CN1593484A - Bone strengthening granule of tortoise plastron and astragalus root - Google Patents
Bone strengthening granule of tortoise plastron and astragalus root Download PDFInfo
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- CN1593484A CN1593484A CNA2004100109462A CN200410010946A CN1593484A CN 1593484 A CN1593484 A CN 1593484A CN A2004100109462 A CNA2004100109462 A CN A2004100109462A CN 200410010946 A CN200410010946 A CN 200410010946A CN 1593484 A CN1593484 A CN 1593484A
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Abstract
The invention discloses a bone strengthening granule of tortoise plastron and astragalus root, which is prepared from prepared rehmannia root, tortoise shell, eucommia bark, psoralea fruit, walnut kernel, astragalus root, rhizoma dioscoreae, white atractylodes rhizome, Chinese angelica root, wolferry fruit, fleece-flower root, ligustrum japonicum, cornus officinalis, Bupleurum root, root of red rooted saliva, Ligusticum wallichii1, safflower, pollen through modern processing steps.
Description
Technical field:
The present invention relates to the Chinese medicine preparation of nourishing the liver and kidney, activating blood circulation to dissipate blood stasis, bone and muscle strengthening, say it is to disclose a kind of Testudinis stilbene bone-strengthening grain Chinese medicine preparation exactly, belong to traditional Chinese medical science pharmaceutical technology field.
Background technology:
Deficiency of kidney-essence can cause the lumbago deficiency of vital energy, and is bleary-eyed dizzy, forgetful weak, soreness of the waist and knees, knowledge is become deaf, vexed dreaminess, diseases such as seminal emission, the kidney invigorating medicine commonly used adopts famous and precious Chinese herbal medicine or the positive tool of animal mostly, the cost of medicine is higher, and patient economy burden is excessive, and curative effect is not remarkable yet, even the medicine that has also has very big toxic and side effects, influenced the treatment of deficiency of the kidney disease of patient.
Summary of the invention:
The invention provides a kind of Testudinis stilbene bone-strengthening grain Chinese medicine preparation, have evident in efficacy, cheap, the characteristics that toxic and side effects is little.
Theory of Chinese medical science according to motherland thinks, lumbago is based on deficiency of the kidney, have concurrently insufficiency of the spleen, qi depression to blood stasis, so the present invention adopts nourishing the liver and kidney, invigorating the spleen and benefiting QI, blood circulation promoting and blood stasis dispelling, bone and muscle strengthening is the treatment legislation, and the pure Chinese herbal medicine of selected following all flavors is made by traditional Chinese medicine processing technology.Concrete prescription following (by ratio of weight and the number of copies):
Radix Rehmanniae Preparata 8～12, Carapax Et Plastrum Testudinis 1～2, the Cortex Eucommiae 8～12, Fructus Psoraleae 8～12, Semen Juglandis 9～11, the Radix Astragali 8～12, Rhizoma Dioscoreae 9～10, the Rhizoma Atractylodis Macrocephalae 9～11, Radix Angelicae Sinensis 9～10, Fructus Lycii 8～12, Radix Polygoni Multiflori 10～11, Fructus Ligustri Lucidi 9～11, Fructus Corni 10～12, Radix Bupleuri 10～11, Radix Salviae Miltiorrhizae 8～10, Rhizoma Chuanxiong 9～11, Flos Carthami 9～11, pollenin 25～35.
Optimum ratio of the present invention is (ratio of weight and number):
Radix Rehmanniae Preparata 10, Carapax Et Plastrum Testudinis 1, the Cortex Eucommiae 10, Fructus Psoraleae 10, Semen Juglandis 10, the Radix Astragali 10, Rhizoma Dioscoreae 10, the Rhizoma Atractylodis Macrocephalae 10, Radix Angelicae Sinensis 10, Fructus Lycii 10, Radix Polygoni Multiflori 10, Fructus Ligustri Lucidi 10, Fructus Corni 10, Radix Bupleuri 10, Radix Salviae Miltiorrhizae 10, Rhizoma Chuanxiong 10, Flos Carthami 10, pollenin 30.
