CN112263614A - Compound codonopsis pilosula buccal tablet for enhancing immune function of women and preparation method thereof - Google Patents
Compound codonopsis pilosula buccal tablet for enhancing immune function of women and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a compound codonopsis pilosula buccal tablet for enhancing the immune function of women and a preparation method thereof, belonging to the technical field of traditional Chinese medicine health products. The compound radix codonopsitis buccal tablet consists of main materials and auxiliary materials according to the weight ratio of 1: 0.25-0.35; the main materials comprise the following components in parts by weight: 40-60 parts of codonopsis pilosula, 15-35 parts of astragalus membranaceus, 15-25 parts of kudzu roots, 10-15 parts of Chinese dates and 5-10 parts of roses; the auxiliary materials comprise, by weight, 55-75 parts of anhydrous lactose, 25-40 parts of microcrystalline cellulose and 0.2-0.5 part of stevioside serving as a flavoring agent. The compound codonopsis pilosula buccal tablet is developed based on the traditional Chinese medicine health care and health preserving theory, has scientific and reasonable formula, simple preparation process, safety, stability and effectiveness, has the health care function of enhancing immunity, and is more suitable for women.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine health products, in particular to a compound radix codonopsitis buccal tablet for enhancing the immunologic function of women and a preparation method thereof.
Background
With the progressive progress and development of society, the life rhythm of people is accelerated, and sub-health people are more and more. Sub-health refers to a state between health and disease, and the most basic and core problem is the low autoimmune function of human body. The deficiency syndrome in traditional Chinese medicine refers to the pathological generalization of various clinical manifestations caused by deficiency of vital qi, weakened body resistance to pathogens and hypofunction of physiology, which is the pathological condition of body infection with pathogenic qi, consistent with the condition of hypoimmunity. People who stay up often, work pressure is big, chronic disease patient, middle-aged and old people, children and pregnant women provide wide development space for development of health care products for enhancing immunity.
Radix Codonopsis is also called radix Codonopsis, Ginseng radix, lion head Ginseng, radix Codonopsis, and ZHONGLING grass, and is dried root of Codonopsis pilosula (Franch.) of Campanulaceae, Codonopsis pilosula Nannf.var.modesta (Nannf.) or Codonopsis tandshun Oliv.of Codonopsis. Dang Shen is neutral in nature and sweet in flavor, and can enter spleen and lung meridians to tonify middle-jiao and Qi. The book of materia Medica: invigorating spleen without dryness, nourishing stomach yin without dampness, moistening lung without cold or cool, nourishing blood without greasy taste, inspiring yang, vibrating middle-jiao energy without the disadvantage of dryness. Modern pharmacological studies show that the codonopsis pilosula can enhance the immunologic function of a human body, and has the effects of resisting fatigue, reducing blood pressure, resisting ulcer and the like.
The radix astragali is dried root of Astragalus membranaceus (Fisch.) Bge. of Leguminosae family or Astragalus membranaceus (Fisch.) Bge. of Hsiao. Sweet and warm. It enters lung and spleen meridians. Invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, removing stagnation, relieving arthralgia, expelling toxin, expelling pus, healing sore, and promoting granulation. The record of the materia medica preparation: to benefit primordial qi and strengthen the spleen and stomach. It is indicated for fatigue, internal injury, spleen deficiency, diarrhea, viscera prolapse, qi deficiency, blood collapse, and female metrorrhagia and metrostaxis. "Rihuazi Ben Cao" helps qi and strengthen the muscles and bones, and strengthens the muscles and tonifies the blood ". Modern pharmacological research shows that astragalus can enhance the immune function of the organism, resist aging, protect the liver, promote urination, reduce blood pressure and the like.
Radix Puerariae is dried root of Pueraria lobata (Willd.) Ohwi of Leguminosae. Sweet, pungent and cool. It enters spleen, stomach and lung meridians. Expelling pathogenic factors from muscles and skin, relieving fever, promoting salivation, quenching thirst, promoting eruption, invigorating yang, relieving diarrhea, dredging meridian passage, and relieving alcoholism. The record of Ben Cao Jing Shu (herbal Jing Shu): the main herbs for dispelling heat pathogen of yang-resolving and heat-resolving diseases are also known as yang-resolving and heat-rising herbs, and wind-herbs are also known as wind-herbs. "Shen nong Ben Cao Jing: diabetes, fever, vomiting, arthralgia, qi of the yin and toxicity. Modern pharmacological research shows that the kudzuvine root has the effects of reducing blood pressure, blood fat and blood sugar, resisting osteoporosis and the like. As the kudzu root powder used as both medicine and food, the kudzu root powder is called as a healthy 'umbrella', and is increasingly applied to daily health-care food.
