CN112236421A - 吡唑衍生物和有害生物防治剂 - Google Patents
吡唑衍生物和有害生物防治剂 Download PDFInfo
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- CN112236421A CN112236421A CN201980036246.5A CN201980036246A CN112236421A CN 112236421 A CN112236421 A CN 112236421A CN 201980036246 A CN201980036246 A CN 201980036246A CN 112236421 A CN112236421 A CN 112236421A
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- 241000607479 Yersinia pestis Species 0.000 title claims abstract description 49
- 150000003217 pyrazoles Chemical class 0.000 title claims abstract description 27
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 29
- 125000005843 halogen group Chemical group 0.000 claims abstract description 28
- 150000003839 salts Chemical class 0.000 claims abstract description 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 20
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 11
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract description 10
- 239000004480 active ingredient Substances 0.000 claims abstract description 8
- 125000004434 sulfur atom Chemical group 0.000 claims abstract description 8
- -1 C1–C6Alkyl Chemical group 0.000 claims description 2486
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 357
- 150000003254 radicals Chemical class 0.000 claims description 131
- 125000000217 alkyl group Chemical group 0.000 claims description 101
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 54
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 44
- 125000004269 oxiran-2-yl group Chemical group [H]C1([H])OC1([H])* 0.000 claims description 42
- 125000004432 carbon atom Chemical group C* 0.000 claims description 21
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 20
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 16
- 125000004741 (C1-C6) haloalkylsulfonyl group Chemical group 0.000 claims description 14
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 12
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 11
- 125000006771 (C1-C6) haloalkylthio group Chemical group 0.000 claims description 10
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 10
- 125000005842 heteroatom Chemical group 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 9
- 241000196324 Embryophyta Species 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 8
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims description 8
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 7
- 125000004317 1,3,5-triazin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=N1 0.000 claims description 7
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 7
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 125000001188 haloalkyl group Chemical group 0.000 claims description 7
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 7
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 6
- 125000006772 (C1-C6) haloalkylsulfonyloxy group Chemical group 0.000 claims description 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 6
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 claims description 6
- 125000004682 aminothiocarbonyl group Chemical group NC(=S)* 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 6
- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
- 125000004043 oxo group Chemical group O=* 0.000 claims description 6
- 230000000361 pesticidal effect Effects 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
- 125000000623 heterocyclic group Chemical group 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 claims description 4
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims description 4
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 4
- 125000003627 8 membered carbocyclic group Chemical group 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 230000009418 agronomic effect Effects 0.000 claims description 4
- 125000002837 carbocyclic group Chemical group 0.000 claims description 4
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims description 4
- 239000002917 insecticide Substances 0.000 claims description 4
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims description 4
- 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 claims description 4
- 239000011593 sulfur Chemical group 0.000 claims description 4
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims description 4
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 4
- 125000005330 8 membered heterocyclic group Chemical group 0.000 claims description 3
- 125000003943 azolyl group Chemical group 0.000 claims description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 3
- 125000005646 oximino group Chemical group 0.000 claims description 3
- 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims description 3
- 125000004844 (C1-C6) alkoxyimino group Chemical group 0.000 claims description 2
- 125000004487 4-tetrahydropyranyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 2
- 238000009395 breeding Methods 0.000 claims description 2
- 230000001488 breeding effect Effects 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 239000000575 pesticide Substances 0.000 claims description 2
- 125000005400 pyridylcarbonyl group Chemical group N1=C(C=CC=C1)C(=O)* 0.000 claims description 2
- 230000006798 recombination Effects 0.000 claims description 2
- 238000005215 recombination Methods 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 972
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 505
- 125000001309 chloro group Chemical group Cl* 0.000 description 496
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 308
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 290
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 247
- 125000000131 cyclopropyloxy group Chemical group C1(CC1)O* 0.000 description 177
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 153
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 146
- YUDRVAHLXDBKSR-UHFFFAOYSA-N [CH]1CCCCC1 Chemical compound [CH]1CCCCC1 YUDRVAHLXDBKSR-UHFFFAOYSA-N 0.000 description 145
- RMRFFCXPLWYOOY-UHFFFAOYSA-N allyl radical Chemical compound [CH2]C=C RMRFFCXPLWYOOY-UHFFFAOYSA-N 0.000 description 145
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 description 145
- VMWJCFLUSKZZDX-UHFFFAOYSA-N n,n-dimethylmethanamine Chemical compound [CH2]N(C)C VMWJCFLUSKZZDX-UHFFFAOYSA-N 0.000 description 145
- 125000006412 propinylene group Chemical group [H]C#CC([H])([H])* 0.000 description 145
- 150000001875 compounds Chemical class 0.000 description 137
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 89
- LVSPDZAGCBEQAV-UHFFFAOYSA-N 4-chloronaphthalen-1-ol Chemical compound C1=CC=C2C(O)=CC=C(Cl)C2=C1 LVSPDZAGCBEQAV-UHFFFAOYSA-N 0.000 description 86
- 229920002554 vinyl polymer Polymers 0.000 description 67
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 46
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 description 36
- 239000000460 chlorine Substances 0.000 description 35
- 125000006238 prop-1-en-1-yl group Chemical group [H]\C(*)=C(/[H])C([H])([H])[H] 0.000 description 29
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 26
- 125000001352 cyclobutyloxy group Chemical group C1(CCC1)O* 0.000 description 23
- 125000003055 glycidyl group Chemical group C(C1CO1)* 0.000 description 23
- 125000001887 cyclopentyloxy group Chemical group C1(CCCC1)O* 0.000 description 22
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 19
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 16
- 125000004092 methylthiomethyl group Chemical group [H]C([H])([H])SC([H])([H])* 0.000 description 11
- 125000003545 alkoxy group Chemical group 0.000 description 10
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 10
- 150000001350 alkyl halides Chemical group 0.000 description 8
- 230000001276 controlling effect Effects 0.000 description 8
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 8
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 description 7
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 description 7
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 7
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 7
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 7
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 6
- 125000004438 haloalkoxy group Chemical group 0.000 description 6
- 125000006342 heptafluoro i-propyl group Chemical group FC(F)(F)C(F)(*)C(F)(F)F 0.000 description 6
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 6
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 6
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 6
- ZLHFONARZHCSET-UHFFFAOYSA-N 5-aminolevulinic acid hydrochloride Chemical compound Cl.NCC(=O)CCC(O)=O ZLHFONARZHCSET-UHFFFAOYSA-N 0.000 description 4
- 125000003277 amino group Chemical group 0.000 description 4
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 3
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 3
- 125000004414 alkyl thio group Chemical group 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 3
- 125000005347 halocycloalkyl group Chemical group 0.000 description 3
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- GZYVLKKMMDFCKR-UHFFFAOYSA-M 2-acetylsulfanylethyl(trimethyl)azanium;chloride Chemical compound [Cl-].CC(=O)SCC[N+](C)(C)C GZYVLKKMMDFCKR-UHFFFAOYSA-M 0.000 description 2
- 125000006022 2-methyl-2-propenyl group Chemical group 0.000 description 2
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
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- 241000255777 Lepidoptera Species 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
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- QYPPJABKJHAVHS-UHFFFAOYSA-N agmatine Chemical compound NCCCCNC(N)=N QYPPJABKJHAVHS-UHFFFAOYSA-N 0.000 description 2
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- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- SCCDDNKJYDZXMM-UHFFFAOYSA-N dimethachlor Chemical compound COCCN(C(=O)CCl)C1=C(C)C=CC=C1C SCCDDNKJYDZXMM-UHFFFAOYSA-N 0.000 description 2
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 description 2
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- 150000007524 organic acids Chemical class 0.000 description 2
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- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000003226 pyrazolyl group Chemical group 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
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- HMFHBZSHGGEWLO-YQWWZGPCSA-N (2r,4r,5r)-5-(hydroxymethyl)oxolane-2,3,4-triol Chemical compound OC[C@H]1O[C@@H](O)C(O)[C@H]1O HMFHBZSHGGEWLO-YQWWZGPCSA-N 0.000 description 1
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- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 description 1
- FNAMRDZHKYQEBA-YDQNNXAVSA-N methyl (2e,5z)-7-[(1r,2r,3r,5s)-2-[(e,3r)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hepta-2,5-dienoate Chemical compound COC(=O)\C=C\C\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(Cl)=C1 FNAMRDZHKYQEBA-YDQNNXAVSA-N 0.000 description 1
- AXOJRQLKMVSHHZ-UHFFFAOYSA-N methyl 1-methyl-1,2,3,6-tetrahydropyridin-1-ium-5-carboxylate;bromide Chemical compound Br.COC(=O)C1=CCCN(C)C1 AXOJRQLKMVSHHZ-UHFFFAOYSA-N 0.000 description 1
- NHPPWKIWKNUHSS-UHFFFAOYSA-N methyl 4-(N-(2-methoxyacetyl)anilino)-1-(2-thiophen-2-ylethyl)piperidine-4-carboxylate oxalic acid Chemical compound OC(=O)C(O)=O.COCC(=O)N(c1ccccc1)C1(CCN(CCc2cccs2)CC1)C(=O)OC NHPPWKIWKNUHSS-UHFFFAOYSA-N 0.000 description 1
- UJYSYPVQHFNBML-UHFFFAOYSA-N methyl 5-aminolevulinate hydrochloride Chemical compound [Cl-].COC(=O)CCC(=O)C[NH3+] UJYSYPVQHFNBML-UHFFFAOYSA-N 0.000 description 1
- 125000006261 methyl amino sulfonyl group Chemical group [H]N(C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 description 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
- CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 1
- RSUWQAVSPOGTFD-UHFFFAOYSA-N n-(2,6-dimethyl-4-phenoxyphenyl)-2-(dipropylamino)acetamide Chemical compound C1=C(C)C(NC(=O)CN(CCC)CCC)=C(C)C=C1OC1=CC=CC=C1 RSUWQAVSPOGTFD-UHFFFAOYSA-N 0.000 description 1
- URLNYGJGKNTHOV-UHFFFAOYSA-N n-(2,6-dimethyl-4-phenoxyphenyl)-2-morpholin-4-ylacetamide Chemical compound C=1C(C)=C(NC(=O)CN2CCOCC2)C(C)=CC=1OC1=CC=CC=C1 URLNYGJGKNTHOV-UHFFFAOYSA-N 0.000 description 1
- CIPNTGGVKGDZDC-UHFFFAOYSA-N n-(2,6-dimethyl-4-phenoxyphenyl)-2-piperidin-1-ylacetamide Chemical compound C=1C(C)=C(NC(=O)CN2CCCCC2)C(C)=CC=1OC1=CC=CC=C1 CIPNTGGVKGDZDC-UHFFFAOYSA-N 0.000 description 1
- HPHGXJJNZJYZTG-UHFFFAOYSA-N n-(2,6-dimethyl-4-phenoxyphenyl)-2-pyrrolidin-1-ylacetamide Chemical compound C=1C(C)=C(NC(=O)CN2CCCC2)C(C)=CC=1OC1=CC=CC=C1 HPHGXJJNZJYZTG-UHFFFAOYSA-N 0.000 description 1
- XOHBSQBYIWTWOQ-UHFFFAOYSA-N n-(4-bromo-2,6-dimethylphenyl)-2-(dibutylamino)acetamide Chemical compound CCCCN(CCCC)CC(=O)NC1=C(C)C=C(Br)C=C1C XOHBSQBYIWTWOQ-UHFFFAOYSA-N 0.000 description 1
- YMEDJSMNCHSIMY-UHFFFAOYSA-N n-(4-bromo-2,6-dimethylphenyl)-2-(diethylamino)acetamide Chemical compound CCN(CC)CC(=O)NC1=C(C)C=C(Br)C=C1C YMEDJSMNCHSIMY-UHFFFAOYSA-N 0.000 description 1
- WKKFCBVEZXNVQR-UHFFFAOYSA-N n-(4-bromo-2,6-dimethylphenyl)-2-(dipropylamino)acetamide Chemical compound CCCN(CCC)CC(=O)NC1=C(C)C=C(Br)C=C1C WKKFCBVEZXNVQR-UHFFFAOYSA-N 0.000 description 1
- UFQBXPSKASHCKN-UHFFFAOYSA-N n-(4-bromo-2,6-dimethylphenyl)-2-morpholin-4-ylacetamide Chemical compound CC1=CC(Br)=CC(C)=C1NC(=O)CN1CCOCC1 UFQBXPSKASHCKN-UHFFFAOYSA-N 0.000 description 1
- UUVAZBRXGLBOCD-UHFFFAOYSA-N n-(4-bromo-2,6-dimethylphenyl)-2-piperidin-1-ylacetamide Chemical compound CC1=CC(Br)=CC(C)=C1NC(=O)CN1CCCCC1 UUVAZBRXGLBOCD-UHFFFAOYSA-N 0.000 description 1
- FTFZYOYKKMXBIZ-UHFFFAOYSA-N n-(4-bromo-2,6-dimethylphenyl)-2-pyrrolidin-1-ylacetamide Chemical compound CC1=CC(Br)=CC(C)=C1NC(=O)CN1CCCC1 FTFZYOYKKMXBIZ-UHFFFAOYSA-N 0.000 description 1
- VHXNDLUDRKRBCQ-KALLACGZSA-N n-[(3r,4s)-1-[2-(4-ethyl-5-oxotetrazol-1-yl)ethyl]-3-methylpiperidin-4-yl]-n-(2-fluorophenyl)-2-methoxyacetamide;hydrochloride Chemical compound Cl.O=C1N(CC)N=NN1CCN1C[C@@H](C)[C@@H](N(C(=O)COC)C=2C(=CC=CC=2)F)CC1 VHXNDLUDRKRBCQ-KALLACGZSA-N 0.000 description 1
- JPOSAFRGBMSBQS-UHFFFAOYSA-N n-[2,6-dimethyl-4-(2-phenylethoxy)phenyl]-2-(dipropylamino)acetamide Chemical compound C1=C(C)C(NC(=O)CN(CCC)CCC)=C(C)C=C1OCCC1=CC=CC=C1 JPOSAFRGBMSBQS-UHFFFAOYSA-N 0.000 description 1
- JCDCDKYKRZMSSO-UHFFFAOYSA-N n-[2,6-dimethyl-4-(2-phenylethoxy)phenyl]-2-morpholin-4-ylacetamide Chemical compound C=1C(C)=C(NC(=O)CN2CCOCC2)C(C)=CC=1OCCC1=CC=CC=C1 JCDCDKYKRZMSSO-UHFFFAOYSA-N 0.000 description 1
- YRNHLAIQOATMFE-UHFFFAOYSA-N n-[2,6-dimethyl-4-(2-phenylethoxy)phenyl]-2-piperidin-1-ylacetamide Chemical compound C=1C(C)=C(NC(=O)CN2CCCCC2)C(C)=CC=1OCCC1=CC=CC=C1 YRNHLAIQOATMFE-UHFFFAOYSA-N 0.000 description 1
- RJUPHOSGURUYLR-UHFFFAOYSA-N n-[2,6-dimethyl-4-(2-phenylethoxy)phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C=1C(C)=C(NC(=O)CN2CCCC2)C(C)=CC=1OCCC1=CC=CC=C1 RJUPHOSGURUYLR-UHFFFAOYSA-N 0.000 description 1
- 125000006095 n-butyl sulfinyl group Chemical group 0.000 description 1
- 125000006126 n-butyl sulfonyl group Chemical group 0.000 description 1
- 125000001298 n-hexoxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000006093 n-propyl sulfinyl group Chemical group 0.000 description 1
- 125000006124 n-propyl sulfonyl group Chemical group 0.000 description 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 description 1
- 239000005645 nematicide Substances 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005246 nonafluorobutyl group Chemical group FC(F)(F)C(F)(F)C(F)(F)C(F)(F)* 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- LUKSBMJXPCFBKO-UHFFFAOYSA-N prodilidine Chemical compound C=1C=CC=CC=1C1(OC(=O)CC)CCN(C)C1C LUKSBMJXPCFBKO-UHFFFAOYSA-N 0.000 description 1
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- KMGJRCNLDZGSFX-UHFFFAOYSA-M sodium;3-aminopropane-1-sulfonate Chemical compound [Na+].NCCCS([O-])(=O)=O KMGJRCNLDZGSFX-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- UNCRKEZQEKKGQX-UHFFFAOYSA-N trans-aconitic acid anhydride Chemical compound OC(=O)C1=CC(=O)OC(=O)C1 UNCRKEZQEKKGQX-UHFFFAOYSA-N 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 description 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A—HUMAN NECESSITIES
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- A—HUMAN NECESSITIES
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
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- A—HUMAN NECESSITIES
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- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
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- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/707—1,2,3- or 1,2,4-triazines; Hydrogenated 1,2,3- or 1,2,4-triazines
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
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- A—HUMAN NECESSITIES
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- A—HUMAN NECESSITIES
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- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
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- A—HUMAN NECESSITIES
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- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
- A01N47/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing >N—S—C≡(Hal)3 groups
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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Abstract
Description
技术领域
本发明涉及一种新的吡唑衍生物或其农业上可接受的盐,以及含有该衍生物作为活性成分的有害生物防治剂。
背景技术
专利文献1中虽然记载了一种具有有害生物防治效果的吡唑衍生物,但是未具体揭示在吡唑环的3位具有羧酸酰胺的化合物。
非专利文献1中虽然记载了一种苯基在吡唑环的4位进行取代的吡唑衍生物,但是未记载其有害生物防治活性。
[专利文献1]WO 2012/102387 A
[非专利文献1]International Journal of Chem Tech Research,2013,第5卷,第1期,第80-84页
发明内容
发明所要解决的课题
针对有用作物所使用的有害生物防治剂需要为这样的药剂,当施用于土壤或茎叶时能够以低药量呈现充分的有害生物防治效果。此外,对化学物质的安全性、环境影响的要求日益提高,而期望开发更安全的有害生物防治剂。而且,近年来,由于常年使用杀虫剂或杀螨剂等的有害生物防治剂,而出现对该有害生物防治剂具有抵抗性的有害生物,因此,难以完全地防治有害生物。此外,对人畜毒性高的有害生物防治剂的使用在对于操作者的安全性等方面也会存在问题。
鉴于上述情况,本发明的目的是解决常规的有害生物防治剂所面临的问题,并进一步提供一种在安全性、防治效果、残效性等方面均表现优异的有害生物防治剂。
解决课题的手段
为了开发如上所述具有期望特性的有害生物防治剂,本发明人合成了多种吡唑衍生物,并认真地研究了这些吡唑衍生物的生理活性。作为结果,本发明人发现由以下通式[I]表示的吡唑衍生物(以下称为本发明化合物)对各种有害生物显示出优异的效力,经过进一步继续研究,最终完成了本发明。
即,本发明的主题具有以下特征。
(1)一种由通式[I]表示的吡唑衍生物或其农业学上可接受的盐,
[化学式1]
式中,
p表示0或1的整数,
R1、R2、R3、R4和R5分别独立地表示氢原子、卤素原子、C1–C6烷基、羟基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基、C3–C6环烷基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、氰基或硝基,
A表示氧原子或硫原子,
Q表示卤素原子、或未取代的或经(R8)m取代的C6–C10芳基或是未取代的或经(R8)m取代的杂芳基,
R6和R7分别独立地表示氢原子、C1–C6烷基、C3–C6环烷基、C3–C6环烷基C1–C6烷基、C2–C7炔基、C2–C6烯基、羟基、C1–C6烷氧基、C1–C6烷氧基C1–C6烷基、C1–C6卤代烷基、2-四氢呋喃基、3-四氢呋喃基、2-四氢吡喃基、4-四氢吡喃基、氰基C1–C6烷基、氰基C3–C6环烷基、羟基C1–C6烷基、甲酰基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、C1–C6烷基羰基、C1–C6烷氧基C1–C6烷基羰基、C3–C6环烷基羰基、C3–C6环烷基C1–C6烷基羰基、C1–C6烷氧基羰基、氨甲酰基、单(C1–C6烷基)氨基羰基、二(C1–C6烷基)氨基羰基、未取代的或经(R9)n取代的苯基羰基、未取代的或经(R9)n取代的C7–C13芳烷基羰基、未取代的或经(R9)n取代的吡啶基羰基、未取代的或经(R9)n取代的吡唑基羰基、吡啶-2-基甲基、吡啶-3-基甲基、(C1–C6烷基)硫代羰基、(C1–C6烷氧基)硫代羰基、硫代氨甲酰基、单(C1–C6烷基)氨基硫代羰基、二(C1–C6烷基)氨基硫代羰基、C1–C6烷基磺酰基、氨磺酰基、单(C1–C6烷基)氨基磺酰基、二(C1–C6烷基)氨基磺酰基、R10R11N-C1–C6烷基、C1–C6烷氧基羰基C1–C6烷基、氨基羰基C1–C6烷基、单(C1–C6烷基)氨基羰基C1–C6烷基、单(C3–C6环烷基)氨基羰基C1–C6烷基、单(C1–C6卤代烷基)氨基羰基C1–C6烷基、二(C1–C6烷基)氨基羰基C1–C6烷基、肟基、C1–C6烷氧基亚氨基、肟基C1–C6烷基、或C1–C6烷氧基亚氨基C1–C6烷基,R6和R7可以一起形成=CR12N(R13)R14或=CR12OR15,此外,R6和R7可以与它们所键合的碳原子一起形成3至6元碳环、或具有1至4个选自氧原子、硫原子和氮原子的杂原子的3至6元杂环,该杂环可由卤素原子、氰基、硝基、C1–C6烷基、C1–C6烷氧基、C1–C6卤代烷基或氧代基团所取代,
R8表示氢原子、卤素原子、羟基、硫醇基、C1–C6烷基、C1–C6卤代烷基、C3–C6环烷基、C3–C6环烷基C1–C6烷基、C3–C6环烷基C2–C6炔基、C3–C6卤代环烷基、C3–C6卤代环烷基C1–C6烷基、C2–C6烯基、C2–C6卤代烯基、C2–C7炔基、C2–C6卤代炔基、C1–C6烷氧基、C1–C6卤代烷氧基、C3–C6环烷氧基、环氧乙烷-2-基、单(环氧乙烷-2-基)C1–C3烷基、C3–C6卤代环烷氧基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、C3–C6环烷基硫基、C3–C6环烷基亚磺酰基、C3–C6环烷基磺酰基、C1–C6卤代烷基硫基、C1–C6卤代烷基亚磺酰基、C1–C6卤代烷基磺酰基、甲酰基、C1–C6烷基羰基、C1–C6卤代烷基羰基、C1–C6烷氧基羰基、氨基羰基、单(C1–C6烷基)氨基羰基、二(C1–C6烷基)氨基羰基、氨基C1–C6烷基、单(C1–C6烷基)氨基C1–C6烷基、二(C1–C6烷基)氨基C1–C6烷基、三(C1–C6烷基)甲硅烷基氧基C1–C6烷基、C1–C6烷基羰基C1–C6烷基、C1–C6烷基羰基氧基C1–C6烷基、C1–C6卤代烷基羰基C1–C6烷基、C1–C6烷氧基羰基C1–C6烷基、羟基C1–C6烷基、C1–C6烷氧基C1–C6烷基、C1–C6卤代烷氧基C1–C6烷基、C1–C6烷氧基C1–C6卤代烷基、C1–C6卤代烷氧基C1–C6卤代烷基、甲酰氧基、C1–C6烷基羰基氧基、C1–C6卤代烷基羰基氧基、氨基羰基氧基、单(C1–C6烷基)氨基羰基氧基、二(C1–C6烷基)氨基羰基氧基、氨基羰基氧基C1–C6烷基、单(C1–C6烷基)氨基羰基氧基C1–C6烷基、二(C1–C6烷基)氨基羰基氧基C1–C6烷基、C1–C6烷氧基羰基氧基、C1–C6烷氧基羰基氧基C1–C6烷基、C1–C6烷基磺酰基氧基、C1–C6卤代烷基磺酰基氧基、C1–C6烷硫基C1–C6烷基、C1–C6烷基亚磺酰基C1–C6烷基、C1–C6烷基磺酰基C1–C6烷基、C1–C6卤代烷硫基C1–C6烷基、C1–C6卤代烷基亚磺酰基C1–C6烷基、C1–C6卤代烷基磺酰基C1–C6烷基、C3–C6环烷基C1–C6烷氧基、C3–C6卤代环烷基C1–C6烷氧基、C3–C6环烷基C1–C6烷硫基、C3–C6环烷基C1–C6烷基亚磺酰基、C3–C6环烷基C1–C6烷基磺酰基、C3–C6卤代环烷基C1–C6烷硫基、C3–C6卤代环烷基C1–C6烷基亚磺酰基、C3–C6卤代环烷基C1–C6烷基磺酰基、未取代的或经(R9)n取代的苯基、未取代的或经(R9)n取代的吡唑-1-基、未取代的或经(R9)n取代的吡啶-2-基、未取代的或经(R9)n取代的嘧啶-2-基、未取代的或经(R9)n取代的吡嗪-2-基、未取代的或经(R9)n取代的1,3,5-三嗪-2-基、未取代的或经(R9)n取代的1,2,4-三嗪-3-基、未取代的或经(R9)n取代的1,2,4三嗪-5-基、未取代的或经(R9)n取代的1,2,4-三嗪-6-基、未取代的或经(R9)n取代的苯氧基、未取代的或经(R9)n取代的苄基、未取代的或经(R9)n取代的苄氧基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、羧基、1,3-二氧戊环-2-基、1,3-二烷-2-基、未取代的或经(R9)n取代的1H-咪唑-2-基、未取代的或经(R9)n取代的噻唑-2-基、未取代的或经(R9)n取代的唑-2-基、(肟基)甲基、(甲基氧基亚氨基)甲基、未取代的或经(R9)n取代的异唑-3-基、未取代的或经(R9)n取代的4,5-二氢-3-异唑基、氰基或硝基,并且进一步地,相邻的两个R8可以与各R8所键合的碳原子一起形成4至8元碳环或具有1至4个选自氧原子、硫原子及氮原子的杂原子的4至8元杂环,此时所形成的碳环或杂环可由选自卤素原子、氰基、硝基、C1–C6烷基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基或氧代基团中的一个或多个化学上可接受的取代基所取代,
R9表示卤素原子、C1–C6烷基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、C1–C6卤代烷基硫基、C1–C6卤代烷基亚磺酰基、C1–C6卤代烷基磺酰基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、氰基或硝基,
R10和R11分别独立地表示氢原子、C1–C6烷基、C1–C6卤代烷基或C3–C6环烷基,并且进一步地,R10和R11可以与它们所键合的碳原子一起形成3至6元环,
R12表示氢原子、C1–C6烷基或C3–C6环烷基,
R13和R14分别独立地表示氢原子、C1–C6烷基、C1–C6卤代烷基、C3–C6环烷基或C1–C6烷氧基,并且进一步地,R13和R14可以与它们所键合的碳原子一起形成3至6元碳环、或具有1至4个选自氧原子、硫原子和氮原子的杂原子的3至6元杂环,
R15表示C1–C6烷基,
m表示化学上可接受的R8的数目,并且为0到7的整数,当m为2以上时,R8可以彼此相同或不同,
n表示化学上可接受的R9的数目,并且是0至5的整数,并且当n为2以上时,R9可以彼此相同或不同。
(2)一种由通式[II]表示的吡唑衍生物或其农业学上可接受的盐,
[化学式2]
其中,
p表示0或1的整数,
R1、R2、R3、R4和R5分别独立地表示氢原子、卤素原子、C1–C6烷基、羟基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基、C3–C6环烷基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、氰基或硝基,
R16表示氢原子或C1–C6烷基,
Q'表示卤素原子、C1–C6烷基磺酰基氧基、C1–C6卤代烷基磺酰基氧基、二(C1–C6烷基)氨磺酰氧基、未取代的或经(R9)n取代的苯基磺酰基氧基、未取代的或经(R8)m取代的C6–C10芳基、或未取代的或经(R8)m取代的杂芳基,
R8表示氢原子、卤素原子、羟基、硫醇基、C1–C6烷基、C1–C6卤代烷基、C3–C6环烷基、C3–C6环烷基C1–C6烷基、C3–C6环烷基C2–C6炔基、C3–C6卤代环烷基、C3–C6卤代环烷基C1–C6烷基、C2–C6烯基、C2–C6卤代烯基、C2–C7炔基、C2–C6卤代炔基、C1–C6烷氧基、C1–C6卤代烷氧基、C3–C6环烷氧基、环氧乙烷-2-基、单(环氧乙烷-2-基)C1–C3烷基、C3–C6卤代环烷氧基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、C3–C6环烷硫基、C3–C6环烷基亚磺酰基、C3–C6环烷基磺酰基、C1–C6卤代烷硫基、C1–C6卤代烷基亚磺酰基、C1–C6卤代烷基磺酰基、甲酰基、C1–C6烷基羰基、C1–C6卤代烷基羰基、C1–C6烷氧基羰基、氨基羰基、单(C1–C6烷基)氨基羰基、二(C1–C6烷基)氨基羰基、氨基C1–C6烷基、单(C1–C6烷基)氨基C1–C6烷基、二(C1–C6烷基)氨基C1–C6烷基、三(C1–C6烷基)甲硅烷基氧基C1–C6烷基、C1–C6烷基羰基C1–C6烷基、C1–C6烷基羰基氧基C1–C6烷基、C1–C6卤代烷基羰基C1–C6烷基、C1–C6烷氧基羰基C1–C6烷基、羟基C1–C6烷基、C1–C6烷氧基C1–C6烷基、C1–C6卤代烷氧基C1–C6烷基、C1–C6烷氧基C1–C6卤代烷基、C1–C6卤代烷氧基C1–C6卤代烷基、甲酰氧基、C1–C6烷基羰基氧基、C1–C6卤代烷基羰基氧基、氨基羰基氧基、单(C1–C6烷基)氨基羰基氧基、二(C1–C6烷基)氨基羰基氧基、氨基羰基氧基C1–C6烷基、单(C1–C6烷基)氨基羰基氧基C1–C6烷基、二(C1–C6烷基)氨基羰基氧基C1–C6烷基、C1–C6烷氧基羰基氧基、C1–C6烷氧基羰基氧基C1–C6烷基、C1–C6烷基磺酰基氧基、C1–C6卤代烷基磺酰基氧基、C1–C6烷硫基C1–C6烷基、C1–C6烷基亚磺酰基C1–C6烷基、C1–C6烷基磺酰基C1–C6烷基、C1–C6卤代烷硫基C1–C6烷基、C1–C6卤代烷基亚磺酰基C1–C6烷基、C1–C6卤代烷基磺酰基C1–C6烷基、C3–C6环烷基C1–C6烷氧基、C3–C6卤代环烷基C1–C6烷氧基、C3–C6环烷基C1–C6烷硫基、C3–C6环烷基C1–C6烷基亚磺酰基、C3–C6环烷基C1–C6烷基磺酰基、C3–C6卤代环烷基C1–C6烷硫基、C3–C6卤代环烷基C1–C6烷基亚磺酰基、C3–C6卤代环烷基C1–C6烷基磺酰基、未取代的或经(R9)n取代的苯基、未取代的或经(R9)n取代的吡唑-1-基、未取代的或经(R9)n取代的吡啶-2-基、未取代的或经(R9)n取代的嘧啶-2-基、未取代的或经(R9)n取代的吡嗪-2-基、未取代的或经(R9)n取代的1,3,5-三嗪-2-基、未取代的或经(R9)n取代的1,2,4-三嗪-3-基、未取代的或经(R9)n取代的1,2,4三嗪-5-基、未取代的或经(R9)n取代的1,2,4-三嗪-6-基、未取代的或经(R9)n取代的苯氧基、未取代的或经(R9)n取代的苄基、未取代的或经(R9)n取代的苄氧基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、羧基、1,3-二氧戊环-2-基、1,3-二烷-2-基、未取代的或经(R9)n取代的1H-咪唑-2-基、未取代的或经(R9)n取代的噻唑-2-基、未取代的或经(R9)n取代的唑-2-基、(肟基)甲基、(甲基氧基亚氨基)甲基、未取代的或经(R9)n取代的异唑-3-基、未取代的或经(R9)n取代的4,5-二氢-3-异唑基、氰基或硝基,并且进一步地,相邻的两个R8可以与各R8所键合的碳原子一起形成4至8元碳环或具有1至4个选自氧原子、硫原子及氮原子的杂原子的4至8元杂环,此时所形成的碳环或杂环可由选自卤素原子、氰基、硝基、C1–C6烷基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基或氧代基团中的一个或多个化学上可接受的取代基所取代,
R9表示卤素原子、C1–C6烷基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、C1–C6卤代烷硫基、C1–C6卤代烷基亚磺酰基、C1–C6卤代烷基磺酰基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、氰基或硝基,
m表示化学上可接受的R8的数目,并且为0到7的整数,当m为2以上时,R8可以彼此相同或不同,
n表示化学上可接受的R9的数目,并且是0至5的整数,并且当n为2以上时,R9可以彼此相同或不同。
(3)一种农药组合物,其包含根据(1)或(2)所述的吡唑衍生物或其农业上可接受的盐作为活性成分。
(4)根据(3)所述的农药组合物,其中,该农药组合物进一步包含表面活性剂。
(5)一种有害生物防治剂,其包含根据(1)或(2)所述的吡唑衍生物或其农业上可接受的盐作为活性成分。
(6)根据(5)所述的有害生物防治剂,其为杀虫剂。
(7)根据(5)所述的有害生物防治剂,其对栽培农艺或园艺用植物的旱地或水田中的有害生物具有防治效力。
(8)根据(7)所述的有害生物防治剂,其中,所述农艺或园艺用植物为利用育种法或基因重组技术而被赋予了耐性的植物。
(9)一种有害生物的防治方法,其中使用有效成分量的根据的(1)或(2)所述的吡唑衍生物或其农业上可接受的盐。
(10)一种有害生物的防治方法,其中,将包含根据(1)或(2)所述的吡唑衍生物或其农业上可接受的盐作为活性成分的农药组合物同时或分批地作用于农艺或园艺用作物或将要培育或正在培育农艺或园艺用作物的场所。
(11)根据(9)或(10)所述的有害生物的防治方法,其中,施用有害生物防治剂的场所为水田、旱地、草地、果树园、非农耕地、温室、育苗设施或植物工厂。
(12)根据(9)至(11)中任一项所述的有害生物的防治方法,其中将吡唑衍生物或其农业上可接受的盐用作杀虫剂。
(13)一种有害生物防治剂的使用方法,其中,将根据(5)至(8)中任一项所述的有害生物防治剂用于防治对农艺或园艺用作物有害的生物。
发明的效果
含有本发明化合物的有害生物防治剂对包括半翅目(Hemiptera)害虫、鳞翅目(Lepidoptera)害虫、鞘翅目(Coleoptera)害虫、双翅目(Diptera)害虫、膜翅目(Hymenoptera)害虫、直翅目(Orthoptera)害虫、等翅目(Isoptera)害虫、缨翅目(Thysanoptera)害虫、蜱螨目(Acarina)害虫和植物寄生性线虫类在内的广范围的有害生物呈现优异的防治效果,并且能够防治取得了抗药性的有害生物。
具体实施方式
以下将对本说明书所使用的记号以及术语进行说明。
在本发明中,“有害生物防治剂”是指农园艺领域、家畜和宠物等的动物、家庭用或防疫用的杀虫剂、杀螨剂、杀线虫剂等。
在本发明中,“卤素原子”表示氟原子、氯原子、溴原子或碘原子。
在本发明中,若无特别限定,“C6–C10芳基”是指具有6至10个碳原子的芳香族烃基,C6–C10芳基的实例包括:苯基、萘-1-基或萘-2-基。
在本发明中,若无特别限定,“杂芳基”是指芳香族杂环或稠合杂环基,并且杂芳基的实例包括:吡咯基、呋喃基、噻吩基、吡唑基、唑基、异唑基、咪唑基、1,2,4-二唑基、1,2,3-二唑基、1,3,4-二唑基、1,2,4-三唑基、1,2,3-三唑基、噻唑基、异噻唑基、1,2,4-噻二唑基、1,2,3-噻二唑基、1,3,4-噻二唑基、吡啶基、嘧啶基、吡嗪基、哒嗪基、1,3,5-三嗪基、1,2,4-三嗪基、苯并呋喃基、苯并噻吩基、吲哚基、苯并唑基、苯并咪唑基、苯并三唑基、苯并噻唑基、喹啉基、喹唑啉基、喹喔啉基、酞嗪基或萘啶基。
在本发明中,若无特别限定,“C1–C3烷基”是指具有1至3个碳原子的直链或支链烷基,C1–C3烷基的实例包括:甲基、乙基、正丙基或异丙基。
在本发明中,若无特别限定,“C1–C6烷基”是指具有1至6个碳原子的直链或支链烷基,除了上述“C1–C3烷基”中的实例以外,C1–C6烷基的实例包括:正丁基、仲丁基(s-butyl)、异丁基、叔丁基、正戊基、1-甲基丁基、2-甲基丁基、3-甲基丁基、1-乙基丙基、1,1-二甲基丙基、1,2-二甲基丙基、新戊基、正己基、1-甲基戊基、2-甲基戊基、3-甲基戊基、4-甲基戊基、1-乙基丁基、2-乙基丁基、1,1-二甲基丁基、1,2-二甲基丁基、1,3-二甲基丁基、2,2-二甲基丁基、2,3-二甲基丁基、3,3-二甲基丁基、1,1,2-三甲基丙基、1,2,2-三甲基丙基、1-乙基-1-甲基丙基或1-乙基-2-甲基丙基。
在本发明中,若无特别限定,“C1–C6卤代烷基”是指被相同或不同的1至13个卤素原子所取代的具有1至6个碳原子的直链或支链烷基,例如表示卤代烷基,并且C1–C6卤代烷基的实例包括:氟甲基、二氟甲基、三氟甲基、氯甲基、二氯甲基、三氯甲基、溴甲基、二溴甲基、三溴甲基、碘甲基、氯二氟甲基、二氯氟甲基、1-氟乙基、2-氟乙基、1,1-二氟乙基、2,2-二氟乙基、2,2,2-三氟乙基、1,1,2,2-四氟乙基、五氟乙基、1-氯乙基、2-氯乙基、1,1-二氯乙基、2,2-二氯乙基、2,2,2-三氯乙基、1,1,2,2-四氯乙基、五氯乙基、1-溴乙基、2-溴乙基、2,2,2-三溴乙基、1-碘乙基、2-碘乙基、2-氯-2,2-二氟乙基、2,2-二氯-2-氟乙基、1-氟丙基、2-氟丙基、3-氟丙基、1,1-二氟丙基、2,2-二氟丙基、3,3-二氟丙基、3,3,3-三氟丙基、2,2,3,3,3-五氟丙基、1,1,2,3,3,3-六氟丙基、七氟丙基、1-氟丙烷-2-基、2-氟丙烷-2-基、1,1-二氟丙烷-2-基、1,2-二氟丙烷-2-基、1,3-二氟丙烷-2-基、1,2,3-三氟丙烷-2-基、1,1,3,3-四氟丙烷-2-基、1,1,1,3,3,3-六氟丙烷-2-基、七氟丙烷-2-基、1-氯丙基、2-氯丙基、3-氯丙基、1,1-二氯丙基、2,2-二氯丙基、3,3-二氯丙基、3,3,3-三氯丙基、2,2,3,3,3-五氯丙基、七氯丙基、1-氯丙烷-2-基、2-氯丙烷-2-基、1,1-二氯丙烷-2-基、1,2-二氯丙烷-2-基、1,3-二氯丙烷-2-基、1,2,3-三氯丙烷-2-基、1,1,3,3-四氯丙烷-2-基、1,1,1,3,3,3-六氯丙烷-2-基、七氯丙烷-2-基、1-溴丙基、2-溴丙基、3-溴丙基、1-溴丙烷-2-基、2-溴丙烷-2-基、1-碘丙基、2-碘丙基、3-碘丙基、1-碘丙烷-2-基、2-碘丙烷-2-基、1-氟丁基、2-氟丁基、3-氟丁基、4-氟丁基、4,4-二氟丁基、4,4,4-三氟丁基、3,3,4,4,4-五氟丁基、2,2,3,3,4,4,4-七氟丁基、九氟丁基、1,1,1-三氟丁烷-2-基、4,4,4-三氟丁烷-2-基、3,3,4,4,4-五氟丁烷-2-基、九氟丁烷-2-基、1,1,1,3,3,3-六氟-2-(三氟甲基)丙烷-2-基、2,2,3,4,4,4-六氟丁基、1-氯丁基、2-氯丁基、3-氯丁基、4-氯丁基、4,4-二氯丁基、4,4,4-三氯丁基、九氯丁基、1,1,1-三氯丁烷-2-基、4,4,4-三氯丁烷-2-基、九氯丁烷-2-基、1-溴丁基、2-溴丁基、3-溴丁基、4-溴丁基、1-碘丁基、2-碘丁基、3-碘丁基、4-碘丁基、4-氯-1,1,2,2,3,3,4,4-八氟丁基、4-溴-1,1,2,2,3,3,4,4-八氟丁基、1-氟戊基、2-氟戊基、3-氟戊基、4-氟戊基、5-氟戊基、5,5,5-三氟戊基、4,4,5,5,5-五氟戊基、3,3,4,4,5,5,5-七氟戊基、2,2,3,3,4,4,5,5-八氟戊基、2,2,3,3,4,4,5,5,5-九氟戊基、十一氟戊基、4,4,4-三氟-3-甲基丁基、1-氯戊基、2-氯戊基、3-氯戊基、4-氯戊基、5-氯戊基、5,5,5-三氯戊基、4,4,5,5,5-五氯戊基、3,3,4,4,5,5,5-七氯戊基、2,2,3,3,4,4,5,5,5-九氯戊基、十一氯戊基、1-溴戊基、2-溴戊基、3-溴戊基、4-溴戊基、5-溴戊基、5-碘戊基、1-氟己基、2-氟己基、3-氟己基、4-氟己基、5-氟己基、6-氟己基、6,6,6-三氟己基、5,5,6,6,6-五氟己基、4,4,5,5,6,6,6-七氟己基、3,3,4,4,5,5,6,6,6-九氟己基、2,2,3,3,4,4,5,5,6,6-十氟己基、2,2,3,3,4,4,5,5,6,6,6-十一氟己基、十三氟己基、1-氯己基、2-氯己基、3-氯己基、4-氯己基、5-氯己基、6-氯己基、5-溴己基、6-溴己基、5-碘己基或6-碘己基。
在本发明中,若无特别限定,“C1–C6烷氧基”是指烷基部分为如上所定义的(C1–C6烷基)-O-基,C1–C6烷氧基的实例包括:甲氧基、乙氧基、正丙氧基、异丙氧基、正丁氧基、异丁氧基、仲丁氧基、叔丁氧基、正戊氧基、1-甲基丁氧基、2-甲基丁氧基、3-甲基丁氧基、1-乙基丙氧基、1,1-二甲基丙氧基、1,2-二甲基丙氧基或正己氧基。
在本发明中,若无特别限定,“C1–C6卤代烷氧基”是指卤代烷基部分为如上所定义的(C1–C6卤代烷基)-O-基,C1–C6卤代烷氧基的实例包括:二氟甲氧基、二氯甲氧基、三氟甲氧基、三氯甲氧基、三溴甲氧基、氯二氟甲氧基、溴二氟甲氧基、2-氟乙氧基、1-氯乙氧基、2-氯乙氧基、1-溴乙氧基、2-溴乙氧基、2,2-二氟乙氧基、1,2-二氯乙氧基、2,2-二氯乙氧基、2,2,2-三氟乙氧基、2,2,2-三氯乙氧基、1,1,2,2-四氟乙氧基、五氟乙氧基、2-溴-2-氯乙氧基、2-氯-1,1,2,2-四氟乙氧基、1-氯-1,2,2,2-四氟乙氧基、1-氯丙氧基、2-氯丙氧基、3-氯丙氧基、2-溴丙氧基、3-溴丙氧基、2-溴-1-甲基乙氧基、3-碘丙氧基、2,3-二氯丙氧基、2,3-二溴丙氧基、3,3,3-三氟丙氧基、3,3,3-三氟-2-丙氧基、3,3,3-三氯丙氧基、3-溴-3,3-二氟丙氧基、2,2-二氟丙氧基、3,3-二氯-3-氟丙氧基、2,2,3,3-四氟丙氧基、1-溴-3,3,3-三氟丙氧基、2,2,3,3,3-五氟丙氧基、2,2,2-三氟-1-三氟甲基乙氧基、七氟丙氧基、七氟-2-丙氧基、1,2,2,2-四氟-1-三氟甲基乙氧基、1,1,2,3,3,3-六氟丙氧基、2-氯丁氧基、3-氯丁氧基、4-氯丁氧基、2-氯-1,1-二甲基乙氧基、4-溴丁氧基、3-溴-2-甲基丙氧基、2-溴-1,1-二甲基乙氧基、2,2-二氯-1,1-二甲基乙氧基、2-氯-1-氯甲基-2-甲基乙氧基、4,4,4-三氟丁氧基、3,3,3-三氟-1-甲基丙氧基、3,3,3-三氟-2-甲基丙氧基、2,3,4-三氯丁氧基、2,2,2-三氯-1,1-二甲基乙氧基、4-氯-4,4-二氟丁氧基、4,4-二氯-4-氟丁氧基、4-溴-4,4-二氟丁氧基、2,4-二溴-4,4-二氟丁氧基、3,4-二氯-3,4,4-三氟丁氧基、3,3-二氯-4,4,4-三氟丁氧基、4-溴-3,3,4,4-四氟丁氧基、4-溴-3-氯-3,4,4-三氟丁氧基、2,2,3,3,4,4-六氟丁氧基、2,2,3,4,4,4-六氟丁氧基、2,2,2-三氟-1-甲基-1-三氟甲基乙氧基、3,3,3-三氟-2-三氟甲基丙氧基、2,2,3,3,4,4,4-七氟丁氧基、3,3,4,4,4-五氟-2-丁氧基、2,3,3,3-四氟-2-三氟甲基丙氧基、1,1,2,2,3,3,4,4-八氟丁氧基、九氟丁氧基、全氟-叔丁氧基、4-氯-1,1,2,2,3,3,4,4-八氟丁氧基、5,5,5-三氟戊氧基、4,4,5,5,5-五氟戊氧基、3,3,4,4,5,5,5-七氟戊氧基、3,3,4,4,5,5,5-七氟-2-戊氧基、2,2,3,3,4,4,5,5,5-九氟戊氧基、2,2,3,3,4,4,5,5-八氟戊氧基、全氟戊氧基、4,4,5,5,5-五氟-2-丁氧基、2,2-双(三氟甲基)丙氧基、2,2,3,3,4,4,5,5,6,6,6-十一氟己氧基、3,3,4,4,5,5,6,6,6-九氟己氧基、4,4,5,5,6,6,6-七氟己氧基、2,2,3,3,4,4,5,5,6,6-十氟己氧基、4,4,4-三氟-3,3-双(三氟甲基)丁氧基或全氟己氧基。
在本发明中,若无特别限定,“C3–C6环烷基”是指具有3至6个碳原子的环烷基,C3–C6环烷基的实例包括:环丙基、环丁基、环戊基或环己基。
在本发明中,若无特别限定,“C3–C6卤代环烷基”是指被相同或不同的1至11个卤素原子所取代的具有3至6个碳原子的环烷基,C3–C6卤代环烷基的实例包括:1-氟环丙基、2-氟环丙基、2,2-二氟环丙基、2,2,3,3-四氟环丙基、1-氯环丙基、2-氯环丙基、2,2-二氯环丙基、2,2,3,3-四氯环丙基、2,2-二溴环丙基、2,2二碘环丙基、1-氟环丁基、2-氟环丁基、3-氟环丁基、3,3-二氟环丁基、七氟环丁基、2-氯环丁基、3-氯环丁基、3,3-二氯环丁基、3,3-二溴环丁基、3,3-二碘环丁基、1-氟环戊基、2-氟环戊基、3-氟环戊基、2,2-二氟环戊基、3,3-二氟环戊基、九氟环戊基、2,2-二氯环戊基、3,3-二氯环戊基、2,2-二溴环戊基、3,3-二溴环戊基、2,2-二碘环戊基、3,3-二碘环戊基、1-氟环己基、2-氟环己基、3-氟环己基、4-氟环己基、2,2-二氟环己基、3,3-二氟环己基、4,4二氟环己基、1-氯环己基、2-氯环己基、3-氯环己基、4-氯环己基、2,2-二氯环己基、3,3-二氯环己基、4,4-二氯环己基、3,3-二溴环己基、4,4-二溴环己基、3,3-二碘环己基或4,4-二碘环己基。
在本发明中,若无特别限定,“C3–C6环烷基C1–C6烷基”是指环烷基部分以及烷基部分为如上所定义的(C3–C6环烷基)-(C1–C6烷基)-基,C3–C6环烷基C1–C6烷基的实例包括:环丙基甲基、环丁基甲基、环戊基甲基、2-环丙基乙基、2-环丁基乙基或2-环戊基乙基。
在本发明中,若无特别限定,“C3–C6卤代环烷基C1–C6烷基”是指卤代环烷基部分以及烷基部分为如上所定义的(C3–C6卤代环烷基)-(C1–C6烷基)-基,C3–C6卤代环烷基C1–C6烷基的实例包括:(1-氟环丙基)甲基、(2-氟环丙基)甲基、(2,2-二氟环丙基)甲基、(1-氯环丙基)甲基、(2-氯环丙基)甲基或(2,2-二氯环丙基)甲基。
在本发明中,“C1–C6烷氧基C1–C6烷基”是指烷氧基部分为如上所定义的(C1–C6烷氧基)-(C1–C6烷基)-基,C1–C6烷氧基C1–C6烷基的实例包括:甲氧基甲基、1-甲氧基乙基、2-甲氧基乙基、2-乙氧基乙基、3-乙氧基丙基、3-甲氧基丙基、1-甲基-3-甲氧基丁基或3-丁氧基丁基。
在本发明中,“C1–C6烷氧基C1–C6卤代烷基”是指烷氧基部分为如上所定义的(C1–C6烷氧基)-(C1–C6卤代烷基)-基,C1–C6烷氧基C1–C6卤代烷基的实例包括:2-甲氧基-1,1,2-三氟乙基或2-乙氧基-1,1,2-三氟乙基。
在本发明中,“C1–C6卤代烷氧基C1–C6烷基”是指卤代烷氧基部分为如上所定义的(C1–C6卤代烷氧基)-(C1–C6烷基)-基,C1–C6卤代烷氧基C1–C6烷基的实例包括:2-(二氟甲氧基)乙基、2-(三氟甲氧基)乙基、2-(2,2-二氟乙氧基)乙基或2-(2,2,2-三氟乙氧基)乙基。
在本发明中,“C1-C6卤代烷氧基C1-C6卤代烷基”是指卤代烷氧基部分为如上所定义的(C1-C6卤代烷氧基)-(C1-C6卤代烷基)-基,C1-C6卤代烷氧基C1-C6卤代烷基的实例包括:1,1,2-三氟-2-(三氟甲氧基)乙基、1,1,2-三氟-2-(五氟乙氧基)乙基或1,1,2-三氟-2-(七氟丙氧基)乙基。
在本发明中,若无特别限定,“C2-C6烯基”是指具有2至6个碳原子的直链或支链烯基,C2-C6烯基的实例包括:乙烯基、1-丙烯基、异丙烯基、2-丙烯基、1-丁烯基、1-甲基-1-丙烯基、2-丁烯基、1-甲基-2-丙烯基、3-丁烯基、2-甲基-1-丙烯基、2-甲基-2-丙烯基、1,3-丁二烯基、1-戊烯基、1-乙基-2-丙烯基、2-戊烯基、1-甲基-1-丁烯基、3-戊烯基、1-甲基-2-丁烯基、4-戊烯基、1-甲基-3-丁烯基、3-甲基-1-丁烯基、1,2-二甲基-2-丙烯基、1,1-二甲基-2-丙烯基、2-甲基-2-丁烯基、3-甲基-2-丁烯基、1,2-二甲基-1-丙烯基、2-甲基-3-丁烯基、3-甲基-3-丁烯基、1,3-戊二烯基、1-乙烯基-2-丙烯基、1-己烯基、1-丙基-2-丙烯基、2-己烯基、1-甲基-1-戊烯基、1-乙基-2-丁烯基、3-己烯基、4-己烯基、5-己烯基、1-甲基-4-戊烯基、1-乙基-3-丁烯基、1-(异丁基)乙烯基、1-乙基-1-甲基-2-丙烯基、1-乙基-2-甲基-2-丙烯基、1-(异丙基)-2-丙烯基、2-甲基-2-戊烯基、3-甲基-3-戊烯基、4-甲基-3-戊烯基、1,3-二甲基-2-丁烯基、1,1-二甲基-3-丁烯基、3-甲基-4-戊烯基、4-甲基-4-戊烯基、1,2-二甲基-3-丁烯基、1,3-二甲基-3-丁烯基、1,1,2-三甲基-2-丙烯基、1,5-己二烯基、1-乙烯基-3-丁烯基或2,4-己二烯基。
在本发明中,若无特别限定,“C2-C7炔基”是指具有2至7个碳原子的直链或支链炔基,C2-C7炔基的实例包括:乙炔基、1-丙炔基、2-丙炔基、1-丁炔基、1-甲基-2-丙炔基、2-丁炔基、3-丁炔基、1-戊炔基、1-乙基-2-丙炔基、2-戊炔基、3-戊炔基、1-甲基-2-丁炔基、4-戊炔基、1-甲基-3-丁炔基、2-甲基-3-丁炔基、1-己炔基、1-(正丙基)-2-丙炔基、2-己炔基、1-乙基-2-丁炔基、3-己炔基、1-甲基-2-戊炔基、1-甲基-3-戊炔基、4-甲基-1-戊炔基、3-甲基-1-戊炔基、5-己炔基、1-乙基-3-丁炔基、1-乙基-1-甲基-2-丙炔基、1-(异丙基)-2-丙炔基、1,1-二甲基-2-丁炔基或2,2-二甲基-3-丁炔基、1-庚炔基、1-(正丁基)-2-丙炔基、1-(仲丁基)-2-丙炔基、1-异丁基-2-丙炔基、2-庚炔基、3-庚炔基、1-甲基-2-己炔基、4-甲基-2-己炔基、5-甲基-2-己炔基、6-庚炔基、1,1-二乙基-2-丙炔基、1-甲基-1-丙基-2-丙炔基、1-异丙基-1-甲基-2-丙炔基、1,1-二甲基-2-戊炔基、1,4-二甲基-2-戊炔基或4,4-二甲基-2-戊炔基。
在本发明中,若无特别限定,“C2-C6卤代炔基”是指由相同或不同的1至9个卤素原子所取代的具有2至6个碳原子的直链或支链炔基,C2-C6卤代炔基的实例包括:氟乙炔基、氯乙炔基、溴乙炔基、碘乙炔基、3-氟-2-丙炔基、3-氯-2-丙炔基、3-溴-2-丙炔基、3-碘-2-丙炔基、4-氟-3-丁炔基、4-氯-3-丁炔基、4-溴-3-丁炔基、4-碘-3-丁炔基、4,4-二氟-2-丁炔基、4,4-二氯-2-丁炔基、4,4,4-三氟-2-丁炔基、4,4,4-三氯-2-丁炔基、3-氟-1-甲基-2-丙炔基、3-氯-1-甲基-2-丙炔基、5-氟-4-戊炔基、5-氯-4-戊炔基、5,5,5-三氟-3-戊炔基、5,5,5-三氯-3-戊炔基、4-氟-2-甲基-3-丁炔基、4-氯-2-甲基-3-丁炔基、6-氟-5-己炔基、6-氯-5-己炔基、6,6,6-三氟-4-己炔基、6,6,6-三氯-4-己炔基、5-氟-3-甲基-4-戊炔基或5-氯-3-甲基-4-戊炔基。
在本发明中,若无特别限定,“C2-C6卤代烯基”是指由相同或不同的1至11个卤素原子所取代的具有2至6个碳原子的直链或支链烯基,C2-C6卤代烯基的实例包括:1-氟乙烯基、2-氟乙烯基、1,2-二氟乙烯基、2,2-二氟乙烯基、三氟乙烯基、1-氯乙烯基、2-氯乙烯基、1,2-二氯乙烯基、2,2-二氯乙烯基、三氯乙烯基、1,2-二溴乙烯基、2,2-二溴乙烯基、三溴乙烯基、1,2-二碘乙烯基、2,2-二碘乙烯基、三碘乙烯基、1-氟-2-丙烯基、2-氟-2-丙烯基、3-氟-2-丙烯基、2,3-二氟-2-丙烯基、3,3-二氟-2-丙烯基、3,3-二氟-1-丙烯基、2,3,3-三氟-2-丙烯基、3,3,3-三氟-1-丙烯基、2-氯-3,3,3-三氟-1-丙烯基、1,2,3,3,3-五氟-1-丙烯基、1-氯-2-丙烯基、2-氯-2-丙烯基、3-氯-2-丙烯基、2,3-二氯-2-丙烯基、3,3-二氯-2-丙烯基、3,3-二氯-1-丙烯基、2,3,3-三氯-2-丙烯基、3,3,3-三氯-1-丙烯基、3-溴-2-丙烯基、3,3-二溴-2-丙烯基、3,3-二碘-2-丙烯基、2,2-二氟-1-丙烯-2-基、3,3,3-三氟-1-丙烯-2-基、3,3,3-三氯-1-丙烯-2-基、4-氟-3-丁烯基、4,4-二氟-3-丁烯基、4,4-二氟-3-丁烯-2-基、4,4,4-三氟-2-丁烯基、3,4,4-三氟-3-丁烯基、2-三氟甲基-2-丙烯基、2-三氟甲基-3,3-二氟-2-丙烯基、4,4,4-三氟-3-氯-2-丁烯基、4,4-二氯-3-丁烯基、4,4,4-三氯-2-丁烯基、2-三氯甲基-2-丙烯基、5,5-二氟-4-戊烯基、4,5,5-三氟-4-戊烯基、5,5,5-三氟-3-戊烯基、4,4,4-三氟-3-甲基-2-丁烯基、4,4,4-三氟-3-三氟甲基-2-丁烯基、5,5-二氯-4-戊烯基、4,4,4-三氯-3-甲基-2-丁烯基、6,6-二氟-5-己烯基、5,6,6-三氟-5-戊烯基、6,6,6-三氟-4-戊烯基、5,5,5-三氟-4-甲基-3-戊烯基、5,5,5-三氟-4-三氟甲基-3-戊烯基、6,6-二氯-5-己烯基或5,5,5-三氯-4-甲基-3-戊烯基。
在本发明中,“C1-C6烷硫基”是指烷基部分为如上所定义的(C1-C6烷基)-S-基,C1-C6烷硫基的实例包括:甲硫基、乙硫基、正丙硫基、异丙硫基、正丁硫基、异丁硫基、仲丁硫基或叔丁硫基。
在本发明中,“C1-C6烷基亚磺酰基”是指烷基部分为上述含义的(C1-C6烷基)-S(=O)-基,C1-C6烷基亚磺酰基的实例包括:甲基亚磺酰基、乙基亚磺酰基、正丙基亚磺酰基、异丙基亚磺酰基、正丁基亚磺酰基、异丁基亚磺酰基、仲丁基亚磺酰基或叔丁基亚磺酰基。
在本发明中,“C1-C6烷基磺酰基”是指烷基部分为上述含义的(C1-C6烷基)-S(=O)2-基,C1-C6烷基磺酰基的实例包括:甲磺酰基、乙磺酰基、正丙磺酰基、异丙磺酰基、正丁磺酰基、异丁磺酰基、仲丁磺酰基或叔丁磺酰基。
在本发明中,若无特别限定,“C1-C6卤代烷硫基”是指卤代烷基部分为如上所定义的(C1-C6卤代烷基)-S-基,C1-C6卤代烷硫基的实例包括:氟甲硫基、二氟甲硫基、三氟甲硫基、三氯甲硫基、2,2,2-三氟乙硫基、五氟乙硫基、2,2,2-三氯乙硫基、3,3,3-三氟丙硫基、1,1,2,3,3,3-六氟丙基、七氟丙硫基、1,1,1,3,3,3-六氟丙烷-2-基硫基、七氟丙烷-2-基硫基或4,4,4-三氟丁硫基。
在本发明中,若无特别限定,“C1-C6卤代烷基亚磺酰基”是指卤代烷基部分为如上所定义的(C1-C6卤代烷基)-S(=O)-基,C1-C6卤代烷基亚磺酰基的实例包括:二氟甲基亚磺酰基、三氟甲基亚磺酰基、三氯甲基亚磺酰基、2,2,2-三氟乙基亚磺酰基、2,2,2-三氯乙基亚磺酰基、五氟乙基亚磺酰基、3,3,3-三氟丙基亚磺酰基、七氟丙基亚磺酰基或七氟-2-丙基亚磺酰基。
在本发明中,若无特别限定,“C1-C6卤代烷基磺酰基”是指卤代烷基部分为如上所定义的(C1-C6卤代烷基)-S(=O)2-基,C1-C6卤代烷基磺酰基的实例包括:二氟甲磺酰基、三氟甲磺酰基、三氯甲磺酰基、2,2,2-三氟乙磺酰基、五氟乙磺酰基、3,3,3-三氟丙磺酰基、七氟丙磺酰基或七氟-2-丙磺酰基。
在本发明中,若无特别限定,“C1-C6烷硫基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)-S-(C1-C6烷基)-基,C1-C6烷硫基C1-C6烷基的实例包括:甲硫基甲基、乙硫基甲基、正丙硫基甲基、异丙硫基甲基、1-(甲硫基)乙基、2-(甲硫基)乙基、2-(乙硫基)乙基、1-(正丙硫基)乙基、2-(正丙硫基)乙基、1-(甲硫基)丙基、2-(甲硫基)丙基、3-(甲硫基)丙基、1-(乙硫基)丙基、2-(乙硫基)丙基、3-(乙硫基)丙基、1-(正丙硫基)丙基、2-(正丙硫基)丙基、3-(正丙硫基)丙基、2-(正丁硫基)乙基、2-(异丁硫基)乙基、仲丁硫基乙基、2-(叔丁硫基)乙基、戊硫基甲基或己硫基甲基。
在本发明中,若无特别限定,“C1-C6烷基亚磺酰基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)-S(=O)-(C1-C6烷基)-基,C1-C6烷基亚磺酰基C1-C6烷基的实例包括:甲基亚磺酰基甲基、乙基亚磺酰基甲基、正丙基亚磺酰基甲基、异丙基亚磺酰基甲基、1-(甲基亚磺酰基)乙基、2-(甲基亚磺酰基)乙基、2-(乙基亚磺酰基)乙基、1-(正丙基亚磺酰基)乙基、2-(正丙基亚磺酰基)乙基、1-(甲基亚磺酰基)丙基、2-(甲基亚磺酰基)丙基、3-(甲基亚磺酰基)丙基、1-(乙基亚磺酰基)丙基、2-(乙基亚磺酰基)丙基、3-(乙基亚磺酰基)丙基、1-(正丙基亚磺酰基)丙基、2-(正丙基亚磺酰基)丙基、3-(正丙基亚磺酰基)丙基、2-(正丁基亚磺酰基)乙基、2-(异丁基亚磺酰基)乙基、仲丁基亚磺酰基乙基、2-(叔丁基亚磺酰基)乙基、戊基亚磺酰基甲基或己基亚磺酰基甲基。
在本发明中,若无特别限定,“C1-C6烷基磺酰基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)-S(=O)2-(C1-C6烷基)-基,C1-C6烷基磺酰基C1-C6烷基的实例包括:甲磺酰基甲基、乙磺酰基甲基、正丙磺酰基甲基、异丙磺酰基甲基、1-(甲磺酰基)乙基、2-(甲磺酰基)乙基、2-(乙磺酰基)乙基、1-(正丙磺酰基)乙基、2-(正丙磺酰基)乙基、1-(甲磺酰基)丙基、2-(甲磺酰基)丙基、3-(甲磺酰基)丙基、1-(乙磺酰基)丙基、2-(乙磺酰基)丙基、3-(乙磺酰基)丙基、1-(正丙磺酰基)丙基、2-(正丙磺酰基)丙基、3-(正丙磺酰基)丙基、2-(正丁磺酰基)乙基、2-(异丁磺酰基)乙基、仲丁磺酰基乙基、2-(叔丁磺酰基)乙基、戊磺酰基甲基或己磺酰基甲基。
在本发明中,“C1-C6卤代烷硫基C1-C6烷基”是指卤代烷硫基部分以及烷基部分为如上所定义的(C1-C6卤代烷基)-S-(C1-C6烷基)-基,C1-C6卤代烷硫基C1-C6烷基的实例包括:2-(二氟甲硫基)乙基、2-(三氟甲硫基)乙基、2-(2,2-二氟乙硫基)乙基、2-(2,2,2-三氟乙硫基)乙基、2-(3,3-二氟丙硫基)乙基、2-(3,3,3-三氟乙硫基)乙基、3-(二氟甲硫基)丙基、3-(三氟甲硫基)丙基、3-(2,2-二氟乙硫基)丙基、3-(2,2,2-三氟乙硫基)丙基、3-(3,3-二氟丙硫基)丙基或3-(3,3,3-三氟丙硫基)丙基。
在本发明中,“C1-C6卤代烷基亚磺酰基C1-C6烷基”是指卤代烷基亚磺酰基部分以及烷基部分为如上所定义的(C1-C6卤代烷基)-S(=O)-(C1-C6烷基)-基,C1-C6卤代烷基亚磺酰基C1-C6烷基的实例包括:2-(二氟甲基亚磺酰基)乙基、2-(三氟甲基亚磺酰基)乙基、2-(2,2-二氟乙基亚磺酰基)乙基、2-(2,2,2-三氟乙基亚磺酰基)乙基、2-(3,3-二氟丙基亚磺酰基)乙基、2-(3,3,3-三氟乙基亚磺酰基)乙基、3-(二氟甲基亚磺酰基)丙基、3-(三氟甲基亚磺酰基)丙基、3-(2,2-二氟乙基亚磺酰基)丙基、3-(2,2,2-三氟乙基亚磺酰基)丙基、3-(3,3-二氟丙基亚磺酰基)丙基或3-(3,3,3三氟丙基亚磺酰基)丙基。
在本发明中,“C1-C6卤代烷基磺酰基C1-C6烷基”是指卤代烷基磺酰基部分以及烷基部分为如上所定义的(C1-C6卤代烷基)-S(=O)2-(C1-C6烷基)基,C1-C6卤代烷基磺酰基C1-C6烷基的实例包括:2-(二氟甲磺酰基)乙基、2-(三氟甲磺酰基)乙基、2-(2,2-二氟乙磺酰基)乙基、2-(2,2,2-三氟乙磺酰基)乙基、2-(3,3-二氟丙磺酰基)乙基、2-(3,3,3-三氟乙磺酰基)乙基、3-(二氟甲磺酰基)丙基、3-(三氟甲磺酰基)丙基、3-(2,2-二氟乙磺酰基)丙基、3-(2,2,2-三氟乙磺酰基)丙基、3-(3,3-二氟丙磺酰基)丙基或3-(3,3,3-三氟丙磺酰基)丙基。
在本发明中,“单(C1-C6烷基)氨基”是指烷基部分为上述含义的(C1-C6烷基)-NH-基,单(C1-C6烷基)氨基的实例包括:甲氨基、乙氨基、正丙基氨基或异丙基氨基。
在本发明中,“二(C1-C6烷基)氨基”是指烷基部分为上述含义的(C1-C6烷基)2-N-基,两个烷基可彼此不同,二(C1-C6烷基)氨基的实例包括:二甲氨基、二乙氨基或N-乙基-N-甲基氨基。
在本发明中,“单(C1-C6烷基)氨基羰基”是指烷基部分为上述含义的(C1-C6烷基)-NH-C(=O)-基,单(C1-C6烷基)氨基羰基的实例包括:甲氨基羰基、乙氨基羰基、丙氨基羰基或异丙氨基羰基。
在本发明中,“二(C1-C6烷基)氨基羰基”是指烷基部分为上述含义的(C1-C6烷基)2-N-C(=O)-基,两个烷基可彼此不同,二(C1-C6烷基)氨基羰基的实例包括:二甲氨基羰基、二乙氨基羰基、二(正丙基)氨基羰基或N-乙基-N-甲基氨基羰基。
在本发明中,“C1-C6烷基羰基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)-C(=O)-(C1-C6烷基)-基,C1-C6烷基羰基C1-C6烷基的实例包括:丙酮基、丙酰基甲基、2-甲基丙酰基甲基、三甲基乙酰基甲基、2-乙酰基乙基、2-丙酰基乙基、2(2-甲基丙酰基)乙基、2-三甲基乙酰基乙基、3-乙酰基丙基、3-丙酰基丙基、3(2-甲基丙酰基)丙基或3-三甲基乙酰基丙基。
在本发明中,“C1-C6卤代烷基羰基C1-C6烷基”是指卤代烷基部分以及烷基部分为如上所定义的(C1-C6卤代烷基)-C(=O)-(C1-C6烷基)-基,C1-C6卤代烷基羰基C1-C6烷基的实例包括:3,3,3-三氟-2-氧代丙基。
在本发明中,“C1-C6烷氧基羰基C1-C6烷基”是指烷氧基部分以及烷基部分为如上所定义的(C1-C6烷氧基)-C(=O)-(C1-C6烷基)-基,C1-C6烷氧基羰基C1-C6烷基的实例包括:甲氧基羰基甲基、乙氧基羰基甲基、正丙氧基羰基甲基、异丙氧基羰基甲基、叔丁氧基羰基甲基、2-(甲氧基羰基)乙基、2-(乙氧基羰基)乙基或2-(叔丁氧基羰基)乙基。
在本发明中,若无特别限定,“羟基C1-C6烷基”是指烷基部分为如上所定义的(羟基)-(C1-C6烷基)-基,羟基C1-C6烷基的实例包括:2-羟乙基、2-羟丙基、3-羟丙基或4-羟丁基。
在本发明中,若无特别限定,“氰基C1-C6烷基”是指烷基部分为如上所定义的(氰基)-(C1-C6烷基)-基,氰基C1-C6烷基的实例包括:氰基甲基、1-氰基乙基、2-氰基乙基、3-氰基丙基、2-氰基丙烷-2-基、1-氰基丁基、4-氰基丁基、5-氰基戊基或6-氰基己基。
在本发明中,若无特别限定,“C1-C6烷基磺酰基氧基”是指烷基部分为如上所定义的(C1-C6烷基)-S(=O)2-O-基,C1-C6烷基磺酰基氧基的实例包括:甲磺酰基氧基、乙磺酰基氧基或异丙磺酰基氧基。
在本发明中,若无特别限定,“C1-C6卤代烷基磺酰基氧基”是指卤代烷基部分为如上所定义的(C1-C6卤代烷基)-S(=O)2-O-基,C1-C6卤代烷基磺酰基氧基的实例包括:三氟甲磺酰基氧基、全氟乙磺酰基氧基、全氟丙磺酰基氧基或全氟丁磺酰基氧基。
在本发明中,若无特别限定,“C1-C6烷基羰基”是指烷基部分为如上所定义的(C1-C6烷基)-C(=O)-基,C1-C6烷基羰基的实例包括:乙酰基或丙酰基。
在本发明中,若无特别限定,“C1-C6卤代烷基羰基”是指卤代烷基部分为如上所定义的(C1-C6卤代烷基)-C(=O)-基,C1-C6卤代烷基羰基的实例包括:2,2,2-三氟乙酰基或2,2,2-三氯乙酰基。
在本发明中,“C1-C6烷氧基羰基”是指烷氧基部分为上述含义的(C1-C6烷氧基)-C(=O)-基,C1-C6烷氧基羰基的实例包括:甲氧基羰基、乙氧基羰基、正丙氧基羰基、异丙氧基羰基或叔丁氧基羰基。
在本发明中,若无特别限定,“C3-C6环烷氧基”是指环烷基部分为如上所定义的(C3-C6环烷基)-O-基,C3-C6环烷氧基的实例包括:环丙氧基、环丁氧基、环戊氧基或环己氧基。
在本发明中,若无特别限定,“C3-C6卤代环烷氧基”是指卤代环烷基部分为如上所定义的(C3-C6卤代环烷基)-O-基,C3-C6卤代环烷氧基的实例包括:1-氟环丙氧基、2-氟环丙氧基、2,2-二氟环丙氧基、2,2,3,3-四氟环丙氧基、1-氯环丙氧基、2-氯环丙氧基、2,2-二氯环丙氧基、2,2,3,3-四氯环丙氧基、1-氟环丁氧基、2-氟环丁氧基、3-氟环丁氧基、3,3-二氟环丁氧基、2-氯环丁氧基、3-氯环丁氧基、3,3-二氯环丁氧基、2-氟环戊氧基、3-氟环戊氧基、2,2-二氟环戊氧基、3,3-二氟环戊氧基、2,2-二氯环戊氧基、3,3-二氯环戊氧基、1-氟环己氧基、2-氟环己氧基、3-氟环己氧基、4-氟环己氧基、2,2-二氟环己氧基、3,3-二氟环己氧基、4,4-二氟环己氧基、1-氯环己氧基、2-氯环己氧基、3-氯环己氧基、4-氯环己氧基、2,2-二氯环己氧基、3,3-二氯环己氧基或4,4-二氯环己氧基。
在本发明中,若无特别限定,“C3-C6环烷基C1-C6烷氧基”是指环烷基部分为如上所定义的(C3-C6环烷基)-(C1-C6烷基)-O-基,C3-C6环烷基C1-C6烷氧基的实例包括:环丙基甲氧基、环丁基甲氧基、环戊基甲氧基、2-环丙基乙氧基、2-环丁基乙氧基或2-环戊基乙氧基。
在本发明中,若无特别限定,“C3-C6卤代环烷基C1-C6烷氧基”是指卤代环烷基部分为如上所定义的(C3-C6卤代环烷基)-(C1-C6烷基)-O-基,C3-C6卤代环烷基C1-C6烷氧基的实例包括:(1-氟环丙基)甲氧基、(2-氟环丙基)甲氧基、(2,2-二氟环丙基)甲氧基、(2-氯环丙基)甲氧基或(2,2-二氯环丙基)甲氧基。
在本发明中,若无特别限定,“C3-C6环烷基C1-C6烷硫基”是指环烷基部分为如上所定义的(C3-C6环烷基)-(C1-C6烷基)-S-基,C3-C6环烷基C1-C6烷硫基的实例包括:(环丙基甲基)硫基、(环丁基甲基)硫基、(环戊基甲基)硫基、(2-环丙基乙基)硫基、(2-环丁基乙基)硫基或(2-环戊基乙基)硫基。
在本发明中,若无特别限定,“C3-C6环烷基C1-C6烷基亚磺酰基”是指环烷基部分为如上所定义的(C3-C6环烷基)-(C1-C6烷基)-S(=O)基,C3-C6环烷基C1-C6烷基亚磺酰基的实例包括:(环丙基甲基)亚磺酰基、(环丁基甲基)亚磺酰基、(环戊基甲基)亚磺酰基、(2-环丙基乙基)亚磺酰基、(2-环丁基乙基)亚磺酰基或(2-环戊基乙基)亚磺酰基。
在本发明中,若无特别限定,“C3-C6环烷基C1-C6烷基磺酰基”是指环烷基部分为如上所定义的(C3-C6环烷基)-(C1-C6烷基)-S(=O)2基,C3-C6环烷基C1-C6烷基磺酰基的实例包括:(环丙基甲基)磺酰基、(环丁基甲基)磺酰基、(环戊基甲基)磺酰基、(2-环丙基乙基)磺酰基、(2-环丁基乙基)磺酰基或(2-环戊基乙基)磺酰基。
在本发明中,若无特别限定,“C3-C6卤代环烷基C1-C6烷硫基”是指卤代环烷基部分为如上所定义的(C3-C6卤代环烷基)-(C1-C6烷基)-S-基,C3-C6卤代环烷基C1-C6烷硫基的实例包括:(1-氟环丙基)甲硫基、(2-氟环丙基)甲硫基、(2,2-二氟环丙基)甲硫基、(2-氯环丙基)甲硫基或(2,2-二氯环丙基)甲硫基。
在本发明中,若无特别限定,“C3-C6卤代环烷基C1-C6烷基亚磺酰基”是指卤代环烷基部分为如上所定义的(C3-C6卤代环烷基)-(C1-C6烷基)-S(=O)-基,C3-C6卤代环烷基C1-C6烷基亚磺酰基的实例包括:(1-氟环丙基)甲基亚磺酰基、(2-氟环丙基)甲基亚磺酰基、(2,2-二氟环丙基)甲基亚磺酰基、(2-氯环丙基)甲基亚磺酰基或(2,2二氯环丙基)甲基亚磺酰基。
在本发明中,若无特别限定,“C3-C6卤代环烷基C1-C6烷基磺酰基”是指环烷基部分为如上所定义的(C3-C6卤代环烷基)-(C1-C6烷基)-S(=O)2-基,C3-C6卤代环烷基C1-C6烷基磺酰基的实例包括:(1-氟环丙基)甲磺酰基、(2-氟环丙基)甲磺酰基、(2,2-二氟环丙基)甲磺酰基、(2-氯环丙基)甲磺酰基或(2,2-二氯环丙基)甲磺酰基。
在本发明中,若无特别限定,“单(环氧乙烷-2-基)C1-C3烷基”是指烷基部分为如上所定义的(环氧乙烷-2-基)-(C1-C3烷基)-基,单(环氧乙烷-2-基)C1-C3烷基的实例包括:环氧乙烷-2-基甲基、2-(环氧乙烷-2-基)乙基或3-(环氧乙烷-2-基)丙基。
在本发明中,若无特别限定,“C1-C6烷基羰氧基”是指烷基部分为如上所定义的(C1-C6烷基)-C(=O)-O-基,C1-C6烷基羰氧基的实例包括:乙酰氧基或丙酰氧基。
在本发明中,若无特别限定,“C1-C6卤代烷基羰氧基”是指卤代烷基部分为如上所定义的(C1-C6卤代烷基)-C(=O)-O-基,C1-C6卤代烷基羰氧基的实例包括:2,2,2-三氟乙酰氧基或2,2,2-三氯乙酰氧基。
在本发明中,若无特别限定,“单(C1-C6烷基)氨基羰氧基”是指烷基部分为如上所定义的(C1-C6烷基)-NH-C(=O)-O-基,单(C1-C6烷基)氨基羰氧基的实例包括:(甲基氨基甲酰基)氧基或(乙基氨基甲酰基)氧基。
在本发明中,若无特别限定,“二(C1-C6烷基)氨基羰氧基”是指烷基部分为如上所定义的(C1-C6烷基)2-N-C(=O)-O-基,二(C1-C6烷基)氨基羰氧基的实例包括:(二甲基氨基甲酰基)氧基或(二乙基氨基甲酰基)氧基。
在本发明中,若无特别限定,“氨基羰氧基C1-C6烷基”是指烷基部分为如上所定义的(氨基)-C(=O)-O-(C1-C6烷基)-基,氨基羰氧基C1-C6烷基的实例包括:氨基甲酰基氧基甲基或氨基甲酰基氧基乙基。
在本发明中,若无特别限定,“单(C1-C6烷基)氨基羰氧基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)-NH-C(=O)-O-(C1-C6烷基)-基,单(C1-C6烷基)氨基羰氧基C1-C6烷基的实例包括:甲基氨基甲酰基氧基甲基或乙基氨基甲酰基氧基甲基。
在本发明中,若无特别限定,“二(C1-C6烷基)氨基羰氧基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)2-N-C(=O)-O-(C1-C6烷基)-基,二(C1-C6烷基)氨基羰氧基C1-C6烷基的实例包括:二甲基氨基甲酰基氧基甲基或二乙基氨基甲酰基氧基甲基。
在本发明中,若无特别限定,“C1-C6烷氧基羰氧基”是指烷氧基部分为如上所定义的(C1-C6烷氧基)-C(=O)-O-基,C1-C6烷氧基羰氧基的实例包括:甲氧基羰氧基或乙氧基羰氧基。
在本发明中,“C1-C6烷氧基羰氧基C1-C6烷基”是指烷氧基部分为如上所定义的(C1-C6烷氧基)-C(=O)-O-(C1-C6烷基)-基,C1-C6烷氧基羰氧基C1-C6烷基的实例包括:甲氧基羰氧基甲基或乙氧基羰氧基甲基。
在本发明中,“C3-C6环烷基C2-C6炔基”是指环烷基部分为如上所定义的(C3-C6环烷基)-(C2-C6炔基)-基,C3-C6环烷基C2-C6炔基的实例包括:环丙基乙炔基或环丁基乙炔基。
在本发明中,“C3-C6环烷基硫基”是指环烷基部分为如上所定义的(C3-C6环烷基)-S-基,C3-C6环烷基硫基的实例包括:环丙硫基、环丁硫基或环戊硫基。
在本发明中,“C3-C6环烷基亚磺酰基”是指环烷基部分为如上所定义的(C3-C6环烷基)-S(=O)-基,C3-C6环烷基亚磺酰基的实例包括:环丙基亚磺酰基、环丁基亚磺酰基或环戊基亚磺酰基。
在本发明中,“C3-C6环烷基磺酰基”是指环烷基部分为如上所定义的(C3-C6环烷基)-S(=O)2-基,C3-C6环烷基磺酰基的实例包括:环丙基磺酰基、环丁基磺酰基或环戊基磺酰基。
在本发明中,“C1-C6烷基羰氧基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)-C(=O)-O-(C1-C6烷基)-基,C1-C6烷基羰氧基C1-C6烷基的实例包括:乙酰氧基甲基、2-乙酰氧基乙基或丙酰基甲基。
在本发明中,“二(C1-C6烷基)氨磺酰氧基”是指烷基部分为如上所定义的(C1-C6烷基)2-N-S(=O)2-O-基,二(C1-C6烷基)氨磺酰氧基的实例包括:二甲基氨磺酰氧基或二乙基氨磺酰氧基。
在本发明中,若无特别限定,“氰基C3-C6环烷基”是指环烷基部分为如上所定义的(氰基)-(C3-C6环烷基)基,氰基C3-C6环烷基的实例包括:1-氰基环丙基、2-氰基环丙基、1-氰基环丁基、3-氰基环丁基或1-氰基环戊基。
在本发明中,若无特别限定,“C1-C6烷氧基C1-C6烷基羰基”是指烷基部分为如上所定义的(C1-C6烷基)-O-(C1-C6烷基)-C(=O)-基,C1-C6烷氧基C1-C6烷基羰基的实例包括:甲氧基乙酰基、乙氧基乙酰基、丙氧基乙酰基、异丙氧基乙酰基、丁氧基乙酰基、2-甲氧基丙酰基、3-甲氧基丙酰基、2-乙氧基丙酰基、3-乙氧基丙酰基、2-甲氧基丁酰基、4-甲氧基丁酰基、2-甲氧基戊酰基或5-甲氧基戊酰基。
在本发明中,若无特别限定,“C3-C6环烷基羰基”是指环烷基部分为如上所定义的(C3-C6环烷基)-C(=O)-基,C3-C6环烷基羰基的实例包括:环丙烷羰基、环丁烷羰基、环戊烷羰基或环己烷羰基。
在本发明中,“C3-C6环烷基C1-C6烷基羰基”是指环烷基烷基部分为如上所定义的(C3-C6环烷基C1-C6烷基)-C(=O)-基,C3-C6环烷基C1-C6烷基羰基的实例包括:2-环丙基乙酰基、2-环丁基乙酰基、2-环戊基乙酰基、2-环己基乙酰基、2-环丙基丙酰基或2-环丙基丁酰基。
在本发明中,若无特别限定,“C7-C13芳烷基羰基”是指芳烷基部分为如上所定义的(C7-C13芳烷基)-C(=O)-基,C7-C13芳烷基羰基的实例包括:苯基乙酰基、1-苯基丙酰基或2-苯基丙酰基。
在本发明中,若无特别限定,“(C1-C6烷基)硫羰基”是指烷基部分为如上所定义的(C1-C6烷基)-C(=S)-基,(C1-C6烷基)硫羰基的实例包括:甲基硫羰基、乙基硫羰基、正丙基硫羰基、异丙基硫羰基、正丁基硫羰基、异丁基硫羰基、仲丁基硫羰基、叔丁基硫羰基或正戊基硫羰基。
在本发明中,若无特别限定,“(C1-C6烷氧基)硫羰基”是指烷基部分为如上所定义的(C1-C6烷基)-O-C(=S)-基,(C1-C6烷氧基)硫羰基的实例包括:甲氧基硫羰基、乙氧基硫羰基、正丙氧基硫羰基、异丙氧基硫羰基、正丁氧基硫羰基、异丁氧基硫羰基、仲丁氧基硫羰基、叔丁氧基硫羰基、正戊氧基硫羰基、1-甲基丁氧基硫羰基、2-甲基丁氧基硫羰基、3-甲基丁氧基硫羰基、1-乙基丙氧基硫羰基、1,1-二甲基丙氧基硫羰基、1,2-二甲基丙氧基硫羰基或2,2-二甲基丙氧基硫羰基。
在本发明中,“单(C1-C6烷基)氨基硫羰基”是指烷基部分为如上所定义的(C1-C6烷基)-NH-C(=S)-基,单(C1-C6烷基)氨基硫羰基的实例包括:甲氨基硫羰基、乙氨基硫羰基、正丙氨基硫羰基、异丙氨基硫羰基、正丁氨基硫羰基、异丁氨基硫羰基、仲丁氨基硫羰基、叔丁氨基硫羰基、正戊氨基硫羰基、1-甲基丁氨基硫羰基、2-甲基丁氨基硫羰基、3-甲基丁氨基硫羰基、1-乙基丙氨基硫羰基、1,1-二甲基丙氨基硫羰基、1,2-二甲基丙氨基硫羰基、2,2-二甲基丙氨基硫羰基或正己氨基硫羰基。
在本发明中,“二(C1-C6烷基)氨基硫羰基”是指烷基部分为如上所定义的(C1-C6烷基)2-N-C(=S)-基,并且两个烷基可彼此不同,二(C1-C6烷基)氨基硫羰基的实例包括:二甲氨基硫羰基、二乙氨基硫羰基、二(正丙基)氨基硫羰基、二异丙氨基硫羰基、二丁氨基硫羰基、N-乙基-N-甲氨基硫羰基、N-甲基-N-丙基氨基硫羰基、N-异丙基-N-甲氨基硫羰基、N-丁基-N-甲氨基硫羰基、N-(仲丁基)-N-甲氨基硫羰基、N-异丁基-N-甲氨基硫羰基、N-戊基-N-甲氨基硫羰基、N-乙基-N-丙氨基硫羰基、N-乙基-N-异丙氨基硫羰基或N-乙基-N-丁氨基硫羰基。
在本发明中,“单(C1-C6烷基)氨基磺酰基”是指烷基部分为如上所定义的(C1-C6烷基)-NH-S(=O)-基,单(C1-C6烷基)氨基磺酰基的实例包括:甲氨基磺酰基、乙氨基磺酰基、正丙氨基磺酰基、异丙氨基磺酰基、正丁氨基磺酰基、异丁氨基磺酰基、仲丁氨基磺酰基、叔丁氨基磺酰基、正戊氨基磺酰基、1-甲基丁基氨基磺酰基、2-甲基丁基氨基磺酰基、3-甲基丁基氨基磺酰基、1-乙基丙基氨基磺酰基、1,1-二甲基丙基氨基磺酰基、1,2-二甲基丙基氨基磺酰基、2,2-二甲基丙基氨基磺酰基或正己氨基磺酰基。
在本发明中,“二(C1-C6烷基)氨基磺酰基”是指烷基部分为如上所定义的(C1-C6烷基)2-N-S(=O)2-基,并且两个烷基可彼此不同,二(C1-C6烷基)氨基磺酰基的实例包括:二甲氨基磺酰基、二乙氨基磺酰基、二(正丙基)氨基磺酰基、二异丙氨基磺酰基、二丁氨基磺酰基、N-乙基-N-甲氨基磺酰基、N-甲基-N-丙氨基磺酰基、N-异丙基-N-甲氨基磺酰基、N-丁基-N-甲氨基磺酰基、N-(仲丁基)-N-甲氨基磺酰基、N-异丁基-N-甲氨基磺酰基、N-戊基-N-甲氨基磺酰基、N-乙基-N-丙氨基磺基羰基、N-乙基-N-异丙基氨基磺基羰基或N-乙基-N-丁基氨基磺酰基。
在本发明中,“氨基羰基C1-C6烷基”是指烷基部分为如上所定义的H2N-C(=O)-(C1-C6烷基)-基,氨基羰基C1-C6烷基的实例包括:氨基甲酰基甲基、1-氨基甲酰基乙基、2-氨基甲酰基乙基。
在本发明中,“单(C1-C6烷基)氨基羰基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)-NH-C(=O)-(C1-C6烷基)-基,单(C1-C6烷基)氨基羰基C1-C6烷基的实例包括:N-甲基氨基甲酰基甲基、N-乙基氨基甲酰基甲基或N-(叔丁基)氨基甲酰基甲基。
在本发明中,“单(C1-C6卤代烷基)氨基羰基C1-C6烷基”是指卤代烷基部分为如上所定义的(C1-C6卤代烷基)-NH-C(=O)-(C1-C6烷基)-基,单(C1-C6卤代烷基)氨基羰基C1-C6烷基的实例包括:N-(2,2-二氟乙基)氨基甲酰基甲基、N-(2,2,2-三氟乙基)氨基甲酰基甲基、1-{N-(2,2-二氟乙基)氨基甲酰基}乙基、1-{N-(2,2-三氟乙基)氨基甲酰基]}乙基、1-{N-(2,2-二氟乙基)氨基甲酰基}-1-甲基乙基或1-{N-(2,2-三氟乙基)氨基甲酰基}-1-甲基乙基。
在本发明中,“单(C3-C6环烷基)氨基羰基C1-C6烷基”是指环烷基部分为如上所定义的(C3-C6环烷基)-NH-C(=O)-(C1-C6烷基)-基,单(C3-C6环烷基)氨基羰基C1-C6烷基的实例包括:N-环丙基氨基甲酰基甲基、N-环丁基氨基甲酰基甲基、N-环戊基氨基甲酰基甲基或N-环己基氨基甲酰基甲基。
在本发明中,“二(C1-C6烷基)氨基羰基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)2-N-C(=O)-(C1-C6烷基)-基,二(C1-C6烷基)氨基羰基C1-C6烷基的实例包括:N,N-二甲基氨基甲酰基甲基、N,N-二乙基氨基甲酰基甲基、N,N-二丙基氨基甲酰基甲基、N-乙基-N-甲基氨基甲酰基甲基或N-甲基-N-丙基氨基甲酰基甲基。
在本发明中,若无特别限定,“C1-C6烷氧基亚氨基”是指烷基部分为如上所定义的(C1-C6烷基)-O-N=C-基,C1-C6烷氧基亚氨基的实例包括:甲氧基亚氨基、乙氧基亚氨基或异丙氧基亚氨基。
在本发明中,若无特别限定,“肟基C1-C6烷基”是指烷基部分为如上所定义的HO-N=(C1-C6烷基)基,肟基C1-C6烷基的实例包括:1-(肟基)乙基、2-(肟基)乙基、1-(肟基)丙基、2-(肟基)丙基或3-(肟基)丙基。
在本发明中,若无特别限定,“C1-C6烷氧基亚氨基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)-O-N=(C1-C6烷基)基,C1-C6烷氧基亚氨基C1-C6烷基的实例包括:1-(甲氧基亚氨基)乙基、2-(甲氧基亚氨基)乙基、1-(甲氧基亚氨基)丙基、2-(甲氧基亚氨基)丙基、3-(甲氧基亚氨基)丙基、1-(乙氧基亚氨基)乙基、2-(乙氧基亚氨基)乙基、1-(乙氧基亚氨基)丙基、2-(乙氧基亚氨基)丙基、3-(乙氧基亚氨基)丙基、1-(异丙氧基亚氨基)乙基或2-(异丙氧基亚氨基)乙基。
在本发明中,若无特别限定,“氨基C1-C6烷基”是指烷基部分为如上所定义的H2N-(C1-C6烷基)-基,氨基C1-C6烷基的实例包括:氨基甲基或2-氨基乙基。
在本发明中,若无特别限定,“单(C1-C6烷基)氨基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)-NH-(C1-C6烷基)-基,单(C1-C6烷基)氨基C1-C6烷基的实例包括:N-甲氨基甲基或N-乙氨基甲基。
在本发明中,若无特别限定,“二(C1-C6烷基)氨基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)2-N-(C1-C6烷基)-基,二(C1-C6烷基)氨基C1-C6烷基的实例包括:N,N-二甲氨基甲基或N,N-二乙氨基甲基。
在本发明中,若无特别限定,“三(C1-C6烷基)甲硅烷氧基C1-C6烷基”是指烷基部分为如上所定义的(C1-C6烷基)3-Si-O-(C1-C6烷基)-基,三(C1-C6烷基)甲硅烷氧基C1-C6烷基的实例包括:三甲基甲硅烷氧基甲基、三甲基甲硅烷基氧基乙基、三乙基甲硅烷氧基甲基、三乙基甲硅烷氧基乙基、三异丙基甲硅烷氧基甲基、三异丙基甲硅烷氧基乙基、叔丁基二甲基甲硅烷氧基甲基或叔丁基二甲基甲硅烷氧基乙基。
在本发明中,“农业上可接受的盐”或“盐”是指当在由通式[I]或[II]表示的本发明化合物的结构中存在羟基、羧基或氨基等的情况或存在吡啶环的氮原子时,即为该化合物与金属或有机碱的盐、或是与无机酸或有机酸的盐,金属的实例包括:钠或钾等的碱金属以及镁或钙等的碱土金属,有机碱的实例包括:三乙胺或二异丙胺,无机酸的实例包括:磷酸、盐酸、氢溴酸、氢碘酸、硼酸或硫酸,并且有机酸的实例包括:甲酸、乙酸、乳酸、抗坏血酸、琥珀酸、富马酸、马来酸、乙二酸、柠檬酸、苯甲酸、水杨酸、酒石酸、甲磺酸、4-甲苯磺酸或三氟甲磺酸。
接着,由通式[I]表示的本发明的吡唑衍生物所包括的化合物的代表性化合物的实例示于表1至表195中,由通式[II]表示的本发明的吡唑衍生物所包括的化合物的代表性化合物的实例示于表196至表319中。然而,本发明的衍生物所包括的化合物并不限定于此。在以下描述中参考表中的化合物编号。
根据取代基的种类,本发明的吡唑衍生物所包括的化合物可以具有E-型和Z-型的几何异构体,并且本发明包括这样的E-型、Z-型或含有任意比例的E型和Z型的混合物。本发明所包括的化合物可以具有由一个或两个以上不对称碳原子和不对称硫原子的存在引起的光学异构体,并且本发明涵盖任意的光学活性物质、外消旋体或非对映异构体。
本说明书中,表中的下述符号分别表示下述相应的基团。
Me:甲基
Et:乙基
Pr:正丙基
i-Pr:异丙基
Bu:正丁基
t-Bu:叔丁基
OMe:甲氧基
O(i-Pr):异丙氧基
2-CF3:2-三氟甲基
2,6-CN2:2,6-二氰基
2,6-OEt2:2,6-二乙氧基
4-Me,2-CF3:4-甲基-2-三氟甲基
2-CF3-吡啶-3-基:2-三氟甲基吡啶-3-基
3,6-Cl2-吡啶-2-基:3,6-二氯吡啶-2-基
CH2OTBS:叔丁基二甲基甲硅烷氧基甲基
C(=O)(4-Cl)Ph:4-氯苯甲酰基
[表1]
[表2]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0053 | H | H | H | H | H | O | H | H | 2-CF<sub>2</sub>Cl | 0 |
A-0054 | H | H | H | H | H | O | H | H | 3-CF<sub>2</sub>Cl | 0 |
A-0055 | H | H | H | H | H | O | H | H | 4-CF<sub>2</sub>Cl | 0 |
A-0056 | H | H | H | H | H | O | H | H | 2-CF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-0057 | H | H | H | H | H | O | H | H | 3-CF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-0058 | H | H | H | H | H | O | H | H | 4-CF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-0059 | H | H | H | H | H | O | H | H | 2-环丙基 | 0 |
A-0060 | H | H | H | H | H | O | H | H | 3-环丙基 | 0 |
A-0061 | H | H | H | H | H | O | H | H | 4-环丙基 | 0 |
A-0062 | H | H | H | H | H | O | H | H | 2-环丁基 | 0 |
A-0063 | H | H | H | H | H | O | H | H | 3-环丁基 | 0 |
A-0064 | H | H | H | H | H | O | H | H | 4-环丁基 | 0 |
A-0065 | H | H | H | H | H | O | H | H | 2-环戊基 | 0 |
A-0066 | H | H | H | H | H | O | H | H | 3-环戊基 | 0 |
A-0067 | H | H | H | H | H | O | H | H | 4-环戊基 | 0 |
A-0068 | H | H | H | H | H | O | H | H | 2-(环丙基甲基) | 0 |
A-0069 | H | H | H | H | H | O | H | H | 3-(环丙基甲基) | 0 |
A-0070 | H | H | H | H | H | O | H | H | 4-(环丙基甲基) | 0 |
A-0071 | H | H | H | H | H | O | H | H | 2-(环丁基甲基) | 0 |
A-0072 | H | H | H | H | H | O | H | H | 3-(环丁基甲基) | 0 |
A-0073 | H | H | H | H | H | O | H | H | 4-(环丁基甲基) | 0 |
A-0074 | H | H | H | H | H | O | H | H | 2-(环戊基甲基) | 0 |
A-0075 | H | H | H | H | H | O | H | H | 3-(环戊基甲基) | 0 |
A-0076 | H | H | H | H | H | O | H | H | 4-(环戊基甲基) | 0 |
A-0077 | H | H | H | H | H | O | H | H | 2-(环丙基乙基) | 0 |
A-0078 | H | H | H | H | H | O | H | H | 3-(环丙基乙基) | 0 |
A-0079 | H | H | H | H | H | O | H | H | 4-(环丙基乙基) | 0 |
A-0080 | H | H | H | H | H | O | H | H | 2-(2,2-二氟环丙基) | 0 |
A-0081 | H | H | H | H | H | O | H | H | 3-(2,2-二氟环丙基) | 0 |
A-0082 | H | H | H | H | H | O | H | H | 4-(2,2-二氟环丙基) | 0 |
A-0083 | H | H | H | H | H | O | H | H | 2-(2,2-二氯环丙基) | 0 |
A-0084 | H | H | H | H | H | O | H | H | 3-(2,2-二氯环丙基) | 0 |
A-0085 | H | H | H | H | H | O | H | H | 4-(2,2-二氯环丙基) | 0 |
A-0086 | H | H | H | H | H | O | H | H | 2-乙烯基 | 0 |
A-0087 | H | H | H | H | H | O | H | H | 3-乙烯基 | 0 |
A-0088 | H | H | H | H | H | O | H | H | 4-乙烯基 | 0 |
A-0089 | H | H | H | H | H | O | H | H | 2-烯丙基 | 0 |
A-0090 | H | H | H | H | H | O | H | H | 3-烯丙基 | 0 |
A-0091 | H | H | H | H | H | O | H | H | 4-烯丙基 | 0 |
A-0092 | H | H | H | H | H | O | H | H | 2-(丙-1-烯-1-基) | 0 |
A-0093 | H | H | H | H | H | O | H | H | 3-(丙-1-烯-1-基) | 0 |
A-0094 | H | H | H | H | H | O | H | H | 4-(丙-1-烯-1-基) | 0 |
A-0095 | H | H | H | H | H | O | H | H | 2-(三氟乙烯基) | 0 |
A-0096 | H | H | H | H | H | O | H | H | 3-(三氟乙烯基) | 0 |
A-0097 | H | H | H | H | H | O | H | H | 4-(三氟乙烯基) | 0 |
A-0098 | H | H | H | H | H | O | H | H | 2-(2,2-二氯乙烯基) | 0 |
A-0099 | H | H | H | H | H | O | H | H | 3-(2,2-二氯乙烯基) | 0 |
A-0100 | H | H | H | H | H | O | H | H | 4-(2,2-二氯乙烯基) | 0 |
A-0101 | H | H | H | H | H | O | H | H | 2-乙炔基 | 0 |
A-0102 | H | H | H | H | H | O | H | H | 3-乙炔基 | 0 |
A-0103 | H | H | H | H | H | O | H | H | 4-乙炔基 | 0 |
A-0104 | H | H | H | H | H | O | H | H | 2-(1-丙炔-1-基) | 0 |
A-0105 | H | H | H | H | H | O | H | H | 3-(1-丙炔-1-基) | 0 |
A-0106 | H | H | H | H | H | O | H | H | 4-(1-丙炔-1-基) | 0 |
A-0107 | H | H | H | H | H | O | H | H | 2-(2-丙炔-1-基) | 0 |
A-0108 | H | H | H | H | H | O | H | H | 3-(2-丙炔-1-基) | 0 |
A-0109 | H | H | H | H | H | O | H | H | 4-(2-丙炔-1-基) | 0 |
[表3]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0110 | H | H | H | H | H | O | H | H | 2-(2-环丙基乙炔基) | 0 |
A-0111 | H | H | H | H | H | O | H | H | 3-(2-环丙基乙炔基) | 0 |
A-0112 | H | H | H | H | H | O | H | H | 4-(2-环丙基乙炔基) | 0 |
A-0113 | H | H | H | H | H | O | H | H | 2-(2-氯乙炔基) | 0 |
A-0114 | H | H | H | H | H | O | H | H | 3-(2-氯乙炔基) | 0 |
A-0115 | H | H | H | H | H | O | H | H | 4-(2-氯乙炔基) | 0 |
A-0116 | H | H | H | H | H | O | H | H | 2-(2-溴乙炔基) | 0 |
A-0117 | H | H | H | H | H | O | H | H | 3-(2-溴乙炔基) | 0 |
A-0118 | H | H | H | H | H | O | H | H | 4-(2-溴乙炔基) | 0 |
A-0119 | H | H | H | H | H | O | H | H | 2-OMe | 0 |
A-0120 | H | H | H | H | H | O | H | H | 3-OMe | 0 |
A-0121 | H | H | H | H | H | O | H | H | 4-OMe | 0 |
A-0122 | H | H | H | H | H | O | H | H | 2-OEt | 0 |
A-0123 | H | H | H | H | H | O | H | H | 3-OEt | 0 |
A-0124 | H | H | H | H | H | O | H | H | 4-OEt | 0 |
A-0125 | H | H | H | H | H | O | H | H | 2-OPr | 0 |
A-0126 | H | H | H | H | H | O | H | H | 3-OPr | 0 |
A-0127 | H | H | H | H | H | O | H | H | 4-OPr | 0 |
A-0128 | H | H | H | H | H | O | H | H | 2-O(i-Pr) | 0 |
A-0129 | H | H | H | H | H | O | H | H | 3-O(i-Pr) | 0 |
A-0130 | H | H | H | H | H | O | H | H | 4-O(i-Pr) | 0 |
A-0131 | H | H | H | H | H | O | H | H | 2-OBu | 0 |
A-0132 | H | H | H | H | H | O | H | H | 3-OBu | 0 |
A-0133 | H | H | H | H | H | O | H | H | 4-OBu | 0 |
A-0134 | H | H | H | H | H | O | H | H | 2-O(s-Bu) | 0 |
A-0135 | H | H | H | H | H | O | H | H | 3-O(s-Bu) | 0 |
A-0136 | H | H | H | H | H | O | H | H | 4-O(s-Bu) | 0 |
A-0137 | H | H | H | H | H | O | H | H | 2-O(i-Bu) | 0 |
A-0138 | H | H | H | H | H | O | H | H | 3-O(i-Bu) | 0 |
A-0139 | H | H | H | H | H | O | H | H | 4-O(i-Bu) | 0 |
A-0140 | H | H | H | H | H | O | H | H | 2-O(t-Bu) | 0 |
A-0141 | H | H | H | H | H | O | H | H | 3-O(t-Bu) | 0 |
A-0142 | H | H | H | H | H | O | H | H | 4-O(t-Bu) | 0 |
A-0143 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub> | 0 |
A-0144 | H | H | H | H | H | O | H | H | 3-OCF<sub>3</sub> | 0 |
A-0145 | H | H | H | H | H | O | H | H | 4-OCF<sub>3</sub> | 0 |
A-0146 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub> | 0 |
A-0147 | H | H | H | H | H | O | H | H | 3-OCHF<sub>2</sub> | 0 |
A-0148 | H | H | H | H | H | O | H | H | 4-OCHF<sub>2</sub> | 0 |
A-0149 | H | H | H | H | H | O | H | H | 2-OCH<sub>2</sub>CF<sub>3</sub> | 0 |
A-0150 | H | H | H | H | H | O | H | H | 3-OCH<sub>2</sub>CF<sub>3</sub> | 0 |
A-0151 | H | H | H | H | H | O | H | H | 4-OCH<sub>2</sub>CF<sub>3</sub> | 0 |
A-0152 | H | H | H | H | H | O | H | H | 2-(环丙基氧基) | 0 |
A-0153 | H | H | H | H | H | O | H | H | 3-(环丙基氧基) | 0 |
A-0154 | H | H | H | H | H | O | H | H | 4-(环丙基氧基) | 0 |
A-0155 | H | H | H | H | H | O | H | H | 2-(环丁基氧基) | 0 |
A-0156 | H | H | H | H | H | O | H | H | 3-(环丁基氧基) | 0 |
A-0157 | H | H | H | H | H | O | H | H | 4-(环丁基氧基) | 0 |
A-0158 | H | H | H | H | H | O | H | H | 2-(环戊基氧基) | 0 |
A-0159 | H | H | H | H | H | O | H | H | 3-(环戊基氧基) | 0 |
A-0160 | H | H | H | H | H | O | H | H | 4-(环戊基氧基) | 0 |
A-0161 | H | H | H | H | H | O | H | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-0162 | H | H | H | H | H | O | H | H | 3-((2,2-二氯环丙基)氧基) | 0 |
A-0163 | H | H | H | H | H | O | H | H | 4-((2,2-二氯环丙基)氧基) | 0 |
A-0164 | H | H | H | H | H | O | H | H | 2-(环丙基甲氧基) | 0 |
A-0165 | H | H | H | H | H | O | H | H | 3-(环丙基甲氧基) | 0 |
A-0166 | H | H | H | H | H | O | H | H | 4-(环丙基甲氧基) | 0 |
[表4]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0167 | H | H | H | H | H | O | H | H | 2-((2,2-二氟环丙基)甲氧基) | 0 |
A-0168 | H | H | H | H | H | O | H | H | 3-((2,2-二氟环丙基)甲氧基) | 0 |
A-0169 | H | H | H | H | H | O | H | H | 4-((2,2-二氟环丙基)甲氧基) | 0 |
A-0170 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基) | 0 |
A-0171 | H | H | H | H | H | O | H | H | 3-(环氧乙烷-2-基) | 0 |
A-0172 | H | H | H | H | H | O | H | H | 4-(环氧乙烷-2-基) | 0 |
A-0173 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基) | 0 |
A-0174 | H | H | H | H | H | O | H | H | 3-(环氧乙烷-2-基甲基) | 0 |
A-0175 | H | H | H | H | H | O | H | H | 4-(环氧乙烷-2-基甲基) | 0 |
A-0176 | H | H | H | H | H | O | H | H | 2-SMe | 0 |
A-0177 | H | H | H | H | H | O | H | H | 3-SMe | 0 |
A-0178 | H | H | H | H | H | O | H | H | 4-SMe | 0 |
A-0179 | H | H | H | H | H | O | H | H | 2-SEt | 0 |
A-0180 | H | H | H | H | H | O | H | H | 3-SEt | 0 |
A-0181 | H | H | H | H | H | O | H | H | 4-SEt | 0 |
A-0182 | H | H | H | H | H | O | H | H | 2-S(=O)Me | 0 |
A-0183 | H | H | H | H | H | O | H | H | 3-S(=O)Me | 0 |
A-0184 | H | H | H | H | H | O | H | H | 4-S(=O)Me | 0 |
A-0185 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-0186 | H | H | H | H | H | O | H | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-0187 | H | H | H | H | H | O | H | H | 4-S(=O)<sub>2</sub>Me | 0 |
A-0188 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub> | 0 |
A-0189 | H | H | H | H | H | O | H | H | 3-SCF<sub>3</sub> | 0 |
A-0190 | H | H | H | H | H | O | H | H | 4-SCF<sub>3</sub> | 0 |
A-0191 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub> | 0 |
A-0192 | H | H | H | H | H | O | H | H | 3-S(=O)CF<sub>3</sub> | 0 |
A-0193 | H | H | H | H | H | O | H | H | 4-S(=O)CF<sub>3</sub> | 0 |
A-0194 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
A-0195 | H | H | H | H | H | O | H | H | 3-S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
A-0196 | H | H | H | H | H | O | H | H | 4-S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
A-0197 | H | H | H | H | H | O | H | H | 2-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-0198 | H | H | H | H | H | O | H | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-0199 | H | H | H | H | H | O | H | H | 4-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-0200 | H | H | H | H | H | O | H | H | 2-(环丙基硫基) | 0 |
A-0201 | H | H | H | H | H | O | H | H | 3-(环丙基硫基) | 0 |
A-0202 | H | H | H | H | H | O | H | H | 4-(环丙基硫基) | 0 |
A-0203 | H | H | H | H | H | O | H | H | 2-(环丙基亚磺酰基) | 0 |
A-0204 | H | H | H | H | H | O | H | H | 3-(环丙基亚磺酰基) | 0 |
A-0205 | H | H | H | H | H | O | H | H | 4-(环丙基亚磺酰基) | 0 |
A-0206 | H | H | H | H | H | O | H | H | 2-(环丙基磺酰基) | 0 |
A-0207 | H | H | H | H | H | O | H | H | 3-(环丙基磺酰基) | 0 |
A-0208 | H | H | H | H | H | O | H | H | 4-(环丙基磺酰基) | 0 |
A-0209 | H | H | H | H | H | O | H | H | 2-((环丙基甲基)硫基) | 0 |
A-0210 | H | H | H | H | H | O | H | H | 3-((环丙基甲基)硫基) | 0 |
A-0211 | H | H | H | H | H | O | H | H | 4-((环丙基甲基)硫基) | 0 |
A-0212 | H | H | H | H | H | O | H | H | 2-((环丙基甲基)亚磺酰基) | 0 |
A-0213 | H | H | H | H | H | O | H | H | 3-((环丙基甲基)亚磺酰基) | 0 |
A-0214 | H | H | H | H | H | O | H | H | 4-((环丙基甲基)亚磺酰基) | 0 |
A-0215 | H | H | H | H | H | O | H | H | 2-((环丙基甲基)磺酰基) | 0 |
A-0216 | H | H | H | H | H | O | H | H | 3-((环丙基甲基)磺酰基) | 0 |
A-0217 | H | H | H | H | H | O | H | H | 4-((环丙基甲基)磺酰基) | 0 |
A-0218 | H | H | H | H | H | O | H | H | 2-(((2,2-二氟环丙基)甲基)硫基) | 0 |
A-0219 | H | H | H | H | H | O | H | H | 3-(((2,2-二氟环丙基)甲基)硫基) | 0 |
A-0220 | H | H | H | H | H | O | H | H | 4-(((2,2-二氟环丙基)甲基)硫基) | 0 |
A-0221 | H | H | H | H | H | O | H | H | 2-(((2,2-二氟环丙基)甲基)亚磺酰基) | 0 |
A-0222 | H | H | H | H | H | O | H | H | 3-(((2,2-二氟环丙基)甲基)亚磺酰基) | 0 |
A-0223 | H | H | H | H | H | O | H | H | 4-(((2,2-二氟环丙基)甲基)亚磺酰基) | 0 |
[表5]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0224 | H | H | H | H | H | O | H | H | 2-(((2,2-二氟环丙基)甲基)磺酰基) | 0 |
A-0225 | H | H | H | H | H | O | H | H | 3-(((2,2-二氟环丙基)甲基)磺酰基) | 0 |
A-0226 | H | H | H | H | H | O | H | H | 4-(((2,2-二氟环丙基)甲基)磺酰基) | 0 |
A-0227 | H | H | H | H | H | O | H | H | 2-C(=O)Me | 0 |
A-0228 | H | H | H | H | H | O | H | H | 3-C(=O)Me | 0 |
A-0229 | H | H | H | H | H | O | H | H | 4-C(=O)Me | 0 |
A-0230 | H | H | H | H | H | O | H | H | 2-C(=O)Et | 0 |
A-0231 | H | H | H | H | H | O | H | H | 3-C(=O)Et | 0 |
A-0232 | H | H | H | H | H | O | H | H | 4-C(=O)Et | 0 |
A-0233 | H | H | H | H | H | O | H | H | 2-C(=O)CF<sub>3</sub> | 0 |
A-0234 | H | H | H | H | H | O | H | H | 3-C(=O)CF<sub>3</sub> | 0 |
A-0235 | H | H | H | H | H | O | H | H | 4-C(=O)CF<sub>3</sub> | 0 |
A-0236 | H | H | H | H | H | O | H | H | 2-C(=O)OMe | 0 |
A-0237 | H | H | H | H | H | O | H | H | 3-C(=O)OMe | 0 |
A-0238 | H | H | H | H | H | O | H | H | 4-C(=O)OMe | 0 |
A-0239 | H | H | H | H | H | O | H | H | 2-C(=O)OEt | 0 |
A-0240 | H | H | H | H | H | O | H | H | 3-C(=O)OEt | 0 |
A-0241 | H | H | H | H | H | O | H | H | 4-C(=O)OEt | 0 |
A-0242 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub> | 0 |
A-0243 | H | H | H | H | H | O | H | H | 3-C(=O)NH<sub>2</sub> | 0 |
A-0244 | H | H | H | H | H | O | H | H | 4-C(=O)NH<sub>2</sub> | 0 |
A-0245 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe | 0 |
A-0246 | H | H | H | H | H | O | H | H | 3-C(=O)NHMe | 0 |
A-0247 | H | H | H | H | H | O | H | H | 4-C(=O)NHMe | 0 |
A-0248 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub> | 0 |
A-0249 | H | H | H | H | H | O | H | H | 3-C(=O)NMe<sub>2</sub> | 0 |
A-0250 | H | H | H | H | H | O | H | H | 4-C(=O)NMe<sub>2</sub> | 0 |
A-0251 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
A-0252 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
A-0253 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
A-0254 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
A-0255 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
A-0256 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
A-0257 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 0 |
A-0258 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 0 |
A-0259 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 0 |
A-0260 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH | 0 |
A-0261 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OH | 0 |
A-0262 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OH | 0 |
A-0263 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
A-0264 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
A-0265 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
A-0266 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
A-0267 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
A-0268 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
A-0269 | H | H | H | H | H | O | H | H | 2-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 0 |
A-0270 | H | H | H | H | H | O | H | H | 3-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 0 |
A-0271 | H | H | H | H | H | O | H | H | 4-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 0 |
A-0272 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 0 |
A-0273 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 0 |
A-0274 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 0 |
A-0275 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCF<sub>3</sub> | 0 |
A-0276 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OCF<sub>3</sub> | 0 |
A-0277 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OCF<sub>3</sub> | 0 |
A-0278 | H | H | H | H | H | O | H | H | 2-CF<sub>2</sub>OCH<sub>3</sub> | 0 |
A-0279 | H | H | H | H | H | O | H | H | 3-CF<sub>2</sub>OCH<sub>3</sub> | 0 |
A-0280 | H | H | H | H | H | O | H | H | 4-CF<sub>2</sub>OCH<sub>3</sub> | 0 |
[表6]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0281 | H | H | H | H | H | O | H | H | 2-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 0 |
A-0282 | H | H | H | H | H | O | H | H | 3-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 0 |
A-0283 | H | H | H | H | H | O | H | H | 4-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 0 |
A-0284 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub> | 0 |
A-0285 | H | H | H | H | H | O | H | H | 3-OC(=O)CH<sub>3</sub> | 0 |
A-0286 | H | H | H | H | H | O | H | H | 4-OC(=O)CH<sub>3</sub> | 0 |
A-0287 | H | H | H | H | H | O | H | H | 2-OC(=O)CF<sub>3</sub> | 0 |
A-0288 | H | H | H | H | H | O | H | H | 3-OC(=O)CF<sub>3</sub> | 0 |
A-0289 | H | H | H | H | H | O | H | H | 4-OC(=O)CF<sub>3</sub> | 0 |
A-0290 | H | H | H | H | H | O | H | H | 2-OC(=O)NH<sub>2</sub> | 0 |
A-0291 | H | H | H | H | H | O | H | H | 3-OC(=O)NH<sub>2</sub> | 0 |
A-0292 | H | H | H | H | H | O | H | H | 4-OC(=O)NH<sub>2</sub> | 0 |
A-0293 | H | H | H | H | H | O | H | H | 2-OC(=O)NHCH<sub>3</sub> | 0 |
A-0294 | H | H | H | H | H | O | H | H | 3-OC(=O)NHCH<sub>3</sub> | 0 |
A-0295 | H | H | H | H | H | O | H | H | 4-OC(=O)NHCH<sub>3</sub> | 0 |
A-0296 | H | H | H | H | H | O | H | H | 2-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
A-0297 | H | H | H | H | H | O | H | H | 3-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
A-0298 | H | H | H | H | H | O | H | H | 4-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
A-0299 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 0 |
A-0300 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 0 |
A-0301 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 0 |
A-0302 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 0 |
A-0303 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 0 |
A-0304 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 0 |
A-0305 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
A-0306 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
A-0307 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
A-0308 | H | H | H | H | H | O | H | H | 2-OC(=O)OCH<sub>3</sub> | 0 |
A-0309 | H | H | H | H | H | O | H | H | 3-OC(=O)OCH<sub>3</sub> | 0 |
A-0310 | H | H | H | H | H | O | H | H | 4-OC(=O)OCH<sub>3</sub> | 0 |
A-0311 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 0 |
A-0312 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 0 |
A-0313 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 0 |
A-0314 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 0 |
A-0315 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 0 |
A-0316 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 0 |
A-0317 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
A-0318 | H | H | H | H | H | O | H | H | 3-OS(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
A-0319 | H | H | H | H | H | O | H | H | 4-OS(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
A-0320 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
A-0321 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
A-0322 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
A-0323 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
A-0324 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
A-0325 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
A-0326 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
A-0327 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
A-0328 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
A-0329 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub> | 0 |
A-0330 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>SCF<sub>3</sub> | 0 |
A-0331 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>SCF<sub>3</sub> | 0 |
A-0332 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 0 |
A-0333 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 0 |
A-0334 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 0 |
A-0335 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
A-0336 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
A-0337 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
[表7]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0338 | H | H | H | H | H | O | H | H | 2-苯基 | 0 |
A-0339 | H | H | H | H | H | O | H | H | 3-苯基 | 0 |
A-0340 | H | H | H | H | H | O | H | H | 4-苯基 | 0 |
A-0341 | H | H | H | H | H | O | H | H | 2-(苯氧基) | 0 |
A-0342 | H | H | H | H | H | O | H | H | 3-(苯氧基) | 0 |
A-0343 | H | H | H | H | H | O | H | H | 4-(苯氧基) | 0 |
A-0344 | H | H | H | H | H | O | H | H | 2-苯甲基 | 0 |
A-0345 | H | H | H | H | H | O | H | H | 3-苯甲基 | 0 |
A-0346 | H | H | H | H | H | O | H | H | 4-苯甲基 | 0 |
A-0347 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基) | 0 |
A-0348 | H | H | H | H | H | O | H | H | 3-(苯甲基氧基) | 0 |
A-0349 | H | H | H | H | H | O | H | H | 4-(苯甲基氧基) | 0 |
A-0350 | H | H | H | H | H | O | H | H | 2-((2-氟苯甲基)氧基) | 0 |
A-0351 | H | H | H | H | H | O | H | H | 3-((2-氟苯甲基)氧基) | 0 |
A-0352 | H | H | H | H | H | O | H | H | 4-((2-氟苯甲基)氧基) | 0 |
A-0353 | H | H | H | H | H | O | H | H | 2-((3-氟苯甲基)氧基) | 0 |
A-0354 | H | H | H | H | H | O | H | H | 3-((3-氟苯甲基)氧基) | 0 |
A-0355 | H | H | H | H | H | O | H | H | 4-((3-氟苯甲基)氧基) | 0 |
A-0356 | H | H | H | H | H | O | H | H | 2-((4-氟苯甲基)氧基) | 0 |
A-0357 | H | H | H | H | H | O | H | H | 3-((4-氟苯甲基)氧基) | 0 |
A-0358 | H | H | H | H | H | O | H | H | 4-((4-氟苯甲基)氧基) | 0 |
A-0359 | H | H | H | H | H | O | H | H | 2-((2-氯苯甲基)氧基) | 0 |
A-0360 | H | H | H | H | H | O | H | H | 3-((2-氯苯甲基)氧基) | 0 |
A-0361 | H | H | H | H | H | O | H | H | 4-((2-氯苯甲基)氧基) | 0 |
A-0362 | H | H | H | H | H | O | H | H | 2-((3-氯苯甲基)氧基) | 0 |
A-0363 | H | H | H | H | H | O | H | H | 3-((3-氯苯甲基)氧基) | 0 |
A-0364 | H | H | H | H | H | O | H | H | 4-((3-氯苯甲基)氧基) | 0 |
A-0365 | H | H | H | H | H | O | H | H | 2-((4-氯苯甲基)氧基) | 0 |
A-0366 | H | H | H | H | H | O | H | H | 3-((4-氯苯甲基)氧基) | 0 |
A-0367 | H | H | H | H | H | O | H | H | 4-((4-氯苯甲基)氧基) | 0 |
A-0368 | H | H | H | H | H | O | H | H | 2-((2-甲基苯甲基)氧基) | 0 |
A-0369 | H | H | H | H | H | O | H | H | 3-((2-甲基苯甲基)氧基) | 0 |
A-0370 | H | H | H | H | H | O | H | H | 4-((2-甲基苯甲基)氧基) | 0 |
A-0371 | H | H | H | H | H | O | H | H | 2-((3-甲基苯甲基)氧基) | 0 |
A-0372 | H | H | H | H | H | O | H | H | 3-((3-甲基苯甲基)氧基) | 0 |
A-0373 | H | H | H | H | H | O | H | H | 4-((3-甲基苯甲基)氧基) | 0 |
A-0374 | H | H | H | H | H | O | H | H | 2-((4-甲基苯甲基)氧基) | 0 |
A-0375 | H | H | H | H | H | O | H | H | 3-((4-甲基苯甲基)氧基) | 0 |
A-0376 | H | H | H | H | H | O | H | H | 4-((4-甲基苯甲基)氧基) | 0 |
A-0377 | H | H | H | H | H | O | H | H | 2-((2-(三氟甲基)苯甲基)氧基) | 0 |
A-0378 | H | H | H | H | H | O | H | H | 3-((2-(三氟甲基)苯甲基)氧基) | 0 |
A-0379 | H | H | H | H | H | O | H | H | 4-((2-(三氟甲基)苯甲基)氧基) | 0 |
A-0380 | H | H | H | H | H | O | H | H | 2-((3-(三氟甲基)苯甲基)氧基) | 0 |
A-0381 | H | H | H | H | H | O | H | H | 3-((3-(三氟甲基)苯甲基)氧基) | 0 |
A-0382 | H | H | H | H | H | O | H | H | 4-((3-(三氟甲基)苯甲基)氧基) | 0 |
A-0383 | H | H | H | H | H | O | H | H | 2-((4-(三氟甲基)苯甲基)氧基) | 0 |
A-0384 | H | H | H | H | H | O | H | H | 3-((4-(三氟甲基)苯甲基)氧基) | 0 |
A-0385 | H | H | H | H | H | O | H | H | 4-((4-(三氟甲基)苯甲基)氧基) | 0 |
A-0386 | H | H | H | H | H | O | H | H | 2-((2-甲氧基苯甲基)氧基) | 0 |
A-0387 | H | H | H | H | H | O | H | H | 3-((2-甲氧基苯甲基)氧基) | 0 |
A-0388 | H | H | H | H | H | O | H | H | 4-((2-甲氧基苯甲基)氧基) | 0 |
A-0389 | H | H | H | H | H | O | H | H | 2-((3-甲氧基苯甲基)氧基) | 0 |
A-0390 | H | H | H | H | H | O | H | H | 3-((3-甲氧基苯甲基)氧基) | 0 |
A-0391 | H | H | H | H | H | O | H | H | 4-((3-甲氧基苯甲基)氧基) | 0 |
A-0392 | H | H | H | H | H | O | H | H | 2-((4-甲氧基苯甲基)氧基) | 0 |
A-0393 | H | H | H | H | H | O | H | H | 3-((4-甲氧基苯甲基)氧基) | 0 |
A-0394 | H | H | H | H | H | O | H | H | 4-((4-甲氧基苯甲基)氧基) | 0 |
[表8]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0395 | H | H | H | H | H | O | H | H | 2-((2-(三氟甲氧基)苯甲基)氧基) | 0 |
A-0396 | H | H | H | H | H | O | H | H | 3-((2-(三氟甲氧基)苯甲基)氧基) | 0 |
A-0397 | H | H | H | H | H | O | H | H | 4-((2-(三氟甲氧基)苯甲基)氧基) | 0 |
A-0398 | H | H | H | H | H | O | H | H | 2-((3-(三氟甲氧基)苯甲基)氧基) | 0 |
A-0399 | H | H | H | H | H | O | H | H | 3-((3-(三氟甲氧基)苯甲基)氧基) | 0 |
A-0400 | H | H | H | H | H | O | H | H | 4-((3-(三氟甲氧基)苯甲基)氧基) | 0 |
A-0401 | H | H | H | H | H | O | H | H | 2-((4-(三氟甲氧基)苯甲基)氧基) | 0 |
A-0402 | H | H | H | H | H | O | H | H | 3-((4-(三氟甲氧基)苯甲基)氧基) | 0 |
A-0403 | H | H | H | H | H | O | H | H | 4-((4-(三氟甲氧基)苯甲基)氧基) | 0 |
A-0404 | H | H | H | H | H | O | H | H | 2-((2-(甲基硫基)苯甲基)氧基) | 0 |
A-0405 | H | H | H | H | H | O | H | H | 3-((2-(甲基硫基)苯甲基)氧基) | 0 |
A-0406 | H | H | H | H | H | O | H | H | 4-((2-(甲基硫基)苯甲基)氧基) | 0 |
A-0407 | H | H | H | H | H | O | H | H | 2-((3-(甲基硫基)苯甲基)氧基) | 0 |
A-0408 | H | H | H | H | H | O | H | H | 3-((3-(甲基硫基)苯甲基)氧基) | 0 |
A-0409 | H | H | H | H | H | O | H | H | 4-((3-(甲基硫基)苯甲基)氧基) | 0 |
A-0410 | H | H | H | H | H | O | H | H | 2-((4-(甲基硫基)苯甲基)氧基) | 0 |
A-0411 | H | H | H | H | H | O | H | H | 3-((4-(甲基硫基)苯甲基)氧基) | 0 |
A-0412 | H | H | H | H | H | O | H | H | 4-((4-(甲基硫基)苯甲基)氧基) | 0 |
A-0413 | H | H | H | H | H | O | H | H | 2-((2-(甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0414 | H | H | H | H | H | O | H | H | 3-((2-(甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0415 | H | H | H | H | H | O | H | H | 4-((2-(甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0416 | H | H | H | H | H | O | H | H | 2-((3-(甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0417 | H | H | H | H | H | O | H | H | 3-((3-(甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0418 | H | H | H | H | H | O | H | H | 4-((3-(甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0419 | H | H | H | H | H | O | H | H | 2-((4-(甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0420 | H | H | H | H | H | O | H | H | 3-((4-(甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0421 | H | H | H | H | H | O | H | H | 4-((4-(甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0422 | H | H | H | H | H | O | H | H | 2-((2-(甲基磺酰基)苯甲基)氧基) | 0 |
A-0423 | H | H | H | H | H | O | H | H | 3-((2-(甲基磺酰基)苯甲基)氧基) | 0 |
A-0424 | H | H | H | H | H | O | H | H | 4-((2-(甲基磺酰基)苯甲基)氧基) | 0 |
A-0425 | H | H | H | H | H | O | H | H | 2-((3-(甲基磺酰基)苯甲基)氧基) | 0 |
A-0426 | H | H | H | H | H | O | H | H | 3-((3-(甲基磺酰基)苯甲基)氧基) | 0 |
A-0427 | H | H | H | H | H | O | H | H | 4-((3-(甲基磺酰基)苯甲基)氧基) | 0 |
A-0428 | H | H | H | H | H | O | H | H | 2-((4-(甲基磺酰基)苯甲基)氧基) | 0 |
A-0429 | H | H | H | H | H | O | H | H | 3-((4-(甲基磺酰基)苯甲基)氧基) | 0 |
A-0430 | H | H | H | H | H | O | H | H | 4-((4-(甲基磺酰基)苯甲基)氧基) | 0 |
A-0431 | H | H | H | H | H | O | H | H | 2-((2-(三氟甲基硫基)苯甲基)氧基) | 0 |
A-0432 | H | H | H | H | H | O | H | H | 3-((2-(三氟甲基硫基)苯甲基)氧基) | 0 |
A-0433 | H | H | H | H | H | O | H | H | 4-((2-(三氟甲基硫基)苯甲基)氧基) | 0 |
A-0434 | H | H | H | H | H | O | H | H | 2-((3-(三氟甲基硫基)苯甲基)氧基) | 0 |
A-0435 | H | H | H | H | H | O | H | H | 3-((3-(三氟甲基硫基)苯甲基)氧基) | 0 |
A-0436 | H | H | H | H | H | O | H | H | 4-((3-(三氟甲基硫基)苯甲基)氧基) | 0 |
A-0437 | H | H | H | H | H | O | H | H | 2-((4-(三氟甲基硫基)苯甲基)氧基) | 0 |
A-0438 | H | H | H | H | H | O | H | H | 3-((4-(三氟甲基硫基)苯甲基)氧基) | 0 |
A-0439 | H | H | H | H | H | O | H | H | 4-((4-(三氟甲基硫基)苯甲基)氧基) | 0 |
A-0440 | H | H | H | H | H | O | H | H | 2-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0441 | H | H | H | H | H | O | H | H | 3-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0442 | H | H | H | H | H | O | H | H | 4-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0443 | H | H | H | H | H | O | H | H | 2-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0444 | H | H | H | H | H | O | H | H | 3-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0445 | H | H | H | H | H | O | H | H | 4-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0446 | H | H | H | H | H | O | H | H | 2-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0447 | H | H | H | H | H | O | H | H | 3-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0448 | H | H | H | H | H | O | H | H | 4-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
A-0449 | H | H | H | H | H | O | H | H | 2-((2-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
A-0450 | H | H | H | H | H | O | H | H | 3-((2-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
A-0451 | H | H | H | H | H | O | H | H | 4-((2-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
[表9]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0452 | H | H | H | H | H | O | H | H | 2-((3-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
A-0453 | H | H | H | H | H | O | H | H | 3-((3-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
A-0454 | H | H | H | H | H | O | H | H | 4-((3-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
A-0455 | H | H | H | H | H | O | H | H | 2-((4-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
A-0456 | H | H | H | H | H | O | H | H | 3-((4-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
A-0457 | H | H | H | H | H | O | H | H | 4-((4-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
A-0458 | H | H | H | H | H | O | H | H | 2-((2-氨基苯甲基)氧基) | 0 |
A-0459 | H | H | H | H | H | O | H | H | 3-((2-氨基苯甲基)氧基) | 0 |
A-0460 | H | H | H | H | H | O | H | H | 4-((2-氨基苯甲基)氧基) | 0 |
A-0461 | H | H | H | H | H | O | H | H | 2-((3-氨基苯甲基)氧基) | 0 |
A-0462 | H | H | H | H | H | O | H | H | 3-((3-氨基苯甲基)氧基) | 0 |
A-0463 | H | H | H | H | H | O | H | H | 4-((3-氨基苯甲基)氧基) | 0 |
A-0464 | H | H | H | H | H | O | H | H | 2-((4-氨基苯甲基)氧基) | 0 |
A-0465 | H | H | H | H | H | O | H | H | 3-((4-氨基苯甲基)氧基) | 0 |
A-0466 | H | H | H | H | H | O | H | H | 4-((4-氨基苯甲基)氧基) | 0 |
A-0467 | H | H | H | H | H | O | H | H | 2-((2-(甲基氨基)苯甲基)氧基) | 0 |
A-0468 | H | H | H | H | H | O | H | H | 3-((2-(甲基氨基)苯甲基)氧基) | 0 |
A-0469 | H | H | H | H | H | O | H | H | 4-((2-(甲基氨基)苯甲基)氧基) | 0 |
A-0470 | H | H | H | H | H | O | H | H | 2-((3-(甲基氨基)苯甲基)氧基) | 0 |
A-0471 | H | H | H | H | H | O | H | H | 3-((3-(甲基氨基)苯甲基)氧基) | 0 |
A-0472 | H | H | H | H | H | O | H | H | 4-((3-(甲基氨基)苯甲基)氧基) | 0 |
A-0473 | H | H | H | H | H | O | H | H | 2-((4-(甲基氨基)苯甲基)氧基) | 0 |
A-0474 | H | H | H | H | H | O | H | H | 3-((4-(甲基氨基)苯甲基)氧基) | 0 |
A-0475 | H | H | H | H | H | O | H | H | 4-((4-(甲基氨基)苯甲基)氧基) | 0 |
A-0476 | H | H | H | H | H | O | H | H | 2-((2-(二甲基氨基)苯甲基)氧基) | 0 |
A-0477 | H | H | H | H | H | O | H | H | 3-((2-(二甲基氨基)苯甲基)氧基) | 0 |
A-0478 | H | H | H | H | H | O | H | H | 4-((2-(二甲基氨基)苯甲基)氧基) | 0 |
A-0479 | H | H | H | H | H | O | H | H | 2-((3-(二甲基氨基)苯甲基)氧基) | 0 |
A-0480 | H | H | H | H | H | O | H | H | 3-((3-(二甲基氨基)苯甲基)氧基) | 0 |
A-0481 | H | H | H | H | H | O | H | H | 4-((3-(二甲基氨基)苯甲基)氧基) | 0 |
A-0482 | H | H | H | H | H | O | H | H | 2-((4-(二甲基氨基)苯甲基)氧基) | 0 |
A-0483 | H | H | H | H | H | O | H | H | 3-((4-(二甲基氨基)苯甲基)氧基) | 0 |
A-0484 | H | H | H | H | H | O | H | H | 4-((4-(二甲基氨基)苯甲基)氧基) | 0 |
A-0485 | H | H | H | H | H | O | H | H | 2-((2-氰基苯甲基)氧基) | 0 |
A-0486 | H | H | H | H | H | O | H | H | 3-((2-氰基苯甲基)氧基) | 0 |
A-0487 | H | H | H | H | H | O | H | H | 4-((2-氰基苯甲基)氧基) | 0 |
A-0488 | H | H | H | H | H | O | H | H | 2-((3-氰基苯甲基)氧基) | 0 |
A-0489 | H | H | H | H | H | O | H | H | 3-((3-氰基苯甲基)氧基) | 0 |
A-0490 | H | H | H | H | H | O | H | H | 4-((3-氰基苯甲基)氧基) | 0 |
A-0491 | H | H | H | H | H | O | H | H | 2-((4-氰基苯甲基)氧基) | 0 |
A-0492 | H | H | H | H | H | O | H | H | 3-((4-氰基苯甲基)氧基) | 0 |
A-0493 | H | H | H | H | H | O | H | H | 4-((4-氰基苯甲基)氧基) | 0 |
A-0494 | H | H | H | H | H | O | H | H | 2-((2-硝基苯甲基)氧基) | 0 |
A-0495 | H | H | H | H | H | O | H | H | 3-((2-硝基苯甲基)氧基) | 0 |
A-0496 | H | H | H | H | H | O | H | H | 4-((2-硝基苯甲基)氧基) | 0 |
A-0497 | H | H | H | H | H | O | H | H | 2-((3-硝基苯甲基)氧基) | 0 |
A-0498 | H | H | H | H | H | O | H | H | 3-((3-硝基苯甲基)氧基) | 0 |
A-0499 | H | H | H | H | H | O | H | H | 4-((3-硝基苯甲基)氧基) | 0 |
A-0500 | H | H | H | H | H | O | H | H | 2-((4-硝基苯甲基)氧基) | 0 |
A-0501 | H | H | H | H | H | O | H | H | 3-((4-硝基苯甲基)氧基) | 0 |
A-0502 | H | H | H | H | H | O | H | H | 4-((4-硝基苯甲基)氧基) | 0 |
A-0503 | H | H | H | H | H | O | H | H | 2-NH2 | 0 |
A-0504 | H | H | H | H | H | O | H | H | 3-NH2 | 0 |
A-0505 | H | H | H | H | H | O | H | H | 4-NH2 | 0 |
A-0506 | H | H | H | H | H | O | H | H | 2-NHMe | 0 |
A-0507 | H | H | H | H | H | O | H | H | 3-NHMe | 0 |
A-0508 | H | H | H | H | H | O | H | H | 4-NHMe | 0 |
[表10]
[表11]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0566 | H | H | H | H | H | O | H | H | 3-F,5-Cl | 0 |
A-0567 | H | H | H | H | H | O | H | H | 3-F,6-Cl | 0 |
A-0568 | H | H | H | H | H | O | H | H | 4-F,2-Cl | 0 |
A-0569 | H | H | H | H | H | O | H | H | 4-F,3-Cl | 0 |
A-0570 | H | H | H | H | H | O | H | H | 2-F,3-Me | 0 |
A-0571 | H | H | H | H | H | O | H | H | 2-F,4-Me | 0 |
A-0572 | H | H | H | H | H | O | H | H | 2-F,5-Me | 0 |
A-0573 | H | H | H | H | H | O | H | H | 2-F,6-Me | 0 |
A-0574 | H | H | H | H | H | O | H | H | 3-F,2-Me | 0 |
A-0575 | H | H | H | H | H | O | H | H | 3-F,4-Me | 0 |
A-0576 | H | H | H | H | H | O | H | H | 3-F,5-Me | 0 |
A-0577 | H | H | H | H | H | O | H | H | 3-F,6-Me | 0 |
A-0578 | H | H | H | H | H | O | H | H | 4-F,2-Me | 0 |
A-0579 | H | H | H | H | H | O | H | H | 4-F,3-Me | 0 |
A-0580 | H | H | H | H | H | O | H | H | 2-F,3-CF<sub>3</sub> | 0 |
A-0581 | H | H | H | H | H | O | H | H | 2-F,4-CF<sub>3</sub> | 0 |
A-0582 | H | H | H | H | H | O | H | H | 2-F,5-CF<sub>3</sub> | 0 |
A-0583 | H | H | H | H | H | O | H | H | 2-F,6-CF<sub>3</sub> | 0 |
A-0584 | H | H | H | H | H | O | H | H | 3-F,2-CF<sub>3</sub> | 0 |
A-0585 | H | H | H | H | H | O | H | H | 3-F,4-CF<sub>3</sub> | 0 |
A-0586 | H | H | H | H | H | O | H | H | 3-F,5-CF<sub>3</sub> | 0 |
A-0587 | H | H | H | H | H | O | H | H | 3-F,6-CF<sub>3</sub> | 0 |
A-0588 | H | H | H | H | H | O | H | H | 4-F,2-CF<sub>3</sub> | 0 |
A-0589 | H | H | H | H | H | O | H | H | 4-F,3-CF<sub>3</sub> | 0 |
A-0590 | H | H | H | H | H | O | H | H | 2-F,3-OMe | 0 |
A-0591 | H | H | H | H | H | O | H | H | 2-F,4-OMe | 0 |
A-0592 | H | H | H | H | H | O | H | H | 2-F,5-OMe | 0 |
A-0593 | H | H | H | H | H | O | H | H | 2-F,6-OMe | 0 |
A-0594 | H | H | H | H | H | O | H | H | 3-F,2-OMe | 0 |
A-0595 | H | H | H | H | H | O | H | H | 3-F,4-OMe | 0 |
A-0596 | H | H | H | H | H | O | H | H | 3-F,5-OMe | 0 |
A-0597 | H | H | H | H | H | O | H | H | 3-F,6-OMe | 0 |
A-0598 | H | H | H | H | H | O | H | H | 4-F,2-OMe | 0 |
A-0599 | H | H | H | H | H | O | H | H | 4-F,3-OMe | 0 |
A-0600 | H | H | H | H | H | O | H | H | 2,3-Cl<sub>2</sub> | 0 |
A-0601 | H | H | H | H | H | O | H | H | 2,4-Cl<sub>2</sub> | 0 |
A-0602 | H | H | H | H | H | O | H | H | 2,5-Cl<sub>2</sub> | 0 |
A-0603 | H | H | H | H | H | O | H | H | 2,6-Cl<sub>2</sub> | 0 |
A-0604 | H | H | H | H | H | O | H | H | 3,4-Cl<sub>2</sub> | 0 |
A-0605 | H | H | H | H | H | O | H | H | 3,5-Cl<sub>2</sub> | 0 |
A-0606 | H | H | H | H | H | O | H | H | 2-Cl,3-Me | 0 |
A-0607 | H | H | H | H | H | O | H | H | 2-Cl,4-Me | 0 |
A-0608 | H | H | H | H | H | O | H | H | 2-Cl,5-Me | 0 |
A-0609 | H | H | H | H | H | O | H | H | 2-Cl,6-Me | 0 |
A-0610 | H | H | H | H | H | O | H | H | 3-Cl,2-Me | 0 |
A-0611 | H | H | H | H | H | O | H | H | 3-Cl,4-Me | 0 |
A-0612 | H | H | H | H | H | O | H | H | 3-Cl,5-Me | 0 |
A-0613 | H | H | H | H | H | O | H | H | 3-Cl,6-Me | 0 |
A-0614 | H | H | H | H | H | O | H | H | 4-Cl,2-Me | 0 |
A-0615 | H | H | H | H | H | O | H | H | 4-Cl,3-Me | 0 |
A-0616 | H | H | H | H | H | O | H | H | 2-Cl,3-CF<sub>3</sub> | 0 |
A-0617 | H | H | H | H | H | O | H | H | 2-Cl,4-CF<sub>3</sub> | 0 |
A-0618 | H | H | H | H | H | O | H | H | 2-Cl,5-CF<sub>3</sub> | 0 |
A-0619 | H | H | H | H | H | O | H | H | 2-Cl,6-CF<sub>3</sub> | 0 |
A-0620 | H | H | H | H | H | O | H | H | 3-Cl,2-CF<sub>3</sub> | 0 |
A-0621 | H | H | H | H | H | O | H | H | 3-Cl,4-CF<sub>3</sub> | 0 |
A-0622 | H | H | H | H | H | O | H | H | 3-Cl,5-CF<sub>3</sub> | 0 |
[表12]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0623 | H | H | H | H | H | O | H | H | 3-Cl,6-CF<sub>3</sub> | 0 |
A-0624 | H | H | H | H | H | O | H | H | 4-Cl,2-CF<sub>3</sub> | 0 |
A-0625 | H | H | H | H | H | O | H | H | 4-Cl,3-CF<sub>3</sub> | 0 |
A-0626 | H | H | H | H | H | O | H | H | 2-Cl,3-OMe | 0 |
A-0627 | H | H | H | H | H | O | H | H | 2-Cl,4-OMe | 0 |
A-0628 | H | H | H | H | H | O | H | H | 2-Cl,5-OMe | 0 |
A-0629 | H | H | H | H | H | O | H | H | 2-Cl,6-OMe | 0 |
A-0630 | H | H | H | H | H | O | H | H | 3-Cl,2-OMe | 0 |
A-0631 | H | H | H | H | H | O | H | H | 3-Cl,4-OMe | 0 |
A-0632 | H | H | H | H | H | O | H | H | 3-Cl,5-OMe | 0 |
A-0633 | H | H | H | H | H | O | H | H | 3-Cl,6-OMe | 0 |
A-0634 | H | H | H | H | H | O | H | H | 4-Cl,2-OMe | 0 |
A-0635 | H | H | H | H | H | O | H | H | 4-Cl,3-OMe | 0 |
A-0636 | H | H | H | H | H | O | H | H | 2,3-Me<sub>2</sub> | 0 |
A-0637 | H | H | H | H | H | O | H | H | 2,4-Me<sub>2</sub> | 0 |
A-0638 | H | H | H | H | H | O | H | H | 2,5-Me<sub>2</sub> | 0 |
A-0639 | H | H | H | H | H | O | H | H | 2,6-Me<sub>2</sub> | 0 |
A-0640 | H | H | H | H | H | O | H | H | 3,4-Me<sub>2</sub> | 0 |
A-0641 | H | H | H | H | H | O | H | H | 3,5-Me<sub>2</sub> | 0 |
A-0642 | H | H | H | H | H | O | H | H | 2-Me,3-CF<sub>3</sub> | 0 |
A-0643 | H | H | H | H | H | O | H | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-0644 | H | H | H | H | H | O | H | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-0645 | H | H | H | H | H | O | H | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-0646 | H | H | H | H | H | O | H | H | 3-Me,2-CF<sub>3</sub> | 0 |
A-0647 | H | H | H | H | H | O | H | H | 3-Me,4-CF<sub>3</sub> | 0 |
A-0648 | H | H | H | H | H | O | H | H | 3-Me,5-CF<sub>3</sub> | 0 |
A-0649 | H | H | H | H | H | O | H | H | 3-Me,6-CF<sub>3</sub> | 0 |
A-0650 | H | H | H | H | H | O | H | H | 4-Me,2-CF<sub>3</sub> | 0 |
A-0651 | H | H | H | H | H | O | H | H | 4-Me,3-CF<sub>3</sub> | 0 |
A-0652 | H | H | H | H | H | O | H | H | 2-Me,3-OMe | 0 |
A-0653 | H | H | H | H | H | O | H | H | 2-Me,4-OMe | 0 |
A-0654 | H | H | H | H | H | O | H | H | 2-Me,5-OMe | 0 |
A-0655 | H | H | H | H | H | O | H | H | 2-Me,6-OMe | 0 |
A-0656 | H | H | H | H | H | O | H | H | 3-Me,2-OMe | 0 |
A-0657 | H | H | H | H | H | O | H | H | 3-Me,4-OMe | 0 |
A-0658 | H | H | H | H | H | O | H | H | 3-Me,5-OMe | 0 |
A-0659 | H | H | H | H | H | O | H | H | 3-Me,6-OMe | 0 |
A-0660 | H | H | H | H | H | O | H | H | 4-Me,2-OMe | 0 |
A-0661 | H | H | H | H | H | O | H | H | 4-Me,3-OMe | 0 |
A-0662 | H | H | H | H | H | O | H | H | 2,3-OMe<sub>2</sub> | 0 |
A-0663 | H | H | H | H | H | O | H | H | 2,4-OMe<sub>2</sub> | 0 |
A-0664 | H | H | H | H | H | O | H | H | 2,5-OMe<sub>2</sub> | 0 |
A-0665 | H | H | H | H | H | O | H | H | 2,6-OMe<sub>2</sub> | 0 |
A-0666 | H | H | H | H | H | O | H | H | 3,4-OMe<sub>2</sub> | 0 |
A-0667 | H | H | H | H | H | O | H | H | 3,5-OMe<sub>2</sub> | 0 |
A-0668 | H | H | H | H | H | O | H | H | 2-OMe,3-CF<sub>3</sub> | 0 |
A-0669 | H | H | H | H | H | O | H | H | 2-OMe,4-CF<sub>3</sub> | 0 |
A-0670 | H | H | H | H | H | O | H | H | 2-OMe,5-CF<sub>3</sub> | 0 |
A-0671 | H | H | H | H | H | O | H | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-0672 | H | H | H | H | H | O | H | H | 3-OMe,2-CF<sub>3</sub> | 0 |
A-0673 | H | H | H | H | H | O | H | H | 3-OMe,4-CF<sub>3</sub> | 0 |
A-0674 | H | H | H | H | H | O | H | H | 3-OMe,5-CF<sub>3</sub> | 0 |
A-0675 | H | H | H | H | H | O | H | H | 3-OMe,6-CF<sub>3</sub> | 0 |
A-0676 | H | H | H | H | H | O | H | H | 4-OMe,2-CF<sub>3</sub> | 0 |
A-0677 | H | H | H | H | H | O | H | H | 4-OMe,3-CF<sub>3</sub> | 0 |
A-0678 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,3-F | 0 |
A-0679 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,4-F | 0 |
[表13]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0680 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-0681 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-0682 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,3-Me | 0 |
A-0683 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,4-Me | 0 |
A-0684 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-0685 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-0686 | H | H | H | H | H | O | H | H | 2-环丙基,3-F | 0 |
A-0687 | H | H | H | H | H | O | H | H | 2-环丙基,4-F | 0 |
A-0688 | H | H | H | H | H | O | H | H | 2-环丙基,5-F | 0 |
A-0689 | H | H | H | H | H | O | H | H | 2-环丙基,6-F | 0 |
A-0690 | H | H | H | H | H | O | H | H | 2-环丙基,3-Me | 0 |
A-0691 | H | H | H | H | H | O | H | H | 2-环丙基,4-Me | 0 |
A-0692 | H | H | H | H | H | O | H | H | 2-环丙基,5-Me | 0 |
A-0693 | H | H | H | H | H | O | H | H | 2-环丙基,6-Me | 0 |
A-0694 | H | H | H | H | H | O | H | H | 2-乙烯基,3-F | 0 |
A-0695 | H | H | H | H | H | O | H | H | 2-乙烯基,4-F | 0 |
A-0696 | H | H | H | H | H | O | H | H | 2-乙烯基,5-F | 0 |
A-0697 | H | H | H | H | H | O | H | H | 2-乙烯基,6-F | 0 |
A-0698 | H | H | H | H | H | O | H | H | 2-乙烯基,3-Me | 0 |
A-0699 | H | H | H | H | H | O | H | H | 2-乙烯基,4-Me | 0 |
A-0700 | H | H | H | H | H | O | H | H | 2-乙烯基,5-Me | 0 |
A-0701 | H | H | H | H | H | O | H | H | 2-乙烯基,6-Me | 0 |
A-0702 | H | H | H | H | H | O | H | H | 2-OEt,3-F | 0 |
A-0703 | H | H | H | H | H | O | H | H | 2-OEt,4-F | 0 |
A-0704 | H | H | H | H | H | O | H | H | 2-OEt,5-F | 0 |
A-0705 | H | H | H | H | H | O | H | H | 2-OEt,6-F | 0 |
A-0706 | H | H | H | H | H | O | H | H | 2-OEt,3-Cl | 0 |
A-0707 | H | H | H | H | H | O | H | H | 2-OEt,4-Cl | 0 |
A-0708 | H | H | H | H | H | O | H | H | 2-OEt,5-Cl | 0 |
A-0709 | H | H | H | H | H | O | H | H | 2-OEt,6-Cl | 0 |
A-0710 | H | H | H | H | H | O | H | H | 2-OEt,3-Me | 0 |
A-0711 | H | H | H | H | H | O | H | H | 2-OEt,4-Me | 0 |
A-0712 | H | H | H | H | H | O | H | H | 2-OEt,5-Me | 0 |
A-0713 | H | H | H | H | H | O | H | H | 2-OEt,6-Me | 0 |
A-0714 | H | H | H | H | H | O | H | H | 2-OPr,3-F | 0 |
A-0715 | H | H | H | H | H | O | H | H | 2-OPr,4-F | 0 |
A-0716 | H | H | H | H | H | O | H | H | 2-OPr,5-F | 0 |
A-0717 | H | H | H | H | H | O | H | H | 2-OPr,6-F | 0 |
A-0718 | H | H | H | H | H | O | H | H | 2-OPr,3-Me | 0 |
A-0719 | H | H | H | H | H | O | H | H | 2-OPr,4-Me | 0 |
A-0720 | H | H | H | H | H | O | H | H | 2-OPr,5-Me | 0 |
A-0721 | H | H | H | H | H | O | H | H | 2-OPr,6-Me | 0 |
A-0722 | H | H | H | H | H | O | H | H | 2-O(i-Pr),3-F | 0 |
A-0723 | H | H | H | H | H | O | H | H | 2-O(i-Pr),4-F | 0 |
A-0724 | H | H | H | H | H | O | H | H | 2-O(i-Pr),5-F | 0 |
A-0725 | H | H | H | H | H | O | H | H | 2-O(i-Pr),6-F | 0 |
A-0726 | H | H | H | H | H | O | H | H | 2-O(i-Pr),3-Me | 0 |
A-0727 | H | H | H | H | H | O | H | H | 2-O(i-Pr),4-Me | 0 |
A-0728 | H | H | H | H | H | O | H | H | 2-O(i-Pr),5-Me | 0 |
A-0729 | H | H | H | H | H | O | H | H | 2-O(i-Pr),6-Me | 0 |
A-0730 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,3-F | 0 |
A-0731 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,4-F | 0 |
A-0732 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,5-F | 0 |
A-0733 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,6-F | 0 |
A-0734 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,3-Me | 0 |
A-0735 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,4-Me | 0 |
A-0736 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,5-Me | 0 |
[表14]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0737 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,6-Me | 0 |
A-0738 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,3-F | 0 |
A-0739 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,4-F | 0 |
A-0740 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-0741 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-0742 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,3-Me | 0 |
A-0743 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,4-Me | 0 |
A-0744 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-0745 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-0746 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),3-F | 0 |
A-0747 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),4-F | 0 |
A-0748 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),5-F | 0 |
A-0749 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),6-F | 0 |
A-0750 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),3-Me | 0 |
A-0751 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),4-Me | 0 |
A-0752 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),5-Me | 0 |
A-0753 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),6-Me | 0 |
A-0754 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),3-F | 0 |
A-0755 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),4-F | 0 |
A-0756 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),5-F | 0 |
A-0757 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),6-F | 0 |
A-0758 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),3-Me | 0 |
A-0759 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),4-Me | 0 |
A-0760 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),5-Me | 0 |
A-0761 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),6-Me | 0 |
A-0762 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),3-F | 0 |
A-0763 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),4-F | 0 |
A-0764 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),5-F | 0 |
A-0765 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),6-F | 0 |
A-0766 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),3-Me | 0 |
A-0767 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),4-Me | 0 |
A-0768 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),5-Me | 0 |
A-0769 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),6-Me | 0 |
A-0770 | H | H | H | H | H | O | H | H | 2-SMe,3-F | 0 |
A-0771 | H | H | H | H | H | O | H | H | 2-SMe,4-F | 0 |
A-0772 | H | H | H | H | H | O | H | H | 2-SMe,5-F | 0 |
A-0773 | H | H | H | H | H | O | H | H | 2-SMe,6-F | 0 |
A-0774 | H | H | H | H | H | O | H | H | 2-SMe,3-Me | 0 |
A-0775 | H | H | H | H | H | O | H | H | 2-SMe,4-Me | 0 |
A-0776 | H | H | H | H | H | O | H | H | 2-SMe,5-Me | 0 |
A-0777 | H | H | H | H | H | O | H | H | 2-SMe,6-Me | 0 |
A-0778 | H | H | H | H | H | O | H | H | 2-SEt,3-F | 0 |
A-0779 | H | H | H | H | H | O | H | H | 2-SEt,4-F | 0 |
A-0780 | H | H | H | H | H | O | H | H | 2-SEt,5-F | 0 |
A-0781 | H | H | H | H | H | O | H | H | 2-SEt,6-F | 0 |
A-0782 | H | H | H | H | H | O | H | H | 2-SEt,3-Me | 0 |
A-0783 | H | H | H | H | H | O | H | H | 2-SEt,4-Me | 0 |
A-0784 | H | H | H | H | H | O | H | H | 2-SEt,5-Me | 0 |
A-0785 | H | H | H | H | H | O | H | H | 2-SEt,6-Me | 0 |
A-0786 | H | H | H | H | H | O | H | H | 2-S(=O)Me,3-F | 0 |
A-0787 | H | H | H | H | H | O | H | H | 2-S(=O)Me,4-F | 0 |
A-0788 | H | H | H | H | H | O | H | H | 2-S(=O)Me,5-F | 0 |
A-0789 | H | H | H | H | H | O | H | H | 2-S(=O)Me,6-F | 0 |
A-0790 | H | H | H | H | H | O | H | H | 3-S(=O)Me,2-F | 0 |
A-0791 | H | H | H | H | H | O | H | H | 3-S(=O)Me,4-F | 0 |
A-0792 | H | H | H | H | H | O | H | H | 3-S(=O)Me,5-F | 0 |
A-0793 | H | H | H | H | H | O | H | H | 3-S(=O)Me,6-F | 0 |
[表15]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0794 | H | H | H | H | H | O | H | H | 2-S(=O)Me,3-Me | 0 |
A-0795 | H | H | H | H | H | O | H | H | 2-S(=O)Me,4-Me | 0 |
A-0796 | H | H | H | H | H | O | H | H | 2-S(=O)Me,5-Me | 0 |
A-0797 | H | H | H | H | H | O | H | H | 2-S(=O)Me,6-Me | 0 |
A-0798 | H | H | H | H | H | O | H | H | 3-S(=O)Me,2-Me | 0 |
A-0799 | H | H | H | H | H | O | H | H | 3-S(=O)Me,4-Me | 0 |
A-0800 | H | H | H | H | H | O | H | H | 3-S(=O)Me,5-Me | 0 |
A-0801 | H | H | H | H | H | O | H | H | 3-S(=O)Me,6-Me | 0 |
A-0802 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,3-F | 0 |
A-0803 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,4-F | 0 |
A-0804 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-0805 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-0806 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,3-Me | 0 |
A-0807 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,4-Me | 0 |
A-0808 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-0809 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-0810 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,3-F | 0 |
A-0811 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,4-F | 0 |
A-0812 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-0813 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-0814 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,3-Me | 0 |
A-0815 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,4-Me | 0 |
A-0816 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-0817 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-0818 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,3-F | 0 |
A-0819 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,4-F | 0 |
A-0820 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-0821 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-0822 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,3-Me | 0 |
A-0823 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,4-Me | 0 |
A-0824 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-0825 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-0826 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-F | 0 |
A-0827 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-F | 0 |
A-0828 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-0829 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-0830 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-Me | 0 |
A-0831 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-Me | 0 |
A-0832 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-0833 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-0834 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),3-F | 0 |
A-0835 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),4-F | 0 |
A-0836 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),5-F | 0 |
A-0837 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),6-F | 0 |
A-0838 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),3-Me | 0 |
A-0839 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),4-Me | 0 |
A-0840 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),5-Me | 0 |
A-0841 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),6-Me | 0 |
A-0842 | H | H | H | H | H | O | H | H | 2-C(=O)Me,3-F | 0 |
A-0843 | H | H | H | H | H | O | H | H | 2-C(=O)Me,4-F | 0 |
A-0844 | H | H | H | H | H | O | H | H | 2-C(=O)Me,5-F | 0 |
A-0845 | H | H | H | H | H | O | H | H | 2-C(=O)Me,6-F | 0 |
A-0846 | H | H | H | H | H | O | H | H | 2-C(=O)Me,3-Me | 0 |
A-0847 | H | H | H | H | H | O | H | H | 2-C(=O)Me,4-Me | 0 |
A-0848 | H | H | H | H | H | O | H | H | 2-C(=O)Me,5-Me | 0 |
A-0849 | H | H | H | H | H | O | H | H | 2-C(=O)Me,6-Me | 0 |
A-0850 | H | H | H | H | H | O | H | H | 3-C(=O)Me,2-F | 0 |
[表16]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0851 | H | H | H | H | H | O | H | H | 3-C(=O)Me,4-F | 0 |
A-0852 | H | H | H | H | H | O | H | H | 3-C(=O)Me,5-F | 0 |
A-0853 | H | H | H | H | H | O | H | H | 3-C(=O)Me,6-F | 0 |
A-0854 | H | H | H | H | H | O | H | H | 3-C(=O)Me,2-Me | 0 |
A-0855 | H | H | H | H | H | O | H | H | 3-C(=O)Me,4-Me | 0 |
A-0856 | H | H | H | H | H | O | H | H | 3-C(=O)Me,5-Me | 0 |
A-0857 | H | H | H | H | H | O | H | H | 3-C(=O)Me,6-Me | 0 |
A-0858 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,3-F | 0 |
A-0859 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,4-F | 0 |
A-0860 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,5-F | 0 |
A-0861 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,6-F | 0 |
A-0862 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,3-Me | 0 |
A-0863 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,4-Me | 0 |
A-0864 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,5-Me | 0 |
A-0865 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,6-Me | 0 |
A-0866 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,3-F | 0 |
A-0867 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,4-F | 0 |
A-0868 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,5-F | 0 |
A-0869 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,6-F | 0 |