Concrete processing procedure is as follows: take by weighing above-mentioned 18 herbal medicines in proportion, except that Fructus Ligustri Lucidi, all the other are ground into coarse powder, with 6～9 times of alcohol reflux 2～4 times, and each 2 hours, merging filtrate, being concentrated into relative density and being 1.22～1.25 (60 ℃), to add ethanol be to contain the alcohol amount to reach 60～80%, static 24 hours, gets supernatant, reclaim ethanol, the extractum that is concentrated into relative density and is 1.35～1.38 (60 ℃) is stand-by; Get Fructus Ligustri Lucidi powder and be broken into coarse powder with 6～8 times 65% alcohol reflux 2～3 times, each 2 hours, merge extractive liquid, filtered, reclaim ethanol, being concentrated into relative density is the extractum of 1.35～1.38 (60 ℃), with above-mentioned two kinds of extractum mixing and stirring, adds 45～55 parts of starch, 20～25 parts of mixings of sucrose, with an amount of mixing granulation of ethanol, drying, granulate, packing is made medicine of the present invention.
[character] this product is the granule of pale brown color or brown; Sweet, the little hardship, sour and astringent of distinguishing the flavor of.
[function cures mainly] QI invigorating is enriched blood, nourishing the liver and kidney, activating blood circulation to dissipate blood stasis, bone and muscle strengthening.Be applicable to diseases such as soreness of the waist and knees, insufficiency of vital energy and blood.
[usage and dosage] boiled water is taken after mixing it with water, a 10g, 2 times on the one.5g of under-18s, take 30 minutes ante cibum.
Selecting monarch drug among the side of the present invention is Radix Rehmanniae Preparata severe excess syndrome kidney essense, and packing bone marrow is the key medicine of flat nourishing YIN YANG-fire; Carapax Et Plastrum Testudinis is the in love product of flesh and blood, makes its smart giving birth to and gas is prosperous, kidney storing essence, and blood stored in the liver, kidney governing bones, liver governing tendons, the two is the principal agent nourish liver and kidney altogether, strengthening the tendons and bones is with Tu Qiben.Minister can the kidney invigorating moisten liver, warming the kidney to activate YANG, removing damp and stopping pain with the Cortex Eucommiae.The Fructus Psoraleae kidney invigorating and YANG supporting, except that air-cooled, strong spinal column.Semen juglandis the kidney invigorating warming YANG, benefiting essence-blood, strong waist knee joint.Three medicines must be joined, and auxilliary monarch can strengthen the merit of nourishing the liver and kidney.Use the Radix Astragali, Rhizoma Chuanxiong, Flos Carthami strengthening the spleen tonifying the lung again, rouse oneself Yuanyang, the sending up the lucid YANG blood circulation promoting and blood stasis dispelling.Rhizoma Atractylodis Macrocephalae spleen invigorating stomach strengthening, the dampness diuretic.The Rhizoma Dioscoreae reinforcing spleen and kidney, replenishing vital QI with drugs of warm nature muscle.Fructus Lycii tonifying liver blood, the kidney tonifying essence.The Radix Polygoni Multiflori blood enriching and generation of vital essence promoting, strong muscles and bones.The Fructus Ligustri Lucidi nourish liver and kidney, controlling nocturnal emission with astringent drugs kidney tonifying, reducing the asthenic fever, Pingyin fire.The Fructus Corni benefiting essence-blood is transferred irritability, promoting blood circulation, and the bone strengthening marrow, it is prosperous without obstacle that described Six-element gets QI and blood, is the also favourable condition of wound that wets by wind and cold, the anxiety that no numbness the moon is reluctant to leave.Reuse Radix Bupleuri, Radix Salviae Miltiorrhizae nourishing YIN to lower pathogenic fire, the asthenic fire that disappears, damp eliminating heat.Make with the invigorating middle warmer of pollen QI invigorating, moisturize detoxifcation, and the harmonic group medicine.
Good effect of the present invention is: medicine is a pure Chinese medicinal preparation, has no side effect, and is evident in efficacy, and all medicine contracts have eliminating pathogenic factor for supporting vital QI and lay equal stress on, fill blood, and the liver and kidney tonifying spleen, the effect of activating blood circulation to dissipate blood stasis, for lumbar and back pain, self energy obtains recovery from illness.
For showing the therapeutic effect of medicine of the present invention, the patient of 80 routine lumbar and back pain is used the treatment of Testudinis stilbene bone-strengthening grain, obtained promising result, now be summarized as follows:
One, physical data
This organizes 80 routine patients, male 30 examples, and women 50 examples, 60 years old the highest age, 22 years old minimum age, 18 examples of wherein working, peasant's 10 examples, cadre's 50 examples, student's 2 examples, the course of disease two months at least, the elder reaches 12 years.