The fructus Jujubae is dried mature fruit of Ziziphus jujuba Mill of Rhamnaceae. Sweet and warm. It enters spleen and stomach meridians. Has the effects of invigorating spleen, regulating stomach function, benefiting qi, promoting fluid production, regulating ying and wei, and removing drug toxicity. The book of Shen nong Ben Cao Jing (Shen nong's herbal) has a main expression: governing heart and abdomen pathogenic qi, pacifying spleen and assisting twelve meridians. Pacify stomach qi, unblock nine orifices, nourish qi and fluids, deficiency of body and middle energizer, severe convulsion, heaviness of limbs, and Bai Yao. Record of "Rihuazi materia Medica": moisten heart and lung, and relieve cough. Tonify five internal organs, treat deficiency and strain, and remove qi of intestine and stomach. Modern pharmacological research shows that the Chinese date has the functions of enhancing immunity, resisting tumor, resisting oxidation, protecting liver and the like. The Chinese dates are common medicine and food dual-purpose Chinese medicaments and are often used as food in daily life.
The flos Rosae Rugosae is dried flower bud of Rosa rugosa Thunb. Sweet, slightly bitter and warm. It enters liver and spleen meridians. Has effects in promoting qi circulation, relieving depression, regulating blood circulation, and relieving pain. The book of materia Medica: the rose flower has the most intense fragrance, is clear but not turbid, is mild but not violent, can soften the liver and wake the stomach, can promote qi circulation and invigorate blood circulation, can dredge qi and suffocate stasis without the disadvantage of pungent, warm and hard dryness, has the most rapid effect and is the most excellent in medicine division by pushing away qi, and has almost no fragrance. "supplement of compendium of materia Medica": to harmonize blood, promote blood circulation and regulate qi. It is indicated for arthralgia due to wind-cold. The modern pharmacological research shows that the rose has the therapeutic effect on central nervous system diseases, cardiovascular diseases, tumors and the like.
At present, no buccal tablet compounded by the formula exists, and the astragalus and the codonopsis pilosula have high fiber and strong powder property, so that the production process has many difficulties.
Disclosure of Invention
The invention aims to provide a compound codonopsis pilosula buccal tablet for enhancing the immune function of women and a preparation method thereof aiming at the defects of the prior art.
The purpose of the invention is realized by the following technical scheme: a female compound radix codonopsis buccal tablet for enhancing immunity function comprises a main material and an auxiliary material according to a weight ratio of 1: 0.25-0.35; the main materials comprise the following components in parts by weight: 40-60 parts of codonopsis pilosula, 15-35 parts of astragalus membranaceus, 15-25 parts of kudzu roots, 10-15 parts of Chinese dates and 5-10 parts of roses; the auxiliary materials comprise, by weight, 55-75 parts of anhydrous lactose, 25-40 parts of microcrystalline cellulose and 0.2-0.5 part of stevioside serving as a flavoring agent.
The invention also provides a preparation method of the compound codonopsis pilosula buccal tablet for enhancing the immune function of women, which comprises the following steps:
(1) crushing: weighing 40-60 parts by weight of codonopsis pilosula, 10-30 parts by weight of astragalus, 10-20 parts by weight of kudzu root, 5-15 parts by weight of Chinese date and 5-10 parts by weight of rose, mixing, and carrying out superfine grinding to obtain mixed superfine powder; the particle size of the superfine powder is below 50 mu m;
(2) mixing: weighing 55-75 parts by weight of anhydrous lactose, 25-40 parts by weight of microcrystalline cellulose and 0.2-0.5 part by weight of stevioside serving as a flavoring agent, mixing to form an auxiliary material, and uniformly mixing the superfine mixed powder obtained in the step (1) and the auxiliary material according to the weight ratio of 1: 0.25-0.35;
(3) and (3) granulating: mixing, granulating with 50-70% Mel water solution, sieving with 18 mesh sieve, oven drying for 2 hr, and grading with 24-80 mesh sieve; spraying menthol solution on the surface of the prepared granules, and uniformly stirring; spraying 2-5mL of menthol solution on every 100g of particles;
(4) tabletting: and then adding magnesium stearate with the weight percentage of 0.8-1.3% of the granules, uniformly mixing, and tabletting to obtain the compound radix codonopsitis buccal tablet.