A-0870 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,3-Me | 0 |
A-0871 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,4-Me | 0 |
A-0872 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,5-Me | 0 |
A-0873 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,6-Me | 0 |
A-0874 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,3-F | 0 |
A-0875 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,4-F | 0 |
A-0876 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,5-F | 0 |
A-0877 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,6-F | 0 |
A-0878 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,3-Me | 0 |
A-0879 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,4-Me | 0 |
A-0880 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,5-Me | 0 |
A-0881 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,6-Me | 0 |
A-0882 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,3-F | 0 |
A-0883 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,4-F | 0 |
A-0884 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,5-F | 0 |
A-0885 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,6-F | 0 |
A-0886 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,3-Me | 0 |
A-0887 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,4-Me | 0 |
A-0888 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,5-Me | 0 |
A-0889 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,6-Me | 0 |
A-0890 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,3-F | 0 |
A-0891 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,4-F | 0 |
A-0892 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,5-F | 0 |
A-0893 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,6-F | 0 |
A-0894 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,3-Me | 0 |
A-0895 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,4-Me | 0 |
A-0896 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,5-Me | 0 |
A-0897 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,6-Me | 0 |
A-0898 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,3-F | 0 |
A-0899 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,4-F | 0 |
A-0900 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-0901 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-0902 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,3-Me | 0 |
A-0903 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,4-Me | 0 |
A-0904 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-0905 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-0906 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-F | 0 |
A-0907 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
[表17]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0908 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-0909 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-0910 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-Me | 0 |
A-0911 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-0912 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-0913 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-0914 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-F | 0 |
A-0915 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-F | 0 |
A-0916 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-0917 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-0918 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-Me | 0 |
A-0919 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-Me | 0 |
A-0920 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-0921 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-0922 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,3-F | 0 |
A-0923 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,4-F | 0 |
A-0924 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-0925 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-0926 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,3-Me | 0 |
A-0927 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,4-Me | 0 |
A-0928 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-0929 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-0930 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-F | 0 |
A-0931 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-F | 0 |
A-0932 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-0933 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-0934 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-Me | 0 |
A-0935 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-Me | 0 |
A-0936 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-0937 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-0938 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-F | 0 |
A-0939 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-F | 0 |
A-0940 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-0941 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-0942 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-Me | 0 |
A-0943 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-Me | 0 |
A-0944 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-0945 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-0946 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-F | 0 |
A-0947 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-F | 0 |
A-0948 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-F | 0 |
A-0949 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-F | 0 |
A-0950 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-Me | 0 |
A-0951 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-Me | 0 |
A-0952 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-Me | 0 |
A-0953 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-Me | 0 |
A-0954 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),3-F | 0 |
A-0955 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),4-F | 0 |
A-0956 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),5-F | 0 |
A-0957 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),6-F | 0 |
A-0958 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),3-Me | 0 |
A-0959 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),4-Me | 0 |
A-0960 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),5-Me | 0 |
A-0961 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),6-Me | 0 |
A-0962 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,3-F | 0 |
A-0963 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,4-F | 0 |
A-0964 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,5-F | 0 |
[表18]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-0965 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,6-F | 0 |
A-0966 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,3-Me | 0 |
A-0967 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,4-Me | 0 |
A-0968 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,5-Me | 0 |
A-0969 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,6-Me | 0 |
A-0970 | H | H | H | H | H | O | H | H | 2-NHMe,3-F | 0 |
A-0971 | H | H | H | H | H | O | H | H | 2-NHMe,4-F | 0 |
A-0972 | H | H | H | H | H | O | H | H | 2-NHMe,5-F | 0 |
A-0973 | H | H | H | H | H | O | H | H | 2-NHMe,6-F | 0 |
A-0974 | H | H | H | H | H | O | H | H | 2-NHMe,3-Me | 0 |
A-0975 | H | H | H | H | H | O | H | H | 2-NHMe,4-Me | 0 |
A-0976 | H | H | H | H | H | O | H | H | 2-NHMe,5-Me | 0 |
A-0977 | H | H | H | H | H | O | H | H | 2-NHMe,6-Me | 0 |
A-0978 | H | H | H | H | H | O | H | H | 2-NHEt,3-F | 0 |
A-0979 | H | H | H | H | H | O | H | H | 2-NHEt,4-F | 0 |
A-0980 | H | H | H | H | H | O | H | H | 2-NHEt,5-F | 0 |
A-0981 | H | H | H | H | H | O | H | H | 2-NHEt,6-F | 0 |
A-0982 | H | H | H | H | H | O | H | H | 2-NHEt,3-Me | 0 |
A-0983 | H | H | H | H | H | O | H | H | 2-NHEt,4-Me | 0 |
A-0984 | H | H | H | H | H | O | H | H | 2-NHEt,5-Me | 0 |
A-0985 | H | H | H | H | H | O | H | H | 2-NHEt,6-Me | 0 |
A-0986 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,3-F | 0 |
A-0987 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,4-F | 0 |
A-0988 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-0989 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-0990 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,3-Me | 0 |
A-0991 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,4-Me | 0 |
A-0992 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-0993 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-0994 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,3-F | 0 |
A-0995 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,4-F | 0 |
A-0996 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,5-F | 0 |
A-0997 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,6-F | 0 |
A-0998 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,3-Me | 0 |
A-0999 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,4-Me | 0 |
A-1000 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,5-Me | 0 |
A-1001 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,6-Me | 0 |
A-1002 | H | H | H | H | H | O | H | H | 2-CHO,3-F | 0 |
A-1003 | H | H | H | H | H | O | H | H | 2-CHO,4-F | 0 |
A-1004 | H | H | H | H | H | O | H | H | 2-CHO,5-F | 0 |
A-1005 | H | H | H | H | H | O | H | H | 2-CHO,6-F | 0 |
A-1006 | H | H | H | H | H | O | H | H | 2-CHO,3-Me | 0 |
A-1007 | H | H | H | H | H | O | H | H | 2-CHO,4-Me | 0 |
A-1008 | H | H | H | H | H | O | H | H | 2-CHO,5-Me | 0 |
A-1009 | H | H | H | H | H | O | H | H | 2-CHO,6-Me | 0 |
A-1010 | H | H | H | H | H | O | H | H | 2-C(=O)OH,3-F | 0 |
A-1011 | H | H | H | H | H | O | H | H | 2-C(=O)OH,4-F | 0 |
A-1012 | H | H | H | H | H | O | H | H | 2-C(=O)OH,5-F | 0 |
A-1013 | H | H | H | H | H | O | H | H | 2-C(=O)OH,6-F | 0 |
A-1014 | H | H | H | H | H | O | H | H | 2-C(=O)OH,3-Me | 0 |
A-1015 | H | H | H | H | H | O | H | H | 2-C(=O)OH,4-Me | 0 |
A-1016 | H | H | H | H | H | O | H | H | 2-C(=O)OH,5-Me | 0 |
A-1017 | H | H | H | H | H | O | H | H | 2-C(=O)OH,6-Me | 0 |
A-1018 | H | H | H | H | H | O | H | H | 2-(1,3-二氧杂环戊烷-2-基),3-F | 0 |
A-1019 | H | H | H | H | H | O | H | H | 2-(1,3-二氧杂环戊烷-2-基),4-F | 0 |
A-1020 | H | H | H | H | H | O | H | H | 2-(1,3-二氧杂环戊烷-2-基),5-F | 0 |
A-1021 | H | H | H | H | H | O | H | H | 2-(1,3-二氧杂环戊烷-2-基),6-F | 0 |
[表19]
[表20]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1079 | H | H | H | H | H | O | H | H | 2-CN,4-OMe | 0 |
A-1080 | H | H | H | H | H | O | H | H | 2-CN,5-OMe | 0 |
A-1081 | H | H | H | H | H | O | H | H | 2-CN,6-OMe | 0 |
A-1082 | H | H | H | H | H | O | H | H | 3-CN,2-F | 0 |
A-1083 | H | H | H | H | H | O | H | H | 3-CN,4-F | 0 |
A-1084 | H | H | H | H | H | O | H | H | 3-CN,5-F | 0 |
A-1085 | H | H | H | H | H | O | H | H | 3-CN,6-F | 0 |
A-1086 | H | H | H | H | H | O | H | H | 3-CN,2-Cl | 0 |
A-1087 | H | H | H | H | H | O | H | H | 3-CN,4-Cl | 0 |
A-1088 | H | H | H | H | H | O | H | H | 3-CN,5-Cl | 0 |
A-1089 | H | H | H | H | H | O | H | H | 3-CN,6-Cl | 0 |
A-1090 | H | H | H | H | H | O | H | H | 3-CN,2-Me | 0 |
A-1091 | H | H | H | H | H | O | H | H | 3-CN,4-Me | 0 |
A-1092 | H | H | H | H | H | O | H | H | 3-CN,5-Me | 0 |
A-1093 | H | H | H | H | H | O | H | H | 3-CN,6-Me | 0 |
A-1094 | H | H | H | H | H | O | H | H | 3-CN,2-OMe | 0 |
A-1095 | H | H | H | H | H | O | H | H | 3-CN,4-OMe | 0 |
A-1096 | H | H | H | H | H | O | H | H | 3-CN,5-OMe | 0 |
A-1097 | H | H | H | H | H | O | H | H | 3-CN,6-OMe | 0 |
A-1098 | H | H | H | H | H | O | H | H | 4-CN,2-F | 0 |
A-1099 | H | H | H | H | H | O | H | H | 4-CN,3-F | 0 |
A-1100 | H | H | H | H | H | O | H | H | 4-CN,2-Cl | 0 |
A-1101 | H | H | H | H | H | O | H | H | 4-CN,3-Cl | 0 |
A-1102 | H | H | H | H | H | O | H | H | 4-CN,2-Me | 0 |
A-1103 | H | H | H | H | H | O | H | H | 4-CN,3-Me | 0 |
A-1104 | H | H | H | H | H | O | H | H | 4-CN,2-OMe | 0 |
A-1105 | H | H | H | H | H | O | H | H | 4-CN,3-OMe | 0 |
A-1106 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,3-F | 0 |
A-1107 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,4-F | 0 |
A-1108 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,5-F | 0 |
A-1109 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,6-F | 0 |
A-1110 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,3-Me | 0 |
A-1111 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-1112 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-1113 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-1114 | H | H | H | H | H | O | H | H | 2-Me,3,4-F<sub>2</sub> | 0 |
A-1115 | H | H | H | H | H | O | H | H | 2-Me,3,5-F<sub>2</sub> | 0 |
A-1116 | H | H | H | H | H | O | H | H | 2-Me,3,6-F<sub>2</sub> | 0 |
A-1117 | H | H | H | H | H | O | H | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-1118 | H | H | H | H | H | O | H | H | 2-OMe,3,4-F<sub>2</sub> | 0 |
A-1119 | H | H | H | H | H | O | H | H | 2-OMe,3,5-F<sub>2</sub> | 0 |
A-1120 | H | H | H | H | H | O | H | H | 2-OMe,3,6-F<sub>2</sub> | 0 |
A-1121 | H | H | H | H | H | O | H | H | 2-OMe,4,5-F<sub>2</sub> | 0 |
A-1122 | H | H | H | H | H | O | H | H | 2-(CH<sub>2</sub>)<sub>3</sub>-3 | 0 |
A-1123 | H | H | H | H | H | O | H | H | 2-(CH<sub>2</sub>)<sub>4</sub>-3 | 0 |
A-1124 | H | H | H | H | H | O | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>)-3 | 0 |
A-1125 | H | H | H | H | H | O | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-3 | 0 |
A-1126 | H | H | H | H | H | O | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>O)-3 | 0 |
A-1127 | H | H | H | H | H | O | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-3 | 0 |
A-1128 | H | H | H | H | H | O | H | H | 3-(CH<sub>2</sub>)<sub>3</sub>-4 | 0 |
A-1129 | H | H | H | H | H | O | H | H | 3-(CH<sub>2</sub>)<sub>4</sub>-4 | 0 |
A-1130 | H | H | H | H | H | O | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>)-4 | 0 |
A-1131 | H | H | H | H | H | O | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-4 | 0 |
A-1132 | H | H | H | H | H | O | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>O)-4 | 0 |
A-1133 | H | H | H | H | H | O | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-4 | 0 |
A-1134 | H | H | H | H | H | O | H | H | 2-(OCH<sub>2</sub>O)-3 | 0 |
A-1135 | H | H | H | H | H | O | H | H | 3-(OCH<sub>2</sub>O)-4 | 0 |
[表21]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1136 | H | H | H | H | H | O | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>O)-3 | 0 |
A-1137 | H | H | H | H | H | O | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>O)-4 | 0 |
A-1138 | H | H | H | H | H | O | H | H | 2-(OCF<sub>2</sub>O)-3 | 0 |
A-1139 | H | H | H | H | H | O | H | H | 3-(OCF<sub>2</sub>O)-4 | 0 |
A-1140 | H | H | H | H | H | O | H | H | 2-Me,6-Et | 0 |
A-1141 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OTBS | 0 |
A-1142 | H | H | H | H | H | O | H | H | 2-环丙基,3-OMe | 0 |
A-1143 | H | H | H | H | H | O | H | H | 2-环丙基,4-OMe | 0 |
A-1144 | H | H | H | H | H | O | H | H | 2-环丙基,5-OMe | 0 |
A-1145 | H | H | H | H | H | O | H | H | 2-环丙基,6-OMe | 0 |
A-1146 | H | H | H | H | H | O | H | H | 2-Me,3-OMe,6-Me | 0 |
A-1147 | H | H | H | H | H | O | H | H | 2-Me,4-OMe,6-Me | 0 |
A-1148 | H | H | H | H | H | O | H | H | 2-OMe,3-Me,6-Me | 0 |
A-1149 | H | H | H | H | H | O | H | H | 2-OMe,5-Me,6-Me | 0 |
A-1150 | H | H | H | H | H | O | H | H | 2-OMe,3-F,6-Me | 0 |
A-1151 | H | H | H | H | H | O | H | H | 2-OMe,5-F,6-Me | 0 |
A-1152 | H | H | H | H | H | O | H | H | 2-OMe,5-Me,6-F | 0 |
A-1153 | H | H | H | H | H | O | H | H | 2-Cl,3-Me,6-F | 0 |
A-1154 | H | H | H | H | H | O | H | H | 2-Cl,5-Me,6-F | 0 |
A-1155 | H | H | H | H | H | O | H | H | 2-Cl,3-OMe,6-F | 0 |
A-1156 | H | H | H | H | H | O | H | H | 2-Cl,5-OMe,6-F | 0 |
A-1157 | H | H | H | H | H | O | H | H | 2-Me,5-Et | 0 |
A-1158 | H | H | H | H | H | O | H | H | 2,6-Et<sub>2</sub> | 0 |
A-1159 | H | H | H | H | H | O | H | H | 2-Et,6-F | 0 |
A-1160 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-1161 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-1162 | H | H | H | H | H | O | H | H | 2-OMe,5-CH=NOMe | 0 |
A-1163 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-1164 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-CF<sub>3</sub> | 0 |
A-1165 | H | H | H | H | H | O | H | H | 2-CHCl<sub>2</sub> | 0 |
A-1166 | H | H | F | H | H | O | H | H | 2-Me | 0 |
A-1167 | H | H | H | H | H | O | CH<sub>3</sub> | H | H | 0 |
A-1168 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-F | 0 |
A-1169 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Cl | 0 |
A-1170 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Br | 0 |
A-1171 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OH | 0 |
A-1172 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Me | 0 |
A-1173 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Et | 0 |
A-1174 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Pr | 0 |
A-1175 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CF<sub>3</sub> | 0 |
A-1176 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-1177 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-1178 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-1179 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-环丙基 | 0 |
A-1180 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-环丁基 | 0 |
A-1181 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-环戊基 | 0 |
A-1182 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-乙烯基 | 0 |
A-1183 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-烯丙基 | 0 |
A-1184 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-1185 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(三氟乙烯基) | 0 |
A-1186 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OMe | 0 |
A-1187 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OEt | 0 |
A-1188 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OPr | 0 |
A-1189 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-O(i-Pr) | 0 |
A-1190 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OCF<sub>3</sub> | 0 |
A-1191 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OCHF<sub>2</sub> | 0 |
A-1192 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(环丙基氧基) | 0 |
[表22]
[表23]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1250 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2,6-Me<sub>2</sub> | 0 |
A-1251 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-1252 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-1253 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-1254 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Me,4-OMe | 0 |
A-1255 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Me,5-OMe | 0 |
A-1256 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Me,6-OMe | 0 |
A-1257 | H | H | H | H | H | O | CH<sub>3</sub> | H | 3-Me,6-OMe | 0 |
A-1258 | H | H | H | H | H | O | CH<sub>3</sub> | H | 4-Me,2-OMe | 0 |
A-1259 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2,5-OMe<sub>2</sub> | 0 |
A-1260 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2,6-OMe<sub>2</sub> | 0 |
A-1261 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-1262 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-1263 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-1264 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-1265 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-1266 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-环丙基,5-F | 0 |
A-1267 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-环丙基,6-F | 0 |
A-1268 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-环丙基,5-Me | 0 |
A-1269 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-环丙基,6-Me | 0 |
A-1270 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-乙烯基,6-F | 0 |
A-1271 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-乙烯基,6-Me | 0 |
A-1272 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OEt,5-F | 0 |
A-1273 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OEt,6-F | 0 |
A-1274 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OEt,5-Cl | 0 |
A-1275 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OEt,6-Cl | 0 |
A-1276 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OEt,5-Me | 0 |
A-1277 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OEt,6-Me | 0 |
A-1278 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-1279 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-1280 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-1281 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-1282 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-1283 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-1284 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-1285 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-1286 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-1287 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-1288 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-1289 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-1290 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-1291 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-1292 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-1293 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-1294 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-1295 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-1296 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-1297 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-1298 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-1299 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-1300 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-1301 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-1302 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-1303 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-1304 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-1305 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-1306 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
[表24]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1307 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-1308 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-1309 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-1310 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-1311 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-1312 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-1313 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-1314 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-1315 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-1316 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-1317 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-1318 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-1319 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-1320 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-1321 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-1322 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-1323 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-1324 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-1325 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-1326 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-1327 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-1328 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-1329 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-1330 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-1331 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-1332 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-1333 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-1334 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-1335 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-1336 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-1337 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-1338 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-1339 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-1340 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-1341 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-1342 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-1343 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-1344 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-1345 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-1346 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-1347 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-1348 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-1349 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-1350 | H | H | H | H | H | O | CH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-1351 | H | H | H | H | H | O | CH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-1352 | H | H | H | H | H | O | CH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-1353 | H | H | H | H | H | O | CH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-1354 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-1355 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-1356 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-1357 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-1358 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-1359 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-1360 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-1361 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-1362 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-1363 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Me,5-Et | 0 |
[表25]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1364 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-1365 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-1366 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-1367 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-1368 | H | H | H | H | H | O | CH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-1369 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | H | 0 |
A-1370 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-F | 0 |
A-1371 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-Cl | 0 |
A-1372 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-Br | 0 |
A-1373 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OH | 0 |
A-1374 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me | 0 |
A-1375 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-Et | 0 |
A-1376 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-Pr | 0 |
A-1377 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CF<sub>3</sub> | 0 |
A-1378 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-1379 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-1380 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-1381 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基 | 0 |
A-1382 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-环丁基 | 0 |
A-1383 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-环戊基 | 0 |
A-1384 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-乙烯基 | 0 |
A-1385 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-烯丙基 | 0 |
A-1386 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-1387 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(三氟乙烯基) | 0 |
A-1388 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OMe | 0 |
A-1389 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt | 0 |
A-1390 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OPr | 0 |
A-1391 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-O(i-Pr) | 0 |
A-1392 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OCF<sub>3</sub> | 0 |
A-1393 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub> | 0 |
A-1394 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基) | 0 |
A-1395 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丁基氧基) | 0 |
A-1396 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环戊基氧基) | 0 |
A-1397 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-1398 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环氧乙烷-2-基) | 0 |
A-1399 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe | 0 |
A-1400 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 3-SMe | 0 |
A-1401 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me | 0 |
A-1402 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 3-S(=O)Me | 0 |
A-1403 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-1404 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-1405 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub> | 0 |
A-1406 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 3-SCF<sub>3</sub> | 0 |
A-1407 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 3-S(=O)CF<sub>3</sub> | 0 |
A-1408 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-1409 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基) | 0 |
A-1410 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基亚磺酰基) | 0 |
A-1411 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基磺酰基) | 0 |
A-1412 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me | 0 |
A-1413 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
A-1414 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
A-1415 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH | 0 |
A-1416 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
A-1417 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
A-1418 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
A-1419 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
A-1420 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
[表26]
[表27]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1478 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,5-Me | 0 |
A-1479 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,6-Me | 0 |
A-1480 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-1481 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-1482 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-1483 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-1484 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-1485 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-1486 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-1487 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-1488 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-1489 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-1490 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-1491 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-1492 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-1493 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-1494 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-1495 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-1496 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-1497 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-1498 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-1499 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-1500 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-1501 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-1502 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-1503 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-1504 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-1505 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-1506 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-1507 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-1508 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-1509 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-1510 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-1511 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-1512 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-1513 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-1514 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-1515 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-1516 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-1517 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-1518 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-1519 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-1520 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-1521 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-1522 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-1523 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-1524 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-1525 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-1526 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-1527 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-1528 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-1529 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-1530 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-1531 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-1532 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-1533 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-1534 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
[表28]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1535 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-1536 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-1537 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-1538 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-1539 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-1540 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-1541 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-1542 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-1543 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-1544 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-1545 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-1546 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-1547 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-1548 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-1549 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-1550 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-1551 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-1552 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-1553 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-1554 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-1555 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-1556 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-1557 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-1558 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-1559 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-1560 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-1561 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-1562 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-1563 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-1564 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-1565 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-1566 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-1567 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-1568 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-1569 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-1570 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-1571 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | H | 0 |
A-1572 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-F | 0 |
A-1573 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Cl | 0 |
A-1574 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Br | 0 |
A-1575 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OH | 0 |
A-1576 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me | 0 |
A-1577 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Et | 0 |
A-1578 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Pr | 0 |
A-1579 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CF<sub>3</sub> | 0 |
A-1580 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-1581 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-1582 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-1583 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基 | 0 |
A-1584 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-环丁基 | 0 |
A-1585 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-环戊基 | 0 |
A-1586 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-乙烯基 | 0 |
A-1587 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-烯丙基 | 0 |
A-1588 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-1589 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-(三氟乙烯基) | 0 |
A-1590 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OMe | 0 |
A-1591 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt | 0 |
[表29]
[表30]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1649 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Cl,6-OMe | 0 |
A-1650 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 3-Cl,6-OMe | 0 |
A-1651 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 4-Cl,2-OMe | 0 |
A-1652 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2,4-Me<sub>2</sub> | 0 |
A-1653 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2,5-Me<sub>2</sub> | 0 |
A-1654 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2,6-Me<sub>2</sub> | 0 |
A-1655 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-1656 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-1657 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-1658 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,4-OMe | 0 |
A-1659 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,5-OMe | 0 |
A-1660 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,6-OMe | 0 |
A-1661 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 3-Me,6-OMe | 0 |
A-1662 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 4-Me,2-OMe | 0 |
A-1663 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2,5-OMe<sub>2</sub> | 0 |
A-1664 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2,6-OMe<sub>2</sub> | 0 |
A-1665 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-1666 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-1667 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-1668 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-1669 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-1670 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,5-F | 0 |
A-1671 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-F | 0 |
A-1672 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,5-Me | 0 |
A-1673 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-Me | 0 |
A-1674 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-乙烯基,6-F | 0 |
A-1675 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-乙烯基,6-Me | 0 |
A-1676 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,5-F | 0 |
A-1677 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,6-F | 0 |
A-1678 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,5-Cl | 0 |
A-1679 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,6-Cl | 0 |
A-1680 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,5-Me | 0 |
A-1681 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,6-Me | 0 |
A-1682 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-1683 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-1684 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-1685 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-1686 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-1687 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-1688 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-1689 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-1690 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-1691 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-1692 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-1693 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-1694 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-1695 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-1696 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-1697 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-1698 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-1699 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-1700 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-1701 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-1702 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-1703 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-1704 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-1705 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
[表31]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1706 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-1707 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-1708 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-1709 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-1710 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-1711 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-1712 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-1713 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-1714 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-1715 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-1716 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-1717 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-1718 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-1719 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-1720 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-1721 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-1722 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-1723 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-1724 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-1725 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-1726 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-1727 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-1728 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-1729 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-1730 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-1731 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-1732 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-1733 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-1734 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-1735 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-1736 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-1737 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-1738 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-1739 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-1740 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-1741 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-1742 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-1743 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-1744 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-1745 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-1746 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-1747 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-1748 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-1749 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-1750 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-1751 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-1752 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-1753 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-1754 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-1755 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-1756 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-1757 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-1758 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-1759 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-1760 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-1761 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-1762 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
[表32]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1763 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-1764 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-1765 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-1766 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-1767 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-1768 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-1769 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-1770 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-1771 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-1772 | H | H | H | H | H | O | CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-1773 | H | H | H | H | H | O | 环丙基 | H | H | 0 |
A-1774 | H | H | H | H | H | O | 环丙基 | H | 2-F | 0 |
A-1775 | H | H | H | H | H | O | 环丙基 | H | 2-Cl | 0 |
A-1776 | H | H | H | H | H | O | 环丙基 | H | 2-Br | 0 |
A-1777 | H | H | H | H | H | O | 环丙基 | H | 2-OH | 0 |
A-1778 | H | H | H | H | H | O | 环丙基 | H | 2-Me | 0 |
A-1779 | H | H | H | H | H | O | 环丙基 | H | 2-Et | 0 |
A-1780 | H | H | H | H | H | O | 环丙基 | H | 2-Pr | 0 |
A-1781 | H | H | H | H | H | O | 环丙基 | H | 2-CF<sub>3</sub> | 0 |
A-1782 | H | H | H | H | H | O | 环丙基 | H | 2-CHF<sub>2</sub> | 0 |
A-1783 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>F | 0 |
A-1784 | H | H | H | H | H | O | 环丙基 | H | 2-CF<sub>2</sub>Cl | 0 |
A-1785 | H | H | H | H | H | O | 环丙基 | H | 2-环丙基 | 0 |
A-1786 | H | H | H | H | H | O | 环丙基 | H | 2-环丁基 | 0 |
A-1787 | H | H | H | H | H | O | 环丙基 | H | 2-环戊基 | 0 |
A-1788 | H | H | H | H | H | O | 环丙基 | H | 2-乙烯基 | 0 |
A-1789 | H | H | H | H | H | O | 环丙基 | H | 2-烯丙基 | 0 |
A-1790 | H | H | H | H | H | O | 环丙基 | H | 2-(丙-1-烯-1-基) | 0 |
A-1791 | H | H | H | H | H | O | 环丙基 | H | 2-(三氟乙烯基) | 0 |
A-1792 | H | H | H | H | H | O | 环丙基 | H | 2-OMe | 0 |
A-1793 | H | H | H | H | H | O | 环丙基 | H | 2-OEt | 0 |
A-1794 | H | H | H | H | H | O | 环丙基 | H | 2-OPr | 0 |
A-1795 | H | H | H | H | H | O | 环丙基 | H | 2-O(i-Pr) | 0 |
A-1796 | H | H | H | H | H | O | 环丙基 | H | 2-OCF<sub>3</sub> | 0 |
A-1797 | H | H | H | H | H | O | 环丙基 | H | 2-OCHF<sub>2</sub> | 0 |
A-1798 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基氧基) | 0 |
A-1799 | H | H | H | H | H | O | 环丙基 | H | 2-(环丁基氧基) | 0 |
A-1800 | H | H | H | H | H | O | 环丙基 | H | 2-(环戊基氧基) | 0 |
A-1801 | H | H | H | H | H | O | 环丙基 | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-1802 | H | H | H | H | H | O | 环丙基 | H | 2-(环氧乙烷-2-基) | 0 |
A-1803 | H | H | H | H | H | O | 环丙基 | H | 2-SMe | 0 |
A-1804 | H | H | H | H | H | O | 环丙基 | H | 3-SMe | 0 |
A-1805 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)Me | 0 |
A-1806 | H | H | H | H | H | O | 环丙基 | H | 3-S(=O)Me | 0 |
A-1807 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-1808 | H | H | H | H | H | O | 环丙基 | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-1809 | H | H | H | H | H | O | 环丙基 | H | 2-SCF<sub>3</sub> | 0 |
A-1810 | H | H | H | H | H | O | 环丙基 | H | 3-SCF<sub>3</sub> | 0 |
A-1811 | H | H | H | H | H | O | 环丙基 | H | 3-S(=O)CF<sub>3</sub> | 0 |
A-1812 | H | H | H | H | H | O | 环丙基 | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-1813 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基硫基) | 0 |
A-1814 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基亚磺酰基) | 0 |
A-1815 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基磺酰基) | 0 |
A-1816 | H | H | H | H | H | O | 环丙基 | H | 2-C(=O)Me | 0 |
A-1817 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
A-1818 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
A-1819 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OH | 0 |
[表33]
[表34]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1877 | H | H | H | H | H | O | 环丙基 | H | 2-乙烯基,6-Me | 0 |
A-1878 | H | H | H | H | H | O | 环丙基 | H | 2-OEt,5-F | 0 |
A-1879 | H | H | H | H | H | O | 环丙基 | H | 2-OEt,6-F | 0 |
A-1880 | H | H | H | H | H | O | 环丙基 | H | 2-OEt,5-Cl | 0 |
A-1881 | H | H | H | H | H | O | 环丙基 | H | 2-OEt,6-Cl | 0 |
A-1882 | H | H | H | H | H | O | 环丙基 | H | 2-OEt,5-Me | 0 |
A-1883 | H | H | H | H | H | O | 环丙基 | H | 2-OEt,6-Me | 0 |
A-1884 | H | H | H | H | H | O | 环丙基 | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-1885 | H | H | H | H | H | O | 环丙基 | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-1886 | H | H | H | H | H | O | 环丙基 | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-1887 | H | H | H | H | H | O | 环丙基 | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-1888 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基氧基),5-F | 0 |
A-1889 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基氧基),6-F | 0 |
A-1890 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基氧基),5-Me | 0 |
A-1891 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基氧基),6-Me | 0 |
A-1892 | H | H | H | H | H | O | 环丙基 | H | 2-SMe,5-F | 0 |
A-1893 | H | H | H | H | H | O | 环丙基 | H | 2-SMe,6-F | 0 |
A-1894 | H | H | H | H | H | O | 环丙基 | H | 2-SMe,5-Me | 0 |
A-1895 | H | H | H | H | H | O | 环丙基 | H | 2-SMe,6-Me | 0 |
A-1896 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)Me,5-F | 0 |
A-1897 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)Me,6-F | 0 |
A-1898 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)Me,5-Me | 0 |
A-1899 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)Me,6-Me | 0 |
A-1900 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-1901 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-1902 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-1903 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-1904 | H | H | H | H | H | O | 环丙基 | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-1905 | H | H | H | H | H | O | 环丙基 | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-1906 | H | H | H | H | H | O | 环丙基 | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-1907 | H | H | H | H | H | O | 环丙基 | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-1908 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-1909 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-1910 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-1911 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-1912 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-1913 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-1914 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-1915 | H | H | H | H | H | O | 环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-1916 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基硫基),5-F | 0 |
A-1917 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基硫基),6-F | 0 |
A-1918 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基硫基),5-Me | 0 |
A-1919 | H | H | H | H | H | O | 环丙基 | H | 2-(环丙基硫基),6-Me | 0 |
A-1920 | H | H | H | H | H | O | 环丙基 | H | 2-C(=O)Me,5-F | 0 |
A-1921 | H | H | H | H | H | O | 环丙基 | H | 2-C(=O)Me,6-F | 0 |
A-1922 | H | H | H | H | H | O | 环丙基 | H | 2-C(=O)Me,5-Me | 0 |
A-1923 | H | H | H | H | H | O | 环丙基 | H | 2-C(=O)Me,6-Me | 0 |
A-1924 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-1925 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-1926 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-1927 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-1928 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-1929 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-1930 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-1931 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-1932 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-1933 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
[表35]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-1934 | H | H | H | H | H | O | 环丙基 | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-1935 | H | H | H | H | H | O | 环丙基 | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-1936 | H | H | H | H | H | O | 环丙基 | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-1937 | H | H | H | H | H | O | 环丙基 | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-1938 | H | H | H | H | H | O | 环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-1939 | H | H | H | H | H | O | 环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-1940 | H | H | H | H | H | O | 环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-1941 | H | H | H | H | H | O | 环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-1942 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-1943 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-1944 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-1945 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-1946 | H | H | H | H | H | O | 环丙基 | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-1947 | H | H | H | H | H | O | 环丙基 | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-1948 | H | H | H | H | H | O | 环丙基 | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-1949 | H | H | H | H | H | O | 环丙基 | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-1950 | H | H | H | H | H | O | 环丙基 | H | 2-CN,4-F | 0 |
A-1951 | H | H | H | H | H | O | 环丙基 | H | 2-CN,5-F | 0 |
A-1952 | H | H | H | H | H | O | 环丙基 | H | 2-CN,6-F | 0 |
A-1953 | H | H | H | H | H | O | 环丙基 | H | 2-CN,6-Me | 0 |
A-1954 | H | H | H | H | H | O | 环丙基 | H | 2-CN,5-OMe | 0 |
A-1955 | H | H | H | H | H | O | 环丙基 | H | 2-CN,6-OMe | 0 |
A-1956 | H | H | H | H | H | O | 环丙基 | H | 3-CN,6-Me | 0 |
A-1957 | H | H | H | H | H | O | 环丙基 | H | 3-CN,6-OMe | 0 |
A-1958 | H | H | H | H | H | O | 环丙基 | H | 4-CN,2-Me | 0 |
A-1959 | H | H | H | H | H | O | 环丙基 | H | 4-CN,2-OMe | 0 |
A-1960 | H | H | H | H | H | O | 环丙基 | H | 2-NO<sub>2</sub>,4-F | 0 |
A-1961 | H | H | H | H | H | O | 环丙基 | H | 2-NO<sub>2</sub>,5-F | 0 |
A-1962 | H | H | H | H | H | O | 环丙基 | H | 2-NO<sub>2</sub>,6-F | 0 |
A-1963 | H | H | H | H | H | O | 环丙基 | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-1964 | H | H | H | H | H | O | 环丙基 | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-1965 | H | H | H | H | H | O | 环丙基 | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-1966 | H | H | H | H | H | O | 环丙基 | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-1967 | H | H | H | H | H | O | 环丙基 | H | 2-Me,6-Et | 0 |
A-1968 | H | H | H | H | H | O | 环丙基 | H | 2-环丙基,6-OMe | 0 |
A-1969 | H | H | H | H | H | O | 环丙基 | H | 2-Me,5-Et | 0 |
A-1970 | H | H | H | H | H | O | 环丙基 | H | 2,6-Et<sub>2</sub> | 0 |
A-1971 | H | H | H | H | H | O | 环丙基 | H | 2-Et,6-F | 0 |
A-1972 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-1973 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-1974 | H | H | H | H | H | O | 环丙基 | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-1975 | H | H | H | H | H | O | 环己基 | H | H | 0 |
A-1976 | H | H | H | H | H | O | 环己基 | H | 2-F | 0 |
A-1977 | H | H | H | H | H | O | 环己基 | H | 2-Cl | 0 |
A-1978 | H | H | H | H | H | O | 环己基 | H | 2-Br | 0 |
A-1979 | H | H | H | H | H | O | 环己基 | H | 2-OH | 0 |
A-1980 | H | H | H | H | H | O | 环己基 | H | 2-Me | 0 |
A-1981 | H | H | H | H | H | O | 环己基 | H | 2-Et | 0 |
A-1982 | H | H | H | H | H | O | 环己基 | H | 2-Pr | 0 |
A-1983 | H | H | H | H | H | O | 环己基 | H | 2-CF<sub>3</sub> | 0 |
A-1984 | H | H | H | H | H | O | 环己基 | H | 2-CHF<sub>2</sub> | 0 |
A-1985 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>F | 0 |
A-1986 | H | H | H | H | H | O | 环己基 | H | 2-CF<sub>2</sub>Cl | 0 |
A-1987 | H | H | H | H | H | O | 环己基 | H | 2-环丙基 | 0 |
A-1988 | H | H | H | H | H | O | 环己基 | H | 2-环丁基 | 0 |
A-1989 | H | H | H | H | H | O | 环己基 | H | 2-环戊基 | 0 |
A-1990 | H | H | H | H | H | O | 环己基 | H | 2-乙烯基 | 0 |
[表36]
[表37]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2048 | H | H | H | H | H | O | 环己基 | H | 2-Cl,6-Me | 0 |
A-2049 | H | H | H | H | H | O | 环己基 | H | 3-Cl,6-Me | 0 |
A-2050 | H | H | H | H | H | O | 环己基 | H | 4-Cl,2-Me | 0 |
A-2051 | H | H | H | H | H | O | 环己基 | H | 2-Cl,5-CF<sub>3</sub> | 0 |
A-2052 | H | H | H | H | H | O | 环己基 | H | 2-Cl,6-CF<sub>3</sub> | 0 |
A-2053 | H | H | H | H | H | O | 环己基 | H | 2-Cl,6-OMe | 0 |
A-2054 | H | H | H | H | H | O | 环己基 | H | 3-Cl,6-OMe | 0 |
A-2055 | H | H | H | H | H | O | 环己基 | H | 4-Cl,2-OMe | 0 |
A-2056 | H | H | H | H | H | O | 环己基 | H | 2,4-Me<sub>2</sub> | 0 |
A-2057 | H | H | H | H | H | O | 环己基 | H | 2,5-Me<sub>2</sub> | 0 |
A-2058 | H | H | H | H | H | O | 环己基 | H | 2,6-Me<sub>2</sub> | 0 |
A-2059 | H | H | H | H | H | O | 环己基 | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-2060 | H | H | H | H | H | O | 环己基 | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-2061 | H | H | H | H | H | O | 环己基 | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-2062 | H | H | H | H | H | O | 环己基 | H | 2-Me,4-OMe | 0 |
A-2063 | H | H | H | H | H | O | 环己基 | H | 2-Me,5-OMe | 0 |
A-2064 | H | H | H | H | H | O | 环己基 | H | 2-Me,6-OMe | 0 |
A-2065 | H | H | H | H | H | O | 环己基 | H | 3-Me,6-OMe | 0 |
A-2066 | H | H | H | H | H | O | 环己基 | H | 4-Me,2-OMe | 0 |
A-2067 | H | H | H | H | H | O | 环己基 | H | 2,5-OMe<sub>2</sub> | 0 |
A-2068 | H | H | H | H | H | O | 环己基 | H | 2,6-OMe<sub>2</sub> | 0 |
A-2069 | H | H | H | H | H | O | 环己基 | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-2070 | H | H | H | H | H | O | 环己基 | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-2071 | H | H | H | H | H | O | 环己基 | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-2072 | H | H | H | H | H | O | 环己基 | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-2073 | H | H | H | H | H | O | 环己基 | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-2074 | H | H | H | H | H | O | 环己基 | H | 2-环丙基,5-F | 0 |
A-2075 | H | H | H | H | H | O | 环己基 | H | 2-环丙基,6-F | 0 |
A-2076 | H | H | H | H | H | O | 环己基 | H | 2-环丙基,5-Me | 0 |
A-2077 | H | H | H | H | H | O | 环己基 | H | 2-环丙基,6-Me | 0 |
A-2078 | H | H | H | H | H | O | 环己基 | H | 2-乙烯基,6-F | 0 |
A-2079 | H | H | H | H | H | O | 环己基 | H | 2-乙烯基,6-Me | 0 |
A-2080 | H | H | H | H | H | O | 环己基 | H | 2-OEt,5-F | 0 |
A-2081 | H | H | H | H | H | O | 环己基 | H | 2-OEt,6-F | 0 |
A-2082 | H | H | H | H | H | O | 环己基 | H | 2-OEt,5-Cl | 0 |
A-2083 | H | H | H | H | H | O | 环己基 | H | 2-OEt,6-Cl | 0 |
A-2084 | H | H | H | H | H | O | 环己基 | H | 2-OEt,5-Me | 0 |
A-2085 | H | H | H | H | H | O | 环己基 | H | 2-OEt,6-Me | 0 |
A-2086 | H | H | H | H | H | O | 环己基 | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-2087 | H | H | H | H | H | O | 环己基 | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-2088 | H | H | H | H | H | O | 环己基 | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-2089 | H | H | H | H | H | O | 环己基 | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-2090 | H | H | H | H | H | O | 环己基 | H | 2-(环丙基氧基),5-F | 0 |
A-2091 | H | H | H | H | H | O | 环己基 | H | 2-(环丙基氧基),6-F | 0 |
A-2092 | H | H | H | H | H | O | 环己基 | H | 2-(环丙基氧基),5-Me | 0 |
A-2093 | H | H | H | H | H | O | 环己基 | H | 2-(环丙基氧基),6-Me | 0 |
A-2094 | H | H | H | H | H | O | 环己基 | H | 2-SMe,5-F | 0 |
A-2095 | H | H | H | H | H | O | 环己基 | H | 2-SMe,6-F | 0 |
A-2096 | H | H | H | H | H | O | 环己基 | H | 2-SMe,5-Me | 0 |
A-2097 | H | H | H | H | H | O | 环己基 | H | 2-SMe,6-Me | 0 |
A-2098 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)Me,5-F | 0 |
A-2099 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)Me,6-F | 0 |
A-2100 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)Me,5-Me | 0 |
A-2101 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)Me,6-Me | 0 |
A-2102 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-2103 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-2104 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
[表38]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2105 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-2106 | H | H | H | H | H | O | 环己基 | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-2107 | H | H | H | H | H | O | 环己基 | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-2108 | H | H | H | H | H | O | 环己基 | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-2109 | H | H | H | H | H | O | 环己基 | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-2110 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-2111 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-2112 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-2113 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-2114 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-2115 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-2116 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-2117 | H | H | H | H | H | O | 环己基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-2118 | H | H | H | H | H | O | 环己基 | H | 2-(环丙基硫基),5-F | 0 |
A-2119 | H | H | H | H | H | O | 环己基 | H | 2-(环丙基硫基),6-F | 0 |
A-2120 | H | H | H | H | H | O | 环己基 | H | 2-(环丙基硫基),5-Me | 0 |
A-2121 | H | H | H | H | H | O | 环己基 | H | 2-(环丙基硫基),6-Me | 0 |
A-2122 | H | H | H | H | H | O | 环己基 | H | 2-C(=O)Me,5-F | 0 |
A-2123 | H | H | H | H | H | O | 环己基 | H | 2-C(=O)Me,6-F | 0 |
A-2124 | H | H | H | H | H | O | 环己基 | H | 2-C(=O)Me,5-Me | 0 |
A-2125 | H | H | H | H | H | O | 环己基 | H | 2-C(=O)Me,6-Me | 0 |
A-2126 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-2127 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-2128 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-2129 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-2130 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-2131 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-2132 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-2133 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-2134 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-2135 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-2136 | H | H | H | H | H | O | 环己基 | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-2137 | H | H | H | H | H | O | 环己基 | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-2138 | H | H | H | H | H | O | 环己基 | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-2139 | H | H | H | H | H | O | 环己基 | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-2140 | H | H | H | H | H | O | 环己基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-2141 | H | H | H | H | H | O | 环己基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-2142 | H | H | H | H | H | O | 环己基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-2143 | H | H | H | H | H | O | 环己基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-2144 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-2145 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-2146 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-2147 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-2148 | H | H | H | H | H | O | 环己基 | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-2149 | H | H | H | H | H | O | 环己基 | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-2150 | H | H | H | H | H | O | 环己基 | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-2151 | H | H | H | H | H | O | 环己基 | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-2152 | H | H | H | H | H | O | 环己基 | H | 2-CN,4-F | 0 |
A-2153 | H | H | H | H | H | O | 环己基 | H | 2-CN,5-F | 0 |
A-2154 | H | H | H | H | H | O | 环己基 | H | 2-CN,6-F | 0 |
A-2155 | H | H | H | H | H | O | 环己基 | H | 2-CN,6-Me | 0 |
A-2156 | H | H | H | H | H | O | 环己基 | H | 2-CN,5-OMe | 0 |
A-2157 | H | H | H | H | H | O | 环己基 | H | 2-CN,6-OMe | 0 |
A-2158 | H | H | H | H | H | O | 环己基 | H | 3-CN,6-Me | 0 |
A-2159 | H | H | H | H | H | O | 环己基 | H | 3-CN,6-OMe | 0 |
A-2160 | H | H | H | H | H | O | 环己基 | H | 4-CN,2-Me | 0 |
A-2161 | H | H | H | H | H | O | 环己基 | H | 4-CN,2-OMe | 0 |
[表39]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2162 | H | H | H | H | H | O | 环己基 | H | 2-NO<sub>2</sub>,4-F | 0 |
A-2163 | H | H | H | H | H | O | 环己基 | H | 2-NO<sub>2</sub>,5-F | 0 |
A-2164 | H | H | H | H | H | O | 环己基 | H | 2-NO<sub>2</sub>,6-F | 0 |
A-2165 | H | H | H | H | H | O | 环己基 | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-2166 | H | H | H | H | H | O | 环己基 | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-2167 | H | H | H | H | H | O | 环己基 | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-2168 | H | H | H | H | H | O | 环己基 | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-2169 | H | H | H | H | H | O | 环己基 | H | 2-Me,6-Et | 0 |
A-2170 | H | H | H | H | H | O | 环己基 | H | 2-环丙基,6-OMe | 0 |
A-2171 | H | H | H | H | H | O | 环己基 | H | 2-Me,5-Et | 0 |
A-2172 | H | H | H | H | H | O | 环己基 | H | 2,6-Et<sub>2</sub> | 0 |
A-2173 | H | H | H | H | H | O | 环己基 | H | 2-Et,6-F | 0 |
A-2174 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-2175 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-2176 | H | H | H | H | H | O | 环己基 | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-2177 | H | H | H | H | H | O | 烯丙基 | H | H | 0 |
A-2178 | H | H | H | H | H | O | 烯丙基 | H | 2-F | 0 |
A-2179 | H | H | H | H | H | O | 烯丙基 | H | 2-Cl | 0 |
A-2180 | H | H | H | H | H | O | 烯丙基 | H | 2-Br | 0 |
A-2181 | H | H | H | H | H | O | 烯丙基 | H | 2-OH | 0 |
A-2182 | H | H | H | H | H | O | 烯丙基 | H | 2-Me | 0 |
A-2183 | H | H | H | H | H | O | 烯丙基 | H | 2-Et | 0 |
A-2184 | H | H | H | H | H | O | 烯丙基 | H | 2-Pr | 0 |
A-2185 | H | H | H | H | H | O | 烯丙基 | H | 2-CF<sub>3</sub> | 0 |
A-2186 | H | H | H | H | H | O | 烯丙基 | H | 2-CHF<sub>2</sub> | 0 |
A-2187 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>F | 0 |
A-2188 | H | H | H | H | H | O | 烯丙基 | H | 2-CF<sub>2</sub>Cl | 0 |
A-2189 | H | H | H | H | H | O | 烯丙基 | H | 2-环丙基 | 0 |
A-2190 | H | H | H | H | H | O | 烯丙基 | H | 2-环丁基 | 0 |
A-2191 | H | H | H | H | H | O | 烯丙基 | H | 2-环戊基 | 0 |
A-2192 | H | H | H | H | H | O | 烯丙基 | H | 2-乙烯基 | 0 |
A-2193 | H | H | H | H | H | O | 烯丙基 | H | 2-烯丙基 | 0 |
A-2194 | H | H | H | H | H | O | 烯丙基 | H | 2-(丙-1-烯-1-基) | 0 |
A-2195 | H | H | H | H | H | O | 烯丙基 | H | 2-(三氟乙烯基) | 0 |
A-2196 | H | H | H | H | H | O | 烯丙基 | H | 2-OMe | 0 |
A-2197 | H | H | H | H | H | O | 烯丙基 | H | 2-OEt | 0 |
A-2198 | H | H | H | H | H | O | 烯丙基 | H | 2-OPr | 0 |
A-2199 | H | H | H | H | H | O | 烯丙基 | H | 2-O(i-Pr) | 0 |
A-2200 | H | H | H | H | H | O | 烯丙基 | H | 2-OCF<sub>3</sub> | 0 |
A-2201 | H | H | H | H | H | O | 烯丙基 | H | 2-OCHF<sub>2</sub> | 0 |
A-2202 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基氧基) | 0 |
A-2203 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丁基氧基) | 0 |
A-2204 | H | H | H | H | H | O | 烯丙基 | H | 2-(环戊基氧基) | 0 |
A-2205 | H | H | H | H | H | O | 烯丙基 | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-2206 | H | H | H | H | H | O | 烯丙基 | H | 2-(环氧乙烷-2-基) | 0 |
A-2207 | H | H | H | H | H | O | 烯丙基 | H | 2-SMe | 0 |
A-2208 | H | H | H | H | H | O | 烯丙基 | H | 3-SMe | 0 |
A-2209 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)Me | 0 |
A-2210 | H | H | H | H | H | O | 烯丙基 | H | 3-S(=O)Me | 0 |
A-2211 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-2212 | H | H | H | H | H | O | 烯丙基 | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-2213 | H | H | H | H | H | O | 烯丙基 | H | 2-SCF<sub>3</sub> | 0 |
A-2214 | H | H | H | H | H | O | 烯丙基 | H | 3-SCF<sub>3</sub> | 0 |
A-2215 | H | H | H | H | H | O | 烯丙基 | H | 3-S(=O)CF<sub>3</sub> | 0 |
A-2216 | H | H | H | H | H | O | 烯丙基 | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-2217 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基硫基) | 0 |
A-2218 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基亚磺酰基) | 0 |
[表40]
[表41]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2276 | H | H | H | H | H | O | 烯丙基 | H | 2-环丙基,5-F | 0 |
A-2277 | H | H | H | H | H | O | 烯丙基 | H | 2-环丙基,6-F | 0 |
A-2278 | H | H | H | H | H | O | 烯丙基 | H | 2-环丙基,5-Me | 0 |
A-2279 | H | H | H | H | H | O | 烯丙基 | H | 2-环丙基,6-Me | 0 |
A-2280 | H | H | H | H | H | O | 烯丙基 | H | 2-乙烯基,6-F | 0 |
A-2281 | H | H | H | H | H | O | 烯丙基 | H | 2-乙烯基,6-Me | 0 |
A-2282 | H | H | H | H | H | O | 烯丙基 | H | 2-OEt,5-F | 0 |
A-2283 | H | H | H | H | H | O | 烯丙基 | H | 2-OEt,6-F | 0 |
A-2284 | H | H | H | H | H | O | 烯丙基 | H | 2-OEt,5-Cl | 0 |
A-2285 | H | H | H | H | H | O | 烯丙基 | H | 2-OEt,6-Cl | 0 |
A-2286 | H | H | H | H | H | O | 烯丙基 | H | 2-OEt,5-Me | 0 |
A-2287 | H | H | H | H | H | O | 烯丙基 | H | 2-OEt,6-Me | 0 |
A-2288 | H | H | H | H | H | O | 烯丙基 | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-2289 | H | H | H | H | H | O | 烯丙基 | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-2290 | H | H | H | H | H | O | 烯丙基 | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-2291 | H | H | H | H | H | O | 烯丙基 | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-2292 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基氧基),5-F | 0 |
A-2293 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基氧基),6-F | 0 |
A-2294 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基氧基),5-Me | 0 |
A-2295 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基氧基),6-Me | 0 |
A-2296 | H | H | H | H | H | O | 烯丙基 | H | 2-SMe,5-F | 0 |
A-2297 | H | H | H | H | H | O | 烯丙基 | H | 2-SMe,6-F | 0 |
A-2298 | H | H | H | H | H | O | 烯丙基 | H | 2-SMe,5-Me | 0 |
A-2299 | H | H | H | H | H | O | 烯丙基 | H | 2-SMe,6-Me | 0 |
A-2300 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)Me,5-F | 0 |
A-2301 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)Me,6-F | 0 |
A-2302 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)Me,5-Me | 0 |
A-2303 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)Me,6-Me | 0 |
A-2304 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-2305 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-2306 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-2307 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-2308 | H | H | H | H | H | O | 烯丙基 | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-2309 | H | H | H | H | H | O | 烯丙基 | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-2310 | H | H | H | H | H | O | 烯丙基 | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-2311 | H | H | H | H | H | O | 烯丙基 | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-2312 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-2313 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-2314 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-2315 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-2316 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-2317 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-2318 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-2319 | H | H | H | H | H | O | 烯丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-2320 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基硫基),5-F | 0 |
A-2321 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基硫基),6-F | 0 |
A-2322 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基硫基),5-Me | 0 |
A-2323 | H | H | H | H | H | O | 烯丙基 | H | 2-(环丙基硫基),6-Me | 0 |
A-2324 | H | H | H | H | H | O | 烯丙基 | H | 2-C(=O)Me,5-F | 0 |
A-2325 | H | H | H | H | H | O | 烯丙基 | H | 2-C(=O)Me,6-F | 0 |
A-2326 | H | H | H | H | H | O | 烯丙基 | H | 2-C(=O)Me,5-Me | 0 |
A-2327 | H | H | H | H | H | O | 烯丙基 | H | 2-C(=O)Me,6-Me | 0 |
A-2328 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-2329 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-2330 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-2331 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-2332 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
[表42]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2333 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-2334 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-2335 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-2336 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-2337 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-2338 | H | H | H | H | H | O | 烯丙基 | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-2339 | H | H | H | H | H | O | 烯丙基 | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-2340 | H | H | H | H | H | O | 烯丙基 | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-2341 | H | H | H | H | H | O | 烯丙基 | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-2342 | H | H | H | H | H | O | 烯丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-2343 | H | H | H | H | H | O | 烯丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-2344 | H | H | H | H | H | O | 烯丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-2345 | H | H | H | H | H | O | 烯丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-2346 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-2347 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-2348 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-2349 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-2350 | H | H | H | H | H | O | 烯丙基 | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-2351 | H | H | H | H | H | O | 烯丙基 | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-2352 | H | H | H | H | H | O | 烯丙基 | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-2353 | H | H | H | H | H | O | 烯丙基 | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-2354 | H | H | H | H | H | O | 烯丙基 | H | 2-CN,4-F | 0 |
A-2355 | H | H | H | H | H | O | 烯丙基 | H | 2-CN,5-F | 0 |
A-2356 | H | H | H | H | H | O | 烯丙基 | H | 2-CN,6-F | 0 |
A-2357 | H | H | H | H | H | O | 烯丙基 | H | 2-CN,6-Me | 0 |
A-2358 | H | H | H | H | H | O | 烯丙基 | H | 2-CN,5-OMe | 0 |
A-2359 | H | H | H | H | H | O | 烯丙基 | H | 2-CN,6-OMe | 0 |
A-2360 | H | H | H | H | H | O | 烯丙基 | H | 3-CN,6-Me | 0 |
A-2361 | H | H | H | H | H | O | 烯丙基 | H | 3-CN,6-OMe | 0 |
A-2362 | H | H | H | H | H | O | 烯丙基 | H | 4-CN,2-Me | 0 |
A-2363 | H | H | H | H | H | O | 烯丙基 | H | 4-CN,2-OMe | 0 |
A-2364 | H | H | H | H | H | O | 烯丙基 | H | 2-NO<sub>2</sub>,4-F | 0 |
A-2365 | H | H | H | H | H | O | 烯丙基 | H | 2-NO<sub>2</sub>,5-F | 0 |
A-2366 | H | H | H | H | H | O | 烯丙基 | H | 2-NO<sub>2</sub>,6-F | 0 |
A-2367 | H | H | H | H | H | O | 烯丙基 | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-2368 | H | H | H | H | H | O | 烯丙基 | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-2369 | H | H | H | H | H | O | 烯丙基 | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-2370 | H | H | H | H | H | O | 烯丙基 | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-2371 | H | H | H | H | H | O | 烯丙基 | H | 2-Me,6-Et | 0 |
A-2372 | H | H | H | H | H | O | 烯丙基 | H | 2-环丙基,6-OMe | 0 |
A-2373 | H | H | H | H | H | O | 烯丙基 | H | 2-Me,5-Et | 0 |
A-2374 | H | H | H | H | H | O | 烯丙基 | H | 2,6-Et<sub>2</sub> | 0 |
A-2375 | H | H | H | H | H | O | 烯丙基 | H | 2-Et,6-F | 0 |
A-2376 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-2377 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-2378 | H | H | H | H | H | O | 烯丙基 | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-2379 | H | H | H | H | H | O | 1-环己基乙基 | H | H | 0 |
A-2380 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-F | 0 |
A-2381 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Cl | 0 |
A-2382 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Br | 0 |
A-2383 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OH | 0 |
A-2384 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Me | 0 |
A-2385 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Et | 0 |
A-2386 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Pr | 0 |
A-2387 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CF<sub>3</sub> | 0 |
A-2388 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CHF<sub>2</sub> | 0 |
A-2389 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>F | 0 |
[表43]
[表44]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2447 | H | H | H | H | H | O | 1-环己基乙基 | H | 3-F,6-Me | 0 |
A-2448 | H | H | H | H | H | O | 1-环己基乙基 | H | 4-F,2-Me | 0 |
A-2449 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-F,6-OMe | 0 |
A-2450 | H | H | H | H | H | O | 1-环己基乙基 | H | 3-F,6-OMe | 0 |
A-2451 | H | H | H | H | H | O | 1-环己基乙基 | H | 2,6-Cl<sub>2</sub> | 0 |
A-2452 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Cl,6-Me | 0 |
A-2453 | H | H | H | H | H | O | 1-环己基乙基 | H | 3-Cl,6-Me | 0 |
A-2454 | H | H | H | H | H | O | 1-环己基乙基 | H | 4-Cl,2-Me | 0 |
A-2455 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Cl,5-CF<sub>3</sub> | 0 |
A-2456 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Cl,6-CF<sub>3</sub> | 0 |
A-2457 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Cl,6-OMe | 0 |
A-2458 | H | H | H | H | H | O | 1-环己基乙基 | H | 3-Cl,6-OMe | 0 |
A-2459 | H | H | H | H | H | O | 1-环己基乙基 | H | 4-Cl,2-OMe | 0 |
A-2460 | H | H | H | H | H | O | 1-环己基乙基 | H | 2,4-Me<sub>2</sub> | 0 |
A-2461 | H | H | H | H | H | O | 1-环己基乙基 | H | 2,5-Me<sub>2</sub> | 0 |
A-2462 | H | H | H | H | H | O | 1-环己基乙基 | H | 2,6-Me<sub>2</sub> | 0 |
A-2463 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-2464 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-2465 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-2466 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Me,4-OMe | 0 |
A-2467 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Me,5-OMe | 0 |
A-2468 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Me,6-OMe | 0 |
A-2469 | H | H | H | H | H | O | 1-环己基乙基 | H | 3-Me,6-OMe | 0 |
A-2470 | H | H | H | H | H | O | 1-环己基乙基 | H | 4-Me,2-OMe | 0 |
A-2471 | H | H | H | H | H | O | 1-环己基乙基 | H | 2,5-OMe<sub>2</sub> | 0 |
A-2472 | H | H | H | H | H | O | 1-环己基乙基 | H | 2,6-OMe<sub>2</sub> | 0 |
A-2473 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-2474 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-2475 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-2476 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-2477 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-2478 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-环丙基,5-F | 0 |
A-2479 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-环丙基,6-F | 0 |
A-2480 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-环丙基,5-Me | 0 |
A-2481 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-环丙基,6-Me | 0 |
A-2482 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-乙烯基,6-F | 0 |
A-2483 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-乙烯基,6-Me | 0 |
A-2484 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OEt,5-F | 0 |
A-2485 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OEt,6-F | 0 |
A-2486 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OEt,5-Cl | 0 |
A-2487 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OEt,6-Cl | 0 |
A-2488 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OEt,5-Me | 0 |
A-2489 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OEt,6-Me | 0 |
A-2490 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-2491 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-2492 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-2493 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-2494 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-(环丙基氧基),5-F | 0 |
A-2495 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-(环丙基氧基),6-F | 0 |
A-2496 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-(环丙基氧基),5-Me | 0 |
A-2497 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-(环丙基氧基),6-Me | 0 |
A-2498 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-SMe,5-F | 0 |
A-2499 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-SMe,6-F | 0 |
A-2500 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-SMe,5-Me | 0 |
A-2501 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-SMe,6-Me | 0 |
A-2502 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)Me,5-F | 0 |
A-2503 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)Me,6-F | 0 |
[表45]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2504 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)Me,5-Me | 0 |
A-2505 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)Me,6-Me | 0 |
A-2506 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-2507 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-2508 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-2509 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-2510 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-2511 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-2512 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-2513 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-2514 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-2515 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-2516 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-2517 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-2518 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-2519 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-2520 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-2521 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-2522 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-(环丙基硫基),5-F | 0 |
A-2523 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-(环丙基硫基),6-F | 0 |
A-2524 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-(环丙基硫基),5-Me | 0 |
A-2525 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-(环丙基硫基),6-Me | 0 |
A-2526 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-C(=O)Me,5-F | 0 |
A-2527 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-C(=O)Me,6-F | 0 |
A-2528 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-C(=O)Me,5-Me | 0 |
A-2529 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-C(=O)Me,6-Me | 0 |
A-2530 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-2531 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-2532 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-2533 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-2534 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-2535 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-2536 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-2537 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-2538 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-2539 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-2540 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-2541 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-2542 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-2543 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-2544 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-2545 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-2546 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-2547 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-2548 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-2549 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-2550 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-2551 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-2552 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-2553 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-2554 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-2555 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-2556 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CN,4-F | 0 |
A-2557 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CN,5-F | 0 |
A-2558 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CN,6-F | 0 |
A-2559 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CN,6-Me | 0 |
A-2560 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CN,5-OMe | 0 |
[表46]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2561 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CN,6-OMe | 0 |
A-2562 | H | H | H | H | H | O | 1-环己基乙基 | H | 3-CN,6-Me | 0 |
A-2563 | H | H | H | H | H | O | 1-环己基乙基 | H | 3-CN,6-OMe | 0 |
A-2564 | H | H | H | H | H | O | 1-环己基乙基 | H | 4-CN,2-Me | 0 |
A-2565 | H | H | H | H | H | O | 1-环己基乙基 | H | 4-CN,2-OMe | 0 |
A-2566 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-NO<sub>2</sub>,4-F | 0 |
A-2567 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-NO<sub>2</sub>,5-F | 0 |
A-2568 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-NO<sub>2</sub>,6-F | 0 |
A-2569 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-2570 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-2571 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-2572 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-2573 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Me,6-Et | 0 |
A-2574 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-环丙基,6-OMe | 0 |
A-2575 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Me,5-Et | 0 |
A-2576 | H | H | H | H | H | O | 1-环己基乙基 | H | 2,6-Et<sub>2</sub> | 0 |
A-2577 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-Et,6-F | 0 |
A-2578 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-2579 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-2580 | H | H | H | H | H | O | 1-环己基乙基 | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-2581 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | H | 0 |
A-2582 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-F | 0 |
A-2583 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-Cl | 0 |
A-2584 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-Br | 0 |
A-2585 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OH | 0 |
A-2586 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-Me | 0 |
A-2587 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-Et | 0 |
A-2588 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-Pr | 0 |
A-2589 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CF<sub>3</sub> | 0 |
A-2590 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CHF<sub>2</sub> | 0 |
A-2591 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>F | 0 |
A-2592 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CF<sub>2</sub>Cl | 0 |
A-2593 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-环丙基 | 0 |
A-2594 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-环丁基 | 0 |
A-2595 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-环戊基 | 0 |
A-2596 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-乙烯基 | 0 |
A-2597 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-烯丙基 | 0 |
A-2598 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(丙-1-烯-1-基) | 0 |
A-2599 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(三氟乙烯基) | 0 |
A-2600 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OMe | 0 |
A-2601 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OEt | 0 |
A-2602 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OPr | 0 |
A-2603 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-O(i-Pr) | 0 |
A-2604 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OCF<sub>3</sub> | 0 |
A-2605 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OCHF<sub>2</sub> | 0 |
A-2606 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环丙基氧基) | 0 |
A-2607 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环丁基氧基) | 0 |
A-2608 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环戊基氧基) | 0 |
A-2609 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-2610 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环氧乙烷-2-基) | 0 |
A-2611 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-SMe | 0 |
A-2612 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 3-SMe | 0 |
A-2613 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)Me | 0 |
A-2614 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 3-S(=O)Me | 0 |
A-2615 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-2616 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-2617 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-SCF<sub>3</sub> | 0 |
[表47]
[表48]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2675 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-2676 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-2677 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-2678 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-2679 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-2680 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-环丙基,5-F | 0 |
A-2681 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-环丙基,6-F | 0 |
A-2682 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-环丙基,5-Me | 0 |
A-2683 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-环丙基,6-Me | 0 |
A-2684 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-乙烯基,6-F | 0 |
A-2685 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-乙烯基,6-Me | 0 |
A-2686 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OEt,5-F | 0 |
A-2687 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OEt,6-F | 0 |
A-2688 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OEt,5-Cl | 0 |
A-2689 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OEt,6-Cl | 0 |
A-2690 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OEt,5-Me | 0 |
A-2691 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OEt,6-Me | 0 |
A-2692 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-2693 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-2694 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-2695 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-2696 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环丙基氧基),5-F | 0 |
A-2697 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环丙基氧基),6-F | 0 |
A-2698 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环丙基氧基),5-Me | 0 |
A-2699 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环丙基氧基),6-Me | 0 |
A-2700 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-SMe,5-F | 0 |
A-2701 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-SMe,6-F | 0 |
A-2702 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-SMe,5-Me | 0 |
A-2703 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-SMe,6-Me | 0 |
A-2704 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)Me,5-F | 0 |
A-2705 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)Me,6-F | 0 |
A-2706 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)Me,5-Me | 0 |
A-2707 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)Me,6-Me | 0 |
A-2708 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-2709 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-2710 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-2711 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-2712 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-2713 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-2714 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-2715 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-2716 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-2717 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-2718 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-2719 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-2720 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-2721 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-2722 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-2723 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-2724 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环丙基硫基),5-F | 0 |
A-2725 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环丙基硫基),6-F | 0 |
A-2726 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环丙基硫基),5-Me | 0 |
A-2727 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-(环丙基硫基),6-Me | 0 |
A-2728 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-C(=O)Me,5-F | 0 |
A-2729 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-C(=O)Me,6-F | 0 |
A-2730 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-C(=O)Me,5-Me | 0 |
A-2731 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-C(=O)Me,6-Me | 0 |
[表49]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2732 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-2733 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-2734 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-2735 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-2736 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-2737 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-2738 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-2739 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-2740 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-2741 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-2742 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-2743 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-2744 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-2745 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-2746 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-2747 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-2748 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-2749 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-2750 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-2751 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-2752 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-2753 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-2754 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-2755 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-2756 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-2757 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-2758 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CN,4-F | 0 |
A-2759 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CN,5-F | 0 |
A-2760 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CN,6-F | 0 |
A-2761 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CN,6-Me | 0 |
A-2762 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CN,5-OMe | 0 |
A-2763 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CN,6-OMe | 0 |
A-2764 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 3-CN,6-Me | 0 |
A-2765 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 3-CN,6-OMe | 0 |
A-2766 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 4-CN,2-Me | 0 |
A-2767 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 4-CN,2-OMe | 0 |
A-2768 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-NO<sub>2</sub>,4-F | 0 |
A-2769 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-NO<sub>2</sub>,5-F | 0 |
A-2770 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-NO<sub>2</sub>,6-F | 0 |
A-2771 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-2772 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-2773 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-2774 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-2775 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-Me,6-Et | 0 |
A-2776 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-环丙基,6-OMe | 0 |
A-2777 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-Me,5-Et | 0 |
A-2778 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2,6-Et<sub>2</sub> | 0 |
A-2779 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-Et,6-F | 0 |
A-2780 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-2781 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-2782 | H | H | H | H | H | O | CH<sub>2</sub>C≡CH | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-2783 | H | H | H | H | H | O | OH | H | H | 0 |
A-2784 | H | H | H | H | H | O | OH | H | 2-F | 0 |
A-2785 | H | H | H | H | H | O | OH | H | 2-Cl | 0 |
A-2786 | H | H | H | H | H | O | OH | H | 2-Br | 0 |
A-2787 | H | H | H | H | H | O | OH | H | 2-OH | 0 |
A-2788 | H | H | H | H | H | O | OH | H | 2-Me | 0 |
[表50]
[表51]
[表52]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2903 | H | H | H | H | H | O | OH | H | 2-SMe,6-F | 0 |
A-2904 | H | H | H | H | H | O | OH | H | 2-SMe,5-Me | 0 |
A-2905 | H | H | H | H | H | O | OH | H | 2-SMe,6-Me | 0 |
A-2906 | H | H | H | H | H | O | OH | H | 2-S(=O)Me,5-F | 0 |
A-2907 | H | H | H | H | H | O | OH | H | 2-S(=O)Me,6-F | 0 |
A-2908 | H | H | H | H | H | O | OH | H | 2-S(=O)Me,5-Me | 0 |
A-2909 | H | H | H | H | H | O | OH | H | 2-S(=O)Me,6-Me | 0 |
A-2910 | H | H | H | H | H | O | OH | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-2911 | H | H | H | H | H | O | OH | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-2912 | H | H | H | H | H | O | OH | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-2913 | H | H | H | H | H | O | OH | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-2914 | H | H | H | H | H | O | OH | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-2915 | H | H | H | H | H | O | OH | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-2916 | H | H | H | H | H | O | OH | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-2917 | H | H | H | H | H | O | OH | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-2918 | H | H | H | H | H | O | OH | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-2919 | H | H | H | H | H | O | OH | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-2920 | H | H | H | H | H | O | OH | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-2921 | H | H | H | H | H | O | OH | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-2922 | H | H | H | H | H | O | OH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-2923 | H | H | H | H | H | O | OH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-2924 | H | H | H | H | H | O | OH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-2925 | H | H | H | H | H | O | OH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-2926 | H | H | H | H | H | O | OH | H | 2-(环丙基硫基),5-F | 0 |