This group patient all by the clinical research of this medicine in the works diagnostic criteria be selected into the observation case, insufficiency of kidney-YANG accounts for 64 examples in 80 examples, deficiency of the kidney yin accounts for 16 examples.
Two, case is selected
All is the painful patient in back that suffers from a deficiency of the kidney, and card is seen: lumbar and back pain, and soreness of the waist and knees dare not be changed one's position, pain in fixed position, desire for being robbed and pressed, hands and feet being not warm or dysphoria with feverish sensation in the chest palms and soles are had a sleepless night and are slept less, and dryness of the mouth and throat, constipation are main clinical manifestation person, all can include case in.
Three, Chinese medical discrimination
Nephrasthenia syndrome:
Main symptom: waist is aching and limp or continuously have a pain, and desire for being robbed and pressed is met Lao Zechong, for sleeping in then alleviation of pain.
Inferior card: soreness of the waist and knees is unable, or cramp and pain in the lower abdomen, hands and feet being not warm, or dysphoria with feverish sensation in the chest palms and soles, and dryness of the mouth and throat is slept in insomnia less.
The tongue arteries and veins: tongue fur, a little less than the deficient and thready pulse.Yang deficiency person's red tongue partially, stringy,thready and rapid pulse, more than each pattern of syndrome, every main symptom and corresponding tongue arteries and veins can determine that inferior card needn't be known tool.
Blood stasis symptom:
Main symptom: lumbago is as thorn, and sore spot is fixing not to move tenderness.
Inferior card: light disease pitching is unfavorable, the acute unable to move around of serious symptom pain, or wound is arranged, the history of exerting oneself.
The tongue arteries and veins: purplish tongue, or ecchymosis is arranged, hesitant pulse.
Four, state of an illness grade scale
Slightly: the lumbago idol has outbreak, has a dull ache, and does not influence operate as normal.
Moderate: lumbago is heavier, and it is unfavorable to change one's position, inconvenient activity, or lumbago is indistinct, outbreak again and again, even influence work.
Severe: waist severe pain, unable to move around, it is acute to play the movable pain of seat, can not adhere to work, or lumbago is continuous, continues person more than 1 month.
Five, observational technique
1, adopts Self-control method, promptly, compare observation self medication front and back symptom.
2, all MethodsThe cases enrolled, the routine urinalysis of before and after medication, having a blood test respectively, part patient looks into liver function, kidney merit respectively; Other stop using during the treatment about medicine, and after finishing the course of treatment, its result carries out statistical procedures.
3, observe medicine and medication.
" Testudinis stilbene bone-strengthening grain " provided by Jilin Province Dunhua Ruilong Pharmaceutical Co., Ltd..
Medication: oral, each 10 grams are taken after mixing it with water for 2 times every day, and 30 days is 1 course of treatment.
Six, observed result
1, curative effect determinate standard (summary).
2, treatment observed result: in 80 examples, produce effects 30 examples account for 37.5%; Effective 46 examples account for 57.5%; Invalid 4 examples account for 5%, total effective rate 95%.
After controlling before controlling
Symptom n u p
+++ ++ + - +++ ++ + -
Lumbar and back pain 80 42 32 600 16 56 8 2.777＜0.01
Soreness of the waist and knees 80 20 36 20 406 50 24 2.289＜0.05
Dare not change one's position 80 66 26 42 00 16 64 1.151＞0.05
Pain in fixed position 80 4 18 20 38 04 16 60 1.154＞0.05
Desire for being robbed and pressed 80 6 38 30 60 10 28 42 2.004＞0.05
Hands and feet being not warm 80 6 14 16 28 04 12 64 1.666＞0.05
Dysphoria with feverish sensation in the chest palms and soles 80 22 20 56 004 76 1.200＞0.05
Insomnia sleeps 80 2 24 18 36 06 20 54 1.020＞0.05 less
Dryness of the mouth and throat 80 02 26 52 008 72 1.092＞0.05
Constipation 80 02 20 58 002 78 2.538＜0.05
Clear urine in large amounts 80 06 20 54 00 10 70 0.903＞0.05
Conclusion: can improve and alleviate most of clinical card shape.Not obvious to constipation, insomnia, dysphoria with feverish sensation in the chest palms and soles, improvement.
Seven, safety detects
80 routine patients do not find obvious toxic-side effects after treatment, hematuria routine before and after the medication in 80 examples, and wherein liver function, all no abnormal change of kidney merit inspection before and after 30 routine patient's medications proves this product safety non-toxic.
