CN100465183C - Method of comprehensive utilizing schisandra fruit - Google Patents
Method of comprehensive utilizing schisandra fruit Download PDFInfo
- Publication number
- CN100465183C CN100465183C CNB2006100415664A CN200610041566A CN100465183C CN 100465183 C CN100465183 C CN 100465183C CN B2006100415664 A CNB2006100415664 A CN B2006100415664A CN 200610041566 A CN200610041566 A CN 200610041566A CN 100465183 C CN100465183 C CN 100465183C
- Authority
- CN
- China
- Prior art keywords
- extraction
- shizandra berry
- extract
- lignanoid
- schisandra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 35
- 235000008422 Schisandra chinensis Nutrition 0.000 title claims abstract description 29
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 17
- 240000006079 Schisandra chinensis Species 0.000 title description 10
- 238000000605 extraction Methods 0.000 claims abstract description 46
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000000284 extract Substances 0.000 claims abstract description 34
- 150000004676 glycans Chemical class 0.000 claims abstract description 34
- 239000005017 polysaccharide Substances 0.000 claims abstract description 34
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 34
- 239000000843 powder Substances 0.000 claims abstract description 20
- 241000736075 Schisandra Species 0.000 claims abstract description 19
- 229930013686 lignan Natural products 0.000 claims abstract description 12
- 150000005692 lignans Chemical class 0.000 claims abstract description 12
- 235000009408 lignans Nutrition 0.000 claims abstract description 12
- 239000012530 fluid Substances 0.000 claims abstract description 6
- 238000003809 water extraction Methods 0.000 claims abstract description 5
- 235000021028 berry Nutrition 0.000 claims description 51
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
- 229960004756 ethanol Drugs 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 238000001556 precipitation Methods 0.000 claims description 7
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 230000007935 neutral effect Effects 0.000 claims description 4
- 230000003068 static effect Effects 0.000 claims description 4
- 238000000967 suction filtration Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 241001506371 Kadsura Species 0.000 description 8
- UFCGDBKFOKKVAC-DSASHONVSA-N Schisantherin A Chemical compound O([C@H]1C=2C=C(C(=C(OC)C=2C2=C(OC)C=3OCOC=3C=C2C[C@H](C)[C@@]1(O)C)OC)OC)C(=O)C1=CC=CC=C1 UFCGDBKFOKKVAC-DSASHONVSA-N 0.000 description 5
- HLVXFWDLRHCZEI-UHFFFAOYSA-N chromotropic acid Chemical compound OS(=O)(=O)C1=CC(O)=C2C(O)=CC(S(O)(=O)=O)=CC2=C1 HLVXFWDLRHCZEI-UHFFFAOYSA-N 0.000 description 5
- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 5
- 239000013558 reference substance Substances 0.000 description 5
- 238000002798 spectrophotometry method Methods 0.000 description 5
- 238000004062 sedimentation Methods 0.000 description 4
- 208000026487 Triploidy Diseases 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000006837 decompression Effects 0.000 description 3
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 241000218377 Magnoliaceae Species 0.000 description 1
- 241000736078 Schisandra sphenanthera Species 0.000 description 1
- 102000011759 adducin Human genes 0.000 description 1
- 108010076723 adducin Proteins 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Images
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100415664A CN100465183C (en) | 2006-09-15 | 2006-09-15 | Method of comprehensive utilizing schisandra fruit |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100415664A CN100465183C (en) | 2006-09-15 | 2006-09-15 | Method of comprehensive utilizing schisandra fruit |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1927873A CN1927873A (en) | 2007-03-14 |
CN100465183C true CN100465183C (en) | 2009-03-04 |
Family