A-2927 | H | H | H | H | H | O | OH | H | 2-(环丙基硫基),6-F | 0 |
A-2928 | H | H | H | H | H | O | OH | H | 2-(环丙基硫基),5-Me | 0 |
A-2929 | H | H | H | H | H | O | OH | H | 2-(环丙基硫基),6-Me | 0 |
A-2930 | H | H | H | H | H | O | OH | H | 2-C(=O)Me,5-F | 0 |
A-2931 | H | H | H | H | H | O | OH | H | 2-C(=O)Me,6-F | 0 |
A-2932 | H | H | H | H | H | O | OH | H | 2-C(=O)Me,5-Me | 0 |
A-2933 | H | H | H | H | H | O | OH | H | 2-C(=O)Me,6-Me | 0 |
A-2934 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-2935 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-2936 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-2937 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-2938 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-2939 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-2940 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-2941 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-2942 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-2943 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-2944 | H | H | H | H | H | O | OH | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-2945 | H | H | H | H | H | O | OH | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-2946 | H | H | H | H | H | O | OH | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-2947 | H | H | H | H | H | O | OH | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-2948 | H | H | H | H | H | O | OH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-2949 | H | H | H | H | H | O | OH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-2950 | H | H | H | H | H | O | OH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-2951 | H | H | H | H | H | O | OH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-2952 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-2953 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-2954 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-2955 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-2956 | H | H | H | H | H | O | OH | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-2957 | H | H | H | H | H | O | OH | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-2958 | H | H | H | H | H | O | OH | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-2959 | H | H | H | H | H | O | OH | H | 2-NMe<sub>2</sub>,6-Me | 0 |
[表53]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-2960 | H | H | H | H | H | O | OH | H | 2-CN,4-F | 0 |
A-2961 | H | H | H | H | H | O | OH | H | 2-CN,5-F | 0 |
A-2962 | H | H | H | H | H | O | OH | H | 2-CN,6-F | 0 |
A-2963 | H | H | H | H | H | O | OH | H | 2-CN,6-Me | 0 |
A-2964 | H | H | H | H | H | O | OH | H | 2-CN,5-OMe | 0 |
A-2965 | H | H | H | H | H | O | OH | H | 2-CN,6-OMe | 0 |
A-2966 | H | H | H | H | H | O | OH | H | 3-CN,6-Me | 0 |
A-2967 | H | H | H | H | H | O | OH | H | 3-CN,6-OMe | 0 |
A-2968 | H | H | H | H | H | O | OH | H | 4-CN,2-Me | 0 |
A-2969 | H | H | H | H | H | O | OH | H | 4-CN,2-OMe | 0 |
A-2970 | H | H | H | H | H | O | OH | H | 2-NO<sub>2</sub>,4-F | 0 |
A-2971 | H | H | H | H | H | O | OH | H | 2-NO<sub>2</sub>,5-F | 0 |
A-2972 | H | H | H | H | H | O | OH | H | 2-NO<sub>2</sub>,6-F | 0 |
A-2973 | H | H | H | H | H | O | OH | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-2974 | H | H | H | H | H | O | OH | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-2975 | H | H | H | H | H | O | OH | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-2976 | H | H | H | H | H | O | OH | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-2977 | H | H | H | H | H | O | OH | H | 2-Me,6-Et | 0 |
A-2978 | H | H | H | H | H | O | OH | H | 2-环丙基,6-OMe | 0 |
A-2979 | H | H | H | H | H | O | OH | H | 2-Me,5-Et | 0 |
A-2980 | H | H | H | H | H | O | OH | H | 2,6-Et<sub>2</sub> | 0 |
A-2981 | H | H | H | H | H | O | OH | H | 2-Et,6-F | 0 |
A-2982 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-2983 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-2984 | H | H | H | H | H | O | OH | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-2985 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | H | 0 |
A-2986 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-F | 0 |
A-2987 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Cl | 0 |
A-2988 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Br | 0 |
A-2989 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OH | 0 |
A-2990 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Me | 0 |
A-2991 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Et | 0 |
A-2992 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Pr | 0 |
A-2993 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CF<sub>3</sub> | 0 |
A-2994 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-2995 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-2996 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-2997 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基 | 0 |
A-2998 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-环丁基 | 0 |
A-2999 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-环戊基 | 0 |
A-3000 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-乙烯基 | 0 |
A-3001 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-烯丙基 | 0 |
A-3002 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-3003 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(三氟乙烯基) | 0 |
A-3004 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OMe | 0 |
A-3005 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt | 0 |
A-3006 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OPr | 0 |
A-3007 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-O(i-Pr) | 0 |
A-3008 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OCF<sub>3</sub> | 0 |
A-3009 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub> | 0 |
A-3010 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基) | 0 |
A-3011 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丁基氧基) | 0 |
A-3012 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环戊基氧基) | 0 |
A-3013 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-3014 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环氧乙烷-2-基) | 0 |
A-3015 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe | 0 |
A-3016 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 3-SMe | 0 |
[表54]
[表55]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3074 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,6-OMe | 0 |
A-3075 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 3-Me,6-OMe | 0 |
A-3076 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 4-Me,2-OMe | 0 |
A-3077 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2,5-OMe<sub>2</sub> | 0 |
A-3078 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2,6-OMe<sub>2</sub> | 0 |
A-3079 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-3080 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-3081 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-3082 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-3083 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-3084 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,5-F | 0 |
A-3085 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-F | 0 |
A-3086 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,5-Me | 0 |
A-3087 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-Me | 0 |
A-3088 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-乙烯基,6-F | 0 |
A-3089 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-乙烯基,6-Me | 0 |
A-3090 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,5-F | 0 |
A-3091 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,6-F | 0 |
A-3092 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,5-Cl | 0 |
A-3093 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,6-Cl | 0 |
A-3094 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,5-Me | 0 |
A-3095 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,6-Me | 0 |
A-3096 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-3097 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-3098 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-3099 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-3100 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-3101 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-3102 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-3103 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-3104 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-3105 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-3106 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-3107 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-3108 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-3109 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-3110 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-3111 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-3112 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-3113 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-3114 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-3115 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-3116 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-3117 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-3118 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-3119 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-3120 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-3121 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-3122 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-3123 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-3124 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-3125 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-3126 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-3127 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-3128 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-3129 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-3130 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
[表56]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3131 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-3132 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-3133 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-3134 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-3135 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-3136 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-3137 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-3138 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-3139 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-3140 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-3141 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-3142 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-3143 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-3144 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-3145 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-3146 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-3147 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-3148 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-3149 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-3150 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-3151 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-3152 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-3153 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-3154 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-3155 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-3156 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-3157 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-3158 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-3159 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-3160 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-3161 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-3162 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-3163 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-3164 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-3165 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-3166 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-3167 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-3168 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-3169 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-3170 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-3171 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-3172 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-3173 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-3174 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-3175 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-3176 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-3177 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-3178 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-3179 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-3180 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-3181 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-3182 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-3183 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-3184 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-3185 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-3186 | H | H | H | H | H | O | OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-3187 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | H | 0 |
[表57]
[表58]
[表59]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3302 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-3303 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-3304 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-3305 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-3306 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-3307 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-3308 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-3309 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-3310 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-3311 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-3312 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-3313 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-3314 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-3315 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-3316 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-3317 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-3318 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-3319 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-3320 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-3321 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-3322 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-3323 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-3324 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-3325 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-3326 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-3327 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-3328 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-3329 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-3330 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-3331 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-3332 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-3333 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-3334 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-3335 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-3336 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-3337 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-3338 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-3339 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-3340 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-3341 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-3342 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-3343 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-3344 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-3345 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-3346 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-3347 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-3348 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-3349 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-3350 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-3351 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-3352 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-3353 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-3354 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-3355 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-3356 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-3357 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-3358 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
[表60]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3359 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-3360 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-3361 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-3362 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-3363 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-3364 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CN,4-F | 0 |
A-3365 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CN,5-F | 0 |
A-3366 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CN,6-F | 0 |
A-3367 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-3368 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-3369 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-3370 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-3371 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-3372 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-3373 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-3374 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-3375 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-3376 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-3377 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-3378 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-3379 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-3380 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-3381 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-3382 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-3383 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-3384 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-3385 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-Et,6-F | 0 |
A-3386 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-3387 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-3388 | H | H | H | H | H | O | CH<sub>2</sub>CF<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-3389 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | H | 0 |
A-3390 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-F | 0 |
A-3391 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Cl | 0 |
A-3392 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Br | 0 |
A-3393 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OH | 0 |
A-3394 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Me | 0 |
A-3395 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Et | 0 |
A-3396 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Pr | 0 |
A-3397 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CF<sub>3</sub> | 0 |
A-3398 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CHF<sub>2</sub> | 0 |
A-3399 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>F | 0 |
A-3400 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CF<sub>2</sub>Cl | 0 |
A-3401 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-环丙基 | 0 |
A-3402 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-环丁基 | 0 |
A-3403 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-环戊基 | 0 |
A-3404 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-乙烯基 | 0 |
A-3405 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-烯丙基 | 0 |
A-3406 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(丙-1-烯-1-基) | 0 |
A-3407 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(三氟乙烯基) | 0 |
A-3408 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OMe | 0 |
A-3409 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OEt | 0 |
A-3410 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OPr | 0 |
A-3411 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-O(i-Pr) | 0 |
A-3412 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OCF<sub>3</sub> | 0 |
A-3413 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OCHF<sub>2</sub> | 0 |
A-3414 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(环丙基氧基) | 0 |
A-3415 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(环丁基氧基) | 0 |
[表61]
[表62]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3473 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-3474 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-3475 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-3476 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Me,4-OMe | 0 |
A-3477 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Me,5-OMe | 0 |
A-3478 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Me,6-OMe | 0 |
A-3479 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 3-Me,6-OMe | 0 |
A-3480 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 4-Me,2-OMe | 0 |
A-3481 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2,5-OMe<sub>2</sub> | 0 |
A-3482 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2,6-OMe<sub>2</sub> | 0 |
A-3483 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-3484 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-3485 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-3486 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-3487 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-3488 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-环丙基,5-F | 0 |
A-3489 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-环丙基,6-F | 0 |
A-3490 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-环丙基,5-Me | 0 |
A-3491 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-环丙基,6-Me | 0 |
A-3492 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-乙烯基,6-F | 0 |
A-3493 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-乙烯基,6-Me | 0 |
A-3494 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OEt,5-F | 0 |
A-3495 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OEt,6-F | 0 |
A-3496 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OEt,5-Cl | 0 |
A-3497 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OEt,6-Cl | 0 |
A-3498 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OEt,5-Me | 0 |
A-3499 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OEt,6-Me | 0 |
A-3500 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-3501 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-3502 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-3503 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-3504 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(环丙基氧基),5-F | 0 |
A-3505 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(环丙基氧基),6-F | 0 |
A-3506 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(环丙基氧基),5-Me | 0 |
A-3507 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(环丙基氧基),6-Me | 0 |
A-3508 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-SMe,5-F | 0 |
A-3509 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-SMe,6-F | 0 |
A-3510 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-SMe,5-Me | 0 |
A-3511 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-SMe,6-Me | 0 |
A-3512 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)Me,5-F | 0 |
A-3513 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)Me,6-F | 0 |
A-3514 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)Me,5-Me | 0 |
A-3515 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)Me,6-Me | 0 |
A-3516 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-3517 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-3518 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-3519 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-3520 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-3521 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-3522 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-3523 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-3524 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-3525 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-3526 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-3527 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-3528 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-3529 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
[表63]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3530 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-3531 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-3532 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(环丙基硫基),5-F | 0 |
A-3533 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(环丙基硫基),6-F | 0 |
A-3534 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(环丙基硫基),5-Me | 0 |
A-3535 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-(环丙基硫基),6-Me | 0 |
A-3536 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-C(=O)Me,5-F | 0 |
A-3537 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-C(=O)Me,6-F | 0 |
A-3538 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-C(=O)Me,5-Me | 0 |
A-3539 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-C(=O)Me,6-Me | 0 |
A-3540 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-3541 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-3542 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-3543 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-3544 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-3545 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-3546 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-3547 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-3548 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-3549 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-3550 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-3551 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-3552 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-3553 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-3554 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-3555 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-3556 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-3557 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-3558 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-3559 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-3560 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-3561 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-3562 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-3563 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-3564 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-3565 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-3566 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CN,4-F | 0 |
A-3567 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CN,5-F | 0 |
A-3568 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CN,6-F | 0 |
A-3569 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CN,6-Me | 0 |
A-3570 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CN,5-OMe | 0 |
A-3571 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CN,6-OMe | 0 |
A-3572 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 3-CN,6-Me | 0 |
A-3573 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 3-CN,6-OMe | 0 |
A-3574 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 4-CN,2-Me | 0 |
A-3575 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 4-CN,2-OMe | 0 |
A-3576 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-NO<sub>2</sub>,4-F | 0 |
A-3577 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-NO<sub>2</sub>,5-F | 0 |
A-3578 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-NO<sub>2</sub>,6-F | 0 |
A-3579 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-3580 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-3581 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-3582 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-3583 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Me,6-Et | 0 |
A-3584 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-环丙基,6-OMe | 0 |
A-3585 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Me,5-Et | 0 |
A-3586 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2,6-Et<sub>2</sub> | 0 |
[表64]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3587 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-Et,6-F | 0 |
A-3588 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-3589 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-3590 | H | H | H | H | H | O | 四氢呋喃-3-基 | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-3591 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | H | 0 |
A-3592 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-F | 0 |
A-3593 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-Cl | 0 |
A-3594 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-Br | 0 |
A-3595 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OH | 0 |
A-3596 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-Me | 0 |
A-3597 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-Et | 0 |
A-3598 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-Pr | 0 |
A-3599 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CF<sub>3</sub> | 0 |
A-3600 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CHF<sub>2</sub> | 0 |
A-3601 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>F | 0 |
A-3602 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CF<sub>2</sub>Cl | 0 |
A-3603 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-环丙基 | 0 |
A-3604 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-环丁基 | 0 |
A-3605 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-环戊基 | 0 |
A-3606 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-乙烯基 | 0 |
A-3607 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-烯丙基 | 0 |
A-3608 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(丙-1-烯-1-基) | 0 |
A-3609 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(三氟乙烯基) | 0 |
A-3610 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OMe | 0 |
A-3611 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OEt | 0 |
A-3612 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OPr | 0 |
A-3613 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-O(i-Pr) | 0 |
A-3614 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OCF<sub>3</sub> | 0 |
A-3615 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OCHF<sub>2</sub> | 0 |
A-3616 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基氧基) | 0 |
A-3617 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丁基氧基) | 0 |
A-3618 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环戊基氧基) | 0 |
A-3619 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-3620 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环氧乙烷-2-基) | 0 |
A-3621 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-SMe | 0 |
A-3622 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 3-SMe | 0 |
A-3623 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)Me | 0 |
A-3624 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 3-S(=O)Me | 0 |
A-3625 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-3626 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-3627 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-SCF<sub>3</sub> | 0 |
A-3628 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 3-SCF<sub>3</sub> | 0 |
A-3629 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 3-S(=O)CF<sub>3</sub> | 0 |
A-3630 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-3631 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基硫基) | 0 |
A-3632 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基亚磺酰基) | 0 |
A-3633 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基磺酰基) | 0 |
A-3634 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-C(=O)Me | 0 |
A-3635 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
A-3636 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
A-3637 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OH | 0 |
A-3638 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
A-3639 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
A-3640 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
A-3641 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
A-3642 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
A-3643 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(苯甲基氧基) | 0 |
[表65]
[表66]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3701 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OEt,6-Me | 0 |
A-3702 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-3703 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-3704 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-3705 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-3706 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基氧基),5-F | 0 |
A-3707 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基氧基),6-F | 0 |
A-3708 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基氧基),5-Me | 0 |
A-3709 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基氧基),6-Me | 0 |
A-3710 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-SMe,5-F | 0 |
A-3711 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-SMe,6-F | 0 |
A-3712 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-SMe,5-Me | 0 |
A-3713 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-SMe,6-Me | 0 |
A-3714 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)Me,5-F | 0 |
A-3715 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)Me,6-F | 0 |
A-3716 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)Me,5-Me | 0 |
A-3717 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)Me,6-Me | 0 |
A-3718 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-3719 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-3720 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-3721 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-3722 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-3723 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-3724 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-3725 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-3726 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-3727 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-3728 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-3729 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-3730 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-3731 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-3732 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-3733 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-3734 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基硫基),5-F | 0 |
A-3735 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基硫基),6-F | 0 |
A-3736 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基硫基),5-Me | 0 |
A-3737 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-(环丙基硫基),6-Me | 0 |
A-3738 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-C(=O)Me,5-F | 0 |
A-3739 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-C(=O)Me,6-F | 0 |
A-3740 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-C(=O)Me,5-Me | 0 |
A-3741 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-C(=O)Me,6-Me | 0 |
A-3742 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-3743 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-3744 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-3745 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-3746 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-3747 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-3748 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-3749 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-3750 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-3751 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-3752 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-3753 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-3754 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-3755 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-3756 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-3757 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
[表67]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3758 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-3759 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-3760 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-3761 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-3762 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-3763 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-3764 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-3765 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-3766 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-3767 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-3768 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CN,4-F | 0 |
A-3769 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CN,5-F | 0 |
A-3770 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CN,6-F | 0 |
A-3771 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CN,6-Me | 0 |
A-3772 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CN,5-OMe | 0 |
A-3773 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CN,6-OMe | 0 |
A-3774 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 3-CN,6-Me | 0 |
A-3775 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 3-CN,6-OMe | 0 |
A-3776 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 4-CN,2-Me | 0 |
A-3777 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 4-CN,2-OMe | 0 |
A-3778 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-NO<sub>2</sub>,4-F | 0 |
A-3779 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-NO<sub>2</sub>,5-F | 0 |
A-3780 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-NO<sub>2</sub>,6-F | 0 |
A-3781 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-3782 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-3783 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-3784 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-3785 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-Me,6-Et | 0 |
A-3786 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-环丙基,6-OMe | 0 |
A-3787 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-Me,5-Et | 0 |
A-3788 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2,6-Et<sub>2</sub> | 0 |
A-3789 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-Et,6-F | 0 |
A-3790 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-3791 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-3792 | H | H | H | H | H | O | 四氢吡喃-4-基 | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-3793 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | H | 0 |
A-3794 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-F | 0 |
A-3795 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Cl | 0 |
A-3796 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Br | 0 |
A-3797 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OH | 0 |
A-3798 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Me | 0 |
A-3799 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Et | 0 |
A-3800 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Pr | 0 |
A-3801 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CF<sub>3</sub> | 0 |
A-3802 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CHF<sub>2</sub> | 0 |
A-3803 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>F | 0 |
A-3804 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CF<sub>2</sub>Cl | 0 |
A-3805 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-环丙基 | 0 |
A-3806 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-环丁基 | 0 |
A-3807 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-环戊基 | 0 |
A-3808 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-乙烯基 | 0 |
A-3809 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-烯丙基 | 0 |
A-3810 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-(丙-1-烯-1-基) | 0 |
A-3811 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-(三氟乙烯基) | 0 |
A-3812 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OMe | 0 |
A-3813 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OEt | 0 |
A-3814 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OPr | 0 |
[表68]
[表69]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3872 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 3-Cl,6-OMe | 0 |
A-3873 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 4-Cl,2-OMe | 0 |
A-3874 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2,4-Me<sub>2</sub> | 0 |
A-3875 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2,5-Me<sub>2</sub> | 0 |
A-3876 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2,6-Me<sub>2</sub> | 0 |
A-3877 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-3878 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-3879 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-3880 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Me,4-OMe | 0 |
A-3881 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Me,5-OMe | 0 |
A-3882 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Me,6-OMe | 0 |
A-3883 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 3-Me,6-OMe | 0 |
A-3884 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 4-Me,2-OMe | 0 |
A-3885 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2,5-OMe<sub>2</sub> | 0 |
A-3886 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2,6-OMe<sub>2</sub> | 0 |
A-3887 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-3888 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-3889 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-3890 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-3891 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-3892 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-环丙基,5-F | 0 |
A-3893 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-环丙基,6-F | 0 |
A-3894 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-环丙基,5-Me | 0 |
A-3895 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-环丙基,6-Me | 0 |
A-3896 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-乙烯基,6-F | 0 |
A-3897 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-乙烯基,6-Me | 0 |
A-3898 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OEt,5-F | 0 |
A-3899 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OEt,6-F | 0 |
A-3900 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OEt,5-Cl | 0 |
A-3901 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OEt,6-Cl | 0 |
A-3902 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OEt,5-Me | 0 |
A-3903 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OEt,6-Me | 0 |
A-3904 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-3905 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-3906 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-3907 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-3908 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-(环丙基氧基),5-F | 0 |
A-3909 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-(环丙基氧基),6-F | 0 |
A-3910 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-(环丙基氧基),5-Me | 0 |
A-3911 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-(环丙基氧基),6-Me | 0 |
A-3912 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-SMe,5-F | 0 |
A-3913 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-SMe,6-F | 0 |
A-3914 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-SMe,5-Me | 0 |
A-3915 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-SMe,6-Me | 0 |
A-3916 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)Me,5-F | 0 |
A-3917 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)Me,6-F | 0 |
A-3918 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)Me,5-Me | 0 |
A-3919 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)Me,6-Me | 0 |
A-3920 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-3921 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-3922 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-3923 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-3924 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-3925 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-3926 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-3927 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-3928 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
[表70]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3929 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-3930 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-3931 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-3932 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-3933 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-3934 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-3935 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-3936 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-(环丙基硫基),5-F | 0 |
A-3937 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-(环丙基硫基),6-F | 0 |
A-3938 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-(环丙基硫基),5-Me | 0 |
A-3939 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-(环丙基硫基),6-Me | 0 |
A-3940 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-C(=O)Me,5-F | 0 |
A-3941 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-C(=O)Me,6-F | 0 |
A-3942 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-C(=O)Me,5-Me | 0 |
A-3943 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-C(=O)Me,6-Me | 0 |
A-3944 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-3945 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-3946 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-3947 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-3948 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-3949 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-3950 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-3951 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-3952 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-3953 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-3954 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-3955 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-3956 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-3957 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-3958 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-3959 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-3960 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-3961 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-3962 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-3963 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-3964 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-3965 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-3966 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-3967 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-3968 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-3969 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-3970 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CN,4-F | 0 |
A-3971 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CN,5-F | 0 |
A-3972 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CN,6-F | 0 |
A-3973 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CN,6-Me | 0 |
A-3974 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CN,5-OMe | 0 |
A-3975 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CN,6-OMe | 0 |
A-3976 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 3-CN,6-Me | 0 |
A-3977 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 3-CN,6-OMe | 0 |
A-3978 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 4-CN,2-Me | 0 |
A-3979 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 4-CN,2-OMe | 0 |
A-3980 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-NO<sub>2</sub>,4-F | 0 |
A-3981 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-NO<sub>2</sub>,5-F | 0 |
A-3982 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-NO<sub>2</sub>,6-F | 0 |
A-3983 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-3984 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-3985 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-NO<sub>2</sub>,6-Me | 0 |
[表71]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-3986 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-3987 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Me,6-Et | 0 |
A-3988 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-环丙基,6-OMe | 0 |
A-3989 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Me,5-Et | 0 |
A-3990 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2,6-Et<sub>2</sub> | 0 |
A-3991 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-Et,6-F | 0 |
A-3992 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-3993 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-3994 | H | H | H | H | H | O | CH<sub>2</sub>CN | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-3995 | H | H | H | H | H | O | 1-CN-环丙基 | H | H | 0 |
A-3996 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-F | 0 |
A-3997 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-Cl | 0 |
A-3998 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-Br | 0 |
A-3999 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OH | 0 |
A-4000 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-Me | 0 |
A-4001 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-Et | 0 |
A-4002 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-Pr | 0 |
A-4003 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CF<sub>3</sub> | 0 |
A-4004 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CHF<sub>2</sub> | 0 |
A-4005 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>F | 0 |
A-4006 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CF<sub>2</sub>Cl | 0 |
A-4007 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-环丙基 | 0 |
A-4008 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-环丁基 | 0 |
A-4009 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-环戊基 | 0 |
A-4010 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-乙烯基 | 0 |
A-4011 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-烯丙基 | 0 |
A-4012 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(丙-1-烯-1-基) | 0 |
A-4013 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(三氟乙烯基) | 0 |
A-4014 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OMe | 0 |
A-4015 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OEt | 0 |
A-4016 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OPr | 0 |
A-4017 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-O(i-Pr) | 0 |
A-4018 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OCF<sub>3</sub> | 0 |
A-4019 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OCHF<sub>2</sub> | 0 |
A-4020 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基氧基) | 0 |
A-4021 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丁基氧基) | 0 |
A-4022 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环戊基氧基) | 0 |
A-4023 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-4024 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环氧乙烷-2-基) | 0 |
A-4025 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-SMe | 0 |
A-4026 | H | H | H | H | H | O | 1-CN-环丙基 | H | 3-SMe | 0 |
A-4027 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)Me | 0 |
A-4028 | H | H | H | H | H | O | 1-CN-环丙基 | H | 3-S(=O)Me | 0 |
A-4029 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-4030 | H | H | H | H | H | O | 1-CN-环丙基 | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-4031 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-SCF<sub>3</sub> | 0 |
A-4032 | H | H | H | H | H | O | 1-CN-环丙基 | H | 3-SCF<sub>3</sub> | 0 |
A-4033 | H | H | H | H | H | O | 1-CN-环丙基 | H | 3-S(=O)CF<sub>3</sub> | 0 |
A-4034 | H | H | H | H | H | O | 1-CN-环丙基 | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-4035 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基硫基) | 0 |
A-4036 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基亚磺酰基) | 0 |
A-4037 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基磺酰基) | 0 |
A-4038 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-C(=O)Me | 0 |
A-4039 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
A-4040 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
A-4041 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OH | 0 |
A-4042 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
[表72]
[表73]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4100 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OEt,5-F | 0 |
A-4101 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OEt,6-F | 0 |
A-4102 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OEt,5-Cl | 0 |
A-4103 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OEt,6-Cl | 0 |
A-4104 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OEt,5-Me | 0 |
A-4105 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OEt,6-Me | 0 |
A-4106 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-4107 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-4108 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-4109 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-4110 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基氧基),5-F | 0 |
A-4111 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基氧基),6-F | 0 |
A-4112 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基氧基),5-Me | 0 |
A-4113 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基氧基),6-Me | 0 |
A-4114 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-SMe,5-F | 0 |
A-4115 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-SMe,6-F | 0 |
A-4116 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-SMe,5-Me | 0 |
A-4117 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-SMe,6-Me | 0 |
A-4118 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)Me,5-F | 0 |
A-4119 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)Me,6-F | 0 |
A-4120 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)Me,5-Me | 0 |
A-4121 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)Me,6-Me | 0 |
A-4122 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-4123 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-4124 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-4125 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-4126 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-4127 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-4128 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-4129 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-4130 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-4131 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-4132 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-4133 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-4134 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-4135 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-4136 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-4137 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-4138 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基硫基),5-F | 0 |
A-4139 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基硫基),6-F | 0 |
A-4140 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基硫基),5-Me | 0 |
A-4141 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-(环丙基硫基),6-Me | 0 |
A-4142 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-C(=O)Me,5-F | 0 |
A-4143 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-C(=O)Me,6-F | 0 |
A-4144 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-C(=O)Me,5-Me | 0 |
A-4145 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-C(=O)Me,6-Me | 0 |
A-4146 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-4147 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-4148 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-4149 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-4150 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-4151 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-4152 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-4153 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-4154 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-4155 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-4156 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
[表74]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4157 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-4158 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-4159 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-4160 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-4161 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-4162 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-4163 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-4164 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-4165 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-4166 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-4167 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-4168 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-4169 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-4170 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-4171 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-4172 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CN,4-F | 0 |
A-4173 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CN,5-F | 0 |
A-4174 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CN,6-F | 0 |
A-4175 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CN,6-Me | 0 |
A-4176 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CN,5-OMe | 0 |
A-4177 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CN,6-OMe | 0 |
A-4178 | H | H | H | H | H | O | 1-CN-环丙基 | H | 3-CN,6-Me | 0 |
A-4179 | H | H | H | H | H | O | 1-CN-环丙基 | H | 3-CN,6-OMe | 0 |
A-4180 | H | H | H | H | H | O | 1-CN-环丙基 | H | 4-CN,2-Me | 0 |
A-4181 | H | H | H | H | H | O | 1-CN-环丙基 | H | 4-CN,2-OMe | 0 |
A-4182 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-NO<sub>2</sub>,4-F | 0 |
A-4183 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-NO<sub>2</sub>,5-F | 0 |
A-4184 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-NO<sub>2</sub>,6-F | 0 |
A-4185 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-4186 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-4187 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-4188 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-4189 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-Me,6-Et | 0 |
A-4190 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-环丙基,6-OMe | 0 |
A-4191 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-Me,5-Et | 0 |
A-4192 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2,6-Et<sub>2</sub> | 0 |
A-4193 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-Et,6-F | 0 |
A-4194 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-4195 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-4196 | H | H | H | H | H | O | 1-CN-环丙基 | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-4197 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | H | 0 |
A-4198 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-F | 0 |
A-4199 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Cl | 0 |
A-4200 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Br | 0 |
A-4201 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OH | 0 |
A-4202 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Me | 0 |
A-4203 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Et | 0 |
A-4204 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Pr | 0 |
A-4205 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CF<sub>3</sub> | 0 |
A-4206 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CHF<sub>2</sub> | 0 |
A-4207 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>F | 0 |
A-4208 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CF<sub>2</sub>Cl | 0 |
A-4209 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-环丙基 | 0 |
A-4210 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-环丁基 | 0 |
A-4211 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-环戊基 | 0 |
A-4212 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-乙烯基 | 0 |
A-4213 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-烯丙基 | 0 |
[表75]
[表76]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4271 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 3-Cl,6-Me | 0 |
A-4272 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 4-Cl,2-Me | 0 |
A-4273 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Cl,5-CF<sub>3</sub> | 0 |
A-4274 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Cl,6-CF<sub>3</sub> | 0 |
A-4275 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Cl,6-OMe | 0 |
A-4276 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 3-Cl,6-OMe | 0 |
A-4277 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 4-Cl,2-OMe | 0 |
A-4278 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2,4-Me<sub>2</sub> | 0 |
A-4279 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2,5-Me<sub>2</sub> | 0 |
A-4280 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2,6-Me<sub>2</sub> | 0 |
A-4281 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-4282 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-4283 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-4284 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Me,4-OMe | 0 |
A-4285 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Me,5-OMe | 0 |
A-4286 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Me,6-OMe | 0 |
A-4287 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 3-Me,6-OMe | 0 |
A-4288 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 4-Me,2-OMe | 0 |
A-4289 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2,5-OMe<sub>2</sub> | 0 |
A-4290 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2,6-OMe<sub>2</sub> | 0 |
A-4291 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-4292 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-4293 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-4294 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-4295 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-4296 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-环丙基,5-F | 0 |
A-4297 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-环丙基,6-F | 0 |
A-4298 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-环丙基,5-Me | 0 |
A-4299 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-环丙基,6-Me | 0 |
A-4300 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-乙烯基,6-F | 0 |
A-4301 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-乙烯基,6-Me | 0 |
A-4302 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OEt,5-F | 0 |
A-4303 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OEt,6-F | 0 |
A-4304 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OEt,5-Cl | 0 |
A-4305 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OEt,6-Cl | 0 |
A-4306 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OEt,5-Me | 0 |
A-4307 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OEt,6-Me | 0 |
A-4308 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-4309 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-4310 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-4311 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-4312 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-(环丙基氧基),5-F | 0 |
A-4313 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-(环丙基氧基),6-F | 0 |
A-4314 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-(环丙基氧基),5-Me | 0 |
A-4315 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-(环丙基氧基),6-Me | 0 |
A-4316 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-SMe,5-F | 0 |
A-4317 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-SMe,6-F | 0 |
A-4318 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-SMe,5-Me | 0 |
A-4319 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-SMe,6-Me | 0 |
A-4320 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)Me,5-F | 0 |
A-4321 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)Me,6-F | 0 |
A-4322 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)Me,5-Me | 0 |
A-4323 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)Me,6-Me | 0 |
A-4324 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-4325 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-4326 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-4327 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
[表77]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4328 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-4329 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-4330 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-4331 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-4332 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-4333 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-4334 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-4335 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-4336 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-4337 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-4338 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-4339 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-4340 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-(环丙基硫基),5-F | 0 |
A-4341 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-(环丙基硫基),6-F | 0 |
A-4342 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-(环丙基硫基),5-Me | 0 |
A-4343 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-(环丙基硫基),6-Me | 0 |
A-4344 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-C(=O)Me,5-F | 0 |
A-4345 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-C(=O)Me,6-F | 0 |
A-4346 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-C(=O)Me,5-Me | 0 |
A-4347 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-C(=O)Me,6-Me | 0 |
A-4348 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-4349 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-4350 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-4351 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-4352 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-4353 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-4354 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-4355 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-4356 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-4357 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-4358 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-4359 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-4360 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-4361 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-4362 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-4363 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-4364 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-4365 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-4366 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-4367 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-4368 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-4369 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-4370 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-4371 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-4372 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-4373 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-4374 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CN,4-F | 0 |
A-4375 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CN,5-F | 0 |
A-4376 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CN,6-F | 0 |
A-4377 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CN,6-Me | 0 |
A-4378 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CN,5-OMe | 0 |
A-4379 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CN,6-OMe | 0 |
A-4380 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 3-CN,6-Me | 0 |
A-4381 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 3-CN,6-OMe | 0 |
A-4382 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 4-CN,2-Me | 0 |
A-4383 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 4-CN,2-OMe | 0 |
A-4384 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-NO<sub>2</sub>,4-F | 0 |
[表78]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4385 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-NO<sub>2</sub>,5-F | 0 |
A-4386 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-NO<sub>2</sub>,6-F | 0 |
A-4387 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-4388 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-4389 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-4390 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-4391 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Me,6-Et | 0 |
A-4392 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-环丙基,6-OMe | 0 |
A-4393 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Me,5-Et | 0 |
A-4394 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2,6-Et<sub>2</sub> | 0 |
A-4395 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-Et,6-F | 0 |
A-4396 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-4397 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-4398 | H | H | H | H | H | O | CH<sub>2</sub>OH | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-4399 | H | H | H | H | H | O | NH<sub>2</sub> | H | H | 0 |
A-4400 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-F | 0 |
A-4401 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-Cl | 0 |
A-4402 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-Br | 0 |
A-4403 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OH | 0 |
A-4404 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-Me | 0 |
A-4405 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-Et | 0 |
A-4406 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-Pr | 0 |
A-4407 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CF<sub>3</sub> | 0 |
A-4408 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-4409 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-4410 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-4411 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-环丙基 | 0 |
A-4412 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-环丁基 | 0 |
A-4413 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-环戊基 | 0 |
A-4414 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-乙烯基 | 0 |
A-4415 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-烯丙基 | 0 |
A-4416 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-4417 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(三氟乙烯基) | 0 |
A-4418 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OMe | 0 |
A-4419 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OEt | 0 |
A-4420 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OPr | 0 |
A-4421 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-O(i-Pr) | 0 |
A-4422 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OCF<sub>3</sub> | 0 |
A-4423 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OCHF<sub>2</sub> | 0 |
A-4424 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基氧基) | 0 |
A-4425 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丁基氧基) | 0 |
A-4426 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环戊基氧基) | 0 |
A-4427 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-4428 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环氧乙烷-2-基) | 0 |
A-4429 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-SMe | 0 |
A-4430 | H | H | H | H | H | O | NH<sub>2</sub> | H | 3-SMe | 0 |
A-4431 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)Me | 0 |
A-4432 | H | H | H | H | H | O | NH<sub>2</sub> | H | 3-S(=O)Me | 0 |
A-4433 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-4434 | H | H | H | H | H | O | NH<sub>2</sub> | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-4435 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-SCF<sub>3</sub> | 0 |
A-4436 | H | H | H | H | H | O | NH<sub>2</sub> | H | 3-SCF<sub>3</sub> | 0 |
A-4437 | H | H | H | H | H | O | NH<sub>2</sub> | H | 3-S(=O)CF<sub>3</sub> | 0 |
A-4438 | H | H | H | H | H | O | NH<sub>2</sub> | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-4439 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基硫基) | 0 |
A-4440 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基亚磺酰基) | 0 |
A-4441 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基磺酰基) | 0 |
[表79]
[表80]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4499 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-环丙基,6-F | 0 |
A-4500 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-环丙基,5-Me | 0 |
A-4501 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-环丙基,6-Me | 0 |
A-4502 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-乙烯基,6-F | 0 |
A-4503 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-乙烯基,6-Me | 0 |
A-4504 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OEt,5-F | 0 |
A-4505 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OEt,6-F | 0 |
A-4506 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OEt,5-Cl | 0 |
A-4507 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OEt,6-Cl | 0 |
A-4508 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OEt,5-Me | 0 |
A-4509 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OEt,6-Me | 0 |
A-4510 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-4511 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-4512 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-4513 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-4514 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-4515 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-4516 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-4517 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-4518 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-SMe,5-F | 0 |
A-4519 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-SMe,6-F | 0 |
A-4520 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-SMe,5-Me | 0 |
A-4521 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-SMe,6-Me | 0 |
A-4522 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)Me,5-F | 0 |
A-4523 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)Me,6-F | 0 |
A-4524 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-4525 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-4526 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-4527 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-4528 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-4529 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-4530 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-4531 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-4532 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-4533 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-4534 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-4535 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-4536 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-4537 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-4538 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-4539 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-4540 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-4541 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-4542 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-4543 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-4544 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-4545 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-4546 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-C(=O)Me,5-F | 0 |
A-4547 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-C(=O)Me,6-F | 0 |
A-4548 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-4549 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-4550 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-4551 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-4552 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-4553 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-4554 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-4555 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
[表81]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4556 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-4557 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-4558 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-4559 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-4560 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-4561 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-4562 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-4563 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-4564 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-4565 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-4566 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-4567 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-4568 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-4569 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-4570 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-4571 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-4572 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-4573 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-4574 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-4575 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-4576 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CN,4-F | 0 |
A-4577 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CN,5-F | 0 |
A-4578 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CN,6-F | 0 |
A-4579 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CN,6-Me | 0 |
A-4580 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CN,5-OMe | 0 |
A-4581 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CN,6-OMe | 0 |
A-4582 | H | H | H | H | H | O | NH<sub>2</sub> | H | 3-CN,6-Me | 0 |
A-4583 | H | H | H | H | H | O | NH<sub>2</sub> | H | 3-CN,6-OMe | 0 |
A-4584 | H | H | H | H | H | O | NH<sub>2</sub> | H | 4-CN,2-Me | 0 |
A-4585 | H | H | H | H | H | O | NH<sub>2</sub> | H | 4-CN,2-OMe | 0 |
A-4586 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-4587 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-4588 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-4589 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-4590 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-4591 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-4592 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-4593 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-Me,6-Et | 0 |
A-4594 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-环丙基,6-OMe | 0 |
A-4595 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-Me,5-Et | 0 |
A-4596 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-4597 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-Et,6-F | 0 |
A-4598 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-4599 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-4600 | H | H | H | H | H | O | NH<sub>2</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-4601 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | H | 0 |
A-4602 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-F | 0 |
A-4603 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Cl | 0 |
A-4604 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Br | 0 |
A-4605 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OH | 0 |
A-4606 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Me | 0 |
A-4607 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Et | 0 |
A-4608 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Pr | 0 |
A-4609 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CF<sub>3</sub> | 0 |
A-4610 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-4611 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-4612 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
[表82]
[表83]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4670 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 4-F,2-Me | 0 |
A-4671 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-F,6-OMe | 0 |
A-4672 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 3-F,6-OMe | 0 |
A-4673 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2,6-Cl<sub>2</sub> | 0 |
A-4674 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Cl,6-Me | 0 |
A-4675 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 3-Cl,6-Me | 0 |
A-4676 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 4-Cl,2-Me | 0 |
A-4677 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Cl,5-CF<sub>3</sub> | 0 |
A-4678 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Cl,6-CF<sub>3</sub> | 0 |
A-4679 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Cl,6-OMe | 0 |
A-4680 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 3-Cl,6-OMe | 0 |
A-4681 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 4-Cl,2-OMe | 0 |
A-4682 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2,4-Me<sub>2</sub> | 0 |
A-4683 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2,5-Me<sub>2</sub> | 0 |
A-4684 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2,6-Me<sub>2</sub> | 0 |
A-4685 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-4686 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-4687 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-4688 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Me,4-OMe | 0 |
A-4689 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Me,5-OMe | 0 |
A-4690 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Me,6-OMe | 0 |
A-4691 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 3-Me,6-OMe | 0 |
A-4692 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 4-Me,2-OMe | 0 |
A-4693 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2,5-OMe<sub>2</sub> | 0 |
A-4694 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2,6-OMe<sub>2</sub> | 0 |
A-4695 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-4696 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-4697 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-4698 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-4699 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-4700 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-环丙基,5-F | 0 |
A-4701 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-环丙基,6-F | 0 |
A-4702 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-环丙基,5-Me | 0 |
A-4703 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-环丙基,6-Me | 0 |
A-4704 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-乙烯基,6-F | 0 |
A-4705 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-乙烯基,6-Me | 0 |
A-4706 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OEt,5-F | 0 |
A-4707 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OEt,6-F | 0 |
A-4708 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OEt,5-Cl | 0 |
A-4709 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OEt,6-Cl | 0 |
A-4710 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OEt,5-Me | 0 |
A-4711 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OEt,6-Me | 0 |
A-4712 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-4713 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-4714 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-4715 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-4716 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-4717 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-4718 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-4719 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-4720 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-4721 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-4722 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-4723 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-4724 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-4725 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-4726 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
[表84]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4727 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-4728 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-4729 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-4730 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-4731 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-4732 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-4733 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-4734 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-4735 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-4736 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-4737 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-4738 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-4739 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-4740 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-4741 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-4742 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-4743 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-4744 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-4745 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-4746 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-4747 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-4748 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-4749 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-4750 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-4751 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-4752 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-4753 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-4754 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-4755 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-4756 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-4757 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-4758 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-4759 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-4760 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-4761 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-4762 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-4763 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-4764 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-4765 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-4766 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-4767 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-4768 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-4769 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-4770 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-4771 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-4772 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-4773 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-4774 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-4775 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-4776 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-4777 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-4778 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-4779 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-4780 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-4781 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-4782 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-4783 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
[表85]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4784 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-4785 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-4786 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-4787 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-4788 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-4789 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-4790 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-4791 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-4792 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-4793 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-4794 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-4795 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-4796 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-4797 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-4798 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-4799 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-4800 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-4801 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-4802 | H | H | H | H | H | O | C(=O)CH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-4803 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | H | 0 |
A-4804 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-F | 0 |
A-4805 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-Cl | 0 |
A-4806 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-Br | 0 |
A-4807 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OH | 0 |
A-4808 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-Me | 0 |
A-4809 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-Et | 0 |
A-4810 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-Pr | 0 |
A-4811 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CF<sub>3</sub> | 0 |
A-4812 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-4813 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-4814 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-4815 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-环丙基 | 0 |
A-4816 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-环丁基 | 0 |
A-4817 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-环戊基 | 0 |
A-4818 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-乙烯基 | 0 |
A-4819 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-烯丙基 | 0 |
A-4820 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-4821 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(三氟乙烯基) | 0 |
A-4822 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OMe | 0 |
A-4823 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OEt | 0 |
A-4824 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OPr | 0 |
A-4825 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-O(i-Pr) | 0 |
A-4826 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OCF<sub>3</sub> | 0 |
A-4827 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub> | 0 |
A-4828 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环丙基氧基) | 0 |
A-4829 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环丁基氧基) | 0 |
A-4830 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环戊基氧基) | 0 |
A-4831 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-4832 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环氧乙烷-2-基) | 0 |
A-4833 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-SMe | 0 |
A-4834 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 3-SMe | 0 |
A-4835 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)Me | 0 |
A-4836 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 3-S(=O)Me | 0 |
A-4837 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-4838 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-4839 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-SCF<sub>3</sub> | 0 |
A-4840 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 3-SCF<sub>3</sub> | 0 |
[表86]
[表87]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4898 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-4899 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-4900 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-4901 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-4902 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-环丙基,5-F | 0 |
A-4903 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-环丙基,6-F | 0 |
A-4904 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-环丙基,5-Me | 0 |
A-4905 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-环丙基,6-Me | 0 |
A-4906 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-乙烯基,6-F | 0 |
A-4907 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-乙烯基,6-Me | 0 |
A-4908 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OEt,5-F | 0 |
A-4909 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OEt,6-F | 0 |
A-4910 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OEt,5-Cl | 0 |
A-4911 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OEt,6-Cl | 0 |
A-4912 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OEt,5-Me | 0 |
A-4913 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OEt,6-Me | 0 |
A-4914 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-4915 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-4916 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-4917 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-4918 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-4919 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-4920 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-4921 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-4922 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-4923 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-4924 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-4925 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-4926 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-4927 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-4928 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-4929 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-4930 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-4931 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-4932 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-4933 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-4934 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-4935 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-4936 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-4937 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-4938 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-4939 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-4940 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-4941 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-4942 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-4943 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-4944 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-4945 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-4946 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-4947 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-4948 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-4949 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-4950 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-4951 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-4952 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-4953 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-4954 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