Further, the menthol solution in the step (3) is prepared by dissolving peppermint oil in 95% edible ethanol by volume fraction to prepare 1% menthol ethanol solution by volume fraction.
Compared with the prior art, the invention has the beneficial effects that: the rose and the red date contained in the compound radix codonopsitis buccal tablet have the functions of enriching blood and beautifying, and the compound radix codonopsitis buccal tablet has the health care functions of soothing liver and resolving depression, enriching blood and beautifying and enhancing immunity when being used in the radix codonopsitis buccal tablet, and is particularly suitable for modern women with large working pressure and in sub-health for a long time. The preparation method of the compound radix codonopsitis buccal tablet is simple and easy to popularize.
Detailed Description
Example 1
The invention provides a preparation method of compound codonopsis pilosula buccal tablets for enhancing immune function of women, which comprises the following steps:
(1) crushing: weighing 40g of codonopsis pilosula, 10g of astragalus membranaceus, 10g of kudzuvine root, 5g of Chinese date and 5g of rose, mixing, carrying out superfine grinding, and sieving by using a 100-mesh sieve to obtain mixed superfine powder; the particle size of the superfine powder is below 50 mu m;
(2) mixing: weighing 55g of anhydrous lactose, 25g of microcrystalline cellulose and 0.2g of stevioside serving as a flavoring agent, mixing to form an auxiliary material, and uniformly mixing the mixed superfine powder obtained in the step (1) and the auxiliary material according to the weight ratio of 1: 0.25;
(3) and (3) granulating: mixing uniformly, granulating with 50% Mel water solution, sieving with 18 mesh sieve, oven drying at 60 deg.C for 2 hr, and grading with 24-80 mesh sieve; spraying menthol solution on the surface of the prepared granules, and uniformly stirring; spraying 2mL of menthol solution on every 100g of particles; the menthol ethanol solution is prepared by dissolving peppermint oil in 95% edible ethanol by volume fraction to prepare 1% menthol ethanol solution by volume fraction.
(4) Tabletting: and then adding magnesium stearate with the weight percentage of 0.8 percent of the granules, uniformly mixing, and tabletting to obtain the compound radix codonopsitis buccal tablet.
BALB/c mice were fed with the compound Codonopsis pilosula buccal tablets of this example at a dose of 600mg/kg for 1 time a day for four weeks. Observing the influence of the compound radix codonopsitis buccal tablet on the weight, immune organs, NK cell activity, spleen T and B lymphocyte proliferation capacity, delayed type hypersensitivity, antibody level, clearance index and phagocytosis index of BALB/c mice. Experimental results show that the compound codonopsis pilosula buccal tablets can obviously increase thymus index of a normal mouse, increase activity of NK cells of the spleen of the mouse, enhance clearance index and phagocytosis index of the normal mouse, and enhance proliferation capacity of T lymphocytes of the spleen induced by ConA and proliferation capacity of B lymphocytes of the spleen induced by LPS.
Example 2
The invention provides a preparation method of compound codonopsis pilosula buccal tablets for enhancing immune function of women, which comprises the following steps:
(1) crushing: weighing 60g of codonopsis pilosula, 30g of astragalus mongholicus, 20g of radix puerariae, 15g of Chinese dates and 10g of rose, mixing, carrying out superfine grinding, and sieving by using a 100-mesh sieve to obtain mixed superfine powder; the particle size of the superfine powder is below 50 mu m;
(2) mixing: weighing 75g of anhydrous lactose, 40g of microcrystalline cellulose and 0.5g of flavoring agent stevioside, mixing to form an auxiliary material, and uniformly mixing the mixed superfine powder obtained in the step (1) and the auxiliary material according to the weight ratio of 1: 0.35;
(3) and (3) granulating: after uniformly mixing, granulating by using a honey water solution with the mass/volume fraction of 70%, sieving by using a 18-mesh sieve, drying for 2 hours, and then grading by using a 80-mesh sieve; spraying menthol solution on the surface of the prepared granules, and uniformly stirring; 5mL of menthol solution is sprayed on every 100g of particles;
(4) tabletting: and then adding magnesium stearate with the weight percentage of 1.3 percent of the granules, uniformly mixing, and tabletting to obtain the compound radix codonopsitis buccal tablet.
