CN112384627A - 通过利用内源激活诱导性胞嘧啶脱氨酶改造b淋巴细胞 - Google Patents

通过利用内源激活诱导性胞嘧啶脱氨酶改造b淋巴细胞 Download PDF

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CN112384627A
CN112384627A CN201980046344.7A CN201980046344A CN112384627A CN 112384627 A CN112384627 A CN 112384627A CN 201980046344 A CN201980046344 A CN 201980046344A CN 112384627 A CN112384627 A CN 112384627A
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lymphocytes
peptide
antibody
poly
lymphocyte
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A·兰扎韦基亚
K·德拉洛萨
P·帕帕罗迪斯
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Institute for Research in Biomedicine IRB
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/33—Antibodies; T-cell engagers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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CN201980046344.7A 2018-05-30 2019-05-29 通过利用内源激活诱导性胞嘧啶脱氨酶改造b淋巴细胞 Pending CN112384627A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2018/064299 2018-05-30
EP2018064299 2018-05-30
PCT/EP2019/064109 WO2019229193A1 (en) 2018-05-30 2019-05-29 Engineering b lymphocytes by utilizing endogenous activation-induced cytidine deaminase

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CN112384627A true CN112384627A (zh) 2021-02-19

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US (1) US20210254106A1 (https=)
EP (1) EP3802841A1 (https=)
JP (2) JP2021525517A (https=)
KR (1) KR20210016446A (https=)
CN (1) CN112384627A (https=)
AU (1) AU2019276261A1 (https=)
BR (1) BR112020024354A2 (https=)
CA (1) CA3100112A1 (https=)
EA (1) EA202092807A1 (https=)
MX (1) MX2020012895A (https=)
SG (1) SG11202011280SA (https=)
WO (1) WO2019229193A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN117063890A (zh) * 2023-07-11 2023-11-17 吉林大学 一种heca基因不表达的异种移植供体猪及制备方法

Families Citing this family (4)

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CN114181901B (zh) * 2021-12-08 2024-02-02 杭州中赢生物医疗科技有限公司 一种免疫细胞的体外诱导扩增和冻存的方法
EP4522736A2 (en) * 2022-05-10 2025-03-19 Editas Medicine, Inc. Genome editing of b cells
EP4698226A2 (en) * 2023-04-17 2026-02-25 Be Biopharma, Inc. Engineered cell preparations for treatment of hemophilia
WO2025147573A2 (en) * 2024-01-05 2025-07-10 Immusoft Corporation Glp-1 expressing modified b cells for the treatment of metabolic disease

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US20160289637A1 (en) * 2015-04-03 2016-10-06 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
CN108138201A (zh) * 2015-09-04 2018-06-08 托卡根公司 包含2a肽的重组载体

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FR2726003B1 (fr) 1994-10-21 2002-10-18 Agronomique Inst Nat Rech Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires
ATE271122T1 (de) 1996-11-12 2004-07-15 Pfizer Attenuierter lebender neospora impfstoff
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Publication number Priority date Publication date Assignee Title
CN117063890A (zh) * 2023-07-11 2023-11-17 吉林大学 一种heca基因不表达的异种移植供体猪及制备方法

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JP2021525517A (ja) 2021-09-27
WO2019229193A1 (en) 2019-12-05
EA202092807A1 (ru) 2021-04-08
MX2020012895A (es) 2021-05-27
KR20210016446A (ko) 2021-02-15
CA3100112A1 (en) 2019-12-05
SG11202011280SA (en) 2020-12-30
AU2019276261A1 (en) 2020-12-03
EP3802841A1 (en) 2021-04-14
US20210254106A1 (en) 2021-08-19
BR112020024354A2 (pt) 2021-03-02
JP2024063211A (ja) 2024-05-10

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