[表88]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-4955 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-4956 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-4957 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-4958 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-4959 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-4960 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-4961 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-4962 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-4963 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-4964 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-4965 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-4966 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-4967 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-4968 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-4969 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-4970 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-4971 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-4972 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-4973 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-4974 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-4975 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-4976 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-4977 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-4978 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-4979 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-4980 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-4981 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-4982 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-4983 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-4984 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-4985 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-4986 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-4987 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-4988 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-4989 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-4990 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-4991 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-4992 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-4993 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-4994 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-4995 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-4996 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-4997 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-4998 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-4999 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-5000 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-5001 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-5002 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-5003 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-5004 | H | H | H | H | H | O | C(=O)CH<sub>2</sub>OCH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-5005 | H | H | H | H | H | O | C(=O)环丙基 | H | H | 0 |
A-5006 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-F | 0 |
A-5007 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Cl | 0 |
A-5008 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Br | 0 |
A-5009 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OH | 0 |
A-5010 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Me | 0 |
A-5011 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Et | 0 |
[表89]
[表90]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5069 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CN | 0 |
A-5070 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NO<sub>2</sub> | 0 |
A-5071 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-F,6-Cl | 0 |
A-5072 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-F,6-Me | 0 |
A-5073 | H | H | H | H | H | O | C(=O)环丙基 | H | 3-F,6-Me | 0 |
A-5074 | H | H | H | H | H | O | C(=O)环丙基 | H | 4-F,2-Me | 0 |
A-5075 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-F,6-OMe | 0 |
A-5076 | H | H | H | H | H | O | C(=O)环丙基 | H | 3-F,6-OMe | 0 |
A-5077 | H | H | H | H | H | O | C(=O)环丙基 | H | 2,6-Cl<sub>2</sub> | 0 |
A-5078 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Cl,6-Me | 0 |
A-5079 | H | H | H | H | H | O | C(=O)环丙基 | H | 3-Cl,6-Me | 0 |
A-5080 | H | H | H | H | H | O | C(=O)环丙基 | H | 4-Cl,2-Me | 0 |
A-5081 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Cl,5-CF<sub>3</sub> | 0 |
A-5082 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Cl,6-CF<sub>3</sub> | 0 |
A-5083 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Cl,6-OMe | 0 |
A-5084 | H | H | H | H | H | O | C(=O)环丙基 | H | 3-Cl,6-OMe | 0 |
A-5085 | H | H | H | H | H | O | C(=O)环丙基 | H | 4-Cl,2-OMe | 0 |
A-5086 | H | H | H | H | H | O | C(=O)环丙基 | H | 2,4-Me<sub>2</sub> | 0 |
A-5087 | H | H | H | H | H | O | C(=O)环丙基 | H | 2,5-Me<sub>2</sub> | 0 |
A-5088 | H | H | H | H | H | O | C(=O)环丙基 | H | 2,6-Me<sub>2</sub> | 0 |
A-5089 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-5090 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-5091 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-5092 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Me,4-OMe | 0 |
A-5093 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Me,5-OMe | 0 |
A-5094 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Me,6-OMe | 0 |
A-5095 | H | H | H | H | H | O | C(=O)环丙基 | H | 3-Me,6-OMe | 0 |
A-5096 | H | H | H | H | H | O | C(=O)环丙基 | H | 4-Me,2-OMe | 0 |
A-5097 | H | H | H | H | H | O | C(=O)环丙基 | H | 2,5-OMe<sub>2</sub> | 0 |
A-5098 | H | H | H | H | H | O | C(=O)环丙基 | H | 2,6-OMe<sub>2</sub> | 0 |
A-5099 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-5100 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-5101 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-5102 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-5103 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-5104 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-环丙基,5-F | 0 |
A-5105 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-环丙基,6-F | 0 |
A-5106 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-环丙基,5-Me | 0 |
A-5107 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-环丙基,6-Me | 0 |
A-5108 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-乙烯基,6-F | 0 |
A-5109 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-乙烯基,6-Me | 0 |
A-5110 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OEt,5-F | 0 |
A-5111 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OEt,6-F | 0 |
A-5112 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OEt,5-Cl | 0 |
A-5113 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OEt,6-Cl | 0 |
A-5114 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OEt,5-Me | 0 |
A-5115 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OEt,6-Me | 0 |
A-5116 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-5117 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-5118 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-5119 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-5120 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-(环丙基氧基),5-F | 0 |
A-5121 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-(环丙基氧基),6-F | 0 |
A-5122 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-(环丙基氧基),5-Me | 0 |
A-5123 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-(环丙基氧基),6-Me | 0 |
A-5124 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-SMe,5-F | 0 |
A-5125 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-SMe,6-F | 0 |
[表91]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5126 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-SMe,5-Me | 0 |
A-5127 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-SMe,6-Me | 0 |
A-5128 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)Me,5-F | 0 |
A-5129 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)Me,6-F | 0 |
A-5130 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)Me,5-Me | 0 |
A-5131 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)Me,6-Me | 0 |
A-5132 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-5133 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-5134 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-5135 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-5136 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-5137 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-5138 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-5139 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-5140 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-5141 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-5142 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-5143 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-5144 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-5145 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-5146 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-5147 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-5148 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-(环丙基硫基),5-F | 0 |
A-5149 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-(环丙基硫基),6-F | 0 |
A-5150 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-(环丙基硫基),5-Me | 0 |
A-5151 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-(环丙基硫基),6-Me | 0 |
A-5152 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-C(=O)Me,5-F | 0 |
A-5153 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-C(=O)Me,6-F | 0 |
A-5154 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-C(=O)Me,5-Me | 0 |
A-5155 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-C(=O)Me,6-Me | 0 |
A-5156 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-5157 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-5158 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-5159 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-5160 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-5161 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-5162 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-5163 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-5164 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-5165 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-5166 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-5167 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-5168 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-5169 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-5170 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-5171 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-5172 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-5173 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-5174 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-5175 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-5176 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-5177 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-5178 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-5179 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-5180 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-5181 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-5182 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CN,4-F | 0 |
[表92]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5183 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CN,5-F | 0 |
A-5184 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CN,6-F | 0 |
A-5185 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CN,6-Me | 0 |
A-5186 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CN,5-OMe | 0 |
A-5187 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CN,6-OMe | 0 |
A-5188 | H | H | H | H | H | O | C(=O)环丙基 | H | 3-CN,6-Me | 0 |
A-5189 | H | H | H | H | H | O | C(=O)环丙基 | H | 3-CN,6-OMe | 0 |
A-5190 | H | H | H | H | H | O | C(=O)环丙基 | H | 4-CN,2-Me | 0 |
A-5191 | H | H | H | H | H | O | C(=O)环丙基 | H | 4-CN,2-OMe | 0 |
A-5192 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NO<sub>2</sub>,4-F | 0 |
A-5193 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NO<sub>2</sub>,5-F | 0 |
A-5194 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NO<sub>2</sub>,6-F | 0 |
A-5195 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-5196 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-5197 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-5198 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-5199 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Me,6-Et | 0 |
A-5200 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-环丙基,6-OMe | 0 |
A-5201 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Me,5-Et | 0 |
A-5202 | H | H | H | H | H | O | C(=O)环丙基 | H | 2,6-Et<sub>2</sub> | 0 |
A-5203 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-Et,6-F | 0 |
A-5204 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-5205 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-5206 | H | H | H | H | H | O | C(=O)环丙基 | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-5207 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | H | 0 |
A-5208 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-F | 0 |
A-5209 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-Cl | 0 |
A-5210 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-Br | 0 |
A-5211 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OH | 0 |
A-5212 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-Me | 0 |
A-5213 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-Et | 0 |
A-5214 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-Pr | 0 |
A-5215 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CF<sub>3</sub> | 0 |
A-5216 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-5217 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-5218 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-5219 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-环丙基 | 0 |
A-5220 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-环丁基 | 0 |
A-5221 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-环戊基 | 0 |
A-5222 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-乙烯基 | 0 |
A-5223 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-烯丙基 | 0 |
A-5224 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-5225 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(三氟乙烯基) | 0 |
A-5226 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OMe | 0 |
A-5227 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OEt | 0 |
A-5228 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OPr | 0 |
A-5229 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-O(i-Pr) | 0 |
A-5230 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OCF<sub>3</sub> | 0 |
A-5231 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub> | 0 |
A-5232 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环丙基氧基) | 0 |
A-5233 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环丁基氧基) | 0 |
A-5234 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环戊基氧基) | 0 |
A-5235 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-5236 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环氧乙烷-2-基) | 0 |
A-5237 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-SMe | 0 |
A-5238 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 3-SMe | 0 |
A-5239 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)Me | 0 |
[表93]
[表94]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5297 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 3-Me,6-OMe | 0 |
A-5298 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 4-Me,2-OMe | 0 |
A-5299 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2,5-OMe<sub>2</sub> | 0 |
A-5300 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2,6-OMe<sub>2</sub> | 0 |
A-5301 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-5302 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-5303 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-5304 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-5305 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-5306 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-环丙基,5-F | 0 |
A-5307 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-环丙基,6-F | 0 |
A-5308 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-环丙基,5-Me | 0 |
A-5309 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-环丙基,6-Me | 0 |
A-5310 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-乙烯基,6-F | 0 |
A-5311 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-乙烯基,6-Me | 0 |
A-5312 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OEt,5-F | 0 |
A-5313 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OEt,6-F | 0 |
A-5314 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OEt,5-Cl | 0 |
A-5315 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OEt,6-Cl | 0 |
A-5316 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OEt,5-Me | 0 |
A-5317 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OEt,6-Me | 0 |
A-5318 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-5319 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-5320 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-5321 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-5322 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-5323 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-5324 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-5325 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-5326 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-5327 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-5328 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-5329 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-5330 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-5331 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-5332 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-5333 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-5334 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-5335 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-5336 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-5337 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-5338 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-5339 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-5340 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-5341 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-5342 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-5343 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-5344 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-5345 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-5346 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-5347 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-5348 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-5349 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-5350 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-5351 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-5352 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-5353 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
[表95]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5354 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-5355 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-5356 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-5357 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-5358 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-5359 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-5360 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-5361 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-5362 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-5363 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-5364 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-5365 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-5366 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-5367 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-5368 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-5369 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-5370 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-5371 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-5372 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-5373 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-5374 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-5375 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-5376 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-5377 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-5378 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-5379 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-5380 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-5381 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-5382 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-5383 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-5384 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-5385 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-5386 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-5387 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-5388 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-5389 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-5390 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-5391 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-5392 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-5393 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-5394 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-5395 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-5396 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-5397 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-5398 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-5399 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-5400 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-5401 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-5402 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-5403 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-5404 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-5405 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-5406 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-5407 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-5408 | H | H | H | H | H | O | C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-5409 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | H | 0 |
A-5410 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-F | 0 |
[表96]
[表97]
[表98]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5525 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-5526 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-5527 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-5528 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-5529 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-5530 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-5531 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-5532 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-5533 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-5534 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-5535 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-5536 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-5537 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-5538 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-5539 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-5540 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-5541 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-5542 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-5543 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-5544 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-5545 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-5546 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-5547 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-5548 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-5549 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-5550 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-5551 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-5552 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-5553 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-5554 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-5555 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-5556 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-5557 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-5558 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-5559 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-5560 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-5561 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-5562 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-5563 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-5564 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-5565 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-5566 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-5567 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-5568 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-5569 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-5570 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-5571 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-5572 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-5573 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-5574 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-5575 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-5576 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-5577 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-5578 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-5579 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-5580 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-5581 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
[表99]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5582 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-5583 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-5584 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-5585 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-5586 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-5587 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-5588 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-5589 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-5590 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-5591 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-5592 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-5593 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-5594 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-5595 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-5596 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-5597 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-5598 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-5599 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-5600 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-5601 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-5602 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-5603 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-5604 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-5605 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-5606 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-5607 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-5608 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-5609 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-5610 | H | H | H | H | H | O | C(=O)OCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-5611 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | H | 0 |
A-5612 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-F | 0 |
A-5613 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Cl | 0 |
A-5614 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Br | 0 |
A-5615 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OH | 0 |
A-5616 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me | 0 |
A-5617 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Et | 0 |
A-5618 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Pr | 0 |
A-5619 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CF<sub>3</sub> | 0 |
A-5620 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-5621 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-5622 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-5623 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基 | 0 |
A-5624 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丁基 | 0 |
A-5625 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环戊基 | 0 |
A-5626 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-乙烯基 | 0 |
A-5627 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-烯丙基 | 0 |
A-5628 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-5629 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(三氟乙烯基) | 0 |
A-5630 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OMe | 0 |
A-5631 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt | 0 |
A-5632 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OPr | 0 |
A-5633 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-O(i-Pr) | 0 |
A-5634 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCF<sub>3</sub> | 0 |
A-5635 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub> | 0 |
A-5636 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基) | 0 |
A-5637 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丁基氧基) | 0 |
A-5638 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环戊基氧基) | 0 |
[表100]
[表101]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5696 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-5697 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-5698 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,4-OMe | 0 |
A-5699 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,5-OMe | 0 |
A-5700 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,6-OMe | 0 |
A-5701 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-Me,6-OMe | 0 |
A-5702 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 4-Me,2-OMe | 0 |
A-5703 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2,5-OMe<sub>2</sub> | 0 |
A-5704 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2,6-OMe<sub>2</sub> | 0 |
A-5705 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-5706 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-5707 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-5708 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-5709 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-5710 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,5-F | 0 |
A-5711 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,6-F | 0 |
A-5712 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,5-Me | 0 |
A-5713 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,6-Me | 0 |
A-5714 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-乙烯基,6-F | 0 |
A-5715 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-乙烯基,6-Me | 0 |
A-5716 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-F | 0 |
A-5717 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-F | 0 |
A-5718 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-Cl | 0 |
A-5719 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-Cl | 0 |
A-5720 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-Me | 0 |
A-5721 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-Me | 0 |
A-5722 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-5723 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-5724 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-5725 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-5726 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-5727 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-5728 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-5729 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-5730 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,5-F | 0 |
A-5731 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,6-F | 0 |
A-5732 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,5-Me | 0 |
A-5733 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,6-Me | 0 |
A-5734 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,5-F | 0 |
A-5735 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,6-F | 0 |
A-5736 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-5737 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-5738 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-5739 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-5740 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-5741 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-5742 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-5743 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-5744 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-5745 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-5746 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-5747 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-5748 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-5749 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-5750 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-5751 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-5752 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
[表102]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5753 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-5754 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-5755 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-5756 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-5757 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-5758 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,5-F | 0 |
A-5759 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,6-F | 0 |
A-5760 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-5761 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-5762 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-5763 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-5764 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-5765 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-5766 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-5767 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-5768 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-5769 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-5770 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-5771 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-5772 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-5773 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-5774 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-5775 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-5776 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-5777 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-5778 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-5779 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-5780 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-5781 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-5782 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-5783 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-5784 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-5785 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-5786 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-5787 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-5788 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,4-F | 0 |
A-5789 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,5-F | 0 |
A-5790 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-F | 0 |
A-5791 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-Me | 0 |
A-5792 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,5-OMe | 0 |
A-5793 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-OMe | 0 |
A-5794 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-CN,6-Me | 0 |
A-5795 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-CN,6-OMe | 0 |
A-5796 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 4-CN,2-Me | 0 |
A-5797 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 4-CN,2-OMe | 0 |
A-5798 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-5799 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-5800 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-5801 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-5802 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-5803 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-5804 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-5805 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,6-Et | 0 |
A-5806 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,6-OMe | 0 |
A-5807 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,5-Et | 0 |
A-5808 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-5809 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Et,6-F | 0 |
[表103]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5810 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-5811 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-5812 | H | H | H | H | H | O | C(=O)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-5813 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | H | 0 |
A-5814 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-F | 0 |
A-5815 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-Cl | 0 |
A-5816 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-Br | 0 |
A-5817 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OH | 0 |
A-5818 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-Me | 0 |
A-5819 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-Et | 0 |
A-5820 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-Pr | 0 |
A-5821 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CF<sub>3</sub> | 0 |
A-5822 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CHF<sub>2</sub> | 0 |
A-5823 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>F | 0 |
A-5824 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CF<sub>2</sub>Cl | 0 |
A-5825 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-环丙基 | 0 |
A-5826 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-环丁基 | 0 |
A-5827 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-环戊基 | 0 |
A-5828 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-乙烯基 | 0 |
A-5829 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-烯丙基 | 0 |
A-5830 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(丙-1-烯-1-基) | 0 |
A-5831 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(三氟乙烯基) | 0 |
A-5832 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OMe | 0 |
A-5833 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OEt | 0 |
A-5834 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OPr | 0 |
A-5835 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-O(i-Pr) | 0 |
A-5836 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OCF<sub>3</sub> | 0 |
A-5837 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OCHF<sub>2</sub> | 0 |
A-5838 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基氧基) | 0 |
A-5839 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丁基氧基) | 0 |
A-5840 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环戊基氧基) | 0 |
A-5841 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-5842 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环氧乙烷-2-基) | 0 |
A-5843 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-SMe | 0 |
A-5844 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 3-SMe | 0 |
A-5845 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)Me | 0 |
A-5846 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 3-S(=O)Me | 0 |
A-5847 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-5848 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-5849 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-SCF<sub>3</sub> | 0 |
A-5850 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 3-SCF<sub>3</sub> | 0 |
A-5851 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 3-S(=O)CF<sub>3</sub> | 0 |
A-5852 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-5853 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基硫基) | 0 |
A-5854 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基亚磺酰基) | 0 |
A-5855 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基磺酰基) | 0 |
A-5856 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-C(=O)Me | 0 |
A-5857 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
A-5858 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
A-5859 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OH | 0 |
A-5860 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
A-5861 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
A-5862 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
A-5863 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
A-5864 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
A-5865 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(苯甲基氧基) | 0 |
A-5866 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NH2 | 0 |
[表104]
[表105]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5924 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-5925 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-5926 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-5927 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-5928 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基氧基),5-F | 0 |
A-5929 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基氧基),6-F | 0 |
A-5930 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基氧基),5-Me | 0 |
A-5931 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基氧基),6-Me | 0 |
A-5932 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-SMe,5-F | 0 |
A-5933 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-SMe,6-F | 0 |
A-5934 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-SMe,5-Me | 0 |
A-5935 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-SMe,6-Me | 0 |
A-5936 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)Me,5-F | 0 |
A-5937 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)Me,6-F | 0 |
A-5938 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)Me,5-Me | 0 |
A-5939 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)Me,6-Me | 0 |
A-5940 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-5941 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-5942 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-5943 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-5944 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-5945 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-5946 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-5947 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-5948 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-5949 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-5950 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-5951 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-5952 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-5953 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-5954 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-5955 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-5956 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基硫基),5-F | 0 |
A-5957 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基硫基),6-F | 0 |
A-5958 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基硫基),5-Me | 0 |
A-5959 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-(环丙基硫基),6-Me | 0 |
A-5960 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-C(=O)Me,5-F | 0 |
A-5961 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-C(=O)Me,6-F | 0 |
A-5962 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-C(=O)Me,5-Me | 0 |
A-5963 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-C(=O)Me,6-Me | 0 |
A-5964 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-5965 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-5966 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-5967 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-5968 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-5969 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-5970 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-5971 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-5972 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-5973 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-5974 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-5975 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-5976 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-5977 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-5978 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-5979 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-5980 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
[表106]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-5981 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-5982 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-5983 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-5984 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-5985 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-5986 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-5987 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-5988 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-5989 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-5990 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CN,4-F | 0 |
A-5991 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CN,5-F | 0 |
A-5992 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CN,6-F | 0 |
A-5993 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CN,6-Me | 0 |
A-5994 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CN,5-OMe | 0 |
A-5995 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CN,6-OMe | 0 |
A-5996 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 3-CN,6-Me | 0 |
A-5997 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 3-CN,6-OMe | 0 |
A-5998 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 4-CN,2-Me | 0 |
A-5999 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 4-CN,2-OMe | 0 |
A-6000 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NO<sub>2</sub>,4-F | 0 |
A-6001 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NO<sub>2</sub>,5-F | 0 |
A-6002 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NO<sub>2</sub>,6-F | 0 |
A-6003 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-6004 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-6005 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-6006 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-6007 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-Me,6-Et | 0 |
A-6008 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-环丙基,6-OMe | 0 |
A-6009 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-Me,5-Et | 0 |
A-6010 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2,6-Et<sub>2</sub> | 0 |
A-6011 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-Et,6-F | 0 |
A-6012 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-6013 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-6014 | H | H | H | H | H | O | C(=O)(4-Cl)Ph | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-6015 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | H | 0 |
A-6016 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-F | 0 |
A-6017 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Cl | 0 |
A-6018 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Br | 0 |
A-6019 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OH | 0 |
A-6020 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Me | 0 |
A-6021 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Et | 0 |
A-6022 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Pr | 0 |
A-6023 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CF<sub>3</sub> | 0 |
A-6024 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-6025 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-6026 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-6027 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-环丙基 | 0 |
A-6028 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-环丁基 | 0 |
A-6029 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-环戊基 | 0 |
A-6030 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-乙烯基 | 0 |
A-6031 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-烯丙基 | 0 |
A-6032 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-6033 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-(三氟乙烯基) | 0 |
A-6034 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OMe | 0 |
A-6035 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OEt | 0 |
A-6036 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OPr | 0 |
A-6037 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-O(i-Pr) | 0 |
[表107]
[表108]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6095 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 4-Cl,2-OMe | 0 |
A-6096 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2,4-Me<sub>2</sub> | 0 |
A-6097 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2,5-Me<sub>2</sub> | 0 |
A-6098 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2,6-Me<sub>2</sub> | 0 |
A-6099 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-6100 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-6101 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-6102 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Me,4-OMe | 0 |
A-6103 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Me,5-OMe | 0 |
A-6104 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Me,6-OMe | 0 |
A-6105 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 3-Me,6-OMe | 0 |
A-6106 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 4-Me,2-OMe | 0 |
A-6107 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2,5-OMe<sub>2</sub> | 0 |
A-6108 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2,6-OMe<sub>2</sub> | 0 |
A-6109 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-6110 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-6111 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-6112 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-6113 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-6114 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-环丙基,5-F | 0 |
A-6115 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-环丙基,6-F | 0 |
A-6116 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-环丙基,5-Me | 0 |
A-6117 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-环丙基,6-Me | 0 |
A-6118 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-乙烯基,6-F | 0 |
A-6119 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-乙烯基,6-Me | 0 |
A-6120 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OEt,5-F | 0 |
A-6121 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OEt,6-F | 0 |
A-6122 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OEt,5-Cl | 0 |
A-6123 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OEt,6-Cl | 0 |
A-6124 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OEt,5-Me | 0 |
A-6125 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OEt,6-Me | 0 |
A-6126 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-6127 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-6128 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-6129 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-6130 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-6131 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-6132 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-6133 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-6134 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-6135 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-6136 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-6137 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-6138 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-6139 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-6140 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-6141 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-6142 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-6143 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-6144 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-6145 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-6146 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-6147 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-6148 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-6149 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-6150 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-6151 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
[表109]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6152 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-6153 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-6154 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-6155 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-6156 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-6157 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-6158 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-6159 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-6160 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-6161 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-6162 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-6163 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-6164 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-6165 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-6166 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-6167 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-6168 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-6169 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-6170 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-6171 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-6172 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-6173 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-6174 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-6175 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-6176 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-6177 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-6178 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-6179 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-6180 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-6181 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-6182 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-6183 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-6184 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-6185 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-6186 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-6187 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-6188 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-6189 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-6190 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-6191 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-6192 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-6193 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-6194 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-6195 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-6196 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-6197 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-6198 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-6199 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-6200 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-6201 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-6202 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-6203 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-6204 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-6205 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-6206 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-6207 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-6208 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
[表110]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6209 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-6210 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-6211 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-6212 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-6213 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-6214 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-6215 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-6216 | H | H | H | H | H | O | C(=S)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-6217 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | H | 0 |
A-6218 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-F | 0 |
A-6219 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Cl | 0 |
A-6220 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Br | 0 |
A-6221 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OH | 0 |
A-6222 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me | 0 |
A-6223 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Et | 0 |
A-6224 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Pr | 0 |
A-6225 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CF<sub>3</sub> | 0 |
A-6226 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-6227 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-6228 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-6229 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基 | 0 |
A-6230 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丁基 | 0 |
A-6231 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环戊基 | 0 |
A-6232 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-乙烯基 | 0 |
A-6233 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-烯丙基 | 0 |
A-6234 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-6235 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(三氟乙烯基) | 0 |
A-6236 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OMe | 0 |
A-6237 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt | 0 |
A-6238 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OPr | 0 |
A-6239 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-O(i-Pr) | 0 |
A-6240 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCF<sub>3</sub> | 0 |
A-6241 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub> | 0 |
A-6242 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基) | 0 |
A-6243 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丁基氧基) | 0 |
A-6244 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环戊基氧基) | 0 |
A-6245 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-6246 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环氧乙烷-2-基) | 0 |
A-6247 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe | 0 |
A-6248 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-SMe | 0 |
A-6249 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me | 0 |
A-6250 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-S(=O)Me | 0 |
A-6251 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-6252 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-6253 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub> | 0 |
A-6254 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-SCF<sub>3</sub> | 0 |
A-6255 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-S(=O)CF<sub>3</sub> | 0 |
A-6256 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-6257 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基) | 0 |
A-6258 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基亚磺酰基) | 0 |
A-6259 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基磺酰基) | 0 |
A-6260 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me | 0 |
A-6261 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
A-6262 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
A-6263 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH | 0 |
A-6264 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
A-6265 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
[表111]
[表112]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6323 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-F | 0 |
A-6324 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-Cl | 0 |
A-6325 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-Cl | 0 |
A-6326 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-Me | 0 |
A-6327 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-Me | 0 |
A-6328 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-6329 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-6330 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-6331 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-6332 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-6333 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-6334 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-6335 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-6336 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,5-F | 0 |
A-6337 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,6-F | 0 |
A-6338 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,5-Me | 0 |
A-6339 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,6-Me | 0 |
A-6340 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,5-F | 0 |
A-6341 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,6-F | 0 |
A-6342 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-6343 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-6344 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-6345 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-6346 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-6347 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-6348 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-6349 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-6350 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-6351 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-6352 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-6353 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-6354 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-6355 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-6356 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-6357 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-6358 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-6359 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-6360 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-6361 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-6362 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-6363 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-6364 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,5-F | 0 |
A-6365 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,6-F | 0 |
A-6366 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-6367 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-6368 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-6369 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-6370 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-6371 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-6372 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-6373 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-6374 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-6375 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-6376 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-6377 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-6378 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-6379 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
[表113]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6380 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-6381 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-6382 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-6383 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-6384 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-6385 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-6386 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-6387 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-6388 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-6389 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-6390 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-6391 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-6392 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-6393 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-6394 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,4-F | 0 |
A-6395 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,5-F | 0 |
A-6396 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-F | 0 |
A-6397 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-Me | 0 |
A-6398 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,5-OMe | 0 |
A-6399 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-OMe | 0 |
A-6400 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-CN,6-Me | 0 |
A-6401 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 3-CN,6-OMe | 0 |
A-6402 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 4-CN,2-Me | 0 |
A-6403 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 4-CN,2-OMe | 0 |
A-6404 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-6405 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-6406 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-6407 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-6408 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-6409 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-6410 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-6411 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,6-Et | 0 |
A-6412 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,6-OMe | 0 |
A-6413 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,5-Et | 0 |
A-6414 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-6415 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Et,6-F | 0 |
A-6416 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-6417 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-6418 | H | H | H | H | H | O | C(=S)N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-6419 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | H | 0 |
A-6420 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-F | 0 |
A-6421 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Cl | 0 |
A-6422 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Br | 0 |
A-6423 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OH | 0 |
A-6424 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Me | 0 |
A-6425 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Et | 0 |
A-6426 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Pr | 0 |
A-6427 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CF<sub>3</sub> | 0 |
A-6428 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-6429 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-6430 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-6431 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基 | 0 |
A-6432 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-环丁基 | 0 |
A-6433 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-环戊基 | 0 |
A-6434 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-乙烯基 | 0 |
A-6435 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-烯丙基 | 0 |
A-6436 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-(丙-1-烯-1-基) | 0 |
[表114]
[表115]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6494 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 4-Cl,2-Me | 0 |
A-6495 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Cl,5-CF<sub>3</sub> | 0 |
A-6496 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Cl,6-CF<sub>3</sub> | 0 |
A-6497 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Cl,6-OMe | 0 |
A-6498 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 3-Cl,6-OMe | 0 |
A-6499 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 4-Cl,2-OMe | 0 |
A-6500 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2,4-Me<sub>2</sub> | 0 |
A-6501 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2,5-Me<sub>2</sub> | 0 |
A-6502 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2,6-Me<sub>2</sub> | 0 |
A-6503 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-6504 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-6505 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-6506 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Me,4-OMe | 0 |
A-6507 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Me,5-OMe | 0 |
A-6508 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Me,6-OMe | 0 |
A-6509 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 3-Me,6-OMe | 0 |
A-6510 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 4-Me,2-OMe | 0 |
A-6511 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2,5-OMe<sub>2</sub> | 0 |
A-6512 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2,6-OMe<sub>2</sub> | 0 |
A-6513 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-6514 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-6515 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-6516 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-6517 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-6518 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,5-F | 0 |
A-6519 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-F | 0 |
A-6520 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,5-Me | 0 |
A-6521 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-Me | 0 |
A-6522 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-乙烯基,6-F | 0 |
A-6523 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-乙烯基,6-Me | 0 |
A-6524 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,5-F | 0 |
A-6525 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,6-F | 0 |
A-6526 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,5-Cl | 0 |
A-6527 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,6-Cl | 0 |
A-6528 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,5-Me | 0 |
A-6529 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OEt,6-Me | 0 |
A-6530 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-6531 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-6532 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-6533 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-6534 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-6535 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-6536 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-6537 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-6538 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-6539 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-6540 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-6541 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-6542 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-6543 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-6544 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-6545 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-6546 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-6547 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-6548 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-6549 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-6550 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
[表116]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6551 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-6552 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-6553 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-6554 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-6555 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-6556 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-6557 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-6558 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-6559 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-6560 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-6561 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-6562 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-6563 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-6564 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-6565 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-6566 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-6567 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-6568 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-6569 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-6570 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-6571 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-6572 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-6573 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-6574 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-6575 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-6576 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-6577 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-6578 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-6579 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-6580 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-6581 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-6582 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-6583 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-6584 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-6585 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-6586 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-6587 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-6588 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-6589 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-6590 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-6591 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-6592 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-6593 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-6594 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-6595 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-6596 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-6597 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-6598 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-6599 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-6600 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-6601 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-6602 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-6603 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-6604 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-6605 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-6606 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-6607 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
[表117]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6608 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-6609 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-6610 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-6611 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-6612 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-6613 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-6614 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-6615 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-6616 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-6617 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-6618 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-6619 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-6620 | H | H | H | H | H | O | S(=O)<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-6621 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | H | 0 |
A-6622 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-F | 0 |
A-6623 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Cl | 0 |
A-6624 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Br | 0 |
A-6625 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OH | 0 |
A-6626 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me | 0 |
A-6627 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Et | 0 |
A-6628 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Pr | 0 |
A-6629 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CF<sub>3</sub> | 0 |
A-6630 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-6631 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-6632 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-6633 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基 | 0 |
A-6634 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丁基 | 0 |
A-6635 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环戊基 | 0 |
A-6636 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-乙烯基 | 0 |
A-6637 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-烯丙基 | 0 |
A-6638 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-6639 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(三氟乙烯基) | 0 |
A-6640 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OMe | 0 |
A-6641 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt | 0 |
A-6642 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OPr | 0 |
A-6643 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-O(i-Pr) | 0 |
A-6644 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCF<sub>3</sub> | 0 |
A-6645 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub> | 0 |
A-6646 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基) | 0 |
A-6647 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丁基氧基) | 0 |
A-6648 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环戊基氧基) | 0 |
A-6649 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-6650 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环氧乙烷-2-基) | 0 |
A-6651 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe | 0 |
A-6652 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-SMe | 0 |
A-6653 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me | 0 |
A-6654 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-S(=O)Me | 0 |
A-6655 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-6656 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-6657 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub> | 0 |
A-6658 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-SCF<sub>3</sub> | 0 |
A-6659 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-S(=O)CF<sub>3</sub> | 0 |
A-6660 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
A-6661 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基) | 0 |
A-6662 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基亚磺酰基) | 0 |
A-6663 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基磺酰基) | 0 |
A-6664 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me | 0 |
[表118]
[表119]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6722 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,5-Me | 0 |
A-6723 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,6-Me | 0 |
A-6724 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-乙烯基,6-F | 0 |
A-6725 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-乙烯基,6-Me | 0 |
A-6726 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-F | 0 |
A-6727 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-F | 0 |
A-6728 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-Cl | 0 |
A-6729 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-Cl | 0 |
A-6730 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-Me | 0 |
A-6731 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-Me | 0 |
A-6732 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-6733 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-6734 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-6735 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-6736 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-6737 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-6738 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-6739 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-6740 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,5-F | 0 |
A-6741 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,6-F | 0 |
A-6742 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,5-Me | 0 |
A-6743 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,6-Me | 0 |
A-6744 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,5-F | 0 |
A-6745 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,6-F | 0 |
A-6746 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-6747 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-6748 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-6749 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-6750 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-6751 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-6752 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-6753 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-6754 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-6755 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-6756 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-6757 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-6758 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-6759 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-6760 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-6761 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-6762 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-6763 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-6764 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-6765 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-6766 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-6767 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-6768 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,5-F | 0 |
A-6769 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,6-F | 0 |
A-6770 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-6771 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-6772 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-6773 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-6774 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-6775 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-6776 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-6777 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-6778 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
[表120]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6779 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-6780 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-6781 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-6782 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-6783 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-6784 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-6785 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-6786 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-6787 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-6788 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-6789 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-6790 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-6791 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-6792 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-6793 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-6794 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-6795 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-6796 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-6797 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-6798 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,4-F | 0 |
A-6799 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,5-F | 0 |
A-6800 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-F | 0 |
A-6801 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-Me | 0 |
A-6802 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,5-OMe | 0 |
A-6803 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-OMe | 0 |
A-6804 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-CN,6-Me | 0 |
A-6805 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-CN,6-OMe | 0 |
A-6806 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 4-CN,2-Me | 0 |
A-6807 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 4-CN,2-OMe | 0 |
A-6808 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-6809 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-6810 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-6811 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-6812 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-6813 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-6814 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-6815 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,6-Et | 0 |
A-6816 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,6-OMe | 0 |
A-6817 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,5-Et | 0 |
A-6818 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-6819 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Et,6-F | 0 |
A-6820 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-6821 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-6822 | H | H | H | H | H | O | S(=O)<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-6823 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | H | 0 |
A-6824 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-F | 0 |
A-6825 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Cl | 0 |
A-6826 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Br | 0 |
A-6827 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OH | 0 |
A-6828 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me | 0 |
A-6829 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Et | 0 |
A-6830 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Pr | 0 |
A-6831 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CF<sub>3</sub> | 0 |
A-6832 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-6833 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-6834 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-6835 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基 | 0 |
[表121]
[表122]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6893 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-F,6-OMe | 0 |
A-6894 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-F,6-OMe | 0 |
A-6895 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2,6-Cl<sub>2</sub> | 0 |
A-6896 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Cl,6-Me | 0 |
A-6897 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-Cl,6-Me | 0 |
A-6898 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 4-Cl,2-Me | 0 |
A-6899 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Cl,5-CF<sub>3</sub> | 0 |
A-6900 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Cl,6-CF<sub>3</sub> | 0 |
A-6901 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Cl,6-OMe | 0 |
A-6902 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-Cl,6-OMe | 0 |
A-6903 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 4-Cl,2-OMe | 0 |
A-6904 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2,4-Me<sub>2</sub> | 0 |
A-6905 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2,5-Me<sub>2</sub> | 0 |
A-6906 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2,6-Me<sub>2</sub> | 0 |
A-6907 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-6908 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-6909 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-6910 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,4-OMe | 0 |
A-6911 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,5-OMe | 0 |
A-6912 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,6-OMe | 0 |
A-6913 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-Me,6-OMe | 0 |
A-6914 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 4-Me,2-OMe | 0 |
A-6915 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2,5-OMe<sub>2</sub> | 0 |
A-6916 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2,6-OMe<sub>2</sub> | 0 |
A-6917 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-6918 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-6919 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-6920 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-6921 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-6922 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,5-F | 0 |
A-6923 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,6-F | 0 |
A-6924 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,5-Me | 0 |
A-6925 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,6-Me | 0 |
A-6926 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-乙烯基,6-F | 0 |
A-6927 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-乙烯基,6-Me | 0 |
A-6928 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-F | 0 |
A-6929 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-F | 0 |
A-6930 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-Cl | 0 |
A-6931 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-Cl | 0 |
A-6932 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,5-Me | 0 |
A-6933 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OEt,6-Me | 0 |
A-6934 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-6935 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-6936 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-6937 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-6938 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-6939 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-6940 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-6941 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-6942 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,5-F | 0 |
A-6943 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,6-F | 0 |
A-6944 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,5-Me | 0 |
A-6945 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SMe,6-Me | 0 |
A-6946 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,5-F | 0 |
A-6947 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,6-F | 0 |
A-6948 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-6949 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)Me,6-Me | 0 |
[表123]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-6950 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-6951 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-6952 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-6953 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-6954 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-6955 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-6956 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-6957 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-6958 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-6959 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-6960 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-6961 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-6962 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-6963 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-6964 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-6965 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-6966 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-6967 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-6968 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-6969 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-6970 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,5-F | 0 |
A-6971 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,6-F | 0 |
A-6972 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-6973 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-6974 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-6975 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-6976 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-6977 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-6978 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-6979 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-6980 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-6981 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-6982 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-6983 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-6984 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-6985 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-6986 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-6987 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-6988 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-6989 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-6990 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-6991 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-6992 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-6993 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-6994 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-6995 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-6996 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-6997 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-6998 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-6999 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-7000 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,4-F | 0 |
A-7001 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,5-F | 0 |
A-7002 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-F | 0 |
A-7003 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-Me | 0 |
A-7004 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,5-OMe | 0 |
A-7005 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CN,6-OMe | 0 |
A-7006 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-CN,6-Me | 0 |
[表124]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-7007 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 3-CN,6-OMe | 0 |
A-7008 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 4-CN,2-Me | 0 |
A-7009 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 4-CN,2-OMe | 0 |
A-7010 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-7011 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-7012 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-7013 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-7014 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-7015 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-7016 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-7017 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,6-Et | 0 |
A-7018 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-环丙基,6-OMe | 0 |
A-7019 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Me,5-Et | 0 |
A-7020 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-7021 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-Et,6-F | 0 |
A-7022 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-7023 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-7024 | H | H | H | H | H | O | CH<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-7025 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | H | 0 |
A-7026 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-F | 0 |
A-7027 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-Cl | 0 |
A-7028 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-Br | 0 |
A-7029 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OH | 0 |
A-7030 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-Me | 0 |
A-7031 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-Et | 0 |
A-7032 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-Pr | 0 |
A-7033 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CF<sub>3</sub> | 0 |
A-7034 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub> | 0 |
A-7035 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>F | 0 |
A-7036 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CF<sub>2</sub>Cl | 0 |
A-7037 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-环丙基 | 0 |
A-7038 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-环丁基 | 0 |
A-7039 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-环戊基 | 0 |
A-7040 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-乙烯基 | 0 |
A-7041 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-烯丙基 | 0 |
A-7042 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(丙-1-烯-1-基) | 0 |
A-7043 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(三氟乙烯基) | 0 |
A-7044 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OMe | 0 |
A-7045 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OEt | 0 |
A-7046 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OPr | 0 |
A-7047 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-O(i-Pr) | 0 |
A-7048 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OCF<sub>3</sub> | 0 |
A-7049 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub> | 0 |
A-7050 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环丙基氧基) | 0 |
A-7051 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环丁基氧基) | 0 |
A-7052 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环戊基氧基) | 0 |
A-7053 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-7054 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环氧乙烷-2-基) | 0 |
A-7055 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-SMe | 0 |
A-7056 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 3-SMe | 0 |
A-7057 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)Me | 0 |
