CN112375621A - Preparation method and application of atractylis lancea volatile oil - Google Patents

Preparation method and application of atractylis lancea volatile oil Download PDF

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Publication number
CN112375621A
CN112375621A CN202011499483.6A CN202011499483A CN112375621A CN 112375621 A CN112375621 A CN 112375621A CN 202011499483 A CN202011499483 A CN 202011499483A CN 112375621 A CN112375621 A CN 112375621A
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China
Prior art keywords
extracting
volatile oil
preparation
residue
powder
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Withdrawn
Application number
CN202011499483.6A
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Chinese (zh)
Inventor
苏刘花
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Nanjing Zelang Medical Technology Co Ltd
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Nanjing Zelang Medical Technology Co Ltd
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Priority to CN202011499483.6A priority Critical patent/CN112375621A/en
Publication of CN112375621A publication Critical patent/CN112375621A/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C11B1/104—Production of fats or fatty oils from raw materials by extracting using super critical gases or vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/12—Production of fats or fatty oils from raw materials by melting out
    • C11B1/16—Production of fats or fatty oils from raw materials by melting out with steam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a preparation method and application of atractylis lancea volatile oil. The preparation method comprises the following steps: crushing rhizoma Atractylodis into powder, adding appropriate amount of water, and extracting by steam distillation to obtain distillate and residue. Extracting the residue for 2 times, concentrating the filtrate, adding into supercritical extraction kettle, and performing supercritical CO extraction with ethanol as entrainer2Extracting, and extracting the extract with diethyl ether to obtain Atractylodes lancea volatile oil. The atractylis lancea volatile oil has certain antibacterial activity on various bacteria, and can be applied to the fields of daily chemicals, medicines and the like.

Description

Preparation method and application of atractylis lancea volatile oil
Technical Field
The invention relates to a preparation method and application of atractylis lancea volatile oil.
Background
The volatile oil is an active component with therapeutic effect, and is a general term for volatile components extracted from Chinese medicinal materials. The chemical components are complex, most of the components have aromatic odor, and the medical effect on various aspects is clinically achieved. By consulting the literature, the main pharmacological actions of the volatile oil traditional Chinese medicines are as follows: (1) has effects in relieving pain, tranquilizing mind, relieving fever, and relieving inflammation; (2) effects on the cardiovascular system; (3) effects on the respiratory system; (4) acting on the digestive system; (5) antibacterial and antiviral effects; (6) has antitumor effect.
Atractylodes lancea (Thunb.) DC. is a perennial herb of Atractylodes of Compositae. The dried rhizome of the rhizoma atractylodis is the main source of the traditional Chinese medicine rhizoma atractylodis, has the efficacies of eliminating dampness, strengthening spleen, dispelling wind, improving eyesight and the like, and is a genuine medicinal material in Jiangsu province. In recent years, the promotion effect of microbial factors, especially endophytes, on the accumulation of active ingredients of medicinal materials is proved by a great deal of research. The study on atractylis lancea at the early stage of the subject group shows that the inoculation of the atractylis lancea endophytic fungus Convolvula Gilmaiella sp.AL12 can effectively promote the accumulation increase of the four main components of beta-eucalyptol, atractylone, atractyl alcohol and the like and atractyloin the atractylis aseptic seedling. Therefore, the company develops research on the preparation method and the application of the rhizoma atractylodis volatile oil.
Disclosure of Invention
The invention aims to provide a preparation method and application of atractylis lancea volatile oil, and the volatile oil has an obvious antibacterial effect.
The invention is completed by the following technical scheme:
crushing Atractylodes lancea rhizome into powder, adding appropriate amount of water into 1kg of powder, and extracting by steam distillation to obtain distillate and residue. Extracting the residue for 2 times, concentrating the filtrate, adding into supercritical extraction kettle, and performing supercritical CO extraction with ethanol as entrainer at 5 vol% of the total extraction solvent2Extracting under 20-40MPa and 40-50 deg.C CO2Extracting at flow rate of 20-40L/h for 2-3h, collecting extract, extracting with diethyl ether for 2 times, drying the extractive solution with anhydrous sodium sulfate, and concentrating under reduced pressure to obtain Atractylodes lancea volatile oil.
The atractylis lancea volatile oil prepared by the invention has certain antibacterial activity on various bacteria, and can be applied to the fields of daily chemicals, medicines and the like.
The present invention will be further described with reference to specific embodiments, but the scope of the invention as claimed is not limited to the following embodiments.
The specific implementation mode is as follows:
example 1:
crushing Atractylodes lancea rhizome into powder, adding appropriate amount of water into 1kg of powder, and distilling with steamExtracting to obtain distillate and residue. Extracting the residue for 2 times, concentrating the filtrate, adding into supercritical extraction kettle, and performing supercritical CO extraction with ethanol as entrainer at 5 vol% of the total extraction solvent2Extracting under 20MPa and 40 deg.C with CO2Extracting at flow rate of 20L/h for 2h, collecting extract, extracting with diethyl ether for 2 times, drying the extractive solution with anhydrous sodium sulfate, and concentrating under reduced pressure to obtain Atractylodes lancea volatile oil.
Example 2:
crushing Atractylodes lancea rhizome into powder, adding appropriate amount of water into 1kg of powder, and extracting by steam distillation to obtain distillate and residue. Extracting the residue for 2 times, concentrating the filtrate, adding into supercritical extraction kettle, and performing supercritical CO extraction with ethanol as entrainer at 5 vol% of the total extraction solvent2Extracting under 30MPa at 45 deg.C with CO2Extracting at flow rate of 30L/h for 3h, collecting extract, extracting with diethyl ether for 2 times, drying the extractive solution with anhydrous sodium sulfate, and concentrating under reduced pressure to obtain Atractylodes lancea volatile oil.
Example 3:
crushing Atractylodes lancea rhizome into powder, adding appropriate amount of water into 1kg of powder, and extracting by steam distillation to obtain distillate and residue. Extracting the residue for 2 times, concentrating the filtrate, adding into supercritical extraction kettle, and performing supercritical CO extraction with ethanol as entrainer at 5 vol% of the total extraction solvent2Extracting under 40MPa at 50 deg.C with CO2Extracting at flow rate of 40L/h for 2h, collecting extract, extracting with diethyl ether for 2 times, drying the extractive solution with anhydrous sodium sulfate, and concentrating under reduced pressure to obtain Atractylodes lancea volatile oil.