BALB/c mice were fed with the compound Codonopsis pilosula buccal tablets of this example at a dose of 600mg/kg for 1 time a day for four weeks. Observing the influence of the compound radix codonopsitis buccal tablet on the weight, immune organs, NK cell activity, spleen T and B lymphocyte proliferation capacity, delayed type hypersensitivity, antibody level, clearance index and phagocytosis index of BALB/c mice. Experimental results show that the compound codonopsis pilosula buccal tablets can obviously increase thymus index of a normal mouse, increase activity of NK cells of the spleen of the mouse, enhance clearance index and phagocytosis index of the normal mouse, and enhance proliferation capacity of T lymphocytes of the spleen induced by ConA and proliferation capacity of B lymphocytes of the spleen induced by LPS.
Claims (3)
1. A female compound radix codonopsitis buccal tablet for enhancing immunity function is characterized in that the compound radix codonopsitis buccal tablet is composed of a main material and an auxiliary material according to the weight ratio of 1: 0.25-0.35; the main materials comprise the following components in parts by weight: 40-60 parts of codonopsis pilosula, 15-35 parts of astragalus membranaceus, 15-25 parts of kudzu roots, 10-15 parts of Chinese dates and 5-10 parts of roses; the auxiliary materials comprise, by weight, 55-75 parts of anhydrous lactose, 25-40 parts of microcrystalline cellulose and 0.2-0.5 part of stevioside serving as a flavoring agent.
2. A method for preparing the compound codonopsis pilosula buccal tablet of claim 1, which is characterized by comprising the following steps:
(1) crushing: weighing 40-60 parts by weight of codonopsis pilosula, 10-30 parts by weight of astragalus, 10-20 parts by weight of kudzu root, 5-15 parts by weight of Chinese date and 5-10 parts by weight of rose, mixing, and carrying out superfine grinding to obtain mixed superfine powder; the particle size of the superfine powder is below 50 mu m;
(2) mixing: weighing 55-75 parts by weight of anhydrous lactose, 25-40 parts by weight of microcrystalline cellulose and 0.2-0.5 part by weight of stevioside serving as a flavoring agent, mixing to form an auxiliary material, and uniformly mixing the superfine mixed powder obtained in the step (1) and the auxiliary material according to the weight ratio of 1: 0.25-0.35;
(3) and (3) granulating: mixing, granulating with 50-70% Mel water solution, sieving with 18 mesh sieve, oven drying for 2 hr, and grading with 24-80 mesh sieve; spraying menthol solution on the surface of the prepared granules, and uniformly stirring; spraying 2-5mL of menthol solution on every 100g of particles;
(4) tabletting: and then adding magnesium stearate with the weight percentage of 0.8-1.3% of the granules, uniformly mixing, and tabletting to obtain the compound radix codonopsitis buccal tablet.
3. A method for preparing the compound codonopsis pilosula buccal tablet according to claim 2, wherein the menthol solution in the step (3) is prepared by dissolving peppermint oil in 95 volume percent edible ethanol to prepare 1 volume percent menthol solution.
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Cited By (2)
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CN113229497A (en) * | 2021-05-13 | 2021-08-10 | 山东译青春生物科技有限公司 | Food formula for improving female energy and preparation method thereof |
CN114949031A (en) * | 2021-02-26 | 2022-08-30 | 湖州新活医疗科技有限公司 | Traditional Chinese medicine composition for improving spleen and stomach functions and enhancing immunity and application |
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Non-Patent Citations (1)
Title |
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季屹红等: "补康灵对环磷酰胺模型小鼠造血和免疫功能的影响", 《中华中医药学刊》 * |
Cited By (2)
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CN114949031A (en) * | 2021-02-26 | 2022-08-30 | 湖州新活医疗科技有限公司 | Traditional Chinese medicine composition for improving spleen and stomach functions and enhancing immunity and application |
CN113229497A (en) * | 2021-05-13 | 2021-08-10 | 山东译青春生物科技有限公司 | Food formula for improving female energy and preparation method thereof |
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