A-7058 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 3-S(=O)Me | 0 |
A-7059 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me | 0 |
A-7060 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 3-S(=O)<sub>2</sub>Me | 0 |
A-7061 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub> | 0 |
A-7062 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 3-SCF<sub>3</sub> | 0 |
A-7063 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 3-S(=O)CF<sub>3</sub> | 0 |
[表125]
[表126]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-7121 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-7122 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-7123 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-7124 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-环丙基,5-F | 0 |
A-7125 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-环丙基,6-F | 0 |
A-7126 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-环丙基,5-Me | 0 |
A-7127 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-环丙基,6-Me | 0 |
A-7128 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-乙烯基,6-F | 0 |
A-7129 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-乙烯基,6-Me | 0 |
A-7130 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OEt,5-F | 0 |
A-7131 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OEt,6-F | 0 |
A-7132 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OEt,5-Cl | 0 |
A-7133 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OEt,6-Cl | 0 |
A-7134 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OEt,5-Me | 0 |
A-7135 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OEt,6-Me | 0 |
A-7136 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-7137 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-7138 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-7139 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-7140 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-7141 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-7142 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-7143 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-7144 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-7145 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-7146 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-7147 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-7148 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-7149 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-7150 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-7151 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-7152 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-7153 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-7154 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-7155 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-7156 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-7157 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-7158 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-7159 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-7160 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-7161 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-7162 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-7163 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-7164 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-7165 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-7166 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-7167 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-7168 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-7169 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-7170 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-7171 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-7172 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-7173 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-7174 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-7175 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-7176 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-7177 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
[表127]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-7178 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-7179 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-7180 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-7181 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-7182 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-7183 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-7184 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-7185 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-7186 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-7187 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-7188 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-7189 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-7190 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-7191 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-7192 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-7193 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-7194 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-7195 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-7196 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-7197 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-7198 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-7199 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-7200 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-7201 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-7202 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CN,4-F | 0 |
A-7203 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CN,5-F | 0 |
A-7204 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CN,6-F | 0 |
A-7205 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CN,6-Me | 0 |
A-7206 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CN,5-OMe | 0 |
A-7207 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CN,6-OMe | 0 |
A-7208 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 3-CN,6-Me | 0 |
A-7209 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 3-CN,6-OMe | 0 |
A-7210 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 4-CN,2-Me | 0 |
A-7211 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 4-CN,2-OMe | 0 |
A-7212 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-7213 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-7214 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-7215 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-7216 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-7217 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-7218 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-7219 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-Me,6-Et | 0 |
A-7220 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-环丙基,6-OMe | 0 |
A-7221 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-Me,5-Et | 0 |
A-7222 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-7223 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-Et,6-F | 0 |
A-7224 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-7225 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-7226 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)OCH<sub>3</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-7227 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | H | 0 |
A-7228 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-F | 0 |
A-7229 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Cl | 0 |
A-7230 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Br | 0 |
A-7231 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OH | 0 |
A-7232 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Me | 0 |
A-7233 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Et | 0 |
A-7234 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Pr | 0 |
[表128]
[表129]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-7292 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NO<sub>2</sub> | 0 |
A-7293 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-F,6-Cl | 0 |
A-7294 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-F,6-Me | 0 |
A-7295 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 3-F,6-Me | 0 |
A-7296 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 4-F,2-Me | 0 |
A-7297 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-F,6-OMe | 0 |
A-7298 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 3-F,6-OMe | 0 |
A-7299 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2,6-Cl<sub>2</sub> | 0 |
A-7300 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Cl,6-Me | 0 |
A-7301 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 3-Cl,6-Me | 0 |
A-7302 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 4-Cl,2-Me | 0 |
A-7303 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Cl,5-CF<sub>3</sub> | 0 |
A-7304 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Cl,6-CF<sub>3</sub> | 0 |
A-7305 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Cl,6-OMe | 0 |
A-7306 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 3-Cl,6-OMe | 0 |
A-7307 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 4-Cl,2-OMe | 0 |
A-7308 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2,4-Me<sub>2</sub> | 0 |
A-7309 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2,5-Me<sub>2</sub> | 0 |
A-7310 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2,6-Me<sub>2</sub> | 0 |
A-7311 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-7312 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-7313 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-7314 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Me,4-OMe | 0 |
A-7315 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Me,5-OMe | 0 |
A-7316 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Me,6-OMe | 0 |
A-7317 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 3-Me,6-OMe | 0 |
A-7318 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 4-Me,2-OMe | 0 |
A-7319 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2,5-OMe<sub>2</sub> | 0 |
A-7320 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2,6-OMe<sub>2</sub> | 0 |
A-7321 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-7322 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-7323 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-7324 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-7325 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-7326 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-环丙基,5-F | 0 |
A-7327 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-环丙基,6-F | 0 |
A-7328 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-环丙基,5-Me | 0 |
A-7329 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-环丙基,6-Me | 0 |
A-7330 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-乙烯基,6-F | 0 |
A-7331 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-乙烯基,6-Me | 0 |
A-7332 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OEt,5-F | 0 |
A-7333 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OEt,6-F | 0 |
A-7334 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OEt,5-Cl | 0 |
A-7335 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OEt,6-Cl | 0 |
A-7336 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OEt,5-Me | 0 |
A-7337 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OEt,6-Me | 0 |
A-7338 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-7339 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-7340 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-7341 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-7342 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-(环丙基氧基),5-F | 0 |
A-7343 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-(环丙基氧基),6-F | 0 |
A-7344 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-7345 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-7346 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-SMe,5-F | 0 |
A-7347 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-SMe,6-F | 0 |
A-7348 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-SMe,5-Me | 0 |
[表130]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-7349 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-SMe,6-Me | 0 |
A-7350 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)Me,5-F | 0 |
A-7351 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)Me,6-F | 0 |
A-7352 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-7353 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-7354 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-7355 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-7356 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-7357 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-7358 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-7359 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-7360 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-7361 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-7362 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-7363 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-7364 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-7365 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-7366 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-7367 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-7368 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-7369 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-7370 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-7371 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-7372 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-7373 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-7374 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-C(=O)Me,5-F | 0 |
A-7375 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-C(=O)Me,6-F | 0 |
A-7376 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-7377 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-7378 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-7379 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-7380 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-7381 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-7382 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-7383 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-7384 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-7385 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-7386 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-7387 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-7388 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-7389 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-7390 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-7391 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-7392 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-7393 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-7394 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-7395 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-7396 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-7397 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-7398 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-7399 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-7400 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-7401 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-7402 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-7403 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-7404 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CN,4-F | 0 |
A-7405 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CN,5-F | 0 |
[表131]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-7406 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CN,6-F | 0 |
A-7407 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CN,6-Me | 0 |
A-7408 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CN,5-OMe | 0 |
A-7409 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CN,6-OMe | 0 |
A-7410 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 3-CN,6-Me | 0 |
A-7411 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 3-CN,6-OMe | 0 |
A-7412 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 4-CN,2-Me | 0 |
A-7413 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 4-CN,2-OMe | 0 |
A-7414 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NO<sub>2</sub>,4-F | 0 |
A-7415 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NO<sub>2</sub>,5-F | 0 |
A-7416 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NO<sub>2</sub>,6-F | 0 |
A-7417 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-7418 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-7419 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-7420 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-7421 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Me,6-Et | 0 |
A-7422 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-环丙基,6-OMe | 0 |
A-7423 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Me,5-Et | 0 |
A-7424 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2,6-Et<sub>2</sub> | 0 |
A-7425 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-Et,6-F | 0 |
A-7426 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-7427 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-7428 | H | H | H | H | H | O | CH<sub>2</sub>C(=O)NH<sub>2</sub> | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-7429 | H | H | H | H | H | O | CH=NOH | H | H | 0 |
A-7430 | H | H | H | H | H | O | CH=NOH | H | 2-F | 0 |
A-7431 | H | H | H | H | H | O | CH=NOH | H | 2-Cl | 0 |
A-7432 | H | H | H | H | H | O | CH=NOH | H | 2-Br | 0 |
A-7433 | H | H | H | H | H | O | CH=NOH | H | 2-OH | 0 |
A-7434 | H | H | H | H | H | O | CH=NOH | H | 2-Me | 0 |
A-7435 | H | H | H | H | H | O | CH=NOH | H | 2-Et | 0 |
A-7436 | H | H | H | H | H | O | CH=NOH | H | 2-Pr | 0 |
A-7437 | H | H | H | H | H | O | CH=NOH | H | 2-CF<sub>3</sub> | 0 |
A-7438 | H | H | H | H | H | O | CH=NOH | H | 2-CHF<sub>2</sub> | 0 |
A-7439 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>F | 0 |
A-7440 | H | H | H | H | H | O | CH=NOH | H | 2-CF<sub>2</sub>Cl | 0 |
A-7441 | H | H | H | H | H | O | CH=NOH | H | 2-环丙基 | 0 |
A-7442 | H | H | H | H | H | O | CH=NOH | H | 2-环丁基 | 0 |
A-7443 | H | H | H | H | H | O | CH=NOH | H | 2-环戊基 | 0 |
A-7444 | H | H | H | H | H | O | CH=NOH | H | 2-乙烯基 | 0 |
A-7445 | H | H | H | H | H | O | CH=NOH | H | 2-烯丙基 | 0 |
A-7446 | H | H | H | H | H | O | CH=NOH | H | 2-(丙-1-烯-1-基) | 0 |
A-7447 | H | H | H | H | H | O | CH=NOH | H | 2-(三氟乙烯基) | 0 |
A-7448 | H | H | H | H | H | O | CH=NOH | H | 2-OMe | 0 |
A-7449 | H | H | H | H | H | O | CH=NOH | H | 2-OEt | 0 |
A-7450 | H | H | H | H | H | O | CH=NOH | H | 2-OPr | 0 |
A-7451 | H | H | H | H | H | O | CH=NOH | H | 2-O(i-Pr) | 0 |
A-7452 | H | H | H | H | H | O | CH=NOH | H | 2-OCF<sub>3</sub> | 0 |
A-7453 | H | H | H | H | H | O | CH=NOH | H | 2-OCHF<sub>2</sub> | 0 |
A-7454 | H | H | H | H | H | O | CH=NOH | H | 2-(环丙基氧基) | 0 |
A-7455 | H | H | H | H | H | O | CH=NOH | H | 2-(环丁基氧基) | 0 |
A-7456 | H | H | H | H | H | O | CH=NOH | H | 2-(环戊基氧基) | 0 |
A-7457 | H | H | H | H | H | O | CH=NOH | H | 2-((2,2-二氯环丙基)氧基) | 0 |
A-7458 | H | H | H | H | H | O | CH=NOH | H | 2-(环氧乙烷-2-基) | 0 |
A-7459 | H | H | H | H | H | O | CH=NOH | H | 2-SMe | 0 |
A-7460 | H | H | H | H | H | O | CH=NOH | H | 3-SMe | 0 |
A-7461 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)Me | 0 |
A-7462 | H | H | H | H | H | O | CH=NOH | H | 3-S(=O)Me | 0 |
[表132]
[表133]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-7520 | H | H | H | H | H | O | CH=NOH | H | 4-Me,2-OMe | 0 |
A-7521 | H | H | H | H | H | O | CH=NOH | H | 2,5-OMe<sub>2</sub> | 0 |
A-7522 | H | H | H | H | H | O | CH=NOH | H | 2,6-OMe<sub>2</sub> | 0 |
A-7523 | H | H | H | H | H | O | CH=NOH | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-7524 | H | H | H | H | H | O | CH=NOH | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-7525 | H | H | H | H | H | O | CH=NOH | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-7526 | H | H | H | H | H | O | CH=NOH | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-7527 | H | H | H | H | H | O | CH=NOH | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-7528 | H | H | H | H | H | O | CH=NOH | H | 2-环丙基,5-F | 0 |
A-7529 | H | H | H | H | H | O | CH=NOH | H | 2-环丙基,6-F | 0 |
A-7530 | H | H | H | H | H | O | CH=NOH | H | 2-环丙基,5-Me | 0 |
A-7531 | H | H | H | H | H | O | CH=NOH | H | 2-环丙基,6-Me | 0 |
A-7532 | H | H | H | H | H | O | CH=NOH | H | 2-乙烯基,6-F | 0 |
A-7533 | H | H | H | H | H | O | CH=NOH | H | 2-乙烯基,6-Me | 0 |
A-7534 | H | H | H | H | H | O | CH=NOH | H | 2-OEt,5-F | 0 |
A-7535 | H | H | H | H | H | O | CH=NOH | H | 2-OEt,6-F | 0 |
A-7536 | H | H | H | H | H | O | CH=NOH | H | 2-OEt,5-Cl | 0 |
A-7537 | H | H | H | H | H | O | CH=NOH | H | 2-OEt,6-Cl | 0 |
A-7538 | H | H | H | H | H | O | CH=NOH | H | 2-OEt,5-Me | 0 |
A-7539 | H | H | H | H | H | O | CH=NOH | H | 2-OEt,6-Me | 0 |
A-7540 | H | H | H | H | H | O | CH=NOH | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-7541 | H | H | H | H | H | O | CH=NOH | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-7542 | H | H | H | H | H | O | CH=NOH | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-7543 | H | H | H | H | H | O | CH=NOH | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-7544 | H | H | H | H | H | O | CH=NOH | H | 2-(环丙基氧基),5-F | 0 |
A-7545 | H | H | H | H | H | O | CH=NOH | H | 2-(环丙基氧基),6-F | 0 |
A-7546 | H | H | H | H | H | O | CH=NOH | H | 2-(环丙基氧基),5-Me | 0 |
A-7547 | H | H | H | H | H | O | CH=NOH | H | 2-(环丙基氧基),6-Me | 0 |
A-7548 | H | H | H | H | H | O | CH=NOH | H | 2-SMe,5-F | 0 |
A-7549 | H | H | H | H | H | O | CH=NOH | H | 2-SMe,6-F | 0 |
A-7550 | H | H | H | H | H | O | CH=NOH | H | 2-SMe,5-Me | 0 |
A-7551 | H | H | H | H | H | O | CH=NOH | H | 2-SMe,6-Me | 0 |
A-7552 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)Me,5-F | 0 |
A-7553 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)Me,6-F | 0 |
A-7554 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)Me,5-Me | 0 |
A-7555 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)Me,6-Me | 0 |
A-7556 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-7557 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-7558 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-7559 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-7560 | H | H | H | H | H | O | CH=NOH | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-7561 | H | H | H | H | H | O | CH=NOH | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-7562 | H | H | H | H | H | O | CH=NOH | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-7563 | H | H | H | H | H | O | CH=NOH | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-7564 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-7565 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-7566 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-7567 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-7568 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-7569 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-7570 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-7571 | H | H | H | H | H | O | CH=NOH | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-7572 | H | H | H | H | H | O | CH=NOH | H | 2-(环丙基硫基),5-F | 0 |
A-7573 | H | H | H | H | H | O | CH=NOH | H | 2-(环丙基硫基),6-F | 0 |
A-7574 | H | H | H | H | H | O | CH=NOH | H | 2-(环丙基硫基),5-Me | 0 |
A-7575 | H | H | H | H | H | O | CH=NOH | H | 2-(环丙基硫基),6-Me | 0 |
A-7576 | H | H | H | H | H | O | CH=NOH | H | 2-C(=O)Me,5-F | 0 |
[表134]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-7577 | H | H | H | H | H | O | CH=NOH | H | 2-C(=O)Me,6-F | 0 |
A-7578 | H | H | H | H | H | O | CH=NOH | H | 2-C(=O)Me,5-Me | 0 |
A-7579 | H | H | H | H | H | O | CH=NOH | H | 2-C(=O)Me,6-Me | 0 |
A-7580 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-7581 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-7582 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-7583 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-7584 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-7585 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-7586 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-7587 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-7588 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-7589 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-7590 | H | H | H | H | H | O | CH=NOH | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-7591 | H | H | H | H | H | O | CH=NOH | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-7592 | H | H | H | H | H | O | CH=NOH | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-7593 | H | H | H | H | H | O | CH=NOH | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-7594 | H | H | H | H | H | O | CH=NOH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-7595 | H | H | H | H | H | O | CH=NOH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-7596 | H | H | H | H | H | O | CH=NOH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-7597 | H | H | H | H | H | O | CH=NOH | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-7598 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-7599 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-7600 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-7601 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-7602 | H | H | H | H | H | O | CH=NOH | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-7603 | H | H | H | H | H | O | CH=NOH | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-7604 | H | H | H | H | H | O | CH=NOH | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-7605 | H | H | H | H | H | O | CH=NOH | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-7606 | H | H | H | H | H | O | CH=NOH | H | 2-CN,4-F | 0 |
A-7607 | H | H | H | H | H | O | CH=NOH | H | 2-CN,5-F | 0 |
A-7608 | H | H | H | H | H | O | CH=NOH | H | 2-CN,6-F | 0 |
A-7609 | H | H | H | H | H | O | CH=NOH | H | 2-CN,6-Me | 0 |
A-7610 | H | H | H | H | H | O | CH=NOH | H | 2-CN,5-OMe | 0 |
A-7611 | H | H | H | H | H | O | CH=NOH | H | 2-CN,6-OMe | 0 |
A-7612 | H | H | H | H | H | O | CH=NOH | H | 3-CN,6-Me | 0 |
A-7613 | H | H | H | H | H | O | CH=NOH | H | 3-CN,6-OMe | 0 |
A-7614 | H | H | H | H | H | O | CH=NOH | H | 4-CN,2-Me | 0 |
A-7615 | H | H | H | H | H | O | CH=NOH | H | 4-CN,2-OMe | 0 |
A-7616 | H | H | H | H | H | O | CH=NOH | H | 2-NO<sub>2</sub>,4-F | 0 |
A-7617 | H | H | H | H | H | O | CH=NOH | H | 2-NO<sub>2</sub>,5-F | 0 |
A-7618 | H | H | H | H | H | O | CH=NOH | H | 2-NO<sub>2</sub>,6-F | 0 |
A-7619 | H | H | H | H | H | O | CH=NOH | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-7620 | H | H | H | H | H | O | CH=NOH | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-7621 | H | H | H | H | H | O | CH=NOH | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-7622 | H | H | H | H | H | O | CH=NOH | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-7623 | H | H | H | H | H | O | CH=NOH | H | 2-Me,6-Et | 0 |
A-7624 | H | H | H | H | H | O | CH=NOH | H | 2-环丙基,6-OMe | 0 |
A-7625 | H | H | H | H | H | O | CH=NOH | H | 2-Me,5-Et | 0 |
A-7626 | H | H | H | H | H | O | CH=NOH | H | 2,6-Et<sub>2</sub> | 0 |
A-7627 | H | H | H | H | H | O | CH=NOH | H | 2-Et,6-F | 0 |
A-7628 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-7629 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-7630 | H | H | H | H | H | O | CH=NOH | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-7631 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | H | 0 |
A-7632 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-F | 0 |
A-7633 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-Cl | 0 |
[表135]
[表136]
[表137]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-7748 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),5-Me | 0 |
A-7749 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基氧基),6-Me | 0 |
A-7750 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-F | 0 |
A-7751 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-F | 0 |
A-7752 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,5-Me | 0 |
A-7753 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-SMe,6-Me | 0 |
A-7754 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-F | 0 |
A-7755 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-F | 0 |
A-7756 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,5-Me | 0 |
A-7757 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)Me,6-Me | 0 |
A-7758 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-7759 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-7760 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-7761 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-7762 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-7763 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-F | 0 |
A-7764 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-7765 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-7766 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-7767 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-7768 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-7769 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-7770 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-7771 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-7772 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-7773 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-7774 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-F | 0 |
A-7775 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-F | 0 |
A-7776 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),5-Me | 0 |
A-7777 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-(环丙基硫基),6-Me | 0 |
A-7778 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-F | 0 |
A-7779 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-F | 0 |
A-7780 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,5-Me | 0 |
A-7781 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-C(=O)Me,6-Me | 0 |
A-7782 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-7783 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-7784 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-7785 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-7786 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-7787 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-7788 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-7789 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-7790 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-7791 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-7792 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-7793 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-7794 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-7795 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-7796 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-7797 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-7798 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-7799 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-7800 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-7801 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-7802 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-7803 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-7804 | H | H | H | H | H | O | CH=NOCH<sub>2</sub>CH<sub>3</sub> | H | 2-NMe<sub>2</sub>,5-F | 0 |
[表138]
[表139]
[表140]
[表141]
[表142]
[表143]
[表144]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-8147 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OCHF<sub>2</sub>,6-F | 0 |
A-8148 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-8149 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-8150 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-(环丙基氧基),5-F | 0 |
A-8151 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-(环丙基氧基),6-F | 0 |
A-8152 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-(环丙基氧基),5-Me | 0 |
A-8153 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-(环丙基氧基),6-Me | 0 |
A-8154 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-SMe,5-F | 0 |
A-8155 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-SMe,6-F | 0 |
A-8156 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-SMe,5-Me | 0 |
A-8157 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-SMe,6-Me | 0 |
A-8158 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)Me,5-F | 0 |
A-8159 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)Me,6-F | 0 |
A-8160 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)Me,5-Me | 0 |
A-8161 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)Me,6-Me | 0 |
A-8162 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-8163 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-8164 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-8165 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-8166 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-SCF<sub>3</sub>,5-F | 0 |
A-8167 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-SCF<sub>3</sub>,6-F | 0 |
A-8168 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-SCF<sub>3</sub>,5-Me | 0 |
A-8169 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-SCF<sub>3</sub>,6-Me | 0 |
A-8170 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-8171 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-8172 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-8173 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-8174 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-8175 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-8176 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-8177 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-8178 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-(环丙基硫基),5-F | 0 |
A-8179 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-(环丙基硫基),6-F | 0 |
A-8180 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-(环丙基硫基),5-Me | 0 |
A-8181 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-(环丙基硫基),6-Me | 0 |
A-8182 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-C(=O)Me,5-F | 0 |
A-8183 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-C(=O)Me,6-F | 0 |
A-8184 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-C(=O)Me,5-Me | 0 |
A-8185 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-C(=O)Me,6-Me | 0 |
A-8186 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OH,5-F | 0 |
A-8187 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OH,6-F | 0 |
A-8188 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-8189 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-8190 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-8191 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-8192 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-8193 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-8194 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-8195 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-8196 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-8197 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-8198 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-8199 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-8200 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-8201 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-8202 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-8203 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
[表145]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-8204 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-8205 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-8206 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-8207 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-8208 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-NMe<sub>2</sub>,5-F | 0 |
A-8209 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-NMe<sub>2</sub>,6-F | 0 |
A-8210 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-NMe<sub>2</sub>,5-Me | 0 |
A-8211 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-NMe<sub>2</sub>,6-Me | 0 |
A-8212 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CN,4-F | 0 |
A-8213 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CN,5-F | 0 |
A-8214 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CN,6-F | 0 |
A-8215 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CN,6-Me | 0 |
A-8216 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CN,5-OMe | 0 |
A-8217 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CN,6-OMe | 0 |
A-8218 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 3-CN,6-Me | 0 |
A-8219 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 3-CN,6-OMe | 0 |
A-8220 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 4-CN,2-Me | 0 |
A-8221 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 4-CN,2-OMe | 0 |
A-8222 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-NO<sub>2</sub>,4-F | 0 |
A-8223 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-NO<sub>2</sub>,5-F | 0 |
A-8224 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-NO<sub>2</sub>,6-F | 0 |
A-8225 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-NO<sub>2</sub>,4-Me | 0 |
A-8226 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-NO<sub>2</sub>,5-Me | 0 |
A-8227 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-NO<sub>2</sub>,6-Me | 0 |
A-8228 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-Me,4,5-F<sub>2</sub> | 0 |
A-8229 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-Me,6-Et | 0 |
A-8230 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-环丙基,6-OMe | 0 |
A-8231 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-Me,5-Et | 0 |
A-8232 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2,6-Et<sub>2</sub> | 0 |
A-8233 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-Et,6-F | 0 |
A-8234 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-8235 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-8236 | H | H | H | H | H | O | CH<sub>3</sub> | CH<sub>3</sub> | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-8237 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | H | 0 |
A-8238 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-F | 0 |
A-8239 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Cl | 0 |
A-8240 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Br | 0 |
A-8241 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OH | 0 |
A-8242 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Me | 0 |
A-8243 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Et | 0 |
A-8244 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Pr | 0 |
A-8245 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CF<sub>3</sub> | 0 |
A-8246 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CHF<sub>2</sub> | 0 |
A-8247 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>F | 0 |
A-8248 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CF<sub>2</sub>Cl | 0 |
A-8249 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-环丙基 | 0 |
A-8250 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-环丁基 | 0 |
A-8251 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-环戊基 | 0 |
A-8252 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-乙烯基 | 0 |
A-8253 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-烯丙基 | 0 |
A-8254 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-(丙-1-烯-1-基) | 0 |
A-8255 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-(三氟乙烯基) | 0 |
A-8256 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OMe | 0 |
A-8257 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OEt | 0 |
A-8258 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OPr | 0 |
A-8259 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-O(i-Pr) | 0 |
A-8260 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OCF<sub>3</sub> | 0 |
[表146]
[表147]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-8318 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2,4-Me<sub>2</sub> | 0 |
A-8319 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2,5-Me<sub>2</sub> | 0 |
A-8320 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2,6-Me<sub>2</sub> | 0 |
A-8321 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Me,4-CF<sub>3</sub> | 0 |
A-8322 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Me,5-CF<sub>3</sub> | 0 |
A-8323 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Me,6-CF<sub>3</sub> | 0 |
A-8324 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Me,4-OMe | 0 |
A-8325 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Me,5-OMe | 0 |
A-8326 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Me,6-OMe | 0 |
A-8327 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 3-Me,6-OMe | 0 |
A-8328 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 4-Me,2-OMe | 0 |
A-8329 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2,5-OMe<sub>2</sub> | 0 |
A-8330 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2,6-OMe<sub>2</sub> | 0 |
A-8331 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OMe,6-CF<sub>3</sub> | 0 |
A-8332 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CHF<sub>2</sub>,5-F | 0 |
A-8333 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CHF<sub>2</sub>,6-F | 0 |
A-8334 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CHF<sub>2</sub>,5-Me | 0 |
A-8335 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CHF<sub>2</sub>,6-Me | 0 |
A-8336 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-环丙基,5-F | 0 |
A-8337 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-环丙基,6-F | 0 |
A-8338 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-环丙基,5-Me | 0 |
A-8339 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-环丙基,6-Me | 0 |
A-8340 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-乙烯基,6-F | 0 |
A-8341 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-乙烯基,6-Me | 0 |
A-8342 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OEt,5-F | 0 |
A-8343 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OEt,6-F | 0 |
A-8344 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OEt,5-Cl | 0 |
A-8345 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OEt,6-Cl | 0 |
A-8346 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OEt,5-Me | 0 |
A-8347 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OEt,6-Me | 0 |
A-8348 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OCHF<sub>2</sub>,5-F | 0 |
A-8349 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OCHF<sub>2</sub>,6-F | 0 |
A-8350 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-8351 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-8352 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-(环丙基氧基),5-F | 0 |
A-8353 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-(环丙基氧基),6-F | 0 |
A-8354 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-(环丙基氧基),5-Me | 0 |
A-8355 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-(环丙基氧基),6-Me | 0 |
A-8356 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-SMe,5-F | 0 |
A-8357 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-SMe,6-F | 0 |
A-8358 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-SMe,5-Me | 0 |
A-8359 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-SMe,6-Me | 0 |
A-8360 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)Me,5-F | 0 |
A-8361 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)Me,6-F | 0 |
A-8362 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)Me,5-Me | 0 |
A-8363 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)Me,6-Me | 0 |
A-8364 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-8365 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-8366 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-8367 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-8368 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-SCF<sub>3</sub>,5-F | 0 |
A-8369 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-SCF<sub>3</sub>,6-F | 0 |
A-8370 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-SCF<sub>3</sub>,5-Me | 0 |
A-8371 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-SCF<sub>3</sub>,6-Me | 0 |
A-8372 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-8373 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-8374 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
[表148]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-8375 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-8376 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-8377 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-8378 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-8379 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-8380 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-(环丙基硫基),5-F | 0 |
A-8381 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-(环丙基硫基),6-F | 0 |
A-8382 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-(环丙基硫基),5-Me | 0 |
A-8383 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-(环丙基硫基),6-Me | 0 |
A-8384 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-C(=O)Me,5-F | 0 |
A-8385 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-C(=O)Me,6-F | 0 |
A-8386 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-C(=O)Me,5-Me | 0 |
A-8387 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-C(=O)Me,6-Me | 0 |
A-8388 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>OH,5-F | 0 |
A-8389 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>OH,6-F | 0 |
A-8390 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-8391 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-8392 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-8393 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-8394 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-8395 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-8396 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-8397 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-8398 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-8399 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-8400 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-8401 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-8402 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-8403 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-8404 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-8405 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-8406 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-8407 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-8408 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-8409 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-8410 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-NMe<sub>2</sub>,5-F | 0 |
A-8411 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-NMe<sub>2</sub>,6-F | 0 |
A-8412 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-NMe<sub>2</sub>,5-Me | 0 |
A-8413 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-NMe<sub>2</sub>,6-Me | 0 |
A-8414 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CN,4-F | 0 |
A-8415 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CN,5-F | 0 |
A-8416 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CN,6-F | 0 |
A-8417 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CN,6-Me | 0 |
A-8418 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CN,5-OMe | 0 |
A-8419 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-CN,6-OMe | 0 |
A-8420 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 3-CN,6-Me | 0 |
A-8421 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 3-CN,6-OMe | 0 |
A-8422 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 4-CN,2-Me | 0 |
A-8423 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 4-CN,2-OMe | 0 |
A-8424 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-NO<sub>2</sub>,4-F | 0 |
A-8425 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-NO<sub>2</sub>,5-F | 0 |
A-8426 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-NO<sub>2</sub>,6-F | 0 |
A-8427 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-NO<sub>2</sub>,4-Me | 0 |
A-8428 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-NO<sub>2</sub>,5-Me | 0 |
A-8429 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-NO<sub>2</sub>,6-Me | 0 |
A-8430 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Me,4,5-F<sub>2</sub> | 0 |
A-8431 | H | H | H | H | H | O | CH<sub>2</sub>CN | CH<sub>2</sub>CN | 2-Me,6-Et | 0 |
[表149]
[表150]
[表151]
[表152]
[表153]
[表154]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-8717 | H | H | H | H | H | S | H | H | 2-Cl,5-CF<sub>3</sub> | 0 |
A-8718 | H | H | H | H | H | S | H | H | 2-Cl,6-CF<sub>3</sub> | 0 |
A-8719 | H | H | H | H | H | S | H | H | 2-Cl,6-OMe | 0 |
A-8720 | H | H | H | H | H | S | H | H | 3-Cl,6-OMe | 0 |
A-8721 | H | H | H | H | H | S | H | H | 4-Cl,2-OMe | 0 |
A-8722 | H | H | H | H | H | S | H | H | 2,4-Me<sub>2</sub> | 0 |
A-8723 | H | H | H | H | H | S | H | H | 2,5-Me<sub>2</sub> | 0 |
A-8724 | H | H | H | H | H | S | H | H | 2,6-Me<sub>2</sub> | 0 |
A-8725 | H | H | H | H | H | S | H | H | 2-Me,4-CF<sub>3</sub> | 0 |
A-8726 | H | H | H | H | H | S | H | H | 2-Me,5-CF<sub>3</sub> | 0 |
A-8727 | H | H | H | H | H | S | H | H | 2-Me,6-CF<sub>3</sub> | 0 |
A-8728 | H | H | H | H | H | S | H | H | 2-Me,4-OMe | 0 |
A-8729 | H | H | H | H | H | S | H | H | 2-Me,5-OMe | 0 |
A-8730 | H | H | H | H | H | S | H | H | 2-Me,6-OMe | 0 |
A-8731 | H | H | H | H | H | S | H | H | 3-Me,6-OMe | 0 |
A-8732 | H | H | H | H | H | S | H | H | 4-Me,2-OMe | 0 |
A-8733 | H | H | H | H | H | S | H | H | 2,5-OMe<sub>2</sub> | 0 |
A-8734 | H | H | H | H | H | S | H | H | 2,6-OMe<sub>2</sub> | 0 |
A-8735 | H | H | H | H | H | S | H | H | 2-OMe,6-CF<sub>3</sub> | 0 |
A-8736 | H | H | H | H | H | S | H | H | 2-CHF<sub>2</sub>,5-F | 0 |
A-8737 | H | H | H | H | H | S | H | H | 2-CHF<sub>2</sub>,6-F | 0 |
A-8738 | H | H | H | H | H | S | H | H | 2-CHF<sub>2</sub>,5-Me | 0 |
A-8739 | H | H | H | H | H | S | H | H | 2-CHF<sub>2</sub>,6-Me | 0 |
A-8740 | H | H | H | H | H | S | H | H | 2-环丙基,5-F | 0 |
A-8741 | H | H | H | H | H | S | H | H | 2-环丙基,6-F | 0 |
A-8742 | H | H | H | H | H | S | H | H | 2-环丙基,5-Me | 0 |
A-8743 | H | H | H | H | H | S | H | H | 2-环丙基,6-Me | 0 |
A-8744 | H | H | H | H | H | S | H | H | 2-乙烯基,6-F | 0 |
A-8745 | H | H | H | H | H | S | H | H | 2-乙烯基,6-Me | 0 |
A-8746 | H | H | H | H | H | S | H | H | 2-OEt,5-F | 0 |
A-8747 | H | H | H | H | H | S | H | H | 2-OEt,6-F | 0 |
A-8748 | H | H | H | H | H | S | H | H | 2-OEt,5-Cl | 0 |
A-8749 | H | H | H | H | H | S | H | H | 2-OEt,6-Cl | 0 |
A-8750 | H | H | H | H | H | S | H | H | 2-OEt,5-Me | 0 |
A-8751 | H | H | H | H | H | S | H | H | 2-OEt,6-Me | 0 |
A-8752 | H | H | H | H | H | S | H | H | 2-OCHF<sub>2</sub>,5-F | 0 |
A-8753 | H | H | H | H | H | S | H | H | 2-OCHF<sub>2</sub>,6-F | 0 |
A-8754 | H | H | H | H | H | S | H | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
A-8755 | H | H | H | H | H | S | H | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
A-8756 | H | H | H | H | H | S | H | H | 2-(环丙基氧基),5-F | 0 |
A-8757 | H | H | H | H | H | S | H | H | 2-(环丙基氧基),6-F | 0 |
A-8758 | H | H | H | H | H | S | H | H | 2-(环丙基氧基),5-Me | 0 |
A-8759 | H | H | H | H | H | S | H | H | 2-(环丙基氧基),6-Me | 0 |
A-8760 | H | H | H | H | H | S | H | H | 2-SMe,5-F | 0 |
A-8761 | H | H | H | H | H | S | H | H | 2-SMe,6-F | 0 |
A-8762 | H | H | H | H | H | S | H | H | 2-SMe,5-Me | 0 |
A-8763 | H | H | H | H | H | S | H | H | 2-SMe,6-Me | 0 |
A-8764 | H | H | H | H | H | S | H | H | 2-S(=O)Me,5-F | 0 |
A-8765 | H | H | H | H | H | S | H | H | 2-S(=O)Me,6-F | 0 |
A-8766 | H | H | H | H | H | S | H | H | 2-S(=O)Me,5-Me | 0 |
A-8767 | H | H | H | H | H | S | H | H | 2-S(=O)Me,6-Me | 0 |
A-8768 | H | H | H | H | H | S | H | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
A-8769 | H | H | H | H | H | S | H | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
A-8770 | H | H | H | H | H | S | H | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
A-8771 | H | H | H | H | H | S | H | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
A-8772 | H | H | H | H | H | S | H | H | 2-SCF<sub>3</sub>,5-F | 0 |
A-8773 | H | H | H | H | H | S | H | H | 2-SCF<sub>3</sub>,6-F | 0 |
[表155]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-8774 | H | H | H | H | H | S | H | H | 2-SCF<sub>3</sub>,5-Me | 0 |
A-8775 | H | H | H | H | H | S | H | H | 2-SCF<sub>3</sub>,6-Me | 0 |
A-8776 | H | H | H | H | H | S | H | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
A-8777 | H | H | H | H | H | S | H | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
A-8778 | H | H | H | H | H | S | H | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
A-8779 | H | H | H | H | H | S | H | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
A-8780 | H | H | H | H | H | S | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
A-8781 | H | H | H | H | H | S | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
A-8782 | H | H | H | H | H | S | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
A-8783 | H | H | H | H | H | S | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
A-8784 | H | H | H | H | H | S | H | H | 2-(环丙基硫基),5-F | 0 |
A-8785 | H | H | H | H | H | S | H | H | 2-(环丙基硫基),6-F | 0 |
A-8786 | H | H | H | H | H | S | H | H | 2-(环丙基硫基),5-Me | 0 |
A-8787 | H | H | H | H | H | S | H | H | 2-(环丙基硫基),6-Me | 0 |
A-8788 | H | H | H | H | H | S | H | H | 2-C(=O)Me,5-F | 0 |
A-8789 | H | H | H | H | H | S | H | H | 2-C(=O)Me,6-F | 0 |
A-8790 | H | H | H | H | H | S | H | H | 2-C(=O)Me,5-Me | 0 |
A-8791 | H | H | H | H | H | S | H | H | 2-C(=O)Me,6-Me | 0 |
A-8792 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OH,5-F | 0 |
A-8793 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OH,6-F | 0 |
A-8794 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
A-8795 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
A-8796 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
A-8797 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
A-8798 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
A-8799 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
A-8800 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
A-8801 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
A-8802 | H | H | H | H | H | S | H | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
A-8803 | H | H | H | H | H | S | H | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
A-8804 | H | H | H | H | H | S | H | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
A-8805 | H | H | H | H | H | S | H | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
A-8806 | H | H | H | H | H | S | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
A-8807 | H | H | H | H | H | S | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
A-8808 | H | H | H | H | H | S | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
A-8809 | H | H | H | H | H | S | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
A-8810 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
A-8811 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
A-8812 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
A-8813 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
A-8814 | H | H | H | H | H | S | H | H | 2-NMe<sub>2</sub>,5-F | 0 |
A-8815 | H | H | H | H | H | S | H | H | 2-NMe<sub>2</sub>,6-F | 0 |
A-8816 | H | H | H | H | H | S | H | H | 2-NMe<sub>2</sub>,5-Me | 0 |
A-8817 | H | H | H | H | H | S | H | H | 2-NMe<sub>2</sub>,6-Me | 0 |
A-8818 | H | H | H | H | H | S | H | H | 2-CN,4-F | 0 |
A-8819 | H | H | H | H | H | S | H | H | 2-CN,5-F | 0 |
A-8820 | H | H | H | H | H | S | H | H | 2-CN,6-F | 0 |
A-8821 | H | H | H | H | H | S | H | H | 2-CN,6-Me | 0 |
A-8822 | H | H | H | H | H | S | H | H | 2-CN,5-OMe | 0 |
A-8823 | H | H | H | H | H | S | H | H | 2-CN,6-OMe | 0 |
A-8824 | H | H | H | H | H | S | H | H | 3-CN,6-Me | 0 |
A-8825 | H | H | H | H | H | S | H | H | 3-CN,6-OMe | 0 |
A-8826 | H | H | H | H | H | S | H | H | 4-CN,2-Me | 0 |
A-8827 | H | H | H | H | H | S | H | H | 4-CN,2-OMe | 0 |
A-8828 | H | H | H | H | H | S | H | H | 2-NO<sub>2</sub>,4-F | 0 |
A-8829 | H | H | H | H | H | S | H | H | 2-NO<sub>2</sub>,5-F | 0 |
A-8830 | H | H | H | H | H | S | H | H | 2-NO<sub>2</sub>,6-F | 0 |
[表156]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-8831 | H | H | H | H | H | S | H | H | 2-NO<sub>2</sub>,4-Me | 0 |
A-8832 | H | H | H | H | H | S | H | H | 2-NO<sub>2</sub>,5-Me | 0 |
A-8833 | H | H | H | H | H | S | H | H | 2-NO<sub>2</sub>,6-Me | 0 |
A-8834 | H | H | H | H | H | S | H | H | 2-Me,4,5-F<sub>2</sub> | 0 |
A-8835 | H | H | H | H | H | S | H | H | 2-Me,6-Et | 0 |
A-8836 | H | H | H | H | H | S | H | H | 2-环丙基,6-OMe | 0 |
A-8837 | H | H | H | H | H | S | H | H | 2-Me,5-Et | 0 |
A-8838 | H | H | H | H | H | S | H | H | 2,6-Et<sub>2</sub> | 0 |
A-8839 | H | H | H | H | H | S | H | H | 2-Et,6-F | 0 |
A-8840 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
A-8841 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
A-8842 | H | H | H | H | H | S | H | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
A-8843 | H | H | H | H | H | O | H | H | H | 1 |
A-8844 | H | H | H | H | H | O | H | H | 2-F | 1 |
A-8845 | H | H | H | H | H | O | H | H | 3-F | 1 |
A-8846 | H | H | H | H | H | O | H | H | 4-F | 1 |
A-8847 | H | H | H | H | H | O | H | H | 2-Cl | 1 |
A-8848 | H | H | H | H | H | O | H | H | 3-Cl | 1 |
A-8849 | H | H | H | H | H | O | H | H | 4-Cl | 1 |
A-8850 | H | H | H | H | H | O | H | H | 2-Br | 1 |
A-8851 | H | H | H | H | H | O | H | H | 3-Br | 1 |
A-8852 | H | H | H | H | H | O | H | H | 4-Br | 1 |
A-8853 | H | H | H | H | H | O | H | H | 2-I | 1 |
A-8854 | H | H | H | H | H | O | H | H | 3-I | 1 |
A-8855 | H | H | H | H | H | O | H | H | 4-I | 1 |
A-8856 | H | H | H | H | H | O | H | H | 2-OH | 1 |
A-8857 | H | H | H | H | H | O | H | H | 3-OH | 1 |
A-8858 | H | H | H | H | H | O | H | H | 4-OH | 1 |
A-8859 | H | H | H | H | H | O | H | H | 2-SH | 1 |
A-8860 | H | H | H | H | H | O | H | H | 3-SH | 1 |
A-8861 | H | H | H | H | H | O | H | H | 4-SH | 1 |
A-8862 | H | H | H | H | H | O | H | H | 2-Me | 1 |
A-8863 | H | H | H | H | H | O | H | H | 3-Me | 1 |
A-8864 | H | H | H | H | H | O | H | H | 4-Me | 1 |
A-8865 | H | H | H | H | H | O | H | H | 2-Et | 1 |
A-8866 | H | H | H | H | H | O | H | H | 3-Et | 1 |
A-8867 | H | H | H | H | H | O | H | H | 4-Et | 1 |
A-8868 | H | H | H | H | H | O | H | H | 2-Pr | 1 |
A-8869 | H | H | H | H | H | O | H | H | 3-Pr | 1 |
A-8870 | H | H | H | H | H | O | H | H | 4-Pr | 1 |
A-8871 | H | H | H | H | H | O | H | H | 2-i-Pr | 1 |
A-8872 | H | H | H | H | H | O | H | H | 3-i-Pr | 1 |
A-8873 | H | H | H | H | H | O | H | H | 4-i-Pr | 1 |
A-8874 | H | H | H | H | H | O | H | H | 2-Bu | 1 |
A-8875 | H | H | H | H | H | O | H | H | 3-Bu | 1 |
A-8876 | H | H | H | H | H | O | H | H | 4-Bu | 1 |
A-8877 | H | H | H | H | H | O | H | H | 2-s-Bu | 1 |
A-8878 | H | H | H | H | H | O | H | H | 3-s-Bu | 1 |
A-8879 | H | H | H | H | H | O | H | H | 4-s-Bu | 1 |
A-8880 | H | H | H | H | H | O | H | H | 2-i-Bu | 1 |
A-8881 | H | H | H | H | H | O | H | H | 3-i-Bu | 1 |
A-8882 | H | H | H | H | H | O | H | H | 4-i-Bu | 1 |
A-8883 | H | H | H | H | H | O | H | H | 2-t-Bu | 1 |
A-8884 | H | H | H | H | H | O | H | H | 3-t-Bu | 1 |
A-8885 | H | H | H | H | H | O | H | H | 4-t-Bu | 1 |
A-8886 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub> | 1 |
A-8887 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub> | 1 |
[表157]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-8888 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub> | 1 |
A-8889 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub> | 1 |
A-8890 | H | H | H | H | H | O | H | H | 3-CHF<sub>2</sub> | 1 |
A-8891 | H | H | H | H | H | O | H | H | 4-CHF<sub>2</sub> | 1 |
A-8892 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>F | 1 |
A-8893 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>F | 1 |
A-8894 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>F | 1 |
A-8895 | H | H | H | H | H | O | H | H | 2-CF<sub>2</sub>Cl | 1 |
A-8896 | H | H | H | H | H | O | H | H | 3-CF<sub>2</sub>Cl | 1 |
A-8897 | H | H | H | H | H | O | H | H | 4-CF<sub>2</sub>Cl | 1 |
A-8898 | H | H | H | H | H | O | H | H | 2-CF(CF<sub>3</sub>)<sub>2</sub> | 1 |
A-8899 | H | H | H | H | H | O | H | H | 3-CF(CF<sub>3</sub>)<sub>2</sub> | 1 |
A-8900 | H | H | H | H | H | O | H | H | 4-CF(CF<sub>3</sub>)<sub>2</sub> | 1 |
A-8901 | H | H | H | H | H | O | H | H | 2-环丙基 | 1 |
A-8902 | H | H | H | H | H | O | H | H | 3-环丙基 | 1 |
A-8903 | H | H | H | H | H | O | H | H | 4-环丙基 | 1 |
A-8904 | H | H | H | H | H | O | H | H | 2-环丁基 | 1 |
A-8905 | H | H | H | H | H | O | H | H | 3-环丁基 | 1 |
A-8906 | H | H | H | H | H | O | H | H | 4-环丁基 | 1 |
A-8907 | H | H | H | H | H | O | H | H | 2-环戊基 | 1 |
A-8908 | H | H | H | H | H | O | H | H | 3-环戊基 | 1 |
A-8909 | H | H | H | H | H | O | H | H | 4-环戊基 | 1 |
A-8910 | H | H | H | H | H | O | H | H | 2-(环丙基甲基) | 1 |
A-8911 | H | H | H | H | H | O | H | H | 3-(环丙基甲基) | 1 |
A-8912 | H | H | H | H | H | O | H | H | 4-(环丙基甲基) | 1 |
A-8913 | H | H | H | H | H | O | H | H | 2-(环丁基甲基) | 1 |
A-8914 | H | H | H | H | H | O | H | H | 3-(环丁基甲基) | 1 |
A-8915 | H | H | H | H | H | O | H | H | 4-(环丁基甲基) | 1 |
A-8916 | H | H | H | H | H | O | H | H | 2-(环戊基甲基) | 1 |
A-8917 | H | H | H | H | H | O | H | H | 3-(环戊基甲基) | 1 |
A-8918 | H | H | H | H | H | O | H | H | 4-(环戊基甲基) | 1 |
A-8919 | H | H | H | H | H | O | H | H | 2-(环丙基乙基) | 1 |
A-8920 | H | H | H | H | H | O | H | H | 3-(环丙基乙基) | 1 |
A-8921 | H | H | H | H | H | O | H | H | 4-(环丙基乙基) | 1 |
A-8922 | H | H | H | H | H | O | H | H | 2-(2,2-二氟环丙基) | 1 |
A-8923 | H | H | H | H | H | O | H | H | 3-(2,2-二氟环丙基) | 1 |
A-8924 | H | H | H | H | H | O | H | H | 4-(2,2-二氟环丙基) | 1 |
A-8925 | H | H | H | H | H | O | H | H | 2-(2,2-二氯环丙基) | 1 |
A-8926 | H | H | H | H | H | O | H | H | 3-(2,2-二氯环丙基) | 1 |
A-8927 | H | H | H | H | H | O | H | H | 4-(2,2-二氯环丙基) | 1 |
A-8928 | H | H | H | H | H | O | H | H | 2-乙烯基 | 1 |
A-8929 | H | H | H | H | H | O | H | H | 3-乙烯基 | 1 |
A-8930 | H | H | H | H | H | O | H | H | 4-乙烯基 | 1 |
A-8931 | H | H | H | H | H | O | H | H | 2-烯丙基 | 1 |
A-8932 | H | H | H | H | H | O | H | H | 3-烯丙基 | 1 |
A-8933 | H | H | H | H | H | O | H | H | 4-烯丙基 | 1 |
A-8934 | H | H | H | H | H | O | H | H | 2-(丙-1-烯-1-基) | 1 |
A-8935 | H | H | H | H | H | O | H | H | 3-(丙-1-烯-1-基) | 1 |
A-8936 | H | H | H | H | H | O | H | H | 4-(丙-1-烯-1-基) | 1 |
A-8937 | H | H | H | H | H | O | H | H | 2-(三氟乙烯基) | 1 |
A-8938 | H | H | H | H | H | O | H | H | 3-(三氟乙烯基) | 1 |
A-8939 | H | H | H | H | H | O | H | H | 4-(三氟乙烯基) | 1 |
A-8940 | H | H | H | H | H | O | H | H | 2-(2,2-二氯乙烯基) | 1 |
A-8941 | H | H | H | H | H | O | H | H | 3-(2,2-二氯乙烯基) | 1 |
A-8942 | H | H | H | H | H | O | H | H | 4-(2,2-二氯乙烯基) | 1 |
A-8943 | H | H | H | H | H | O | H | H | 2-乙炔基 | 1 |
A-8944 | H | H | H | H | H | O | H | H | 3-乙炔基 | 1 |
[表158]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-8945 | H | H | H | H | H | O | H | H | 4-乙炔基 | 1 |
A-8946 | H | H | H | H | H | O | H | H | 2-(1-丙炔-1-基) | 1 |
A-8947 | H | H | H | H | H | O | H | H | 3-(1-丙炔-1-基) | 1 |
A-8948 | H | H | H | H | H | O | H | H | 4-(1-丙炔-1-基) | 1 |
A-8949 | H | H | H | H | H | O | H | H | 2-(2-丙炔-1-基) | 1 |
A-8950 | H | H | H | H | H | O | H | H | 3-(2-丙炔-1-基) | 1 |
A-8951 | H | H | H | H | H | O | H | H | 4-(2-丙炔-1-基) | 1 |
A-8952 | H | H | H | H | H | O | H | H | 2-(2-环丙基乙炔基) | 1 |
A-8953 | H | H | H | H | H | O | H | H | 3-(2-环丙基乙炔基) | 1 |
A-8954 | H | H | H | H | H | O | H | H | 4-(2-环丙基乙炔基) | 1 |
A-8955 | H | H | H | H | H | O | H | H | 2-(2-氯乙炔基) | 1 |
A-8956 | H | H | H | H | H | O | H | H | 3-(2-氯乙炔基) | 1 |
A-8957 | H | H | H | H | H | O | H | H | 4-(2-氯乙炔基) | 1 |
A-8958 | H | H | H | H | H | O | H | H | 2-(2-溴乙炔基) | 1 |
A-8959 | H | H | H | H | H | O | H | H | 3-(2-溴乙炔基) | 1 |
A-8960 | H | H | H | H | H | O | H | H | 4-(2-溴乙炔基) | 1 |
A-8961 | H | H | H | H | H | O | H | H | 2-OMe | 1 |
A-8962 | H | H | H | H | H | O | H | H | 3-OMe | 1 |
A-8963 | H | H | H | H | H | O | H | H | 4-OMe | 1 |
A-8964 | H | H | H | H | H | O | H | H | 2-OEt | 1 |
A-8965 | H | H | H | H | H | O | H | H | 3-OEt | 1 |
A-8966 | H | H | H | H | H | O | H | H | 4-OEt | 1 |
A-8967 | H | H | H | H | H | O | H | H | 2-OPr | 1 |
A-8968 | H | H | H | H | H | O | H | H | 3-OPr | 1 |
A-8969 | H | H | H | H | H | O | H | H | 4-OPr | 1 |
A-8970 | H | H | H | H | H | O | H | H | 2-O(i-Pr) | 1 |
A-8971 | H | H | H | H | H | O | H | H | 3-O(i-Pr) | 1 |
A-8972 | H | H | H | H | H | O | H | H | 4-O(i-Pr) | 1 |
A-8973 | H | H | H | H | H | O | H | H | 2-OBu | 1 |
A-8974 | H | H | H | H | H | O | H | H | 3-OBu | 1 |
A-8975 | H | H | H | H | H | O | H | H | 4-OBu | 1 |
A-8976 | H | H | H | H | H | O | H | H | 2-O(s-Bu) | 1 |
A-8977 | H | H | H | H | H | O | H | H | 3-O(s-Bu) | 1 |
A-8978 | H | H | H | H | H | O | H | H | 4-O(s-Bu) | 1 |
A-8979 | H | H | H | H | H | O | H | H | 2-O(i-Bu) | 1 |
A-8980 | H | H | H | H | H | O | H | H | 3-O(i-Bu) | 1 |
A-8981 | H | H | H | H | H | O | H | H | 4-O(i-Bu) | 1 |
A-8982 | H | H | H | H | H | O | H | H | 2-O(t-Bu) | 1 |
A-8983 | H | H | H | H | H | O | H | H | 3-O(t-Bu) | 1 |
A-8984 | H | H | H | H | H | O | H | H | 4-O(t-Bu) | 1 |
A-8985 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub> | 1 |
A-8986 | H | H | H | H | H | O | H | H | 3-OCF<sub>3</sub> | 1 |
A-8987 | H | H | H | H | H | O | H | H | 4-OCF<sub>3</sub> | 1 |
A-8988 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub> | 1 |
A-8989 | H | H | H | H | H | O | H | H | 3-OCHF<sub>2</sub> | 1 |
A-8990 | H | H | H | H | H | O | H | H | 4-OCHF<sub>2</sub> | 1 |
A-8991 | H | H | H | H | H | O | H | H | 2-OCH<sub>2</sub>CF<sub>3</sub> | 1 |
A-8992 | H | H | H | H | H | O | H | H | 3-OCH<sub>2</sub>CF<sub>3</sub> | 1 |
A-8993 | H | H | H | H | H | O | H | H | 4-OCH<sub>2</sub>CF<sub>3</sub> | 1 |
A-8994 | H | H | H | H | H | O | H | H | 2-(环丙基氧基) | 1 |
A-8995 | H | H | H | H | H | O | H | H | 3-(环丙基氧基) | 1 |
A-8996 | H | H | H | H | H | O | H | H | 4-(环丙基氧基) | 1 |
A-8997 | H | H | H | H | H | O | H | H | 2-(环丁基氧基) | 1 |
A-8998 | H | H | H | H | H | O | H | H | 3-(环丁基氧基) | 1 |
A-8999 | H | H | H | H | H | O | H | H | 4-(环丁基氧基) | 1 |
A-9000 | H | H | H | H | H | O | H | H | 2-(环戊基氧基) | 1 |
A-9001 | H | H | H | H | H | O | H | H | 3-(环戊基氧基) | 1 |
[表159]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9002 | H | H | H | H | H | O | H | H | 4-(环戊基氧基) | 1 |
A-9003 | H | H | H | H | H | O | H | H | 2-((2,2-二氯环丙基)氧基) | 1 |
A-9004 | H | H | H | H | H | O | H | H | 3-((2,2-二氯环丙基)氧基) | 1 |
A-9005 | H | H | H | H | H | O | H | H | 4-((2,2-二氯环丙基)氧基) | 1 |
A-9006 | H | H | H | H | H | O | H | H | 2-(环丙基甲氧基) | 1 |
A-9007 | H | H | H | H | H | O | H | H | 3-(环丙基甲氧基) | 1 |
A-9008 | H | H | H | H | H | O | H | H | 4-(环丙基甲氧基) | 1 |
A-9009 | H | H | H | H | H | O | H | H | 2-((2,2-二氟环丙基)甲氧基) | 1 |
A-9010 | H | H | H | H | H | O | H | H | 3-((2,2-二氟环丙基)甲氧基) | 1 |
A-9011 | H | H | H | H | H | O | H | H | 4-((2,2-二氟环丙基)甲氧基) | 1 |
A-9012 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基) | 1 |
A-9013 | H | H | H | H | H | O | H | H | 3-(环氧乙烷-2-基) | 1 |
A-9014 | H | H | H | H | H | O | H | H | 4-(环氧乙烷-2-基) | 1 |
A-9015 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基) | 1 |
A-9016 | H | H | H | H | H | O | H | H | 3-(环氧乙烷-2-基甲基) | 1 |
A-9017 | H | H | H | H | H | O | H | H | 4-(环氧乙烷-2-基甲基) | 1 |
A-9018 | H | H | H | H | H | O | H | H | 2-SMe | 1 |
A-9019 | H | H | H | H | H | O | H | H | 3-SMe | 1 |
A-9020 | H | H | H | H | H | O | H | H | 4-SMe | 1 |
A-9021 | H | H | H | H | H | O | H | H | 2-SEt | 1 |
A-9022 | H | H | H | H | H | O | H | H | 3-SEt | 1 |
A-9023 | H | H | H | H | H | O | H | H | 4-SEt | 1 |
A-9024 | H | H | H | H | H | O | H | H | 2-S(=O)Me | 1 |
A-9025 | H | H | H | H | H | O | H | H | 3-S(=O)Me | 1 |
A-9026 | H | H | H | H | H | O | H | H | 4-S(=O)Me | 1 |
A-9027 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me | 1 |
A-9028 | H | H | H | H | H | O | H | H | 3-S(=O)<sub>2</sub>Me | 1 |
A-9029 | H | H | H | H | H | O | H | H | 4-S(=O)<sub>2</sub>Me | 1 |
A-9030 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub> | 1 |
A-9031 | H | H | H | H | H | O | H | H | 3-SCF<sub>3</sub> | 1 |
A-9032 | H | H | H | H | H | O | H | H | 4-SCF<sub>3</sub> | 1 |
A-9033 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub> | 1 |
A-9034 | H | H | H | H | H | O | H | H | 3-S(=O)CF<sub>3</sub> | 1 |
A-9035 | H | H | H | H | H | O | H | H | 4-S(=O)CF<sub>3</sub> | 1 |
A-9036 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
A-9037 | H | H | H | H | H | O | H | H | 3-S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
A-9038 | H | H | H | H | H | O | H | H | 4-S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
A-9039 | H | H | H | H | H | O | H | H | 2-SCF(CF<sub>3</sub>)<sub>2</sub> | 1 |
A-9040 | H | H | H | H | H | O | H | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 1 |
A-9041 | H | H | H | H | H | O | H | H | 4-SCF(CF<sub>3</sub>)<sub>2</sub> | 1 |
A-9042 | H | H | H | H | H | O | H | H | 2-(环丙基硫基) | 1 |
A-9043 | H | H | H | H | H | O | H | H | 3-(环丙基硫基) | 1 |
A-9044 | H | H | H | H | H | O | H | H | 4-(环丙基硫基) | 1 |
A-9045 | H | H | H | H | H | O | H | H | 2-(环丙基亚磺酰基) | 1 |
A-9046 | H | H | H | H | H | O | H | H | 3-(环丙基亚磺酰基) | 1 |
A-9047 | H | H | H | H | H | O | H | H | 4-(环丙基亚磺酰基) | 1 |
A-9048 | H | H | H | H | H | O | H | H | 2-(环丙基磺酰基) | 1 |
A-9049 | H | H | H | H | H | O | H | H | 3-(环丙基磺酰基) | 1 |
A-9050 | H | H | H | H | H | O | H | H | 4-(环丙基磺酰基) | 1 |
A-9051 | H | H | H | H | H | O | H | H | 2-((环丙基甲基)硫基) | 1 |
A-9052 | H | H | H | H | H | O | H | H | 3-((环丙基甲基)硫基) | 1 |
A-9053 | H | H | H | H | H | O | H | H | 4-((环丙基甲基)硫基) | 1 |
A-9054 | H | H | H | H | H | O | H | H | 2-((环丙基甲基)亚磺酰基) | 1 |
A-9055 | H | H | H | H | H | O | H | H | 3-((环丙基甲基)亚磺酰基) | 1 |
A-9056 | H | H | H | H | H | O | H | H | 4-((环丙基甲基)亚磺酰基) | 1 |
A-9057 | H | H | H | H | H | O | H | H | 2-((环丙基甲基)磺酰基) | 1 |
A-9058 | H | H | H | H | H | O | H | H | 3-((环丙基甲基)磺酰基) | 1 |
[表160]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9059 | H | H | H | H | H | O | H | H | 4-((环丙基甲基)磺酰基) | 1 |
A-9060 | H | H | H | H | H | O | H | H | 2-(((2,2-二氟环丙基)甲基)硫基) | 1 |
A-9061 | H | H | H | H | H | O | H | H | 3-(((2,2-二氟环丙基)甲基)硫基) | 1 |
A-9062 | H | H | H | H | H | O | H | H | 4-(((2,2-二氟环丙基)甲基)硫基) | 1 |
A-9063 | H | H | H | H | H | O | H | H | 2-(((2,2-二氟环丙基)甲基)亚磺酰基) | 1 |
A-9064 | H | H | H | H | H | O | H | H | 3-(((2,2-二氟环丙基)甲基)亚磺酰基) | 1 |
A-9065 | H | H | H | H | H | O | H | H | 4-(((2,2-二氟环丙基)甲基)亚磺酰基) | 1 |
A-9066 | H | H | H | H | H | O | H | H | 2-(((2,2-二氟环丙基)甲基)磺酰基) | 1 |
A-9067 | H | H | H | H | H | O | H | H | 3-(((2,2-二氟环丙基)甲基)磺酰基) | 1 |
A-9068 | H | H | H | H | H | O | H | H | 4-(((2,2-二氟环丙基)甲基)磺酰基) | 1 |
A-9069 | H | H | H | H | H | O | H | H | 2-C(=O)Me | 1 |
A-9070 | H | H | H | H | H | O | H | H | 3-C(=O)Me | 1 |
A-9071 | H | H | H | H | H | O | H | H | 4-C(=O)Me | 1 |
A-9072 | H | H | H | H | H | O | H | H | 2-C(=O)Et | 1 |
A-9073 | H | H | H | H | H | O | H | H | 3-C(=O)Et | 1 |
A-9074 | H | H | H | H | H | O | H | H | 4-C(=O)Et | 1 |
A-9075 | H | H | H | H | H | O | H | H | 2-C(=O)CF<sub>3</sub> | 1 |
A-9076 | H | H | H | H | H | O | H | H | 3-C(=O)CF<sub>3</sub> | 1 |
A-9077 | H | H | H | H | H | O | H | H | 4-C(=O)CF<sub>3</sub> | 1 |
A-9078 | H | H | H | H | H | O | H | H | 2-C(=O)OMe | 1 |
A-9079 | H | H | H | H | H | O | H | H | 3-C(=O)OMe | 1 |
A-9080 | H | H | H | H | H | O | H | H | 4-C(=O)OMe | 1 |
A-9081 | H | H | H | H | H | O | H | H | 2-C(=O)OEt | 1 |
A-9082 | H | H | H | H | H | O | H | H | 3-C(=O)OEt | 1 |
A-9083 | H | H | H | H | H | O | H | H | 4-C(=O)OEt | 1 |
A-9084 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub> | 1 |
A-9085 | H | H | H | H | H | O | H | H | 3-C(=O)NH<sub>2</sub> | 1 |
A-9086 | H | H | H | H | H | O | H | H | 4-C(=O)NH<sub>2</sub> | 1 |
A-9087 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe | 1 |
A-9088 | H | H | H | H | H | O | H | H | 3-C(=O)NHMe | 1 |
A-9089 | H | H | H | H | H | O | H | H | 4-C(=O)NHMe | 1 |
A-9090 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub> | 1 |
A-9091 | H | H | H | H | H | O | H | H | 3-C(=O)NMe<sub>2</sub> | 1 |
A-9092 | H | H | H | H | H | O | H | H | 4-C(=O)NMe<sub>2</sub> | 1 |
A-9093 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 1 |
A-9094 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 1 |
A-9095 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 1 |
A-9096 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 1 |
A-9097 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 1 |
A-9098 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 1 |
A-9099 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 1 |
A-9100 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 1 |
A-9101 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 1 |
A-9102 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH | 1 |
A-9103 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OH | 1 |
A-9104 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OH | 1 |
A-9105 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 1 |
A-9106 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OCH<sub>3</sub> | 1 |
A-9107 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OCH<sub>3</sub> | 1 |
A-9108 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 1 |
A-9109 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 1 |
A-9110 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 1 |
A-9111 | H | H | H | H | H | O | H | H | 2-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 1 |
A-9112 | H | H | H | H | H | O | H | H | 3-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 1 |
A-9113 | H | H | H | H | H | O | H | H | 4-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 1 |
A-9114 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 1 |
A-9115 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 1 |
[表161]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9116 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 1 |
A-9117 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCF<sub>3</sub> | 1 |
A-9118 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OCF<sub>3</sub> | 1 |
A-9119 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OCF<sub>3</sub> | 1 |
A-9120 | H | H | H | H | H | O | H | H | 2-CF<sub>2</sub>OCH<sub>3</sub> | 1 |
A-9121 | H | H | H | H | H | O | H | H | 3-CF<sub>2</sub>OCH<sub>3</sub> | 1 |
A-9122 | H | H | H | H | H | O | H | H | 4-CF<sub>2</sub>OCH<sub>3</sub> | 1 |
A-9123 | H | H | H | H | H | O | H | H | 2-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 1 |
A-9124 | H | H | H | H | H | O | H | H | 3-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 1 |
A-9125 | H | H | H | H | H | O | H | H | 4-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 1 |
A-9126 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub> | 1 |
A-9127 | H | H | H | H | H | O | H | H | 3-OC(=O)CH<sub>3</sub> | 1 |
A-9128 | H | H | H | H | H | O | H | H | 4-OC(=O)CH<sub>3</sub> | 1 |
A-9129 | H | H | H | H | H | O | H | H | 2-OC(=O)CF<sub>3</sub> | 1 |
A-9130 | H | H | H | H | H | O | H | H | 3-OC(=O)CF<sub>3</sub> | 1 |
A-9131 | H | H | H | H | H | O | H | H | 4-OC(=O)CF<sub>3</sub> | 1 |
A-9132 | H | H | H | H | H | O | H | H | 2-OC(=O)NH<sub>2</sub> | 1 |
A-9133 | H | H | H | H | H | O | H | H | 3-OC(=O)NH<sub>2</sub> | 1 |
A-9134 | H | H | H | H | H | O | H | H | 4-OC(=O)NH<sub>2</sub> | 1 |
A-9135 | H | H | H | H | H | O | H | H | 2-OC(=O)NHCH<sub>3</sub> | 1 |
A-9136 | H | H | H | H | H | O | H | H | 3-OC(=O)NHCH<sub>3</sub> | 1 |
A-9137 | H | H | H | H | H | O | H | H | 4-OC(=O)NHCH<sub>3</sub> | 1 |
A-9138 | H | H | H | H | H | O | H | H | 2-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
A-9139 | H | H | H | H | H | O | H | H | 3-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
A-9140 | H | H | H | H | H | O | H | H | 4-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
A-9141 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 1 |
A-9142 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 1 |
A-9143 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 1 |
A-9144 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 1 |
A-9145 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 1 |
A-9146 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 1 |
A-9147 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
A-9148 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
A-9149 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
A-9150 | H | H | H | H | H | O | H | H | 2-OC(=O)OCH<sub>3</sub> | 1 |
A-9151 | H | H | H | H | H | O | H | H | 3-OC(=O)OCH<sub>3</sub> | 1 |
A-9152 | H | H | H | H | H | O | H | H | 4-OC(=O)OCH<sub>3</sub> | 1 |
A-9153 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 1 |
A-9154 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 1 |
A-9155 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 1 |
A-9156 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 1 |
A-9157 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 1 |
A-9158 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 1 |
A-9159 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
A-9160 | H | H | H | H | H | O | H | H | 3-OS(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
A-9161 | H | H | H | H | H | O | H | H | 4-OS(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
A-9162 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
A-9163 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
A-9164 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
A-9165 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 1 |
A-9166 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 1 |
A-9167 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 1 |
A-9168 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
A-9169 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
A-9170 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
A-9171 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub> | 1 |
A-9172 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>SCF<sub>3</sub> | 1 |
[表162]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9173 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>SCF<sub>3</sub> | 1 |
A-9174 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 1 |
A-9175 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 1 |
A-9176 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 1 |
A-9177 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
A-9178 | H | H | H | H | H | O | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
A-9179 | H | H | H | H | H | O | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
A-9180 | H | H | H | H | H | O | H | H | 2-苯基 | 1 |
A-9181 | H | H | H | H | H | O | H | H | 3-苯基 | 1 |
A-9182 | H | H | H | H | H | O | H | H | 4-苯基 | 1 |
A-9183 | H | H | H | H | H | O | H | H | 2-(苯氧基) | 1 |
A-9184 | H | H | H | H | H | O | H | H | 3-(苯氧基) | 1 |
A-9185 | H | H | H | H | H | O | H | H | 4-(苯氧基) | 1 |
A-9186 | H | H | H | H | H | O | H | H | 2-苯甲基 | 1 |
A-9187 | H | H | H | H | H | O | H | H | 3-苯甲基 | 1 |
A-9188 | H | H | H | H | H | O | H | H | 4-苯甲基 | 1 |
A-9189 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基) | 1 |
A-9190 | H | H | H | H | H | O | H | H | 3-(苯甲基氧基) | 1 |
A-9191 | H | H | H | H | H | O | H | H | 4-(苯甲基氧基) | 1 |
A-9192 | H | H | H | H | H | O | H | H | 2-((2-氟苯甲基)氧基) | 1 |
A-9193 | H | H | H | H | H | O | H | H | 3-((2-氟苯甲基)氧基) | 1 |
A-9194 | H | H | H | H | H | O | H | H | 4-((2-氟苯甲基)氧基) | 1 |
A-9195 | H | H | H | H | H | O | H | H | 2-((3-氟苯甲基)氧基) | 1 |
A-9196 | H | H | H | H | H | O | H | H | 3-((3-氟苯甲基)氧基) | 1 |
A-9197 | H | H | H | H | H | O | H | H | 4-((3-氟苯甲基)氧基) | 1 |
A-9198 | H | H | H | H | H | O | H | H | 2-((4-氟苯甲基)氧基) | 1 |
A-9199 | H | H | H | H | H | O | H | H | 3-((4-氟苯甲基)氧基) | 1 |
A-9200 | H | H | H | H | H | O | H | H | 4-((4-氟苯甲基)氧基) | 1 |
A-9201 | H | H | H | H | H | O | H | H | 2-((2-氯苯甲基)氧基) | 1 |
A-9202 | H | H | H | H | H | O | H | H | 3-((2-氯苯甲基)氧基) | 1 |
A-9203 | H | H | H | H | H | O | H | H | 4-((2-氯苯甲基)氧基) | 1 |
A-9204 | H | H | H | H | H | O | H | H | 2-((3-氯苯甲基)氧基) | 1 |
A-9205 | H | H | H | H | H | O | H | H | 3-((3-氯苯甲基)氧基) | 1 |
A-9206 | H | H | H | H | H | O | H | H | 4-((3-氯苯甲基)氧基) | 1 |
A-9207 | H | H | H | H | H | O | H | H | 2-((4-氯苯甲基)氧基) | 1 |
A-9208 | H | H | H | H | H | O | H | H | 3-((4-氯苯甲基)氧基) | 1 |
A-9209 | H | H | H | H | H | O | H | H | 4-((4-氯苯甲基)氧基) | 1 |
A-9210 | H | H | H | H | H | O | H | H | 2-((2-甲基苯甲基)氧基) | 1 |
A-9211 | H | H | H | H | H | O | H | H | 3-((2-甲基苯甲基)氧基) | 1 |
A-9212 | H | H | H | H | H | O | H | H | 4-((2-甲基苯甲基)氧基) | 1 |
A-9213 | H | H | H | H | H | O | H | H | 2-((3-甲基苯甲基)氧基) | 1 |
A-9214 | H | H | H | H | H | O | H | H | 3-((3-甲基苯甲基)氧基) | 1 |
A-9215 | H | H | H | H | H | O | H | H | 4-((3-甲基苯甲基)氧基) | 1 |
A-9216 | H | H | H | H | H | O | H | H | 2-((4-甲基苯甲基)氧基) | 1 |
A-9217 | H | H | H | H | H | O | H | H | 3-((4-甲基苯甲基)氧基) | 1 |
A-9218 | H | H | H | H | H | O | H | H | 4-((4-甲基苯甲基)氧基) | 1 |
A-9219 | H | H | H | H | H | O | H | H | 2-((2-(三氟甲基)苯甲基)氧基) | 1 |
A-9220 | H | H | H | H | H | O | H | H | 3-((2-(三氟甲基)苯甲基)氧基) | 1 |
A-9221 | H | H | H | H | H | O | H | H | 4-((2-(三氟甲基)苯甲基)氧基) | 1 |
A-9222 | H | H | H | H | H | O | H | H | 2-((3-(三氟甲基)苯甲基)氧基) | 1 |
A-9223 | H | H | H | H | H | O | H | H | 3-((3-(三氟甲基)苯甲基)氧基) | 1 |
A-9224 | H | H | H | H | H | O | H | H | 4-((3-(三氟甲基)苯甲基)氧基) | 1 |
A-9225 | H | H | H | H | H | O | H | H | 2-((4-(三氟甲基)苯甲基)氧基) | 1 |
A-9226 | H | H | H | H | H | O | H | H | 3-((4-(三氟甲基)苯甲基)氧基) | 1 |
A-9227 | H | H | H | H | H | O | H | H | 4-((4-(三氟甲基)苯甲基)氧基) | 1 |
A-9228 | H | H | H | H | H | O | H | H | 2-((2-甲氧基苯甲基)氧基) | 1 |
A-9229 | H | H | H | H | H | O | H | H | 3-((2-甲氧基苯甲基)氧基) | 1 |
[表163]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9230 | H | H | H | H | H | O | H | H | 4-((2-甲氧基苯甲基)氧基) | 1 |
A-9231 | H | H | H | H | H | O | H | H | 2-((3-甲氧基苯甲基)氧基) | 1 |
A-9232 | H | H | H | H | H | O | H | H | 3-((3-甲氧基苯甲基)氧基) | 1 |
A-9233 | H | H | H | H | H | O | H | H | 4-((3-甲氧基苯甲基)氧基) | 1 |
A-9234 | H | H | H | H | H | O | H | H | 2-((4-甲氧基苯甲基)氧基) | 1 |
A-9235 | H | H | H | H | H | O | H | H | 3-((4-甲氧基苯甲基)氧基) | 1 |
A-9236 | H | H | H | H | H | O | H | H | 4-((4-甲氧基苯甲基)氧基) | 1 |
A-9237 | H | H | H | H | H | O | H | H | 2-((2-(三氟甲氧基)苯甲基)氧基) | 1 |
A-9238 | H | H | H | H | H | O | H | H | 3-((2-(三氟甲氧基)苯甲基)氧基) | 1 |
A-9239 | H | H | H | H | H | O | H | H | 4-((2-(三氟甲氧基)苯甲基)氧基) | 1 |
A-9240 | H | H | H | H | H | O | H | H | 2-((3-(三氟甲氧基)苯甲基)氧基) | 1 |
A-9241 | H | H | H | H | H | O | H | H | 3-((3-(三氟甲氧基)苯甲基)氧基) | 1 |
A-9242 | H | H | H | H | H | O | H | H | 4-((3-(三氟甲氧基)苯甲基)氧基) | 1 |
A-9243 | H | H | H | H | H | O | H | H | 2-((4-(三氟甲氧基)苯甲基)氧基) | 1 |
A-9244 | H | H | H | H | H | O | H | H | 3-((4-(三氟甲氧基)苯甲基)氧基) | 1 |
A-9245 | H | H | H | H | H | O | H | H | 4-((4-(三氟甲氧基)苯甲基)氧基) | 1 |
A-9246 | H | H | H | H | H | O | H | H | 2-((2-(甲基硫基)苯甲基)氧基) | 1 |
A-9247 | H | H | H | H | H | O | H | H | 3-((2-(甲基硫基)苯甲基)氧基) | 1 |
A-9248 | H | H | H | H | H | O | H | H | 4-((2-(甲基硫基)苯甲基)氧基) | 1 |
A-9249 | H | H | H | H | H | O | H | H | 2-((3-(甲基硫基)苯甲基)氧基) | 1 |
A-9250 | H | H | H | H | H | O | H | H | 3-((3-(甲基硫基)苯甲基)氧基) | 1 |
A-9251 | H | H | H | H | H | O | H | H | 4-((3-(甲基硫基)苯甲基)氧基) | 1 |
A-9252 | H | H | H | H | H | O | H | H | 2-((4-(甲基硫基)苯甲基)氧基) | 1 |
A-9253 | H | H | H | H | H | O | H | H | 3-((4-(甲基硫基)苯甲基)氧基) | 1 |
A-9254 | H | H | H | H | H | O | H | H | 4-((4-(甲基硫基)苯甲基)氧基) | 1 |
A-9255 | H | H | H | H | H | O | H | H | 2-((2-(甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9256 | H | H | H | H | H | O | H | H | 3-((2-(甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9257 | H | H | H | H | H | O | H | H | 4-((2-(甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9258 | H | H | H | H | H | O | H | H | 2-((3-(甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9259 | H | H | H | H | H | O | H | H | 3-((3-(甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9260 | H | H | H | H | H | O | H | H | 4-((3-(甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9261 | H | H | H | H | H | O | H | H | 2-((4-(甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9262 | H | H | H | H | H | O | H | H | 3-((4-(甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9263 | H | H | H | H | H | O | H | H | 4-((4-(甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9264 | H | H | H | H | H | O | H | H | 2-((2-(甲基磺酰基)苯甲基)氧基) | 1 |
A-9265 | H | H | H | H | H | O | H | H | 3-((2-(甲基磺酰基)苯甲基)氧基) | 1 |
A-9266 | H | H | H | H | H | O | H | H | 4-((2-(甲基磺酰基)苯甲基)氧基) | 1 |
A-9267 | H | H | H | H | H | O | H | H | 2-((3-(甲基磺酰基)苯甲基)氧基) | 1 |
A-9268 | H | H | H | H | H | O | H | H | 3-((3-(甲基磺酰基)苯甲基)氧基) | 1 |
A-9269 | H | H | H | H | H | O | H | H | 4-((3-(甲基磺酰基)苯甲基)氧基) | 1 |
A-9270 | H | H | H | H | H | O | H | H | 2-((4-(甲基磺酰基)苯甲基)氧基) | 1 |
A-9271 | H | H | H | H | H | O | H | H | 3-((4-(甲基磺酰基)苯甲基)氧基) | 1 |
A-9272 | H | H | H | H | H | O | H | H | 4-((4-(甲基磺酰基)苯甲基)氧基) | 1 |
A-9273 | H | H | H | H | H | O | H | H | 2-((2-(三氟甲基硫基)苯甲基)氧基) | 1 |
A-9274 | H | H | H | H | H | O | H | H | 3-((2-(三氟甲基硫基)苯甲基)氧基) | 1 |
A-9275 | H | H | H | H | H | O | H | H | 4-((2-(三氟甲基硫基)苯甲基)氧基) | 1 |
A-9276 | H | H | H | H | H | O | H | H | 2-((3-(三氟甲基硫基)苯甲基)氧基) | 1 |
A-9277 | H | H | H | H | H | O | H | H | 3-((3-(三氟甲基硫基)苯甲基)氧基) | 1 |
A-9278 | H | H | H | H | H | O | H | H | 4-((3-(三氟甲基硫基)苯甲基)氧基) | 1 |
A-9279 | H | H | H | H | H | O | H | H | 2-((4-(三氟甲基硫基)苯甲基)氧基) | 1 |
A-9280 | H | H | H | H | H | O | H | H | 3-((4-(三氟甲基硫基)苯甲基)氧基) | 1 |
A-9281 | H | H | H | H | H | O | H | H | 4-((4-(三氟甲基硫基)苯甲基)氧基) | 1 |
A-9282 | H | H | H | H | H | O | H | H | 2-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9283 | H | H | H | H | H | O | H | H | 3-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9284 | H | H | H | H | H | O | H | H | 4-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9285 | H | H | H | H | H | O | H | H | 2-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9286 | H | H | H | H | H | O | H | H | 3-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
[表164]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9287 | H | H | H | H | H | O | H | H | 4-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9288 | H | H | H | H | H | O | H | H | 2-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9289 | H | H | H | H | H | O | H | H | 3-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9290 | H | H | H | H | H | O | H | H | 4-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
A-9291 | H | H | H | H | H | O | H | H | 2-((2-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
A-9292 | H | H | H | H | H | O | H | H | 3-((2-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
A-9293 | H | H | H | H | H | O | H | H | 4-((2-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
A-9294 | H | H | H | H | H | O | H | H | 2-((3-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
A-9295 | H | H | H | H | H | O | H | H | 3-((3-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
A-9296 | H | H | H | H | H | O | H | H | 4-((3-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
A-9297 | H | H | H | H | H | O | H | H | 2-((4-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
A-9298 | H | H | H | H | H | O | H | H | 3-((4-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
A-9299 | H | H | H | H | H | O | H | H | 4-((4-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
A-9300 | H | H | H | H | H | O | H | H | 2-((2-氨基苯甲基)氧基) | 1 |
A-9301 | H | H | H | H | H | O | H | H | 3-((2-氨基苯甲基)氧基) | 1 |
A-9302 | H | H | H | H | H | O | H | H | 4-((2-氨基苯甲基)氧基) | 1 |
A-9303 | H | H | H | H | H | O | H | H | 2-((3-氨基苯甲基)氧基) | 1 |
A-9304 | H | H | H | H | H | O | H | H | 3-((3-氨基苯甲基)氧基) | 1 |
A-9305 | H | H | H | H | H | O | H | H | 4-((3-氨基苯甲基)氧基) | 1 |
A-9306 | H | H | H | H | H | O | H | H | 2-((4-氨基苯甲基)氧基) | 1 |
A-9307 | H | H | H | H | H | O | H | H | 3-((4-氨基苯甲基)氧基) | 1 |
A-9308 | H | H | H | H | H | O | H | H | 4-((4-氨基苯甲基)氧基) | 1 |
A-9309 | H | H | H | H | H | O | H | H | 2-((2-(甲基氨基)苯甲基)氧基) | 1 |
A-9310 | H | H | H | H | H | O | H | H | 3-((2-(甲基氨基)苯甲基)氧基) | 1 |
A-9311 | H | H | H | H | H | O | H | H | 4-((2-(甲基氨基)苯甲基)氧基) | 1 |
A-9312 | H | H | H | H | H | O | H | H | 2-((3-(甲基氨基)苯甲基)氧基) | 1 |
A-9313 | H | H | H | H | H | O | H | H | 3-((3-(甲基氨基)苯甲基)氧基) | 1 |
A-9314 | H | H | H | H | H | O | H | H | 4-((3-(甲基氨基)苯甲基)氧基) | 1 |
A-9315 | H | H | H | H | H | O | H | H | 2-((4-(甲基氨基)苯甲基)氧基) | 1 |
A-9316 | H | H | H | H | H | O | H | H | 3-((4-(甲基氨基)苯甲基)氧基) | 1 |
A-9317 | H | H | H | H | H | O | H | H | 4-((4-(甲基氨基)苯甲基)氧基) | 1 |
A-9318 | H | H | H | H | H | O | H | H | 2-((2-(二甲基氨基)苯甲基)氧基) | 1 |
A-9319 | H | H | H | H | H | O | H | H | 3-((2-(二甲基氨基)苯甲基)氧基) | 1 |
A-9320 | H | H | H | H | H | O | H | H | 4-((2-(二甲基氨基)苯甲基)氧基) | 1 |
A-9321 | H | H | H | H | H | O | H | H | 2-((3-(二甲基氨基)苯甲基)氧基) | 1 |
A-9322 | H | H | H | H | H | O | H | H | 3-((3-(二甲基氨基)苯甲基)氧基) | 1 |
A-9323 | H | H | H | H | H | O | H | H | 4-((3-(二甲基氨基)苯甲基)氧基) | 1 |
A-9324 | H | H | H | H | H | O | H | H | 2-((4-(二甲基氨基)苯甲基)氧基) | 1 |
A-9325 | H | H | H | H | H | O | H | H | 3-((4-(二甲基氨基)苯甲基)氧基) | 1 |
A-9326 | H | H | H | H | H | O | H | H | 4-((4-(二甲基氨基)苯甲基)氧基) | 1 |
A-9327 | H | H | H | H | H | O | H | H | 2-((2-氰基苯甲基)氧基) | 1 |
A-9328 | H | H | H | H | H | O | H | H | 3-((2-氰基苯甲基)氧基) | 1 |
A-9329 | H | H | H | H | H | O | H | H | 4-((2-氰基苯甲基)氧基) | 1 |
A-9330 | H | H | H | H | H | O | H | H | 2-((3-氰基苯甲基)氧基) | 1 |
A-9331 | H | H | H | H | H | O | H | H | 3-((3-氰基苯甲基)氧基) | 1 |
A-9332 | H | H | H | H | H | O | H | H | 4-((3-氰基苯甲基)氧基) | 1 |
A-9333 | H | H | H | H | H | O | H | H | 2-((4-氰基苯甲基)氧基) | 1 |
A-9334 | H | H | H | H | H | O | H | H | 3-((4-氰基苯甲基)氧基) | 1 |
A-9335 | H | H | H | H | H | O | H | H | 4-((4-氰基苯甲基)氧基) | 1 |
A-9336 | H | H | H | H | H | O | H | H | 2-((2-硝基苯甲基)氧基) | 1 |
A-9337 | H | H | H | H | H | O | H | H | 3-((2-硝基苯甲基)氧基) | 1 |
A-9338 | H | H | H | H | H | O | H | H | 4-((2-硝基苯甲基)氧基) | 1 |
A-9339 | H | H | H | H | H | O | H | H | 2-((3-硝基苯甲基)氧基) | 1 |
A-9340 | H | H | H | H | H | O | H | H | 3-((3-硝基苯甲基)氧基) | 1 |
A-9341 | H | H | H | H | H | O | H | H | 4-((3-硝基苯甲基)氧基) | 1 |
A-9342 | H | H | H | H | H | O | H | H | 2-((4-硝基苯甲基)氧基) | 1 |
A-9343 | H | H | H | H | H | O | H | H | 3-((4-硝基苯甲基)氧基) | 1 |
[表165]
[表166]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9401 | H | H | H | H | H | O | H | H | 3,5-F<sub>2</sub> | 1 |
A-9402 | H | H | H | H | H | O | H | H | 2-F,3-Cl | 1 |
A-9403 | H | H | H | H | H | O | H | H | 2-F,4-Cl | 1 |
A-9404 | H | H | H | H | H | O | H | H | 2-F,5-Cl | 1 |
A-9405 | H | H | H | H | H | O | H | H | 2-F,6-Cl | 1 |
A-9406 | H | H | H | H | H | O | H | H | 3-F,2-Cl | 1 |
A-9407 | H | H | H | H | H | O | H | H | 3-F,4-Cl | 1 |
A-9408 | H | H | H | H | H | O | H | H | 3-F,5-Cl | 1 |
A-9409 | H | H | H | H | H | O | H | H | 3-F,6-Cl | 1 |
A-9410 | H | H | H | H | H | O | H | H | 4-F,2-Cl | 1 |
A-9411 | H | H | H | H | H | O | H | H | 4-F,3-Cl | 1 |
A-9412 | H | H | H | H | H | O | H | H | 2-F,3-Me | 1 |
A-9413 | H | H | H | H | H | O | H | H | 2-F,4-Me | 1 |
A-9414 | H | H | H | H | H | O | H | H | 2-F,5-Me | 1 |
A-9415 | H | H | H | H | H | O | H | H | 2-F,6-Me | 1 |
A-9416 | H | H | H | H | H | O | H | H | 3-F,2-Me | 1 |
A-9417 | H | H | H | H | H | O | H | H | 3-F,4-Me | 1 |
A-9418 | H | H | H | H | H | O | H | H | 3-F,5-Me | 1 |
A-9419 | H | H | H | H | H | O | H | H | 3-F,6-Me | 1 |
A-9420 | H | H | H | H | H | O | H | H | 4-F,2-Me | 1 |
A-9421 | H | H | H | H | H | O | H | H | 4-F,3-Me | 1 |
A-9422 | H | H | H | H | H | O | H | H | 2-F,3-CF<sub>3</sub> | 1 |
A-9423 | H | H | H | H | H | O | H | H | 2-F,4-CF<sub>3</sub> | 1 |
A-9424 | H | H | H | H | H | O | H | H | 2-F,5-CF<sub>3</sub> | 1 |
A-9425 | H | H | H | H | H | O | H | H | 2-F,6-CF<sub>3</sub> | 1 |
A-9426 | H | H | H | H | H | O | H | H | 3-F,2-CF<sub>3</sub> | 1 |
A-9427 | H | H | H | H | H | O | H | H | 3-F,4-CF<sub>3</sub> | 1 |
A-9428 | H | H | H | H | H | O | H | H | 3-F,5-CF<sub>3</sub> | 1 |
A-9429 | H | H | H | H | H | O | H | H | 3-F,6-CF<sub>3</sub> | 1 |
A-9430 | H | H | H | H | H | O | H | H | 4-F,2-CF<sub>3</sub> | 1 |
A-9431 | H | H | H | H | H | O | H | H | 4-F,3-CF<sub>3</sub> | 1 |
A-9432 | H | H | H | H | H | O | H | H | 2-F,3-OMe | 1 |
A-9433 | H | H | H | H | H | O | H | H | 2-F,4-OMe | 1 |
A-9434 | H | H | H | H | H | O | H | H | 2-F,5-OMe | 1 |
A-9435 | H | H | H | H | H | O | H | H | 2-F,6-OMe | 1 |
A-9436 | H | H | H | H | H | O | H | H | 3-F,2-OMe | 1 |
A-9437 | H | H | H | H | H | O | H | H | 3-F,4-OMe | 1 |
A-9438 | H | H | H | H | H | O | H | H | 3-F,5-OMe | 1 |
A-9439 | H | H | H | H | H | O | H | H | 3-F,6-OMe | 1 |
A-9440 | H | H | H | H | H | O | H | H | 4-F,2-OMe | 1 |
A-9441 | H | H | H | H | H | O | H | H | 4-F,3-OMe | 1 |
A-9442 | H | H | H | H | H | O | H | H | 2,3-Cl<sub>2</sub> | 1 |
A-9443 | H | H | H | H | H | O | H | H | 2,4-Cl<sub>2</sub> | 1 |
A-9444 | H | H | H | H | H | O | H | H | 2,5-Cl<sub>2</sub> | 1 |
A-9445 | H | H | H | H | H | O | H | H | 2,6-Cl<sub>2</sub> | 1 |
A-9446 | H | H | H | H | H | O | H | H | 3,4-Cl<sub>2</sub> | 1 |
A-9447 | H | H | H | H | H | O | H | H | 3,5-Cl<sub>2</sub> | 1 |
A-9448 | H | H | H | H | H | O | H | H | 2-Cl,3-Me | 1 |
A-9449 | H | H | H | H | H | O | H | H | 2-Cl,4-Me | 1 |
A-9450 | H | H | H | H | H | O | H | H | 2-Cl,5-Me | 1 |
A-9451 | H | H | H | H | H | O | H | H | 2-Cl,6-Me | 1 |
A-9452 | H | H | H | H | H | O | H | H | 3-Cl,2-Me | 1 |
A-9453 | H | H | H | H | H | O | H | H | 3-Cl,4-Me | 1 |
A-9454 | H | H | H | H | H | O | H | H | 3-Cl,5-Me | 1 |
A-9455 | H | H | H | H | H | O | H | H | 3-Cl,6-Me | 1 |
A-9456 | H | H | H | H | H | O | H | H | 4-Cl,2-Me | 1 |
A-9457 | H | H | H | H | H | O | H | H | 4-Cl,3-Me | 1 |
[表167]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9458 | H | H | H | H | H | O | H | H | 2-Cl,3-CF<sub>3</sub> | 1 |
A-9459 | H | H | H | H | H | O | H | H | 2-Cl,4-CF<sub>3</sub> | 1 |
A-9460 | H | H | H | H | H | O | H | H | 2-Cl,5-CF<sub>3</sub> | 1 |
A-9461 | H | H | H | H | H | O | H | H | 2-Cl,6-CF<sub>3</sub> | 1 |
A-9462 | H | H | H | H | H | O | H | H | 3-Cl,2-CF<sub>3</sub> | 1 |
A-9463 | H | H | H | H | H | O | H | H | 3-Cl,4-CF<sub>3</sub> | 1 |
A-9464 | H | H | H | H | H | O | H | H | 3-Cl,5-CF<sub>3</sub> | 1 |
A-9465 | H | H | H | H | H | O | H | H | 3-Cl,6-CF<sub>3</sub> | 1 |
A-9466 | H | H | H | H | H | O | H | H | 4-Cl,2-CF<sub>3</sub> | 1 |
A-9467 | H | H | H | H | H | O | H | H | 4-Cl,3-CF<sub>3</sub> | 1 |
A-9468 | H | H | H | H | H | O | H | H | 2-Cl,3-OMe | 1 |
A-9469 | H | H | H | H | H | O | H | H | 2-Cl,4-OMe | 1 |
A-9470 | H | H | H | H | H | O | H | H | 2-Cl,5-OMe | 1 |
A-9471 | H | H | H | H | H | O | H | H | 2-Cl,6-OMe | 1 |
A-9472 | H | H | H | H | H | O | H | H | 3-Cl,2-OMe | 1 |
A-9473 | H | H | H | H | H | O | H | H | 3-Cl,4-OMe | 1 |
A-9474 | H | H | H | H | H | O | H | H | 3-Cl,5-OMe | 1 |
A-9475 | H | H | H | H | H | O | H | H | 3-Cl,6-OMe | 1 |
A-9476 | H | H | H | H | H | O | H | H | 4-Cl,2-OMe | 1 |
A-9477 | H | H | H | H | H | O | H | H | 4-Cl,3-OMe | 1 |
A-9478 | H | H | H | H | H | O | H | H | 2,3-Me<sub>2</sub> | 1 |
A-9479 | H | H | H | H | H | O | H | H | 2,4-Me<sub>2</sub> | 1 |
A-9480 | H | H | H | H | H | O | H | H | 2,5-Me<sub>2</sub> | 1 |
A-9481 | H | H | H | H | H | O | H | H | 2,6-Me<sub>2</sub> | 1 |
A-9482 | H | H | H | H | H | O | H | H | 3,4-Me<sub>2</sub> | 1 |
A-9483 | H | H | H | H | H | O | H | H | 3,5-Me<sub>2</sub> | 1 |
A-9484 | H | H | H | H | H | O | H | H | 2-Me,3-CF<sub>3</sub> | 1 |
A-9485 | H | H | H | H | H | O | H | H | 2-Me,4-CF<sub>3</sub> | 1 |
A-9486 | H | H | H | H | H | O | H | H | 2-Me,5-CF<sub>3</sub> | 1 |
A-9487 | H | H | H | H | H | O | H | H | 2-Me,6-CF<sub>3</sub> | 1 |
A-9488 | H | H | H | H | H | O | H | H | 3-Me,2-CF<sub>3</sub> | 1 |
A-9489 | H | H | H | H | H | O | H | H | 3-Me,4-CF<sub>3</sub> | 1 |
A-9490 | H | H | H | H | H | O | H | H | 3-Me,5-CF<sub>3</sub> | 1 |
A-9491 | H | H | H | H | H | O | H | H | 3-Me,6-CF<sub>3</sub> | 1 |
A-9492 | H | H | H | H | H | O | H | H | 4-Me,2-CF<sub>3</sub> | 1 |
A-9493 | H | H | H | H | H | O | H | H | 4-Me,3-CF<sub>3</sub> | 1 |
A-9494 | H | H | H | H | H | O | H | H | 2-Me,3-OMe | 1 |
A-9495 | H | H | H | H | H | O | H | H | 2-Me,4-OMe | 1 |
A-9496 | H | H | H | H | H | O | H | H | 2-Me,5-OMe | 1 |
