and liquid malignancies Abandoned AU2019291882A1 (en)

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US201862691486P 2018-06-28 2018-06-28
US62/691,486 2018-06-28
US201862697526P 2018-07-13 2018-07-13
US62/697,526 2018-07-13
PCT/US2019/039620 WO2020006312A1 (en) 2018-06-28 2019-06-27 Targeting of multiple antigens with multiplex car t cells in solid and liquid malignancies

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US20230414754A1 (en) * 2020-11-05 2023-12-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Conditional control of universal car t cells through stimulus-reactive adaptors
AU2021397206A1 (en) * 2020-12-08 2023-07-27 Seattle Children's Hospital (dba Seattle Children's Research Institute) Anti-egfr chimeric antigen receptors
US11883499B2 (en) 2022-02-01 2024-01-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
US11660348B1 (en) 2022-02-01 2023-05-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
WO2025085511A1 (en) * 2023-10-18 2025-04-24 University Of Washington Systems and methods for polymer-mediated activation of engineered cells

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