Eight, brief summary
Through above 80 routine clinical observations, Testudinis stilbene bone-strengthening grain truly has the function of nourishing the liver and kidney, bone and muscle strengthening to the treatment lumbar and back pain, especially obvious with deficiency of the kidney yin case effect, but relief of symptoms, total effective rate reaches 95%, experiment is also observed and is taken this product to aspects such as hemogram, heart rate, blood pressure, liver function, kidney merits, does not all find obviously to pay effect and untoward reaction, does not also find other untoward reaction.
The specific embodiment:
The following example is intended to further describe for example the present invention, rather than limits the present invention by any way.Under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall within the claim scope of the present invention.
Embodiment 1:
Take by weighing Radix Rehmanniae Preparata 100g, Carapax Et Plastrum Testudinis 10g, Cortex Eucommiae 100g, Fructus Psoraleae 100g, Semen Juglandis 100g, Radix Astragali 100g, Rhizoma Dioscoreae 100g, Rhizoma Atractylodis Macrocephalae 100g, Radix Angelicae Sinensis 100g, Fructus Lycii 100g, Radix Polygoni Multiflori 100g, Fructus Corni 100g, Radix Bupleuri 100g, Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 100g, Flos Carthami 100g, pollenin 300g, remove impurity, after pulverize separately becomes coarse powder, with 8 times of alcohol reflux 3 times, each 2 hours, merging filtrate, being concentrated into relative density and being 1.22～1.25 (60 ℃), to add ethanol be to contain the alcohol amount to reach 70%, static 24 hours, get supernatant, reclaim ethanol, the extractum that is concentrated into relative density and is 1.35～1.38 (60 ℃) is stand-by; Get Fructus Ligustri Lucidi 100g and be ground into coarse powder with 8 times 65% alcohol reflux 3 times, each 2 hours, merge extractive liquid, filtered, reclaim ethanol, being concentrated into relative density is the extractum of 1.35～1.38 (60 ℃), with above-mentioned two kinds of extractum mixing and stirring, adds starch 500g, sucrose 250g mixing, with an amount of mixing granulation of ethanol, drying, granulate, packing is made medicine of the present invention.
Embodiment 2:
Take by weighing Radix Rehmanniae Preparata 85g, Carapax Et Plastrum Testudinis 10g, Cortex Eucommiae 105g, Fructus Psoraleae 90g, Semen Juglandis 110g, Radix Astragali 90g, Rhizoma Dioscoreae 95g, Rhizoma Atractylodis Macrocephalae 100g, Radix Angelicae Sinensis 100g, Fructus Lycii 120g, Radix Polygoni Multiflori 100g, Fructus Corni 100g, Radix Bupleuri 110g, Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 90g, Flos Carthami 100g, pollenin 330g, remove impurity, after pulverize separately becomes coarse powder, with 8 times of alcohol reflux 3 times, each 2 hours, merging filtrate, being concentrated into relative density and being 1.22～1.25 (60 ℃), to add ethanol be to contain the alcohol amount to reach 70%, static 24 hours, get supernatant, reclaim ethanol, the extractum that is concentrated into relative density and is 1.35～1.38 (60 ℃) is stand-by; Get Fructus Ligustri Lucidi 100g and be ground into coarse powder with 8 times 65% alcohol reflux 3 times, each 2 hours, merge extractive liquid, filtered, reclaim ethanol, being concentrated into relative density is the extractum of 1.35～1.38 (60 ℃), with above-mentioned two kinds of extractum mixing and stirring, adds starch 500g, sucrose 250g mixing, with an amount of mixing granulation of ethanol, drying, granulate, packing is made medicine of the present invention.
Claims (3)
1, a kind of Testudinis stilbene bone-strengthening grain is characterized in that being made by the following portions by weight proportion raw material:
Radix Rehmanniae Preparata 8～12, Carapax Et Plastrum Testudinis 1～2, the Cortex Eucommiae 8～12, Fructus Psoraleae 8～12, Semen Juglandis 9～11,
The Radix Astragali 8～12, Rhizoma Dioscoreae 9～10, the Rhizoma Atractylodis Macrocephalae 9～11, Radix Angelicae Sinensis 9～10, Fructus Lycii 8～12,
Radix Polygoni Multiflori 10～11, Fructus Ligustri Lucidi 9～11, Fructus Corni 10～12, Radix Bupleuri 10～11,
Radix Salviae Miltiorrhizae 8～10, Rhizoma Chuanxiong 9～11, Flos Carthami 9～11, pollenin 25～35.