A-9497 | H | H | H | H | H | O | H | H | 2-Me,6-OMe | 1 |
A-9498 | H | H | H | H | H | O | H | H | 3-Me,2-OMe | 1 |
A-9499 | H | H | H | H | H | O | H | H | 3-Me,4-OMe | 1 |
A-9500 | H | H | H | H | H | O | H | H | 3-Me,5-OMe | 1 |
A-9501 | H | H | H | H | H | O | H | H | 3-Me,6-OMe | 1 |
A-9502 | H | H | H | H | H | O | H | H | 4-Me,2-OMe | 1 |
A-9503 | H | H | H | H | H | O | H | H | 4-Me,3-OMe | 1 |
A-9504 | H | H | H | H | H | O | H | H | 2,3-OMe<sub>2</sub> | 1 |
A-9505 | H | H | H | H | H | O | H | H | 2,4-OMe<sub>2</sub> | 1 |
A-9506 | H | H | H | H | H | O | H | H | 2,5-OMe<sub>2</sub> | 1 |
A-9507 | H | H | H | H | H | O | H | H | 2,6-OMe<sub>2</sub> | 1 |
A-9508 | H | H | H | H | H | O | H | H | 3,4-OMe<sub>2</sub> | 1 |
A-9509 | H | H | H | H | H | O | H | H | 3,5-OMe<sub>2</sub> | 1 |
A-9510 | H | H | H | H | H | O | H | H | 2-OMe,3-CF<sub>3</sub> | 1 |
A-9511 | H | H | H | H | H | O | H | H | 2-OMe,4-CF<sub>3</sub> | 1 |
A-9512 | H | H | H | H | H | O | H | H | 2-OMe,5-CF<sub>3</sub> | 1 |
A-9513 | H | H | H | H | H | O | H | H | 2-OMe,6-CF<sub>3</sub> | 1 |
A-9514 | H | H | H | H | H | O | H | H | 3-OMe,2-CF<sub>3</sub> | 1 |
[表168]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9515 | H | H | H | H | H | O | H | H | 3-OMe,4-CF<sub>3</sub> | 1 |
A-9516 | H | H | H | H | H | O | H | H | 3-OMe,5-CF<sub>3</sub> | 1 |
A-9517 | H | H | H | H | H | O | H | H | 3-OMe,6-CF<sub>3</sub> | 1 |
A-9518 | H | H | H | H | H | O | H | H | 4-OMe,2-CF<sub>3</sub> | 1 |
A-9519 | H | H | H | H | H | O | H | H | 4-OMe,3-CF<sub>3</sub> | 1 |
A-9520 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,3-F | 1 |
A-9521 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,4-F | 1 |
A-9522 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,5-F | 1 |
A-9523 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,6-F | 1 |
A-9524 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,3-Me | 1 |
A-9525 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,4-Me | 1 |
A-9526 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,5-Me | 1 |
A-9527 | H | H | H | H | H | O | H | H | 2-CHF<sub>2</sub>,6-Me | 1 |
A-9528 | H | H | H | H | H | O | H | H | 2-环丙基,3-F | 1 |
A-9529 | H | H | H | H | H | O | H | H | 2-环丙基,4-F | 1 |
A-9530 | H | H | H | H | H | O | H | H | 2-环丙基,5-F | 1 |
A-9531 | H | H | H | H | H | O | H | H | 2-环丙基,6-F | 1 |
A-9532 | H | H | H | H | H | O | H | H | 2-环丙基,3-Me | 1 |
A-9533 | H | H | H | H | H | O | H | H | 2-环丙基,4-Me | 1 |
A-9534 | H | H | H | H | H | O | H | H | 2-环丙基,5-Me | 1 |
A-9535 | H | H | H | H | H | O | H | H | 2-环丙基,6-Me | 1 |
A-9536 | H | H | H | H | H | O | H | H | 2-乙烯基,3-F | 1 |
A-9537 | H | H | H | H | H | O | H | H | 2-乙烯基,4-F | 1 |
A-9538 | H | H | H | H | H | O | H | H | 2-乙烯基,5-F | 1 |
A-9539 | H | H | H | H | H | O | H | H | 2-乙烯基,6-F | 1 |
A-9540 | H | H | H | H | H | O | H | H | 2-乙烯基,3-Me | 1 |
A-9541 | H | H | H | H | H | O | H | H | 2-乙烯基,4-Me | 1 |
A-9542 | H | H | H | H | H | O | H | H | 2-乙烯基,5-Me | 1 |
A-9543 | H | H | H | H | H | O | H | H | 2-乙烯基,6-Me | 1 |
A-9544 | H | H | H | H | H | O | H | H | 2-OEt,3-F | 1 |
A-9545 | H | H | H | H | H | O | H | H | 2-OEt,4-F | 1 |
A-9546 | H | H | H | H | H | O | H | H | 2-OEt,5-F | 1 |
A-9547 | H | H | H | H | H | O | H | H | 2-OEt,6-F | 1 |
A-9548 | H | H | H | H | H | O | H | H | 2-OEt,3-Cl | 1 |
A-9549 | H | H | H | H | H | O | H | H | 2-OEt,4-Cl | 1 |
A-9550 | H | H | H | H | H | O | H | H | 2-OEt,5-Cl | 1 |
A-9551 | H | H | H | H | H | O | H | H | 2-OEt,6-Cl | 1 |
A-9552 | H | H | H | H | H | O | H | H | 2-OEt,3-Me | 1 |
A-9553 | H | H | H | H | H | O | H | H | 2-OEt,4-Me | 1 |
A-9554 | H | H | H | H | H | O | H | H | 2-OEt,5-Me | 1 |
A-9555 | H | H | H | H | H | O | H | H | 2-OEt,6-Me | 1 |
A-9556 | H | H | H | H | H | O | H | H | 2-OPr,3-F | 1 |
A-9557 | H | H | H | H | H | O | H | H | 2-OPr,4-F | 1 |
A-9558 | H | H | H | H | H | O | H | H | 2-OPr,5-F | 1 |
A-9559 | H | H | H | H | H | O | H | H | 2-OPr,6-F | 1 |
A-9560 | H | H | H | H | H | O | H | H | 2-OPr,3-Me | 1 |
A-9561 | H | H | H | H | H | O | H | H | 2-OPr,4-Me | 1 |
A-9562 | H | H | H | H | H | O | H | H | 2-OPr,5-Me | 1 |
A-9563 | H | H | H | H | H | O | H | H | 2-OPr,6-Me | 1 |
A-9564 | H | H | H | H | H | O | H | H | 2-O(i-Pr),3-F | 1 |
A-9565 | H | H | H | H | H | O | H | H | 2-O(i-Pr),4-F | 1 |
A-9566 | H | H | H | H | H | O | H | H | 2-O(i-Pr),5-F | 1 |
A-9567 | H | H | H | H | H | O | H | H | 2-O(i-Pr),6-F | 1 |
A-9568 | H | H | H | H | H | O | H | H | 2-O(i-Pr),3-Me | 1 |
A-9569 | H | H | H | H | H | O | H | H | 2-O(i-Pr),4-Me | 1 |
A-9570 | H | H | H | H | H | O | H | H | 2-O(i-Pr),5-Me | 1 |
A-9571 | H | H | H | H | H | O | H | H | 2-O(i-Pr),6-Me | 1 |
[表169]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9572 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,3-F | 1 |
A-9573 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,4-F | 1 |
A-9574 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,5-F | 1 |
A-9575 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,6-F | 1 |
A-9576 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,3-Me | 1 |
A-9577 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,4-Me | 1 |
A-9578 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,5-Me | 1 |
A-9579 | H | H | H | H | H | O | H | H | 2-OCF<sub>3</sub>,6-Me | 1 |
A-9580 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,3-F | 1 |
A-9581 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,4-F | 1 |
A-9582 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,5-F | 1 |
A-9583 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,6-F | 1 |
A-9584 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,3-Me | 1 |
A-9585 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,4-Me | 1 |
A-9586 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,5-Me | 1 |
A-9587 | H | H | H | H | H | O | H | H | 2-OCHF<sub>2</sub>,6-Me | 1 |
A-9588 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),3-F | 1 |
A-9589 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),4-F | 1 |
A-9590 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),5-F | 1 |
A-9591 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),6-F | 1 |
A-9592 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),3-Me | 1 |
A-9593 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),4-Me | 1 |
A-9594 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),5-Me | 1 |
A-9595 | H | H | H | H | H | O | H | H | 2-(环丙基氧基),6-Me | 1 |
A-9596 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),3-F | 1 |
A-9597 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),4-F | 1 |
A-9598 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),5-F | 1 |
A-9599 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),6-F | 1 |
A-9600 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),3-Me | 1 |
A-9601 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),4-Me | 1 |
A-9602 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),5-Me | 1 |
A-9603 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基),6-Me | 1 |
A-9604 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),3-F | 1 |
A-9605 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),4-F | 1 |
A-9606 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),5-F | 1 |
A-9607 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),6-F | 1 |
A-9608 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),3-Me | 1 |
A-9609 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),4-Me | 1 |
A-9610 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),5-Me | 1 |
A-9611 | H | H | H | H | H | O | H | H | 2-(环氧乙烷-2-基甲基),6-Me | 1 |
A-9612 | H | H | H | H | H | O | H | H | 2-SMe,3-F | 1 |
A-9613 | H | H | H | H | H | O | H | H | 2-SMe,4-F | 1 |
A-9614 | H | H | H | H | H | O | H | H | 2-SMe,5-F | 1 |
A-9615 | H | H | H | H | H | O | H | H | 2-SMe,6-F | 1 |
A-9616 | H | H | H | H | H | O | H | H | 2-SMe,3-Me | 1 |
A-9617 | H | H | H | H | H | O | H | H | 2-SMe,4-Me | 1 |
A-9618 | H | H | H | H | H | O | H | H | 2-SMe,5-Me | 1 |
A-9619 | H | H | H | H | H | O | H | H | 2-SMe,6-Me | 1 |
A-9620 | H | H | H | H | H | O | H | H | 2-SEt,3-F | 1 |
A-9621 | H | H | H | H | H | O | H | H | 2-SEt,4-F | 1 |
A-9622 | H | H | H | H | H | O | H | H | 2-SEt,5-F | 1 |
A-9623 | H | H | H | H | H | O | H | H | 2-SEt,6-F | 1 |
A-9624 | H | H | H | H | H | O | H | H | 2-SEt,3-Me | 1 |
A-9625 | H | H | H | H | H | O | H | H | 2-SEt,4-Me | 1 |
A-9626 | H | H | H | H | H | O | H | H | 2-SEt,5-Me | 1 |
A-9627 | H | H | H | H | H | O | H | H | 2-SEt,6-Me | 1 |
A-9628 | H | H | H | H | H | O | H | H | 2-S(=O)Me,3-F | 1 |
[表170]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9629 | H | H | H | H | H | O | H | H | 2-S(=O)Me,4-F | 1 |
A-9630 | H | H | H | H | H | O | H | H | 2-S(=O)Me,5-F | 1 |
A-9631 | H | H | H | H | H | O | H | H | 2-S(=O)Me,6-F | 1 |
A-9632 | H | H | H | H | H | O | H | H | 3-S(=O)Me,2-F | 1 |
A-9633 | H | H | H | H | H | O | H | H | 3-S(=O)Me,4-F | 1 |
A-9634 | H | H | H | H | H | O | H | H | 3-S(=O)Me,5-F | 1 |
A-9635 | H | H | H | H | H | O | H | H | 3-S(=O)Me,6-F | 1 |
A-9636 | H | H | H | H | H | O | H | H | 2-S(=O)Me,3-Me | 1 |
A-9637 | H | H | H | H | H | O | H | H | 2-S(=O)Me,4-Me | 1 |
A-9638 | H | H | H | H | H | O | H | H | 2-S(=O)Me,5-Me | 1 |
A-9639 | H | H | H | H | H | O | H | H | 2-S(=O)Me,6-Me | 1 |
A-9640 | H | H | H | H | H | O | H | H | 3-S(=O)Me,2-Me | 1 |
A-9641 | H | H | H | H | H | O | H | H | 3-S(=O)Me,4-Me | 1 |
A-9642 | H | H | H | H | H | O | H | H | 3-S(=O)Me,5-Me | 1 |
A-9643 | H | H | H | H | H | O | H | H | 3-S(=O)Me,6-Me | 1 |
A-9644 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,3-F | 1 |
A-9645 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,4-F | 1 |
A-9646 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,5-F | 1 |
A-9647 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,6-F | 1 |
A-9648 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,3-Me | 1 |
A-9649 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,4-Me | 1 |
A-9650 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,5-Me | 1 |
A-9651 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>Me,6-Me | 1 |
A-9652 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,3-F | 1 |
A-9653 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,4-F | 1 |
A-9654 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,5-F | 1 |
A-9655 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,6-F | 1 |
A-9656 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,3-Me | 1 |
A-9657 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,4-Me | 1 |
A-9658 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,5-Me | 1 |
A-9659 | H | H | H | H | H | O | H | H | 2-SCF<sub>3</sub>,6-Me | 1 |
A-9660 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,3-F | 1 |
A-9661 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,4-F | 1 |
A-9662 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,5-F | 1 |
A-9663 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,6-F | 1 |
A-9664 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,3-Me | 1 |
A-9665 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,4-Me | 1 |
A-9666 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,5-Me | 1 |
A-9667 | H | H | H | H | H | O | H | H | 2-S(=O)CF<sub>3</sub>,6-Me | 1 |
A-9668 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-F | 1 |
A-9669 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-F | 1 |
A-9670 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 1 |
A-9671 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 1 |
A-9672 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-Me | 1 |
A-9673 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-Me | 1 |
A-9674 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 1 |
A-9675 | H | H | H | H | H | O | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 1 |
A-9676 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),3-F | 1 |
A-9677 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),4-F | 1 |
A-9678 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),5-F | 1 |
A-9679 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),6-F | 1 |
A-9680 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),3-Me | 1 |
A-9681 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),4-Me | 1 |
A-9682 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),5-Me | 1 |
A-9683 | H | H | H | H | H | O | H | H | 2-(环丙基硫基),6-Me | 1 |
A-9684 | H | H | H | H | H | O | H | H | 2-C(=O)Me,3-F | 1 |
A-9685 | H | H | H | H | H | O | H | H | 2-C(=O)Me,4-F | 1 |
[表171]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9686 | H | H | H | H | H | O | H | H | 2-C(=O)Me,5-F | 1 |
A-9687 | H | H | H | H | H | O | H | H | 2-C(=O)Me,6-F | 1 |
A-9688 | H | H | H | H | H | O | H | H | 2-C(=O)Me,3-Me | 1 |
A-9689 | H | H | H | H | H | O | H | H | 2-C(=O)Me,4-Me | 1 |
A-9690 | H | H | H | H | H | O | H | H | 2-C(=O)Me,5-Me | 1 |
A-9691 | H | H | H | H | H | O | H | H | 2-C(=O)Me,6-Me | 1 |
A-9692 | H | H | H | H | H | O | H | H | 3-C(=O)Me,2-F | 1 |
A-9693 | H | H | H | H | H | O | H | H | 3-C(=O)Me,4-F | 1 |
A-9694 | H | H | H | H | H | O | H | H | 3-C(=O)Me,5-F | 1 |
A-9695 | H | H | H | H | H | O | H | H | 3-C(=O)Me,6-F | 1 |
A-9696 | H | H | H | H | H | O | H | H | 3-C(=O)Me,2-Me | 1 |
A-9697 | H | H | H | H | H | O | H | H | 3-C(=O)Me,4-Me | 1 |
A-9698 | H | H | H | H | H | O | H | H | 3-C(=O)Me,5-Me | 1 |
A-9699 | H | H | H | H | H | O | H | H | 3-C(=O)Me,6-Me | 1 |
A-9700 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,3-F | 1 |
A-9701 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,4-F | 1 |
A-9702 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,5-F | 1 |
A-9703 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,6-F | 1 |
A-9704 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,3-Me | 1 |
A-9705 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,4-Me | 1 |
A-9706 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,5-Me | 1 |
A-9707 | H | H | H | H | H | O | H | H | 2-C(=O)OMe,6-Me | 1 |
A-9708 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,3-F | 1 |
A-9709 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,4-F | 1 |
A-9710 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,5-F | 1 |
A-9711 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,6-F | 1 |
A-9712 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,3-Me | 1 |
A-9713 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,4-Me | 1 |
A-9714 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,5-Me | 1 |
A-9715 | H | H | H | H | H | O | H | H | 2-C(=O)OEt,6-Me | 1 |
A-9716 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,3-F | 1 |
A-9717 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,4-F | 1 |
A-9718 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,5-F | 1 |
A-9719 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,6-F | 1 |
A-9720 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,3-Me | 1 |
A-9721 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,4-Me | 1 |
A-9722 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,5-Me | 1 |
A-9723 | H | H | H | H | H | O | H | H | 2-C(=O)NH<sub>2</sub>,6-Me | 1 |
A-9724 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,3-F | 1 |
A-9725 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,4-F | 1 |
A-9726 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,5-F | 1 |
A-9727 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,6-F | 1 |
A-9728 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,3-Me | 1 |
A-9729 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,4-Me | 1 |
A-9730 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,5-Me | 1 |
A-9731 | H | H | H | H | H | O | H | H | 2-C(=O)NHMe,6-Me | 1 |
A-9732 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,3-F | 1 |
A-9733 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,4-F | 1 |
A-9734 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,5-F | 1 |
A-9735 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,6-F | 1 |
A-9736 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,3-Me | 1 |
A-9737 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,4-Me | 1 |
A-9738 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,5-Me | 1 |
A-9739 | H | H | H | H | H | O | H | H | 2-C(=O)NMe<sub>2</sub>,6-Me | 1 |
A-9740 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,3-F | 1 |
A-9741 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,4-F | 1 |
A-9742 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,5-F | 1 |
[表172]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9743 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,6-F | 1 |
A-9744 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,3-Me | 1 |
A-9745 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,4-Me | 1 |
A-9746 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,5-Me | 1 |
A-9747 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OH,6-Me | 1 |
A-9748 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-F | 1 |
A-9749 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 1 |
A-9750 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 1 |
A-9751 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 1 |
A-9752 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-Me | 1 |
A-9753 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 1 |
A-9754 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 1 |
A-9755 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 1 |
A-9756 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-F | 1 |
A-9757 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-F | 1 |
A-9758 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-F | 1 |
A-9759 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-F | 1 |
A-9760 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-Me | 1 |
A-9761 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-Me | 1 |
A-9762 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-Me | 1 |
A-9763 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Me | 1 |
A-9764 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,3-F | 1 |
A-9765 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,4-F | 1 |
A-9766 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,5-F | 1 |
A-9767 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,6-F | 1 |
A-9768 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,3-Me | 1 |
A-9769 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,4-Me | 1 |
A-9770 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 1 |
A-9771 | H | H | H | H | H | O | H | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 1 |
A-9772 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-F | 1 |
A-9773 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-F | 1 |
A-9774 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 1 |
A-9775 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 1 |
A-9776 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-Me | 1 |
A-9777 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-Me | 1 |
A-9778 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 1 |
A-9779 | H | H | H | H | H | O | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 1 |
A-9780 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-F | 1 |
A-9781 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-F | 1 |
A-9782 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 1 |
A-9783 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 1 |
A-9784 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-Me | 1 |
A-9785 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-Me | 1 |
A-9786 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 1 |
A-9787 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 1 |
A-9788 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-F | 1 |
A-9789 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-F | 1 |
A-9790 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-F | 1 |
A-9791 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-F | 1 |
A-9792 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-Me | 1 |
A-9793 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-Me | 1 |
A-9794 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-Me | 1 |
A-9795 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-Me | 1 |
A-9796 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),3-F | 1 |
A-9797 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),4-F | 1 |
A-9798 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),5-F | 1 |
A-9799 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),6-F | 1 |
[表173]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9800 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),3-Me | 1 |
A-9801 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),4-Me | 1 |
A-9802 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),5-Me | 1 |
A-9803 | H | H | H | H | H | O | H | H | 2-(苯甲基氧基),6-Me | 1 |
A-9804 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,3-F | 1 |
A-9805 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,4-F | 1 |
A-9806 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,5-F | 1 |
A-9807 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,6-F | 1 |
A-9808 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,3-Me | 1 |
A-9809 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,4-Me | 1 |
A-9810 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,5-Me | 1 |
A-9811 | H | H | H | H | H | O | H | H | 2-NH<sub>2</sub>,6-Me | 1 |
A-9812 | H | H | H | H | H | O | H | H | 2-NHMe,3-F | 1 |
A-9813 | H | H | H | H | H | O | H | H | 2-NHMe,4-F | 1 |
A-9814 | H | H | H | H | H | O | H | H | 2-NHMe,5-F | 1 |
A-9815 | H | H | H | H | H | O | H | H | 2-NHMe,6-F | 1 |
A-9816 | H | H | H | H | H | O | H | H | 2-NHMe,3-Me | 1 |
A-9817 | H | H | H | H | H | O | H | H | 2-NHMe,4-Me | 1 |
A-9818 | H | H | H | H | H | O | H | H | 2-NHMe,5-Me | 1 |
A-9819 | H | H | H | H | H | O | H | H | 2-NHMe,6-Me | 1 |
A-9820 | H | H | H | H | H | O | H | H | 2-NHEt,3-F | 1 |
A-9821 | H | H | H | H | H | O | H | H | 2-NHEt,4-F | 1 |
A-9822 | H | H | H | H | H | O | H | H | 2-NHEt,5-F | 1 |
A-9823 | H | H | H | H | H | O | H | H | 2-NHEt,6-F | 1 |
A-9824 | H | H | H | H | H | O | H | H | 2-NHEt,3-Me | 1 |
A-9825 | H | H | H | H | H | O | H | H | 2-NHEt,4-Me | 1 |
A-9826 | H | H | H | H | H | O | H | H | 2-NHEt,5-Me | 1 |
A-9827 | H | H | H | H | H | O | H | H | 2-NHEt,6-Me | 1 |
A-9828 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,3-F | 1 |
A-9829 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,4-F | 1 |
A-9830 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,5-F | 1 |
A-9831 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,6-F | 1 |
A-9832 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,3-Me | 1 |
A-9833 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,4-Me | 1 |
A-9834 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,5-Me | 1 |
A-9835 | H | H | H | H | H | O | H | H | 2-NMe<sub>2</sub>,6-Me | 1 |
A-9836 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,3-F | 1 |
A-9837 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,4-F | 1 |
A-9838 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,5-F | 1 |
A-9839 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,6-F | 1 |
A-9840 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,3-Me | 1 |
A-9841 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,4-Me | 1 |
A-9842 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,5-Me | 1 |
A-9843 | H | H | H | H | H | O | H | H | 2-NEt<sub>2</sub>,6-Me | 1 |
A-9844 | H | H | H | H | H | O | H | H | 2-CHO,3-F | 1 |
A-9845 | H | H | H | H | H | O | H | H | 2-CHO,4-F | 1 |
A-9846 | H | H | H | H | H | O | H | H | 2-CHO,5-F | 1 |
A-9847 | H | H | H | H | H | O | H | H | 2-CHO,6-F | 1 |
A-9848 | H | H | H | H | H | O | H | H | 2-CHO,3-Me | 1 |
A-9849 | H | H | H | H | H | O | H | H | 2-CHO,4-Me | 1 |
A-9850 | H | H | H | H | H | O | H | H | 2-CHO,5-Me | 1 |
A-9851 | H | H | H | H | H | O | H | H | 2-CHO,6-Me | 1 |
A-9852 | H | H | H | H | H | O | H | H | 2-C(=O)OH,3-F | 1 |
A-9853 | H | H | H | H | H | O | H | H | 2-C(=O)OH,4-F | 1 |
A-9854 | H | H | H | H | H | O | H | H | 2-C(=O)OH,5-F | 1 |
A-9855 | H | H | H | H | H | O | H | H | 2-C(=O)OH,6-F | 1 |
A-9856 | H | H | H | H | H | O | H | H | 2-C(=O)OH,3-Me | 1 |
[表174]
[表175]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9914 | H | H | H | H | H | O | H | H | 2-CN,5-Cl | 1 |
A-9915 | H | H | H | H | H | O | H | H | 2-CN,6-Cl | 1 |
A-9916 | H | H | H | H | H | O | H | H | 2-CN,3-Me | 1 |
A-9917 | H | H | H | H | H | O | H | H | 2-CN,4-Me | 1 |
A-9918 | H | H | H | H | H | O | H | H | 2-CN,5-Me | 1 |
A-9919 | H | H | H | H | H | O | H | H | 2-CN,6-Me | 1 |
A-9920 | H | H | H | H | H | O | H | H | 2-CN,3-OMe | 1 |
A-9921 | H | H | H | H | H | O | H | H | 2-CN,4-OMe | 1 |
A-9922 | H | H | H | H | H | O | H | H | 2-CN,5-OMe | 1 |
A-9923 | H | H | H | H | H | O | H | H | 2-CN,6-OMe | 1 |
A-9924 | H | H | H | H | H | O | H | H | 3-CN,2-F | 1 |
A-9925 | H | H | H | H | H | O | H | H | 3-CN,4-F | 1 |
A-9926 | H | H | H | H | H | O | H | H | 3-CN,5-F | 1 |
A-9927 | H | H | H | H | H | O | H | H | 3-CN,6-F | 1 |
A-9928 | H | H | H | H | H | O | H | H | 3-CN,2-Cl | 1 |
A-9929 | H | H | H | H | H | O | H | H | 3-CN,4-Cl | 1 |
A-9930 | H | H | H | H | H | O | H | H | 3-CN,5-Cl | 1 |
A-9931 | H | H | H | H | H | O | H | H | 3-CN,6-Cl | 1 |
A-9932 | H | H | H | H | H | O | H | H | 3-CN,2-Me | 1 |
A-9933 | H | H | H | H | H | O | H | H | 3-CN,4-Me | 1 |
A-9934 | H | H | H | H | H | O | H | H | 3-CN,5-Me | 1 |
A-9935 | H | H | H | H | H | O | H | H | 3-CN,6-Me | 1 |
A-9936 | H | H | H | H | H | O | H | H | 3-CN,2-OMe | 1 |
A-9937 | H | H | H | H | H | O | H | H | 3-CN,4-OMe | 1 |
A-9938 | H | H | H | H | H | O | H | H | 3-CN,5-OMe | 1 |
A-9939 | H | H | H | H | H | O | H | H | 3-CN,6-OMe | 1 |
A-9940 | H | H | H | H | H | O | H | H | 4-CN,2-F | 1 |
A-9941 | H | H | H | H | H | O | H | H | 4-CN,3-F | 1 |
A-9942 | H | H | H | H | H | O | H | H | 4-CN,2-Cl | 1 |
A-9943 | H | H | H | H | H | O | H | H | 4-CN,3-Cl | 1 |
A-9944 | H | H | H | H | H | O | H | H | 4-CN,2-Me | 1 |
A-9945 | H | H | H | H | H | O | H | H | 4-CN,3-Me | 1 |
A-9946 | H | H | H | H | H | O | H | H | 4-CN,2-OMe | 1 |
A-9947 | H | H | H | H | H | O | H | H | 4-CN,3-OMe | 1 |
A-9948 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,3-F | 1 |
A-9949 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,4-F | 1 |
A-9950 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,5-F | 1 |
A-9951 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,6-F | 1 |
A-9952 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,3-Me | 1 |
A-9953 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,4-Me | 1 |
A-9954 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,5-Me | 1 |
A-9955 | H | H | H | H | H | O | H | H | 2-NO<sub>2</sub>,6-Me | 1 |
A-9956 | H | H | H | H | H | O | H | H | 2-Me,3,4-F<sub>2</sub> | 1 |
A-9957 | H | H | H | H | H | O | H | H | 2-Me,3,5-F<sub>2</sub> | 1 |
A-9958 | H | H | H | H | H | O | H | H | 2-Me,3,6-F<sub>2</sub> | 1 |
A-9959 | H | H | H | H | H | O | H | H | 2-Me,4,5-F<sub>2</sub> | 1 |
A-9960 | H | H | H | H | H | O | H | H | 2-OMe,3,4-F<sub>2</sub> | 1 |
A-9961 | H | H | H | H | H | O | H | H | 2-OMe,3,5-F<sub>2</sub> | 1 |
A-9962 | H | H | H | H | H | O | H | H | 2-OMe,3,6-F<sub>2</sub> | 1 |
A-9963 | H | H | H | H | H | O | H | H | 2-OMe,4,5-F<sub>2</sub> | 1 |
A-9964 | H | H | H | H | H | O | H | H | 2-(CH<sub>2</sub>)<sub>3</sub>-3 | 1 |
A-9965 | H | H | H | H | H | O | H | H | 2-(CH<sub>2</sub>)<sub>4</sub>-3 | 1 |
A-9966 | H | H | H | H | H | O | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>)-3 | 1 |
A-9967 | H | H | H | H | H | O | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-3 | 1 |
A-9968 | H | H | H | H | H | O | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>O)-3 | 1 |
A-9969 | H | H | H | H | H | O | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-3 | 1 |
A-9970 | H | H | H | H | H | O | H | H | 3-(CH<sub>2</sub>)<sub>3</sub>-4 | 1 |
[表176]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-9971 | H | H | H | H | H | O | H | H | 3-(CH<sub>2</sub>)<sub>4</sub>-4 | 1 |
A-9972 | H | H | H | H | H | O | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>)-4 | 1 |
A-9973 | H | H | H | H | H | O | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-4 | 1 |
A-9974 | H | H | H | H | H | O | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>O)-4 | 1 |
A-9975 | H | H | H | H | H | O | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-4 | 1 |
A-9976 | H | H | H | H | H | O | H | H | 2-(OCH<sub>2</sub>O)-3 | 1 |
A-9977 | H | H | H | H | H | O | H | H | 3-(OCH<sub>2</sub>O)-4 | 1 |
A-9978 | H | H | H | H | H | O | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>O)-3 | 1 |
A-9979 | H | H | H | H | H | O | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>O)-4 | 1 |
A-9980 | H | H | H | H | H | O | H | H | 2-(OCF<sub>2</sub>O)-3 | 1 |
A-9981 | H | H | H | H | H | O | H | H | 3-(OCF<sub>2</sub>O)-4 | 1 |
A-9982 | H | H | H | H | H | O | H | H | 2-Me,6-Et | 1 |
A-9983 | H | H | H | H | H | O | H | H | 2-Me,4,5-F<sub>2</sub> | 1 |
A-9984 | H | H | H | H | H | O | H | H | 2-环丙基,6-OMe | 1 |
A-9985 | H | H | H | H | H | O | H | H | 2-Me,5-Et | 1 |
A-9986 | H | H | H | H | H | O | H | H | 2,6-Et<sub>2</sub> | 1 |
A-9987 | H | H | H | H | H | O | H | H | 2-Et,6-F | 1 |
A-9988 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 1 |
A-9989 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 1 |
A-9990 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 1 |
A-9991 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-OMe | 0 |
A-9992 | H | H | H | H | H | O | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-OMe | 1 |
A-9993 | H | H | H | H | H | O | 吡啶-2-基甲基 | H | 2-Me | 0 |
A-9994 | H | H | H | H | H | O | 吡啶-3-基甲基 | H | 2-Me | 0 |
A-9995 | H | H | H | H | H | O | H | H | 2-CH2OCH3,5-OMe | 0 |
A-9996 | H | H | H | H | H | O | H | H | 2-CH2OCH3,6-CN | 0 |
A-9997 | H | H | H | H | H | O | H | H | 2-OEt,6-CN | 0 |
A-9998 | H | H | H | H | H | O | H | H | 2-OEt,6-OMe | 0 |
A-9999 | H | H | H | H | H | O | H | H | 2,6-OEt2 | 0 |
A-10000 | H | H | H | H | H | O | Me | H | 3-CF3 | 0 |
A-10001 | H | H | H | H | Me | O | H | H | 2-F | 0 |
A-10002 | H | H | H | H | H | O | H | H | 2-CN,6-环丙基 | 0 |
A-10003 | H | H | H | H | H | O | H | H | 2-MeO,3-Me,6-MeO | 0 |
A-10004 | H | H | H | H | H | O | H | H | 2-MeO,4-Me,6-MeO | 0 |
A-10005 | H | H | H | H | H | O | H | H | 2-MeO,3-F,6-MeO | 0 |
A-10006 | H | H | H | H | H | O | H | H | 2-MeO,4-F,6-MeO | 0 |
A-10007 | H | H | H | H | H | O | H | H | 2-Et,6-OEt | 0 |
A-10008 | H | H | H | H | H | O | H | H | 2-环丙基,6-OEt | 0 |
A-10009 | H | H | H | H | H | O | H | H | 2,6-SMe2 | 0 |
A-10010 | H | H | H | H | H | O | H | H | 2-NO2,6-OMe | 0 |
A-10011 | H | H | H | H | H | O | H | H | 2-NO2,6-CN | 0 |
A-10012 | H | H | H | H | H | O | H | H | 2-Cl,6-NO2 | 0 |
A-10013 | H | H | H | H | H | O | H | H | 2-Cl,6-SMe | 0 |
A-10014 | H | H | H | H | H | O | H | H | 2-Cl,6-Et | 0 |
A-10015 | H | H | H | H | H | O | H | H | 2-CN,6-SMe | 0 |
A-10016 | H | H | H | H | H | O | H | H | 2,6-CN2 | 0 |
A-10017 | H | H | H | H | H | O | H | H | 2-OMe,6-OCF3 | 0 |
A-10018 | H | H | H | H | H | O | H | H | 2-CH2SCH3,6-OMe | 0 |
A-10019 | H | H | H | H | H | O | H | H | 2-OCHF2,6-OMe | 0 |
A-10020 | H | H | H | H | H | O | H | H | 2-Cl,6-CH2SCH3 | 0 |
A-10021 | H | H | H | H | H | O | H | H | 2-CN,6-Et | 0 |
A-10022 | H | H | H | H | H | O | H | H | 2-Et,6-OMe | 0 |
A-10024 | H | H | H | H | H | O | H | H | 2-(吡啶-2-基) | 0 |
A-10025 | H | H | H | H | H | O | H | H | 3-(吡啶-2-基) | 0 |
A-10026 | H | H | H | H | H | O | H | H | 4-(吡啶-2-基) | 0 |
A-10027 | H | H | H | H | H | O | H | H | 2-(嘧啶-2-基) | 0 |
A-10028 | H | H | H | H | H | O | H | H | 3-(嘧啶-2-基) | 0 |
[表177]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
A-10029 | H | H | H | H | H | O | H | H | 4-(嘧啶-2-基) | 0 |
A-10030 | H | H | H | H | H | O | H | H | 2-(吡嗪-2-基) | 0 |
A-10031 | H | H | H | H | H | O | H | H | 3-(吡嗪-2-基) | 0 |
A-10032 | H | H | H | H | H | O | H | H | 4-(吡嗪-2-基) | 0 |
A-10033 | H | H | H | H | H | O | H | H | 2-(1,3,5-三嗪-2-基) | 0 |
A-10034 | H | H | H | H | H | O | H | H | 3-(1,3,5-三嗪-2-基) | 0 |
A-10035 | H | H | H | H | H | O | H | H | 4-(1,3,5-三嗪-2-基) | 0 |
A-10036 | H | H | H | H | H | O | H | H | 2-(1,2,4-三嗪-3-基) | 0 |
A-10037 | H | H | H | H | H | O | H | H | 3-(1,2,4-三嗪-3-基) | 0 |
A-10038 | H | H | H | H | H | O | H | H | 4-(1,2,4-三嗪-3-基) | 0 |
A-10039 | H | H | H | H | H | O | H | H | 2-(1,2,4-三嗪-6-基) | 0 |
A-10040 | H | H | H | H | H | O | H | H | 3-(1,2,4-三嗪-6-基) | 0 |
A-10041 | H | H | H | H | H | O | H | H | 4-(1,2,4-三嗪-6-基) | 0 |
A-10042 | H | H | H | H | H | O | H | H | 2-(1H-吡唑-1-基) | 0 |
A-10043 | H | H | H | H | H | O | H | H | 3-(1H-吡唑-1-基) | 0 |
A-10044 | H | H | H | H | H | O | H | H | 4-(1H-吡唑-1-基) | 0 |
[表178]
[表179]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-0053 | H | H | H | H | H | O | H | H | 3-F-6-OMe-吡啶-2-基 | 0 |
B-0054 | H | H | H | H | H | O | H | H | 3-Cl-4-F-吡啶-2-基 | 0 |
B-0055 | H | H | H | H | H | O | H | H | 3-Cl-5-F-吡啶-2-基 | 0 |
B-0056 | H | H | H | H | H | O | H | H | 3-Cl-6-F-吡啶-2-基 | 0 |
B-0057 | H | H | H | H | H | O | H | H | 3-Cl-4-Me-吡啶-2-基 | 0 |
B-0058 | H | H | H | H | H | O | H | H | 3-Cl-5-Me-吡啶-2-基 | 0 |
B-0059 | H | H | H | H | H | O | H | H | 3-Cl-6-Me-吡啶-2-基 | 0 |
B-0060 | H | H | H | H | H | O | H | H | 3-Me-4-F-吡啶-2-基 | 0 |
B-0061 | H | H | H | H | H | O | H | H | 3-Me-5-F-吡啶-2-基 | 0 |
B-0062 | H | H | H | H | H | O | H | H | 3-Me-6-F-吡啶-2-基 | 0 |
B-0063 | H | H | H | H | H | O | H | H | 3-Me-4-Cl-吡啶-2-基 | 0 |
B-0064 | H | H | H | H | H | O | H | H | 3-Me-5-Cl-吡啶-2-基 | 0 |
B-0065 | H | H | H | H | H | O | H | H | 3-Me-6-Cl-吡啶-2-基 | 0 |
B-0066 | H | H | H | H | H | O | H | H | 3,4-(Me)2-吡啶-2-基 | 0 |
B-0067 | H | H | H | H | H | O | H | H | 3,5-(Me)2-吡啶-2-基 | 0 |
B-0068 | H | H | H | H | H | O | H | H | 3,6-(Me)2-吡啶-2-基 | 0 |
B-0069 | H | H | H | H | H | O | H | H | 3-Me-4-OMe-吡啶-2-基 | 0 |
B-0070 | H | H | H | H | H | O | H | H | 3-Me-5-OMe-吡啶-2-基 | 0 |
B-0071 | H | H | H | H | H | O | H | H | 3-Me-6-OMe-吡啶-2-基 | 0 |
B-0072 | H | H | H | H | H | O | H | H | 3-CF3-4-F-吡啶-2-基 | 0 |
B-0073 | H | H | H | H | H | O | H | H | 3-CF3-5-F-吡啶-2-基 | 0 |
B-0074 | H | H | H | H | H | O | H | H | 3-CF3-6-F-吡啶-2-基 | 0 |
B-0075 | H | H | H | H | H | O | H | H | 3-CF3-4-Me-吡啶-2-基 | 0 |
B-0076 | H | H | H | H | H | O | H | H | 3-CF3-5-Me-吡啶-2-基 | 0 |
B-0077 | H | H | H | H | H | O | H | H | 3-CF3-6-Me-吡啶-2-基 | 0 |
B-0078 | H | H | H | H | H | O | H | H | 3-OMe-4-F-吡啶-2-基 | 0 |
B-0079 | H | H | H | H | H | O | H | H | 3-OMe-5-F-吡啶-2-基 | 0 |
B-0080 | H | H | H | H | H | O | H | H | 3-OMe-6-F-吡啶-2-基 | 0 |
B-0081 | H | H | H | H | H | O | H | H | 3-OMe-4-Cl-吡啶-2-基 | 0 |
B-0082 | H | H | H | H | H | O | H | H | 3-OMe-5-Cl-吡啶-2-基 | 0 |
B-0083 | H | H | H | H | H | O | H | H | 3-OMe-6-Cl-吡啶-2-基 | 0 |
B-0084 | H | H | H | H | H | O | H | H | 3-OMe-4-Me-吡啶-2-基 | 0 |
B-0085 | H | H | H | H | H | O | H | H | 3-OMe-5-Me-吡啶-2-基 | 0 |
B-0086 | H | H | H | H | H | O | H | H | 3-OMe-6-Me-吡啶-2-基 | 0 |
B-0087 | H | H | H | H | H | O | H | H | 3,4-(OMe)2-吡啶-2-基 | 0 |
B-0088 | H | H | H | H | H | O | H | H | 3,5-(OMe)2-吡啶-2-基 | 0 |
B-0089 | H | H | H | H | H | O | H | H | 3,6-(OMe)2-吡啶-2-基 | 0 |
B-0090 | H | H | H | H | H | O | H | H | 吡啶-3-基 | 0 |
B-0091 | H | H | H | H | H | O | H | H | 2-F-吡啶-3-基 | 0 |
B-0092 | H | H | H | H | H | O | H | H | 4-F-吡啶-3-基 | 0 |
B-0093 | H | H | H | H | H | O | H | H | 5-F-吡啶-3-基 | 0 |
B-0094 | H | H | H | H | H | O | H | H | 6-F-吡啶-3-基 | 0 |
B-0095 | H | H | H | H | H | O | H | H | 2-Cl-吡啶-3-基 | 0 |
B-0096 | H | H | H | H | H | O | H | H | 4-Cl-吡啶-3-基 | 0 |
B-0097 | H | H | H | H | H | O | H | H | 5-Cl-吡啶-3-基 | 0 |
B-0098 | H | H | H | H | H | O | H | H | 6-Cl-吡啶-3-基 | 0 |
B-0099 | H | H | H | H | H | O | H | H | 2-Me-吡啶-3-基 | 0 |
B-0100 | H | H | H | H | H | O | H | H | 4-Me-吡啶-3-基 | 0 |
B-0101 | H | H | H | H | H | O | H | H | 5-Me-吡啶-3-基 | 0 |
B-0102 | H | H | H | H | H | O | H | H | 6-Me-吡啶-3-基 | 0 |
B-0103 | H | H | H | H | H | O | H | H | 2-CF3-吡啶-3-基 | 0 |
B-0104 | H | H | H | H | H | O | H | H | 4-CF3-吡啶-3-基 | 0 |
B-0105 | H | H | H | H | H | O | H | H | 5-CF3-吡啶-3-基 | 0 |
B-0106 | H | H | H | H | H | O | H | H | 6-CF3-吡啶-3-基 | 0 |
B-0107 | H | H | H | H | H | O | H | H | 2-OMe-吡啶-3-基 | 0 |
B-0108 | H | H | H | H | H | O | H | H | 4-OMe-吡啶-3-基 | 0 |
B-0109 | H | H | H | H | H | O | H | H | 5-OMe-吡啶-3-基 | 0 |
[表180]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-0110 | H | H | H | H | H | O | H | H | 6-OMe-吡啶-3-基 | 0 |
B-0111 | H | H | H | H | H | O | H | H | 2,4-F2-吡啶-3-基 | 0 |
B-0112 | H | H | H | H | H | O | H | H | 2,5-F2-吡啶-3-基 | 0 |
B-0113 | H | H | H | H | H | O | H | H | 2,6-F2-吡啶-3-基 | 0 |
B-0114 | H | H | H | H | H | O | H | H | 4,5-F2-吡啶-3-基 | 0 |
B-0115 | H | H | H | H | H | O | H | H | 4,6-F2-吡啶-3-基 | 0 |
B-0116 | H | H | H | H | H | O | H | H | 2,4-Cl2-吡啶-3-基 | 0 |
B-0117 | H | H | H | H | H | O | H | H | 2,5-Cl2-吡啶-3-基 | 0 |
B-0118 | H | H | H | H | H | O | H | H | 2,6-Cl2-吡啶-3-基 | 0 |
B-0119 | H | H | H | H | H | O | H | H | 4,5-Cl2-吡啶-3-基 | 0 |
B-0120 | H | H | H | H | H | O | H | H | 4,6-Cl2-吡啶-3-基 | 0 |
B-0121 | H | H | H | H | H | O | H | H | 2-F-4-Cl-吡啶-3-基 | 0 |
B-0122 | H | H | H | H | H | O | H | H | 2-F-5-Cl-吡啶-3-基 | 0 |
B-0123 | H | H | H | H | H | O | H | H | 2-F-6-Cl-吡啶-3-基 | 0 |
B-0124 | H | H | H | H | H | O | H | H | 4-F-2-Cl-吡啶-3-基 | 0 |
B-0125 | H | H | H | H | H | O | H | H | 4-F-5-Cl-吡啶-3-基 | 0 |
B-0126 | H | H | H | H | H | O | H | H | 4-F-6-Cl-吡啶-3-基 | 0 |
B-0127 | H | H | H | H | H | O | H | H | 2-F-4-Me-吡啶-3-基 | 0 |
B-0128 | H | H | H | H | H | O | H | H | 2-F-5-Me-吡啶-3-基 | 0 |
B-0129 | H | H | H | H | H | O | H | H | 2-F-6-Me-吡啶-3-基 | 0 |
B-0130 | H | H | H | H | H | O | H | H | 4-F-2-Me-吡啶-3-基 | 0 |
B-0131 | H | H | H | H | H | O | H | H | 4-F-5-Me-吡啶-3-基 | 0 |
B-0132 | H | H | H | H | H | O | H | H | 4-F-6-Me-吡啶-3-基 | 0 |
B-0133 | H | H | H | H | H | O | H | H | 2-F-4-OMe-吡啶-3-基 | 0 |
B-0134 | H | H | H | H | H | O | H | H | 2-F-5-OMe-吡啶-3-基 | 0 |
B-0135 | H | H | H | H | H | O | H | H | 2-F-6-OMe-吡啶-3-基 | 0 |
B-0136 | H | H | H | H | H | O | H | H | 4-F-2-OMe-吡啶-3-基 | 0 |
B-0137 | H | H | H | H | H | O | H | H | 4-F-5-OMe-吡啶-3-基 | 0 |
B-0138 | H | H | H | H | H | O | H | H | 4-F-6-OMe-吡啶-3-基 | 0 |
B-0139 | H | H | H | H | H | O | H | H | 2-Cl-5-F-吡啶-3-基 | 0 |
B-0140 | H | H | H | H | H | O | H | H | 2-Cl-6-F-吡啶-3-基 | 0 |
B-0141 | H | H | H | H | H | O | H | H | 4-Cl-5-F-吡啶-3-基 | 0 |
B-0142 | H | H | H | H | H | O | H | H | 4-Cl-6-F-吡啶-3-基 | 0 |
B-0143 | H | H | H | H | H | O | H | H | 2-Cl-4-Me-吡啶-3-基 | 0 |
B-0144 | H | H | H | H | H | O | H | H | 2-Cl-5-Me-吡啶-3-基 | 0 |
B-0145 | H | H | H | H | H | O | H | H | 2-Cl-6-Me-吡啶-3-基 | 0 |
B-0146 | H | H | H | H | H | O | H | H | 4-Cl-2-Me-吡啶-3-基 | 0 |
B-0147 | H | H | H | H | H | O | H | H | 4-Cl-5-Me-吡啶-3-基 | 0 |
B-0148 | H | H | H | H | H | O | H | H | 4-Cl-6-Me-吡啶-3-基 | 0 |
B-0149 | H | H | H | H | H | O | H | H | 2-Me-5-F-吡啶-3-基 | 0 |
B-0150 | H | H | H | H | H | O | H | H | 2-Me-6-F-吡啶-3-基 | 0 |
B-0151 | H | H | H | H | H | O | H | H | 4-Me-5-F-吡啶-3-基 | 0 |
B-0152 | H | H | H | H | H | O | H | H | 4-Me-6-F-吡啶-3-基 | 0 |
B-0153 | H | H | H | H | H | O | H | H | 2-Me-5-Cl-吡啶-3-基 | 0 |
B-0154 | H | H | H | H | H | O | H | H | 2-Me-6-Cl-吡啶-3-基 | 0 |
B-0155 | H | H | H | H | H | O | H | H | 4-Me-5-Cl-吡啶-3-基 | 0 |
B-0156 | H | H | H | H | H | O | H | H | 4-Me-6-Cl-吡啶-3-基 | 0 |
B-0157 | H | H | H | H | H | O | H | H | 2,4-(Me)2-吡啶-3-基 | 0 |
B-0158 | H | H | H | H | H | O | H | H | 2,5-(Me)2-吡啶-3-基 | 0 |
B-0159 | H | H | H | H | H | O | H | H | 2,6-(Me)2-吡啶-3-基 | 0 |
B-0160 | H | H | H | H | H | O | H | H | 4,5-(Me)2-吡啶-3-基 | 0 |
B-0161 | H | H | H | H | H | O | H | H | 4,6-(Me)2-吡啶-3-基 | 0 |
B-0162 | H | H | H | H | H | O | H | H | 2-Me-4-OMe-吡啶-3-基 | 0 |
B-0163 | H | H | H | H | H | O | H | H | 2-Me-5-OMe-吡啶-3-基 | 0 |
B-0164 | H | H | H | H | H | O | H | H | 2-Me-6-OMe-吡啶-3-基 | 0 |
B-0165 | H | H | H | H | H | O | H | H | 4-Me-2-OMe-吡啶-3-基 | 0 |
B-0166 | H | H | H | H | H | O | H | H | 4-Me-5-OMe-吡啶-3-基 | 0 |
[表181]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-0167 | H | H | H | H | H | O | H | H | 4-Me-6-OMe-吡啶-3-基 | 0 |
B-0168 | H | H | H | H | H | O | H | H | 2-CF3-4-F-吡啶-3-基 | 0 |
B-0169 | H | H | H | H | H | O | H | H | 2-CF3-5-F-吡啶-3-基 | 0 |
B-0170 | H | H | H | H | H | O | H | H | 2-CF3-6-F-吡啶-3-基 | 0 |
B-0171 | H | H | H | H | H | O | H | H | 4-CF3-2-F-吡啶-3-基 | 0 |
B-0172 | H | H | H | H | H | O | H | H | 4-CF3-5-F-吡啶-3-基 | 0 |
B-0173 | H | H | H | H | H | O | H | H | 4-CF3-6-F-吡啶-3-基 | 0 |
B-0174 | H | H | H | H | H | O | H | H | 2-CF3-4-Me-吡啶-3-基 | 0 |
B-0175 | H | H | H | H | H | O | H | H | 2-CF3-5-Me-吡啶-3-基 | 0 |
B-0176 | H | H | H | H | H | O | H | H | 2-CF3-6-Me-吡啶-3-基 | 0 |
B-0177 | H | H | H | H | H | O | H | H | 4-CF3-2-Me-吡啶-3-基 | 0 |
B-0178 | H | H | H | H | H | O | H | H | 4-CF3-5-Me-吡啶-3-基 | 0 |
B-0179 | H | H | H | H | H | O | H | H | 4-CF3-6-Me-吡啶-3-基 | 0 |
B-0180 | H | H | H | H | H | O | H | H | 2-OMe-5-F-吡啶-3-基 | 0 |
B-0181 | H | H | H | H | H | O | H | H | 2-OMe-6-F-吡啶-3-基 | 0 |
B-0182 | H | H | H | H | H | O | H | H | 4-OMe-5-F-吡啶-3-基 | 0 |
B-0183 | H | H | H | H | H | O | H | H | 4-OMe-6-F-吡啶-3-基 | 0 |
B-0184 | H | H | H | H | H | O | H | H | 2-OMe-4-Cl-吡啶-3-基 | 0 |
B-0185 | H | H | H | H | H | O | H | H | 2-OMe-5-Cl-吡啶-3-基 | 0 |
B-0186 | H | H | H | H | H | O | H | H | 2-OMe-6-Cl-吡啶-3-基 | 0 |
B-0187 | H | H | H | H | H | O | H | H | 4-OMe-2-Cl-吡啶-3-基 | 0 |
B-0188 | H | H | H | H | H | O | H | H | 4-OMe-5-Cl-吡啶-3-基 | 0 |
B-0189 | H | H | H | H | H | O | H | H | 4-OMe-6-Cl-吡啶-3-基 | 0 |
B-0190 | H | H | H | H | H | O | H | H | 2-OMe-5-Me-吡啶-3-基 | 0 |
B-0191 | H | H | H | H | H | O | H | H | 2-OMe-6-Me-吡啶-3-基 | 0 |
B-0192 | H | H | H | H | H | O | H | H | 4-OMe-5-Me-吡啶-3-基 | 0 |
B-0193 | H | H | H | H | H | O | H | H | 4-OMe-6-Me-吡啶-3-基 | 0 |
B-0194 | H | H | H | H | H | O | H | H | 2,4-(OMe)2-吡啶-3-基 | 0 |
B-0195 | H | H | H | H | H | O | H | H | 2,5-(OMe)2-吡啶-3-基 | 0 |
B-0196 | H | H | H | H | H | O | H | H | 2,6-(OMe)2-吡啶-3-基 | 0 |
B-0197 | H | H | H | H | H | O | H | H | 4,5-(OMe)2-吡啶-3-基 | 0 |
B-0198 | H | H | H | H | H | O | H | H | 4,6-(OMe)2-吡啶-3-基 | 0 |
B-0199 | H | H | H | H | H | O | H | H | 吡啶-4-基 | 0 |
B-0200 | H | H | H | H | H | O | H | H | 2-F-吡啶-4-基 | 0 |
B-0201 | H | H | H | H | H | O | H | H | 3-F-吡啶-4-基 | 0 |
B-0202 | H | H | H | H | H | O | H | H | 2-Cl-吡啶-4-基 | 0 |
B-0203 | H | H | H | H | H | O | H | H | 3-Cl-吡啶-4-基 | 0 |
B-0204 | H | H | H | H | H | O | H | H | 2-Me-吡啶-4-基 | 0 |
B-0205 | H | H | H | H | H | O | H | H | 3-Me-吡啶-4-基 | 0 |
B-0206 | H | H | H | H | H | O | H | H | 2-CF3-吡啶-4-基 | 0 |
B-0207 | H | H | H | H | H | O | H | H | 3-CF3-吡啶-4-基 | 0 |
B-0208 | H | H | H | H | H | O | H | H | 2-OMe-吡啶-4-基 | 0 |
B-0209 | H | H | H | H | H | O | H | H | 3-OMe-吡啶-4-基 | 0 |
B-0210 | H | H | H | H | H | O | H | H | 2,3-F2-吡啶-4-基 | 0 |
B-0211 | H | H | H | H | H | O | H | H | 2,5-F2-吡啶-4-基 | 0 |
B-0212 | H | H | H | H | H | O | H | H | 2,6-F2-吡啶-4-基 | 0 |
B-0213 | H | H | H | H | H | O | H | H | 3,5-F2-吡啶-4-基 | 0 |
B-0214 | H | H | H | H | H | O | H | H | 2,3-Cl2-吡啶-4-基 | 0 |
B-0215 | H | H | H | H | H | O | H | H | 2,5-Cl2-吡啶-4-基 | 0 |
B-0216 | H | H | H | H | H | O | H | H | 2,6-Cl2-吡啶-4-基 | 0 |
B-0217 | H | H | H | H | H | O | H | H | 3,5-Cl2-吡啶-4-基 | 0 |
B-0218 | H | H | H | H | H | O | H | H | 3-F-2-Cl-吡啶-4-基 | 0 |
B-0219 | H | H | H | H | H | O | H | H | 3-F-5-Cl-吡啶-4-基 | 0 |
B-0220 | H | H | H | H | H | O | H | H | 3-F-6-Cl-吡啶-4-基 | 0 |
B-0221 | H | H | H | H | H | O | H | H | 3-F-2-Me-吡啶-4-基 | 0 |
B-0222 | H | H | H | H | H | O | H | H | 3-F-5-Me-吡啶-4-基 | 0 |
B-0223 | H | H | H | H | H | O | H | H | 3-F-6-Me-吡啶-4-基 | 0 |
[表182]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-0224 | H | H | H | H | H | O | H | H | 3-F-2-OMe-吡啶-4-基 | 0 |
B-0225 | H | H | H | H | H | O | H | H | 3-F-5-OMe-吡啶-4-基 | 0 |
B-0226 | H | H | H | H | H | O | H | H | 3-F-6-OMe-吡啶-4-基 | 0 |
B-0227 | H | H | H | H | H | O | H | H | 3-Cl-2-F-吡啶-4-基 | 0 |
B-0228 | H | H | H | H | H | O | H | H | 3-Cl-6-F-吡啶-4-基 | 0 |
B-0229 | H | H | H | H | H | O | H | H | 3-Cl-2-Me-吡啶-4-基 | 0 |
B-0230 | H | H | H | H | H | O | H | H | 3-Cl-5-Me-吡啶-4-基 | 0 |
B-0231 | H | H | H | H | H | O | H | H | 3-Cl-6-Me-吡啶-4-基 | 0 |
B-0232 | H | H | H | H | H | O | H | H | 3-Me-2-F-吡啶-4-基 | 0 |
B-0233 | H | H | H | H | H | O | H | H | 3-Me-6-F-吡啶-4-基 | 0 |
B-0234 | H | H | H | H | H | O | H | H | 3-Me-2-Cl-吡啶-4-基 | 0 |
B-0235 | H | H | H | H | H | O | H | H | 3-Me-6-Cl-吡啶-4-基 | 0 |
B-0236 | H | H | H | H | H | O | H | H | 2,3-(Me)2-吡啶-4-基 | 0 |
B-0237 | H | H | H | H | H | O | H | H | 3,5-(Me)2-吡啶-4-基 | 0 |
B-0238 | H | H | H | H | H | O | H | H | 3,6-(Me)2-吡啶-4-基 | 0 |
B-0239 | H | H | H | H | H | O | H | H | 3-Me-2-OMe-吡啶-4-基 | 0 |
B-0240 | H | H | H | H | H | O | H | H | 3-Me-5-OMe-吡啶-4-基 | 0 |
B-0241 | H | H | H | H | H | O | H | H | 3-Me-6-OMe-吡啶-4-基 | 0 |
B-0242 | H | H | H | H | H | O | H | H | 3-CF3-2-F-吡啶-4-基 | 0 |
B-0243 | H | H | H | H | H | O | H | H | 3-CF3-5-F-吡啶-4-基 | 0 |
B-0244 | H | H | H | H | H | O | H | H | 3-CF3-6-F-吡啶-4-基 | 0 |
B-0245 | H | H | H | H | H | O | H | H | 3-CF3-2-Me-吡啶-4-基 | 0 |
B-0246 | H | H | H | H | H | O | H | H | 3-CF3-5-Me-吡啶-4-基 | 0 |
B-0247 | H | H | H | H | H | O | H | H | 3-CF3-6-Me-吡啶-4-基 | 0 |
B-0248 | H | H | H | H | H | O | H | H | 3-OMe-2-F-吡啶-4-基 | 0 |
B-0249 | H | H | H | H | H | O | H | H | 3-OMe-6-F-吡啶-4-基 | 0 |
B-0250 | H | H | H | H | H | O | H | H | 3-OMe-2-Cl-吡啶-4-基 | 0 |
B-0251 | H | H | H | H | H | O | H | H | 3-OMe-5-Cl-吡啶-4-基 | 0 |
B-0252 | H | H | H | H | H | O | H | H | 3-OMe-6-Cl-吡啶-4-基 | 0 |
B-0253 | H | H | H | H | H | O | H | H | 3-OMe-2-Me-吡啶-4-基 | 0 |
B-0254 | H | H | H | H | H | O | H | H | 3-OMe-6-Me-吡啶-4-基 | 0 |
B-0255 | H | H | H | H | H | O | H | H | 2,3-(OMe)2-吡啶-4-基 | 0 |
B-0256 | H | H | H | H | H | O | H | H | 3,5-(OMe)2-吡啶-4-基 | 0 |
B-0257 | H | H | H | H | H | O | H | H | 3,6-(OMe)2-吡啶-4-基 | 0 |
B-0258 | H | H | H | H | H | O | H | H | 嘧啶-2-基 | 0 |
B-0259 | H | H | H | H | H | O | H | H | 嘧啶-4-基 | 0 |
B-0260 | H | H | H | H | H | O | H | H | 5-F-嘧啶-4-基 | 0 |
B-0261 | H | H | H | H | H | O | H | H | 5-Me-嘧啶-4-基 | 0 |
B-0262 | H | H | H | H | H | O | H | H | 5-CF3-嘧啶-4-基 | 0 |
B-0263 | H | H | H | H | H | O | H | H | 5-OMe-嘧啶-4-基 | 0 |
B-0264 | H | H | H | H | H | O | H | H | 嘧啶-5-基 | 0 |
B-0265 | H | H | H | H | H | O | H | H | 4-F-嘧啶-5-基 | 0 |
B-0266 | H | H | H | H | H | O | H | H | 4-Cl-嘧啶-5-基 | 0 |
B-0267 | H | H | H | H | H | O | H | H | 4-Me-嘧啶-5-基 | 0 |
B-0268 | H | H | H | H | H | O | H | H | 4-CF3-嘧啶-5-基 | 0 |
B-0269 | H | H | H | H | H | O | H | H | 4-OMe-嘧啶-5-基 | 0 |
B-0270 | H | H | H | H | H | O | H | H | 哒嗪-3-基 | 0 |
B-0271 | H | H | H | H | H | O | H | H | 4-F-哒嗪-3-基 | 0 |
B-0272 | H | H | H | H | H | O | H | H | 4-Cl-哒嗪-3-基 | 0 |
B-0273 | H | H | H | H | H | O | H | H | 4-Me-哒嗪-3-基 | 0 |
B-0274 | H | H | H | H | H | O | H | H | 4-CF3-哒嗪-3-基 | 0 |
B-0275 | H | H | H | H | H | O | H | H | 4-OMe-哒嗪-3-基 | 0 |
B-0276 | H | H | H | H | H | O | H | H | 哒嗪-4-基 | 0 |
B-0277 | H | H | H | H | H | O | H | H | 3-F-哒嗪-4-基 | 0 |
B-0278 | H | H | H | H | H | O | H | H | 3-Cl-哒嗪-4-基 | 0 |
B-0279 | H | H | H | H | H | O | H | H | 3-Me-哒嗪-4-基 | 0 |
B-0280 | H | H | H | H | H | O | H | H | 3-CF3-哒嗪-4-基 | 0 |
[表183]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-0281 | H | H | H | H | H | O | H | H | 3-OMe-哒嗪-4-基 | 0 |
B-0282 | H | H | H | H | H | O | H | H | 5-F-哒嗪-4-基 | 0 |
B-0283 | H | H | H | H | H | O | H | H | 5-Cl-哒嗪-4-基 | 0 |
B-0284 | H | H | H | H | H | O | H | H | 5-Me-哒嗪-4-基 | 0 |
B-0285 | H | H | H | H | H | O | H | H | 5-CF3-哒嗪-4-基 | 0 |
B-0286 | H | H | H | H | H | O | H | H | 5-OMe-哒嗪-4-基 | 0 |
B-0287 | H | H | H | H | H | O | H | H | 噻吩-2-基 | 0 |
B-0288 | H | H | H | H | H | O | H | H | 3-F-噻吩-2-基 | 0 |
B-0289 | H | H | H | H | H | O | H | H | 3-Cl-噻吩-2-基 | 0 |
B-0290 | H | H | H | H | H | O | H | H | 3-Me-噻吩-2-基 | 0 |
B-0291 | H | H | H | H | H | O | H | H | 3-CF3-噻吩-2-基 | 0 |
B-0292 | H | H | H | H | H | O | H | H | 3-OMe-噻吩-2-基 | 0 |
B-0293 | H | H | H | H | H | O | H | H | 噻吩-3-基 | 0 |
B-0294 | H | H | H | H | H | O | H | H | 2-F-噻吩-3-基 | 0 |
B-0295 | H | H | H | H | H | O | H | H | 2-Cl-噻吩-3-基 | 0 |
B-0296 | H | H | H | H | H | O | H | H | 2-Me-噻吩-3-基 | 0 |
B-0297 | H | H | H | H | H | O | H | H | 2-CF3-噻吩-3-基 | 0 |
B-0298 | H | H | H | H | H | O | H | H | 2-OMe-噻吩-3-基 | 0 |
B-0299 | H | H | H | H | H | O | H | H | 4-F-噻吩-3-基 | 0 |
B-0300 | H | H | H | H | H | O | H | H | 4-Cl-噻吩-3-基 | 0 |
B-0301 | H | H | H | H | H | O | H | H | 4-Me-噻吩-3-基 | 0 |
B-0302 | H | H | H | H | H | O | H | H | 4-CF3-噻吩-3-基 | 0 |
B-0303 | H | H | H | H | H | O | H | H | 4-OMe-噻吩-3-基 | 0 |
B-0304 | H | H | H | H | H | O | H | H | 噻唑-2-基 | 0 |
B-0305 | H | H | H | H | H | O | H | H | 噻唑-4-基 | 0 |
B-0306 | H | H | H | H | H | O | H | H | 5-F-噻唑-4-基 | 0 |
B-0307 | H | H | H | H | H | O | H | H | 5-Me-噻唑-4-基 | 0 |
B-0308 | H | H | H | H | H | O | H | H | 5-CF3-噻唑-4-基 | 0 |
B-0309 | H | H | H | H | H | O | H | H | 5-OMe-噻唑-4-基 | 0 |
B-0310 | H | H | H | H | H | O | H | H | 噻唑-5-基 | 0 |
B-0311 | H | H | H | H | H | O | H | H | 4-F-噻唑-5-基 | 0 |
B-0312 | H | H | H | H | H | O | H | H | 4-Me-噻唑-5-基 | 0 |
B-0313 | H | H | H | H | H | O | H | H | 4-CF3-噻唑-5-基 | 0 |
B-0314 | H | H | H | H | H | O | H | H | 4-OMe-噻唑-5-基 | 0 |
B-0315 | H | H | H | H | H | O | H | H | 1H-吡咯-1-基 | 0 |
B-0316 | H | H | H | H | H | O | H | H | 2-F-1H-吡咯-1-基 | 0 |
B-0317 | H | H | H | H | H | O | H | H | 2-Me-1H-吡咯-1-基 | 0 |
B-0318 | H | H | H | H | H | O | H | H | 2-CF3-1H-吡咯-1-基 | 0 |
B-0319 | H | H | H | H | H | O | H | H | 2-OMe-1H-吡咯-1-基 | 0 |
B-0320 | H | H | H | H | H | O | H | H | 1H-吡咯-2-基 | 0 |
B-0321 | H | H | H | H | H | O | H | H | 1-Me-1H-吡咯-2-基 | 0 |
B-0322 | H | H | H | H | H | O | H | H | 3-F-1H-吡咯-2-基 | 0 |
B-0323 | H | H | H | H | H | O | H | H | 3-Me-1H-吡咯-2-基 | 0 |
B-0324 | H | H | H | H | H | O | H | H | 3-CF3-1H-吡咯-2-基 | 0 |
B-0325 | H | H | H | H | H | O | H | H | 3-OMe-1H-吡咯-2-基 | 0 |
B-0326 | H | H | H | H | H | O | H | H | 1-Me-3-F-1H-吡咯-2-基 | 0 |
B-0327 | H | H | H | H | H | O | H | H | 1,3-(Me)2-1H-吡咯-2-基 | 0 |
B-0328 | H | H | H | H | H | O | H | H | 1-Me-3-CF3-1H-吡咯-2-基 | 0 |
B-0329 | H | H | H | H | H | O | H | H | 1-Me-3-OMe-1H-吡咯-2-基 | 0 |
B-0330 | H | H | H | H | H | O | H | H | 1H-吡咯-3-基 | 0 |
B-0331 | H | H | H | H | H | O | H | H | 1-Me-1H-吡咯-3-基 | 0 |
B-0332 | H | H | H | H | H | O | H | H | 2-F-1H-吡咯-3-基 | 0 |
B-0333 | H | H | H | H | H | O | H | H | 2-Me-1H-吡咯-3-基 | 0 |
B-0334 | H | H | H | H | H | O | H | H | 2-CF3-1H-吡咯-3-基 | 0 |
B-0335 | H | H | H | H | H | O | H | H | 2-OMe-1H-吡咯-3-基 | 0 |
B-0336 | H | H | H | H | H | O | H | H | 1-Me-2-F-1H-吡咯-3-基 | 0 |
B-0337 | H | H | H | H | H | O | H | H | 1,2-(Me)2-1H-吡咯-3-基 | 0 |
[表184]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-0338 | H | H | H | H | H | O | H | H | 1-Me-2-CF3-1H-吡咯-3-基 | 0 |
B-0339 | H | H | H | H | H | O | H | H | 1-Me-2-OMe-1H-吡咯-3-基 | 0 |
B-0340 | H | H | H | H | H | O | H | H | 4-F-1H-吡咯-3-基 | 0 |
B-0341 | H | H | H | H | H | O | H | H | 4-Me-1H-吡咯-3-基 | 0 |
B-0342 | H | H | H | H | H | O | H | H | 4-CF3-1H-吡咯-3-基 | 0 |
B-0343 | H | H | H | H | H | O | H | H | 4-OMe-1H-吡咯-3-基 | 0 |
B-0344 | H | H | H | H | H | O | H | H | 1-Me-4-F-1H-吡咯-3-基 | 0 |
B-0345 | H | H | H | H | H | O | H | H | 1,4-(Me)2-1H-吡咯-3-基 | 0 |
B-0346 | H | H | H | H | H | O | H | H | 1-Me-4-CF3-1H-吡咯-3-基 | 0 |
B-0347 | H | H | H | H | H | O | H | H | 1-Me-4-OMe-1H-吡咯-3-基 | 0 |
B-0348 | H | H | H | H | H | O | H | H | 1H-吡唑-1-基 | 0 |
B-0349 | H | H | H | H | H | O | H | H | 5-F-1H-吡唑-1-基 | 0 |
B-0350 | H | H | H | H | H | O | H | H | 5-Cl-1H-吡唑-1-基 | 0 |
B-0351 | H | H | H | H | H | O | H | H | 5-Me-1H-吡唑-1-基 | 0 |
B-0352 | H | H | H | H | H | O | H | H | 5-CF3-1H-吡唑-1-基 | 0 |
B-0353 | H | H | H | H | H | O | H | H | 5-OMe-1H-吡唑-1-基 | 0 |
B-0354 | H | H | H | H | H | O | H | H | 1H-吡唑-3-基 | 0 |
B-0355 | H | H | H | H | H | O | H | H | 1-Me-1H-吡唑-3-基 | 0 |
B-0356 | H | H | H | H | H | O | H | H | 4-F-1H-吡唑-3-基 | 0 |
B-0357 | H | H | H | H | H | O | H | H | 4-Cl-1H-吡唑-3-基 | 0 |
B-0358 | H | H | H | H | H | O | H | H | 4-Me-1H-吡唑-3-基 | 0 |
B-0359 | H | H | H | H | H | O | H | H | 4-CF3-1H-吡唑-3-基 | 0 |
B-0360 | H | H | H | H | H | O | H | H | 4-OMe-1H-吡唑-3-基 | 0 |
B-0361 | H | H | H | H | H | O | H | H | 1-Me-4-F-1H-吡唑-3-基 | 0 |
B-0362 | H | H | H | H | H | O | H | H | 1-Me-4-Cl-1H-吡唑-3-基 | 0 |
B-0363 | H | H | H | H | H | O | H | H | 1,4-(Me)2-1H-吡唑-3-基 | 0 |
B-0364 | H | H | H | H | H | O | H | H | 1-Me-4-CF3-1H-吡唑-3-基 | 0 |
B-0365 | H | H | H | H | H | O | H | H | 1-Me-4-OMe-1H-吡唑-3-基 | 0 |
B-0366 | H | H | H | H | H | O | H | H | 1H-吡唑-4-基 | 0 |
B-0367 | H | H | H | H | H | O | H | H | 1-Me-1H-吡唑-4-基 | 0 |
B-0368 | H | H | H | H | H | O | H | H | 3-F-1H-吡唑-4-基 | 0 |
B-0369 | H | H | H | H | H | O | H | H | 3-Cl-1H-吡唑-4-基 | 0 |
B-0370 | H | H | H | H | H | O | H | H | 3-Me-1H-吡唑-4-基 | 0 |
B-0371 | H | H | H | H | H | O | H | H | 3-CF3-1H-吡唑-4-基 | 0 |
B-0372 | H | H | H | H | H | O | H | H | 3-OMe-1H-吡唑-4-基 | 0 |
B-0373 | H | H | H | H | H | O | H | H | 1-Me-3-F-1H-吡唑-4-基 | 0 |
B-0374 | H | H | H | H | H | O | H | H | 1-Me-3-Cl-1H-吡唑-4-基 | 0 |
B-0375 | H | H | H | H | H | O | H | H | 1,3-(Me)2-1H-吡唑-4-基 | 0 |
B-0376 | H | H | H | H | H | O | H | H | 1-Me-3-CF3-1H-吡唑-4-基 | 0 |
B-0377 | H | H | H | H | H | O | H | H | 1-Me-3-OMe-1H-吡唑-4-基 | 0 |
B-0378 | H | H | H | H | H | O | H | H | 5-F-1H-吡唑-4-基 | 0 |
B-0379 | H | H | H | H | H | O | H | H | 5-Cl-1H-吡唑-4-基 | 0 |
B-0380 | H | H | H | H | H | O | H | H | 5-Me-1H-吡唑-4-基 | 0 |
B-0381 | H | H | H | H | H | O | H | H | 5-CF3-1H-吡唑-4-基 | 0 |
B-0382 | H | H | H | H | H | O | H | H | 5-OMe-1H-吡唑-4-基 | 0 |
B-0383 | H | H | H | H | H | O | H | H | 1-Me-5-F-1H-吡唑-4-基 | 0 |
B-0384 | H | H | H | H | H | O | H | H | 1-Me-5-Cl-1H-吡唑-4-基 | 0 |
B-0385 | H | H | H | H | H | O | H | H | 1,5-(Me)2-1H-吡唑-4-基 | 0 |
B-0386 | H | H | H | H | H | O | H | H | 1-Me-5-CF3-1H-吡唑-4-基 | 0 |
B-0387 | H | H | H | H | H | O | H | H | 1-Me-5-OMe-1H-吡唑-4-基 | 0 |
B-0388 | H | H | H | H | H | O | H | H | 1H-吡唑-5-基 | 0 |
B-0389 | H | H | H | H | H | O | H | H | 1-Me-1H-吡唑-5-基 | 0 |
B-0390 | H | H | H | H | H | O | H | H | 4-F-1H-吡唑-5-基 | 0 |
B-0391 | H | H | H | H | H | O | H | H | 4-Cl-1H-吡唑-5-基 | 0 |
B-0392 | H | H | H | H | H | O | H | H | 4-Me-1H-吡唑-5-基 | 0 |
B-0393 | H | H | H | H | H | O | H | H | 4-CF3-1H-吡唑-5-基 | 0 |
B-0394 | H | H | H | H | H | O | H | H | 4-OMe-1H-吡唑-5-基 | 0 |
[表185]
[表186]
[表187]
[表188]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-5053 | H | H | H | H | H | O | H | H | 3-F-6-OMe-吡啶-2-基 | 1 |
B-5054 | H | H | H | H | H | O | H | H | 3-Cl-4-F-吡啶-2-基 | 1 |
B-5055 | H | H | H | H | H | O | H | H | 3-Cl-5-F-吡啶-2-基 | 1 |
B-5056 | H | H | H | H | H | O | H | H | 3-Cl-6-F-吡啶-2-基 | 1 |
B-5057 | H | H | H | H | H | O | H | H | 3-Cl-4-Me-吡啶-2-基 | 1 |
B-5058 | H | H | H | H | H | O | H | H | 3-Cl-5-Me-吡啶-2-基 | 1 |
B-5059 | H | H | H | H | H | O | H | H | 3-Cl-6-Me-吡啶-2-基 | 1 |
B-5060 | H | H | H | H | H | O | H | H | 3-Me-4-F-吡啶-2-基 | 1 |
B-5061 | H | H | H | H | H | O | H | H | 3-Me-5-F-吡啶-2-基 | 1 |
B-5062 | H | H | H | H | H | O | H | H | 3-Me-6-F-吡啶-2-基 | 1 |
B-5063 | H | H | H | H | H | O | H | H | 3-Me-4-Cl-吡啶-2-基 | 1 |
B-5064 | H | H | H | H | H | O | H | H | 3-Me-5-Cl-吡啶-2-基 | 1 |
B-5065 | H | H | H | H | H | O | H | H | 3-Me-6-Cl-吡啶-2-基 | 1 |
B-5066 | H | H | H | H | H | O | H | H | 3,4-(Me)2-吡啶-2-基 | 1 |
B-5067 | H | H | H | H | H | O | H | H | 3,5-(Me)2-吡啶-2-基 | 1 |
B-5068 | H | H | H | H | H | O | H | H | 3,6-(Me)2-吡啶-2-基 | 1 |
B-5069 | H | H | H | H | H | O | H | H | 3-Me-4-OMe-吡啶-2-基 | 1 |
B-5070 | H | H | H | H | H | O | H | H | 3-Me-5-OMe-吡啶-2-基 | 1 |
B-5071 | H | H | H | H | H | O | H | H | 3-Me-6-OMe-吡啶-2-基 | 1 |
B-5072 | H | H | H | H | H | O | H | H | 3-CF3-4-F-吡啶-2-基 | 1 |
B-5073 | H | H | H | H | H | O | H | H | 3-CF3-5-F-吡啶-2-基 | 1 |
B-5074 | H | H | H | H | H | O | H | H | 3-CF3-6-F-吡啶-2-基 | 1 |
B-5075 | H | H | H | H | H | O | H | H | 3-CF3-4-Me-吡啶-2-基 | 1 |
B-5076 | H | H | H | H | H | O | H | H | 3-CF3-5-Me-吡啶-2-基 | 1 |
B-5077 | H | H | H | H | H | O | H | H | 3-CF3-6-Me-吡啶-2-基 | 1 |
B-5078 | H | H | H | H | H | O | H | H | 3-OMe-4-F-吡啶-2-基 | 1 |
B-5079 | H | H | H | H | H | O | H | H | 3-OMe-5-F-吡啶-2-基 | 1 |
B-5080 | H | H | H | H | H | O | H | H | 3-OMe-6-F-吡啶-2-基 | 1 |
B-5081 | H | H | H | H | H | O | H | H | 3-OMe-4-Cl-吡啶-2-基 | 1 |
B-5082 | H | H | H | H | H | O | H | H | 3-OMe-5-Cl-吡啶-2-基 | 1 |
B-5083 | H | H | H | H | H | O | H | H | 3-OMe-6-Cl-吡啶-2-基 | 1 |
B-5084 | H | H | H | H | H | O | H | H | 3-OMe-4-Me-吡啶-2-基 | 1 |
B-5085 | H | H | H | H | H | O | H | H | 3-OMe-5-Me-吡啶-2-基 | 1 |
B-5086 | H | H | H | H | H | O | H | H | 3-OMe-6-Me-吡啶-2-基 | 1 |
B-5087 | H | H | H | H | H | O | H | H | 3,4-(OMe)2-吡啶-2-基 | 1 |
B-5088 | H | H | H | H | H | O | H | H | 3,5-(OMe)2-吡啶-2-基 | 1 |
B-5089 | H | H | H | H | H | O | H | H | 3,6-(OMe)2-吡啶-2-基 | 1 |
B-5090 | H | H | H | H | H | O | H | H | 吡啶-3-基 | 1 |
B-5091 | H | H | H | H | H | O | H | H | 2-F-吡啶-3-基 | 1 |
B-5092 | H | H | H | H | H | O | H | H | 4-F-吡啶-3-基 | 1 |
B-5093 | H | H | H | H | H | O | H | H | 5-F-吡啶-3-基 | 1 |
B-5094 | H | H | H | H | H | O | H | H | 6-F-吡啶-3-基 | 1 |
B-5095 | H | H | H | H | H | O | H | H | 2-Cl-吡啶-3-基 | 1 |
B-5096 | H | H | H | H | H | O | H | H | 4-Cl-吡啶-3-基 | 1 |
B-5097 | H | H | H | H | H | O | H | H | 5-Cl-吡啶-3-基 | 1 |
B-5098 | H | H | H | H | H | O | H | H | 6-Cl-吡啶-3-基 | 1 |
B-5099 | H | H | H | H | H | O | H | H | 2-Me-吡啶-3-基 | 1 |
B-5100 | H | H | H | H | H | O | H | H | 4-Me-吡啶-3-基 | 1 |
B-5101 | H | H | H | H | H | O | H | H | 5-Me-吡啶-3-基 | 1 |
B-5102 | H | H | H | H | H | O | H | H | 6-Me-吡啶-3-基 | 1 |
B-5103 | H | H | H | H | H | O | H | H | 2-CF3-吡啶-3-基 | 1 |
B-5104 | H | H | H | H | H | O | H | H | 4-CF3-吡啶-3-基 | 1 |
B-5105 | H | H | H | H | H | O | H | H | 5-CF3-吡啶-3-基 | 1 |
B-5106 | H | H | H | H | H | O | H | H | 6-CF3-吡啶-3-基 | 1 |
B-5107 | H | H | H | H | H | O | H | H | 2-OMe-吡啶-3-基 | 1 |
B-5108 | H | H | H | H | H | O | H | H | 4-OMe-吡啶-3-基 | 1 |
B-5109 | H | H | H | H | H | O | H | H | 5-OMe-吡啶-3-基 | 1 |
[表189]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-5110 | H | H | H | H | H | O | H | H | 6-OMe-吡啶-3-基 | 1 |
B-5111 | H | H | H | H | H | O | H | H | 2,4-F2-吡啶-3-基 | 1 |
B-5112 | H | H | H | H | H | O | H | H | 2,5-F2-吡啶-3-基 | 1 |
B-5113 | H | H | H | H | H | O | H | H | 2,6-F2-吡啶-3-基 | 1 |
B-5114 | H | H | H | H | H | O | H | H | 4,5-F2-吡啶-3-基 | 1 |
B-5115 | H | H | H | H | H | O | H | H | 4,6-F2-吡啶-3-基 | 1 |
B-5116 | H | H | H | H | H | O | H | H | 2,4-Cl2-吡啶-3-基 | 1 |
B-5117 | H | H | H | H | H | O | H | H | 2,5-Cl2-吡啶-3-基 | 1 |
B-5118 | H | H | H | H | H | O | H | H | 2,6-Cl2-吡啶-3-基 | 1 |
B-5119 | H | H | H | H | H | O | H | H | 4,5-Cl2-吡啶-3-基 | 1 |
B-5120 | H | H | H | H | H | O | H | H | 4,6-Cl2-吡啶-3-基 | 1 |
B-5121 | H | H | H | H | H | O | H | H | 2-F-4-Cl-吡啶-3-基 | 1 |
B-5122 | H | H | H | H | H | O | H | H | 2-F-5-Cl-吡啶-3-基 | 1 |
B-5123 | H | H | H | H | H | O | H | H | 2-F-6-Cl-吡啶-3-基 | 1 |
B-5124 | H | H | H | H | H | O | H | H | 4-F-2-Cl-吡啶-3-基 | 1 |
B-5125 | H | H | H | H | H | O | H | H | 4-F-5-Cl-吡啶-3-基 | 1 |
B-5126 | H | H | H | H | H | O | H | H | 4-F-6-Cl-吡啶-3-基 | 1 |
B-5127 | H | H | H | H | H | O | H | H | 2-F-4-Me-吡啶-3-基 | 1 |
B-5128 | H | H | H | H | H | O | H | H | 2-F-5-Me-吡啶-3-基 | 1 |
B-5129 | H | H | H | H | H | O | H | H | 2-F-6-Me-吡啶-3-基 | 1 |
B-5130 | H | H | H | H | H | O | H | H | 4-F-2-Me-吡啶-3-基 | 1 |
B-5131 | H | H | H | H | H | O | H | H | 4-F-5-Me-吡啶-3-基 | 1 |
B-5132 | H | H | H | H | H | O | H | H | 4-F-6-Me-吡啶-3-基 | 1 |
B-5133 | H | H | H | H | H | O | H | H | 2-F-4-OMe-吡啶-3-基 | 1 |
B-5134 | H | H | H | H | H | O | H | H | 2-F-5-OMe-吡啶-3-基 | 1 |
B-5135 | H | H | H | H | H | O | H | H | 2-F-6-OMe-吡啶-3-基 | 1 |
B-5136 | H | H | H | H | H | O | H | H | 4-F-2-OMe-吡啶-3-基 | 1 |
B-5137 | H | H | H | H | H | O | H | H | 4-F-5-OMe-吡啶-3-基 | 1 |
B-5138 | H | H | H | H | H | O | H | H | 4-F-6-OMe-吡啶-3-基 | 1 |
B-5139 | H | H | H | H | H | O | H | H | 2-Cl-5-F-吡啶-3-基 | 1 |
B-5140 | H | H | H | H | H | O | H | H | 2-Cl-6-F-吡啶-3-基 | 1 |
B-5141 | H | H | H | H | H | O | H | H | 4-Cl-5-F-吡啶-3-基 | 1 |
B-5142 | H | H | H | H | H | O | H | H | 4-Cl-6-F-吡啶-3-基 | 1 |
B-5143 | H | H | H | H | H | O | H | H | 2-Cl-4-Me-吡啶-3-基 | 1 |
B-5144 | H | H | H | H | H | O | H | H | 2-Cl-5-Me-吡啶-3-基 | 1 |
B-5145 | H | H | H | H | H | O | H | H | 2-Cl-6-Me-吡啶-3-基 | 1 |
B-5146 | H | H | H | H | H | O | H | H | 4-Cl-2-Me-吡啶-3-基 | 1 |
B-5147 | H | H | H | H | H | O | H | H | 4-Cl-5-Me-吡啶-3-基 | 1 |
B-5148 | H | H | H | H | H | O | H | H | 4-Cl-6-Me-吡啶-3-基 | 1 |
B-5149 | H | H | H | H | H | O | H | H | 2-Me-5-F-吡啶-3-基 | 1 |
B-5150 | H | H | H | H | H | O | H | H | 2-Me-6-F-吡啶-3-基 | 1 |
B-5151 | H | H | H | H | H | O | H | H | 4-Me-5-F-吡啶-3-基 | 1 |
B-5152 | H | H | H | H | H | O | H | H | 4-Me-6-F-吡啶-3-基 | 1 |
B-5153 | H | H | H | H | H | O | H | H | 2-Me-5-Cl-吡啶-3-基 | 1 |
B-5154 | H | H | H | H | H | O | H | H | 2-Me-6-Cl-吡啶-3-基 | 1 |
B-5155 | H | H | H | H | H | O | H | H | 4-Me-5-Cl-吡啶-3-基 | 1 |
B-5156 | H | H | H | H | H | O | H | H | 4-Me-6-Cl-吡啶-3-基 | 1 |
B-5157 | H | H | H | H | H | O | H | H | 2,4-(Me)2-吡啶-3-基 | 1 |
B-5158 | H | H | H | H | H | O | H | H | 2,5-(Me)2-吡啶-3-基 | 1 |
B-5159 | H | H | H | H | H | O | H | H | 2,6-(Me)2-吡啶-3-基 | 1 |
B-5160 | H | H | H | H | H | O | H | H | 4,5-(Me)2-吡啶-3-基 | 1 |
B-5161 | H | H | H | H | H | O | H | H | 4,6-(Me)2-吡啶-3-基 | 1 |
B-5162 | H | H | H | H | H | O | H | H | 2-Me-4-OMe-吡啶-3-基 | 1 |
B-5163 | H | H | H | H | H | O | H | H | 2-Me-5-OMe-吡啶-3-基 | 1 |
B-5164 | H | H | H | H | H | O | H | H | 2-Me-6-OMe-吡啶-3-基 | 1 |
B-5165 | H | H | H | H | H | O | H | H | 4-Me-2-OMe-吡啶-3-基 | 1 |
B-5166 | H | H | H | H | H | O | H | H | 4-Me-5-OMe-吡啶-3-基 | 1 |
[表190]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-5167 | H | H | H | H | H | O | H | H | 4-Me-6-OMe-吡啶-3-基 | 1 |
B-5168 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub>-4-F-吡啶-3-基 | 1 |
B-5169 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub>-5-F-吡啶-3-基 | 1 |
B-5170 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub>-6-F-吡啶-3-基 | 1 |
B-5171 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-2-F-吡啶-3-基 | 1 |
B-5172 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-5-F-吡啶-3-基 | 1 |
B-5173 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-6-F-吡啶-3-基 | 1 |
B-5174 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub>-4-Me-吡啶-3-基 | 1 |
B-5175 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub>-5-Me-吡啶-3-基 | 1 |
B-5176 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub>-6-Me-吡啶-3-基 | 1 |
B-5177 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-2-Me-吡啶-3-基 | 1 |
B-5178 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-5-Me-吡啶-3-基 | 1 |
B-5179 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-6-Me-吡啶-3-基 | 1 |
B-5180 | H | H | H | H | H | O | H | H | 2-OMe-5-F-吡啶-3-基 | 1 |
B-5181 | H | H | H | H | H | O | H | H | 2-OMe-6-F-吡啶-3-基 | 1 |
B-5182 | H | H | H | H | H | O | H | H | 4-OMe-5-F-吡啶-3-基 | 1 |
B-5183 | H | H | H | H | H | O | H | H | 4-OMe-6-F-吡啶-3-基 | 1 |
B-5184 | H | H | H | H | H | O | H | H | 2-OMe-4-Cl-吡啶-3-基 | 1 |
B-5185 | H | H | H | H | H | O | H | H | 2-OMe-5-Cl-吡啶-3-基 | 1 |
B-5186 | H | H | H | H | H | O | H | H | 2-OMe-6-Cl-吡啶-3-基 | 1 |
B-5187 | H | H | H | H | H | O | H | H | 4-OMe-2-Cl-吡啶-3-基 | 1 |
B-5188 | H | H | H | H | H | O | H | H | 4-OMe-5-Cl-吡啶-3-基 | 1 |
B-5189 | H | H | H | H | H | O | H | H | 4-OMe-6-Cl-吡啶-3-基 | 1 |
B-5190 | H | H | H | H | H | O | H | H | 2-OMe-5-Me-吡啶-3-基 | 1 |
B-5191 | H | H | H | H | H | O | H | H | 2-OMe-6-Me-吡啶-3-基 | 1 |
B-5192 | H | H | H | H | H | O | H | H | 4-OMe-5-Me-吡啶-3-基 | 1 |
B-5193 | H | H | H | H | H | O | H | H | 4-OMe-6-Me-吡啶-3-基 | 1 |
B-5194 | H | H | H | H | H | O | H | H | 2,4-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
B-5195 | H | H | H | H | H | O | H | H | 2,5-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
B-5196 | H | H | H | H | H | O | H | H | 2,6-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
B-5197 | H | H | H | H | H | O | H | H | 4,5-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
B-5198 | H | H | H | H | H | O | H | H | 4,6-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
B-5199 | H | H | H | H | H | O | H | H | 吡啶-4-基 | 1 |
B-5200 | H | H | H | H | H | O | H | H | 2-F-吡啶-4-基 | 1 |
B-5201 | H | H | H | H | H | O | H | H | 3-F-吡啶-4-基 | 1 |
B-5202 | H | H | H | H | H | O | H | H | 2-Cl-吡啶-4-基 | 1 |
B-5203 | H | H | H | H | H | O | H | H | 3-Cl-吡啶-4-基 | 1 |
B-5204 | H | H | H | H | H | O | H | H | 2-Me-吡啶-4-基 | 1 |
B-5205 | H | H | H | H | H | O | H | H | 3-Me-吡啶-4-基 | 1 |
B-5206 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub>-吡啶-4-基 | 1 |
B-5207 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-吡啶-4-基 | 1 |
B-5208 | H | H | H | H | H | O | H | H | 2-OMe-吡啶-4-基 | 1 |
B-5209 | H | H | H | H | H | O | H | H | 3-OMe-吡啶-4-基 | 1 |
B-5210 | H | H | H | H | H | O | H | H | 2,3-F<sub>2</sub>-吡啶-4-基 | 1 |
B-5211 | H | H | H | H | H | O | H | H | 2,5-F<sub>2</sub>-吡啶-4-基 | 1 |
B-5212 | H | H | H | H | H | O | H | H | 2,6-F<sub>2</sub>-吡啶-4-基 | 1 |
B-5213 | H | H | H | H | H | O | H | H | 3,5-F<sub>2</sub>-吡啶-4-基 | 1 |
B-5214 | H | H | H | H | H | O | H | H | 2,3-Cl<sub>2</sub>-吡啶-4-基 | 1 |
B-5215 | H | H | H | H | H | O | H | H | 2,5-Cl<sub>2</sub>-吡啶-4-基 | 1 |
B-5216 | H | H | H | H | H | O | H | H | 2,6-Cl<sub>2</sub>-吡啶-4-基 | 1 |
B-5217 | H | H | H | H | H | O | H | H | 3,5-Cl<sub>2</sub>-吡啶-4-基 | 1 |
B-5218 | H | H | H | H | H | O | H | H | 3-F-2-Cl-吡啶-4-基 | 1 |
B-5219 | H | H | H | H | H | O | H | H | 3-F-5-Cl-吡啶-4-基 | 1 |
B-5220 | H | H | H | H | H | O | H | H | 3-F-6-Cl-吡啶-4-基 | 1 |
B-5221 | H | H | H | H | H | O | H | H | 3-F-2-Me-吡啶-4-基 | 1 |
B-5222 | H | H | H | H | H | O | H | H | 3-F-5-Me-吡啶-4-基 | 1 |
B-5223 | H | H | H | H | H | O | H | H | 3-F-6-Me-吡啶-4-基 | 1 |
[表191]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-5224 | H | H | H | H | H | O | H | H | 3-F-2-OMe-吡啶-4-基 | 1 |
B-5225 | H | H | H | H | H | O | H | H | 3-F-5-OMe-吡啶-4-基 | 1 |
B-5226 | H | H | H | H | H | O | H | H | 3-F-6-OMe-吡啶-4-基 | 1 |
B-5227 | H | H | H | H | H | O | H | H | 3-Cl-2-F-吡啶-4-基 | 1 |
B-5228 | H | H | H | H | H | O | H | H | 3-Cl-6-F-吡啶-4-基 | 1 |
B-5229 | H | H | H | H | H | O | H | H | 3-Cl-2-Me-吡啶-4-基 | 1 |
B-5230 | H | H | H | H | H | O | H | H | 3-Cl-5-Me-吡啶-4-基 | 1 |
B-5231 | H | H | H | H | H | O | H | H | 3-Cl-6-Me-吡啶-4-基 | 1 |
B-5232 | H | H | H | H | H | O | H | H | 3-Me-2-F-吡啶-4-基 | 1 |
B-5233 | H | H | H | H | H | O | H | H | 3-Me-6-F-吡啶-4-基 | 1 |
B-5234 | H | H | H | H | H | O | H | H | 3-Me-2-Cl-吡啶-4-基 | 1 |
B-5235 | H | H | H | H | H | O | H | H | 3-Me-6-Cl-吡啶-4-基 | 1 |
B-5236 | H | H | H | H | H | O | H | H | 2,3-(Me)<sub>2</sub>-吡啶-4-基 | 1 |
B-5237 | H | H | H | H | H | O | H | H | 3,5-(Me)<sub>2</sub>-吡啶-4-基 | 1 |
B-5238 | H | H | H | H | H | O | H | H | 3,6-(Me)<sub>2</sub>-吡啶-4-基 | 1 |
B-5239 | H | H | H | H | H | O | H | H | 3-Me-2-OMe-吡啶-4-基 | 1 |
B-5240 | H | H | H | H | H | O | H | H | 3-Me-5-OMe-吡啶-4-基 | 1 |
B-5241 | H | H | H | H | H | O | H | H | 3-Me-6-OMe-吡啶-4-基 | 1 |
B-5242 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-2-F-吡啶-4-基 | 1 |
B-5243 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-5-F-吡啶-4-基 | 1 |
B-5244 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-6-F-吡啶-4-基 | 1 |
B-5245 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-2-Me-吡啶-4-基 | 1 |
B-5246 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-5-Me-吡啶-4-基 | 1 |
B-5247 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-6-Me-吡啶-4-基 | 1 |
B-5248 | H | H | H | H | H | O | H | H | 3-OMe-2-F-吡啶-4-基 | 1 |
B-5249 | H | H | H | H | H | O | H | H | 3-OMe-6-F-吡啶-4-基 | 1 |
B-5250 | H | H | H | H | H | O | H | H | 3-OMe-2-Cl-吡啶-4-基 | 1 |
B-5251 | H | H | H | H | H | O | H | H | 3-OMe-5-Cl-吡啶-4-基 | 1 |
B-5252 | H | H | H | H | H | O | H | H | 3-OMe-6-Cl-吡啶-4-基 | 1 |
B-5253 | H | H | H | H | H | O | H | H | 3-OMe-2-Me-吡啶-4-基 | 1 |
B-5254 | H | H | H | H | H | O | H | H | 3-OMe-6-Me-吡啶-4-基 | 1 |
B-5255 | H | H | H | H | H | O | H | H | 2,3-(OMe)<sub>2</sub>-吡啶-4-基 | 1 |
B-5256 | H | H | H | H | H | O | H | H | 3,5-(OMe)<sub>2</sub>-吡啶-4-基 | 1 |
B-5257 | H | H | H | H | H | O | H | H | 3,6-(OMe)<sub>2</sub>-吡啶-4-基 | 1 |
B-5258 | H | H | H | H | H | O | H | H | 嘧啶-2-基 | 1 |
B-5259 | H | H | H | H | H | O | H | H | 嘧啶-4-基 | 1 |
B-5260 | H | H | H | H | H | O | H | H | 5-F-嘧啶-4-基 | 1 |
B-5261 | H | H | H | H | H | O | H | H | 5-Me-嘧啶-4-基 | 1 |
B-5262 | H | H | H | H | H | O | H | H | 5-CF3-嘧啶-4-基 | 1 |
B-5263 | H | H | H | H | H | O | H | H | 5-OMe-嘧啶-4-基 | 1 |
B-5264 | H | H | H | H | H | O | H | H | 嘧啶-5-基 | 1 |
B-5265 | H | H | H | H | H | O | H | H | 4-F-嘧啶-5-基 | 1 |
B-5266 | H | H | H | H | H | O | H | H | 4-Cl-嘧啶-5-基 | 1 |
B-5267 | H | H | H | H | H | O | H | H | 4-Me-嘧啶-5-基 | 1 |
B-5268 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-嘧啶-5-基 | 1 |
B-5269 | H | H | H | H | H | O | H | H | 4-OMe-嘧啶-5-基 | 1 |
B-5270 | H | H | H | H | H | O | H | H | 哒嗪-3-基 | 1 |
B-5271 | H | H | H | H | H | O | H | H | 4-F-哒嗪-3-基 | 1 |
B-5272 | H | H | H | H | H | O | H | H | 4-Cl-哒嗪-3-基 | 1 |
B-5273 | H | H | H | H | H | O | H | H | 4-Me-哒嗪-3-基 | 1 |
B-5274 | H | H | H | H | H | O | H | H | 4-CF3-哒嗪-3-基 | 1 |
B-5275 | H | H | H | H | H | O | H | H | 4-OMe-哒嗪-3-基 | 1 |
B-5276 | H | H | H | H | H | O | H | H | 哒嗪-4-基 | 1 |
B-5277 | H | H | H | H | H | O | H | H | 3-F-哒嗪-4-基 | 1 |
B-5278 | H | H | H | H | H | O | H | H | 3-Cl-哒嗪-4-基 | 1 |
B-5279 | H | H | H | H | H | O | H | H | 3-Me-哒嗪-4-基 | 1 |
B-5280 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-哒嗪-4-基 | 1 |
[表192]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-5281 | H | H | H | H | H | O | H | H | 3-OMe-哒嗪-4-基 | 1 |
B-5282 | H | H | H | H | H | O | H | H | 5-F-哒嗪-4-基 | 1 |
B-5283 | H | H | H | H | H | O | H | H | 5-Cl-哒嗪-4-基 | 1 |
B-5284 | H | H | H | H | H | O | H | H | 5-Me-哒嗪-4-基 | 1 |
B-5285 | H | H | H | H | H | O | H | H | 5-CF<sub>3</sub>-哒嗪-4-基 | 1 |
B-5286 | H | H | H | H | H | O | H | H | 5-OMe-哒嗪-4-基 | 1 |
B-5287 | H | H | H | H | H | O | H | H | 噻吩-2-基 | 1 |
B-5288 | H | H | H | H | H | O | H | H | 3-F-噻吩-2-基 | 1 |
B-5289 | H | H | H | H | H | O | H | H | 3-Cl-噻吩-2-基 | 1 |
B-5290 | H | H | H | H | H | O | H | H | 3-Me-噻吩-2-基 | 1 |
B-5291 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-噻吩-2-基 | 1 |
B-5292 | H | H | H | H | H | O | H | H | 3-OMe-噻吩-2-基 | 1 |
B-5293 | H | H | H | H | H | O | H | H | 噻吩-3-基 | 1 |
B-5294 | H | H | H | H | H | O | H | H | 2-F-噻吩-3-基 | 1 |
B-5295 | H | H | H | H | H | O | H | H | 2-Cl-噻吩-3-基 | 1 |
B-5296 | H | H | H | H | H | O | H | H | 2-Me-噻吩-3-基 | 1 |
B-5297 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub>-噻吩-3-基 | 1 |
B-5298 | H | H | H | H | H | O | H | H | 2-OMe-噻吩-3-基 | 1 |
B-5299 | H | H | H | H | H | O | H | H | 4-F-噻吩-3-基 | 1 |
B-5300 | H | H | H | H | H | O | H | H | 4-Cl-噻吩-3-基 | 1 |
B-5301 | H | H | H | H | H | O | H | H | 4-Me-噻吩-3-基 | 1 |
B-5302 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-噻吩-3-基 | 1 |
B-5303 | H | H | H | H | H | O | H | H | 4-OMe-噻吩-3-基 | 1 |
B-5304 | H | H | H | H | H | O | H | H | 噻唑-2-基 | 1 |
B-5305 | H | H | H | H | H | O | H | H | 噻唑-4-基 | 1 |
B-5306 | H | H | H | H | H | O | H | H | 5-F-噻唑-4-基 | 1 |
B-5307 | H | H | H | H | H | O | H | H | 5-Me-噻唑-4-基 | 1 |
B-5308 | H | H | H | H | H | O | H | H | 5-CF<sub>3</sub>-噻唑-4-基 | 1 |
B-5309 | H | H | H | H | H | O | H | H | 5-OMe-噻唑-4-基 | 1 |
B-5310 | H | H | H | H | H | O | H | H | 噻唑-5-基 | 1 |
B-5311 | H | H | H | H | H | O | H | H | 4-F-噻唑-5-基 | 1 |
B-5312 | H | H | H | H | H | O | H | H | 4-Me-噻唑-5-基 | 1 |
B-5313 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-噻唑-5-基 | 1 |
B-5314 | H | H | H | H | H | O | H | H | 4-OMe-噻唑-5-基 | 1 |
B-5315 | H | H | H | H | H | O | H | H | 1H-吡咯-1-基 | 1 |
B-5316 | H | H | H | H | H | O | H | H | 2-F-1H-吡咯-1-基 | 1 |
B-5317 | H | H | H | H | H | O | H | H | 2-Me-1H-吡咯-1-基 | 1 |
B-5318 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub>-1H-吡咯-1-基 | 1 |
B-5319 | H | H | H | H | H | O | H | H | 2-OMe-1H-吡咯-1-基 | 1 |
B-5320 | H | H | H | H | H | O | H | H | 1H-吡咯-2-基 | 1 |
B-5321 | H | H | H | H | H | O | H | H | 1-Me-1H-吡咯-2-基 | 1 |
B-5322 | H | H | H | H | H | O | H | H | 3-F-1H-吡咯-2-基 | 1 |
B-5323 | H | H | H | H | H | O | H | H | 3-Me-1H-吡咯-2-基 | 1 |
B-5324 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-1H-吡咯-2-基 | 1 |
B-5325 | H | H | H | H | H | O | H | H | 3-OMe-1H-吡咯-2-基 | 1 |
B-5326 | H | H | H | H | H | O | H | H | 1-Me-3-F-1H-吡咯-2-基 | 1 |
B-5327 | H | H | H | H | H | O | H | H | 1,3-(Me)<sub>2</sub>-1H-吡咯-2-基 | 1 |
B-5328 | H | H | H | H | H | O | H | H | 1-Me-3-CF<sub>3</sub>-1H-吡咯-2-基 | 1 |
B-5329 | H | H | H | H | H | O | H | H | 1-Me-3-OMe-1H-吡咯-2-基 | 1 |
B-5330 | H | H | H | H | H | O | H | H | 1H-吡咯-3-基 | 1 |
B-5331 | H | H | H | H | H | O | H | H | 1-Me-1H-吡咯-3-基 | 1 |
B-5332 | H | H | H | H | H | O | H | H | 2-F-1H-吡咯-3-基 | 1 |
B-5333 | H | H | H | H | H | O | H | H | 2-Me-1H-吡咯-3-基 | 1 |
B-5334 | H | H | H | H | H | O | H | H | 2-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
B-5335 | H | H | H | H | H | O | H | H | 2-OMe-1H-吡咯-3-基 | 1 |
B-5336 | H | H | H | H | H | O | H | H | 1-Me-2-F-1H-吡咯-3-基 | 1 |
B-5337 | H | H | H | H | H | O | H | H | 1,2-(Me)<sub>2</sub>-1H-吡咯-3-基 | 1 |
[表193]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | A | R<sup>6</sup> | R<sup>7</sup> | Q | p |
B-5338 | H | H | H | H | H | O | H | H | 1-Me-2-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
B-5339 | H | H | H | H | H | O | H | H | 1-Me-2-OMe-1H-吡咯-3-基 | 1 |
B-5340 | H | H | H | H | H | O | H | H | 4-F-1H-吡咯-3-基 | 1 |
B-5341 | H | H | H | H | H | O | H | H | 4-Me-1H-吡咯-3-基 | 1 |
B-5342 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
B-5343 | H | H | H | H | H | O | H | H | 4-OMe-1H-吡咯-3-基 | 1 |
B-5344 | H | H | H | H | H | O | H | H | 1-Me-4-F-1H-吡咯-3-基 | 1 |
B-5345 | H | H | H | H | H | O | H | H | 1,4-(Me)<sub>2</sub>-1H-吡咯-3-基 | 1 |
B-5346 | H | H | H | H | H | O | H | H | 1-Me-4-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
B-5347 | H | H | H | H | H | O | H | H | 1-Me-4-OMe-1H-吡咯-3-基 | 1 |
B-5348 | H | H | H | H | H | O | H | H | 1H-吡唑-1-基 | 1 |
B-5349 | H | H | H | H | H | O | H | H | 5-F-1H-吡唑-1-基 | 1 |
B-5350 | H | H | H | H | H | O | H | H | 5-Cl-1H-吡唑-1-基 | 1 |
B-5351 | H | H | H | H | H | O | H | H | 5-Me-1H-吡唑-1-基 | 1 |
B-5352 | H | H | H | H | H | O | H | H | 5-CF<sub>3</sub>-1H-吡唑-1-基 | 1 |
B-5353 | H | H | H | H | H | O | H | H | 5-OMe-1H-吡唑-1-基 | 1 |
B-5354 | H | H | H | H | H | O | H | H | 1H-吡唑-3-基 | 1 |
B-5355 | H | H | H | H | H | O | H | H | 1-Me-1H-吡唑-3-基 | 1 |
B-5356 | H | H | H | H | H | O | H | H | 4-F-1H-吡唑-3-基 | 1 |
B-5357 | H | H | H | H | H | O | H | H | 4-Cl-1H-吡唑-3-基 | 1 |
B-5358 | H | H | H | H | H | O | H | H | 4-Me-1H-吡唑-3-基 | 1 |
B-5359 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-1H-吡唑-3-基 | 1 |
B-5360 | H | H | H | H | H | O | H | H | 4-OMe-1H-吡唑-3-基 | 1 |
B-5361 | H | H | H | H | H | O | H | H | 1-Me-4-F-1H-吡唑-3-基 | 1 |
B-5362 | H | H | H | H | H | O | H | H | 1-Me-4-Cl-1H-吡唑-3-基 | 1 |
B-5363 | H | H | H | H | H | O | H | H | 1,4-(Me)<sub>2</sub>-1H-吡唑-3-基 | 1 |
B-5364 | H | H | H | H | H | O | H | H | 1-Me-4-CF<sub>3</sub>-1H-吡唑-3-基 | 1 |
B-5365 | H | H | H | H | H | O | H | H | 1-Me-4-OMe-1H-吡唑-3-基 | 1 |
B-5366 | H | H | H | H | H | O | H | H | 1H-吡唑-4-基 | 1 |
B-5367 | H | H | H | H | H | O | H | H | 1-Me-1H-吡唑-4-基 | 1 |
B-5368 | H | H | H | H | H | O | H | H | 3-F-1H-吡唑-4-基 | 1 |
B-5369 | H | H | H | H | H | O | H | H | 3-Cl-1H-吡唑-4-基 | 1 |
B-5370 | H | H | H | H | H | O | H | H | 3-Me-1H-吡唑-4-基 | 1 |
B-5371 | H | H | H | H | H | O | H | H | 3-CF<sub>3</sub>-1H-吡唑-4-基 | 1 |
B-5372 | H | H | H | H | H | O | H | H | 3-OMe-1H-吡唑-4-基 | 1 |
B-5373 | H | H | H | H | H | O | H | H | 1-Me-3-F-1H-吡唑-4-基 | 1 |
B-5374 | H | H | H | H | H | O | H | H | 1-Me-3-Cl-1H-吡唑-4-基 | 1 |
B-5375 | H | H | H | H | H | O | H | H | 1,3-(Me)<sub>2</sub>-1H-吡唑-4-基 | 1 |
B-5376 | H | H | H | H | H | O | H | H | 1-Me-3-CF<sub>3</sub>-1H-吡唑-4-基 | 1 |
B-5377 | H | H | H | H | H | O | H | H | 1-Me-3-OMe-1H-吡唑-4-基 | 1 |
B-5378 | H | H | H | H | H | O | H | H | 5-F-1H-吡唑-4-基 | 1 |
B-5379 | H | H | H | H | H | O | H | H | 5-Cl-1H-吡唑-4-基 | 1 |
B-5380 | H | H | H | H | H | O | H | H | 5-Me-1H-吡唑-4-基 | 1 |
B-5381 | H | H | H | H | H | O | H | H | 5-CF<sub>3</sub>-1H-吡唑-4-基 | 1 |
B-5382 | H | H | H | H | H | O | H | H | 5-OMe-1H-吡唑-4-基 | 1 |
B-5383 | H | H | H | H | H | O | H | H | 1-Me-5-F-1H-吡唑-4-基 | 1 |
B-5384 | H | H | H | H | H | O | H | H | 1-Me-5-Cl-1H-吡唑-4-基 | 1 |
B-5385 | H | H | H | H | H | O | H | H | 1,5-(Me)<sub>2</sub>-1H-吡唑-4-基 | 1 |
B-5386 | H | H | H | H | H | O | H | H | 1-Me-5-CF<sub>3</sub>-1H-吡唑-4-基 | 1 |
B-5387 | H | H | H | H | H | O | H | H | 1-Me-5-OMe-1H-吡唑-4-基 | 1 |
B-5388 | H | H | H | H | H | O | H | H | 1H-吡唑-5-基 | 1 |
B-5389 | H | H | H | H | H | O | H | H | 1-Me-1H-吡唑-5-基 | 1 |
B-5390 | H | H | H | H | H | O | H | H | 4-F-1H-吡唑-5-基 | 1 |
B-5391 | H | H | H | H | H | O | H | H | 4-Cl-1H-吡唑-5-基 | 1 |
B-5392 | H | H | H | H | H | O | H | H | 4-Me-1H-吡唑-5-基 | 1 |
B-5393 | H | H | H | H | H | O | H | H | 4-CF<sub>3</sub>-1H-吡唑-5-基 | 1 |
B-5394 | H | H | H | H | H | O | H | H | 4-OMe-1H-吡唑-5-基 | 1 |
[表194]
[表195]
[表196]
[表197]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0052 | H | H | H | H | H | 4-CH<sub>2</sub>F | 0 |
C-0053 | H | H | H | H | H | 2-CF<sub>2</sub>Cl | 0 |
C-0054 | H | H | H | H | H | 3-CF<sub>2</sub>Cl | 0 |
C-0055 | H | H | H | H | H | 4-CF<sub>2</sub>Cl | 0 |
C-0056 | H | H | H | H | H | 2-CF(CF<sub>3</sub>)<sub>2</sub> | 0 |
C-0057 | H | H | H | H | H | 3-CF(CF<sub>3</sub>)<sub>2</sub> | 0 |
C-0058 | H | H | H | H | H | 4-CF(CF<sub>3</sub>)<sub>2</sub> | 0 |
C-0059 | H | H | H | H | H | 2-环丙基 | 0 |
C-0060 | H | H | H | H | H | 3-环丙基 | 0 |
C-0061 | H | H | H | H | H | 4-环丙基 | 0 |
C-0062 | H | H | H | H | H | 2-环丁基 | 0 |
C-0063 | H | H | H | H | H | 3-环丁基 | 0 |
C-0064 | H | H | H | H | H | 4-环丁基 | 0 |
C-0065 | H | H | H | H | H | 2-环戊基 | 0 |
C-0066 | H | H | H | H | H | 3-环戊基 | 0 |
C-0067 | H | H | H | H | H | 4-环戊基 | 0 |
C-0068 | H | H | H | H | H | 2-(环丙基甲基) | 0 |
C-0069 | H | H | H | H | H | 3-(环丙基甲基) | 0 |
C-0070 | H | H | H | H | H | 4-(环丙基甲基) | 0 |
C-0071 | H | H | H | H | H | 2-(环丁基甲基) | 0 |
C-0072 | H | H | H | H | H | 3-(环丁基甲基) | 0 |
C-0073 | H | H | H | H | H | 4-(环丁基甲基) | 0 |
C-0074 | H | H | H | H | H | 2-(环戊基甲基) | 0 |
C-0075 | H | H | H | H | H | 3-(环戊基甲基) | 0 |
C-0076 | H | H | H | H | H | 4-(环戊基甲基) | 0 |
C-0077 | H | H | H | H | H | 2-(环丙基乙基) | 0 |
C-0078 | H | H | H | H | H | 3-(环丙基乙基) | 0 |
C-0079 | H | H | H | H | H | 4-(环丙基乙基) | 0 |
C-0080 | H | H | H | H | H | 2-(2,2-二氟环丙基) | 0 |
C-0081 | H | H | H | H | H | 3-(2,2-二氟环丙基) | 0 |
C-0082 | H | H | H | H | H | 4-(2,2-二氟环丙基) | 0 |
C-0083 | H | H | H | H | H | 2-(2,2-二氯环丙基) | 0 |
C-0084 | H | H | H | H | H | 3-(2,2-二氯环丙基) | 0 |
C-0085 | H | H | H | H | H | 4-(2,2-二氯环丙基) | 0 |
C-0086 | H | H | H | H | H | 2-乙烯基 | 0 |
C-0087 | H | H | H | H | H | 3-乙烯基 | 0 |
C-0088 | H | H | H | H | H | 4-乙烯基 | 0 |
C-0089 | H | H | H | H | H | 2-烯丙基 | 0 |
C-0090 | H | H | H | H | H | 3-烯丙基 | 0 |
C-0091 | H | H | H | H | H | 4-烯丙基 | 0 |
C-0092 | H | H | H | H | H | 2-(丙-1-烯-1-基) | 0 |
C-0093 | H | H | H | H | H | 3-(丙-1-烯-1-基) | 0 |
C-0094 | H | H | H | H | H | 4-(丙-1-烯-1-基) | 0 |
C-0095 | H | H | H | H | H | 2-(三氟乙烯基) | 0 |
C-0096 | H | H | H | H | H | 3-(三氟乙烯基) | 0 |
C-0097 | H | H | H | H | H | 4-(三氟乙烯基) | 0 |
C-0098 | H | H | H | H | H | 2-(2,2-二氯乙烯基) | 0 |
C-0099 | H | H | H | H | H | 3-(2,2-二氯乙烯基) | 0 |
C-0100 | H | H | H | H | H | 4-(2,2-二氯乙烯基) | 0 |
C-0101 | H | H | H | H | H | 2-乙炔基 | 0 |
C-0102 | H | H | H | H | H | 3-乙炔基 | 0 |
C-0103 | H | H | H | H | H | 4-乙炔基 | 0 |
C-0104 | H | H | H | H | H | 2-(1-丙炔-1-基) | 0 |
C-0105 | H | H | H | H | H | 3-(1-丙炔-1-基) | 0 |
C-0106 | H | H | H | H | H | 4-(1-丙炔-1-基) | 0 |
C-0107 | H | H | H | H | H | 2-(2-丙炔-1-基) | 0 |
[表198]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0108 | H | H | H | H | H | 3-(2-丙炔-1-基) | 0 |
C-0109 | H | H | H | H | H | 4-(2-丙炔-1-基) | 0 |
C-0110 | H | H | H | H | H | 2-(2-环丙基乙炔基) | 0 |
C-0111 | H | H | H | H | H | 3-(2-环丙基乙炔基) | 0 |
C-0112 | H | H | H | H | H | 4-(2-环丙基乙炔基) | 0 |
C-0113 | H | H | H | H | H | 2-(2-氯乙炔基) | 0 |
C-0114 | H | H | H | H | H | 3-(2-氯乙炔基) | 0 |
C-0115 | H | H | H | H | H | 4-(2-氯乙炔基) | 0 |
C-0116 | H | H | H | H | H | 2-(2-溴乙炔基) | 0 |
C-0117 | H | H | H | H | H | 3-(2-溴乙炔基) | 0 |
C-0118 | H | H | H | H | H | 4-(2-溴乙炔基) | 0 |
C-0119 | H | H | H | H | H | 2-OMe | 0 |
C-0120 | H | H | H | H | H | 3-OMe | 0 |
C-0121 | H | H | H | H | H | 4-OMe | 0 |
C-0122 | H | H | H | H | H | 2-OEt | 0 |
C-0123 | H | H | H | H | H | 3-OEt | 0 |
C-0124 | H | H | H | H | H | 4-OEt | 0 |
C-0125 | H | H | H | H | H | 2-OPr | 0 |
C-0126 | H | H | H | H | H | 3-OPr | 0 |
C-0127 | H | H | H | H | H | 4-OPr | 0 |
C-0128 | H | H | H | H | H | 2-O(i-Pr) | 0 |
C-0129 | H | H | H | H | H | 3-O(i-Pr) | 0 |
C-0130 | H | H | H | H | H | 4-O(i-Pr) | 0 |
C-0131 | H | H | H | H | H | 2-OBu | 0 |
C-0132 | H | H | H | H | H | 3-OBu | 0 |
C-0133 | H | H | H | H | H | 4-OBu | 0 |
C-0134 | H | H | H | H | H | 2-O(s-Bu) | 0 |
C-0135 | H | H | H | H | H | 3-O(s-Bu) | 0 |
C-0136 | H | H | H | H | H | 4-O(s-Bu) | 0 |
C-0137 | H | H | H | H | H | 2-O(i-Bu) | 0 |
C-0138 | H | H | H | H | H | 3-O(i-Bu) | 0 |
C-0139 | H | H | H | H | H | 4-O(i-Bu) | 0 |
C-0140 | H | H | H | H | H | 2-O(t-Bu) | 0 |
C-0141 | H | H | H | H | H | 3-O(t-Bu) | 0 |
C-0142 | H | H | H | H | H | 4-O(t-Bu) | 0 |
C-0143 | H | H | H | H | H | 2-OCF<sub>3</sub> | 0 |
C-0144 | H | H | H | H | H | 3-OCF<sub>3</sub> | 0 |
C-0145 | H | H | H | H | H | 4-OCF<sub>3</sub> | 0 |
C-0146 | H | H | H | H | H | 2-OCHF<sub>2</sub> | 0 |
C-0147 | H | H | H | H | H | 3-OCHF<sub>2</sub> | 0 |
C-0148 | H | H | H | H | H | 4-OCHF<sub>2</sub> | 0 |
C-0149 | H | H | H | H | H | 2-OCH<sub>2</sub>CF<sub>3</sub> | 0 |
C-0150 | H | H | H | H | H | 3-OCH<sub>2</sub>CF<sub>3</sub> | 0 |
C-0151 | H | H | H | H | H | 4-OCH<sub>2</sub>CF<sub>3</sub> | 0 |
C-0152 | H | H | H | H | H | 2-(环丙基氧基) | 0 |
C-0153 | H | H | H | H | H | 3-(环丙基氧基) | 0 |
C-0154 | H | H | H | H | H | 4-(环丙基氧基) | 0 |
C-0155 | H | H | H | H | H | 2-(环丁基氧基) | 0 |
C-0156 | H | H | H | H | H | 3-(环丁基氧基) | 0 |
C-0157 | H | H | H | H | H | 4-(环丁基氧基) | 0 |
C-0158 | H | H | H | H | H | 2-(环戊基氧基) | 0 |
C-0159 | H | H | H | H | H | 3-(环戊基氧基) | 0 |
C-0160 | H | H | H | H | H | 4-(环戊基氧基) | 0 |
C-0161 | H | H | H | H | H | 2-((2,2-二氯环丙基)氧基) | 0 |
C-0162 | H | H | H | H | H | 3-((2,2-二氯环丙基)氧基) | 0 |
C-0163 | H | H | H | H | H | 4-((2,2-二氯环丙基)氧基) | 0 |
[表199]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0164 | H | H | H | H | H | 2-(环丙基甲氧基) | 0 |
C-0165 | H | H | H | H | H | 3-(环丙基甲氧基) | 0 |
C-0166 | H | H | H | H | H | 4-(环丙基甲氧基) | 0 |
C-0167 | H | H | H | H | H | 2-((2,2-二氟环丙基)甲氧基) | 0 |
C-0168 | H | H | H | H | H | 3-((2,2-二氟环丙基)甲氧基) | 0 |
C-0169 | H | H | H | H | H | 4-((2,2-二氟环丙基)甲氧基) | 0 |
C-0170 | H | H | H | H | H | 2-(环氧乙烷-2-基) | 0 |
C-0171 | H | H | H | H | H | 3-(环氧乙烷-2-基) | 0 |
C-0172 | H | H | H | H | H | 4-(环氧乙烷-2-基) | 0 |
C-0173 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基) | 0 |
C-0174 | H | H | H | H | H | 3-(环氧乙烷-2-基甲基) | 0 |
C-0175 | H | H | H | H | H | 4-(环氧乙烷-2-基甲基) | 0 |
C-0176 | H | H | H | H | H | 2-SMe | 0 |
C-0177 | H | H | H | H | H | 3-SMe | 0 |
C-0178 | H | H | H | H | H | 4-SMe | 0 |
C-0179 | H | H | H | H | H | 2-SEt | 0 |
C-0180 | H | H | H | H | H | 3-SEt | 0 |
C-0181 | H | H | H | H | H | 4-SEt | 0 |
C-0182 | H | H | H | H | H | 2-S(=O)Me | 0 |
C-0183 | H | H | H | H | H | 3-S(=O)Me | 0 |
C-0184 | H | H | H | H | H | 4-S(=O)Me | 0 |
C-0185 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me | 0 |
C-0186 | H | H | H | H | H | 3-S(=O)<sub>2</sub>Me | 0 |
C-0187 | H | H | H | H | H | 4-S(=O)<sub>2</sub>Me | 0 |
C-0188 | H | H | H | H | H | 2-SCF<sub>3</sub> | 0 |
C-0189 | H | H | H | H | H | 3-SCF<sub>3</sub> | 0 |
C-0190 | H | H | H | H | H | 4-SCF<sub>3</sub> | 0 |
C-0191 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub> | 0 |
C-0192 | H | H | H | H | H | 3-S(=O)CF<sub>3</sub> | 0 |
C-0193 | H | H | H | H | H | 4-S(=O)CF<sub>3</sub> | 0 |
C-0194 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
C-0195 | H | H | H | H | H | 3-S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
C-0196 | H | H | H | H | H | 4-S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
C-0197 | H | H | H | H | H | 2-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
C-0198 | H | H | H | H | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
C-0199 | H | H | H | H | H | 4-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
C-0200 | H | H | H | H | H | 2-(环丙基硫基) | 0 |
C-0201 | H | H | H | H | H | 3-(环丙基硫基) | 0 |
C-0202 | H | H | H | H | H | 4-(环丙基硫基) | 0 |
C-0203 | H | H | H | H | H | 2-(环丙基亚磺酰基) | 0 |
C-0204 | H | H | H | H | H | 3-(环丙基亚磺酰基) | 0 |
C-0205 | H | H | H | H | H | 4-(环丙基亚磺酰基) | 0 |
C-0206 | H | H | H | H | H | 2-(环丙基磺酰基) | 0 |
C-0207 | H | H | H | H | H | 3-(环丙基磺酰基) | 0 |
C-0208 | H | H | H | H | H | 4-(环丙基磺酰基) | 0 |
C-0209 | H | H | H | H | H | 2-((环丙基甲基)硫基) | 0 |
C-0210 | H | H | H | H | H | 3-((环丙基甲基)硫基) | 0 |
C-0211 | H | H | H | H | H | 4-((环丙基甲基)硫基) | 0 |
C-0212 | H | H | H | H | H | 2-((环丙基甲基)亚磺酰基) | 0 |
C-0213 | H | H | H | H | H | 3-((环丙基甲基)亚磺酰基) | 0 |
C-0214 | H | H | H | H | H | 4-((环丙基甲基)亚磺酰基) | 0 |
C-0215 | H | H | H | H | H | 2-((环丙基甲基)磺酰基) | 0 |
C-0216 | H | H | H | H | H | 3-((环丙基甲基)磺酰基) | 0 |
C-0217 | H | H | H | H | H | 4-((环丙基甲基)磺酰基) | 0 |
C-0218 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)硫基) | 0 |
C-0219 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)硫基) | 0 |
[表200]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0220 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)硫基) | 0 |
C-0221 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)亚磺酰基) | 0 |
C-0222 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)亚磺酰基) | 0 |
C-0223 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)亚磺酰基) | 0 |
C-0224 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)磺酰基) | 0 |
C-0225 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)磺酰基) | 0 |
C-0226 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)磺酰基) | 0 |
C-0227 | H | H | H | H | H | 2-C(=O)Me | 0 |
C-0228 | H | H | H | H | H | 3-C(=O)Me | 0 |
C-0229 | H | H | H | H | H | 4-C(=O)Me | 0 |
C-0230 | H | H | H | H | H | 2-C(=O)Et | 0 |
C-0231 | H | H | H | H | H | 3-C(=O)Et | 0 |
C-0232 | H | H | H | H | H | 4-C(=O)Et | 0 |
C-0233 | H | H | H | H | H | 2-C(=O)CF<sub>3</sub> | 0 |
C-0234 | H | H | H | H | H | 3-C(=O)CF<sub>3</sub> | 0 |
C-0235 | H | H | H | H | H | 4-C(=O)CF<sub>3</sub> | 0 |
C-0236 | H | H | H | H | H | 2-C(=O)OMe | 0 |
C-0237 | H | H | H | H | H | 3-C(=O)OMe | 0 |
C-0238 | H | H | H | H | H | 4-C(=O)OMe | 0 |
C-0239 | H | H | H | H | H | 2-C(=O)OEt | 0 |
C-0240 | H | H | H | H | H | 3-C(=O)OEt | 0 |
C-0241 | H | H | H | H | H | 4-C(=O)OEt | 0 |
C-0242 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub> | 0 |
C-0243 | H | H | H | H | H | 3-C(=O)NH<sub>2</sub> | 0 |
C-0244 | H | H | H | H | H | 4-C(=O)NH<sub>2</sub> | 0 |
C-0245 | H | H | H | H | H | 2-C(=O)NHMe | 0 |
C-0246 | H | H | H | H | H | 3-C(=O)NHMe | 0 |
C-0247 | H | H | H | H | H | 4-C(=O)NHMe | 0 |
C-0248 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub> | 0 |
C-0249 | H | H | H | H | H | 3-C(=O)NMe<sub>2</sub> | 0 |
C-0250 | H | H | H | H | H | 4-C(=O)NMe<sub>2</sub> | 0 |
C-0251 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
C-0252 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
C-0253 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
C-0254 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
C-0255 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
C-0256 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
C-0257 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 0 |
C-0258 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 0 |
C-0259 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 0 |
C-0260 | H | H | H | H | H | 2-CH<sub>2</sub>OH | 0 |
C-0261 | H | H | H | H | H | 3-CH<sub>2</sub>OH | 0 |
C-0262 | H | H | H | H | H | 4-CH<sub>2</sub>OH | 0 |
C-0263 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
C-0264 | H | H | H | H | H | 3-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
C-0265 | H | H | H | H | H | 4-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
C-0266 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
C-0267 | H | H | H | H | H | 3-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
C-0268 | H | H | H | H | H | 4-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
C-0269 | H | H | H | H | H | 2-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 0 |
C-0270 | H | H | H | H | H | 3-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 0 |
C-0271 | H | H | H | H | H | 4-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 0 |
C-0272 | H | H | H | H | H | 2-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 0 |
C-0273 | H | H | H | H | H | 3-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 0 |
C-0274 | H | H | H | H | H | 4-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 0 |
C-0275 | H | H | H | H | H | 2-CH<sub>2</sub>OCF<sub>3</sub> | 0 |
[表201]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0276 | H | H | H | H | H | 3-CH<sub>2</sub>OCF<sub>3</sub> | 0 |
C-0277 | H | H | H | H | H | 4-CH<sub>2</sub>OCF<sub>3</sub> | 0 |
C-0278 | H | H | H | H | H | 2-CF<sub>2</sub>OCH<sub>3</sub> | 0 |
C-0279 | H | H | H | H | H | 3-CF<sub>2</sub>OCH<sub>3</sub> | 0 |
C-0280 | H | H | H | H | H | 4-CF<sub>2</sub>OCH<sub>3</sub> | 0 |
C-0281 | H | H | H | H | H | 2-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 0 |
C-0282 | H | H | H | H | H | 3-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 0 |
C-0283 | H | H | H | H | H | 4-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 0 |
C-0284 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub> | 0 |
C-0285 | H | H | H | H | H | 3-OC(=O)CH<sub>3</sub> | 0 |
C-0286 | H | H | H | H | H | 4-OC(=O)CH<sub>3</sub> | 0 |
C-0287 | H | H | H | H | H | 2-OC(=O)CF<sub>3</sub> | 0 |
C-0288 | H | H | H | H | H | 3-OC(=O)CF<sub>3</sub> | 0 |
C-0289 | H | H | H | H | H | 4-OC(=O)CF<sub>3</sub> | 0 |
C-0290 | H | H | H | H | H | 2-OC(=O)NH<sub>2</sub> | 0 |
C-0291 | H | H | H | H | H | 3-OC(=O)NH<sub>2</sub> | 0 |
C-0292 | H | H | H | H | H | 4-OC(=O)NH<sub>2</sub> | 0 |
C-0293 | H | H | H | H | H | 2-OC(=O)NHCH<sub>3</sub> | 0 |
C-0294 | H | H | H | H | H | 3-OC(=O)NHCH<sub>3</sub> | 0 |
C-0295 | H | H | H | H | H | 4-OC(=O)NHCH<sub>3</sub> | 0 |
C-0296 | H | H | H | H | H | 2-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
C-0297 | H | H | H | H | H | 3-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
C-0298 | H | H | H | H | H | 4-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
C-0299 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 0 |
C-0300 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 0 |
C-0301 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 0 |
C-0302 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 0 |
C-0303 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 0 |
C-0304 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 0 |
C-0305 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
C-0306 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
C-0307 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
C-0308 | H | H | H | H | H | 2-OC(=O)OCH<sub>3</sub> | 0 |
C-0309 | H | H | H | H | H | 3-OC(=O)OCH<sub>3</sub> | 0 |
C-0310 | H | H | H | H | H | 4-OC(=O)OCH<sub>3</sub> | 0 |
C-0311 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 0 |
C-0312 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 0 |
C-0313 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 0 |
C-0314 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 0 |
C-0315 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 0 |
C-0316 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 0 |
C-0317 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
C-0318 | H | H | H | H | H | 3-OS(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
C-0319 | H | H | H | H | H | 4-OS(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
C-0320 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
C-0321 | H | H | H | H | H | 3-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
C-0322 | H | H | H | H | H | 4-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
C-0323 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
C-0324 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
C-0325 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
C-0326 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
C-0327 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
C-0328 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
C-0329 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub> | 0 |
C-0330 | H | H | H | H | H | 3-CH<sub>2</sub>SCF<sub>3</sub> | 0 |
C-0331 | H | H | H | H | H | 4-CH<sub>2</sub>SCF<sub>3</sub> | 0 |
[表202]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0332 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 0 |
C-0333 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 0 |
C-0334 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 0 |
C-0335 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
C-0336 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
C-0337 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
C-0338 | H | H | H | H | H | 2-苯基 | 0 |
C-0339 | H | H | H | H | H | 3-苯基 | 0 |
C-0340 | H | H | H | H | H | 4-苯基 | 0 |
C-0341 | H | H | H | H | H | 2-(苯氧基) | 0 |
C-0342 | H | H | H | H | H | 3-(苯氧基) | 0 |
C-0343 | H | H | H | H | H | 4-(苯氧基) | 0 |
C-0344 | H | H | H | H | H | 2-苯甲基 | 0 |
C-0345 | H | H | H | H | H | 3-苯甲基 | 0 |
C-0346 | H | H | H | H | H | 4-苯甲基 | 0 |
C-0347 | H | H | H | H | H | 2-(苯甲基氧基) | 0 |
C-0348 | H | H | H | H | H | 3-(苯甲基氧基) | 0 |
C-0349 | H | H | H | H | H | 4-(苯甲基氧基) | 0 |
C-0350 | H | H | H | H | H | 2-((2-氟苯甲基)氧基) | 0 |
C-0351 | H | H | H | H | H | 3-((2-氟苯甲基)氧基) | 0 |
C-0352 | H | H | H | H | H | 4-((2-氟苯甲基)氧基) | 0 |
C-0353 | H | H | H | H | H | 2-((3-氟苯甲基)氧基) | 0 |
C-0354 | H | H | H | H | H | 3-((3-氟苯甲基)氧基) | 0 |
C-0355 | H | H | H | H | H | 4-((3-氟苯甲基)氧基) | 0 |
C-0356 | H | H | H | H | H | 2-((4-氟苯甲基)氧基) | 0 |
C-0357 | H | H | H | H | H | 3-((4-氟苯甲基)氧基) | 0 |
C-0358 | H | H | H | H | H | 4-((4-氟苯甲基)氧基) | 0 |
C-0359 | H | H | H | H | H | 2-((2-氯苯甲基)氧基) | 0 |
C-0360 | H | H | H | H | H | 3-((2-氯苯甲基)氧基) | 0 |
C-0361 | H | H | H | H | H | 4-((2-氯苯甲基)氧基) | 0 |
C-0362 | H | H | H | H | H | 2-((3-氯苯甲基)氧基) | 0 |
C-0363 | H | H | H | H | H | 3-((3-氯苯甲基)氧基) | 0 |
C-0364 | H | H | H | H | H | 4-((3-氯苯甲基)氧基) | 0 |
C-0365 | H | H | H | H | H | 2-((4-氯苯甲基)氧基) | 0 |
C-0366 | H | H | H | H | H | 3-((4-氯苯甲基)氧基) | 0 |
C-0367 | H | H | H | H | H | 4-((4-氯苯甲基)氧基) | 0 |
C-0368 | H | H | H | H | H | 2-((2-甲基苯甲基)氧基) | 0 |
C-0369 | H | H | H | H | H | 3-((2-甲基苯甲基)氧基) | 0 |
C-0370 | H | H | H | H | H | 4-((2-甲基苯甲基)氧基) | 0 |
C-0371 | H | H | H | H | H | 2-((3-甲基苯甲基)氧基) | 0 |
C-0372 | H | H | H | H | H | 3-((3-甲基苯甲基)氧基) | 0 |
C-0373 | H | H | H | H | H | 4-((3-甲基苯甲基)氧基) | 0 |
C-0374 | H | H | H | H | H | 2-((4-甲基苯甲基)氧基) | 0 |
C-0375 | H | H | H | H | H | 3-((4-甲基苯甲基)氧基) | 0 |
C-0376 | H | H | H | H | H | 4-((4-甲基苯甲基)氧基) | 0 |
C-0377 | H | H | H | H | H | 2-((2-(三氟甲基)苯甲基)氧基) | 0 |
C-0378 | H | H | H | H | H | 3-((2-(三氟甲基)苯甲基)氧基) | 0 |
C-0379 | H | H | H | H | H | 4-((2-(三氟甲基)苯甲基)氧基) | 0 |
C-0380 | H | H | H | H | H | 2-((3-(三氟甲基)苯甲基)氧基) | 0 |
C-0381 | H | H | H | H | H | 3-((3-(三氟甲基)苯甲基)氧基) | 0 |
C-0382 | H | H | H | H | H | 4-((3-(三氟甲基)苯甲基)氧基) | 0 |
C-0383 | H | H | H | H | H | 2-((4-(三氟甲基)苯甲基)氧基) | 0 |
C-0384 | H | H | H | H | H | 3-((4-(三氟甲基)苯甲基)氧基) | 0 |
C-0385 | H | H | H | H | H | 4-((4-(三氟甲基)苯甲基)氧基) | 0 |
C-0386 | H | H | H | H | H | 2-((2-甲氧基苯甲基)氧基) | 0 |
C-0387 | H | H | H | H | H | 3-((2-甲氧基苯甲基)氧基) | 0 |
[表203]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0388 | H | H | H | H | H | 4-((2-甲氧基苯甲基)氧基) | 0 |
C-0389 | H | H | H | H | H | 2-((3-甲氧基苯甲基)氧基) | 0 |
C-0390 | H | H | H | H | H | 3-((3-甲氧基苯甲基)氧基) | 0 |