ID=37858026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2006100415664A Expired - Fee Related CN100465183C (en) | 2006-09-15 | 2006-09-15 | Method of comprehensive utilizing schisandra fruit |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100465183C (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101766690B (en) * | 2010-02-24 | 2012-10-24 | 哈尔滨仁皇药业股份有限公司 | Multipurpose utilization method for improving the value of schisandra chinensis medicinal material |
CN102757510A (en) * | 2012-04-28 | 2012-10-31 | 江苏大学 | Low-molecular weight schisandra chinensis polysaccharides and preparation method and application thereof |
CN102920783B (en) * | 2012-11-14 | 2014-05-07 | 沈阳药科大学 | Process for preparing effective components of schisandrachinensis |
CN105287729A (en) * | 2014-07-29 | 2016-02-03 | 西安旭煌生物技术有限公司 | Novel method for extracting polysaccharides and total lignans from schisandra chinensis |
CN107773610A (en) * | 2016-08-25 | 2018-03-09 | 吉林省跨海生化药业制造有限公司 | A kind of Chinese medicine composition and its preparation to chemical damage with auxiliary protection function |
CN107595695A (en) * | 2017-09-13 | 2018-01-19 | 李德海 | A kind of extracting method of Schisandra chinens P.E and its application |
CN109021129B (en) * | 2018-07-10 | 2021-01-08 | 广西壮族自治区药用植物园 | Method for extracting black tiger fruit polysaccharide |
CN112057500A (en) * | 2020-10-16 | 2020-12-11 | 陕西嘉禾药业有限公司 | Method for extracting polysaccharide, volatile oil, flavone and lignan from schisandra chinensis |
CN112791137B (en) * | 2020-12-30 | 2023-07-04 | 沈嘉 | Three shizandra berry extracts and preparation process and application thereof |
-
2006
- 2006-09-15 CN CNB2006100415664A patent/CN100465183C/en not_active Expired - Fee Related
Non-Patent Citations (10)
Title |
---|
Liquid chromatographic analysis of supercritical carbondioxideextracts of Schizandra chinensis. Milena Bartlova et al.Journal of Chromatography B,Vol.770 . 2002 |
Liquid chromatographic analysis of supercritical carbondioxideextracts of Schizandra chinensis. Milena Bartlova et al.Journal of Chromatography B,Vol.770 . 2002 * |
五味子不同提取工艺活性成分的研究. 田明等.制剂研究,第20卷第4期. 2003 |
五味子不同提取工艺活性成分的研究. 田明等.制剂研究,第20卷第4期. 2003 * |
五味子多糖提取纯化、分级及应用. 韩学忠.中医药学报,第33卷第6期. 2005 |
五味子多糖提取纯化、分级及应用. 韩学忠.中医药学报,第33卷第6期. 2005 * |
五味子粗多糖提取工艺的研究. 李巧云等.食品科学,第25卷第5期. 2004 |
五味子粗多糖提取工艺的研究. 李巧云等.食品科学,第25卷第5期. 2004 * |
五味子药材不同提取方法的HPLC 指纹图谱分析. 范卓文等.东北师大学报自然科学版,第36卷第2期. 2004 |
五味子药材不同提取方法的HPLC 指纹图谱分析. 范卓文等.东北师大学报自然科学版,第36卷第2期. 2004 * |
Also Published As
Publication number | Publication date |
---|---|
CN1927873A (en) | 2007-03-14 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Jiangsu Zhongxing Pharmaceutical Co., Ltd. Assignor: Jiangsu University Contract fulfillment period: 2009.12.8 to 2016.12.8 Contract record no.: 2009320001776 Denomination of invention: Method of comprehensive utilizing schisandra fruit Granted publication date: 20090304 License type: Exclusive license Record date: 20091221 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.12.8 TO 2016.12.8; CHANGE OF CONTRACT Name of requester: JIANGSU ZHONGXING PHARMACEUTICAL CO., LTD. Effective date: 20091221 |
|
EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Jiangsu Zhongxing Pharmaceutical Co., Ltd. Assignor: Jiangsu University Contract record no.: 2009320001776 Date of cancellation: 20111215 |
|
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20070314 Assignee: Jiangsu Zhongxing Pharmaceutical Co., Ltd. Assignor: Jiangsu University Contract record no.: 2013320000414 Denomination of invention: Method of comprehensive utilizing schisandra fruit Granted publication date: 20090304 License type: Exclusive License Record date: 20130507 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Jiangsu Zhongxing Pharmaceutical Co., Ltd. Assignor: Jiangsu University Contract record no.: 2013320000414 Date of cancellation: 20161021 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090304 Termination date: 20180915 |
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CF01 | Termination of patent right due to non-payment of annual fee |