MX2020012895A - Modificacion de linfocitos b al utilizar citidina desaminasa inducida por activacion endogena. - Google Patents

Modificacion de linfocitos b al utilizar citidina desaminasa inducida por activacion endogena.

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Publication number
MX2020012895A
MX2020012895A MX2020012895A MX2020012895A MX2020012895A MX 2020012895 A MX2020012895 A MX 2020012895A MX 2020012895 A MX2020012895 A MX 2020012895A MX 2020012895 A MX2020012895 A MX 2020012895A MX 2020012895 A MX2020012895 A MX 2020012895A
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MX
Mexico
Prior art keywords
lymphocytes
engineering
cytidine deaminase
induced cytidine
engineered
Prior art date
Application number
MX2020012895A
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English (en)
Inventor
Antonio Lanzavecchia
La Rosa Kathrin De
Philipp Paparoditis
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Inst Res Biomedicine
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Publication date
Application filed by Inst Res Biomedicine filed Critical Inst Res Biomedicine
Publication of MX2020012895A publication Critical patent/MX2020012895A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12Y305/04005—Cytidine deaminase (3.5.4.5)
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Abstract

La presente invención proporciona un método para modificar linfocitos B al utilizar citidina desaminasa inducida por activación del linfocito B. De esta manera, el uso de las nucleasas modificadas, tal como Cas nucleasa, se puede evitar. Las células B modificadas son útiles para producir anticuerpos personalizados y para terapia de células B. Por consiguiente, la presente invención también proporciona células B modificadas y anticuerpos personalizados producidos por las células B modificadas.
MX2020012895A 2018-05-30 2019-05-29 Modificacion de linfocitos b al utilizar citidina desaminasa inducida por activacion endogena. MX2020012895A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2018064299 2018-05-30
PCT/EP2019/064109 WO2019229193A1 (en) 2018-05-30 2019-05-29 Engineering b lymphocytes by utilizing endogenous activation-induced cytidine deaminase

Publications (1)

Publication Number Publication Date
MX2020012895A true MX2020012895A (es) 2021-05-27

Family

ID=62620827

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012895A MX2020012895A (es) 2018-05-30 2019-05-29 Modificacion de linfocitos b al utilizar citidina desaminasa inducida por activacion endogena.

Country Status (12)

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US (1) US20210254106A1 (es)
EP (1) EP3802841A1 (es)
JP (1) JP2021525517A (es)
KR (1) KR20210016446A (es)
CN (1) CN112384627A (es)
AU (1) AU2019276261A1 (es)
BR (1) BR112020024354A2 (es)
CA (1) CA3100112A1 (es)
EA (1) EA202092807A1 (es)
MX (1) MX2020012895A (es)
SG (1) SG11202011280SA (es)
WO (1) WO2019229193A1 (es)

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Publication number Priority date Publication date Assignee Title
CN114181901B (zh) * 2021-12-08 2024-02-02 杭州中赢生物医疗科技有限公司 一种免疫细胞的体外诱导扩增和冻存的方法
WO2023220206A2 (en) * 2022-05-10 2023-11-16 Editas Medicine, Inc. Genome editing of b cells

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340740A (en) 1992-05-15 1994-08-23 North Carolina State University Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process
FR2726003B1 (fr) 1994-10-21 2002-10-18 Agronomique Inst Nat Rech Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires
DE69729839T2 (de) 1996-11-12 2005-07-21 Pfizer Inc. Attenuierter lebender Neospora Impfstoff
FR2836924B1 (fr) 2002-03-08 2005-01-14 Vivalis Lignees de cellules aviaires utiles pour la production de substances d'interet
PL1646715T3 (pl) 2003-07-22 2010-10-29 Valneva Wytwarzanie pokswirusów za pomocą linii adherentnych lub nieadherentnych komórek ptasich
US8326547B2 (en) 2009-10-07 2012-12-04 Nanjingjinsirui Science & Technology Biology Corp. Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm
WO2012063048A1 (en) * 2010-11-08 2012-05-18 Kymab Limited Cells & vertebrates for enhanced somatic hypermutation and class switch recombination
EP2927227A4 (en) 2013-01-03 2015-12-30 Celltrion Inc ANTIBODY CONCENTRATOR REMEDY CONJUGATE, METHOD OF MANUFACTURING THEREOF, AND ANTIBODY TOGETHER THEREWITH
ES2959608T3 (es) 2015-04-03 2024-02-27 Dana Farber Cancer Inst Inc Composición y métodos de edición del genoma de células B
US20180179274A1 (en) 2015-06-26 2018-06-28 Institute For Research In Biomedicine Proteins comprising a mutated lair-1 fragment and uses thereof
EA201890640A1 (ru) * 2015-09-04 2018-09-28 Токаджен Инк. Рекомбинантные векторы, содержащие пептид 2а
WO2019024979A1 (en) 2017-07-31 2019-02-07 Institute For Research In Biomedicine FUNCTIONAL DOMAIN ANTIBODIES IN THE ELBOW REGION

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Publication number Publication date
AU2019276261A1 (en) 2020-12-03
SG11202011280SA (en) 2020-12-30
EP3802841A1 (en) 2021-04-14
JP2021525517A (ja) 2021-09-27
CN112384627A (zh) 2021-02-19
BR112020024354A2 (pt) 2021-03-02
EA202092807A1 (ru) 2021-04-08
CA3100112A1 (en) 2019-12-05
WO2019229193A1 (en) 2019-12-05
KR20210016446A (ko) 2021-02-15
US20210254106A1 (en) 2021-08-19

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