C-0391 | H | H | H | H | H | 4-((3-甲氧基苯甲基)氧基) | 0 |
C-0392 | H | H | H | H | H | 2-((4-甲氧基苯甲基)氧基) | 0 |
C-0393 | H | H | H | H | H | 3-((4-甲氧基苯甲基)氧基) | 0 |
C-0394 | H | H | H | H | H | 4-((4-甲氧基苯甲基)氧基) | 0 |
C-0395 | H | H | H | H | H | 2-((2-(三氟甲氧基)苯甲基)氧基) | 0 |
C-0396 | H | H | H | H | H | 3-((2-(三氟甲氧基)苯甲基)氧基) | 0 |
C-0397 | H | H | H | H | H | 4-((2-(三氟甲氧基)苯甲基)氧基) | 0 |
C-0398 | H | H | H | H | H | 2-((3-(三氟甲氧基)苯甲基)氧基) | 0 |
C-0399 | H | H | H | H | H | 3-((3-(三氟甲氧基)苯甲基)氧基) | 0 |
C-0400 | H | H | H | H | H | 4-((3-(三氟甲氧基)苯甲基)氧基) | 0 |
C-0401 | H | H | H | H | H | 2-((4-(三氟甲氧基)苯甲基)氧基) | 0 |
C-0402 | H | H | H | H | H | 3-((4-(三氟甲氧基)苯甲基)氧基) | 0 |
C-0403 | H | H | H | H | H | 4-((4-(三氟甲氧基)苯甲基)氧基) | 0 |
C-0404 | H | H | H | H | H | 2-((2-(甲基硫基)苯甲基)氧基) | 0 |
C-0405 | H | H | H | H | H | 3-((2-(甲基硫基)苯甲基)氧基) | 0 |
C-0406 | H | H | H | H | H | 4-((2-(甲基硫基)苯甲基)氧基) | 0 |
C-0407 | H | H | H | H | H | 2-((3-(甲基硫基)苯甲基)氧基) | 0 |
C-0408 | H | H | H | H | H | 3-((3-(甲基硫基)苯甲基)氧基) | 0 |
C-0409 | H | H | H | H | H | 4-((3-(甲基硫基)苯甲基)氧基) | 0 |
C-0410 | H | H | H | H | H | 2-((4-(甲基硫基)苯甲基)氧基) | 0 |
C-0411 | H | H | H | H | H | 3-((4-(甲基硫基)苯甲基)氧基) | 0 |
C-0412 | H | H | H | H | H | 4-((4-(甲基硫基)苯甲基)氧基) | 0 |
C-0413 | H | H | H | H | H | 2-((2-(甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0414 | H | H | H | H | H | 3-((2-(甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0415 | H | H | H | H | H | 4-((2-(甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0416 | H | H | H | H | H | 2-((3-(甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0417 | H | H | H | H | H | 3-((3-(甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0418 | H | H | H | H | H | 4-((3-(甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0419 | H | H | H | H | H | 2-((4-(甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0420 | H | H | H | H | H | 3-((4-(甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0421 | H | H | H | H | H | 4-((4-(甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0422 | H | H | H | H | H | 2-((2-(甲基磺酰基)苯甲基)氧基) | 0 |
C-0423 | H | H | H | H | H | 3-((2-(甲基磺酰基)苯甲基)氧基) | 0 |
C-0424 | H | H | H | H | H | 4-((2-(甲基磺酰基)苯甲基)氧基) | 0 |
C-0425 | H | H | H | H | H | 2-((3-(甲基磺酰基)苯甲基)氧基) | 0 |
C-0426 | H | H | H | H | H | 3-((3-(甲基磺酰基)苯甲基)氧基) | 0 |
C-0427 | H | H | H | H | H | 4-((3-(甲基磺酰基)苯甲基)氧基) | 0 |
C-0428 | H | H | H | H | H | 2-((4-(甲基磺酰基)苯甲基)氧基) | 0 |
C-0429 | H | H | H | H | H | 3-((4-(甲基磺酰基)苯甲基)氧基) | 0 |
C-0430 | H | H | H | H | H | 4-((4-(甲基磺酰基)苯甲基)氧基) | 0 |
C-0431 | H | H | H | H | H | 2-((2-(三氟甲基硫基)苯甲基)氧基) | 0 |
C-0432 | H | H | H | H | H | 3-((2-(三氟甲基硫基)苯甲基)氧基) | 0 |
C-0433 | H | H | H | H | H | 4-((2-(三氟甲基硫基)苯甲基)氧基) | 0 |
C-0434 | H | H | H | H | H | 2-((3-(三氟甲基硫基)苯甲基)氧基) | 0 |
C-0435 | H | H | H | H | H | 3-((3-(三氟甲基硫基)苯甲基)氧基) | 0 |
C-0436 | H | H | H | H | H | 4-((3-(三氟甲基硫基)苯甲基)氧基) | 0 |
C-0437 | H | H | H | H | H | 2-((4-(三氟甲基硫基)苯甲基)氧基) | 0 |
C-0438 | H | H | H | H | H | 3-((4-(三氟甲基硫基)苯甲基)氧基) | 0 |
C-0439 | H | H | H | H | H | 4-((4-(三氟甲基硫基)苯甲基)氧基) | 0 |
C-0440 | H | H | H | H | H | 2-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0441 | H | H | H | H | H | 3-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0442 | H | H | H | H | H | 4-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0443 | H | H | H | H | H | 2-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
[表204]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0444 | H | H | H | H | H | 3-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0445 | H | H | H | H | H | 4-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0446 | H | H | H | H | H | 2-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0447 | H | H | H | H | H | 3-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0448 | H | H | H | H | H | 4-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
C-0449 | H | H | H | H | H | 2-((2-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
C-0450 | H | H | H | H | H | 3-((2-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
C-0451 | H | H | H | H | H | 4-((2-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
C-0452 | H | H | H | H | H | 2-((3-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
C-0453 | H | H | H | H | H | 3-((3-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
C-0454 | H | H | H | H | H | 4-((3-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
C-0455 | H | H | H | H | H | 2-((4-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
C-0456 | H | H | H | H | H | 3-((4-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
C-0457 | H | H | H | H | H | 4-((4-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
C-0458 | H | H | H | H | H | 2-((2-氨基苯甲基)氧基) | 0 |
C-0459 | H | H | H | H | H | 3-((2-氨基苯甲基)氧基) | 0 |
C-0460 | H | H | H | H | H | 4-((2-氨基苯甲基)氧基) | 0 |
C-0461 | H | H | H | H | H | 2-((3-氨基苯甲基)氧基) | 0 |
C-0462 | H | H | H | H | H | 3-((3-氨基苯甲基)氧基) | 0 |
C-0463 | H | H | H | H | H | 4-((3-氨基苯甲基)氧基) | 0 |
C-0464 | H | H | H | H | H | 2-((4-氨基苯甲基)氧基) | 0 |
C-0465 | H | H | H | H | H | 3-((4-氨基苯甲基)氧基) | 0 |
C-0466 | H | H | H | H | H | 4-((4-氨基苯甲基)氧基) | 0 |
C-0467 | H | H | H | H | H | 2-((2-(甲基氨基)苯甲基)氧基) | 0 |
C-0468 | H | H | H | H | H | 3-((2-(甲基氨基)苯甲基)氧基) | 0 |
C-0469 | H | H | H | H | H | 4-((2-(甲基氨基)苯甲基)氧基) | 0 |
C-0470 | H | H | H | H | H | 2-((3-(甲基氨基)苯甲基)氧基) | 0 |
C-0471 | H | H | H | H | H | 3-((3-(甲基氨基)苯甲基)氧基) | 0 |
C-0472 | H | H | H | H | H | 4-((3-(甲基氨基)苯甲基)氧基) | 0 |
C-0473 | H | H | H | H | H | 2-((4-(甲基氨基)苯甲基)氧基) | 0 |
C-0474 | H | H | H | H | H | 3-((4-(甲基氨基)苯甲基)氧基) | 0 |
C-0475 | H | H | H | H | H | 4-((4-(甲基氨基)苯甲基)氧基) | 0 |
C-0476 | H | H | H | H | H | 2-((2-(二甲基氨基)苯甲基)氧基) | 0 |
C-0477 | H | H | H | H | H | 3-((2-(二甲基氨基)苯甲基)氧基) | 0 |
C-0478 | H | H | H | H | H | 4-((2-(二甲基氨基)苯甲基)氧基) | 0 |
C-0479 | H | H | H | H | H | 2-((3-(二甲基氨基)苯甲基)氧基) | 0 |
C-0480 | H | H | H | H | H | 3-((3-(二甲基氨基)苯甲基)氧基) | 0 |
C-0481 | H | H | H | H | H | 4-((3-(二甲基氨基)苯甲基)氧基) | 0 |
C-0482 | H | H | H | H | H | 2-((4-(二甲基氨基)苯甲基)氧基) | 0 |
C-0483 | H | H | H | H | H | 3-((4-(二甲基氨基)苯甲基)氧基) | 0 |
C-0484 | H | H | H | H | H | 4-((4-(二甲基氨基)苯甲基)氧基) | 0 |
C-0485 | H | H | H | H | H | 2-((2-氰基苯甲基)氧基) | 0 |
C-0486 | H | H | H | H | H | 3-((2-氰基苯甲基)氧基) | 0 |
C-0487 | H | H | H | H | H | 4-((2-氰基苯甲基)氧基) | 0 |
C-0488 | H | H | H | H | H | 2-((3-氰基苯甲基)氧基) | 0 |
C-0489 | H | H | H | H | H | 3-((3-氰基苯甲基)氧基) | 0 |
C-0490 | H | H | H | H | H | 4-((3-氰基苯甲基)氧基) | 0 |
C-0491 | H | H | H | H | H | 2-((4-氰基苯甲基)氧基) | 0 |
C-0492 | H | H | H | H | H | 3-((4-氰基苯甲基)氧基) | 0 |
C-0493 | H | H | H | H | H | 4-((4-氰基苯甲基)氧基) | 0 |
C-0494 | H | H | H | H | H | 2-((2-硝基苯甲基)氧基) | 0 |
C-0495 | H | H | H | H | H | 3-((2-硝基苯甲基)氧基) | 0 |
C-0496 | H | H | H | H | H | 4-((2-硝基苯甲基)氧基) | 0 |
C-0497 | H | H | H | H | H | 2-((3-硝基苯甲基)氧基) | 0 |
C-0498 | H | H | H | H | H | 3-((3-硝基苯甲基)氧基) | 0 |
C-0499 | H | H | H | H | H | 4-((3-硝基苯甲基)氧基) | 0 |
[表205]
[表206]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0556 | H | H | H | H | H | 2,5-F<sub>2</sub> | 0 |
C-0557 | H | H | H | H | H | 2,6-F<sub>2</sub> | 0 |
C-0558 | H | H | H | H | H | 3,4-F<sub>2</sub> | 0 |
C-0559 | H | H | H | H | H | 3,5-F<sub>2</sub> | 0 |
C-0560 | H | H | H | H | H | 2-F,3-Cl | 0 |
C-0561 | H | H | H | H | H | 2-F,4-Cl | 0 |
C-0562 | H | H | H | H | H | 2-F,5-Cl | 0 |
C-0563 | H | H | H | H | H | 2-F,6-Cl | 0 |
C-0564 | H | H | H | H | H | 3-F,2-Cl | 0 |
C-0565 | H | H | H | H | H | 3-F,4-Cl | 0 |
C-0566 | H | H | H | H | H | 3-F,5-Cl | 0 |
C-0567 | H | H | H | H | H | 3-F,6-Cl | 0 |
C-0568 | H | H | H | H | H | 4-F,2-Cl | 0 |
C-0569 | H | H | H | H | H | 4-F,3-Cl | 0 |
C-0570 | H | H | H | H | H | 2-F,3-Me | 0 |
C-0571 | H | H | H | H | H | 2-F,4-Me | 0 |
C-0572 | H | H | H | H | H | 2-F,5-Me | 0 |
C-0573 | H | H | H | H | H | 2-F,6-Me | 0 |
C-0574 | H | H | H | H | H | 3-F,2-Me | 0 |
C-0575 | H | H | H | H | H | 3-F,4-Me | 0 |
C-0576 | H | H | H | H | H | 3-F,5-Me | 0 |
C-0577 | H | H | H | H | H | 3-F,6-Me | 0 |
C-0578 | H | H | H | H | H | 4-F,2-Me | 0 |
C-0579 | H | H | H | H | H | 4-F,3-Me | 0 |
C-0580 | H | H | H | H | H | 2-F,3-CF<sub>3</sub> | 0 |
C-0581 | H | H | H | H | H | 2-F,4-CF<sub>3</sub> | 0 |
C-0582 | H | H | H | H | H | 2-F,5-CF<sub>3</sub> | 0 |
C-0583 | H | H | H | H | H | 2-F,6-CF<sub>3</sub> | 0 |
C-0584 | H | H | H | H | H | 3-F,2-CF<sub>3</sub> | 0 |
C-0585 | H | H | H | H | H | 3-F,4-CF<sub>3</sub> | 0 |
C-0586 | H | H | H | H | H | 3-F,5-CF<sub>3</sub> | 0 |
C-0587 | H | H | H | H | H | 3-F,6-CF<sub>3</sub> | 0 |
C-0588 | H | H | H | H | H | 4-F,2-CF<sub>3</sub> | 0 |
C-0589 | H | H | H | H | H | 4-F,3-CF<sub>3</sub> | 0 |
C-0590 | H | H | H | H | H | 2-F,3-OMe | 0 |
C-0591 | H | H | H | H | H | 2-F,4-OMe | 0 |
C-0592 | H | H | H | H | H | 2-F,5-OMe | 0 |
C-0593 | H | H | H | H | H | 2-F,6-OMe | 0 |
C-0594 | H | H | H | H | H | 3-F,2-OMe | 0 |
C-0595 | H | H | H | H | H | 3-F,4-OMe | 0 |
C-0596 | H | H | H | H | H | 3-F,5-OMe | 0 |
C-0597 | H | H | H | H | H | 3-F,6-OMe | 0 |
C-0598 | H | H | H | H | H | 4-F,2-OMe | 0 |
C-0599 | H | H | H | H | H | 4-F,3-OMe | 0 |
C-0600 | H | H | H | H | H | 2,3-Cl<sub>2</sub> | 0 |
C-0601 | H | H | H | H | H | 2,4-Cl<sub>2</sub> | 0 |
C-0602 | H | H | H | H | H | 2,5-Cl<sub>2</sub> | 0 |
C-0603 | H | H | H | H | H | 2,6-Cl<sub>2</sub> | 0 |
C-0604 | H | H | H | H | H | 3,4-Cl<sub>2</sub> | 0 |
C-0605 | H | H | H | H | H | 3,5-Cl<sub>2</sub> | 0 |
C-0606 | H | H | H | H | H | 2-Cl,3-Me | 0 |
C-0607 | H | H | H | H | H | 2-Cl,4-Me | 0 |
C-0608 | H | H | H | H | H | 2-Cl,5-Me | 0 |
C-0609 | H | H | H | H | H | 2-Cl,6-Me | 0 |
C-0610 | H | H | H | H | H | 3-Cl,2-Me | 0 |
C-0611 | H | H | H | H | H | 3-Cl,4-Me | 0 |
[表207]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0612 | H | H | H | H | H | 3-Cl,5-Me | 0 |
C-0613 | H | H | H | H | H | 3-Cl,6-Me | 0 |
C-0614 | H | H | H | H | H | 4-Cl,2-Me | 0 |
C-0615 | H | H | H | H | H | 4-Cl,3-Me | 0 |
C-0616 | H | H | H | H | H | 2-Cl,3-CF<sub>3</sub> | 0 |
C-0617 | H | H | H | H | H | 2-Cl,4-CF<sub>3</sub> | 0 |
C-0618 | H | H | H | H | H | 2-Cl,5-CF<sub>3</sub> | 0 |
C-0619 | H | H | H | H | H | 2-Cl,6-CF<sub>3</sub> | 0 |
C-0620 | H | H | H | H | H | 3-Cl,2-CF<sub>3</sub> | 0 |
C-0621 | H | H | H | H | H | 3-Cl,4-CF<sub>3</sub> | 0 |
C-0622 | H | H | H | H | H | 3-Cl,5-CF<sub>3</sub> | 0 |
C-0623 | H | H | H | H | H | 3-Cl,6-CF<sub>3</sub> | 0 |
C-0624 | H | H | H | H | H | 4-Cl,2-CF<sub>3</sub> | 0 |
C-0625 | H | H | H | H | H | 4-Cl,3-CF<sub>3</sub> | 0 |
C-0626 | H | H | H | H | H | 2-Cl,3-OMe | 0 |
C-0627 | H | H | H | H | H | 2-Cl,4-OMe | 0 |
C-0628 | H | H | H | H | H | 2-Cl,5-OMe | 0 |
C-0629 | H | H | H | H | H | 2-Cl,6-OMe | 0 |
C-0630 | H | H | H | H | H | 3-Cl,2-OMe | 0 |
C-0631 | H | H | H | H | H | 3-Cl,4-OMe | 0 |
C-0632 | H | H | H | H | H | 3-Cl,5-OMe | 0 |
C-0633 | H | H | H | H | H | 3-Cl,6-OMe | 0 |
C-0634 | H | H | H | H | H | 4-Cl,2-OMe | 0 |
C-0635 | H | H | H | H | H | 4-Cl,3-OMe | 0 |
C-0636 | H | H | H | H | H | 2,3-Me<sub>2</sub> | 0 |
C-0637 | H | H | H | H | H | 2,4-Me<sub>2</sub> | 0 |
C-0638 | H | H | H | H | H | 2,5-Me<sub>2</sub> | 0 |
C-0639 | H | H | H | H | H | 2,6-Me<sub>2</sub> | 0 |
C-0640 | H | H | H | H | H | 3,4-Me<sub>2</sub> | 0 |
C-0641 | H | H | H | H | H | 3,5-Me<sub>2</sub> | 0 |
C-0642 | H | H | H | H | H | 2-Me,3-CF<sub>3</sub> | 0 |
C-0643 | H | H | H | H | H | 2-Me,4-CF<sub>3</sub> | 0 |
C-0644 | H | H | H | H | H | 2-Me,5-CF<sub>3</sub> | 0 |
C-0645 | H | H | H | H | H | 2-Me,6-CF<sub>3</sub> | 0 |
C-0646 | H | H | H | H | H | 3-Me,2-CF<sub>3</sub> | 0 |
C-0647 | H | H | H | H | H | 3-Me,4-CF<sub>3</sub> | 0 |
C-0648 | H | H | H | H | H | 3-Me,5-CF<sub>3</sub> | 0 |
C-0649 | H | H | H | H | H | 3-Me,6-CF<sub>3</sub> | 0 |
C-0650 | H | H | H | H | H | 4-Me,2-CF<sub>3</sub> | 0 |
C-0651 | H | H | H | H | H | 4-Me,3-CF<sub>3</sub> | 0 |
C-0652 | H | H | H | H | H | 2-Me,3-OMe | 0 |
C-0653 | H | H | H | H | H | 2-Me,4-OMe | 0 |
C-0654 | H | H | H | H | H | 2-Me,5-OMe | 0 |
C-0655 | H | H | H | H | H | 2-Me,6-OMe | 0 |
C-0656 | H | H | H | H | H | 3-Me,2-OMe | 0 |
C-0657 | H | H | H | H | H | 3-Me,4-OMe | 0 |
C-0658 | H | H | H | H | H | 3-Me,5-OMe | 0 |
C-0659 | H | H | H | H | H | 3-Me,6-OMe | 0 |
C-0660 | H | H | H | H | H | 4-Me,2-OMe | 0 |
C-0661 | H | H | H | H | H | 4-Me,3-OMe | 0 |
C-0662 | H | H | H | H | H | 2,3-OMe<sub>2</sub> | 0 |
C-0663 | H | H | H | H | H | 2,4-OMe<sub>2</sub> | 0 |
C-0664 | H | H | H | H | H | 2,5-OMe<sub>2</sub> | 0 |
C-0665 | H | H | H | H | H | 2,6-OMe<sub>2</sub> | 0 |
C-0666 | H | H | H | H | H | 3,4-OMe<sub>2</sub> | 0 |
C-0667 | H | H | H | H | H | 3,5-OMe<sub>2</sub> | 0 |
[表208]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0668 | H | H | H | H | H | 2-OMe,3-CF<sub>3</sub> | 0 |
C-0669 | H | H | H | H | H | 2-OMe,4-CF<sub>3</sub> | 0 |
C-0670 | H | H | H | H | H | 2-OMe,5-CF<sub>3</sub> | 0 |
C-0671 | H | H | H | H | H | 2-OMe,6-CF<sub>3</sub> | 0 |
C-0672 | H | H | H | H | H | 3-OMe,2-CF<sub>3</sub> | 0 |
C-0673 | H | H | H | H | H | 3-OMe,4-CF<sub>3</sub> | 0 |
C-0674 | H | H | H | H | H | 3-OMe,5-CF<sub>3</sub> | 0 |
C-0675 | H | H | H | H | H | 3-OMe,6-CF<sub>3</sub> | 0 |
C-0676 | H | H | H | H | H | 4-OMe,2-CF<sub>3</sub> | 0 |
C-0677 | H | H | H | H | H | 4-OMe,3-CF<sub>3</sub> | 0 |
C-0678 | H | H | H | H | H | 2-CHF<sub>2</sub>,3-F | 0 |
C-0679 | H | H | H | H | H | 2-CHF<sub>2</sub>,4-F | 0 |
C-0680 | H | H | H | H | H | 2-CHF<sub>2</sub>,5-F | 0 |
C-0681 | H | H | H | H | H | 2-CHF<sub>2</sub>,6-F | 0 |
C-0682 | H | H | H | H | H | 2-CHF<sub>2</sub>,3-Me | 0 |
C-0683 | H | H | H | H | H | 2-CHF<sub>2</sub>,4-Me | 0 |
C-0684 | H | H | H | H | H | 2-CHF<sub>2</sub>,5-Me | 0 |
C-0685 | H | H | H | H | H | 2-CHF<sub>2</sub>,6-Me | 0 |
C-0686 | H | H | H | H | H | 2-环丙基,3-F | 0 |
C-0687 | H | H | H | H | H | 2-环丙基,4-F | 0 |
C-0688 | H | H | H | H | H | 2-环丙基,5-F | 0 |
C-0689 | H | H | H | H | H | 2-环丙基,6-F | 0 |
C-0690 | H | H | H | H | H | 2-环丙基,3-Me | 0 |
C-0691 | H | H | H | H | H | 2-环丙基,4-Me | 0 |
C-0692 | H | H | H | H | H | 2-环丙基,5-Me | 0 |
C-0693 | H | H | H | H | H | 2-环丙基,6-Me | 0 |
C-0694 | H | H | H | H | H | 2-乙烯基,3-F | 0 |
C-0695 | H | H | H | H | H | 2-乙烯基,4-F | 0 |
C-0696 | H | H | H | H | H | 2-乙烯基,5-F | 0 |
C-0697 | H | H | H | H | H | 2-乙烯基,6-F | 0 |
C-0698 | H | H | H | H | H | 2-乙烯基,3-Me | 0 |
C-0699 | H | H | H | H | H | 2-乙烯基,4-Me | 0 |
C-0700 | H | H | H | H | H | 2-乙烯基,5-Me | 0 |
C-0701 | H | H | H | H | H | 2-乙烯基,6-Me | 0 |
C-0702 | H | H | H | H | H | 2-OEt,3-F | 0 |
C-0703 | H | H | H | H | H | 2-OEt,4-F | 0 |
C-0704 | H | H | H | H | H | 2-OEt,5-F | 0 |
C-0705 | H | H | H | H | H | 2-OEt,6-F | 0 |
C-0706 | H | H | H | H | H | 2-OEt,3-Cl | 0 |
C-0707 | H | H | H | H | H | 2-OEt,4-Cl | 0 |
C-0708 | H | H | H | H | H | 2-OEt,5-Cl | 0 |
C-0709 | H | H | H | H | H | 2-OEt,6-Cl | 0 |
C-0710 | H | H | H | H | H | 2-OEt,3-Me | 0 |
C-0711 | H | H | H | H | H | 2-OEt,4-Me | 0 |
C-0712 | H | H | H | H | H | 2-OEt,5-Me | 0 |
C-0713 | H | H | H | H | H | 2-OEt,6-Me | 0 |
C-0714 | H | H | H | H | H | 2-OPr,3-F | 0 |
C-0715 | H | H | H | H | H | 2-OPr,4-F | 0 |
C-0716 | H | H | H | H | H | 2-OPr,5-F | 0 |
C-0717 | H | H | H | H | H | 2-OPr,6-F | 0 |
C-0718 | H | H | H | H | H | 2-OPr,3-Me | 0 |
C-0719 | H | H | H | H | H | 2-OPr,4-Me | 0 |
C-0720 | H | H | H | H | H | 2-OPr,5-Me | 0 |
C-0721 | H | H | H | H | H | 2-OPr,6-Me | 0 |
C-0722 | H | H | H | H | H | 2-O(i-Pr),3-F | 0 |
C-0723 | H | H | H | H | H | 2-O(i-Pr),4-F | 0 |
[表209]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0724 | H | H | H | H | H | 2-O(i-Pr),5-F | 0 |
C-0725 | H | H | H | H | H | 2-O(i-Pr),6-F | 0 |
C-0726 | H | H | H | H | H | 2-O(i-Pr),3-Me | 0 |
C-0727 | H | H | H | H | H | 2-O(i-Pr),4-Me | 0 |
C-0728 | H | H | H | H | H | 2-O(i-Pr),5-Me | 0 |
C-0729 | H | H | H | H | H | 2-O(i-Pr),6-Me | 0 |
C-0730 | H | H | H | H | H | 2-OCF<sub>3</sub>,3-F | 0 |
C-0731 | H | H | H | H | H | 2-OCF<sub>3</sub>,4-F | 0 |
C-0732 | H | H | H | H | H | 2-OCF<sub>3</sub>,5-F | 0 |
C-0733 | H | H | H | H | H | 2-OCF<sub>3</sub>,6-F | 0 |
C-0734 | H | H | H | H | H | 2-OCF<sub>3</sub>,3-Me | 0 |
C-0735 | H | H | H | H | H | 2-OCF<sub>3</sub>,4-Me | 0 |
C-0736 | H | H | H | H | H | 2-OCF<sub>3</sub>,5-Me | 0 |
C-0737 | H | H | H | H | H | 2-OCF<sub>3</sub>,6-Me | 0 |
C-0738 | H | H | H | H | H | 2-OCHF<sub>2</sub>,3-F | 0 |
C-0739 | H | H | H | H | H | 2-OCHF<sub>2</sub>,4-F | 0 |
C-0740 | H | H | H | H | H | 2-OCHF<sub>2</sub>,5-F | 0 |
C-0741 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-F | 0 |
C-0742 | H | H | H | H | H | 2-OCHF<sub>2</sub>,3-Me | 0 |
C-0743 | H | H | H | H | H | 2-OCHF<sub>2</sub>,4-Me | 0 |
C-0744 | H | H | H | H | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
C-0745 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
C-0746 | H | H | H | H | H | 2-(环丙基氧基),3-F | 0 |
C-0747 | H | H | H | H | H | 2-(环丙基氧基),4-F | 0 |
C-0748 | H | H | H | H | H | 2-(环丙基氧基),5-F | 0 |
C-0749 | H | H | H | H | H | 2-(环丙基氧基),6-F | 0 |
C-0750 | H | H | H | H | H | 2-(环丙基氧基),3-Me | 0 |
C-0751 | H | H | H | H | H | 2-(环丙基氧基),4-Me | 0 |
C-0752 | H | H | H | H | H | 2-(环丙基氧基),5-Me | 0 |
C-0753 | H | H | H | H | H | 2-(环丙基氧基),6-Me | 0 |
C-0754 | H | H | H | H | H | 2-(环氧乙烷-2-基),3-F | 0 |
C-0755 | H | H | H | H | H | 2-(环氧乙烷-2-基),4-F | 0 |
C-0756 | H | H | H | H | H | 2-(环氧乙烷-2-基),5-F | 0 |
C-0757 | H | H | H | H | H | 2-(环氧乙烷-2-基),6-F | 0 |
C-0758 | H | H | H | H | H | 2-(环氧乙烷-2-基),3-Me | 0 |
C-0759 | H | H | H | H | H | 2-(环氧乙烷-2-基),4-Me | 0 |
C-0760 | H | H | H | H | H | 2-(环氧乙烷-2-基),5-Me | 0 |
C-0761 | H | H | H | H | H | 2-(环氧乙烷-2-基),6-Me | 0 |
C-0762 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),3-F | 0 |
C-0763 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),4-F | 0 |
C-0764 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),5-F | 0 |
C-0765 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),6-F | 0 |
C-0766 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),3-Me | 0 |
C-0767 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),4-Me | 0 |
C-0768 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),5-Me | 0 |
C-0769 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),6-Me | 0 |
C-0770 | H | H | H | H | H | 2-SMe,3-F | 0 |
C-0771 | H | H | H | H | H | 2-SMe,4-F | 0 |
C-0772 | H | H | H | H | H | 2-SMe,5-F | 0 |
C-0773 | H | H | H | H | H | 2-SMe,6-F | 0 |
C-0774 | H | H | H | H | H | 2-SMe,3-Me | 0 |
C-0775 | H | H | H | H | H | 2-SMe,4-Me | 0 |
C-0776 | H | H | H | H | H | 2-SMe,5-Me | 0 |
C-0777 | H | H | H | H | H | 2-SMe,6-Me | 0 |
C-0778 | H | H | H | H | H | 2-SEt,3-F | 0 |
C-0779 | H | H | H | H | H | 2-SEt,4-F | 0 |
[表210]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0780 | H | H | H | H | H | 2-SEt,5-F | 0 |
C-0781 | H | H | H | H | H | 2-SEt,6-F | 0 |
C-0782 | H | H | H | H | H | 2-SEt,3-Me | 0 |
C-0783 | H | H | H | H | H | 2-SEt,4-Me | 0 |
C-0784 | H | H | H | H | H | 2-SEt,5-Me | 0 |
C-0785 | H | H | H | H | H | 2-SEt,6-Me | 0 |
C-0786 | H | H | H | H | H | 2-S(=O)Me,3-F | 0 |
C-0787 | H | H | H | H | H | 2-S(=O)Me,4-F | 0 |
C-0788 | H | H | H | H | H | 2-S(=O)Me,5-F | 0 |
C-0789 | H | H | H | H | H | 2-S(=O)Me,6-F | 0 |
C-0790 | H | H | H | H | H | 3-S(=O)Me,2-F | 0 |
C-0791 | H | H | H | H | H | 3-S(=O)Me,4-F | 0 |
C-0792 | H | H | H | H | H | 3-S(=O)Me,5-F | 0 |
C-0793 | H | H | H | H | H | 3-S(=O)Me,6-F | 0 |
C-0794 | H | H | H | H | H | 2-S(=O)Me,3-Me | 0 |
C-0795 | H | H | H | H | H | 2-S(=O)Me,4-Me | 0 |
C-0796 | H | H | H | H | H | 2-S(=O)Me,5-Me | 0 |
C-0797 | H | H | H | H | H | 2-S(=O)Me,6-Me | 0 |
C-0798 | H | H | H | H | H | 3-S(=O)Me,2-Me | 0 |
C-0799 | H | H | H | H | H | 3-S(=O)Me,4-Me | 0 |
C-0800 | H | H | H | H | H | 3-S(=O)Me,5-Me | 0 |
C-0801 | H | H | H | H | H | 3-S(=O)Me,6-Me | 0 |
C-0802 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,3-F | 0 |
C-0803 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,4-F | 0 |
C-0804 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
C-0805 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
C-0806 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,3-Me | 0 |
C-0807 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,4-Me | 0 |
C-0808 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
C-0809 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
C-0810 | H | H | H | H | H | 2-SCF<sub>3</sub>,3-F | 0 |
C-0811 | H | H | H | H | H | 2-SCF<sub>3</sub>,4-F | 0 |
C-0812 | H | H | H | H | H | 2-SCF<sub>3</sub>,5-F | 0 |
C-0813 | H | H | H | H | H | 2-SCF<sub>3</sub>,6-F | 0 |
C-0814 | H | H | H | H | H | 2-SCF<sub>3</sub>,3-Me | 0 |
C-0815 | H | H | H | H | H | 2-SCF<sub>3</sub>,4-Me | 0 |
C-0816 | H | H | H | H | H | 2-SCF<sub>3</sub>,5-Me | 0 |
C-0817 | H | H | H | H | H | 2-SCF<sub>3</sub>,6-Me | 0 |
C-0818 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,3-F | 0 |
C-0819 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,4-F | 0 |
C-0820 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
C-0821 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
C-0822 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,3-Me | 0 |
C-0823 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,4-Me | 0 |
C-0824 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
C-0825 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
C-0826 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-F | 0 |
C-0827 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-F | 0 |
C-0828 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
C-0829 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
C-0830 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-Me | 0 |
C-0831 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-Me | 0 |
C-0832 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
C-0833 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
C-0834 | H | H | H | H | H | 2-(环丙基硫基),3-F | 0 |
C-0835 | H | H | H | H | H | 2-(环丙基硫基),4-F | 0 |
[表211]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0836 | H | H | H | H | H | 2-(环丙基硫基),5-F | 0 |
C-0837 | H | H | H | H | H | 2-(环丙基硫基),6-F | 0 |
C-0838 | H | H | H | H | H | 2-(环丙基硫基),3-Me | 0 |
C-0839 | H | H | H | H | H | 2-(环丙基硫基),4-Me | 0 |
C-0840 | H | H | H | H | H | 2-(环丙基硫基),5-Me | 0 |
C-0841 | H | H | H | H | H | 2-(环丙基硫基),6-Me | 0 |
C-0842 | H | H | H | H | H | 2-C(=O)Me,3-F | 0 |
C-0843 | H | H | H | H | H | 2-C(=O)Me,4-F | 0 |
C-0844 | H | H | H | H | H | 2-C(=O)Me,5-F | 0 |
C-0845 | H | H | H | H | H | 2-C(=O)Me,6-F | 0 |
C-0846 | H | H | H | H | H | 2-C(=O)Me,3-Me | 0 |
C-0847 | H | H | H | H | H | 2-C(=O)Me,4-Me | 0 |
C-0848 | H | H | H | H | H | 2-C(=O)Me,5-Me | 0 |
C-0849 | H | H | H | H | H | 2-C(=O)Me,6-Me | 0 |
C-0850 | H | H | H | H | H | 3-C(=O)Me,2-F | 0 |
C-0851 | H | H | H | H | H | 3-C(=O)Me,4-F | 0 |
C-0852 | H | H | H | H | H | 3-C(=O)Me,5-F | 0 |
C-0853 | H | H | H | H | H | 3-C(=O)Me,6-F | 0 |
C-0854 | H | H | H | H | H | 3-C(=O)Me,2-Me | 0 |
C-0855 | H | H | H | H | H | 3-C(=O)Me,4-Me | 0 |
C-0856 | H | H | H | H | H | 3-C(=O)Me,5-Me | 0 |
C-0857 | H | H | H | H | H | 3-C(=O)Me,6-Me | 0 |
C-0858 | H | H | H | H | H | 2-C(=O)OMe,3-F | 0 |
C-0859 | H | H | H | H | H | 2-C(=O)OMe,4-F | 0 |
C-0860 | H | H | H | H | H | 2-C(=O)OMe,5-F | 0 |
C-0861 | H | H | H | H | H | 2-C(=O)OMe,6-F | 0 |
C-0862 | H | H | H | H | H | 2-C(=O)OMe,3-Me | 0 |
C-0863 | H | H | H | H | H | 2-C(=O)OMe,4-Me | 0 |
C-0864 | H | H | H | H | H | 2-C(=O)OMe,5-Me | 0 |
C-0865 | H | H | H | H | H | 2-C(=O)OMe,6-Me | 0 |
C-0866 | H | H | H | H | H | 2-C(=O)OEt,3-F | 0 |
C-0867 | H | H | H | H | H | 2-C(=O)OEt,4-F | 0 |
C-0868 | H | H | H | H | H | 2-C(=O)OEt,5-F | 0 |
C-0869 | H | H | H | H | H | 2-C(=O)OEt,6-F | 0 |
C-0870 | H | H | H | H | H | 2-C(=O)OEt,3-Me | 0 |
C-0871 | H | H | H | H | H | 2-C(=O)OEt,4-Me | 0 |
C-0872 | H | H | H | H | H | 2-C(=O)OEt,5-Me | 0 |
C-0873 | H | H | H | H | H | 2-C(=O)OEt,6-Me | 0 |
C-0874 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,3-F | 0 |
C-0875 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,4-F | 0 |
C-0876 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,5-F | 0 |
C-0877 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,6-F | 0 |
C-0878 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,3-Me | 0 |
C-0879 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,4-Me | 0 |
C-0880 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,5-Me | 0 |
C-0881 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,6-Me | 0 |
C-0882 | H | H | H | H | H | 2-C(=O)NHMe,3-F | 0 |
C-0883 | H | H | H | H | H | 2-C(=O)NHMe,4-F | 0 |
C-0884 | H | H | H | H | H | 2-C(=O)NHMe,5-F | 0 |
C-0885 | H | H | H | H | H | 2-C(=O)NHMe,6-F | 0 |
C-0886 | H | H | H | H | H | 2-C(=O)NHMe,3-Me | 0 |
C-0887 | H | H | H | H | H | 2-C(=O)NHMe,4-Me | 0 |
C-0888 | H | H | H | H | H | 2-C(=O)NHMe,5-Me | 0 |
C-0889 | H | H | H | H | H | 2-C(=O)NHMe,6-Me | 0 |
C-0890 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,3-F | 0 |
C-0891 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,4-F | 0 |
[表212]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0892 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,5-F | 0 |
C-0893 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,6-F | 0 |
C-0894 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,3-Me | 0 |
C-0895 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,4-Me | 0 |
C-0896 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,5-Me | 0 |
C-0897 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,6-Me | 0 |
C-0898 | H | H | H | H | H | 2-CH<sub>2</sub>OH,3-F | 0 |
C-0899 | H | H | H | H | H | 2-CH<sub>2</sub>OH,4-F | 0 |
C-0900 | H | H | H | H | H | 2-CH<sub>2</sub>OH,5-F | 0 |
C-0901 | H | H | H | H | H | 2-CH<sub>2</sub>OH,6-F | 0 |
C-0902 | H | H | H | H | H | 2-CH<sub>2</sub>OH,3-Me | 0 |
C-0903 | H | H | H | H | H | 2-CH<sub>2</sub>OH,4-Me | 0 |
C-0904 | H | H | H | H | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
C-0905 | H | H | H | H | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
C-0906 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-F | 0 |
C-0907 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
C-0908 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
C-0909 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
C-0910 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-Me | 0 |
C-0911 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
C-0912 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
C-0913 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
C-0914 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-F | 0 |
C-0915 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-F | 0 |
C-0916 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
C-0917 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
C-0918 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-Me | 0 |
C-0919 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-Me | 0 |
C-0920 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
C-0921 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
C-0922 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,3-F | 0 |
C-0923 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,4-F | 0 |
C-0924 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
C-0925 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
C-0926 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,3-Me | 0 |
C-0927 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,4-Me | 0 |
C-0928 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
C-0929 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
C-0930 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-F | 0 |
C-0931 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-F | 0 |
C-0932 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
C-0933 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
C-0934 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-Me | 0 |
C-0935 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-Me | 0 |
C-0936 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
C-0937 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
C-0938 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-F | 0 |
C-0939 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-F | 0 |
C-0940 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
C-0941 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
C-0942 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-Me | 0 |
C-0943 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-Me | 0 |
C-0944 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
C-0945 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
C-0946 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-F | 0 |
C-0947 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-F | 0 |
[表213]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-0948 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-F | 0 |
C-0949 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-F | 0 |
C-0950 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-Me | 0 |
C-0951 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-Me | 0 |
C-0952 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-Me | 0 |
C-0953 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-Me | 0 |
C-0954 | H | H | H | H | H | 2-(苯甲基氧基),3-F | 0 |
C-0955 | H | H | H | H | H | 2-(苯甲基氧基),4-F | 0 |
C-0956 | H | H | H | H | H | 2-(苯甲基氧基),5-F | 0 |
C-0957 | H | H | H | H | H | 2-(苯甲基氧基),6-F | 0 |
C-0958 | H | H | H | H | H | 2-(苯甲基氧基),3-Me | 0 |
C-0959 | H | H | H | H | H | 2-(苯甲基氧基),4-Me | 0 |
C-0960 | H | H | H | H | H | 2-(苯甲基氧基),5-Me | 0 |
C-0961 | H | H | H | H | H | 2-(苯甲基氧基),6-Me | 0 |
C-0962 | H | H | H | H | H | 2-NH<sub>2</sub>,3-F | 0 |
C-0963 | H | H | H | H | H | 2-NH<sub>2</sub>,4-F | 0 |
C-0964 | H | H | H | H | H | 2-NH<sub>2</sub>,5-F | 0 |
C-0965 | H | H | H | H | H | 2-NH<sub>2</sub>,6-F | 0 |
C-0966 | H | H | H | H | H | 2-NH<sub>2</sub>,3-Me | 0 |
C-0967 | H | H | H | H | H | 2-NH<sub>2</sub>,4-Me | 0 |
C-0968 | H | H | H | H | H | 2-NH<sub>2</sub>,5-Me | 0 |
C-0969 | H | H | H | H | H | 2-NH<sub>2</sub>,6-Me | 0 |
C-0970 | H | H | H | H | H | 2-NHMe,3-F | 0 |
C-0971 | H | H | H | H | H | 2-NHMe,4-F | 0 |
C-0972 | H | H | H | H | H | 2-NHMe,5-F | 0 |
C-0973 | H | H | H | H | H | 2-NHMe,6-F | 0 |
C-0974 | H | H | H | H | H | 2-NHMe,3-Me | 0 |
C-0975 | H | H | H | H | H | 2-NHMe,4-Me | 0 |
C-0976 | H | H | H | H | H | 2-NHMe,5-Me | 0 |
C-0977 | H | H | H | H | H | 2-NHMe,6-Me | 0 |
C-0978 | H | H | H | H | H | 2-NHEt,3-F | 0 |
C-0979 | H | H | H | H | H | 2-NHEt,4-F | 0 |
C-0980 | H | H | H | H | H | 2-NHEt,5-F | 0 |
C-0981 | H | H | H | H | H | 2-NHEt,6-F | 0 |
C-0982 | H | H | H | H | H | 2-NHEt,3-Me | 0 |
C-0983 | H | H | H | H | H | 2-NHEt,4-Me | 0 |
C-0984 | H | H | H | H | H | 2-NHEt,5-Me | 0 |
C-0985 | H | H | H | H | H | 2-NHEt,6-Me | 0 |
C-0986 | H | H | H | H | H | 2-NMe<sub>2</sub>,3-F | 0 |
C-0987 | H | H | H | H | H | 2-NMe<sub>2</sub>,4-F | 0 |
C-0988 | H | H | H | H | H | 2-NMe<sub>2</sub>,5-F | 0 |
C-0989 | H | H | H | H | H | 2-NMe<sub>2</sub>,6-F | 0 |
C-0990 | H | H | H | H | H | 2-NMe<sub>2</sub>,3-Me | 0 |
C-0991 | H | H | H | H | H | 2-NMe<sub>2</sub>,4-Me | 0 |
C-0992 | H | H | H | H | H | 2-NMe<sub>2</sub>,5-Me | 0 |
C-0993 | H | H | H | H | H | 2-NMe<sub>2</sub>,6-Me | 0 |
C-0994 | H | H | H | H | H | 2-NEt<sub>2</sub>,3-F | 0 |
C-0995 | H | H | H | H | H | 2-NEt<sub>2</sub>,4-F | 0 |
C-0996 | H | H | H | H | H | 2-NEt<sub>2</sub>,5-F | 0 |
C-0997 | H | H | H | H | H | 2-NEt<sub>2</sub>,6-F | 0 |
C-0998 | H | H | H | H | H | 2-NEt<sub>2</sub>,3-Me | 0 |
C-0999 | H | H | H | H | H | 2-NEt<sub>2</sub>,4-Me | 0 |
C-1000 | H | H | H | H | H | 2-NEt<sub>2</sub>,5-Me | 0 |
C-1001 | H | H | H | H | H | 2-NEt<sub>2</sub>,6-Me | 0 |
C-1002 | H | H | H | H | H | 2-CHO,3-F | 0 |
C-1003 | H | H | H | H | H | 2-CHO,4-F | 0 |
[表214]
[表215]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-1060 | H | H | H | H | H | 2-CH=NOMe,5-F | 0 |
C-1061 | H | H | H | H | H | 2-CH=NOMe,6-F | 0 |
C-1062 | H | H | H | H | H | 2-CH=NOMe,3-Me | 0 |
C-1063 | H | H | H | H | H | 2-CH=NOMe,4-Me | 0 |
C-1064 | H | H | H | H | H | 2-CH=NOMe,5-Me | 0 |
C-1065 | H | H | H | H | H | 2-CH=NOMe,6-Me | 0 |
C-1066 | H | H | H | H | H | 2-CN,3-F | 0 |
C-1067 | H | H | H | H | H | 2-CN,4-F | 0 |
C-1068 | H | H | H | H | H | 2-CN,5-F | 0 |
C-1069 | H | H | H | H | H | 2-CN,6-F | 0 |
C-1070 | H | H | H | H | H | 2-CN,3-Cl | 0 |
C-1071 | H | H | H | H | H | 2-CN,4-Cl | 0 |
C-1072 | H | H | H | H | H | 2-CN,5-Cl | 0 |
C-1073 | H | H | H | H | H | 2-CN,6-Cl | 0 |
C-1074 | H | H | H | H | H | 2-CN,3-Me | 0 |
C-1075 | H | H | H | H | H | 2-CN,4-Me | 0 |
C-1076 | H | H | H | H | H | 2-CN,5-Me | 0 |
C-1077 | H | H | H | H | H | 2-CN,6-Me | 0 |
C-1078 | H | H | H | H | H | 2-CN,3-OMe | 0 |
C-1079 | H | H | H | H | H | 2-CN,4-OMe | 0 |
C-1080 | H | H | H | H | H | 2-CN,5-OMe | 0 |
C-1081 | H | H | H | H | H | 2-CN,6-OMe | 0 |
C-1082 | H | H | H | H | H | 3-CN,2-F | 0 |
C-1083 | H | H | H | H | H | 3-CN,4-F | 0 |
C-1084 | H | H | H | H | H | 3-CN,5-F | 0 |
C-1085 | H | H | H | H | H | 3-CN,6-F | 0 |
C-1086 | H | H | H | H | H | 3-CN,2-Cl | 0 |
C-1087 | H | H | H | H | H | 3-CN,4-Cl | 0 |
C-1088 | H | H | H | H | H | 3-CN,5-Cl | 0 |
C-1089 | H | H | H | H | H | 3-CN,6-Cl | 0 |
C-1090 | H | H | H | H | H | 3-CN,2-Me | 0 |
C-1091 | H | H | H | H | H | 3-CN,4-Me | 0 |
C-1092 | H | H | H | H | H | 3-CN,5-Me | 0 |
C-1093 | H | H | H | H | H | 3-CN,6-Me | 0 |
C-1094 | H | H | H | H | H | 3-CN,2-OMe | 0 |
C-1095 | H | H | H | H | H | 3-CN,4-OMe | 0 |
C-1096 | H | H | H | H | H | 3-CN,5-OMe | 0 |
C-1097 | H | H | H | H | H | 3-CN,6-OMe | 0 |
C-1098 | H | H | H | H | H | 4-CN,2-F | 0 |
C-1099 | H | H | H | H | H | 4-CN,3-F | 0 |
C-1100 | H | H | H | H | H | 4-CN,2-Cl | 0 |
C-1101 | H | H | H | H | H | 4-CN,3-Cl | 0 |
C-1102 | H | H | H | H | H | 4-CN,2-Me | 0 |
C-1103 | H | H | H | H | H | 4-CN,3-Me | 0 |
C-1104 | H | H | H | H | H | 4-CN,2-OMe | 0 |
C-1105 | H | H | H | H | H | 4-CN,3-OMe | 0 |
C-1106 | H | H | H | H | H | 2-NO<sub>2</sub>,3-F | 0 |
C-1107 | H | H | H | H | H | 2-NO<sub>2</sub>,4-F | 0 |
C-1108 | H | H | H | H | H | 2-NO<sub>2</sub>,5-F | 0 |
C-1109 | H | H | H | H | H | 2-NO<sub>2</sub>,6-F | 0 |
C-1110 | H | H | H | H | H | 2-NO<sub>2</sub>,3-Me | 0 |
C-1111 | H | H | H | H | H | 2-NO<sub>2</sub>,4-Me | 0 |
C-1112 | H | H | H | H | H | 2-NO<sub>2</sub>,5-Me | 0 |
C-1113 | H | H | H | H | H | 2-NO<sub>2</sub>,6-Me | 0 |
C-1114 | H | H | H | H | H | 2-Me,3,4-F<sub>2</sub> | 0 |
C-1115 | H | H | H | H | H | 2-Me,3,5-F<sub>2</sub> | 0 |
[表216]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-1116 | H | H | H | H | H | 2-Me,3,6-F<sub>2</sub> | 0 |
C-1117 | H | H | H | H | H | 2-Me,4,5-F<sub>2</sub> | 0 |
C-1118 | H | H | H | H | H | 2-OMe,3,4-F<sub>2</sub> | 0 |
C-1119 | H | H | H | H | H | 2-OMe,3,5-F<sub>2</sub> | 0 |
C-1120 | H | H | H | H | H | 2-OMe,3,6-F<sub>2</sub> | 0 |
C-1121 | H | H | H | H | H | 2-OMe,4,5-F<sub>2</sub> | 0 |
C-1122 | H | H | H | H | H | 2-(CH<sub>2</sub>)<sub>3</sub>-3 | 0 |
C-1123 | H | H | H | H | H | 2-(CH<sub>2</sub>)<sub>4</sub>-3 | 0 |
C-1124 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>)-3 | 0 |
C-1125 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-3 | 0 |
C-1126 | H | H | H | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>O)-3 | 0 |
C-1127 | H | H | H | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-3 | 0 |
C-1128 | H | H | H | H | H | 3-(CH<sub>2</sub>)<sub>3</sub>-4 | 0 |
C-1129 | H | H | H | H | H | 3-(CH<sub>2</sub>)<sub>4</sub>-4 | 0 |
C-1130 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>)-4 | 0 |
C-1131 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-4 | 0 |
C-1132 | H | H | H | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>O)-4 | 0 |
C-1133 | H | H | H | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-4 | 0 |
C-1134 | H | H | H | H | H | 2-(OCH<sub>2</sub>O)-3 | 0 |
C-1135 | H | H | H | H | H | 3-(OCH<sub>2</sub>O)-4 | 0 |
C-1136 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>O)-3 | 0 |
C-1137 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>O)-4 | 0 |
C-1138 | H | H | H | H | H | 2-(OCF<sub>2</sub>O)-3 | 0 |
C-1139 | H | H | H | H | H | 3-(OCF<sub>2</sub>O)-4 | 0 |
C-1140 | H | H | H | H | H | 2-Me,6-Et | 0 |
C-1141 | H | H | H | H | H | 2-CH<sub>2</sub>OTBS | 0 |
C-1142 | H | H | H | H | H | 2-环丙基,3-OMe | 0 |
C-1143 | H | H | H | H | H | 2-环丙基,4-OMe | 0 |
C-1144 | H | H | H | H | H | 2-环丙基,5-OMe | 0 |
C-1145 | H | H | H | H | H | 2-环丙基,6-OMe | 0 |
C-1146 | H | H | H | H | H | 2-Me,3-OMe,6-Me | 0 |
C-1147 | H | H | H | H | H | 2-Me,4-OMe,6-Me | 0 |
C-1148 | H | H | H | H | H | 2-OMe,3-Me,6-Me | 0 |
C-1149 | H | H | H | H | H | 2-OMe,5-Me,6-Me | 0 |
C-1150 | H | H | H | H | H | 2-OMe,3-F,6-Me | 0 |
C-1151 | H | H | H | H | H | 2-OMe,5-F,6-Me | 0 |
C-1152 | H | H | H | H | H | 2-OMe,5-Me,6-F | 0 |
C-1153 | H | H | H | H | H | 2-Cl,3-Me,6-F | 0 |
C-1154 | H | H | H | H | H | 2-Cl,5-Me,6-F | 0 |
C-1155 | H | H | H | H | H | 2-Cl,3-OMe,6-F | 0 |
C-1156 | H | H | H | H | H | 2-Cl,5-OMe,6-F | 0 |
C-1157 | H | H | H | H | H | 2-Me,5-Et | 0 |
C-1158 | H | H | H | H | H | 2,6-Et<sub>2</sub> | 0 |
C-1159 | H | H | H | H | H | 2-Et,6-F | 0 |
C-1160 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
C-1161 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
C-1162 | H | H | H | H | H | 2-OMe,5-CH=NOMe | 0 |
C-1163 | H | H | H | H | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
C-1164 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-CF<sub>3</sub> | 0 |
C-1165 | H | H | F | H | H | 2-Me | 0 |
C-1166 | H | H | F | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-OMe | 0 |
C-1167 | H | H | F | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-OMe | 0 |
C-1168 | H | H | F | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-CN | 0 |
C-1169 | H | H | F | H | H | 2-OEt,6-CN | 0 |
C-1170 | H | H | F | H | H | 2-OEt,6-OMe | 0 |
C-1171 | H | H | F | H | H | 2,6-OEt<sub>2</sub> | 0 |
[表217]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-1172 | H | H | H | H | H | 2-CN,6-环丙基 | 0 |
C-1173 | H | H | H | H | H | 2-MeO,3-Me,6-MeO | 0 |
C-1174 | H | H | H | H | H | 2-MeO,4-Me,6-MeO | 0 |
C-1175 | H | H | H | H | H | 2-MeO,3-F,6-MeO | 0 |
C-1176 | H | H | H | H | H | 2-MeO,4-F,6-MeO | 0 |
C-1177 | H | H | H | H | H | 2-Et,6-OEt | 0 |
C-1178 | H | H | H | H | H | 2-环丙基,6-Oet | 0 |
C-1179 | H | H | H | H | H | 2,6-SMe<sub>2</sub> | 0 |
C-1180 | H | H | H | H | H | 2-NO<sub>2</sub>,6-OMe | 0 |
C-1181 | H | H | H | H | H | 2-NO<sub>2</sub>,6-CN | 0 |
C-1182 | H | H | H | H | H | 2-Cl,6-NO<sub>2</sub> | 0 |
C-1183 | H | H | H | H | H | 2-Cl,6-SMe | 0 |
C-1184 | H | H | H | H | H | 2-Cl,6-Et | 0 |
C-1185 | H | H | H | H | H | 2-CN,6-SMe | 0 |
C-1186 | H | H | H | H | H | 2,6-CN<sub>2</sub> | 0 |
C-1187 | H | H | H | H | H | 2-OMe,6-OCF<sub>3</sub> | 0 |
C-1188 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-OMe | 0 |
C-1189 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-OMe | 0 |
C-1190 | H | H | H | H | H | 2-Cl,6-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
C-1191 | H | H | H | H | H | 2-CN,6-Et | 0 |
C-1192 | H | H | H | H | H | 2-Et,6-OMe | 0 |
C-1193 | H | H | H | H | H | 2-(吡啶-2-基) | 0 |
C-1194 | H | H | H | H | H | 3-(吡啶-2-基) | 0 |
C-1195 | H | H | H | H | H | 4-(吡啶-2-基) | 0 |
C-1196 | H | H | H | H | H | 2-(嘧啶-2-基) | 0 |
C-1197 | H | H | H | H | H | 3-(嘧啶-2-基) | 0 |
C-1198 | H | H | H | H | H | 4-(嘧啶-2-基) | 0 |
C-1199 | H | H | H | H | H | 2-(吡嗪-2-基) | 0 |
C-1200 | H | H | H | H | H | 3-(吡嗪-2-基) | 0 |
C-1201 | H | H | H | H | H | 4-(吡嗪-2-基) | 0 |
C-1202 | H | H | H | H | H | 2-(1,3,5-三嗪-2-基) | 0 |
C-1203 | H | H | H | H | H | 3-(1,3,5-三嗪-2-基) | 0 |
C-1204 | H | H | H | H | H | 4-(1,3,5-三嗪-2-基) | 0 |
C-1205 | H | H | H | H | H | 2-(1,2,4-三嗪-3-基) | 0 |
C-1206 | H | H | H | H | H | 3-(1,2,4-三嗪-3-基) | 0 |
C-1207 | H | H | H | H | H | 4-(1,2,4-三嗪-3-基) | 0 |
C-1208 | H | H | H | H | H | 2-(1,2,4-三嗪-6-基) | 0 |
C-1209 | H | H | H | H | H | 3-(1,2,4-三嗪-6-基) | 0 |
C-1210 | H | H | H | H | H | 4-(1,2,4-三嗪-6-基) | 0 |
C-1211 | H | H | H | H | H | 2-(1H-吡唑-1-基) | 0 |
C-1212 | H | H | H | H | H | 3-(1H-吡唑-1-基) | 0 |
C-1213 | H | H | H | H | H | 4-(1H-吡唑-1-基) | 0 |
[表218]
[表219]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5053 | H | H | H | H | H | 2-CF<sub>2</sub>Cl | 1 |
C-5054 | H | H | H | H | H | 3-CF<sub>2</sub>Cl | 1 |
C-5055 | H | H | H | H | H | 4-CF<sub>2</sub>Cl | 1 |
C-5056 | H | H | H | H | H | 2-CF(CF<sub>3</sub>)<sub>2</sub> | 1 |
C-5057 | H | H | H | H | H | 3-CF(CF<sub>3</sub>)<sub>2</sub> | 1 |
C-5058 | H | H | H | H | H | 4-CF(CF<sub>3</sub>)<sub>2</sub> | 1 |
C-5059 | H | H | H | H | H | 2-环丙基 | 1 |
C-5060 | H | H | H | H | H | 3-环丙基 | 1 |
C-5061 | H | H | H | H | H | 4-环丙基 | 1 |
C-5062 | H | H | H | H | H | 2-环丁基 | 1 |
C-5063 | H | H | H | H | H | 3-环丁基 | 1 |
C-5064 | H | H | H | H | H | 4-环丁基 | 1 |
C-5065 | H | H | H | H | H | 2-环戊基 | 1 |
C-5066 | H | H | H | H | H | 3-环戊基 | 1 |
C-5067 | H | H | H | H | H | 4-环戊基 | 1 |
C-5068 | H | H | H | H | H | 2-(环丙基甲基) | 1 |
C-5069 | H | H | H | H | H | 3-(环丙基甲基) | 1 |
C-5070 | H | H | H | H | H | 4-(环丙基甲基) | 1 |
C-5071 | H | H | H | H | H | 2-(环丁基甲基) | 1 |
C-5072 | H | H | H | H | H | 3-(环丁基甲基) | 1 |
C-5073 | H | H | H | H | H | 4-(环丁基甲基) | 1 |
C-5074 | H | H | H | H | H | 2-(环戊基甲基) | 1 |
C-5075 | H | H | H | H | H | 3-(环戊基甲基) | 1 |
C-5076 | H | H | H | H | H | 4-(环戊基甲基) | 1 |
C-5077 | H | H | H | H | H | 2-(环丙基乙基) | 1 |
C-5078 | H | H | H | H | H | 3-(环丙基乙基) | 1 |
C-5079 | H | H | H | H | H | 4-(环丙基乙基) | 1 |
C-5080 | H | H | H | H | H | 2-(2,2-二氟环丙基) | 1 |
C-5081 | H | H | H | H | H | 3-(2,2-二氟环丙基) | 1 |
C-5082 | H | H | H | H | H | 4-(2,2-二氟环丙基) | 1 |
C-5083 | H | H | H | H | H | 2-(2,2-二氯环丙基) | 1 |
C-5084 | H | H | H | H | H | 3-(2,2-二氯环丙基) | 1 |
C-5085 | H | H | H | H | H | 4-(2,2-二氯环丙基) | 1 |
C-5086 | H | H | H | H | H | 2-乙烯基 | 1 |
C-5087 | H | H | H | H | H | 3-乙烯基 | 1 |
C-5088 | H | H | H | H | H | 4-乙烯基 | 1 |
C-5089 | H | H | H | H | H | 2-烯丙基 | 1 |
C-5090 | H | H | H | H | H | 3-烯丙基 | 1 |
C-5091 | H | H | H | H | H | 4-烯丙基 | 1 |
C-5092 | H | H | H | H | H | 2-(丙-1-烯-1-基) | 1 |
C-5093 | H | H | H | H | H | 3-(丙-1-烯-1-基) | 1 |
C-5094 | H | H | H | H | H | 4-(丙-1-烯-1-基) | 1 |
C-5095 | H | H | H | H | H | 2-(三氟乙烯基) | 1 |
C-5096 | H | H | H | H | H | 3-(三氟乙烯基) | 1 |
C-5097 | H | H | H | H | H | 4-(三氟乙烯基) | 1 |
C-5098 | H | H | H | H | H | 2-(2,2-二氯乙烯基) | 1 |
C-5099 | H | H | H | H | H | 3-(2,2-二氯乙烯基) | 1 |
C-5100 | H | H | H | H | H | 4-(2,2-二氯乙烯基) | 1 |
C-5101 | H | H | H | H | H | 2-乙炔基 | 1 |
C-5102 | H | H | H | H | H | 3-乙炔基 | 1 |
C-5103 | H | H | H | H | H | 4-乙炔基 | 1 |
C-5104 | H | H | H | H | H | 2-(1-丙炔-1-基) | 1 |
C-5105 | H | H | H | H | H | 3-(1-丙炔-1-基) | 1 |
C-5106 | H | H | H | H | H | 4-(1-丙炔-1-基) | 1 |
C-5107 | H | H | H | H | H | 2-(2-丙炔-1-基) | 1 |
C-5108 | H | H | H | H | H | 3-(2-丙炔-1-基) | 1 |
C-5109 | H | H | H | H | H | 4-(2-丙炔-1-基) | 1 |
[表220]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5110 | H | H | H | H | H | 2-(2-环丙基乙炔基) | 1 |
C-5111 | H | H | H | H | H | 3-(2-环丙基乙炔基) | 1 |
C-5112 | H | H | H | H | H | 4-(2-环丙基乙炔基) | 1 |
C-5113 | H | H | H | H | H | 2-(2-氯乙炔基) | 1 |
C-5114 | H | H | H | H | H | 3-(2-氯乙炔基) | 1 |
C-5115 | H | H | H | H | H | 4-(2-氯乙炔基) | 1 |
C-5116 | H | H | H | H | H | 2-(2-溴乙炔基) | 1 |
C-5117 | H | H | H | H | H | 3-(2-溴乙炔基) | 1 |
C-5118 | H | H | H | H | H | 4-(2-溴乙炔基) | 1 |
C-5119 | H | H | H | H | H | 2-OMe | 1 |
C-5120 | H | H | H | H | H | 3-OMe | 1 |
C-5121 | H | H | H | H | H | 4-OMe | 1 |
C-5122 | H | H | H | H | H | 2-OEt | 1 |
C-5123 | H | H | H | H | H | 3-OEt | 1 |
C-5124 | H | H | H | H | H | 4-OEt | 1 |
C-5125 | H | H | H | H | H | 2-OPr | 1 |
C-5126 | H | H | H | H | H | 3-OPr | 1 |
C-5127 | H | H | H | H | H | 4-OPr | 1 |
C-5128 | H | H | H | H | H | 2-O(i-Pr) | 1 |
C-5129 | H | H | H | H | H | 3-O(i-Pr) | 1 |
C-5130 | H | H | H | H | H | 4-O(i-Pr) | 1 |
C-5131 | H | H | H | H | H | 2-OBu | 1 |
C-5132 | H | H | H | H | H | 3-OBu | 1 |
C-5133 | H | H | H | H | H | 4-OBu | 1 |
C-5134 | H | H | H | H | H | 2-O(s-Bu) | 1 |
C-5135 | H | H | H | H | H | 3-O(s-Bu) | 1 |
C-5136 | H | H | H | H | H | 4-O(s-Bu) | 1 |
C-5137 | H | H | H | H | H | 2-O(i-Bu) | 1 |
C-5138 | H | H | H | H | H | 3-O(i-Bu) | 1 |
C-5139 | H | H | H | H | H | 4-O(i-Bu) | 1 |
C-5140 | H | H | H | H | H | 2-O(t-Bu) | 1 |
C-5141 | H | H | H | H | H | 3-O(t-Bu) | 1 |
C-5142 | H | H | H | H | H | 4-O(t-Bu) | 1 |
C-5143 | H | H | H | H | H | 2-OCF<sub>3</sub> | 1 |
C-5144 | H | H | H | H | H | 3-OCF<sub>3</sub> | 1 |
C-5145 | H | H | H | H | H | 4-OCF<sub>3</sub> | 1 |
C-5146 | H | H | H | H | H | 2-OCHF<sub>2</sub> | 1 |
C-5147 | H | H | H | H | H | 3-OCHF<sub>2</sub> | 1 |
C-5148 | H | H | H | H | H | 4-OCHF<sub>2</sub> | 1 |
C-5149 | H | H | H | H | H | 2-OCH<sub>2</sub>CF<sub>3</sub> | 1 |
C-5150 | H | H | H | H | H | 3-OCH<sub>2</sub>CF<sub>3</sub> | 1 |
C-5151 | H | H | H | H | H | 4-OCH<sub>2</sub>CF<sub>3</sub> | 1 |
C-5152 | H | H | H | H | H | 2-(环丙基氧基) | 1 |
C-5153 | H | H | H | H | H | 3-(环丙基氧基) | 1 |
C-5154 | H | H | H | H | H | 4-(环丙基氧基) | 1 |
C-5155 | H | H | H | H | H | 2-(环丁基氧基) | 1 |
C-5156 | H | H | H | H | H | 3-(环丁基氧基) | 1 |
C-5157 | H | H | H | H | H | 4-(环丁基氧基) | 1 |
C-5158 | H | H | H | H | H | 2-(环戊基氧基) | 1 |
C-5159 | H | H | H | H | H | 3-(环戊基氧基) | 1 |
C-5160 | H | H | H | H | H | 4-(环戊基氧基) | 1 |
C-5161 | H | H | H | H | H | 2-((2,2-二氯环丙基)氧基) | 1 |
C-5162 | H | H | H | H | H | 3-((2,2-二氯环丙基)氧基) | 1 |
C-5163 | H | H | H | H | H | 4-((2,2-二氯环丙基)氧基) | 1 |
C-5164 | H | H | H | H | H | 2-(环丙基甲氧基) | 1 |
C-5165 | H | H | H | H | H | 3-(环丙基甲氧基) | 1 |
C-5166 | H | H | H | H | H | 4-(环丙基甲氧基) | 1 |
[表211]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5167 | H | H | H | H | H | 2-((2,2-二氟环丙基)甲氧基) | 1 |
C-5168 | H | H | H | H | H | 3-((2,2-二氟环丙基)甲氧基) | 1 |
C-5169 | H | H | H | H | H | 4-((2,2-二氟环丙基)甲氧基) | 1 |
C-5170 | H | H | H | H | H | 2-(环氧乙烷-2-基) | 1 |
C-5171 | H | H | H | H | H | 3-(环氧乙烷-2-基) | 1 |
C-5172 | H | H | H | H | H | 4-(环氧乙烷-2-基) | 1 |
C-5173 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基) | 1 |
C-5174 | H | H | H | H | H | 3-(环氧乙烷-2-基甲基) | 1 |
C-5175 | H | H | H | H | H | 4-(环氧乙烷-2-基甲基) | 1 |
C-5176 | H | H | H | H | H | 2-SMe | 1 |
C-5177 | H | H | H | H | H | 3-SMe | 1 |
C-5178 | H | H | H | H | H | 4-SMe | 1 |
C-5179 | H | H | H | H | H | 2-SEt | 1 |
C-5180 | H | H | H | H | H | 3-SEt | 1 |
C-5181 | H | H | H | H | H | 4-SEt | 1 |
C-5182 | H | H | H | H | H | 2-S(=O)Me | 1 |
C-5183 | H | H | H | H | H | 3-S(=O)Me | 1 |
C-5184 | H | H | H | H | H | 4-S(=O)Me | 1 |
C-5185 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me | 1 |
C-5186 | H | H | H | H | H | 3-S(=O)<sub>2</sub>Me | 1 |
C-5187 | H | H | H | H | H | 4-S(=O)<sub>2</sub>Me | 1 |
C-5188 | H | H | H | H | H | 2-SCF<sub>3</sub> | 1 |
C-5189 | H | H | H | H | H | 3-SCF<sub>3</sub> | 1 |
C-5190 | H | H | H | H | H | 4-SCF<sub>3</sub> | 1 |
C-5191 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub> | 1 |
C-5192 | H | H | H | H | H | 3-S(=O)CF<sub>3</sub> | 1 |
C-5193 | H | H | H | H | H | 4-S(=O)CF<sub>3</sub> | 1 |
C-5194 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
C-5195 | H | H | H | H | H | 3-S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
C-5196 | H | H | H | H | H | 4-S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
C-5197 | H | H | H | H | H | 2-SCF(CF<sub>3</sub>)<sub>2</sub> | 1 |
C-5198 | H | H | H | H | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 1 |
C-5199 | H | H | H | H | H | 4-SCF(CF<sub>3</sub>)<sub>2</sub> | 1 |
C-5200 | H | H | H | H | H | 2-(环丙基硫基) | 1 |
C-5201 | H | H | H | H | H | 3-(环丙基硫基) | 1 |
C-5202 | H | H | H | H | H | 4-(环丙基硫基) | 1 |
C-5203 | H | H | H | H | H | 2-(环丙基亚磺酰基) | 1 |
C-5204 | H | H | H | H | H | 3-(环丙基亚磺酰基) | 1 |
C-5205 | H | H | H | H | H | 4-(环丙基亚磺酰基) | 1 |
C-5206 | H | H | H | H | H | 2-(环丙基磺酰基) | 1 |
C-5207 | H | H | H | H | H | 3-(环丙基磺酰基) | 1 |
C-5208 | H | H | H | H | H | 4-(环丙基磺酰基) | 1 |
C-5209 | H | H | H | H | H | 2-((环丙基甲基)硫基) | 1 |
C-5210 | H | H | H | H | H | 3-((环丙基甲基)硫基) | 1 |
C-5211 | H | H | H | H | H | 4-((环丙基甲基)硫基) | 1 |
C-5212 | H | H | H | H | H | 2-((环丙基甲基)亚磺酰基) | 1 |
C-5213 | H | H | H | H | H | 3-((环丙基甲基)亚磺酰基) | 1 |
C-5214 | H | H | H | H | H | 4-((环丙基甲基)亚磺酰基) | 1 |
C-5215 | H | H | H | H | H | 2-((环丙基甲基)磺酰基) | 1 |
C-5216 | H | H | H | H | H | 3-((环丙基甲基)磺酰基) | 1 |
C-5217 | H | H | H | H | H | 4-((环丙基甲基)磺酰基) | 1 |
C-5218 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)硫基) | 1 |
C-5219 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)硫基) | 1 |
C-5220 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)硫基) | 1 |
C-5221 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)亚磺酰基) | 1 |
C-5222 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)亚磺酰基) | 1 |
C-5223 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)亚磺酰基) | 1 |
[表222]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5224 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)磺酰基) | 1 |
C-5225 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)磺酰基) | 1 |
C-5226 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)磺酰基) | 1 |
C-5227 | H | H | H | H | H | 2-C(=O)Me | 1 |
C-5228 | H | H | H | H | H | 3-C(=O)Me | 1 |
C-5229 | H | H | H | H | H | 4-C(=O)Me | 1 |
C-5230 | H | H | H | H | H | 2-C(=O)Et | 1 |
C-5231 | H | H | H | H | H | 3-C(=O)Et | 1 |
C-5232 | H | H | H | H | H | 4-C(=O)Et | 1 |
C-5233 | H | H | H | H | H | 2-C(=O)CF<sub>3</sub> | 1 |
C-5234 | H | H | H | H | H | 3-C(=O)CF<sub>3</sub> | 1 |
C-5235 | H | H | H | H | H | 4-C(=O)CF<sub>3</sub> | 1 |
C-5236 | H | H | H | H | H | 2-C(=O)OMe | 1 |
C-5237 | H | H | H | H | H | 3-C(=O)OMe | 1 |
C-5238 | H | H | H | H | H | 4-C(=O)OMe | 1 |
C-5239 | H | H | H | H | H | 2-C(=O)OEt | 1 |
C-5240 | H | H | H | H | H | 3-C(=O)OEt | 1 |
C-5241 | H | H | H | H | H | 4-C(=O)OEt | 1 |
C-5242 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub> | 1 |
C-5243 | H | H | H | H | H | 3-C(=O)NH<sub>2</sub> | 1 |
C-5244 | H | H | H | H | H | 4-C(=O)NH<sub>2</sub> | 1 |
C-5245 | H | H | H | H | H | 2-C(=O)NHMe | 1 |
C-5246 | H | H | H | H | H | 3-C(=O)NHMe | 1 |
C-5247 | H | H | H | H | H | 4-C(=O)NHMe | 1 |
C-5248 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub> | 1 |
C-5249 | H | H | H | H | H | 3-C(=O)NMe<sub>2</sub> | 1 |
C-5250 | H | H | H | H | H | 4-C(=O)NMe<sub>2</sub> | 1 |
C-5251 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 1 |
C-5252 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 1 |
C-5253 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 1 |
C-5254 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 1 |
C-5255 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 1 |
C-5256 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 1 |
C-5257 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 1 |
C-5258 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 1 |
C-5259 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 1 |
C-5260 | H | H | H | H | H | 2-CH<sub>2</sub>OH | 1 |
C-5261 | H | H | H | H | H | 3-CH<sub>2</sub>OH | 1 |
C-5262 | H | H | H | H | H | 4-CH<sub>2</sub>OH | 1 |
C-5263 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 1 |
C-5264 | H | H | H | H | H | 3-CH<sub>2</sub>OCH<sub>3</sub> | 1 |
C-5265 | H | H | H | H | H | 4-CH<sub>2</sub>OCH<sub>3</sub> | 1 |
C-5266 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 1 |
C-5267 | H | H | H | H | H | 3-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 1 |
C-5268 | H | H | H | H | H | 4-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 1 |
C-5269 | H | H | H | H | H | 2-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 1 |
C-5270 | H | H | H | H | H | 3-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 1 |
C-5271 | H | H | H | H | H | 4-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 1 |
C-5272 | H | H | H | H | H | 2-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 1 |
C-5273 | H | H | H | H | H | 3-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 1 |
C-5274 | H | H | H | H | H | 4-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 1 |
C-5275 | H | H | H | H | H | 2-CH<sub>2</sub>OCF<sub>3</sub> | 1 |
C-5276 | H | H | H | H | H | 3-CH<sub>2</sub>OCF<sub>3</sub> | 1 |
C-5277 | H | H | H | H | H | 4-CH<sub>2</sub>OCF<sub>3</sub> | 1 |
C-5278 | H | H | H | H | H | 2-CF<sub>2</sub>OCH<sub>3</sub> | 1 |
C-5279 | H | H | H | H | H | 3-CF<sub>2</sub>OCH<sub>3</sub> | 1 |
C-5280 | H | H | H | H | H | 4-CF<sub>2</sub>OCH<sub>3</sub> | 1 |
[表223]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5281 | H | H | H | H | H | 2-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 1 |
C-5282 | H | H | H | H | H | 3-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 1 |
C-5283 | H | H | H | H | H | 4-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 1 |
C-5284 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub> | 1 |
C-5285 | H | H | H | H | H | 3-OC(=O)CH<sub>3</sub> | 1 |
C-5286 | H | H | H | H | H | 4-OC(=O)CH<sub>3</sub> | 1 |
C-5287 | H | H | H | H | H | 2-OC(=O)CF<sub>3</sub> | 1 |
C-5288 | H | H | H | H | H | 3-OC(=O)CF<sub>3</sub> | 1 |
C-5289 | H | H | H | H | H | 4-OC(=O)CF<sub>3</sub> | 1 |
C-5290 | H | H | H | H | H | 2-OC(=O)NH<sub>2</sub> | 1 |
C-5291 | H | H | H | H | H | 3-OC(=O)NH<sub>2</sub> | 1 |
C-5292 | H | H | H | H | H | 4-OC(=O)NH<sub>2</sub> | 1 |
C-5293 | H | H | H | H | H | 2-OC(=O)NHCH<sub>3</sub> | 1 |
C-5294 | H | H | H | H | H | 3-OC(=O)NHCH<sub>3</sub> | 1 |
C-5295 | H | H | H | H | H | 4-OC(=O)NHCH<sub>3</sub> | 1 |
C-5296 | H | H | H | H | H | 2-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
C-5297 | H | H | H | H | H | 3-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
C-5298 | H | H | H | H | H | 4-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
C-5299 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 1 |
C-5300 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 1 |
C-5301 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 1 |
C-5302 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 1 |
C-5303 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 1 |
C-5304 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 1 |
C-5305 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
C-5306 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
C-5307 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
C-5308 | H | H | H | H | H | 2-OC(=O)OCH<sub>3</sub> | 1 |
C-5309 | H | H | H | H | H | 3-OC(=O)OCH<sub>3</sub> | 1 |
C-5310 | H | H | H | H | H | 4-OC(=O)OCH<sub>3</sub> | 1 |
C-5311 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 1 |
C-5312 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 1 |
C-5313 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 1 |
C-5314 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 1 |
C-5315 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 1 |
C-5316 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 1 |
C-5317 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
C-5318 | H | H | H | H | H | 3-OS(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
C-5319 | H | H | H | H | H | 4-OS(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
C-5320 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
C-5321 | H | H | H | H | H | 3-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
C-5322 | H | H | H | H | H | 4-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
C-5323 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 1 |
C-5324 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 1 |
C-5325 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 1 |
C-5326 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
C-5327 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
C-5328 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
C-5329 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub> | 1 |
C-5330 | H | H | H | H | H | 3-CH<sub>2</sub>SCF<sub>3</sub> | 1 |
C-5331 | H | H | H | H | H | 4-CH<sub>2</sub>SCF<sub>3</sub> | 1 |
C-5332 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 1 |
C-5333 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 1 |
C-5334 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 1 |
C-5335 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
C-5336 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
C-5337 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
[表224]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5338 | H | H | H | H | H | 2-苯基 | 1 |
C-5339 | H | H | H | H | H | 3-苯基 | 1 |
C-5340 | H | H | H | H | H | 4-苯基 | 1 |
C-5341 | H | H | H | H | H | 2-(苯氧基) | 1 |
C-5342 | H | H | H | H | H | 3-(苯氧基) | 1 |
C-5343 | H | H | H | H | H | 4-(苯氧基) | 1 |
C-5344 | H | H | H | H | H | 2-苯甲基 | 1 |
C-5345 | H | H | H | H | H | 3-苯甲基 | 1 |
C-5346 | H | H | H | H | H | 4-苯甲基 | 1 |
C-5347 | H | H | H | H | H | 2-(苯甲基氧基) | 1 |
C-5348 | H | H | H | H | H | 3-(苯甲基氧基) | 1 |
C-5349 | H | H | H | H | H | 4-(苯甲基氧基) | 1 |
C-5350 | H | H | H | H | H | 2-((2-氟苯甲基)氧基) | 1 |
C-5351 | H | H | H | H | H | 3-((2-氟苯甲基)氧基) | 1 |
C-5352 | H | H | H | H | H | 4-((2-氟苯甲基)氧基) | 1 |
C-5353 | H | H | H | H | H | 2-((3-氟苯甲基)氧基) | 1 |
C-5354 | H | H | H | H | H | 3-((3-氟苯甲基)氧基) | 1 |
C-5355 | H | H | H | H | H | 4-((3-氟苯甲基)氧基) | 1 |
C-5356 | H | H | H | H | H | 2-((4-氟苯甲基)氧基) | 1 |
C-5357 | H | H | H | H | H | 3-((4-氟苯甲基)氧基) | 1 |
C-5358 | H | H | H | H | H | 4-((4-氟苯甲基)氧基) | 1 |
C-5359 | H | H | H | H | H | 2-((2-氯苯甲基)氧基) | 1 |
C-5360 | H | H | H | H | H | 3-((2-氯苯甲基)氧基) | 1 |
C-5361 | H | H | H | H | H | 4-((2-氯苯甲基)氧基) | 1 |
C-5362 | H | H | H | H | H | 2-((3-氯苯甲基)氧基) | 1 |
C-5363 | H | H | H | H | H | 3-((3-氯苯甲基)氧基) | 1 |
C-5364 | H | H | H | H | H | 4-((3-氯苯甲基)氧基) | 1 |
C-5365 | H | H | H | H | H | 2-((4-氯苯甲基)氧基) | 1 |
C-5366 | H | H | H | H | H | 3-((4-氯苯甲基)氧基) | 1 |
C-5367 | H | H | H | H | H | 4-((4-氯苯甲基)氧基) | 1 |
C-5368 | H | H | H | H | H | 2-((2-甲基苯甲基)氧基) | 1 |
C-5369 | H | H | H | H | H | 3-((2-甲基苯甲基)氧基) | 1 |
C-5370 | H | H | H | H | H | 4-((2-甲基苯甲基)氧基) | 1 |
C-5371 | H | H | H | H | H | 2-((3-甲基苯甲基)氧基) | 1 |
C-5372 | H | H | H | H | H | 3-((3-甲基苯甲基)氧基) | 1 |
C-5373 | H | H | H | H | H | 4-((3-甲基苯甲基)氧基) | 1 |
C-5374 | H | H | H | H | H | 2-((4-甲基苯甲基)氧基) | 1 |
C-5375 | H | H | H | H | H | 3-((4-甲基苯甲基)氧基) | 1 |
C-5376 | H | H | H | H | H | 4-((4-甲基苯甲基)氧基) | 1 |
C-5377 | H | H | H | H | H | 2-((2-(三氟甲基)苯甲基)氧基) | 1 |
C-5378 | H | H | H | H | H | 3-((2-(三氟甲基)苯甲基)氧基) | 1 |
C-5379 | H | H | H | H | H | 4-((2-(三氟甲基)苯甲基)氧基) | 1 |
C-5380 | H | H | H | H | H | 2-((3-(三氟甲基)苯甲基)氧基) | 1 |
C-5381 | H | H | H | H | H | 3-((3-(三氟甲基)苯甲基)氧基) | 1 |
C-5382 | H | H | H | H | H | 4-((3-(三氟甲基)苯甲基)氧基) | 1 |
C-5383 | H | H | H | H | H | 2-((4-(三氟甲基)苯甲基)氧基) | 1 |
C-5384 | H | H | H | H | H | 3-((4-(三氟甲基)苯甲基)氧基) | 1 |
C-5385 | H | H | H | H | H | 4-((4-(三氟甲基)苯甲基)氧基) | 1 |
C-5386 | H | H | H | H | H | 2-((2-甲氧基苯甲基)氧基) | 1 |
C-5387 | H | H | H | H | H | 3-((2-甲氧基苯甲基)氧基) | 1 |
C-5388 | H | H | H | H | H | 4-((2-甲氧基苯甲基)氧基) | 1 |
C-5389 | H | H | H | H | H | 2-((3-甲氧基苯甲基)氧基) | 1 |
C-5390 | H | H | H | H | H | 3-((3-甲氧基苯甲基)氧基) | 1 |
C-5391 | H | H | H | H | H | 4-((3-甲氧基苯甲基)氧基) | 1 |
C-5392 | H | H | H | H | H | 2-((4-甲氧基苯甲基)氧基) | 1 |
C-5393 | H | H | H | H | H | 3-((4-甲氧基苯甲基)氧基) | 1 |
C-5394 | H | H | H | H | H | 4-((4-甲氧基苯甲基)氧基) | 1 |
[表225]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5395 | H | H | H | H | H | 2-((2-(三氟甲氧基)苯甲基)氧基) | 1 |
C-5396 | H | H | H | H | H | 3-((2-(三氟甲氧基)苯甲基)氧基) | 1 |
C-5397 | H | H | H | H | H | 4-((2-(三氟甲氧基)苯甲基)氧基) | 1 |
C-5398 | H | H | H | H | H | 2-((3-(三氟甲氧基)苯甲基)氧基) | 1 |
C-5399 | H | H | H | H | H | 3-((3-(三氟甲氧基)苯甲基)氧基) | 1 |
C-5400 | H | H | H | H | H | 4-((3-(三氟甲氧基)苯甲基)氧基) | 1 |
C-5401 | H | H | H | H | H | 2-((4-(三氟甲氧基)苯甲基)氧基) | 1 |
C-5402 | H | H | H | H | H | 3-((4-(三氟甲氧基)苯甲基)氧基) | 1 |
C-5403 | H | H | H | H | H | 4-((4-(三氟甲氧基)苯甲基)氧基) | 1 |
C-5404 | H | H | H | H | H | 2-((2-(甲基硫基)苯甲基)氧基) | 1 |
C-5405 | H | H | H | H | H | 3-((2-(甲基硫基)苯甲基)氧基) | 1 |
C-5406 | H | H | H | H | H | 4-((2-(甲基硫基)苯甲基)氧基) | 1 |
C-5407 | H | H | H | H | H | 2-((3-(甲基硫基)苯甲基)氧基) | 1 |
C-5408 | H | H | H | H | H | 3-((3-(甲基硫基)苯甲基)氧基) | 1 |
C-5409 | H | H | H | H | H | 4-((3-(甲基硫基)苯甲基)氧基) | 1 |
C-5410 | H | H | H | H | H | 2-((4-(甲基硫基)苯甲基)氧基) | 1 |
C-5411 | H | H | H | H | H | 3-((4-(甲基硫基)苯甲基)氧基) | 1 |
C-5412 | H | H | H | H | H | 4-((4-(甲基硫基)苯甲基)氧基) | 1 |
C-5413 | H | H | H | H | H | 2-((2-(甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5414 | H | H | H | H | H | 3-((2-(甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5415 | H | H | H | H | H | 4-((2-(甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5416 | H | H | H | H | H | 2-((3-(甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5417 | H | H | H | H | H | 3-((3-(甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5418 | H | H | H | H | H | 4-((3-(甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5419 | H | H | H | H | H | 2-((4-(甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5420 | H | H | H | H | H | 3-((4-(甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5421 | H | H | H | H | H | 4-((4-(甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5422 | H | H | H | H | H | 2-((2-(甲基磺酰基)苯甲基)氧基) | 1 |
C-5423 | H | H | H | H | H | 3-((2-(甲基磺酰基)苯甲基)氧基) | 1 |
C-5424 | H | H | H | H | H | 4-((2-(甲基磺酰基)苯甲基)氧基) | 1 |
C-5425 | H | H | H | H | H | 2-((3-(甲基磺酰基)苯甲基)氧基) | 1 |
C-5426 | H | H | H | H | H | 3-((3-(甲基磺酰基)苯甲基)氧基) | 1 |
C-5427 | H | H | H | H | H | 4-((3-(甲基磺酰基)苯甲基)氧基) | 1 |
C-5428 | H | H | H | H | H | 2-((4-(甲基磺酰基)苯甲基)氧基) | 1 |
C-5429 | H | H | H | H | H | 3-((4-(甲基磺酰基)苯甲基)氧基) | 1 |
C-5430 | H | H | H | H | H | 4-((4-(甲基磺酰基)苯甲基)氧基) | 1 |
C-5431 | H | H | H | H | H | 2-((2-(三氟甲基硫基)苯甲基)氧基) | 1 |
C-5432 | H | H | H | H | H | 3-((2-(三氟甲基硫基)苯甲基)氧基) | 1 |
C-5433 | H | H | H | H | H | 4-((2-(三氟甲基硫基)苯甲基)氧基) | 1 |
C-5434 | H | H | H | H | H | 2-((3-(三氟甲基硫基)苯甲基)氧基) | 1 |
C-5435 | H | H | H | H | H | 3-((3-(三氟甲基硫基)苯甲基)氧基) | 1 |
C-5436 | H | H | H | H | H | 4-((3-(三氟甲基硫基)苯甲基)氧基) | 1 |
C-5437 | H | H | H | H | H | 2-((4-(三氟甲基硫基)苯甲基)氧基) | 1 |
C-5438 | H | H | H | H | H | 3-((4-(三氟甲基硫基)苯甲基)氧基) | 1 |
C-5439 | H | H | H | H | H | 4-((4-(三氟甲基硫基)苯甲基)氧基) | 1 |
C-5440 | H | H | H | H | H | 2-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5441 | H | H | H | H | H | 3-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5442 | H | H | H | H | H | 4-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5443 | H | H | H | H | H | 2-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5444 | H | H | H | H | H | 3-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5445 | H | H | H | H | H | 4-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5446 | H | H | H | H | H | 2-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5447 | H | H | H | H | H | 3-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5448 | H | H | H | H | H | 4-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
C-5449 | H | H | H | H | H | 2-((2-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
C-5450 | H | H | H | H | H | 3-((2-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
C-5451 | H | H | H | H | H | 4-((2-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
[表226]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5452 | H | H | H | H | H | 2-((3-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
C-5453 | H | H | H | H | H | 3-((3-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
C-5454 | H | H | H | H | H | 4-((3-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
C-5455 | H | H | H | H | H | 2-((4-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
C-5456 | H | H | H | H | H | 3-((4-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
C-5457 | H | H | H | H | H | 4-((4-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
C-5458 | H | H | H | H | H | 2-((2-氨基苯甲基)氧基) | 1 |
C-5459 | H | H | H | H | H | 3-((2-氨基苯甲基)氧基) | 1 |
C-5460 | H | H | H | H | H | 4-((2-氨基苯甲基)氧基) | 1 |
C-5461 | H | H | H | H | H | 2-((3-氨基苯甲基)氧基) | 1 |
C-5462 | H | H | H | H | H | 3-((3-氨基苯甲基)氧基) | 1 |
C-5463 | H | H | H | H | H | 4-((3-氨基苯甲基)氧基) | 1 |
C-5464 | H | H | H | H | H | 2-((4-氨基苯甲基)氧基) | 1 |
C-5465 | H | H | H | H | H | 3-((4-氨基苯甲基)氧基) | 1 |
C-5466 | H | H | H | H | H | 4-((4-氨基苯甲基)氧基) | 1 |
C-5467 | H | H | H | H | H | 2-((2-(甲基氨基)苯甲基)氧基) | 1 |
C-5468 | H | H | H | H | H | 3-((2-(甲基氨基)苯甲基)氧基) | 1 |
C-5469 | H | H | H | H | H | 4-((2-(甲基氨基)苯甲基)氧基) | 1 |
C-5470 | H | H | H | H | H | 2-((3-(甲基氨基)苯甲基)氧基) | 1 |
C-5471 | H | H | H | H | H | 3-((3-(甲基氨基)苯甲基)氧基) | 1 |
C-5472 | H | H | H | H | H | 4-((3-(甲基氨基)苯甲基)氧基) | 1 |
C-5473 | H | H | H | H | H | 2-((4-(甲基氨基)苯甲基)氧基) | 1 |
C-5474 | H | H | H | H | H | 3-((4-(甲基氨基)苯甲基)氧基) | 1 |
C-5475 | H | H | H | H | H | 4-((4-(甲基氨基)苯甲基)氧基) | 1 |
C-5476 | H | H | H | H | H | 2-((2-(二甲基氨基)苯甲基)氧基) | 1 |
C-5477 | H | H | H | H | H | 3-((2-(二甲基氨基)苯甲基)氧基) | 1 |
C-5478 | H | H | H | H | H | 4-((2-(二甲基氨基)苯甲基)氧基) | 1 |
C-5479 | H | H | H | H | H | 2-((3-(二甲基氨基)苯甲基)氧基) | 1 |
C-5480 | H | H | H | H | H | 3-((3-(二甲基氨基)苯甲基)氧基) | 1 |
C-5481 | H | H | H | H | H | 4-((3-(二甲基氨基)苯甲基)氧基) | 1 |
C-5482 | H | H | H | H | H | 2-((4-(二甲基氨基)苯甲基)氧基) | 1 |
C-5483 | H | H | H | H | H | 3-((4-(二甲基氨基)苯甲基)氧基) | 1 |
C-5484 | H | H | H | H | H | 4-((4-(二甲基氨基)苯甲基)氧基) | 1 |
C-5485 | H | H | H | H | H | 2-((2-氰基苯甲基)氧基) | 1 |
C-5486 | H | H | H | H | H | 3-((2-氰基苯甲基)氧基) | 1 |
C-5487 | H | H | H | H | H | 4-((2-氰基苯甲基)氧基) | 1 |
C-5488 | H | H | H | H | H | 2-((3-氰基苯甲基)氧基) | 1 |
C-5489 | H | H | H | H | H | 3-((3-氰基苯甲基)氧基) | 1 |
C-5490 | H | H | H | H | H | 4-((3-氰基苯甲基)氧基) | 1 |
C-5491 | H | H | H | H | H | 2-((4-氰基苯甲基)氧基) | 1 |
C-5492 | H | H | H | H | H | 3-((4-氰基苯甲基)氧基) | 1 |
C-5493 | H | H | H | H | H | 4-((4-氰基苯甲基)氧基) | 1 |
C-5494 | H | H | H | H | H | 2-((2-硝基苯甲基)氧基) | 1 |
C-5495 | H | H | H | H | H | 3-((2-硝基苯甲基)氧基) | 1 |
C-5496 | H | H | H | H | H | 4-((2-硝基苯甲基)氧基) | 1 |
C-5497 | H | H | H | H | H | 2-((3-硝基苯甲基)氧基) | 1 |
C-5498 | H | H | H | H | H | 3-((3-硝基苯甲基)氧基) | 1 |
C-5499 | H | H | H | H | H | 4-((3-硝基苯甲基)氧基) | 1 |
C-5500 | H | H | H | H | H | 2-((4-硝基苯甲基)氧基) | 1 |
C-5501 | H | H | H | H | H | 3-((4-硝基苯甲基)氧基) | 1 |
C-5502 | H | H | H | H | H | 4-((4-硝基苯甲基)氧基) | 1 |
C-5503 | H | H | H | H | H | 2-NH2 | 1 |
C-5504 | H | H | H | H | H | 3-NH2 | 1 |
C-5505 | H | H | H | H | H | 4-NH2 | 1 |
C-5506 | H | H | H | H | H | 2-NHMe | 1 |
C-5507 | H | H | H | H | H | 3-NHMe | 1 |
C-5508 | H | H | H | H | H | 4-NHMe | 1 |
[表227]
[表228]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5566 | H | H | H | H | H | 3-F,5-Cl | 1 |
C-5567 | H | H | H | H | H | 3-F,6-Cl | 1 |
C-5568 | H | H | H | H | H | 4-F,2-Cl | 1 |
C-5569 | H | H | H | H | H | 4-F,3-Cl | 1 |
C-5570 | H | H | H | H | H | 2-F,3-Me | 1 |
C-5571 | H | H | H | H | H | 2-F,4-Me | 1 |
C-5572 | H | H | H | H | H | 2-F,5-Me | 1 |
C-5573 | H | H | H | H | H | 2-F,6-Me | 1 |
C-5574 | H | H | H | H | H | 3-F,2-Me | 1 |
C-5575 | H | H | H | H | H | 3-F,4-Me | 1 |
C-5576 | H | H | H | H | H | 3-F,5-Me | 1 |
C-5577 | H | H | H | H | H | 3-F,6-Me | 1 |
C-5578 | H | H | H | H | H | 4-F,2-Me | 1 |
C-5579 | H | H | H | H | H | 4-F,3-Me | 1 |
C-5580 | H | H | H | H | H | 2-F,3-CF<sub>3</sub> | 1 |
C-5581 | H | H | H | H | H | 2-F,4-CF<sub>3</sub> | 1 |
C-5582 | H | H | H | H | H | 2-F,5-CF<sub>3</sub> | 1 |
C-5583 | H | H | H | H | H | 2-F,6-CF<sub>3</sub> | 1 |
C-5584 | H | H | H | H | H | 3-F,2-CF<sub>3</sub> | 1 |
C-5585 | H | H | H | H | H | 3-F,4-CF<sub>3</sub> | 1 |
C-5586 | H | H | H | H | H | 3-F,5-CF<sub>3</sub> | 1 |
C-5587 | H | H | H | H | H | 3-F,6-CF<sub>3</sub> | 1 |
C-5588 | H | H | H | H | H | 4-F,2-CF<sub>3</sub> | 1 |
C-5589 | H | H | H | H | H | 4-F,3-CF<sub>3</sub> | 1 |
C-5590 | H | H | H | H | H | 2-F,3-OMe | 1 |
C-5591 | H | H | H | H | H | 2-F,4-OMe | 1 |
C-5592 | H | H | H | H | H | 2-F,5-OMe | 1 |
C-5593 | H | H | H | H | H | 2-F,6-OMe | 1 |
C-5594 | H | H | H | H | H | 3-F,2-OMe | 1 |
C-5595 | H | H | H | H | H | 3-F,4-OMe | 1 |
C-5596 | H | H | H | H | H | 3-F,5-OMe | 1 |
C-5597 | H | H | H | H | H | 3-F,6-OMe | 1 |
C-5598 | H | H | H | H | H | 4-F,2-OMe | 1 |
C-5599 | H | H | H | H | H | 4-F,3-OMe | 1 |
C-5600 | H | H | H | H | H | 2,3-Cl<sub>2</sub> | 1 |
C-5601 | H | H | H | H | H | 2,4-Cl<sub>2</sub> | 1 |
C-5602 | H | H | H | H | H | 2,5-Cl<sub>2</sub> | 1 |
C-5603 | H | H | H | H | H | 2,6-Cl<sub>2</sub> | 1 |
C-5604 | H | H | H | H | H | 3,4-Cl<sub>2</sub> | 1 |
C-5605 | H | H | H | H | H | 3,5-Cl<sub>2</sub> | 1 |
C-5606 | H | H | H | H | H | 2-Cl,3-Me | 1 |
C-5607 | H | H | H | H | H | 2-Cl,4-Me | 1 |
C-5608 | H | H | H | H | H | 2-Cl,5-Me | 1 |
C-5609 | H | H | H | H | H | 2-Cl,6-Me | 1 |
C-5610 | H | H | H | H | H | 3-Cl,2-Me | 1 |
C-5611 | H | H | H | H | H | 3-Cl,4-Me | 1 |
C-5612 | H | H | H | H | H | 3-Cl,5-Me | 1 |
C-5613 | H | H | H | H | H | 3-Cl,6-Me | 1 |
C-5614 | H | H | H | H | H | 4-Cl,2-Me | 1 |
C-5615 | H | H | H | H | H | 4-Cl,3-Me | 1 |
C-5616 | H | H | H | H | H | 2-Cl,3-CF<sub>3</sub> | 1 |
C-5617 | H | H | H | H | H | 2-Cl,4-CF<sub>3</sub> | 1 |
C-5618 | H | H | H | H | H | 2-Cl,5-CF<sub>3</sub> | 1 |
C-5619 | H | H | H | H | H | 2-Cl,6-CF<sub>3</sub> | 1 |
C-5620 | H | H | H | H | H | 3-Cl,2-CF<sub>3</sub> | 1 |
C-5621 | H | H | H | H | H | 3-Cl,4-CF<sub>3</sub> | 1 |
C-5622 | H | H | H | H | H | 3-Cl,5-CF<sub>3</sub> | 1 |
[表229]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5623 | H | H | H | H | H | 3-Cl,6-CF<sub>3</sub> | 1 |
C-5624 | H | H | H | H | H | 4-Cl,2-CF<sub>3</sub> | 1 |
C-5625 | H | H | H | H | H | 4-Cl,3-CF<sub>3</sub> | 1 |
C-5626 | H | H | H | H | H | 2-Cl,3-OMe | 1 |
C-5627 | H | H | H | H | H | 2-Cl,4-OMe | 1 |
C-5628 | H | H | H | H | H | 2-Cl,5-OMe | 1 |
C-5629 | H | H | H | H | H | 2-Cl,6-OMe | 1 |
C-5630 | H | H | H | H | H | 3-Cl,2-OMe | 1 |
C-5631 | H | H | H | H | H | 3-Cl,4-OMe | 1 |
C-5632 | H | H | H | H | H | 3-Cl,5-OMe | 1 |
C-5633 | H | H | H | H | H | 3-Cl,6-OMe | 1 |
C-5634 | H | H | H | H | H | 4-Cl,2-OMe | 1 |
C-5635 | H | H | H | H | H | 4-Cl,3-OMe | 1 |
C-5636 | H | H | H | H | H | 2,3-Me<sub>2</sub> | 1 |
C-5637 | H | H | H | H | H | 2,4-Me<sub>2</sub> | 1 |
C-5638 | H | H | H | H | H | 2,5-Me<sub>2</sub> | 1 |
C-5639 | H | H | H | H | H | 2,6-Me<sub>2</sub> | 1 |
C-5640 | H | H | H | H | H | 3,4-Me<sub>2</sub> | 1 |
C-5641 | H | H | H | H | H | 3,5-Me<sub>2</sub> | 1 |
C-5642 | H | H | H | H | H | 2-Me,3-CF<sub>3</sub> | 1 |
C-5643 | H | H | H | H | H | 2-Me,4-CF<sub>3</sub> | 1 |
C-5644 | H | H | H | H | H | 2-Me,5-CF<sub>3</sub> | 1 |
C-5645 | H | H | H | H | H | 2-Me,6-CF<sub>3</sub> | 1 |
C-5646 | H | H | H | H | H | 3-Me,2-CF<sub>3</sub> | 1 |
C-5647 | H | H | H | H | H | 3-Me,4-CF<sub>3</sub> | 1 |
C-5648 | H | H | H | H | H | 3-Me,5-CF<sub>3</sub> | 1 |
C-5649 | H | H | H | H | H | 3-Me,6-CF<sub>3</sub> | 1 |
C-5650 | H | H | H | H | H | 4-Me,2-CF<sub>3</sub> | 1 |
C-5651 | H | H | H | H | H | 4-Me,3-CF<sub>3</sub> | 1 |
C-5652 | H | H | H | H | H | 2-Me,3-OMe | 1 |
C-5653 | H | H | H | H | H | 2-Me,4-OMe | 1 |
C-5654 | H | H | H | H | H | 2-Me,5-OMe | 1 |
C-5655 | H | H | H | H | H | 2-Me,6-OMe | 1 |
C-5656 | H | H | H | H | H | 3-Me,2-OMe | 1 |
C-5657 | H | H | H | H | H | 3-Me,4-OMe | 1 |
C-5658 | H | H | H | H | H | 3-Me,5-OMe | 1 |
C-5659 | H | H | H | H | H | 3-Me,6-OMe | 1 |
C-5660 | H | H | H | H | H | 4-Me,2-OMe | 1 |
C-5661 | H | H | H | H | H | 4-Me,3-OMe | 1 |
C-5662 | H | H | H | H | H | 2,3-OMe<sub>2</sub> | 1 |
C-5663 | H | H | H | H | H | 2,4-OMe<sub>2</sub> | 1 |
C-5664 | H | H | H | H | H | 2,5-OMe<sub>2</sub> | 1 |
C-5665 | H | H | H | H | H | 2,6-OMe<sub>2</sub> | 1 |
C-5666 | H | H | H | H | H | 3,4-OMe<sub>2</sub> | 1 |
C-5667 | H | H | H | H | H | 3,5-OMe<sub>2</sub> | 1 |
C-5668 | H | H | H | H | H | 2-OMe,3-CF<sub>3</sub> | 1 |
C-5669 | H | H | H | H | H | 2-OMe,4-CF<sub>3</sub> | 1 |
C-5670 | H | H | H | H | H | 2-OMe,5-CF<sub>3</sub> | 1 |
C-5671 | H | H | H | H | H | 2-OMe,6-CF<sub>3</sub> | 1 |
C-5672 | H | H | H | H | H | 3-OMe,2-CF<sub>3</sub> | 1 |
C-5673 | H | H | H | H | H | 3-OMe,4-CF<sub>3</sub> | 1 |
C-5674 | H | H | H | H | H | 3-OMe,5-CF<sub>3</sub> | 1 |
C-5675 | H | H | H | H | H | 3-OMe,6-CF<sub>3</sub> | 1 |
C-5676 | H | H | H | H | H | 4-OMe,2-CF<sub>3</sub> | 1 |
C-5677 | H | H | H | H | H | 4-OMe,3-CF<sub>3</sub> | 1 |
C-5678 | H | H | H | H | H | 2-CHF<sub>2</sub>,3-F | 1 |
C-5679 | H | H | H | H | H | 2-CHF<sub>2</sub>,4-F | 1 |
[表230]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5680 | H | H | H | H | H | 2-CHF<sub>2</sub>,5-F | 1 |
C-5681 | H | H | H | H | H | 2-CHF<sub>2</sub>,6-F | 1 |
C-5682 | H | H | H | H | H | 2-CHF<sub>2</sub>,3-Me | 1 |
C-5683 | H | H | H | H | H | 2-CHF<sub>2</sub>,4-Me | 1 |
C-5684 | H | H | H | H | H | 2-CHF<sub>2</sub>,5-Me | 1 |
C-5685 | H | H | H | H | H | 2-CHF<sub>2</sub>,6-Me | 1 |
C-5686 | H | H | H | H | H | 2-环丙基,3-F | 1 |
C-5687 | H | H | H | H | H | 2-环丙基,4-F | 1 |
C-5688 | H | H | H | H | H | 2-环丙基,5-F | 1 |
C-5689 | H | H | H | H | H | 2-环丙基,6-F | 1 |
C-5690 | H | H | H | H | H | 2-环丙基,3-Me | 1 |
C-5691 | H | H | H | H | H | 2-环丙基,4-Me | 1 |
C-5692 | H | H | H | H | H | 2-环丙基,5-Me | 1 |
C-5693 | H | H | H | H | H | 2-环丙基,6-Me | 1 |
C-5694 | H | H | H | H | H | 2-乙烯基,3-F | 1 |
C-5695 | H | H | H | H | H | 2-乙烯基,4-F | 1 |
C-5696 | H | H | H | H | H | 2-乙烯基,5-F | 1 |
C-5697 | H | H | H | H | H | 2-乙烯基,6-F | 1 |
C-5698 | H | H | H | H | H | 2-乙烯基,3-Me | 1 |
C-5699 | H | H | H | H | H | 2-乙烯基,4-Me | 1 |
C-5700 | H | H | H | H | H | 2-乙烯基,5-Me | 1 |
C-5701 | H | H | H | H | H | 2-乙烯基,6-Me | 1 |
C-5702 | H | H | H | H | H | 2-OEt,3-F | 1 |
C-5703 | H | H | H | H | H | 2-OEt,4-F | 1 |
C-5704 | H | H | H | H | H | 2-OEt,5-F | 1 |
C-5705 | H | H | H | H | H | 2-OEt,6-F | 1 |
C-5706 | H | H | H | H | H | 2-OEt,3-Cl | 1 |
C-5707 | H | H | H | H | H | 2-OEt,4-Cl | 1 |
C-5708 | H | H | H | H | H | 2-OEt,5-Cl | 1 |
C-5709 | H | H | H | H | H | 2-OEt,6-Cl | 1 |
C-5710 | H | H | H | H | H | 2-OEt,3-Me | 1 |
C-5711 | H | H | H | H | H | 2-OEt,4-Me | 1 |
C-5712 | H | H | H | H | H | 2-OEt,5-Me | 1 |
C-5713 | H | H | H | H | H | 2-OEt,6-Me | 1 |
C-5714 | H | H | H | H | H | 2-OPr,3-F | 1 |
C-5715 | H | H | H | H | H | 2-OPr,4-F | 1 |
C-5716 | H | H | H | H | H | 2-OPr,5-F | 1 |
C-5717 | H | H | H | H | H | 2-OPr,6-F | 1 |
C-5718 | H | H | H | H | H | 2-OPr,3-Me | 1 |
C-5719 | H | H | H | H | H | 2-OPr,4-Me | 1 |
C-5720 | H | H | H | H | H | 2-OPr,5-Me | 1 |
C-5721 | H | H | H | H | H | 2-OPr,6-Me | 1 |
C-5722 | H | H | H | H | H | 2-O(i-Pr),3-F | 1 |
C-5723 | H | H | H | H | H | 2-O(i-Pr),4-F | 1 |
C-5724 | H | H | H | H | H | 2-O(i-Pr),5-F | 1 |
C-5725 | H | H | H | H | H | 2-O(i-Pr),6-F | 1 |
C-5726 | H | H | H | H | H | 2-O(i-Pr),3-Me | 1 |
C-5727 | H | H | H | H | H | 2-O(i-Pr),4-Me | 1 |
C-5728 | H | H | H | H | H | 2-O(i-Pr),5-Me | 1 |
C-5729 | H | H | H | H | H | 2-O(i-Pr),6-Me | 1 |
C-5730 | H | H | H | H | H | 2-OCF<sub>3</sub>,3-F | 1 |
C-5731 | H | H | H | H | H | 2-OCF<sub>3</sub>,4-F | 1 |
C-5732 | H | H | H | H | H | 2-OCF<sub>3</sub>,5-F | 1 |
C-5733 | H | H | H | H | H | 2-OCF<sub>3</sub>,6-F | 1 |
C-5734 | H | H | H | H | H | 2-OCF<sub>3</sub>,3-Me | 1 |
C-5735 | H | H | H | H | H | 2-OCF<sub>3</sub>,4-Me | 1 |
C-5736 | H | H | H | H | H | 2-OCF<sub>3</sub>,5-Me | 1 |
[表231]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5737 | H | H | H | H | H | 2-OCF<sub>3</sub>,6-Me | 1 |
C-5738 | H | H | H | H | H | 2-OCHF<sub>2</sub>,3-F | 1 |
C-5739 | H | H | H | H | H | 2-OCHF<sub>2</sub>,4-F | 1 |
C-5740 | H | H | H | H | H | 2-OCHF<sub>2</sub>,5-F | 1 |
C-5741 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-F | 1 |
C-5742 | H | H | H | H | H | 2-OCHF<sub>2</sub>,3-Me | 1 |
C-5743 | H | H | H | H | H | 2-OCHF<sub>2</sub>,4-Me | 1 |
C-5744 | H | H | H | H | H | 2-OCHF<sub>2</sub>,5-Me | 1 |
C-5745 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-Me | 1 |
C-5746 | H | H | H | H | H | 2-(环丙基氧基),3-F | 1 |
C-5747 | H | H | H | H | H | 2-(环丙基氧基),4-F | 1 |
C-5748 | H | H | H | H | H | 2-(环丙基氧基),5-F | 1 |
C-5749 | H | H | H | H | H | 2-(环丙基氧基),6-F | 1 |
C-5750 | H | H | H | H | H | 2-(环丙基氧基),3-Me | 1 |
C-5751 | H | H | H | H | H | 2-(环丙基氧基),4-Me | 1 |
C-5752 | H | H | H | H | H | 2-(环丙基氧基),5-Me | 1 |
C-5753 | H | H | H | H | H | 2-(环丙基氧基),6-Me | 1 |
C-5754 | H | H | H | H | H | 2-(环氧乙烷-2-基),3-F | 1 |
C-5755 | H | H | H | H | H | 2-(环氧乙烷-2-基),4-F | 1 |
C-5756 | H | H | H | H | H | 2-(环氧乙烷-2-基),5-F | 1 |
C-5757 | H | H | H | H | H | 2-(环氧乙烷-2-基),6-F | 1 |
C-5758 | H | H | H | H | H | 2-(环氧乙烷-2-基),3-Me | 1 |
C-5759 | H | H | H | H | H | 2-(环氧乙烷-2-基),4-Me | 1 |
C-5760 | H | H | H | H | H | 2-(环氧乙烷-2-基),5-Me | 1 |
C-5761 | H | H | H | H | H | 2-(环氧乙烷-2-基),6-Me | 1 |
C-5762 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),3-F | 1 |
C-5763 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),4-F | 1 |
C-5764 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),5-F | 1 |
C-5765 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),6-F | 1 |
C-5766 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),3-Me | 1 |
C-5767 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),4-Me | 1 |
C-5768 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),5-Me | 1 |
C-5769 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),6-Me | 1 |
C-5770 | H | H | H | H | H | 2-SMe,3-F | 1 |
C-5771 | H | H | H | H | H | 2-SMe,4-F | 1 |
C-5772 | H | H | H | H | H | 2-SMe,5-F | 1 |
C-5773 | H | H | H | H | H | 2-SMe,6-F | 1 |
C-5774 | H | H | H | H | H | 2-SMe,3-Me | 1 |
C-5775 | H | H | H | H | H | 2-SMe,4-Me | 1 |
C-5776 | H | H | H | H | H | 2-SMe,5-Me | 1 |
C-5777 | H | H | H | H | H | 2-SMe,6-Me | 1 |
C-5778 | H | H | H | H | H | 2-SEt,3-F | 1 |
C-5779 | H | H | H | H | H | 2-SEt,4-F | 1 |
C-5780 | H | H | H | H | H | 2-SEt,5-F | 1 |
C-5781 | H | H | H | H | H | 2-SEt,6-F | 1 |
C-5782 | H | H | H | H | H | 2-SEt,3-Me | 1 |
C-5783 | H | H | H | H | H | 2-SEt,4-Me | 1 |
C-5784 | H | H | H | H | H | 2-SEt,5-Me | 1 |
C-5785 | H | H | H | H | H | 2-SEt,6-Me | 1 |
C-5786 | H | H | H | H | H | 2-S(=O)Me,3-F | 1 |
C-5787 | H | H | H | H | H | 2-S(=O)Me,4-F | 1 |
C-5788 | H | H | H | H | H | 2-S(=O)Me,5-F | 1 |
C-5789 | H | H | H | H | H | 2-S(=O)Me,6-F | 1 |
C-5790 | H | H | H | H | H | 3-S(=O)Me,2-F | 1 |
C-5791 | H | H | H | H | H | 3-S(=O)Me,4-F | 1 |
C-5792 | H | H | H | H | H | 3-S(=O)Me,5-F | 1 |
C-5793 | H | H | H | H | H | 3-S(=O)Me,6-F | 1 |
[表232]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5794 | H | H | H | H | H | 2-S(=O)Me,3-Me | 1 |
C-5795 | H | H | H | H | H | 2-S(=O)Me,4-Me | 1 |
C-5796 | H | H | H | H | H | 2-S(=O)Me,5-Me | 1 |
C-5797 | H | H | H | H | H | 2-S(=O)Me,6-Me | 1 |
C-5798 | H | H | H | H | H | 3-S(=O)Me,2-Me | 1 |
C-5799 | H | H | H | H | H | 3-S(=O)Me,4-Me | 1 |
C-5800 | H | H | H | H | H | 3-S(=O)Me,5-Me | 1 |
C-5801 | H | H | H | H | H | 3-S(=O)Me,6-Me | 1 |
C-5802 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,3-F | 1 |
C-5803 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,4-F | 1 |
C-5804 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,5-F | 1 |
C-5805 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,6-F | 1 |
C-5806 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,3-Me | 1 |
C-5807 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,4-Me | 1 |
C-5808 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,5-Me | 1 |
C-5809 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,6-Me | 1 |
C-5810 | H | H | H | H | H | 2-SCF<sub>3</sub>,3-F | 1 |
C-5811 | H | H | H | H | H | 2-SCF<sub>3</sub>,4-F | 1 |
C-5812 | H | H | H | H | H | 2-SCF<sub>3</sub>,5-F | 1 |
C-5813 | H | H | H | H | H | 2-SCF<sub>3</sub>,6-F | 1 |
C-5814 | H | H | H | H | H | 2-SCF<sub>3</sub>,3-Me | 1 |
C-5815 | H | H | H | H | H | 2-SCF<sub>3</sub>,4-Me | 1 |
C-5816 | H | H | H | H | H | 2-SCF<sub>3</sub>,5-Me | 1 |
C-5817 | H | H | H | H | H | 2-SCF<sub>3</sub>,6-Me | 1 |
C-5818 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,3-F | 1 |
C-5819 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,4-F | 1 |
C-5820 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,5-F | 1 |
C-5821 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,6-F | 1 |
C-5822 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,3-Me | 1 |
C-5823 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,4-Me | 1 |
C-5824 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,5-Me | 1 |
C-5825 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,6-Me | 1 |
C-5826 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-F | 1 |
C-5827 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-F | 1 |
C-5828 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 1 |
C-5829 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 1 |
C-5830 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-Me | 1 |
C-5831 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-Me | 1 |
C-5832 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 1 |
C-5833 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 1 |
C-5834 | H | H | H | H | H | 2-(环丙基硫基),3-F | 1 |
C-5835 | H | H | H | H | H | 2-(环丙基硫基),4-F | 1 |
C-5836 | H | H | H | H | H | 2-(环丙基硫基),5-F | 1 |
C-5837 | H | H | H | H | H | 2-(环丙基硫基),6-F | 1 |
C-5838 | H | H | H | H | H | 2-(环丙基硫基),3-Me | 1 |
C-5839 | H | H | H | H | H | 2-(环丙基硫基),4-Me | 1 |
C-5840 | H | H | H | H | H | 2-(环丙基硫基),5-Me | 1 |
C-5841 | H | H | H | H | H | 2-(环丙基硫基),6-Me | 1 |
C-5842 | H | H | H | H | H | 2-C(=O)Me,3-F | 1 |
C-5843 | H | H | H | H | H | 2-C(=O)Me,4-F | 1 |
C-5844 | H | H | H | H | H | 2-C(=O)Me,5-F | 1 |
C-5845 | H | H | H | H | H | 2-C(=O)Me,6-F | 1 |
C-5846 | H | H | H | H | H | 2-C(=O)Me,3-Me | 1 |
C-5847 | H | H | H | H | H | 2-C(=O)Me,4-Me | 1 |
C-5848 | H | H | H | H | H | 2-C(=O)Me,5-Me | 1 |
C-5849 | H | H | H | H | H | 2-C(=O)Me,6-Me | 1 |
C-5850 | H | H | H | H | H | 3-C(=O)Me,2-F | 1 |
[表233]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5851 | H | H | H | H | H | 3-C(=O)Me,4-F | 1 |
C-5852 | H | H | H | H | H | 3-C(=O)Me,5-F | 1 |
C-5853 | H | H | H | H | H | 3-C(=O)Me,6-F | 1 |
C-5854 | H | H | H | H | H | 3-C(=O)Me,2-Me | 1 |
C-5855 | H | H | H | H | H | 3-C(=O)Me,4-Me | 1 |
C-5856 | H | H | H | H | H | 3-C(=O)Me,5-Me | 1 |
C-5857 | H | H | H | H | H | 3-C(=O)Me,6-Me | 1 |
C-5858 | H | H | H | H | H | 2-C(=O)OMe,3-F | 1 |
C-5859 | H | H | H | H | H | 2-C(=O)OMe,4-F | 1 |
C-5860 | H | H | H | H | H | 2-C(=O)OMe,5-F | 1 |
C-5861 | H | H | H | H | H | 2-C(=O)OMe,6-F | 1 |
C-5862 | H | H | H | H | H | 2-C(=O)OMe,3-Me | 1 |
C-5863 | H | H | H | H | H | 2-C(=O)OMe,4-Me | 1 |
C-5864 | H | H | H | H | H | 2-C(=O)OMe,5-Me | 1 |
C-5865 | H | H | H | H | H | 2-C(=O)OMe,6-Me | 1 |
C-5866 | H | H | H | H | H | 2-C(=O)OEt,3-F | 1 |
C-5867 | H | H | H | H | H | 2-C(=O)OEt,4-F | 1 |
C-5868 | H | H | H | H | H | 2-C(=O)OEt,5-F | 1 |
C-5869 | H | H | H | H | H | 2-C(=O)OEt,6-F | 1 |
C-5870 | H | H | H | H | H | 2-C(=O)OEt,3-Me | 1 |
C-5871 | H | H | H | H | H | 2-C(=O)OEt,4-Me | 1 |
C-5872 | H | H | H | H | H | 2-C(=O)OEt,5-Me | 1 |
C-5873 | H | H | H | H | H | 2-C(=O)OEt,6-Me | 1 |
C-5874 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,3-F | 1 |
C-5875 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,4-F | 1 |
C-5876 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,5-F | 1 |
C-5877 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,6-F | 1 |
C-5878 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,3-Me | 1 |
C-5879 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,4-Me | 1 |
C-5880 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,5-Me | 1 |
C-5881 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,6-Me | 1 |
C-5882 | H | H | H | H | H | 2-C(=O)NHMe,3-F | 1 |
C-5883 | H | H | H | H | H | 2-C(=O)NHMe,4-F | 1 |
C-5884 | H | H | H | H | H | 2-C(=O)NHMe,5-F | 1 |
C-5885 | H | H | H | H | H | 2-C(=O)NHMe,6-F | 1 |
C-5886 | H | H | H | H | H | 2-C(=O)NHMe,3-Me | 1 |
C-5887 | H | H | H | H | H | 2-C(=O)NHMe,4-Me | 1 |
C-5888 | H | H | H | H | H | 2-C(=O)NHMe,5-Me | 1 |
C-5889 | H | H | H | H | H | 2-C(=O)NHMe,6-Me | 1 |
C-5890 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,3-F | 1 |
C-5891 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,4-F | 1 |
C-5892 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,5-F | 1 |
C-5893 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,6-F | 1 |
C-5894 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,3-Me | 1 |
C-5895 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,4-Me | 1 |
C-5896 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,5-Me | 1 |
C-5897 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,6-Me | 1 |
C-5898 | H | H | H | H | H | 2-CH<sub>2</sub>OH,3-F | 1 |
C-5899 | H | H | H | H | H | 2-CH<sub>2</sub>OH,4-F | 1 |
C-5900 | H | H | H | H | H | 2-CH<sub>2</sub>OH,5-F | 1 |
C-5901 | H | H | H | H | H | 2-CH<sub>2</sub>OH,6-F | 1 |
C-5902 | H | H | H | H | H | 2-CH<sub>2</sub>OH,3-Me | 1 |
C-5903 | H | H | H | H | H | 2-CH<sub>2</sub>OH,4-Me | 1 |
C-5904 | H | H | H | H | H | 2-CH<sub>2</sub>OH,5-Me | 1 |
C-5905 | H | H | H | H | H | 2-CH<sub>2</sub>OH,6-Me | 1 |
C-5906 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-F | 1 |
C-5907 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 1 |
[表234]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5908 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 1 |
C-5909 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 1 |
C-5910 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-Me | 1 |
C-5911 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 1 |
C-5912 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 1 |
C-5913 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 1 |
C-5914 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-F | 1 |
C-5915 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-F | 1 |
C-5916 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-F | 1 |
C-5917 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-F | 1 |
C-5918 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-Me | 1 |
C-5919 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-Me | 1 |
C-5920 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-Me | 1 |
C-5921 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Me | 1 |
C-5922 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,3-F | 1 |
C-5923 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,4-F | 1 |
C-5924 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,5-F | 1 |
C-5925 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,6-F | 1 |
C-5926 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,3-Me | 1 |
C-5927 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,4-Me | 1 |
C-5928 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 1 |
C-5929 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 1 |
C-5930 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-F | 1 |
C-5931 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-F | 1 |
C-5932 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 1 |
C-5933 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 1 |
C-5934 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-Me | 1 |
C-5935 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-Me | 1 |
C-5936 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 1 |
C-5937 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 1 |
C-5938 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-F | 1 |
C-5939 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-F | 1 |
C-5940 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 1 |
C-5941 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 1 |
C-5942 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-Me | 1 |
C-5943 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-Me | 1 |
C-5944 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 1 |
C-5945 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 1 |
C-5946 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-F | 1 |
C-5947 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-F | 1 |
C-5948 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-F | 1 |
C-5949 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-F | 1 |
C-5950 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-Me | 1 |
C-5951 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-Me | 1 |
C-5952 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-Me | 1 |
C-5953 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-Me | 1 |
C-5954 | H | H | H | H | H | 2-(苯甲基氧基),3-F | 1 |
C-5955 | H | H | H | H | H | 2-(苯甲基氧基),4-F | 1 |
C-5956 | H | H | H | H | H | 2-(苯甲基氧基),5-F | 1 |
C-5957 | H | H | H | H | H | 2-(苯甲基氧基),6-F | 1 |
C-5958 | H | H | H | H | H | 2-(苯甲基氧基),3-Me | 1 |
C-5959 | H | H | H | H | H | 2-(苯甲基氧基),4-Me | 1 |
C-5960 | H | H | H | H | H | 2-(苯甲基氧基),5-Me | 1 |
C-5961 | H | H | H | H | H | 2-(苯甲基氧基),6-Me | 1 |
C-5962 | H | H | H | H | H | 2-NH<sub>2</sub>,3-F | 1 |
C-5963 | H | H | H | H | H | 2-NH<sub>2</sub>,4-F | 1 |
C-5964 | H | H | H | H | H | 2-NH<sub>2</sub>,5-F | 1 |
[表235]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-5965 | H | H | H | H | H | 2-NH<sub>2</sub>,6-F | 1 |
C-5966 | H | H | H | H | H | 2-NH<sub>2</sub>,3-Me | 1 |
C-5967 | H | H | H | H | H | 2-NH<sub>2</sub>,4-Me | 1 |
C-5968 | H | H | H | H | H | 2-NH<sub>2</sub>,5-Me | 1 |
C-5969 | H | H | H | H | H | 2-NH<sub>2</sub>,6-Me | 1 |
C-5970 | H | H | H | H | H | 2-NHMe,3-F | 1 |
C-5971 | H | H | H | H | H | 2-NHMe,4-F | 1 |
C-5972 | H | H | H | H | H | 2-NHMe,5-F | 1 |
C-5973 | H | H | H | H | H | 2-NHMe,6-F | 1 |
C-5974 | H | H | H | H | H | 2-NHMe,3-Me | 1 |
C-5975 | H | H | H | H | H | 2-NHMe,4-Me | 1 |
C-5976 | H | H | H | H | H | 2-NHMe,5-Me | 1 |
C-5977 | H | H | H | H | H | 2-NHMe,6-Me | 1 |
C-5978 | H | H | H | H | H | 2-NHEt,3-F | 1 |
C-5979 | H | H | H | H | H | 2-NHEt,4-F | 1 |
C-5980 | H | H | H | H | H | 2-NHEt,5-F | 1 |
C-5981 | H | H | H | H | H | 2-NHEt,6-F | 1 |
C-5982 | H | H | H | H | H | 2-NHEt,3-Me | 1 |
C-5983 | H | H | H | H | H | 2-NHEt,4-Me | 1 |
C-5984 | H | H | H | H | H | 2-NHEt,5-Me | 1 |
C-5985 | H | H | H | H | H | 2-NHEt,6-Me | 1 |
C-5986 | H | H | H | H | H | 2-NMe<sub>2</sub>,3-F | 1 |
C-5987 | H | H | H | H | H | 2-NMe<sub>2</sub>,4-F | 1 |
C-5988 | H | H | H | H | H | 2-NMe<sub>2</sub>,5-F | 1 |
C-5989 | H | H | H | H | H | 2-NMe<sub>2</sub>,6-F | 1 |
C-5990 | H | H | H | H | H | 2-NMe<sub>2</sub>,3-Me | 1 |
C-5991 | H | H | H | H | H | 2-NMe<sub>2</sub>,4-Me | 1 |
C-5992 | H | H | H | H | H | 2-NMe<sub>2</sub>,5-Me | 1 |
C-5993 | H | H | H | H | H | 2-NMe<sub>2</sub>,6-Me | 1 |
C-5994 | H | H | H | H | H | 2-NEt<sub>2</sub>,3-F | 1 |
C-5995 | H | H | H | H | H | 2-NEt<sub>2</sub>,4-F | 1 |
C-5996 | H | H | H | H | H | 2-NEt<sub>2</sub>,5-F | 1 |
C-5997 | H | H | H | H | H | 2-NEt<sub>2</sub>,6-F | 1 |
C-5998 | H | H | H | H | H | 2-NEt<sub>2</sub>,3-Me | 1 |
C-5999 | H | H | H | H | H | 2-NEt<sub>2</sub>,4-Me | 1 |
C-6000 | H | H | H | H | H | 2-NEt<sub>2</sub>,5-Me | 1 |
C-6001 | H | H | H | H | H | 2-NEt<sub>2</sub>,6-Me | 1 |
C-6002 | H | H | H | H | H | 2-CHO,3-F | 1 |
C-6003 | H | H | H | H | H | 2-CHO,4-F | 1 |
C-6004 | H | H | H | H | H | 2-CHO,5-F | 1 |
C-6005 | H | H | H | H | H | 2-CHO,6-F | 1 |
C-6006 | H | H | H | H | H | 2-CHO,3-Me | 1 |
C-6007 | H | H | H | H | H | 2-CHO,4-Me | 1 |
C-6008 | H | H | H | H | H | 2-CHO,5-Me | 1 |
C-6009 | H | H | H | H | H | 2-CHO,6-Me | 1 |
C-6010 | H | H | H | H | H | 2-C(=O)OH,3-F | 1 |
C-6011 | H | H | H | H | H | 2-C(=O)OH,4-F | 1 |
C-6012 | H | H | H | H | H | 2-C(=O)OH,5-F | 1 |
C-6013 | H | H | H | H | H | 2-C(=O)OH,6-F | 1 |
C-6014 | H | H | H | H | H | 2-C(=O)OH,3-Me | 1 |
C-6015 | H | H | H | H | H | 2-C(=O)OH,4-Me | 1 |
C-6016 | H | H | H | H | H | 2-C(=O)OH,5-Me | 1 |
C-6017 | H | H | H | H | H | 2-C(=O)OH,6-Me | 1 |
C-6018 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),3-F | 1 |
C-6019 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),4-F | 1 |
C-6020 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),5-F | 1 |
C-6021 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),6-F | 1 |
[表236]
[表237]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-6079 | H | H | H | H | H | 2-CN,4-OMe | 1 |
C-6080 | H | H | H | H | H | 2-CN,5-OMe | 1 |
C-6081 | H | H | H | H | H | 2-CN,6-OMe | 1 |
C-6082 | H | H | H | H | H | 3-CN,2-F | 1 |
C-6083 | H | H | H | H | H | 3-CN,4-F | 1 |
C-6084 | H | H | H | H | H | 3-CN,5-F | 1 |
C-6085 | H | H | H | H | H | 3-CN,6-F | 1 |
C-6086 | H | H | H | H | H | 3-CN,2-Cl | 1 |
C-6087 | H | H | H | H | H | 3-CN,4-Cl | 1 |
C-6088 | H | H | H | H | H | 3-CN,5-Cl | 1 |
C-6089 | H | H | H | H | H | 3-CN,6-Cl | 1 |
C-6090 | H | H | H | H | H | 3-CN,2-Me | 1 |
C-6091 | H | H | H | H | H | 3-CN,4-Me | 1 |
C-6092 | H | H | H | H | H | 3-CN,5-Me | 1 |
C-6093 | H | H | H | H | H | 3-CN,6-Me | 1 |
C-6094 | H | H | H | H | H | 3-CN,2-OMe | 1 |
C-6095 | H | H | H | H | H | 3-CN,4-OMe | 1 |
C-6096 | H | H | H | H | H | 3-CN,5-OMe | 1 |
C-6097 | H | H | H | H | H | 3-CN,6-OMe | 1 |
C-6098 | H | H | H | H | H | 4-CN,2-F | 1 |
C-6099 | H | H | H | H | H | 4-CN,3-F | 1 |
C-6100 | H | H | H | H | H | 4-CN,2-Cl | 1 |
C-6101 | H | H | H | H | H | 4-CN,3-Cl | 1 |
C-6102 | H | H | H | H | H | 4-CN,2-Me | 1 |
C-6103 | H | H | H | H | H | 4-CN,3-Me | 1 |
C-6104 | H | H | H | H | H | 4-CN,2-OMe | 1 |
C-6105 | H | H | H | H | H | 4-CN,3-OMe | 1 |
C-6106 | H | H | H | H | H | 2-NO<sub>2</sub>,3-F | 1 |
C-6107 | H | H | H | H | H | 2-NO<sub>2</sub>,4-F | 1 |
C-6108 | H | H | H | H | H | 2-NO<sub>2</sub>,5-F | 1 |
C-6109 | H | H | H | H | H | 2-NO<sub>2</sub>,6-F | 1 |
C-6110 | H | H | H | H | H | 2-NO<sub>2</sub>,3-Me | 1 |
C-6111 | H | H | H | H | H | 2-NO<sub>2</sub>,4-Me | 1 |
C-6112 | H | H | H | H | H | 2-NO<sub>2</sub>,5-Me | 1 |
C-6113 | H | H | H | H | H | 2-NO<sub>2</sub>,6-Me | 1 |
C-6114 | H | H | H | H | H | 2-Me,3,4-F<sub>2</sub> | 1 |
C-6115 | H | H | H | H | H | 2-Me,3,5-F<sub>2</sub> | 1 |
C-6116 | H | H | H | H | H | 2-Me,3,6-F<sub>2</sub> | 1 |
C-6117 | H | H | H | H | H | 2-Me,4,5-F<sub>2</sub> | 1 |
C-6118 | H | H | H | H | H | 2-OMe,3,4-F<sub>2</sub> | 1 |
C-6119 | H | H | H | H | H | 2-OMe,3,5-F<sub>2</sub> | 1 |
C-6120 | H | H | H | H | H | 2-OMe,3,6-F<sub>2</sub> | 1 |
C-6121 | H | H | H | H | H | 2-OMe,4,5-F<sub>2</sub> | 1 |
C-6122 | H | H | H | H | H | 2-(CH<sub>2</sub>)<sub>3</sub>-3 | 1 |
C-6123 | H | H | H | H | H | 2-(CH<sub>2</sub>)<sub>4</sub>-3 | 1 |
C-6124 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>)-3 | 1 |
C-6125 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-3 | 1 |
C-6126 | H | H | H | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>O)-3 | 1 |
C-6127 | H | H | H | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-3 | 1 |
C-6128 | H | H | H | H | H | 3-(CH<sub>2</sub>)<sub>3</sub>-4 | 1 |
C-6129 | H | H | H | H | H | 3-(CH<sub>2</sub>)<sub>4</sub>-4 | 1 |
C-6130 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>)-4 | 1 |
C-6131 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-4 | 1 |
C-6132 | H | H | H | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>O)-4 | 1 |
C-6133 | H | H | H | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-4 | 1 |
C-6134 | H | H | H | H | H | 2-(OCH<sub>2</sub>O)-3 | 1 |
C-6135 | H | H | H | H | H | 3-(OCH<sub>2</sub>O)-4 | 1 |
[表238]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-6136 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>O)-3 | 1 |
C-6137 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>O)-4 | 1 |
C-6138 | H | H | H | H | H | 2-(OCF<sub>2</sub>O)-3 | 1 |
C-6139 | H | H | H | H | H | 3-(OCF<sub>2</sub>O)-4 | 1 |
C-6140 | H | H | H | H | H | 2-Me,6-Et | 1 |
C-6141 | H | H | H | H | H | 2-Me,4,5-F<sub>2</sub> | 1 |
C-6142 | H | H | H | H | H | 2-环丙基,6-OMe | 1 |
C-6143 | H | H | H | H | H | 2-Me,5-Et | 1 |
C-6144 | H | H | H | H | H | 2,6-Et<sub>2</sub> | 1 |
C-6145 | H | H | H | H | H | 2-Et,6-F | 1 |
C-6146 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 1 |
C-6147 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 1 |
C-6148 | H | H | H | H | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 1 |
C-6149 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-OMe | 1 |
C-6150 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-OMe | 1 |
C-6151 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-CN | 1 |
C-6152 | H | H | H | H | H | 2-OEt,6-CN | 1 |
C-6153 | H | H | H | H | H | 2-OEt,6-OMe | 1 |
C-6154 | H | H | H | H | H | 2,6-OEt<sub>2</sub> | 1 |
C-6155 | H | H | H | H | H | 2-CN,6-环丙基 | 1 |
C-6156 | H | H | H | H | H | 2-MeO,3-Me,6-MeO | 1 |
C-6157 | H | H | H | H | H | 2-MeO,4-Me,6-MeO | 1 |
C-6158 | H | H | H | H | H | 2-MeO,3-F,6-MeO | 1 |
C-6159 | H | H | H | H | H | 2-MeO,4-F,6-MeO | 1 |
C-6160 | H | H | H | H | H | 2-Et,6-OEt | 1 |