Claims (2)

1. A preparation method and application of atractylis lancea volatile oil are characterized by comprising the following steps: crushing Atractylodes lancea rhizome into powder, adding appropriate amount of water into 1kg of powder, and steamingDistilling to obtain distillate and residue. Extracting the residue for 2 times, concentrating the filtrate, adding into supercritical extraction kettle, and performing supercritical CO extraction with ethanol as entrainer at 5 vol% of the total extraction solvent2Extracting under 20-40MPa and 40-50 deg.C CO2Extracting at flow rate of 20-40L/h for 2-3h, collecting extract, extracting with diethyl ether for 2 times, drying the extractive solution with anhydrous sodium sulfate, and concentrating under reduced pressure to obtain Atractylodes lancea volatile oil.
2. The use of the atractylis lancea volatile oil prepared according to the method of claim 1 in the preparation of daily chemical and pharmaceutical drugs with antibacterial and bactericidal effects.
CN202011499483.6A 2020-12-18 2020-12-18 Preparation method and application of atractylis lancea volatile oil Withdrawn CN112375621A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011499483.6A CN112375621A (en) 2020-12-18 2020-12-18 Preparation method and application of atractylis lancea volatile oil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011499483.6A CN112375621A (en) 2020-12-18 2020-12-18 Preparation method and application of atractylis lancea volatile oil

Publications (1)

Publication Number Publication Date
CN112375621A true CN112375621A (en) 2021-02-19

Family

ID=74590822

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202011499483.6A Withdrawn CN112375621A (en) 2020-12-18 2020-12-18 Preparation method and application of atractylis lancea volatile oil

Country Status (1)

Country Link
CN (1) CN112375621A (en)

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WW01 Invention patent application withdrawn after publication
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Application publication date: 20210219