2, Chinese medicine preparation according to claim 1 is characterized in that it being to be made by the following portions by weight proportion raw material:
Radix Rehmanniae Preparata 10, Carapax Et Plastrum Testudinis 1, the Cortex Eucommiae 10, Fructus Psoraleae 10, Semen Juglandis 10,
The Radix Astragali 10, Rhizoma Dioscoreae 10, the Rhizoma Atractylodis Macrocephalae 10, Radix Angelicae Sinensis 10, Fructus Lycii 10,
Radix Polygoni Multiflori 10, Fructus Ligustri Lucidi 10, Fructus Corni 10, Radix Bupleuri 10, Radix Salviae Miltiorrhizae 10,
Rhizoma Chuanxiong 10, Flos Carthami 10, pollenin 30.
3, the processing procedure controlled of Chinese medicine according to claim 1 and 2 may further comprise the steps: take by weighing above-mentioned 18 herbal medicines in proportion, except that Fructus Ligustri Lucidi, all the other are ground into coarse powder, with 6～9 times of alcohol reflux 2～4 times, each 2 hours, merging filtrate, being concentrated into relative density is 1.22～1.25, adding ethanol is to contain the alcohol amount to reach 60～80%, static 24 hours, gets supernatant, reclaim ethanol, it is stand-by to be concentrated into relative density and to be 1.35～1.38 extractum; Get Fructus Ligustri Lucidi powder and be broken into coarse powder with 6～8 times 65% alcohol reflux 2～3 times, each 2 hours, merge extractive liquid, filtered, reclaim ethanol, be concentrated into relative density and be 1.35～1.38 extractum,, add 45～55 parts of starch, 20～25 parts of mixings of sucrose above-mentioned two kinds of extractum mixing and stirring, with an amount of mixing granulation of ethanol, drying, granulate, packing is made medicine of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100109462A CN1301122C (en) | 2004-06-23 | 2004-06-23 | Bone strengthening granule of tortoise plastron and astragalus root |
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| CNB2004100109462A CN1301122C (en) | 2004-06-23 | 2004-06-23 | Bone strengthening granule of tortoise plastron and astragalus root |
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| CN1593484A true CN1593484A (en) | 2005-03-16 |
| CN1301122C CN1301122C (en) | 2007-02-21 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101020026B (en) * | 2007-03-22 | 2011-04-06 | 重庆御一药业有限公司 | Honeyed Guiqi ointment for enhancing body's resistance and its preparation |
| CN102793826A (en) * | 2012-09-04 | 2012-11-28 | 柳州市中医院 | Traditional Chinese medicine for treating hypertension early-stage kidney damage and preparation method thereof |
| CN114949079A (en) * | 2022-08-02 | 2022-08-30 | 吉林瑞隆药业有限责任公司 | Pharmaceutical composition for osteoporosis and preparation method thereof |
| CN114984131A (en) * | 2022-08-04 | 2022-09-02 | 吉林瑞隆药业有限责任公司 | Traditional Chinese medicine composition for treating degenerative bone diseases and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1453020A (en) * | 2003-05-21 | 2003-11-05 | 西安碑林药业股份有限公司 | Chinese medicine with Yang-strengthening and kidney-benefiting functions and its prepn |
-
2004
- 2004-06-23 CN CNB2004100109462A patent/CN1301122C/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101020026B (en) * | 2007-03-22 | 2011-04-06 | 重庆御一药业有限公司 | Honeyed Guiqi ointment for enhancing body's resistance and its preparation |
| CN102793826A (en) * | 2012-09-04 | 2012-11-28 | 柳州市中医院 | Traditional Chinese medicine for treating hypertension early-stage kidney damage and preparation method thereof |
| CN114949079A (en) * | 2022-08-02 | 2022-08-30 | 吉林瑞隆药业有限责任公司 | Pharmaceutical composition for osteoporosis and preparation method thereof |
| CN114984131A (en) * | 2022-08-04 | 2022-09-02 | 吉林瑞隆药业有限责任公司 | Traditional Chinese medicine composition for treating degenerative bone diseases and preparation method thereof |
| CN114984131B (en) * | 2022-08-04 | 2022-10-11 | 吉林瑞隆药业有限责任公司 | Traditional Chinese medicine composition for treating degenerative bone diseases and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1301122C (en) | 2007-02-21 |
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