C-6161 | H | H | H | H | H | 2-环丙基,6-OEt | 1 |
C-6162 | H | H | H | H | H | 2,6-SMe<sub>2</sub> | 1 |
C-6163 | H | H | H | H | H | 2-NO<sub>2</sub>,6-OMe | 1 |
C-6164 | H | H | H | H | H | 2-NO<sub>2</sub>,6-CN | 1 |
C-6165 | H | H | H | H | H | 2-Cl,6-NO<sub>2</sub> | 1 |
C-6166 | H | H | H | H | H | 2-Cl,6-SMe | 1 |
C-6167 | H | H | H | H | H | 2-Cl,6-Et | 1 |
C-6168 | H | H | H | H | H | 2-CN,6-SMe | 1 |
C-6169 | H | H | H | H | H | 2,6-CN<sub>2</sub> | 1 |
C-6170 | H | H | H | H | H | 2-OMe,6-OCF<sub>3</sub> | 1 |
C-6171 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-OMe | 1 |
C-6172 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-OMe | 1 |
C-6173 | H | H | H | H | H | 2-Cl,6-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
C-6174 | H | H | H | H | H | 2-CN,6-Et | 1 |
C-6175 | H | H | H | H | H | 2-Et,6-OMe | 1 |
C-6176 | H | H | H | H | H | 2-(吡啶-2-基) | 1 |
C-6177 | H | H | H | H | H | 3-(吡啶-2-基) | 1 |
C-6178 | H | H | H | H | H | 4-(吡啶-2-基) | 1 |
C-6179 | H | H | H | H | H | 2-(嘧啶-2-基) | 1 |
C-6180 | H | H | H | H | H | 3-(嘧啶-2-基) | 1 |
C-6181 | H | H | H | H | H | 4-(嘧啶-2-基) | 1 |
C-6182 | H | H | H | H | H | 2-(吡嗪-2-基) | 1 |
C-6183 | H | H | H | H | H | 3-(吡嗪-2-基) | 1 |
C-6184 | H | H | H | H | H | 4-(吡嗪-2-基) | 1 |
C-6185 | H | H | H | H | H | 2-(1,3,5-三嗪-2-基) | 1 |
C-6186 | H | H | H | H | H | 3-(1,3,5-三嗪-2-基) | 1 |
C-6187 | H | H | H | H | H | 4-(1,3,5-三嗪-2-基) | 1 |
C-6188 | H | H | H | H | H | 2-(1,2,4-三嗪-3-基) | 1 |
C-6189 | H | H | H | H | H | 3-(1,2,4-三嗪-3-基) | 1 |
C-6190 | H | H | H | H | H | 4-(1,2,4-三嗪-3-基) | 1 |
C-6191 | H | H | H | H | H | 2-(1,2,4-三嗪-6-基) | 1 |
C-6192 | H | H | H | H | H | 3-(1,2,4-三嗪-6-基) | 1 |
[表239]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
C-6193 | H | H | H | H | H | 4-(1,2,4-三嗪-6-基) | 1 |
C-6194 | H | H | H | H | H | 2-(1H-吡唑-1-基) | 1 |
C-6195 | H | H | H | H | H | 3-(1H-吡唑-1-基) | 1 |
C-6196 | H | H | H | H | H | 4-(1H-吡唑-1-基) | 1 |
[表240]
[表241]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-0053 | H | H | H | H | H | 3-F-4-Cl-吡啶-2-基 | 0 |
D-0054 | H | H | H | H | H | 3-F-5-Cl-吡啶-2-基 | 0 |
D-0055 | H | H | H | H | H | 3-F-6-Cl-吡啶-2-基 | 0 |
D-0056 | H | H | H | H | H | 3-F-4-Me-吡啶-2-基 | 0 |
D-0057 | H | H | H | H | H | 3-F-5-Me-吡啶-2-基 | 0 |
D-0058 | H | H | H | H | H | 3-F-6-Me-吡啶-2-基 | 0 |
D-0059 | H | H | H | H | H | 3-F-4-OMe-吡啶-2-基 | 0 |
D-0060 | H | H | H | H | H | 3-F-5-OMe-吡啶-2-基 | 0 |
D-0061 | H | H | H | H | H | 3-F-6-OMe-吡啶-2-基 | 0 |
D-0062 | H | H | H | H | H | 3-Cl-4-F-吡啶-2-基 | 0 |
D-0063 | H | H | H | H | H | 3-Cl-5-F-吡啶-2-基 | 0 |
D-0064 | H | H | H | H | H | 3-Cl-6-F-吡啶-2-基 | 0 |
D-0065 | H | H | H | H | H | 3-Cl-4-Me-吡啶-2-基 | 0 |
D-0066 | H | H | H | H | H | 3-Cl-5-Me-吡啶-2-基 | 0 |
D-0067 | H | H | H | H | H | 3-Cl-6-Me-吡啶-2-基 | 0 |
D-0068 | H | H | H | H | H | 3-Me-4-F-吡啶-2-基 | 0 |
D-0069 | H | H | H | H | H | 3-Me-5-F-吡啶-2-基 | 0 |
D-0070 | H | H | H | H | H | 3-Me-6-F-吡啶-2-基 | 0 |
D-0071 | H | H | H | H | H | 3-Me-4-Cl-吡啶-2-基 | 0 |
D-0072 | H | H | H | H | H | 3-Me-5-Cl-吡啶-2-基 | 0 |
D-0073 | H | H | H | H | H | 3-Me-6-Cl-吡啶-2-基 | 0 |
D-0074 | H | H | H | H | H | 3,4-(Me)2-吡啶-2-基 | 0 |
D-0075 | H | H | H | H | H | 3,5-(Me)2-吡啶-2-基 | 0 |
D-0076 | H | H | H | H | H | 3,6-(Me)2-吡啶-2-基 | 0 |
D-0077 | H | H | H | H | H | 3-Me-4-OMe-吡啶-2-基 | 0 |
D-0078 | H | H | H | H | H | 3-Me-5-OMe-吡啶-2-基 | 0 |
D-0079 | H | H | H | H | H | 3-Me-6-OMe-吡啶-2-基 | 0 |
D-0080 | H | H | H | H | H | 3-CF3-4-F-吡啶-2-基 | 0 |
D-0081 | H | H | H | H | H | 3-CF3-5-F-吡啶-2-基 | 0 |
D-0082 | H | H | H | H | H | 3-CF3-6-F-吡啶-2-基 | 0 |
D-0083 | H | H | H | H | H | 3-CF3-4-Me-吡啶-2-基 | 0 |
D-0084 | H | H | H | H | H | 3-CF3-5-Me-吡啶-2-基 | 0 |
D-0085 | H | H | H | H | H | 3-CF3-6-Me-吡啶-2-基 | 0 |
D-0086 | H | H | H | H | H | 3-OMe-4-F-吡啶-2-基 | 0 |
D-0087 | H | H | H | H | H | 3-OMe-5-F-吡啶-2-基 | 0 |
D-0088 | H | H | H | H | H | 3-OMe-6-F-吡啶-2-基 | 0 |
D-0089 | H | H | H | H | H | 3-OMe-4-Cl-吡啶-2-基 | 0 |
D-0090 | H | H | H | H | H | 3-OMe-5-Cl-吡啶-2-基 | 0 |
D-0091 | H | H | H | H | H | 3-OMe-6-Cl-吡啶-2-基 | 0 |
D-0092 | H | H | H | H | H | 3-OMe-4-Me-吡啶-2-基 | 0 |
D-0093 | H | H | H | H | H | 3-OMe-5-Me-吡啶-2-基 | 0 |
D-0094 | H | H | H | H | H | 3-OMe-6-Me-吡啶-2-基 | 0 |
D-0095 | H | H | H | H | H | 3,4-(OMe)2-吡啶-2-基 | 0 |
D-0096 | H | H | H | H | H | 3,5-(OMe)2-吡啶-2-基 | 0 |
D-0097 | H | H | H | H | H | 3,6-(OMe)2-吡啶-2-基 | 0 |
D-0098 | H | H | H | H | H | 吡啶-3-基 | 0 |
D-0099 | H | H | H | H | H | 2-F-吡啶-3-基 | 0 |
D-0100 | H | H | H | H | H | 4-F-吡啶-3-基 | 0 |
D-0101 | H | H | H | H | H | 5-F-吡啶-3-基 | 0 |
D-0102 | H | H | H | H | H | 6-F-吡啶-3-基 | 0 |
D-0103 | H | H | H | H | H | 2-Cl-吡啶-3-基 | 0 |
D-0104 | H | H | H | H | H | 4-Cl-吡啶-3-基 | 0 |
D-0105 | H | H | H | H | H | 5-Cl-吡啶-3-基 | 0 |
D-0106 | H | H | H | H | H | 6-Cl-吡啶-3-基 | 0 |
D-0107 | H | H | H | H | H | 2-Me-吡啶-3-基 | 0 |
D-0108 | H | H | H | H | H | 4-Me-吡啶-3-基 | 0 |
D-0109 | H | H | H | H | H | 5-Me-吡啶-3-基 | 0 |
[表242]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-0110 | H | H | H | H | H | 6-Me-吡啶-3-基 | 0 |
D-0111 | H | H | H | H | H | 2-CF3-吡啶-3-基 | 0 |
D-0112 | H | H | H | H | H | 4-CF3-吡啶-3-基 | 0 |
D-0113 | H | H | H | H | H | 5-CF3-吡啶-3-基 | 0 |
D-0114 | H | H | H | H | H | 6-CF3-吡啶-3-基 | 0 |
D-0115 | H | H | H | H | H | 2-OMe-吡啶-3-基 | 0 |
D-0116 | H | H | H | H | H | 4-OMe-吡啶-3-基 | 0 |
D-0117 | H | H | H | H | H | 5-OMe-吡啶-3-基 | 0 |
D-0118 | H | H | H | H | H | 6-OMe-吡啶-3-基 | 0 |
D-0119 | H | H | H | H | H | 2,4-F2-吡啶-3-基 | 0 |
D-0120 | H | H | H | H | H | 2,5-F2-吡啶-3-基 | 0 |
D-0121 | H | H | H | H | H | 2,6-F2-吡啶-3-基 | 0 |
D-0122 | H | H | H | H | H | 4,5-F2-吡啶-3-基 | 0 |
D-0123 | H | H | H | H | H | 4,6-F2-吡啶-3-基 | 0 |
D-0124 | H | H | H | H | H | 2,4-Cl2-吡啶-3-基 | 0 |
D-0125 | H | H | H | H | H | 2,5-Cl2-吡啶-3-基 | 0 |
D-0126 | H | H | H | H | H | 2,6-Cl2-吡啶-3-基 | 0 |
D-0127 | H | H | H | H | H | 4,5-Cl2-吡啶-3-基 | 0 |
D-0128 | H | H | H | H | H | 4,6-Cl2-吡啶-3-基 | 0 |
D-0129 | H | H | H | H | H | 2-F-4-Cl-吡啶-3-基 | 0 |
D-0130 | H | H | H | H | H | 2-F-5-Cl-吡啶-3-基 | 0 |
D-0131 | H | H | H | H | H | 2-F-6-Cl-吡啶-3-基 | 0 |
D-0132 | H | H | H | H | H | 4-F-2-Cl-吡啶-3-基 | 0 |
D-0133 | H | H | H | H | H | 4-F-5-Cl-吡啶-3-基 | 0 |
D-0134 | H | H | H | H | H | 4-F-6-Cl-吡啶-3-基 | 0 |
D-0135 | H | H | H | H | H | 2-F-4-Me-吡啶-3-基 | 0 |
D-0136 | H | H | H | H | H | 2-F-5-Me-吡啶-3-基 | 0 |
D-0137 | H | H | H | H | H | 2-F-6-Me-吡啶-3-基 | 0 |
D-0138 | H | H | H | H | H | 4-F-2-Me-吡啶-3-基 | 0 |
D-0139 | H | H | H | H | H | 4-F-5-Me-吡啶-3-基 | 0 |
D-0140 | H | H | H | H | H | 4-F-6-Me-吡啶-3-基 | 0 |
D-0141 | H | H | H | H | H | 2-F-4-OMe-吡啶-3-基 | 0 |
D-0142 | H | H | H | H | H | 2-F-5-OMe-吡啶-3-基 | 0 |
D-0143 | H | H | H | H | H | 2-F-6-OMe-吡啶-3-基 | 0 |
D-0144 | H | H | H | H | H | 4-F-2-OMe-吡啶-3-基 | 0 |
D-0145 | H | H | H | H | H | 4-F-5-OMe-吡啶-3-基 | 0 |
D-0146 | H | H | H | H | H | 4-F-6-OMe-吡啶-3-基 | 0 |
D-0147 | H | H | H | H | H | 2-Cl-5-F-吡啶-3-基 | 0 |
D-0148 | H | H | H | H | H | 2-Cl-6-F-吡啶-3-基 | 0 |
D-0149 | H | H | H | H | H | 4-Cl-5-F-吡啶-3-基 | 0 |
D-0150 | H | H | H | H | H | 4-Cl-6-F-吡啶-3-基 | 0 |
D-0151 | H | H | H | H | H | 2-Cl-4-Me-吡啶-3-基 | 0 |
D-0152 | H | H | H | H | H | 2-Cl-5-Me-吡啶-3-基 | 0 |
D-0153 | H | H | H | H | H | 2-Cl-6-Me-吡啶-3-基 | 0 |
D-0154 | H | H | H | H | H | 4-Cl-2-Me-吡啶-3-基 | 0 |
D-0155 | H | H | H | H | H | 4-Cl-5-Me-吡啶-3-基 | 0 |
D-0156 | H | H | H | H | H | 4-Cl-6-Me-吡啶-3-基 | 0 |
D-0157 | H | H | H | H | H | 2-Me-5-F-吡啶-3-基 | 0 |
D-0158 | H | H | H | H | H | 2-Me-6-F-吡啶-3-基 | 0 |
D-0159 | H | H | H | H | H | 4-Me-5-F-吡啶-3-基 | 0 |
D-0160 | H | H | H | H | H | 4-Me-6-F-吡啶-3-基 | 0 |
D-0161 | H | H | H | H | H | 2-Me-5-Cl-吡啶-3-基 | 0 |
D-0162 | H | H | H | H | H | 2-Me-6-Cl-吡啶-3-基 | 0 |
D-0163 | H | H | H | H | H | 4-Me-5-Cl-吡啶-3-基 | 0 |
D-0164 | H | H | H | H | H | 4-Me-6-Cl-吡啶-3-基 | 0 |
D-0165 | H | H | H | H | H | 2,4-(Me)2-吡啶-3-基 | 0 |
D-0166 | H | H | H | H | H | 2,5-(Me)2-吡啶-3-基 | 0 |
[表243]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-0167 | H | H | H | H | H | 2,6-(Me)2-吡啶-3-基 | 0 |
D-0168 | H | H | H | H | H | 4,5-(Me)2-吡啶-3-基 | 0 |
D-0169 | H | H | H | H | H | 4,6-(Me)2-吡啶-3-基 | 0 |
D-0170 | H | H | H | H | H | 2-Me-4-OMe-吡啶-3-基 | 0 |
D-0171 | H | H | H | H | H | 2-Me-5-OMe-吡啶-3-基 | 0 |
D-0172 | H | H | H | H | H | 2-Me-6-OMe-吡啶-3-基 | 0 |
D-0173 | H | H | H | H | H | 4-Me-2-OMe-吡啶-3-基 | 0 |
D-0174 | H | H | H | H | H | 4-Me-5-OMe-吡啶-3-基 | 0 |
D-0175 | H | H | H | H | H | 4-Me-6-OMe-吡啶-3-基 | 0 |
D-0176 | H | H | H | H | H | 2-CF3-4-F-吡啶-3-基 | 0 |
D-0177 | H | H | H | H | H | 2-CF3-5-F-吡啶-3-基 | 0 |
D-0178 | H | H | H | H | H | 2-CF3-6-F-吡啶-3-基 | 0 |
D-0179 | H | H | H | H | H | 4-CF3-2-F-吡啶-3-基 | 0 |
D-0180 | H | H | H | H | H | 4-CF3-5-F-吡啶-3-基 | 0 |
D-0181 | H | H | H | H | H | 4-CF3-6-F-吡啶-3-基 | 0 |
D-0182 | H | H | H | H | H | 2-CF3-4-Me-吡啶-3-基 | 0 |
D-0183 | H | H | H | H | H | 2-CF3-5-Me-吡啶-3-基 | 0 |
D-0184 | H | H | H | H | H | 2-CF3-6-Me-吡啶-3-基 | 0 |
D-0185 | H | H | H | H | H | 4-CF3-2-Me-吡啶-3-基 | 0 |
D-0186 | H | H | H | H | H | 4-CF3-5-Me-吡啶-3-基 | 0 |
D-0187 | H | H | H | H | H | 4-CF3-6-Me-吡啶-3-基 | 0 |
D-0188 | H | H | H | H | H | 2-OMe-5-F-吡啶-3-基 | 0 |
D-0189 | H | H | H | H | H | 2-OMe-6-F-吡啶-3-基 | 0 |
D-0190 | H | H | H | H | H | 4-OMe-5-F-吡啶-3-基 | 0 |
D-0191 | H | H | H | H | H | 4-OMe-6-F-吡啶-3-基 | 0 |
D-0192 | H | H | H | H | H | 2-OMe-4-Cl-吡啶-3-基 | 0 |
D-0193 | H | H | H | H | H | 2-OMe-5-Cl-吡啶-3-基 | 0 |
D-0194 | H | H | H | H | H | 2-OMe-6-Cl-吡啶-3-基 | 0 |
D-0195 | H | H | H | H | H | 4-OMe-2-Cl-吡啶-3-基 | 0 |
D-0196 | H | H | H | H | H | 4-OMe-5-Cl-吡啶-3-基 | 0 |
D-0197 | H | H | H | H | H | 4-OMe-6-Cl-吡啶-3-基 | 0 |
D-0198 | H | H | H | H | H | 2-OMe-5-Me-吡啶-3-基 | 0 |
D-0199 | H | H | H | H | H | 2-OMe-6-Me-吡啶-3-基 | 0 |
D-0200 | H | H | H | H | H | 4-OMe-5-Me-吡啶-3-基 | 0 |
D-0201 | H | H | H | H | H | 4-OMe-6-Me-吡啶-3-基 | 0 |
D-0202 | H | H | H | H | H | 2,4-(OMe)2-吡啶-3-基 | 0 |
D-0203 | H | H | H | H | H | 2,5-(OMe)2-吡啶-3-基 | 0 |
D-0204 | H | H | H | H | H | 2,6-(OMe)2-吡啶-3-基 | 0 |
D-0205 | H | H | H | H | H | 4,5-(OMe)2-吡啶-3-基 | 0 |
D-0206 | H | H | H | H | H | 4,6-(OMe)2-吡啶-3-基 | 0 |
D-0207 | H | H | H | H | H | 吡啶-4-基 | 0 |
D-0208 | H | H | H | H | H | 2-F-吡啶-4-基 | 0 |
D-0209 | H | H | H | H | H | 3-F-吡啶-4-基 | 0 |
D-0210 | H | H | H | H | H | 2-Cl-吡啶-4-基 | 0 |
D-0211 | H | H | H | H | H | 3-Cl-吡啶-4-基 | 0 |
D-0212 | H | H | H | H | H | 2-Me-吡啶-4-基 | 0 |
D-0213 | H | H | H | H | H | 3-Me-吡啶-4-基 | 0 |
D-0214 | H | H | H | H | H | 2-CF3-吡啶-4-基 | 0 |
D-0215 | H | H | H | H | H | 3-CF3-吡啶-4-基 | 0 |
D-0216 | H | H | H | H | H | 2-OMe-吡啶-4-基 | 0 |
D-0217 | H | H | H | H | H | 3-OMe-吡啶-4-基 | 0 |
D-0218 | H | H | H | H | H | 2,3-F2-吡啶-4-基 | 0 |
D-0219 | H | H | H | H | H | 2,5-F2-吡啶-4-基 | 0 |
D-0220 | H | H | H | H | H | 2,6-F2-吡啶-4-基 | 0 |
D-0221 | H | H | H | H | H | 3,5-F2-吡啶-4-基 | 0 |
D-0222 | H | H | H | H | H | 2,3-Cl2-吡啶-4-基 | 0 |
D-0223 | H | H | H | H | H | 2,5-Cl2-吡啶-4-基 | 0 |
[表244]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-0224 | H | H | H | H | H | 2,6-Cl2-吡啶-4-基 | 0 |
D-0225 | H | H | H | H | H | 3,5-Cl2-吡啶-4-基 | 0 |
D-0226 | H | H | H | H | H | 3-F-2-Cl-吡啶-4-基 | 0 |
D-0227 | H | H | H | H | H | 3-F-5-Cl-吡啶-4-基 | 0 |
D-0228 | H | H | H | H | H | 3-F-6-Cl-吡啶-4-基 | 0 |
D-0229 | H | H | H | H | H | 3-F-2-Me-吡啶-4-基 | 0 |
D-0230 | H | H | H | H | H | 3-F-5-Me-吡啶-4-基 | 0 |
D-0231 | H | H | H | H | H | 3-F-6-Me-吡啶-4-基 | 0 |
D-0232 | H | H | H | H | H | 3-F-2-OMe-吡啶-4-基 | 0 |
D-0233 | H | H | H | H | H | 3-F-5-OMe-吡啶-4-基 | 0 |
D-0234 | H | H | H | H | H | 3-F-6-OMe-吡啶-4-基 | 0 |
D-0235 | H | H | H | H | H | 3-Cl-2-F-吡啶-4-基 | 0 |
D-0236 | H | H | H | H | H | 3-Cl-6-F-吡啶-4-基 | 0 |
D-0237 | H | H | H | H | H | 3-Cl-2-Me-吡啶-4-基 | 0 |
D-0238 | H | H | H | H | H | 3-Cl-5-Me-吡啶-4-基 | 0 |
D-0239 | H | H | H | H | H | 3-Cl-6-Me-吡啶-4-基 | 0 |
D-0240 | H | H | H | H | H | 3-Me-2-F-吡啶-4-基 | 0 |
D-0241 | H | H | H | H | H | 3-Me-6-F-吡啶-4-基 | 0 |
D-0242 | H | H | H | H | H | 3-Me-2-Cl-吡啶-4-基 | 0 |
D-0243 | H | H | H | H | H | 3-Me-6-Cl-吡啶-4-基 | 0 |
D-0244 | H | H | H | H | H | 2,3-(Me)2-吡啶-4-基 | 0 |
D-0245 | H | H | H | H | H | 3,5-(Me)2-吡啶-4-基 | 0 |
D-0246 | H | H | H | H | H | 3,6-(Me)2-吡啶-4-基 | 0 |
D-0247 | H | H | H | H | H | 3-Me-2-OMe-吡啶-4-基 | 0 |
D-0248 | H | H | H | H | H | 3-Me-5-OMe-吡啶-4-基 | 0 |
D-0249 | H | H | H | H | H | 3-Me-6-OMe-吡啶-4-基 | 0 |
D-0250 | H | H | H | H | H | 3-CF3-2-F-吡啶-4-基 | 0 |
D-0251 | H | H | H | H | H | 3-CF3-5-F-吡啶-4-基 | 0 |
D-0252 | H | H | H | H | H | 3-CF3-6-F-吡啶-4-基 | 0 |
D-0253 | H | H | H | H | H | 3-CF3-2-Me-吡啶-4-基 | 0 |
D-0254 | H | H | H | H | H | 3-CF3-5-Me-吡啶-4-基 | 0 |
D-0255 | H | H | H | H | H | 3-CF3-6-Me-吡啶-4-基 | 0 |
D-0256 | H | H | H | H | H | 3-OMe-2-F-吡啶-4-基 | 0 |
D-0257 | H | H | H | H | H | 3-OMe-6-F-吡啶-4-基 | 0 |
D-0258 | H | H | H | H | H | 3-OMe-2-Cl-吡啶-4-基 | 0 |
D-0259 | H | H | H | H | H | 3-OMe-5-Cl-吡啶-4-基 | 0 |
D-0260 | H | H | H | H | H | 3-OMe-6-Cl-吡啶-4-基 | 0 |
D-0261 | H | H | H | H | H | 3-OMe-2-Me-吡啶-4-基 | 0 |
D-0262 | H | H | H | H | H | 3-OMe-6-Me-吡啶-4-基 | 0 |
D-0263 | H | H | H | H | H | 2,3-(OMe)2-吡啶-4-基 | 0 |
D-0264 | H | H | H | H | H | 3,5-(OMe)2-吡啶-4-基 | 0 |
D-0265 | H | H | H | H | H | 3,6-(OMe)2-吡啶-4-基 | 0 |
D-0266 | H | H | H | H | H | 嘧啶-2-基 | 0 |
D-0267 | H | H | H | H | H | 嘧啶-4-基 | 0 |
D-0268 | H | H | H | H | H | 5-F-嘧啶-4-基 | 0 |
D-0269 | H | H | H | H | H | 5-Me-嘧啶-4-基 | 0 |
D-0270 | H | H | H | H | H | 5-CF3-嘧啶-4-基 | 0 |
D-0271 | H | H | H | H | H | 5-OMe-嘧啶-4-基 | 0 |
D-0272 | H | H | H | H | H | 嘧啶-5-基 | 0 |
D-0273 | H | H | H | H | H | 4-F-嘧啶-5-基 | 0 |
D-0274 | H | H | H | H | H | 4-Cl-嘧啶-5-基 | 0 |
D-0275 | H | H | H | H | H | 4-Me-嘧啶-5-基 | 0 |
D-0276 | H | H | H | H | H | 4-CF3-嘧啶-5-基 | 0 |
D-0277 | H | H | H | H | H | 4-OMe-嘧啶-5-基 | 0 |
D-0278 | H | H | H | H | H | 哒嗪-3-基 | 0 |
D-0279 | H | H | H | H | H | 4-F-哒嗪-3-基 | 0 |
D-0280 | H | H | H | H | H | 4-Cl-哒嗪-3-基 | 0 |
[表245]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-0281 | H | H | H | H | H | 4-Me-哒嗪-3-基 | 0 |
D-0282 | H | H | H | H | H | 4-CF<sub>3</sub>-哒嗪-3-基 | 0 |
D-0283 | H | H | H | H | H | 4-OMe-哒嗪-3-基 | 0 |
D-0284 | H | H | H | H | H | 哒嗪-4-基 | 0 |
D-0285 | H | H | H | H | H | 3-F-哒嗪-4-基 | 0 |
D-0286 | H | H | H | H | H | 3-Cl-哒嗪-4-基 | 0 |
D-0287 | H | H | H | H | H | 3-Me-哒嗪-4-基 | 0 |
D-0288 | H | H | H | H | H | 3-CF<sub>3</sub>-哒嗪-4-基 | 0 |
D-0289 | H | H | H | H | H | 3-OMe-哒嗪-4-基 | 0 |
D-0290 | H | H | H | H | H | 5-F-哒嗪-4-基 | 0 |
D-0291 | H | H | H | H | H | 5-Cl-哒嗪-4-基 | 0 |
D-0292 | H | H | H | H | H | 5-Me-哒嗪-4-基 | 0 |
D-0293 | H | H | H | H | H | 5-CF3-哒嗪-4-基 | 0 |
D-0294 | H | H | H | H | H | 5-OMe-哒嗪-4-基 | 0 |
D-0295 | H | H | H | H | H | 噻吩-2-基 | 0 |
D-0296 | H | H | H | H | H | 3-F-噻吩-2-基 | 0 |
D-0297 | H | H | H | H | H | 3-Cl-噻吩-2-基 | 0 |
D-0298 | H | H | H | H | H | 3-Me-噻吩-2-基 | 0 |
D-0299 | H | H | H | H | H | 3-CF<sub>3</sub>-噻吩-2-基 | 0 |
D-0300 | H | H | H | H | H | 3-OMe-噻吩-2-基 | 0 |
D-0301 | H | H | H | H | H | 噻吩-3-基 | 0 |
D-0302 | H | H | H | H | H | 2-F-噻吩-3-基 | 0 |
D-0303 | H | H | H | H | H | 2-Cl-噻吩-3-基 | 0 |
D-0304 | H | H | H | H | H | 2-Me-噻吩-3-基 | 0 |
D-0305 | H | H | H | H | H | 2-CF<sub>3</sub>-噻吩-3-基 | 0 |
D-0306 | H | H | H | H | H | 2-OMe-噻吩-3-基 | 0 |
D-0307 | H | H | H | H | H | 4-F-噻吩-3-基 | 0 |
D-0308 | H | H | H | H | H | 4-Cl-噻吩-3-基 | 0 |
D-0309 | H | H | H | H | H | 4-Me-噻吩-3-基 | 0 |
D-0310 | H | H | H | H | H | 4-CF3-噻吩-3-基 | 0 |
D-0311 | H | H | H | H | H | 4-OMe-噻吩-3-基 | 0 |
D-0312 | H | H | H | H | H | 噻唑-2-基 | 0 |
D-0313 | H | H | H | H | H | 噻唑-4-基 | 0 |
D-0314 | H | H | H | H | H | 5-F-噻唑-4-基 | 0 |
D-0315 | H | H | H | H | H | 5-Me-噻唑-4-基 | 0 |
D-0316 | H | H | H | H | H | 5-CF<sub>3</sub>-噻唑-4-基 | 0 |
D-0317 | H | H | H | H | H | 5-OMe-噻唑-4-基 | 0 |
D-0318 | H | H | H | H | H | 噻唑-5-基 | 0 |
D-0319 | H | H | H | H | H | 4-F-噻唑-5-基 | 0 |
D-0320 | H | H | H | H | H | 4-Me-噻唑-5-基 | 0 |
D-0321 | H | H | H | H | H | 4-CF<sub>3</sub>-噻唑-5-基 | 0 |
D-0322 | H | H | H | H | H | 4-OMe-噻唑-5-基 | 0 |
D-0323 | H | H | H | H | H | 1H-吡咯-1-基 | 0 |
D-0324 | H | H | H | H | H | 2-F-1H-吡咯-1-基 | 0 |
D-0325 | H | H | H | H | H | 2-Me-1H-吡咯-1-基 | 0 |
D-0326 | H | H | H | H | H | 2-CF<sub>3</sub>-1H-吡咯-1-基 | 0 |
D-0327 | H | H | H | H | H | 2-OMe-1H-吡咯-1-基 | 0 |
D-0328 | H | H | H | H | H | 1H-吡咯-2-基 | 0 |
D-0329 | H | H | H | H | H | 1-Me-1H-吡咯-2-基 | 0 |
D-0330 | H | H | H | H | H | 3-F-1H-吡咯-2-基 | 0 |
D-0331 | H | H | H | H | H | 3-Me-1H-吡咯-2-基 | 0 |
D-0332 | H | H | H | H | H | 3-CF<sub>3</sub>-1H-吡咯-2-基 | 0 |
D-0333 | H | H | H | H | H | 3-OMe-1H-吡咯-2-基 | 0 |
D-0334 | H | H | H | H | H | 1-Me-3-F-1H-吡咯-2-基 | 0 |
D-0335 | H | H | H | H | H | 1,3-(Me)<sub>2</sub>-1H-吡咯-2-基 | 0 |
D-0336 | H | H | H | H | H | 1-Me-3-CF3-1H-吡咯-2-基 | 0 |
D-0337 | H | H | H | H | H | 1-Me-3-OMe-1H-吡咯-2-基 | 0 |
[表246]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-0338 | H | H | H | H | H | 1H-吡咯-3-基 | 0 |
D-0339 | H | H | H | H | H | 1-Me-1H-吡咯-3-基 | 0 |
D-0340 | H | H | H | H | H | 2-F-1H-吡咯-3-基 | 0 |
D-0341 | H | H | H | H | H | 2-Me-1H-吡咯-3-基 | 0 |
D-0342 | H | H | H | H | H | 2-CF<sub>3</sub>-1H-吡咯-3-基 | 0 |
D-0343 | H | H | H | H | H | 2-OMe-1H-吡咯-3-基 | 0 |
D-0344 | H | H | H | H | H | 1-Me-2-F-1H-吡咯-3-基 | 0 |
D-0345 | H | H | H | H | H | 1,2-(Me)<sub>2</sub>-1H-吡咯-3-基 | 0 |
D-0346 | H | H | H | H | H | 1-Me-2-CF<sub>3</sub>-1H-吡咯-3-基 | 0 |
D-0347 | H | H | H | H | H | 1-Me-2-OMe-1H-吡咯-3-基 | 0 |
D-0348 | H | H | H | H | H | 4-F-1H-吡咯-3-基 | 0 |
D-0349 | H | H | H | H | H | 4-Me-1H-吡咯-3-基 | 0 |
D-0350 | H | H | H | H | H | 4-CF<sub>3</sub>-1H-吡咯-3-基 | 0 |
D-0351 | H | H | H | H | H | 4-OMe-1H-吡咯-3-基 | 0 |
D-0352 | H | H | H | H | H | 1-Me-4-F-1H-吡咯-3-基 | 0 |
D-0353 | H | H | H | H | H | 1,4-(Me)2-1H-吡咯-3-基 | 0 |
D-0354 | H | H | H | H | H | 1-Me-4-CF<sub>3</sub>-1H-吡咯-3-基 | 0 |
D-0355 | H | H | H | H | H | 1-Me-4-OMe-1H-吡咯-3-基 | 0 |
D-0356 | H | H | H | H | H | 1H-吡唑-1-基 | 0 |
D-0357 | H | H | H | H | H | 5-F-1H-吡唑-1-基 | 0 |
D-0358 | H | H | H | H | H | 5-Cl-1H-吡唑-1-基 | 0 |
D-0359 | H | H | H | H | H | 5-Me-1H-吡唑-1-基 | 0 |
D-0360 | H | H | H | H | H | 5-CF<sub>3</sub>-1H-吡唑-1-基 | 0 |
D-0361 | H | H | H | H | H | 5-OMe-1H-吡唑-1-基 | 0 |
D-0362 | H | H | H | H | H | 1H-吡唑-3-基 | 0 |
D-0363 | H | H | H | H | H | 1-Me-1H-吡唑-3-基 | 0 |
D-0364 | H | H | H | H | H | 4-F-1H-吡唑-3-基 | 0 |
D-0365 | H | H | H | H | H | 4-Cl-1H-吡唑-3-基 | 0 |
D-0366 | H | H | H | H | H | 4-Me-1H-吡唑-3-基 | 0 |
D-0367 | H | H | H | H | H | 4-CF<sub>3</sub>-1H-吡唑-3-基 | 0 |
D-0368 | H | H | H | H | H | 4-OMe-1H-吡唑-3-基 | 0 |
D-0369 | H | H | H | H | H | 1-Me-4-F-1H-吡唑-3-基 | 0 |
D-0370 | H | H | H | H | H | 1-Me-4-Cl-1H-吡唑-3-基 | 0 |
D-0371 | H | H | H | H | H | 1,4-(Me)<sub>2</sub>-1H-吡唑-3-基 | 0 |
D-0372 | H | H | H | H | H | 1-Me-4-CF<sub>3</sub>-1H-吡唑-3-基 | 0 |
D-0373 | H | H | H | H | H | 1-Me-4-OMe-1H-吡唑-3-基 | 0 |
D-0374 | H | H | H | H | H | 1H-吡唑-4-基 | 0 |
D-0375 | H | H | H | H | H | 1-Me-1H-吡唑-4-基 | 0 |
D-0376 | H | H | H | H | H | 3-F-1H-吡唑-4-基 | 0 |
D-0377 | H | H | H | H | H | 3-Cl-1H-吡唑-4-基 | 0 |
D-0378 | H | H | H | H | H | 3-Me-1H-吡唑-4-基 | 0 |
D-0379 | H | H | H | H | H | 3-CF<sub>3</sub>-1H-吡唑-4-基 | 0 |
D-0380 | H | H | H | H | H | 3-OMe-1H-吡唑-4-基 | 0 |
D-0381 | H | H | H | H | H | 1-Me-3-F-1H-吡唑-4-基 | 0 |
D-0382 | H | H | H | H | H | 1-Me-3-Cl-1H-吡唑-4-基 | 0 |
D-0383 | H | H | H | H | H | 1,3-(Me)<sub>2</sub>-1H-吡唑-4-基 | 0 |
D-0384 | H | H | H | H | H | 1-Me-3-CF<sub>3</sub>-1H-吡唑-4-基 | 0 |
D-0385 | H | H | H | H | H | 1-Me-3-OMe-1H-吡唑-4-基 | 0 |
D-0386 | H | H | H | H | H | 5-F-1H-吡唑-4-基 | 0 |
D-0387 | H | H | H | H | H | 5-Cl-1H-吡唑-4-基 | 0 |
D-0388 | H | H | H | H | H | 5-Me-1H-吡唑-4-基 | 0 |
D-0389 | H | H | H | H | H | 5-CF<sub>3</sub>-1H-吡唑-4-基 | 0 |
D-0390 | H | H | H | H | H | 5-OMe-1H-吡唑-4-基 | 0 |
D-0391 | H | H | H | H | H | 1-Me-5-F-1H-吡唑-4-基 | 0 |
D-0392 | H | H | H | H | H | 1-Me-5-Cl-1H-吡唑-4-基 | 0 |
D-0393 | H | H | H | H | H | 1,5-(Me)<sub>2</sub>-1H-吡唑-4-基 | 0 |
D-0394 | H | H | H | H | H | 1-Me-5-CF3-1H-吡唑-4-基 | 0 |
[表247]
[表248]
[表249]
[表250]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-5053 | H | H | H | H | H | 3-F-4-Cl-吡啶-2-基 | 1 |
D-5054 | H | H | H | H | H | 3-F-5-Cl-吡啶-2-基 | 1 |
D-5055 | H | H | H | H | H | 3-F-6-Cl-吡啶-2-基 | 1 |
D-5056 | H | H | H | H | H | 3-F-4-Me-吡啶-2-基 | 1 |
D-5057 | H | H | H | H | H | 3-F-5-Me-吡啶-2-基 | 1 |
D-5058 | H | H | H | H | H | 3-F-6-Me-吡啶-2-基 | 1 |
D-5059 | H | H | H | H | H | 3-F-4-OMe-吡啶-2-基 | 1 |
D-5060 | H | H | H | H | H | 3-F-5-OMe-吡啶-2-基 | 1 |
D-5061 | H | H | H | H | H | 3-F-6-OMe-吡啶-2-基 | 1 |
D-5062 | H | H | H | H | H | 3-Cl-4-F-吡啶-2-基 | 1 |
D-5063 | H | H | H | H | H | 3-Cl-5-F-吡啶-2-基 | 1 |
D-5064 | H | H | H | H | H | 3-Cl-6-F-吡啶-2-基 | 1 |
D-5065 | H | H | H | H | H | 3-Cl-4-Me-吡啶-2-基 | 1 |
D-5066 | H | H | H | H | H | 3-Cl-5-Me-吡啶-2-基 | 1 |
D-5067 | H | H | H | H | H | 3-Cl-6-Me-吡啶-2-基 | 1 |
D-5068 | H | H | H | H | H | 3-Me-4-F-吡啶-2-基 | 1 |
D-5069 | H | H | H | H | H | 3-Me-5-F-吡啶-2-基 | 1 |
D-5070 | H | H | H | H | H | 3-Me-6-F-吡啶-2-基 | 1 |
D-5071 | H | H | H | H | H | 3-Me-4-Cl-吡啶-2-基 | 1 |
D-5072 | H | H | H | H | H | 3-Me-5-Cl-吡啶-2-基 | 1 |
D-5073 | H | H | H | H | H | 3-Me-6-Cl-吡啶-2-基 | 1 |
D-5074 | H | H | H | H | H | 3,4-(Me)2-吡啶-2-基 | 1 |
D-5075 | H | H | H | H | H | 3,5-(Me)2-吡啶-2-基 | 1 |
D-5076 | H | H | H | H | H | 3,6-(Me)2-吡啶-2-基 | 1 |
D-5077 | H | H | H | H | H | 3-Me-4-OMe-吡啶-2-基 | 1 |
D-5078 | H | H | H | H | H | 3-Me-5-OMe-吡啶-2-基 | 1 |
D-5079 | H | H | H | H | H | 3-Me-6-OMe-吡啶-2-基 | 1 |
D-5080 | H | H | H | H | H | 3-CF3-4-F-吡啶-2-基 | 1 |
D-5081 | H | H | H | H | H | 3-CF3-5-F-吡啶-2-基 | 1 |
D-5082 | H | H | H | H | H | 3-CF3-6-F-吡啶-2-基 | 1 |
D-5083 | H | H | H | H | H | 3-CF3-4-Me-吡啶-2-基 | 1 |
D-5084 | H | H | H | H | H | 3-CF3-5-Me-吡啶-2-基 | 1 |
D-5085 | H | H | H | H | H | 3-CF3-6-Me-吡啶-2-基 | 1 |
D-5086 | H | H | H | H | H | 3-OMe-4-F-吡啶-2-基 | 1 |
D-5087 | H | H | H | H | H | 3-OMe-5-F-吡啶-2-基 | 1 |
D-5088 | H | H | H | H | H | 3-OMe-6-F-吡啶-2-基 | 1 |
D-5089 | H | H | H | H | H | 3-OMe-4-Cl-吡啶-2-基 | 1 |
D-5090 | H | H | H | H | H | 3-OMe-5-Cl-吡啶-2-基 | 1 |
D-5091 | H | H | H | H | H | 3-OMe-6-Cl-吡啶-2-基 | 1 |
D-5092 | H | H | H | H | H | 3-OMe-4-Me-吡啶-2-基 | 1 |
D-5093 | H | H | H | H | H | 3-OMe-5-Me-吡啶-2-基 | 1 |
D-5094 | H | H | H | H | H | 3-OMe-6-Me-吡啶-2-基 | 1 |
D-5095 | H | H | H | H | H | 3,4-(OMe)2-吡啶-2-基 | 1 |
D-5096 | H | H | H | H | H | 3,5-(OMe)2-吡啶-2-基 | 1 |
D-5097 | H | H | H | H | H | 3,6-(OMe)2-吡啶-2-基 | 1 |
D-5098 | H | H | H | H | H | 吡啶-3-基 | 1 |
D-5099 | H | H | H | H | H | 2-F-吡啶-3-基 | 1 |
D-5100 | H | H | H | H | H | 4-F-吡啶-3-基 | 1 |
D-5101 | H | H | H | H | H | 5-F-吡啶-3-基 | 1 |
D-5102 | H | H | H | H | H | 6-F-吡啶-3-基 | 1 |
D-5103 | H | H | H | H | H | 2-Cl-吡啶-3-基 | 1 |
D-5104 | H | H | H | H | H | 4-Cl-吡啶-3-基 | 1 |
D-5105 | H | H | H | H | H | 5-Cl-吡啶-3-基 | 1 |
D-5106 | H | H | H | H | H | 6-Cl-吡啶-3-基 | 1 |
D-5107 | H | H | H | H | H | 2-Me-吡啶-3-基 | 1 |
D-5108 | H | H | H | H | H | 4-Me-吡啶-3-基 | 1 |
D-5109 | H | H | H | H | H | 5-Me-吡啶-3-基 | 1 |
[表251]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-5110 | H | H | H | H | H | 6-Me-吡啶-3-基 | 1 |
D-5111 | H | H | H | H | H | 2-CF<sub>3</sub>-吡啶-3-基 | 1 |
D-5112 | H | H | H | H | H | 4-CF<sub>3</sub>-吡啶-3-基 | 1 |
D-5113 | H | H | H | H | H | 5-CF<sub>3</sub>-吡啶-3-基 | 1 |
D-5114 | H | H | H | H | H | 6-CF<sub>3</sub>-吡啶-3-基 | 1 |
D-5115 | H | H | H | H | H | 2-OMe-吡啶-3-基 | 1 |
D-5116 | H | H | H | H | H | 4-OMe-吡啶-3-基 | 1 |
D-5117 | H | H | H | H | H | 5-OMe-吡啶-3-基 | 1 |
D-5118 | H | H | H | H | H | 6-OMe-吡啶-3-基 | 1 |
D-5119 | H | H | H | H | H | 2,4-F<sub>2</sub>-吡啶-3-基 | 1 |
D-5120 | H | H | H | H | H | 2,5-F<sub>2</sub>-吡啶-3-基 | 1 |
D-5121 | H | H | H | H | H | 2,6-F<sub>2</sub>-吡啶-3-基 | 1 |
D-5122 | H | H | H | H | H | 4,5-F<sub>2</sub>-吡啶-3-基 | 1 |
D-5123 | H | H | H | H | H | 4,6-F<sub>2</sub>-吡啶-3-基 | 1 |
D-5124 | H | H | H | H | H | 2,4-Cl<sub>2</sub>-吡啶-3-基 | 1 |
D-5125 | H | H | H | H | H | 2,5-Cl<sub>2</sub>-吡啶-3-基 | 1 |
D-5126 | H | H | H | H | H | 2,6-Cl<sub>2</sub>-吡啶-3-基 | 1 |
D-5127 | H | H | H | H | H | 4,5-Cl<sub>2</sub>-吡啶-3-基 | 1 |
D-5128 | H | H | H | H | H | 4,6-Cl<sub>2</sub>-吡啶-3-基 | 1 |
D-5129 | H | H | H | H | H | 2-F-4-Cl-吡啶-3-基 | 1 |
D-5130 | H | H | H | H | H | 2-F-5-Cl-吡啶-3-基 | 1 |
D-5131 | H | H | H | H | H | 2-F-6-Cl-吡啶-3-基 | 1 |
D-5132 | H | H | H | H | H | 4-F-2-Cl-吡啶-3-基 | 1 |
D-5133 | H | H | H | H | H | 4-F-5-Cl-吡啶-3-基 | 1 |
D-5134 | H | H | H | H | H | 4-F-6-Cl-吡啶-3-基 | 1 |
D-5135 | H | H | H | H | H | 2-F-4-Me-吡啶-3-基 | 1 |
D-5136 | H | H | H | H | H | 2-F-5-Me-吡啶-3-基 | 1 |
D-5137 | H | H | H | H | H | 2-F-6-Me-吡啶-3-基 | 1 |
D-5138 | H | H | H | H | H | 4-F-2-Me-吡啶-3-基 | 1 |
D-5139 | H | H | H | H | H | 4-F-5-Me-吡啶-3-基 | 1 |
D-5140 | H | H | H | H | H | 4-F-6-Me-吡啶-3-基 | 1 |
D-5141 | H | H | H | H | H | 2-F-4-OMe-吡啶-3-基 | 1 |
D-5142 | H | H | H | H | H | 2-F-5-OMe-吡啶-3-基 | 1 |
D-5143 | H | H | H | H | H | 2-F-6-OMe-吡啶-3-基 | 1 |
D-5144 | H | H | H | H | H | 4-F-2-OMe-吡啶-3-基 | 1 |
D-5145 | H | H | H | H | H | 4-F-5-OMe-吡啶-3-基 | 1 |
D-5146 | H | H | H | H | H | 4-F-6-OMe-吡啶-3-基 | 1 |
D-5147 | H | H | H | H | H | 2-Cl-5-F-吡啶-3-基 | 1 |
D-5148 | H | H | H | H | H | 2-Cl-6-F-吡啶-3-基 | 1 |
D-5149 | H | H | H | H | H | 4-Cl-5-F-吡啶-3-基 | 1 |
D-5150 | H | H | H | H | H | 4-Cl-6-F-吡啶-3-基 | 1 |
D-5151 | H | H | H | H | H | 2-Cl-4-Me-吡啶-3-基 | 1 |
D-5152 | H | H | H | H | H | 2-Cl-5-Me-吡啶-3-基 | 1 |
D-5153 | H | H | H | H | H | 2-Cl-6-Me-吡啶-3-基 | 1 |
D-5154 | H | H | H | H | H | 4-Cl-2-Me-吡啶-3-基 | 1 |
D-5155 | H | H | H | H | H | 4-Cl-5-Me-吡啶-3-基 | 1 |
D-5156 | H | H | H | H | H | 4-Cl-6-Me-吡啶-3-基 | 1 |
D-5157 | H | H | H | H | H | 2-Me-5-F-吡啶-3-基 | 1 |
D-5158 | H | H | H | H | H | 2-Me-6-F-吡啶-3-基 | 1 |
D-5159 | H | H | H | H | H | 4-Me-5-F-吡啶-3-基 | 1 |
D-5160 | H | H | H | H | H | 4-Me-6-F-吡啶-3-基 | 1 |
D-5161 | H | H | H | H | H | 2-Me-5-Cl-吡啶-3-基 | 1 |
D-5162 | H | H | H | H | H | 2-Me-6-Cl-吡啶-3-基 | 1 |
D-5163 | H | H | H | H | H | 4-Me-5-Cl-吡啶-3-基 | 1 |
D-5164 | H | H | H | H | H | 4-Me-6-Cl-吡啶-3-基 | 1 |
D-5165 | H | H | H | H | H | 2,4-(Me)<sub>2</sub>-吡啶-3-基 | 1 |
D-5166 | H | H | H | H | H | 2,5-(Me)<sub>2</sub>-吡啶-3-基 | 1 |
[表252]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-5167 | H | H | H | H | H | 2,6-(Me)<sub>2</sub>-吡啶-3-基 | 1 |
D-5168 | H | H | H | H | H | 4,5-(Me)<sub>2</sub>-吡啶-3-基 | 1 |
D-5169 | H | H | H | H | H | 4,6-(Me)<sub>2</sub>-吡啶-3-基 | 1 |
D-5170 | H | H | H | H | H | 2-Me-4-OMe-吡啶-3-基 | 1 |
D-5171 | H | H | H | H | H | 2-Me-5-OMe-吡啶-3-基 | 1 |
D-5172 | H | H | H | H | H | 2-Me-6-OMe-吡啶-3-基 | 1 |
D-5173 | H | H | H | H | H | 4-Me-2-OMe-吡啶-3-基 | 1 |
D-5174 | H | H | H | H | H | 4-Me-5-OMe-吡啶-3-基 | 1 |
D-5175 | H | H | H | H | H | 4-Me-6-OMe-吡啶-3-基 | 1 |
D-5176 | H | H | H | H | H | 2-CF<sub>3</sub>-4-F-吡啶-3-基 | 1 |
D-5177 | H | H | H | H | H | 2-CF<sub>3</sub>-5-F-吡啶-3-基 | 1 |
D-5178 | H | H | H | H | H | 2-CF<sub>3</sub>-6-F-吡啶-3-基 | 1 |
D-5179 | H | H | H | H | H | 4-CF<sub>3</sub>-2-F-吡啶-3-基 | 1 |
D-5180 | H | H | H | H | H | 4-CF<sub>3</sub>-5-F-吡啶-3-基 | 1 |
D-5181 | H | H | H | H | H | 4-CF<sub>3</sub>-6-F-吡啶-3-基 | 1 |
D-5182 | H | H | H | H | H | 2-CF<sub>3</sub>-4-Me-吡啶-3-基 | 1 |
D-5183 | H | H | H | H | H | 2-CF<sub>3</sub>-5-Me-吡啶-3-基 | 1 |
D-5184 | H | H | H | H | H | 2-CF<sub>3</sub>-6-Me-吡啶-3-基 | 1 |
D-5185 | H | H | H | H | H | 4-CF<sub>3</sub>-2-Me-吡啶-3-基 | 1 |
D-5186 | H | H | H | H | H | 4-CF<sub>3</sub>-5-Me-吡啶-3-基 | 1 |
D-5187 | H | H | H | H | H | 4-CF<sub>3</sub>-6-Me-吡啶-3-基 | 1 |
D-5188 | H | H | H | H | H | 2-OMe-5-F-吡啶-3-基 | 1 |
D-5189 | H | H | H | H | H | 2-OMe-6-F-吡啶-3-基 | 1 |
D-5190 | H | H | H | H | H | 4-OMe-5-F-吡啶-3-基 | 1 |
D-5191 | H | H | H | H | H | 4-OMe-6-F-吡啶-3-基 | 1 |
D-5192 | H | H | H | H | H | 2-OMe-4-Cl-吡啶-3-基 | 1 |
D-5193 | H | H | H | H | H | 2-OMe-5-Cl-吡啶-3-基 | 1 |
D-5194 | H | H | H | H | H | 2-OMe-6-Cl-吡啶-3-基 | 1 |
D-5195 | H | H | H | H | H | 4-OMe-2-Cl-吡啶-3-基 | 1 |
D-5196 | H | H | H | H | H | 4-OMe-5-Cl-吡啶-3-基 | 1 |
D-5197 | H | H | H | H | H | 4-OMe-6-Cl-吡啶-3-基 | 1 |
D-5198 | H | H | H | H | H | 2-OMe-5-Me-吡啶-3-基 | 1 |
D-5199 | H | H | H | H | H | 2-OMe-6-Me-吡啶-3-基 | 1 |
D-5200 | H | H | H | H | H | 4-OMe-5-Me-吡啶-3-基 | 1 |
D-5201 | H | H | H | H | H | 4-OMe-6-Me-吡啶-3-基 | 1 |
D-5202 | H | H | H | H | H | 2,4-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
D-5203 | H | H | H | H | H | 2,5-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
D-5204 | H | H | H | H | H | 2,6-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
D-5205 | H | H | H | H | H | 4,5-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
D-5206 | H | H | H | H | H | 4,6-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
D-5207 | H | H | H | H | H | 吡啶-4-基 | 1 |
D-5208 | H | H | H | H | H | 2-F-吡啶-4-基 | 1 |
D-5209 | H | H | H | H | H | 3-F-吡啶-4-基 | 1 |
D-5210 | H | H | H | H | H | 2-Cl-吡啶-4-基 | 1 |
D-5211 | H | H | H | H | H | 3-Cl-吡啶-4-基 | 1 |
D-5212 | H | H | H | H | H | 2-Me-吡啶-4-基 | 1 |
D-5213 | H | H | H | H | H | 3-Me-吡啶-4-基 | 1 |
D-5214 | H | H | H | H | H | 2-CF<sub>3</sub>-吡啶-4-基 | 1 |
D-5215 | H | H | H | H | H | 3-CF<sub>3</sub>-吡啶-4-基 | 1 |
D-5216 | H | H | H | H | H | 2-OMe-吡啶-4-基 | 1 |
D-5217 | H | H | H | H | H | 3-OMe-吡啶-4-基 | 1 |
D-5218 | H | H | H | H | H | 2,3-F<sub>2</sub>-吡啶-4-基 | 1 |
D-5219 | H | H | H | H | H | 2,5-F<sub>2</sub>-吡啶-4-基 | 1 |
D-5220 | H | H | H | H | H | 2,6-F<sub>2</sub>-吡啶-4-基 | 1 |
D-5221 | H | H | H | H | H | 3,5-F<sub>2</sub>-吡啶-4-基 | 1 |
D-5222 | H | H | H | H | H | 2,3-Cl<sub>2</sub>-吡啶-4-基 | 1 |
D-5223 | H | H | H | H | H | 2,5-Cl<sub>2</sub>-吡啶-4-基 | 1 |
[表253]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-5224 | H | H | H | H | H | 2,6-Cl<sub>2</sub>-吡啶-4-基 | 1 |
D-5225 | H | H | H | H | H | 3,5-Cl<sub>2</sub>-吡啶-4-基 | 1 |
D-5226 | H | H | H | H | H | 3-F-2-Cl-吡啶-4-基 | 1 |
D-5227 | H | H | H | H | H | 3-F-5-Cl-吡啶-4-基 | 1 |
D-5228 | H | H | H | H | H | 3-F-6-Cl-吡啶-4-基 | 1 |
D-5229 | H | H | H | H | H | 3-F-2-Me-吡啶-4-基 | 1 |
D-5230 | H | H | H | H | H | 3-F-5-Me-吡啶-4-基 | 1 |
D-5231 | H | H | H | H | H | 3-F-6-Me-吡啶-4-基 | 1 |
D-5232 | H | H | H | H | H | 3-F-2-OMe-吡啶-4-基 | 1 |
D-5233 | H | H | H | H | H | 3-F-5-OMe-吡啶-4-基 | 1 |
D-5234 | H | H | H | H | H | 3-F-6-OMe-吡啶-4-基 | 1 |
D-5235 | H | H | H | H | H | 3-Cl-2-F-吡啶-4-基 | 1 |
D-5236 | H | H | H | H | H | 3-Cl-6-F-吡啶-4-基 | 1 |
D-5237 | H | H | H | H | H | 3-Cl-2-Me-吡啶-4-基 | 1 |
D-5238 | H | H | H | H | H | 3-Cl-5-Me-吡啶-4-基 | 1 |
D-5239 | H | H | H | H | H | 3-Cl-6-Me-吡啶-4-基 | 1 |
D-5240 | H | H | H | H | H | 3-Me-2-F-吡啶-4-基 | 1 |
D-5241 | H | H | H | H | H | 3-Me-6-F-吡啶-4-基 | 1 |
D-5242 | H | H | H | H | H | 3-Me-2-Cl-吡啶-4-基 | 1 |
D-5243 | H | H | H | H | H | 3-Me-6-Cl-吡啶-4-基 | 1 |
D-5244 | H | H | H | H | H | 2,3-(Me)<sub>2</sub>-吡啶-4-基 | 1 |
D-5245 | H | H | H | H | H | 3,5-(Me)<sub>2</sub>-吡啶-4-基 | 1 |
D-5246 | H | H | H | H | H | 3,6-(Me)<sub>2</sub>-吡啶-4-基 | 1 |
D-5247 | H | H | H | H | H | 3-Me-2-OMe-吡啶-4-基 | 1 |
D-5248 | H | H | H | H | H | 3-Me-5-OMe-吡啶-4-基 | 1 |
D-5249 | H | H | H | H | H | 3-Me-6-OMe-吡啶-4-基 | 1 |
D-5250 | H | H | H | H | H | 3-CF<sub>3</sub>-2-F-吡啶-4-基 | 1 |
D-5251 | H | H | H | H | H | 3-CF<sub>3</sub>-5-F-吡啶-4-基 | 1 |
D-5252 | H | H | H | H | H | 3-CF<sub>3</sub>-6-F-吡啶-4-基 | 1 |
D-5253 | H | H | H | H | H | 3-CF<sub>3</sub>-2-Me-吡啶-4-基 | 1 |
D-5254 | H | H | H | H | H | 3-CF<sub>3</sub>-5-Me-吡啶-4-基 | 1 |
D-5255 | H | H | H | H | H | 3-CF<sub>3</sub>-6-Me-吡啶-4-基 | 1 |
D-5256 | H | H | H | H | H | 3-OMe-2-F-吡啶-4-基 | 1 |
D-5257 | H | H | H | H | H | 3-OMe-6-F-吡啶-4-基 | 1 |
D-5258 | H | H | H | H | H | 3-OMe-2-Cl-吡啶-4-基 | 1 |
D-5259 | H | H | H | H | H | 3-OMe-5-Cl-吡啶-4-基 | 1 |
D-5260 | H | H | H | H | H | 3-OMe-6-Cl-吡啶-4-基 | 1 |
D-5261 | H | H | H | H | H | 3-OMe-2-Me-吡啶-4-基 | 1 |
D-5262 | H | H | H | H | H | 3-OMe-6-Me-吡啶-4-基 | 1 |
D-5263 | H | H | H | H | H | 2,3-(OMe)<sub>2</sub>-吡啶-4-基 | 1 |
D-5264 | H | H | H | H | H | 3,5-(OMe)<sub>2</sub>-吡啶-4-基 | 1 |
D-5265 | H | H | H | H | H | 3,6-(OMe)<sub>2</sub>-吡啶-4-基 | 1 |
D-5266 | H | H | H | H | H | 嘧啶-2-基 | 1 |
D-5267 | H | H | H | H | H | 嘧啶-4-基 | 1 |
D-5268 | H | H | H | H | H | 5-F-嘧啶-4-基 | 1 |
D-5269 | H | H | H | H | H | 5-Me-嘧啶-4-基 | 1 |
D-5270 | H | H | H | H | H | 5-CF<sub>3</sub>-嘧啶-4-基 | 1 |
D-5271 | H | H | H | H | H | 5-OMe-嘧啶-4-基 | 1 |
D-5272 | H | H | H | H | H | 嘧啶-5-基 | 1 |
D-5273 | H | H | H | H | H | 4-F-嘧啶-5-基 | 1 |
D-5274 | H | H | H | H | H | 4-Cl-嘧啶-5-基 | 1 |
D-5275 | H | H | H | H | H | 4-Me-嘧啶-5-基 | 1 |
D-5276 | H | H | H | H | H | 4-CF<sub>3</sub>-嘧啶-5-基 | 1 |
D-5277 | H | H | H | H | H | 4-OMe-嘧啶-5-基 | 1 |
D-5278 | H | H | H | H | H | 哒嗪-3-基 | 1 |
D-5279 | H | H | H | H | H | 4-F-哒嗪-3-基 | 1 |
D-5280 | H | H | H | H | H | 4-Cl-哒嗪-3-基 | 1 |
[表254]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-5281 | H | H | H | H | H | 4-Me-哒嗪-3-基 | 1 |
D-5282 | H | H | H | H | H | 4-CF<sub>3</sub>-哒嗪-3-基 | 1 |
D-5283 | H | H | H | H | H | 4-OMe-哒嗪-3-基 | 1 |
D-5284 | H | H | H | H | H | 哒嗪-4-基 | 1 |
D-5285 | H | H | H | H | H | 3-F-哒嗪-4-基 | 1 |
D-5286 | H | H | H | H | H | 3-Cl-哒嗪-4-基 | 1 |
D-5287 | H | H | H | H | H | 3-Me-哒嗪-4-基 | 1 |
D-5288 | H | H | H | H | H | 3-CF<sub>3</sub>-哒嗪-4-基 | 1 |
D-5289 | H | H | H | H | H | 3-OMe-哒嗪-4-基 | 1 |
D-5290 | H | H | H | H | H | 5-F-哒嗪-4-基 | 1 |
D-5291 | H | H | H | H | H | 5-Cl-哒嗪-4-基 | 1 |
D-5292 | H | H | H | H | H | 5-Me-哒嗪-4-基 | 1 |
D-5293 | H | H | H | H | H | 5-CF<sub>3</sub>-哒嗪-4-基 | 1 |
D-5294 | H | H | H | H | H | 5-OMe-哒嗪-4-基 | 1 |
D-5295 | H | H | H | H | H | 噻吩-2-基 | 1 |
D-5296 | H | H | H | H | H | 3-F-噻吩-2-基 | 1 |
D-5297 | H | H | H | H | H | 3-Cl-噻吩-2-基 | 1 |
D-5298 | H | H | H | H | H | 3-Me-噻吩-2-基 | 1 |
D-5299 | H | H | H | H | H | 3-CF<sub>3</sub>-噻吩-2-基 | 1 |
D-5300 | H | H | H | H | H | 3-OMe-噻吩-2-基 | 1 |
D-5301 | H | H | H | H | H | 噻吩-3-基 | 1 |
D-5302 | H | H | H | H | H | 2-F-噻吩-3-基 | 1 |
D-5303 | H | H | H | H | H | 2-Cl-噻吩-3-基 | 1 |
D-5304 | H | H | H | H | H | 2-Me-噻吩-3-基 | 1 |
D-5305 | H | H | H | H | H | 2-CF<sub>3</sub>-噻吩-3-基 | 1 |
D-5306 | H | H | H | H | H | 2-OMe-噻吩-3-基 | 1 |
D-5307 | H | H | H | H | H | 4-F-噻吩-3-基 | 1 |
D-5308 | H | H | H | H | H | 4-Cl-噻吩-3-基 | 1 |
D-5309 | H | H | H | H | H | 4-Me-噻吩-3-基 | 1 |
D-5310 | H | H | H | H | H | 4-CF<sub>3</sub>-噻吩-3-基 | 1 |
D-5311 | H | H | H | H | H | 4-OMe-噻吩-3-基 | 1 |
D-5312 | H | H | H | H | H | 噻唑-2-基 | 1 |
D-5313 | H | H | H | H | H | 噻唑-4-基 | 1 |
D-5314 | H | H | H | H | H | 5-F-噻唑-4-基 | 1 |
D-5315 | H | H | H | H | H | 5-Me-噻唑-4-基 | 1 |
D-5316 | H | H | H | H | H | 5-CF<sub>3</sub>-噻唑-4-基 | 1 |
D-5317 | H | H | H | H | H | 5-OMe-噻唑-4-基 | 1 |
D-5318 | H | H | H | H | H | 噻唑-5-基 | 1 |
D-5319 | H | H | H | H | H | 4-F-噻唑-5-基 | 1 |
D-5320 | H | H | H | H | H | 4-Me-噻唑-5-基 | 1 |
D-5321 | H | H | H | H | H | 4-CF<sub>3</sub>-噻唑-5-基 | 1 |
D-5322 | H | H | H | H | H | 4-OMe-噻唑-5-基 | 1 |
D-5323 | H | H | H | H | H | 1H-吡咯-1-基 | 1 |
D-5324 | H | H | H | H | H | 2-F-1H-吡咯-1-基 | 1 |
D-5325 | H | H | H | H | H | 2-Me-1H-吡咯-1-基 | 1 |
D-5326 | H | H | H | H | H | 2-CF<sub>3</sub>-1H-吡咯-1-基 | 1 |
D-5327 | H | H | H | H | H | 2-OMe-1H-吡咯-1-基 | 1 |
D-5328 | H | H | H | H | H | 1H-吡咯-2-基 | 1 |
D-5329 | H | H | H | H | H | 1-Me-1H-吡咯-2-基 | 1 |
D-5330 | H | H | H | H | H | 3-F-1H-吡咯-2-基 | 1 |
D-5331 | H | H | H | H | H | 3-Me-1H-吡咯-2-基 | 1 |
D-5332 | H | H | H | H | H | 3-CF<sub>3</sub>-1H-吡咯-2-基 | 1 |
D-5333 | H | H | H | H | H | 3-OMe-1H-吡咯-2-基 | 1 |
D-5334 | H | H | H | H | H | 1-Me-3-F-1H-吡咯-2-基 | 1 |
D-5335 | H | H | H | H | H | 1,3-(Me)2-1H-吡咯-2-基 | 1 |
D-5336 | H | H | H | H | H | 1-Me-3-CF<sub>3</sub>-1H-吡咯-2-基 | 1 |
D-5337 | H | H | H | H | H | 1-Me-3-OMe-1H-吡咯-2-基 | 1 |
[表255]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
D-5338 | H | H | H | H | H | 1H-吡咯-3-基 | 1 |
D-5339 | H | H | H | H | H | 1-Me-1H-吡咯-3-基 | 1 |
D-5340 | H | H | H | H | H | 2-F-1H-吡咯-3-基 | 1 |
D-5341 | H | H | H | H | H | 2-Me-1H-吡咯-3-基 | 1 |
D-5342 | H | H | H | H | H | 2-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
D-5343 | H | H | H | H | H | 2-OMe-1H-吡咯-3-基 | 1 |
D-5344 | H | H | H | H | H | 1-Me-2-F-1H-吡咯-3-基 | 1 |
D-5345 | H | H | H | H | H | 1,2-(Me)<sub>2</sub>-1H-吡咯-3-基 | 1 |
D-5346 | H | H | H | H | H | 1-Me-2-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
D-5347 | H | H | H | H | H | 1-Me-2-OMe-1H-吡咯-3-基 | 1 |
D-5348 | H | H | H | H | H | 4-F-1H-吡咯-3-基 | 1 |
D-5349 | H | H | H | H | H | 4-Me-1H-吡咯-3-基 | 1 |
D-5350 | H | H | H | H | H | 4-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
D-5351 | H | H | H | H | H | 4-OMe-1H-吡咯-3-基 | 1 |
D-5352 | H | H | H | H | H | 1-Me-4-F-1H-吡咯-3-基 | 1 |
D-5353 | H | H | H | H | H | 1,4-(Me)<sub>2</sub>-1H-吡咯-3-基 | 1 |
D-5354 | H | H | H | H | H | 1-Me-4-CF3-1H-吡咯-3-基 | 1 |
D-5355 | H | H | H | H | H | 1-Me-4-OMe-1H-吡咯-3-基 | 1 |
D-5356 | H | H | H | H | H | 1H-吡唑-1-基 | 1 |
D-5357 | H | H | H | H | H | 5-F-1H-吡唑-1-基 | 1 |
D-5358 | H | H | H | H | H | 5-Cl-1H-吡唑-1-基 | 1 |
D-5359 | H | H | H | H | H | 5-Me-1H-吡唑-1-基 | 1 |
D-5360 | H | H | H | H | H | 5-CF<sub>3</sub>-1H-吡唑-1-基 | 1 |
D-5361 | H | H | H | H | H | 5-OMe-1H-吡唑-1-基 | 1 |
D-5362 | H | H | H | H | H | 1H-吡唑-3-基 | 1 |
D-5363 | H | H | H | H | H | 1-Me-1H-吡唑-3-基 | 1 |
D-5364 | H | H | H | H | H | 4-F-1H-吡唑-3-基 | 1 |
D-5365 | H | H | H | H | H | 4-Cl-1H-吡唑-3-基 | 1 |
D-5366 | H | H | H | H | H | 4-Me-1H-吡唑-3-基 | 1 |
D-5367 | H | H | H | H | H | 4-CF<sub>3</sub>-1H-吡唑-3-基 | 1 |
D-5368 | H | H | H | H | H | 4-OMe-1H-吡唑-3-基 | 1 |
D-5369 | H | H | H | H | H | 1-Me-4-F-1H-吡唑-3-基 | 1 |
D-5370 | H | H | H | H | H | 1-Me-4-Cl-1H-吡唑-3-基 | 1 |
D-5371 | H | H | H | H | H | 1,4-(Me)<sub>2</sub>-1H-吡唑-3-基 | 1 |
D-5372 | H | H | H | H | H | 1-Me-4-CF3-1H-吡唑-3-基 | 1 |
D-5373 | H | H | H | H | H | 1-Me-4-OMe-1H-吡唑-3-基 | 1 |
D-5374 | H | H | H | H | H | 1H-吡唑-4-基 | 1 |
D-5375 | H | H | H | H | H | 1-Me-1H-吡唑-4-基 | 1 |
D-5376 | H | H | H | H | H | 3-F-1H-吡唑-4-基 | 1 |
D-5377 | H | H | H | H | H | 3-Cl-1H-吡唑-4-基 | 1 |
D-5378 | H | H | H | H | H | 3-Me-1H-吡唑-4-基 | 1 |
D-5379 | H | H | H | H | H | 3-CF3-1H-吡唑-4-基 | 1 |
D-5380 | H | H | H | H | H | 3-OMe-1H-吡唑-4-基 | 1 |
D-5381 | H | H | H | H | H | 1-Me-3-F-1H-吡唑-4-基 | 1 |
D-5382 | H | H | H | H | H | 1-Me-3-Cl-1H-吡唑-4-基 | 1 |
D-5383 | H | H | H | H | H | 1,3-(Me)<sub>2</sub>-1H-吡唑-4-基 | 1 |
D-5384 | H | H | H | H | H | 1-Me-3-CF3-1H-吡唑-4-基 | 1 |
D-5385 | H | H | H | H | H | 1-Me-3-OMe-1H-吡唑-4-基 | 1 |
D-5386 | H | H | H | H | H | 5-F-1H-吡唑-4-基 | 1 |
D-5387 | H | H | H | H | H | 5-Cl-1H-吡唑-4-基 | 1 |
D-5388 | H | H | H | H | H | 5-Me-1H-吡唑-4-基 | 1 |
D-5389 | H | H | H | H | H | 5-CF<sub>3</sub>-1H-吡唑-4-基 | 1 |
D-5390 | H | H | H | H | H | 5-OMe-1H-吡唑-4-基 | 1 |
D-5391 | H | H | H | H | H | 1-Me-5-F-1H-吡唑-4-基 | 1 |
D-5392 | H | H | H | H | H | 1-Me-5-Cl-1H-吡唑-4-基 | 1 |
D-5393 | H | H | H | H | H | 1,5-(Me)<sub>2</sub>-1H-吡唑-4-基 | 1 |
D-5394 | H | H | H | H | H | 1-Me-5-CF<sub>3</sub>-1H-吡唑-4-基 | 1 |
[表256]
[表257]
[表258]
[表259]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0053 | H | H | H | H | H | 2-CF<sub>2</sub>Cl | 0 |
E-0054 | H | H | H | H | H | 3-CF<sub>2</sub>Cl | 0 |
E-0055 | H | H | H | H | H | 4-CF<sub>2</sub>Cl | 0 |
E-0056 | H | H | H | H | H | 2-CF(CF<sub>3</sub>)<sub>2</sub> | 0 |
E-0057 | H | H | H | H | H | 3-CF(CF<sub>3</sub>)<sub>2</sub> | 0 |
E-0058 | H | H | H | H | H | 4-CF(CF<sub>3</sub>)<sub>2</sub> | 0 |
E-0059 | H | H | H | H | H | 2-环丙基 | 0 |
E-0060 | H | H | H | H | H | 3-环丙基 | 0 |
E-0061 | H | H | H | H | H | 4-环丙基 | 0 |
E-0062 | H | H | H | H | H | 2-环丁基 | 0 |
E-0063 | H | H | H | H | H | 3-环丁基 | 0 |
E-0064 | H | H | H | H | H | 4-环丁基 | 0 |
E-0065 | H | H | H | H | H | 2-环戊基 | 0 |
E-0066 | H | H | H | H | H | 3-环戊基 | 0 |
E-0067 | H | H | H | H | H | 4-环戊基 | 0 |
E-0068 | H | H | H | H | H | 2-(环丙基甲基) | 0 |
E-0069 | H | H | H | H | H | 3-(环丙基甲基) | 0 |
E-0070 | H | H | H | H | H | 4-(环丙基甲基) | 0 |
E-0071 | H | H | H | H | H | 2-(环丁基甲基) | 0 |
E-0072 | H | H | H | H | H | 3-(环丁基甲基) | 0 |
E-0073 | H | H | H | H | H | 4-(环丁基甲基) | 0 |
E-0074 | H | H | H | H | H | 2-(环戊基甲基) | 0 |
E-0075 | H | H | H | H | H | 3-(环戊基甲基) | 0 |
E-0076 | H | H | H | H | H | 4-(环戊基甲基) | 0 |
E-0077 | H | H | H | H | H | 2-(环丙基乙基) | 0 |
E-0078 | H | H | H | H | H | 3-(环丙基乙基) | 0 |
E-0079 | H | H | H | H | H | 4-(环丙基乙基) | 0 |
E-0080 | H | H | H | H | H | 2-(2,2-二氟环丙基) | 0 |
E-0081 | H | H | H | H | H | 3-(2,2-二氟环丙基) | 0 |
E-0082 | H | H | H | H | H | 4-(2,2-二氟环丙基) | 0 |
E-0083 | H | H | H | H | H | 2-(2,2-二氯环丙基) | 0 |
E-0084 | H | H | H | H | H | 3-(2,2-二氯环丙基) | 0 |
E-0085 | H | H | H | H | H | 4-(2,2-二氯环丙基) | 0 |
E-0086 | H | H | H | H | H | 2-乙烯基 | 0 |
E-0087 | H | H | H | H | H | 3-乙烯基 | 0 |
E-0088 | H | H | H | H | H | 4-乙烯基 | 0 |
E-0089 | H | H | H | H | H | 2-烯丙基 | 0 |
E-0090 | H | H | H | H | H | 3-烯丙基 | 0 |
E-0091 | H | H | H | H | H | 4-烯丙基 | 0 |
E-0092 | H | H | H | H | H | 2-(丙-1-烯-1-基) | 0 |
E-0093 | H | H | H | H | H | 3-(丙-1-烯-1-基) | 0 |
E-0094 | H | H | H | H | H | 4-(丙-1-烯-1-基) | 0 |
E-0095 | H | H | H | H | H | 2-(三氟乙烯基) | 0 |
E-0096 | H | H | H | H | H | 3-(三氟乙烯基) | 0 |
E-0097 | H | H | H | H | H | 4-(三氟乙烯基) | 0 |
E-0098 | H | H | H | H | H | 2-(2,2-二氯乙烯基) | 0 |
E-0099 | H | H | H | H | H | 3-(2,2-二氯乙烯基) | 0 |
E-0100 | H | H | H | H | H | 4-(2,2-二氯乙烯基) | 0 |
E-0101 | H | H | H | H | H | 2-乙炔基 | 0 |
E-0102 | H | H | H | H | H | 3-乙炔基 | 0 |
E-0103 | H | H | H | H | H | 4-乙炔基 | 0 |
E-0104 | H | H | H | H | H | 2-(1-丙炔-1-基) | 0 |
E-0105 | H | H | H | H | H | 3-(1-丙炔-1-基) | 0 |
E-0106 | H | H | H | H | H | 4-(1-丙炔-1-基) | 0 |
E-0107 | H | H | H | H | H | 2-(2-丙炔-1-基) | 0 |
E-0108 | H | H | H | H | H | 3-(2-丙炔-1-基) | 0 |
E-0109 | H | H | H | H | H | 4-(2-丙炔-1-基) | 0 |
[表260]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0110 | H | H | H | H | H | 2-(2-环丙基乙炔基) | 0 |
E-0111 | H | H | H | H | H | 3-(2-环丙基乙炔基) | 0 |
E-0112 | H | H | H | H | H | 4-(2-环丙基乙炔基) | 0 |
E-0113 | H | H | H | H | H | 2-(2-氯乙炔基) | 0 |
E-0114 | H | H | H | H | H | 3-(2-氯乙炔基) | 0 |
E-0115 | H | H | H | H | H | 4-(2-氯乙炔基) | 0 |
E-0116 | H | H | H | H | H | 2-(2-溴乙炔基) | 0 |
E-0117 | H | H | H | H | H | 3-(2-溴乙炔基) | 0 |
E-0118 | H | H | H | H | H | 4-(2-溴乙炔基) | 0 |
E-0119 | H | H | H | H | H | 2-OMe | 0 |
E-0120 | H | H | H | H | H | 3-OMe | 0 |
E-0121 | H | H | H | H | H | 4-OMe | 0 |
E-0122 | H | H | H | H | H | 2-OEt | 0 |
E-0123 | H | H | H | H | H | 3-OEt | 0 |
E-0124 | H | H | H | H | H | 4-OEt | 0 |
E-0125 | H | H | H | H | H | 2-OPr | 0 |
E-0126 | H | H | H | H | H | 3-OPr | 0 |
E-0127 | H | H | H | H | H | 4-OPr | 0 |
E-0128 | H | H | H | H | H | 2-O(i-Pr) | 0 |
E-0129 | H | H | H | H | H | 3-O(i-Pr) | 0 |
E-0130 | H | H | H | H | H | 4-O(i-Pr) | 0 |
E-0131 | H | H | H | H | H | 2-OBu | 0 |
E-0132 | H | H | H | H | H | 3-OBu | 0 |
E-0133 | H | H | H | H | H | 4-OBu | 0 |
E-0134 | H | H | H | H | H | 2-O(s-Bu) | 0 |
E-0135 | H | H | H | H | H | 3-O(s-Bu) | 0 |
E-0136 | H | H | H | H | H | 4-O(s-Bu) | 0 |
E-0137 | H | H | H | H | H | 2-O(i-Bu) | 0 |
E-0138 | H | H | H | H | H | 3-O(i-Bu) | 0 |
E-0139 | H | H | H | H | H | 4-O(i-Bu) | 0 |
E-0140 | H | H | H | H | H | 2-O(t-Bu) | 0 |
E-0141 | H | H | H | H | H | 3-O(t-Bu) | 0 |
E-0142 | H | H | H | H | H | 4-O(t-Bu) | 0 |
E-0143 | H | H | H | H | H | 2-OCF<sub>3</sub> | 0 |
E-0144 | H | H | H | H | H | 3-OCF<sub>3</sub> | 0 |
E-0145 | H | H | H | H | H | 4-OCF<sub>3</sub> | 0 |
E-0146 | H | H | H | H | H | 2-OCHF<sub>2</sub> | 0 |
E-0147 | H | H | H | H | H | 3-OCHF<sub>2</sub> | 0 |
E-0148 | H | H | H | H | H | 4-OCHF<sub>2</sub> | 0 |
E-0149 | H | H | H | H | H | 2-OCH<sub>2</sub>CF<sub>3</sub> | 0 |
E-0150 | H | H | H | H | H | 3-OCH<sub>2</sub>CF<sub>3</sub> | 0 |
E-0151 | H | H | H | H | H | 4-OCH<sub>2</sub>CF<sub>3</sub> | 0 |
E-0152 | H | H | H | H | H | 2-(环丙基氧基) | 0 |
E-0153 | H | H | H | H | H | 3-(环丙基氧基) | 0 |
E-0154 | H | H | H | H | H | 4-(环丙基氧基) | 0 |
E-0155 | H | H | H | H | H | 2-(环丁基氧基) | 0 |
E-0156 | H | H | H | H | H | 3-(环丁基氧基) | 0 |
E-0157 | H | H | H | H | H | 4-(环丁基氧基) | 0 |
E-0158 | H | H | H | H | H | 2-(环戊基氧基) | 0 |
E-0159 | H | H | H | H | H | 3-(环戊基氧基) | 0 |
E-0160 | H | H | H | H | H | 4-(环戊基氧基) | 0 |
E-0161 | H | H | H | H | H | 2-((2,2-二氯环丙基)氧基) | 0 |
E-0162 | H | H | H | H | H | 3-((2,2-二氯环丙基)氧基) | 0 |
E-0163 | H | H | H | H | H | 4-((2,2-二氯环丙基)氧基) | 0 |
E-0164 | H | H | H | H | H | 2-(环丙基甲氧基) | 0 |
E-0165 | H | H | H | H | H | 3-(环丙基甲氧基) | 0 |
E-0166 | H | H | H | H | H | 4-(环丙基甲氧基) | 0 |
[表261]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0167 | H | H | H | H | H | 2-((2,2-二氟环丙基)甲氧基) | 0 |
E-0168 | H | H | H | H | H | 3-((2,2-二氟环丙基)甲氧基) | 0 |
E-0169 | H | H | H | H | H | 4-((2,2-二氟环丙基)甲氧基) | 0 |
E-0170 | H | H | H | H | H | 2-(环氧乙烷-2-基) | 0 |
E-0171 | H | H | H | H | H | 3-(环氧乙烷-2-基) | 0 |
E-0172 | H | H | H | H | H | 4-(环氧乙烷-2-基) | 0 |
E-0173 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基) | 0 |
E-0174 | H | H | H | H | H | 3-(环氧乙烷-2-基甲基) | 0 |
E-0175 | H | H | H | H | H | 4-(环氧乙烷-2-基甲基) | 0 |
E-0176 | H | H | H | H | H | 2-SMe | 0 |
E-0177 | H | H | H | H | H | 3-SMe | 0 |
E-0178 | H | H | H | H | H | 4-SMe | 0 |
E-0179 | H | H | H | H | H | 2-SEt | 0 |
E-0180 | H | H | H | H | H | 3-SEt | 0 |
E-0181 | H | H | H | H | H | 4-SEt | 0 |
E-0182 | H | H | H | H | H | 2-S(=O)Me | 0 |
E-0183 | H | H | H | H | H | 3-S(=O)Me | 0 |
E-0184 | H | H | H | H | H | 4-S(=O)Me | 0 |
E-0185 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me | 0 |
E-0186 | H | H | H | H | H | 3-S(=O)<sub>2</sub>Me | 0 |
E-0187 | H | H | H | H | H | 4-S(=O)<sub>2</sub>Me | 0 |
E-0188 | H | H | H | H | H | 2-SCF<sub>3</sub> | 0 |
E-0189 | H | H | H | H | H | 3-SCF<sub>3</sub> | 0 |
E-0190 | H | H | H | H | H | 4-SCF<sub>3</sub> | 0 |
E-0191 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub> | 0 |
E-0192 | H | H | H | H | H | 3-S(=O)CF<sub>3</sub> | 0 |
E-0193 | H | H | H | H | H | 4-S(=O)CF<sub>3</sub> | 0 |
E-0194 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
E-0195 | H | H | H | H | H | 3-S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
E-0196 | H | H | H | H | H | 4-S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
E-0197 | H | H | H | H | H | 2-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
E-0198 | H | H | H | H | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
E-0199 | H | H | H | H | H | 4-SCF(CF<sub>3</sub>)<sub>2</sub> | 0 |
E-0200 | H | H | H | H | H | 2-(环丙基硫基) | 0 |
E-0201 | H | H | H | H | H | 3-(环丙基硫基) | 0 |
E-0202 | H | H | H | H | H | 4-(环丙基硫基) | 0 |
E-0203 | H | H | H | H | H | 2-(环丙基亚磺酰基) | 0 |
E-0204 | H | H | H | H | H | 3-(环丙基亚磺酰基) | 0 |
E-0205 | H | H | H | H | H | 4-(环丙基亚磺酰基) | 0 |
E-0206 | H | H | H | H | H | 2-(环丙基磺酰基) | 0 |
E-0207 | H | H | H | H | H | 3-(环丙基磺酰基) | 0 |
E-0208 | H | H | H | H | H | 4-(环丙基磺酰基) | 0 |
E-0209 | H | H | H | H | H | 2-((环丙基甲基)硫基) | 0 |
E-0210 | H | H | H | H | H | 3-((环丙基甲基)硫基) | 0 |
E-0211 | H | H | H | H | H | 4-((环丙基甲基)硫基) | 0 |
E-0212 | H | H | H | H | H | 2-((环丙基甲基)亚磺酰基) | 0 |
E-0213 | H | H | H | H | H | 3-((环丙基甲基)亚磺酰基) | 0 |
E-0214 | H | H | H | H | H | 4-((环丙基甲基)亚磺酰基) | 0 |
E-0215 | H | H | H | H | H | 2-((环丙基甲基)磺酰基) | 0 |
E-0216 | H | H | H | H | H | 3-((环丙基甲基)磺酰基) | 0 |
E-0217 | H | H | H | H | H | 4-((环丙基甲基)磺酰基) | 0 |
E-0218 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)硫基) | 0 |
E-0219 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)硫基) | 0 |
E-0220 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)硫基) | 0 |
E-0221 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)亚磺酰基) | 0 |
E-0222 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)亚磺酰基) | 0 |
E-0223 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)亚磺酰基) | 0 |
[表262]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0224 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)磺酰基) | 0 |
E-0225 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)磺酰基) | 0 |
E-0226 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)磺酰基) | 0 |
E-0227 | H | H | H | H | H | 2-C(=O)Me | 0 |
E-0228 | H | H | H | H | H | 3-C(=O)Me | 0 |
E-0229 | H | H | H | H | H | 4-C(=O)Me | 0 |
E-0230 | H | H | H | H | H | 2-C(=O)Et | 0 |
E-0231 | H | H | H | H | H | 3-C(=O)Et | 0 |
E-0232 | H | H | H | H | H | 4-C(=O)Et | 0 |
E-0233 | H | H | H | H | H | 2-C(=O)CF<sub>3</sub> | 0 |
E-0234 | H | H | H | H | H | 3-C(=O)CF<sub>3</sub> | 0 |
E-0235 | H | H | H | H | H | 4-C(=O)CF<sub>3</sub> | 0 |
E-0236 | H | H | H | H | H | 2-C(=O)OMe | 0 |
E-0237 | H | H | H | H | H | 3-C(=O)OMe | 0 |
E-0238 | H | H | H | H | H | 4-C(=O)OMe | 0 |
E-0239 | H | H | H | H | H | 2-C(=O)OEt | 0 |
E-0240 | H | H | H | H | H | 3-C(=O)OEt | 0 |
E-0241 | H | H | H | H | H | 4-C(=O)OEt | 0 |
E-0242 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub> | 0 |
E-0243 | H | H | H | H | H | 3-C(=O)NH<sub>2</sub> | 0 |
E-0244 | H | H | H | H | H | 4-C(=O)NH<sub>2</sub> | 0 |
E-0245 | H | H | H | H | H | 2-C(=O)NHMe | 0 |
E-0246 | H | H | H | H | H | 3-C(=O)NHMe | 0 |
E-0247 | H | H | H | H | H | 4-C(=O)NHMe | 0 |
E-0248 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub> | 0 |
E-0249 | H | H | H | H | H | 3-C(=O)NMe<sub>2</sub> | 0 |
E-0250 | H | H | H | H | H | 4-C(=O)NMe<sub>2</sub> | 0 |
E-0251 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
E-0252 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
E-0253 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 0 |
E-0254 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
E-0255 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
E-0256 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 0 |
E-0257 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 0 |
E-0258 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 0 |
E-0259 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 0 |
E-0260 | H | H | H | H | H | 2-CH<sub>2</sub>OH | 0 |
E-0261 | H | H | H | H | H | 3-CH<sub>2</sub>OH | 0 |
E-0262 | H | H | H | H | H | 4-CH<sub>2</sub>OH | 0 |
E-0263 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
E-0264 | H | H | H | H | H | 3-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
E-0265 | H | H | H | H | H | 4-CH<sub>2</sub>OCH<sub>3</sub> | 0 |
E-0266 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
E-0267 | H | H | H | H | H | 3-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
E-0268 | H | H | H | H | H | 4-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 0 |
E-0269 | H | H | H | H | H | 2-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 0 |
E-0270 | H | H | H | H | H | 3-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 0 |
E-0271 | H | H | H | H | H | 4-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 0 |
E-0272 | H | H | H | H | H | 2-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 0 |
E-0273 | H | H | H | H | H | 3-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 0 |
E-0274 | H | H | H | H | H | 4-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 0 |
E-0275 | H | H | H | H | H | 2-CH<sub>2</sub>OCF<sub>3</sub> | 0 |
E-0276 | H | H | H | H | H | 3-CH<sub>2</sub>OCF<sub>3</sub> | 0 |
E-0277 | H | H | H | H | H | 4-CH<sub>2</sub>OCF<sub>3</sub> | 0 |
E-0278 | H | H | H | H | H | 2-CF<sub>2</sub>OCH<sub>3</sub> | 0 |
E-0279 | H | H | H | H | H | 3-CF<sub>2</sub>OCH<sub>3</sub> | 0 |
E-0280 | H | H | H | H | H | 4-CF<sub>2</sub>OCH<sub>3</sub> | 0 |
[表263]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0281 | H | H | H | H | H | 2-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 0 |
E-0282 | H | H | H | H | H | 3-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 0 |
E-0283 | H | H | H | H | H | 4-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 0 |
E-0284 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub> | 0 |
E-0285 | H | H | H | H | H | 3-OC(=O)CH<sub>3</sub> | 0 |
E-0286 | H | H | H | H | H | 4-OC(=O)CH<sub>3</sub> | 0 |
E-0287 | H | H | H | H | H | 2-OC(=O)CF<sub>3</sub> | 0 |
E-0288 | H | H | H | H | H | 3-OC(=O)CF<sub>3</sub> | 0 |
E-0289 | H | H | H | H | H | 4-OC(=O)CF<sub>3</sub> | 0 |
E-0290 | H | H | H | H | H | 2-OC(=O)NH<sub>2</sub> | 0 |
E-0291 | H | H | H | H | H | 3-OC(=O)NH<sub>2</sub> | 0 |
E-0292 | H | H | H | H | H | 4-OC(=O)NH<sub>2</sub> | 0 |
E-0293 | H | H | H | H | H | 2-OC(=O)NHCH<sub>3</sub> | 0 |
E-0294 | H | H | H | H | H | 3-OC(=O)NHCH<sub>3</sub> | 0 |
E-0295 | H | H | H | H | H | 4-OC(=O)NHCH<sub>3</sub> | 0 |
E-0296 | H | H | H | H | H | 2-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
E-0297 | H | H | H | H | H | 3-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
E-0298 | H | H | H | H | H | 4-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
E-0299 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 0 |
E-0300 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 0 |
E-0301 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 0 |
E-0302 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 0 |
E-0303 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 0 |
E-0304 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 0 |
E-0305 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
E-0306 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
E-0307 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 0 |
E-0308 | H | H | H | H | H | 2-OC(=O)OCH<sub>3</sub> | 0 |
E-0309 | H | H | H | H | H | 3-OC(=O)OCH<sub>3</sub> | 0 |
E-0310 | H | H | H | H | H | 4-OC(=O)OCH<sub>3</sub> | 0 |
E-0311 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 0 |
E-0312 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 0 |
E-0313 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 0 |
E-0314 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 0 |
E-0315 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 0 |
E-0316 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 0 |
E-0317 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
E-0318 | H | H | H | H | H | 3-OS(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
E-0319 | H | H | H | H | H | 4-OS(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
E-0320 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
E-0321 | H | H | H | H | H | 3-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
E-0322 | H | H | H | H | H | 4-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
E-0323 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
E-0324 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
E-0325 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 0 |
E-0326 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
E-0327 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
E-0328 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 0 |
E-0329 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub> | 0 |
E-0330 | H | H | H | H | H | 3-CH<sub>2</sub>SCF<sub>3</sub> | 0 |
E-0331 | H | H | H | H | H | 4-CH<sub>2</sub>SCF<sub>3</sub> | 0 |
E-0332 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 0 |
E-0333 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 0 |
E-0334 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 0 |
E-0335 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
E-0336 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
E-0337 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 0 |
[表264]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0338 | H | H | H | H | H | 2-苯基 | 0 |
E-0339 | H | H | H | H | H | 3-苯基 | 0 |
E-0340 | H | H | H | H | H | 4-苯基 | 0 |
E-0341 | H | H | H | H | H | 2-(苯氧基) | 0 |
E-0342 | H | H | H | H | H | 3-(苯氧基) | 0 |
E-0343 | H | H | H | H | H | 4-(苯氧基) | 0 |
E-0344 | H | H | H | H | H | 2-苯甲基 | 0 |
E-0345 | H | H | H | H | H | 3-苯甲基 | 0 |
E-0346 | H | H | H | H | H | 4-苯甲基 | 0 |
E-0347 | H | H | H | H | H | 2-(苯甲基氧基) | 0 |
E-0348 | H | H | H | H | H | 3-(苯甲基氧基) | 0 |
E-0349 | H | H | H | H | H | 4-(苯甲基氧基) | 0 |
E-0350 | H | H | H | H | H | 2-((2-氟苯甲基)氧基) | 0 |
E-0351 | H | H | H | H | H | 3-((2-氟苯甲基)氧基) | 0 |
E-0352 | H | H | H | H | H | 4-((2-氟苯甲基)氧基) | 0 |
E-0353 | H | H | H | H | H | 2-((3-氟苯甲基)氧基) | 0 |
E-0354 | H | H | H | H | H | 3-((3-氟苯甲基)氧基) | 0 |
E-0355 | H | H | H | H | H | 4-((3-氟苯甲基)氧基) | 0 |
E-0356 | H | H | H | H | H | 2-((4-氟苯甲基)氧基) | 0 |
E-0357 | H | H | H | H | H | 3-((4-氟苯甲基)氧基) | 0 |
E-0358 | H | H | H | H | H | 4-((4-氟苯甲基)氧基) | 0 |
E-0359 | H | H | H | H | H | 2-((2-氯苯甲基)氧基) | 0 |
E-0360 | H | H | H | H | H | 3-((2-氯苯甲基)氧基) | 0 |
E-0361 | H | H | H | H | H | 4-((2-氯苯甲基)氧基) | 0 |
E-0362 | H | H | H | H | H | 2-((3-氯苯甲基)氧基) | 0 |
E-0363 | H | H | H | H | H | 3-((3-氯苯甲基)氧基) | 0 |
E-0364 | H | H | H | H | H | 4-((3-氯苯甲基)氧基) | 0 |
E-0365 | H | H | H | H | H | 2-((4-氯苯甲基)氧基) | 0 |
E-0366 | H | H | H | H | H | 3-((4-氯苯甲基)氧基) | 0 |
E-0367 | H | H | H | H | H | 4-((4-氯苯甲基)氧基) | 0 |
E-0368 | H | H | H | H | H | 2-((2-甲基苯甲基)氧基) | 0 |
E-0369 | H | H | H | H | H | 3-((2-甲基苯甲基)氧基) | 0 |
E-0370 | H | H | H | H | H | 4-((2-甲基苯甲基)氧基) | 0 |
E-0371 | H | H | H | H | H | 2-((3-甲基苯甲基)氧基) | 0 |
E-0372 | H | H | H | H | H | 3-((3-甲基苯甲基)氧基) | 0 |
E-0373 | H | H | H | H | H | 4-((3-甲基苯甲基)氧基) | 0 |
E-0374 | H | H | H | H | H | 2-((4-甲基苯甲基)氧基) | 0 |
E-0375 | H | H | H | H | H | 3-((4-甲基苯甲基)氧基) | 0 |
E-0376 | H | H | H | H | H | 4-((4-甲基苯甲基)氧基) | 0 |
E-0377 | H | H | H | H | H | 2-((2-(三氟甲基)苯甲基)氧基) | 0 |
E-0378 | H | H | H | H | H | 3-((2-(三氟甲基)苯甲基)氧基) | 0 |
E-0379 | H | H | H | H | H | 4-((2-(三氟甲基)苯甲基)氧基) | 0 |
E-0380 | H | H | H | H | H | 2-((3-(三氟甲基)苯甲基)氧基) | 0 |
E-0381 | H | H | H | H | H | 3-((3-(三氟甲基)苯甲基)氧基) | 0 |
E-0382 | H | H | H | H | H | 4-((3-(三氟甲基)苯甲基)氧基) | 0 |
E-0383 | H | H | H | H | H | 2-((4-(三氟甲基)苯甲基)氧基) | 0 |
E-0384 | H | H | H | H | H | 3-((4-(三氟甲基)苯甲基)氧基) | 0 |
E-0385 | H | H | H | H | H | 4-((4-(三氟甲基)苯甲基)氧基) | 0 |
E-0386 | H | H | H | H | H | 2-((2-甲氧基苯甲基)氧基) | 0 |
E-0387 | H | H | H | H | H | 3-((2-甲氧基苯甲基)氧基) | 0 |
E-0388 | H | H | H | H | H | 4-((2-甲氧基苯甲基)氧基) | 0 |
E-0389 | H | H | H | H | H | 2-((3-甲氧基苯甲基)氧基) | 0 |
E-0390 | H | H | H | H | H | 3-((3-甲氧基苯甲基)氧基) | 0 |
E-0391 | H | H | H | H | H | 4-((3-甲氧基苯甲基)氧基) | 0 |
E-0392 | H | H | H | H | H | 2-((4-甲氧基苯甲基)氧基) | 0 |
E-0393 | H | H | H | H | H | 3-((4-甲氧基苯甲基)氧基) | 0 |
E-0394 | H | H | H | H | H | 4-((4-甲氧基苯甲基)氧基) | 0 |
[表265]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0395 | H | H | H | H | H | 2-((2-(三氟甲氧基)苯甲基)氧基) | 0 |
E-0396 | H | H | H | H | H | 3-((2-(三氟甲氧基)苯甲基)氧基) | 0 |
E-0397 | H | H | H | H | H | 4-((2-(三氟甲氧基)苯甲基)氧基) | 0 |
E-0398 | H | H | H | H | H | 2-((3-(三氟甲氧基)苯甲基)氧基) | 0 |
E-0399 | H | H | H | H | H | 3-((3-(三氟甲氧基)苯甲基)氧基) | 0 |
E-0400 | H | H | H | H | H | 4-((3-(三氟甲氧基)苯甲基)氧基) | 0 |
E-0401 | H | H | H | H | H | 2-((4-(三氟甲氧基)苯甲基)氧基) | 0 |
E-0402 | H | H | H | H | H | 3-((4-(三氟甲氧基)苯甲基)氧基) | 0 |
E-0403 | H | H | H | H | H | 4-((4-(三氟甲氧基)苯甲基)氧基) | 0 |
E-0404 | H | H | H | H | H | 2-((2-(甲基硫基)苯甲基)氧基) | 0 |
E-0405 | H | H | H | H | H | 3-((2-(甲基硫基)苯甲基)氧基) | 0 |
E-0406 | H | H | H | H | H | 4-((2-(甲基硫基)苯甲基)氧基) | 0 |
E-0407 | H | H | H | H | H | 2-((3-(甲基硫基)苯甲基)氧基) | 0 |
E-0408 | H | H | H | H | H | 3-((3-(甲基硫基)苯甲基)氧基) | 0 |
E-0409 | H | H | H | H | H | 4-((3-(甲基硫基)苯甲基)氧基) | 0 |
E-0410 | H | H | H | H | H | 2-((4-(甲基硫基)苯甲基)氧基) | 0 |
E-0411 | H | H | H | H | H | 3-((4-(甲基硫基)苯甲基)氧基) | 0 |
E-0412 | H | H | H | H | H | 4-((4-(甲基硫基)苯甲基)氧基) | 0 |
E-0413 | H | H | H | H | H | 2-((2-(甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0414 | H | H | H | H | H | 3-((2-(甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0415 | H | H | H | H | H | 4-((2-(甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0416 | H | H | H | H | H | 2-((3-(甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0417 | H | H | H | H | H | 3-((3-(甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0418 | H | H | H | H | H | 4-((3-(甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0419 | H | H | H | H | H | 2-((4-(甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0420 | H | H | H | H | H | 3-((4-(甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0421 | H | H | H | H | H | 4-((4-(甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0422 | H | H | H | H | H | 2-((2-(甲基磺酰基)苯甲基)氧基) | 0 |
E-0423 | H | H | H | H | H | 3-((2-(甲基磺酰基)苯甲基)氧基) | 0 |
E-0424 | H | H | H | H | H | 4-((2-(甲基磺酰基)苯甲基)氧基) | 0 |
E-0425 | H | H | H | H | H | 2-((3-(甲基磺酰基)苯甲基)氧基) | 0 |
E-0426 | H | H | H | H | H | 3-((3-(甲基磺酰基)苯甲基)氧基) | 0 |
E-0427 | H | H | H | H | H | 4-((3-(甲基磺酰基)苯甲基)氧基) | 0 |
E-0428 | H | H | H | H | H | 2-((4-(甲基磺酰基)苯甲基)氧基) | 0 |
E-0429 | H | H | H | H | H | 3-((4-(甲基磺酰基)苯甲基)氧基) | 0 |
E-0430 | H | H | H | H | H | 4-((4-(甲基磺酰基)苯甲基)氧基) | 0 |
E-0431 | H | H | H | H | H | 2-((2-(三氟甲基硫基)苯甲基)氧基) | 0 |
E-0432 | H | H | H | H | H | 3-((2-(三氟甲基硫基)苯甲基)氧基) | 0 |
E-0433 | H | H | H | H | H | 4-((2-(三氟甲基硫基)苯甲基)氧基) | 0 |
E-0434 | H | H | H | H | H | 2-((3-(三氟甲基硫基)苯甲基)氧基) | 0 |
E-0435 | H | H | H | H | H | 3-((3-(三氟甲基硫基)苯甲基)氧基) | 0 |
E-0436 | H | H | H | H | H | 4-((3-(三氟甲基硫基)苯甲基)氧基) | 0 |
E-0437 | H | H | H | H | H | 2-((4-(三氟甲基硫基)苯甲基)氧基) | 0 |
E-0438 | H | H | H | H | H | 3-((4-(三氟甲基硫基)苯甲基)氧基) | 0 |
E-0439 | H | H | H | H | H | 4-((4-(三氟甲基硫基)苯甲基)氧基) | 0 |
E-0440 | H | H | H | H | H | 2-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0441 | H | H | H | H | H | 3-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0442 | H | H | H | H | H | 4-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0443 | H | H | H | H | H | 2-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0444 | H | H | H | H | H | 3-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0445 | H | H | H | H | H | 4-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0446 | H | H | H | H | H | 2-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0447 | H | H | H | H | H | 3-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0448 | H | H | H | H | H | 4-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 0 |
E-0449 | H | H | H | H | H | 2-((2-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
E-0450 | H | H | H | H | H | 3-((2-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
E-0451 | H | H | H | H | H | 4-((2-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
[表266]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0452 | H | H | H | H | H | 2-((3-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
E-0453 | H | H | H | H | H | 3-((3-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
E-0454 | H | H | H | H | H | 4-((3-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
E-0455 | H | H | H | H | H | 2-((4-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
E-0456 | H | H | H | H | H | 3-((4-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
E-0457 | H | H | H | H | H | 4-((4-(三氟甲基磺酰基)苯甲基)氧基) | 0 |
E-0458 | H | H | H | H | H | 2-((2-氨基苯甲基)氧基) | 0 |
E-0459 | H | H | H | H | H | 3-((2-氨基苯甲基)氧基) | 0 |
E-0460 | H | H | H | H | H | 4-((2-氨基苯甲基)氧基) | 0 |
E-0461 | H | H | H | H | H | 2-((3-氨基苯甲基)氧基) | 0 |
E-0462 | H | H | H | H | H | 3-((3-氨基苯甲基)氧基) | 0 |
E-0463 | H | H | H | H | H | 4-((3-氨基苯甲基)氧基) | 0 |
E-0464 | H | H | H | H | H | 2-((4-氨基苯甲基)氧基) | 0 |
E-0465 | H | H | H | H | H | 3-((4-氨基苯甲基)氧基) | 0 |
E-0466 | H | H | H | H | H | 4-((4-氨基苯甲基)氧基) | 0 |
E-0467 | H | H | H | H | H | 2-((2-(甲基氨基)苯甲基)氧基) | 0 |
E-0468 | H | H | H | H | H | 3-((2-(甲基氨基)苯甲基)氧基) | 0 |
E-0469 | H | H | H | H | H | 4-((2-(甲基氨基)苯甲基)氧基) | 0 |
E-0470 | H | H | H | H | H | 2-((3-(甲基氨基)苯甲基)氧基) | 0 |
E-0471 | H | H | H | H | H | 3-((3-(甲基氨基)苯甲基)氧基) | 0 |
E-0472 | H | H | H | H | H | 4-((3-(甲基氨基)苯甲基)氧基) | 0 |
E-0473 | H | H | H | H | H | 2-((4-(甲基氨基)苯甲基)氧基) | 0 |
E-0474 | H | H | H | H | H | 3-((4-(甲基氨基)苯甲基)氧基) | 0 |
E-0475 | H | H | H | H | H | 4-((4-(甲基氨基)苯甲基)氧基) | 0 |
E-0476 | H | H | H | H | H | 2-((2-(二甲基氨基)苯甲基)氧基) | 0 |
E-0477 | H | H | H | H | H | 3-((2-(二甲基氨基)苯甲基)氧基) | 0 |
E-0478 | H | H | H | H | H | 4-((2-(二甲基氨基)苯甲基)氧基) | 0 |
E-0479 | H | H | H | H | H | 2-((3-(二甲基氨基)苯甲基)氧基) | 0 |
E-0480 | H | H | H | H | H | 3-((3-(二甲基氨基)苯甲基)氧基) | 0 |
E-0481 | H | H | H | H | H | 4-((3-(二甲基氨基)苯甲基)氧基) | 0 |
E-0482 | H | H | H | H | H | 2-((4-(二甲基氨基)苯甲基)氧基) | 0 |
E-0483 | H | H | H | H | H | 3-((4-(二甲基氨基)苯甲基)氧基) | 0 |
E-0484 | H | H | H | H | H | 4-((4-(二甲基氨基)苯甲基)氧基) | 0 |
E-0485 | H | H | H | H | H | 2-((2-氰基苯甲基)氧基) | 0 |
E-0486 | H | H | H | H | H | 3-((2-氰基苯甲基)氧基) | 0 |
E-0487 | H | H | H | H | H | 4-((2-氰基苯甲基)氧基) | 0 |
E-0488 | H | H | H | H | H | 2-((3-氰基苯甲基)氧基) | 0 |
E-0489 | H | H | H | H | H | 3-((3-氰基苯甲基)氧基) | 0 |
E-0490 | H | H | H | H | H | 4-((3-氰基苯甲基)氧基) | 0 |
E-0491 | H | H | H | H | H | 2-((4-氰基苯甲基)氧基) | 0 |
E-0492 | H | H | H | H | H | 3-((4-氰基苯甲基)氧基) | 0 |
E-0493 | H | H | H | H | H | 4-((4-氰基苯甲基)氧基) | 0 |
E-0494 | H | H | H | H | H | 2-((2-硝基苯甲基)氧基) | 0 |
E-0495 | H | H | H | H | H | 3-((2-硝基苯甲基)氧基) | 0 |
E-0496 | H | H | H | H | H | 4-((2-硝基苯甲基)氧基) | 0 |
E-0497 | H | H | H | H | H | 2-((3-硝基苯甲基)氧基) | 0 |
E-0498 | H | H | H | H | H | 3-((3-硝基苯甲基)氧基) | 0 |
E-0499 | H | H | H | H | H | 4-((3-硝基苯甲基)氧基) | 0 |
E-0500 | H | H | H | H | H | 2-((4-硝基苯甲基)氧基) | 0 |
E-0501 | H | H | H | H | H | 3-((4-硝基苯甲基)氧基) | 0 |
E-0502 | H | H | H | H | H | 4-((4-硝基苯甲基)氧基) | 0 |
E-0503 | H | H | H | H | H | 2-NH2 | 0 |
E-0504 | H | H | H | H | H | 3-NH2 | 0 |
E-0505 | H | H | H | H | H | 4-NH2 | 0 |
E-0506 | H | H | H | H | H | 2-NHMe | 0 |
E-0507 | H | H | H | H | H | 3-NHMe | 0 |
E-0508 | H | H | H | H | H | 4-NHMe | 0 |
[表267]
[表268]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0566 | H | H | H | H | H | 3-F,5-Cl | 0 |
E-0567 | H | H | H | H | H | 3-F,6-Cl | 0 |
E-0568 | H | H | H | H | H | 4-F,2-Cl | 0 |
E-0569 | H | H | H | H | H | 4-F,3-Cl | 0 |
E-0570 | H | H | H | H | H | 2-F,3-Me | 0 |
E-0571 | H | H | H | H | H | 2-F,4-Me | 0 |
E-0572 | H | H | H | H | H | 2-F,5-Me | 0 |
E-0573 | H | H | H | H | H | 2-F,6-Me | 0 |
E-0574 | H | H | H | H | H | 3-F,2-Me | 0 |
E-0575 | H | H | H | H | H | 3-F,4-Me | 0 |
E-0576 | H | H | H | H | H | 3-F,5-Me | 0 |
E-0577 | H | H | H | H | H | 3-F,6-Me | 0 |
E-0578 | H | H | H | H | H | 4-F,2-Me | 0 |
E-0579 | H | H | H | H | H | 4-F,3-Me | 0 |
E-0580 | H | H | H | H | H | 2-F,3-CF<sub>3</sub> | 0 |
E-0581 | H | H | H | H | H | 2-F,4-CF<sub>3</sub> | 0 |
E-0582 | H | H | H | H | H | 2-F,5-CF<sub>3</sub> | 0 |
E-0583 | H | H | H | H | H | 2-F,6-CF<sub>3</sub> | 0 |
E-0584 | H | H | H | H | H | 3-F,2-CF<sub>3</sub> | 0 |
E-0585 | H | H | H | H | H | 3-F,4-CF<sub>3</sub> | 0 |
E-0586 | H | H | H | H | H | 3-F,5-CF<sub>3</sub> | 0 |
E-0587 | H | H | H | H | H | 3-F,6-CF<sub>3</sub> | 0 |
E-0588 | H | H | H | H | H | 4-F,2-CF<sub>3</sub> | 0 |
E-0589 | H | H | H | H | H | 4-F,3-CF<sub>3</sub> | 0 |
E-0590 | H | H | H | H | H | 2-F,3-OMe | 0 |
E-0591 | H | H | H | H | H | 2-F,4-OMe | 0 |
E-0592 | H | H | H | H | H | 2-F,5-OMe | 0 |
E-0593 | H | H | H | H | H | 2-F,6-OMe | 0 |
E-0594 | H | H | H | H | H | 3-F,2-OMe | 0 |
E-0595 | H | H | H | H | H | 3-F,4-OMe | 0 |
E-0596 | H | H | H | H | H | 3-F,5-OMe | 0 |
E-0597 | H | H | H | H | H | 3-F,6-OMe | 0 |
E-0598 | H | H | H | H | H | 4-F,2-OMe | 0 |
E-0599 | H | H | H | H | H | 4-F,3-OMe | 0 |
E-0600 | H | H | H | H | H | 2,3-Cl<sub>2</sub> | 0 |
E-0601 | H | H | H | H | H | 2,4-Cl<sub>2</sub> | 0 |
E-0602 | H | H | H | H | H | 2,5-Cl<sub>2</sub> | 0 |
E-0603 | H | H | H | H | H | 2,6-Cl<sub>2</sub> | 0 |
E-0604 | H | H | H | H | H | 3,4-Cl<sub>2</sub> | 0 |
E-0605 | H | H | H | H | H | 3,5-Cl<sub>2</sub> | 0 |
E-0606 | H | H | H | H | H | 2-Cl,3-Me | 0 |
E-0607 | H | H | H | H | H | 2-Cl,4-Me | 0 |
E-0608 | H | H | H | H | H | 2-Cl,5-Me | 0 |
E-0609 | H | H | H | H | H | 2-Cl,6-Me | 0 |
E-0610 | H | H | H | H | H | 3-Cl,2-Me | 0 |
E-0611 | H | H | H | H | H | 3-Cl,4-Me | 0 |
E-0612 | H | H | H | H | H | 3-Cl,5-Me | 0 |
E-0613 | H | H | H | H | H | 3-Cl,6-Me | 0 |
E-0614 | H | H | H | H | H | 4-Cl,2-Me | 0 |
E-0615 | H | H | H | H | H | 4-Cl,3-Me | 0 |
E-0616 | H | H | H | H | H | 2-Cl,3-CF<sub>3</sub> | 0 |
E-0617 | H | H | H | H | H | 2-Cl,4-CF<sub>3</sub> | 0 |
E-0618 | H | H | H | H | H | 2-Cl,5-CF<sub>3</sub> | 0 |
E-0619 | H | H | H | H | H | 2-Cl,6-CF<sub>3</sub> | 0 |
E-0620 | H | H | H | H | H | 3-Cl,2-CF<sub>3</sub> | 0 |
E-0621 | H | H | H | H | H | 3-Cl,4-CF<sub>3</sub> | 0 |
E-0622 | H | H | H | H | H | 3-Cl,5-CF<sub>3</sub> | 0 |
[表269]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0623 | H | H | H | H | H | 3-Cl,6-CF<sub>3</sub> | 0 |
E-0624 | H | H | H | H | H | 4-Cl,2-CF<sub>3</sub> | 0 |
E-0625 | H | H | H | H | H | 4-Cl,3-CF<sub>3</sub> | 0 |
E-0626 | H | H | H | H | H | 2-Cl,3-OMe | 0 |
E-0627 | H | H | H | H | H | 2-Cl,4-OMe | 0 |
E-0628 | H | H | H | H | H | 2-Cl,5-OMe | 0 |
E-0629 | H | H | H | H | H | 2-Cl,6-OMe | 0 |
E-0630 | H | H | H | H | H | 3-Cl,2-OMe | 0 |
E-0631 | H | H | H | H | H | 3-Cl,4-OMe | 0 |
E-0632 | H | H | H | H | H | 3-Cl,5-OMe | 0 |
E-0633 | H | H | H | H | H | 3-Cl,6-OMe | 0 |
E-0634 | H | H | H | H | H | 4-Cl,2-OMe | 0 |
E-0635 | H | H | H | H | H | 4-Cl,3-OMe | 0 |
E-0636 | H | H | H | H | H | 2,3-Me<sub>2</sub> | 0 |
E-0637 | H | H | H | H | H | 2,4-Me<sub>2</sub> | 0 |
E-0638 | H | H | H | H | H | 2,5-Me<sub>2</sub> | 0 |
E-0639 | H | H | H | H | H | 2,6-Me<sub>2</sub> | 0 |
E-0640 | H | H | H | H | H | 3,4-Me<sub>2</sub> | 0 |
E-0641 | H | H | H | H | H | 3,5-Me<sub>2</sub> | 0 |
E-0642 | H | H | H | H | H | 2-Me,3-CF<sub>3</sub> | 0 |
E-0643 | H | H | H | H | H | 2-Me,4-CF<sub>3</sub> | 0 |
E-0644 | H | H | H | H | H | 2-Me,5-CF<sub>3</sub> | 0 |
E-0645 | H | H | H | H | H | 2-Me,6-CF<sub>3</sub> | 0 |
E-0646 | H | H | H | H | H | 3-Me,2-CF<sub>3</sub> | 0 |
E-0647 | H | H | H | H | H | 3-Me,4-CF<sub>3</sub> | 0 |
E-0648 | H | H | H | H | H | 3-Me,5-CF<sub>3</sub> | 0 |
E-0649 | H | H | H | H | H | 3-Me,6-CF<sub>3</sub> | 0 |
E-0650 | H | H | H | H | H | 4-Me,2-CF<sub>3</sub> | 0 |
E-0651 | H | H | H | H | H | 4-Me,3-CF<sub>3</sub> | 0 |
E-0652 | H | H | H | H | H | 2-Me,3-OMe | 0 |
E-0653 | H | H | H | H | H | 2-Me,4-OMe | 0 |
E-0654 | H | H | H | H | H | 2-Me,5-OMe | 0 |
E-0655 | H | H | H | H | H | 2-Me,6-OMe | 0 |
E-0656 | H | H | H | H | H | 3-Me,2-OMe | 0 |
E-0657 | H | H | H | H | H | 3-Me,4-OMe | 0 |
E-0658 | H | H | H | H | H | 3-Me,5-OMe | 0 |
E-0659 | H | H | H | H | H | 3-Me,6-OMe | 0 |
E-0660 | H | H | H | H | H | 4-Me,2-OMe | 0 |
E-0661 | H | H | H | H | H | 4-Me,3-OMe | 0 |
E-0662 | H | H | H | H | H | 2,3-OMe<sub>2</sub> | 0 |
E-0663 | H | H | H | H | H | 2,4-OMe<sub>2</sub> | 0 |
E-0664 | H | H | H | H | H | 2,5-OMe<sub>2</sub> | 0 |
E-0665 | H | H | H | H | H | 2,6-OMe<sub>2</sub> | 0 |
E-0666 | H | H | H | H | H | 3,4-OMe<sub>2</sub> | 0 |
E-0667 | H | H | H | H | H | 3,5-OMe<sub>2</sub> | 0 |
E-0668 | H | H | H | H | H | 2-OMe,3-CF<sub>3</sub> | 0 |
E-0669 | H | H | H | H | H | 2-OMe,4-CF<sub>3</sub> | 0 |
E-0670 | H | H | H | H | H | 2-OMe,5-CF<sub>3</sub> | 0 |
E-0671 | H | H | H | H | H | 2-OMe,6-CF<sub>3</sub> | 0 |
E-0672 | H | H | H | H | H | 3-OMe,2-CF<sub>3</sub> | 0 |
E-0673 | H | H | H | H | H | 3-OMe,4-CF<sub>3</sub> | 0 |
E-0674 | H | H | H | H | H | 3-OMe,5-CF<sub>3</sub> | 0 |
E-0675 | H | H | H | H | H | 3-OMe,6-CF<sub>3</sub> | 0 |
E-0676 | H | H | H | H | H | 4-OMe,2-CF<sub>3</sub> | 0 |
E-0677 | H | H | H | H | H | 4-OMe,3-CF<sub>3</sub> | 0 |
E-0678 | H | H | H | H | H | 2-CHF<sub>2</sub>,3-F | 0 |
E-0679 | H | H | H | H | H | 2-CHF<sub>2</sub>,4-F | 0 |
[表270]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0680 | H | H | H | H | H | 2-CHF<sub>2</sub>,5-F | 0 |
E-0681 | H | H | H | H | H | 2-CHF<sub>2</sub>,6-F | 0 |
E-0682 | H | H | H | H | H | 2-CHF<sub>2</sub>,3-Me | 0 |
E-0683 | H | H | H | H | H | 2-CHF<sub>2</sub>,4-Me | 0 |
E-0684 | H | H | H | H | H | 2-CHF<sub>2</sub>,5-Me | 0 |
E-0685 | H | H | H | H | H | 2-CHF<sub>2</sub>,6-Me | 0 |
E-0686 | H | H | H | H | H | 2-环丙基,3-F | 0 |
E-0687 | H | H | H | H | H | 2-环丙基,4-F | 0 |
E-0688 | H | H | H | H | H | 2-环丙基,5-F | 0 |
E-0689 | H | H | H | H | H | 2-环丙基,6-F | 0 |
E-0690 | H | H | H | H | H | 2-环丙基,3-Me | 0 |
E-0691 | H | H | H | H | H | 2-环丙基,4-Me | 0 |
E-0692 | H | H | H | H | H | 2-环丙基,5-Me | 0 |
E-0693 | H | H | H | H | H | 2-环丙基,6-Me | 0 |
E-0694 | H | H | H | H | H | 2-乙烯基,3-F | 0 |
E-0695 | H | H | H | H | H | 2-乙烯基,4-F | 0 |
E-0696 | H | H | H | H | H | 2-乙烯基,5-F | 0 |
E-0697 | H | H | H | H | H | 2-乙烯基,6-F | 0 |
E-0698 | H | H | H | H | H | 2-乙烯基,3-Me | 0 |
E-0699 | H | H | H | H | H | 2-乙烯基,4-Me | 0 |
E-0700 | H | H | H | H | H | 2-乙烯基,5-Me | 0 |
E-0701 | H | H | H | H | H | 2-乙烯基,6-Me | 0 |
E-0702 | H | H | H | H | H | 2-OEt,3-F | 0 |
E-0703 | H | H | H | H | H | 2-OEt,4-F | 0 |
E-0704 | H | H | H | H | H | 2-OEt,5-F | 0 |
E-0705 | H | H | H | H | H | 2-OEt,6-F | 0 |
E-0706 | H | H | H | H | H | 2-OEt,3-Cl | 0 |
E-0707 | H | H | H | H | H | 2-OEt,4-Cl | 0 |
E-0708 | H | H | H | H | H | 2-OEt,5-Cl | 0 |
E-0709 | H | H | H | H | H | 2-OEt,6-Cl | 0 |
E-0710 | H | H | H | H | H | 2-OEt,3-Me | 0 |
E-0711 | H | H | H | H | H | 2-OEt,4-Me | 0 |
E-0712 | H | H | H | H | H | 2-OEt,5-Me | 0 |
E-0713 | H | H | H | H | H | 2-OEt,6-Me | 0 |
E-0714 | H | H | H | H | H | 2-OPr,3-F | 0 |
E-0715 | H | H | H | H | H | 2-OPr,4-F | 0 |
E-0716 | H | H | H | H | H | 2-OPr,5-F | 0 |
E-0717 | H | H | H | H | H | 2-OPr,6-F | 0 |
E-0718 | H | H | H | H | H | 2-OPr,3-Me | 0 |
E-0719 | H | H | H | H | H | 2-OPr,4-Me | 0 |
E-0720 | H | H | H | H | H | 2-OPr,5-Me | 0 |
E-0721 | H | H | H | H | H | 2-OPr,6-Me | 0 |
E-0722 | H | H | H | H | H | 2-O(i-Pr),3-F | 0 |
E-0723 | H | H | H | H | H | 2-O(i-Pr),4-F | 0 |
E-0724 | H | H | H | H | H | 2-O(i-Pr),5-F | 0 |
E-0725 | H | H | H | H | H | 2-O(i-Pr),6-F | 0 |
E-0726 | H | H | H | H | H | 2-O(i-Pr),3-Me | 0 |
E-0727 | H | H | H | H | H | 2-O(i-Pr),4-Me | 0 |
E-0728 | H | H | H | H | H | 2-O(i-Pr),5-Me | 0 |
E-0729 | H | H | H | H | H | 2-O(i-Pr),6-Me | 0 |
E-0730 | H | H | H | H | H | 2-OCF<sub>3</sub>,3-F | 0 |
E-0731 | H | H | H | H | H | 2-OCF<sub>3</sub>,4-F | 0 |
E-0732 | H | H | H | H | H | 2-OCF<sub>3</sub>,5-F | 0 |
E-0733 | H | H | H | H | H | 2-OCF<sub>3</sub>,6-F | 0 |
E-0734 | H | H | H | H | H | 2-OCF<sub>3</sub>,3-Me | 0 |
E-0735 | H | H | H | H | H | 2-OCF<sub>3</sub>,4-Me | 0 |
E-0736 | H | H | H | H | H | 2-OCF<sub>3</sub>,5-Me | 0 |
[表271]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0737 | H | H | H | H | H | 2-OCF<sub>3</sub>,6-Me | 0 |
E-0738 | H | H | H | H | H | 2-OCHF<sub>2</sub>,3-F | 0 |
E-0739 | H | H | H | H | H | 2-OCHF<sub>2</sub>,4-F | 0 |
E-0740 | H | H | H | H | H | 2-OCHF<sub>2</sub>,5-F | 0 |
E-0741 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-F | 0 |
E-0742 | H | H | H | H | H | 2-OCHF<sub>2</sub>,3-Me | 0 |
E-0743 | H | H | H | H | H | 2-OCHF<sub>2</sub>,4-Me | 0 |
E-0744 | H | H | H | H | H | 2-OCHF<sub>2</sub>,5-Me | 0 |
E-0745 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-Me | 0 |
E-0746 | H | H | H | H | H | 2-(环丙基氧基),3-F | 0 |
E-0747 | H | H | H | H | H | 2-(环丙基氧基),4-F | 0 |
E-0748 | H | H | H | H | H | 2-(环丙基氧基),5-F | 0 |
E-0749 | H | H | H | H | H | 2-(环丙基氧基),6-F | 0 |
E-0750 | H | H | H | H | H | 2-(环丙基氧基),3-Me | 0 |
E-0751 | H | H | H | H | H | 2-(环丙基氧基),4-Me | 0 |
E-0752 | H | H | H | H | H | 2-(环丙基氧基),5-Me | 0 |
E-0753 | H | H | H | H | H | 2-(环丙基氧基),6-Me | 0 |
E-0754 | H | H | H | H | H | 2-(环氧乙烷-2-基),3-F | 0 |
E-0755 | H | H | H | H | H | 2-(环氧乙烷-2-基),4-F | 0 |
E-0756 | H | H | H | H | H | 2-(环氧乙烷-2-基),5-F | 0 |
E-0757 | H | H | H | H | H | 2-(环氧乙烷-2-基),6-F | 0 |
E-0758 | H | H | H | H | H | 2-(环氧乙烷-2-基),3-Me | 0 |
E-0759 | H | H | H | H | H | 2-(环氧乙烷-2-基),4-Me | 0 |
E-0760 | H | H | H | H | H | 2-(环氧乙烷-2-基),5-Me | 0 |
E-0761 | H | H | H | H | H | 2-(环氧乙烷-2-基),6-Me | 0 |
E-0762 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),3-F | 0 |
E-0763 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),4-F | 0 |
E-0764 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),5-F | 0 |
E-0765 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),6-F | 0 |
E-0766 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),3-Me | 0 |
E-0767 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),4-Me | 0 |
E-0768 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),5-Me | 0 |
E-0769 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),6-Me | 0 |
E-0770 | H | H | H | H | H | 2-SMe,3-F | 0 |
E-0771 | H | H | H | H | H | 2-SMe,4-F | 0 |
E-0772 | H | H | H | H | H | 2-SMe,5-F | 0 |
E-0773 | H | H | H | H | H | 2-SMe,6-F | 0 |
E-0774 | H | H | H | H | H | 2-SMe,3-Me | 0 |
E-0775 | H | H | H | H | H | 2-SMe,4-Me | 0 |
E-0776 | H | H | H | H | H | 2-SMe,5-Me | 0 |
E-0777 | H | H | H | H | H | 2-SMe,6-Me | 0 |
E-0778 | H | H | H | H | H | 2-SEt,3-F | 0 |
E-0779 | H | H | H | H | H | 2-SEt,4-F | 0 |
E-0780 | H | H | H | H | H | 2-SEt,5-F | 0 |
E-0781 | H | H | H | H | H | 2-SEt,6-F | 0 |
E-0782 | H | H | H | H | H | 2-SEt,3-Me | 0 |
E-0783 | H | H | H | H | H | 2-SEt,4-Me | 0 |
E-0784 | H | H | H | H | H | 2-SEt,5-Me | 0 |
E-0785 | H | H | H | H | H | 2-SEt,6-Me | 0 |
E-0786 | H | H | H | H | H | 2-S(=O)Me,3-F | 0 |
E-0787 | H | H | H | H | H | 2-S(=O)Me,4-F | 0 |
E-0788 | H | H | H | H | H | 2-S(=O)Me,5-F | 0 |
E-0789 | H | H | H | H | H | 2-S(=O)Me,6-F | 0 |
E-0790 | H | H | H | H | H | 3-S(=O)Me,2-F | 0 |
E-0791 | H | H | H | H | H | 3-S(=O)Me,4-F | 0 |
E-0792 | H | H | H | H | H | 3-S(=O)Me,5-F | 0 |
E-0793 | H | H | H | H | H | 3-S(=O)Me,6-F | 0 |
[表272]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0794 | H | H | H | H | H | 2-S(=O)Me,3-Me | 0 |
E-0795 | H | H | H | H | H | 2-S(=O)Me,4-Me | 0 |
E-0796 | H | H | H | H | H | 2-S(=O)Me,5-Me | 0 |
E-0797 | H | H | H | H | H | 2-S(=O)Me,6-Me | 0 |
E-0798 | H | H | H | H | H | 3-S(=O)Me,2-Me | 0 |
E-0799 | H | H | H | H | H | 3-S(=O)Me,4-Me | 0 |
E-0800 | H | H | H | H | H | 3-S(=O)Me,5-Me | 0 |
E-0801 | H | H | H | H | H | 3-S(=O)Me,6-Me | 0 |
E-0802 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,3-F | 0 |
E-0803 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,4-F | 0 |
E-0804 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,5-F | 0 |
E-0805 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,6-F | 0 |
E-0806 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,3-Me | 0 |
E-0807 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,4-Me | 0 |
E-0808 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,5-Me | 0 |
E-0809 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,6-Me | 0 |
E-0810 | H | H | H | H | H | 2-SCF<sub>3</sub>,3-F | 0 |
E-0811 | H | H | H | H | H | 2-SCF<sub>3</sub>,4-F | 0 |
E-0812 | H | H | H | H | H | 2-SCF<sub>3</sub>,5-F | 0 |
E-0813 | H | H | H | H | H | 2-SCF<sub>3</sub>,6-F | 0 |
E-0814 | H | H | H | H | H | 2-SCF<sub>3</sub>,3-Me | 0 |
E-0815 | H | H | H | H | H | 2-SCF<sub>3</sub>,4-Me | 0 |
E-0816 | H | H | H | H | H | 2-SCF<sub>3</sub>,5-Me | 0 |
E-0817 | H | H | H | H | H | 2-SCF<sub>3</sub>,6-Me | 0 |
E-0818 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,3-F | 0 |
E-0819 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,4-F | 0 |
E-0820 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,5-F | 0 |
E-0821 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,6-F | 0 |
E-0822 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,3-Me | 0 |
E-0823 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,4-Me | 0 |
E-0824 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,5-Me | 0 |
E-0825 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,6-Me | 0 |
E-0826 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-F | 0 |
E-0827 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-F | 0 |
E-0828 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 0 |
E-0829 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 0 |
E-0830 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-Me | 0 |
E-0831 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-Me | 0 |
E-0832 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 0 |
E-0833 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 0 |
E-0834 | H | H | H | H | H | 2-(环丙基硫基),3-F | 0 |
E-0835 | H | H | H | H | H | 2-(环丙基硫基),4-F | 0 |
E-0836 | H | H | H | H | H | 2-(环丙基硫基),5-F | 0 |
E-0837 | H | H | H | H | H | 2-(环丙基硫基),6-F | 0 |
E-0838 | H | H | H | H | H | 2-(环丙基硫基),3-Me | 0 |
E-0839 | H | H | H | H | H | 2-(环丙基硫基),4-Me | 0 |
E-0840 | H | H | H | H | H | 2-(环丙基硫基),5-Me | 0 |
E-0841 | H | H | H | H | H | 2-(环丙基硫基),6-Me | 0 |
E-0842 | H | H | H | H | H | 2-C(=O)Me,3-F | 0 |
E-0843 | H | H | H | H | H | 2-C(=O)Me,4-F | 0 |
E-0844 | H | H | H | H | H | 2-C(=O)Me,5-F | 0 |
E-0845 | H | H | H | H | H | 2-C(=O)Me,6-F | 0 |
E-0846 | H | H | H | H | H | 2-C(=O)Me,3-Me | 0 |
E-0847 | H | H | H | H | H | 2-C(=O)Me,4-Me | 0 |
E-0848 | H | H | H | H | H | 2-C(=O)Me,5-Me | 0 |
E-0849 | H | H | H | H | H | 2-C(=O)Me,6-Me | 0 |
E-0850 | H | H | H | H | H | 3-C(=O)Me,2-F | 0 |
[表273]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0851 | H | H | H | H | H | 3-C(=O)Me,4-F | 0 |
E-0852 | H | H | H | H | H | 3-C(=O)Me,5-F | 0 |
E-0853 | H | H | H | H | H | 3-C(=O)Me,6-F | 0 |
E-0854 | H | H | H | H | H | 3-C(=O)Me,2-Me | 0 |
E-0855 | H | H | H | H | H | 3-C(=O)Me,4-Me | 0 |
E-0856 | H | H | H | H | H | 3-C(=O)Me,5-Me | 0 |
E-0857 | H | H | H | H | H | 3-C(=O)Me,6-Me | 0 |
E-0858 | H | H | H | H | H | 2-C(=O)OMe,3-F | 0 |
E-0859 | H | H | H | H | H | 2-C(=O)OMe,4-F | 0 |
E-0860 | H | H | H | H | H | 2-C(=O)OMe,5-F | 0 |
E-0861 | H | H | H | H | H | 2-C(=O)OMe,6-F | 0 |
E-0862 | H | H | H | H | H | 2-C(=O)OMe,3-Me | 0 |
E-0863 | H | H | H | H | H | 2-C(=O)OMe,4-Me | 0 |
E-0864 | H | H | H | H | H | 2-C(=O)OMe,5-Me | 0 |
E-0865 | H | H | H | H | H | 2-C(=O)OMe,6-Me | 0 |
E-0866 | H | H | H | H | H | 2-C(=O)OEt,3-F | 0 |
E-0867 | H | H | H | H | H | 2-C(=O)OEt,4-F | 0 |
E-0868 | H | H | H | H | H | 2-C(=O)OEt,5-F | 0 |
E-0869 | H | H | H | H | H | 2-C(=O)OEt,6-F | 0 |
E-0870 | H | H | H | H | H | 2-C(=O)OEt,3-Me | 0 |
E-0871 | H | H | H | H | H | 2-C(=O)OEt,4-Me | 0 |
E-0872 | H | H | H | H | H | 2-C(=O)OEt,5-Me | 0 |
E-0873 | H | H | H | H | H | 2-C(=O)OEt,6-Me | 0 |
E-0874 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,3-F | 0 |
E-0875 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,4-F | 0 |
E-0876 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,5-F | 0 |
E-0877 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,6-F | 0 |
E-0878 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,3-Me | 0 |
E-0879 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,4-Me | 0 |
E-0880 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,5-Me | 0 |
E-0881 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,6-Me | 0 |
E-0882 | H | H | H | H | H | 2-C(=O)NHMe,3-F | 0 |
E-0883 | H | H | H | H | H | 2-C(=O)NHMe,4-F | 0 |
E-0884 | H | H | H | H | H | 2-C(=O)NHMe,5-F | 0 |
E-0885 | H | H | H | H | H | 2-C(=O)NHMe,6-F | 0 |
E-0886 | H | H | H | H | H | 2-C(=O)NHMe,3-Me | 0 |
E-0887 | H | H | H | H | H | 2-C(=O)NHMe,4-Me | 0 |
E-0888 | H | H | H | H | H | 2-C(=O)NHMe,5-Me | 0 |
E-0889 | H | H | H | H | H | 2-C(=O)NHMe,6-Me | 0 |
E-0890 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,3-F | 0 |
E-0891 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,4-F | 0 |
E-0892 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,5-F | 0 |
E-0893 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,6-F | 0 |
E-0894 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,3-Me | 0 |
E-0895 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,4-Me | 0 |
E-0896 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,5-Me | 0 |
E-0897 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,6-Me | 0 |
E-0898 | H | H | H | H | H | 2-CH<sub>2</sub>OH,3-F | 0 |
E-0899 | H | H | H | H | H | 2-CH<sub>2</sub>OH,4-F | 0 |
E-0900 | H | H | H | H | H | 2-CH<sub>2</sub>OH,5-F | 0 |
E-0901 | H | H | H | H | H | 2-CH<sub>2</sub>OH,6-F | 0 |
E-0902 | H | H | H | H | H | 2-CH<sub>2</sub>OH,3-Me | 0 |
E-0903 | H | H | H | H | H | 2-CH<sub>2</sub>OH,4-Me | 0 |
E-0904 | H | H | H | H | H | 2-CH<sub>2</sub>OH,5-Me | 0 |
E-0905 | H | H | H | H | H | 2-CH<sub>2</sub>OH,6-Me | 0 |
E-0906 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-F | 0 |
E-0907 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 0 |
[表274]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0908 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 0 |
E-0909 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 0 |
E-0910 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-Me | 0 |
E-0911 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 0 |
E-0912 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 0 |
E-0913 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 0 |
E-0914 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-F | 0 |
E-0915 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-F | 0 |
E-0916 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
E-0917 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
E-0918 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-Me | 0 |
E-0919 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-Me | 0 |
E-0920 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
E-0921 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
E-0922 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,3-F | 0 |
E-0923 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,4-F | 0 |
E-0924 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,5-F | 0 |
E-0925 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,6-F | 0 |
E-0926 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,3-Me | 0 |
E-0927 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,4-Me | 0 |
E-0928 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 0 |
E-0929 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 0 |
E-0930 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-F | 0 |
E-0931 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-F | 0 |
E-0932 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 0 |
E-0933 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 0 |
E-0934 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-Me | 0 |
E-0935 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-Me | 0 |
E-0936 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 0 |
E-0937 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 0 |
E-0938 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-F | 0 |
E-0939 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-F | 0 |
E-0940 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 0 |
E-0941 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 0 |
E-0942 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-Me | 0 |
E-0943 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-Me | 0 |
E-0944 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 0 |
E-0945 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 0 |
E-0946 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-F | 0 |
E-0947 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-F | 0 |
E-0948 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-F | 0 |
E-0949 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-F | 0 |
E-0950 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-Me | 0 |
E-0951 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-Me | 0 |
E-0952 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-Me | 0 |
E-0953 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-Me | 0 |
E-0954 | H | H | H | H | H | 2-(苯甲基氧基),3-F | 0 |
E-0955 | H | H | H | H | H | 2-(苯甲基氧基),4-F | 0 |
E-0956 | H | H | H | H | H | 2-(苯甲基氧基),5-F | 0 |
E-0957 | H | H | H | H | H | 2-(苯甲基氧基),6-F | 0 |
E-0958 | H | H | H | H | H | 2-(苯甲基氧基),3-Me | 0 |
E-0959 | H | H | H | H | H | 2-(苯甲基氧基),4-Me | 0 |
E-0960 | H | H | H | H | H | 2-(苯甲基氧基),5-Me | 0 |
E-0961 | H | H | H | H | H | 2-(苯甲基氧基),6-Me | 0 |
E-0962 | H | H | H | H | H | 2-NH<sub>2</sub>,3-F | 0 |
E-0963 | H | H | H | H | H | 2-NH<sub>2</sub>,4-F | 0 |
E-0964 | H | H | H | H | H | 2-NH<sub>2</sub>,5-F | 0 |
[表275]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-0965 | H | H | H | H | H | 2-NH<sub>2</sub>,6-F | 0 |
E-0966 | H | H | H | H | H | 2-NH<sub>2</sub>,3-Me | 0 |
E-0967 | H | H | H | H | H | 2-NH<sub>2</sub>,4-Me | 0 |
E-0968 | H | H | H | H | H | 2-NH<sub>2</sub>,5-Me | 0 |
E-0969 | H | H | H | H | H | 2-NH<sub>2</sub>,6-Me | 0 |
E-0970 | H | H | H | H | H | 2-NHMe,3-F | 0 |
E-0971 | H | H | H | H | H | 2-NHMe,4-F | 0 |
E-0972 | H | H | H | H | H | 2-NHMe,5-F | 0 |
E-0973 | H | H | H | H | H | 2-NHMe,6-F | 0 |
E-0974 | H | H | H | H | H | 2-NHMe,3-Me | 0 |
E-0975 | H | H | H | H | H | 2-NHMe,4-Me | 0 |
E-0976 | H | H | H | H | H | 2-NHMe,5-Me | 0 |
E-0977 | H | H | H | H | H | 2-NHMe,6-Me | 0 |
E-0978 | H | H | H | H | H | 2-NHEt,3-F | 0 |
E-0979 | H | H | H | H | H | 2-NHEt,4-F | 0 |
E-0980 | H | H | H | H | H | 2-NHEt,5-F | 0 |
E-0981 | H | H | H | H | H | 2-NHEt,6-F | 0 |
E-0982 | H | H | H | H | H | 2-NHEt,3-Me | 0 |
E-0983 | H | H | H | H | H | 2-NHEt,4-Me | 0 |
E-0984 | H | H | H | H | H | 2-NHEt,5-Me | 0 |
E-0985 | H | H | H | H | H | 2-NHEt,6-Me | 0 |
E-0986 | H | H | H | H | H | 2-NMe<sub>2</sub>,3-F | 0 |
E-0987 | H | H | H | H | H | 2-NMe<sub>2</sub>,4-F | 0 |
E-0988 | H | H | H | H | H | 2-NMe<sub>2</sub>,5-F | 0 |
E-0989 | H | H | H | H | H | 2-NMe<sub>2</sub>,6-F | 0 |
E-0990 | H | H | H | H | H | 2-NMe<sub>2</sub>,3-Me | 0 |
E-0991 | H | H | H | H | H | 2-NMe<sub>2</sub>,4-Me | 0 |
E-0992 | H | H | H | H | H | 2-NMe<sub>2</sub>,5-Me | 0 |
E-0993 | H | H | H | H | H | 2-NMe<sub>2</sub>,6-Me | 0 |
E-0994 | H | H | H | H | H | 2-NEt<sub>2</sub>,3-F | 0 |
E-0995 | H | H | H | H | H | 2-NEt<sub>2</sub>,4-F | 0 |
E-0996 | H | H | H | H | H | 2-NEt<sub>2</sub>,5-F | 0 |
E-0997 | H | H | H | H | H | 2-NEt<sub>2</sub>,6-F | 0 |
E-0998 | H | H | H | H | H | 2-NEt<sub>2</sub>,3-Me | 0 |
E-0999 | H | H | H | H | H | 2-NEt<sub>2</sub>,4-Me | 0 |
E-1000 | H | H | H | H | H | 2-NEt<sub>2</sub>,5-Me | 0 |
E-1001 | H | H | H | H | H | 2-NEt<sub>2</sub>,6-Me | 0 |
E-1002 | H | H | H | H | H | 2-CHO,3-F | 0 |
E-1003 | H | H | H | H | H | 2-CHO,4-F | 0 |
E-1004 | H | H | H | H | H | 2-CHO,5-F | 0 |
E-1005 | H | H | H | H | H | 2-CHO,6-F | 0 |
E-1006 | H | H | H | H | H | 2-CHO,3-Me | 0 |
E-1007 | H | H | H | H | H | 2-CHO,4-Me | 0 |
E-1008 | H | H | H | H | H | 2-CHO,5-Me | 0 |
E-1009 | H | H | H | H | H | 2-CHO,6-Me | 0 |
E-1010 | H | H | H | H | H | 2-C(=O)OH,3-F | 0 |
E-1011 | H | H | H | H | H | 2-C(=O)OH,4-F | 0 |
E-1012 | H | H | H | H | H | 2-C(=O)OH,5-F | 0 |
E-1013 | H | H | H | H | H | 2-C(=O)OH,6-F | 0 |
E-1014 | H | H | H | H | H | 2-C(=O)OH,3-Me | 0 |
E-1015 | H | H | H | H | H | 2-C(=O)OH,4-Me | 0 |
E-1016 | H | H | H | H | H | 2-C(=O)OH,5-Me | 0 |
E-1017 | H | H | H | H | H | 2-C(=O)OH,6-Me | 0 |
E-1018 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),3-F | 0 |
E-1019 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),4-F | 0 |
E-1020 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),5-F | 0 |
E-1021 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),6-F | 0 |
[表276]
[表277]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-1079 | H | H | H | H | H | 2-CN,4-OMe | 0 |
E-1080 | H | H | H | H | H | 2-CN,5-OMe | 0 |
E-1081 | H | H | H | H | H | 2-CN,6-OMe | 0 |
E-1082 | H | H | H | H | H | 3-CN,2-F | 0 |
E-1083 | H | H | H | H | H | 3-CN,4-F | 0 |
E-1084 | H | H | H | H | H | 3-CN,5-F | 0 |
E-1085 | H | H | H | H | H | 3-CN,6-F | 0 |
E-1086 | H | H | H | H | H | 3-CN,2-Cl | 0 |
E-1087 | H | H | H | H | H | 3-CN,4-Cl | 0 |
E-1088 | H | H | H | H | H | 3-CN,5-Cl | 0 |
E-1089 | H | H | H | H | H | 3-CN,6-Cl | 0 |
E-1090 | H | H | H | H | H | 3-CN,2-Me | 0 |
E-1091 | H | H | H | H | H | 3-CN,4-Me | 0 |
E-1092 | H | H | H | H | H | 3-CN,5-Me | 0 |
E-1093 | H | H | H | H | H | 3-CN,6-Me | 0 |
E-1094 | H | H | H | H | H | 3-CN,2-OMe | 0 |
E-1095 | H | H | H | H | H | 3-CN,4-OMe | 0 |
E-1096 | H | H | H | H | H | 3-CN,5-OMe | 0 |
E-1097 | H | H | H | H | H | 3-CN,6-OMe | 0 |
E-1098 | H | H | H | H | H | 4-CN,2-F | 0 |
E-1099 | H | H | H | H | H | 4-CN,3-F | 0 |
E-1100 | H | H | H | H | H | 4-CN,2-Cl | 0 |
E-1101 | H | H | H | H | H | 4-CN,3-Cl | 0 |
E-1102 | H | H | H | H | H | 4-CN,2-Me | 0 |
E-1103 | H | H | H | H | H | 4-CN,3-Me | 0 |
E-1104 | H | H | H | H | H | 4-CN,2-OMe | 0 |
E-1105 | H | H | H | H | H | 4-CN,3-OMe | 0 |
E-1106 | H | H | H | H | H | 2-NO<sub>2</sub>,3-F | 0 |
E-1107 | H | H | H | H | H | 2-NO<sub>2</sub>,4-F | 0 |
E-1108 | H | H | H | H | H | 2-NO<sub>2</sub>,5-F | 0 |
E-1109 | H | H | H | H | H | 2-NO<sub>2</sub>,6-F | 0 |
E-1110 | H | H | H | H | H | 2-NO<sub>2</sub>,3-Me | 0 |
E-1111 | H | H | H | H | H | 2-NO<sub>2</sub>,4-Me | 0 |
E-1112 | H | H | H | H | H | 2-NO<sub>2</sub>,5-Me | 0 |
E-1113 | H | H | H | H | H | 2-NO<sub>2</sub>,6-Me | 0 |
E-1114 | H | H | H | H | H | 2-Me,3,4-F<sub>2</sub> | 0 |
E-1115 | H | H | H | H | H | 2-Me,3,5-F<sub>2</sub> | 0 |
E-1116 | H | H | H | H | H | 2-Me,3,6-F<sub>2</sub> | 0 |
E-1117 | H | H | H | H | H | 2-Me,4,5-F<sub>2</sub> | 0 |
E-1118 | H | H | H | H | H | 2-OMe,3,4-F<sub>2</sub> | 0 |
E-1119 | H | H | H | H | H | 2-OMe,3,5-F<sub>2</sub> | 0 |
E-1120 | H | H | H | H | H | 2-OMe,3,6-F<sub>2</sub> | 0 |
E-1121 | H | H | H | H | H | 2-OMe,4,5-F<sub>2</sub> | 0 |
E-1122 | H | H | H | H | H | 2-(CH<sub>2</sub>)<sub>3</sub>-3 | 0 |
E-1123 | H | H | H | H | H | 2-(CH<sub>2</sub>)<sub>4</sub>-3 | 0 |
E-1124 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>)-3 | 0 |
E-1125 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-3 | 0 |
E-1126 | H | H | H | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>O)-3 | 0 |
E-1127 | H | H | H | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-3 | 0 |
E-1128 | H | H | H | H | H | 3-(CH<sub>2</sub>)<sub>3</sub>-4 | 0 |
E-1129 | H | H | H | H | H | 3-(CH<sub>2</sub>)<sub>4</sub>-4 | 0 |
E-1130 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>)-4 | 0 |
E-1131 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-4 | 0 |
E-1132 | H | H | H | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>O)-4 | 0 |
E-1133 | H | H | H | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-4 | 0 |
E-1134 | H | H | H | H | H | 2-(OCH<sub>2</sub>O)-3 | 0 |
E-1135 | H | H | H | H | H | 3-(OCH<sub>2</sub>O)-4 | 0 |
[表278]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-1136 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>O)-3 | 0 |
E-1137 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>O)-4 | 0 |
E-1138 | H | H | H | H | H | 2-(OCF<sub>2</sub>O)-3 | 0 |
E-1139 | H | H | H | H | H | 3-(OCF<sub>2</sub>O)-4 | 0 |
E-1140 | H | H | H | H | H | 2-Me,6-Et | 0 |
E-1141 | H | H | H | H | H | 2-CH<sub>2</sub>OTBS | 0 |
E-1142 | H | H | H | H | H | 2-环丙基,3-OMe | 0 |
E-1143 | H | H | H | H | H | 2-环丙基,4-OMe | 0 |
E-1144 | H | H | H | H | H | 2-环丙基,5-OMe | 0 |
E-1145 | H | H | H | H | H | 2-环丙基,6-OMe | 0 |
E-1146 | H | H | H | H | H | 2-Me,3-OMe,6-Me | 0 |
E-1147 | H | H | H | H | H | 2-Me,4-OMe,6-Me | 0 |
E-1148 | H | H | H | H | H | 2-OMe,3-Me,6-Me | 0 |
E-1149 | H | H | H | H | H | 2-OMe,5-Me,6-Me | 0 |
E-1150 | H | H | H | H | H | 2-OMe,3-F,6-Me | 0 |
E-1151 | H | H | H | H | H | 2-OMe,5-F,6-Me | 0 |
E-1152 | H | H | H | H | H | 2-OMe,5-Me,6-F | 0 |
E-1153 | H | H | H | H | H | 2-Cl,3-Me,6-F | 0 |
E-1154 | H | H | H | H | H | 2-Cl,5-Me,6-F | 0 |
E-1155 | H | H | H | H | H | 2-Cl,3-OMe,6-F | 0 |
E-1156 | H | H | H | H | H | 2-Cl,5-OMe,6-F | 0 |
E-1157 | H | H | H | H | H | 2-Me,5-Et | 0 |
E-1158 | H | H | H | H | H | 2,6-Et<sub>2</sub> | 0 |
E-1159 | H | H | H | H | H | 2-Et,6-F | 0 |
E-1160 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 0 |
E-1161 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 0 |
E-1162 | H | H | H | H | H | 2-OMe,5-CH=NOMe | 0 |
E-1163 | H | H | H | H | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 0 |
E-1164 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-CF<sub>3</sub> | 0 |
E-1165 | H | H | F | H | H | 2-Me | 0 |
E-1166 | H | H | F | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-OMe | 0 |
E-1167 | H | H | F | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-OMe | 0 |
E-1168 | H | H | F | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-CN | 0 |
E-1169 | H | H | F | H | H | 2-OEt,6-CN | 0 |
E-1170 | H | H | F | H | H | 2-OEt,6-OMe | 0 |
E-1171 | H | H | F | H | H | 2,6-OEt<sub>2</sub> | 0 |
E-1172 | H | H | F | H | H | 2-CN,6-环丙基 | 0 |
E-1173 | H | H | F | H | H | 2-MeO,3-Me,6-MeO | 0 |
E-1174 | H | H | F | H | H | 2-MeO,4-Me,6-MeO | 0 |
E-1175 | H | H | F | H | H | 2-MeO,3-F,6-MeO | 0 |
E-1176 | H | H | F | H | H | 2-MeO,4-F,6-MeO | 0 |
E-1177 | H | H | F | H | H | 2-Et,6-OEt | 0 |
E-1178 | H | H | F | H | H | 2-环丙基,6-OEt | 0 |
E-1179 | H | H | F | H | H | 2,6-SMe<sub>2</sub> | 0 |
E-1180 | H | H | F | H | H | 2-NO<sub>2</sub>,6-OMe | 0 |
E-1181 | H | H | F | H | H | 2-NO<sub>2</sub>,6-CN | 0 |
E-1182 | H | H | F | H | H | 2-Cl,6-NO<sub>2</sub> | 0 |
E-1183 | H | H | F | H | H | 2-Cl,6-SMe | 0 |
E-1184 | H | H | F | H | H | 2-Cl,6-Et | 0 |
E-1185 | H | H | F | H | H | 2-CN,6-SMe | 0 |
E-1186 | H | H | F | H | H | 2,6-CN<sub>2</sub> | 0 |
E-1187 | H | H | F | H | H | 2-OMe,6-OCF<sub>3</sub> | 0 |
E-1188 | H | H | F | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-OMe | 0 |
E-1189 | H | H | F | H | H | 2-OCHF<sub>2</sub>,6-Ome | 0 |
E-1190 | H | H | F | H | H | 2-Cl,6-CH<sub>2</sub>SCH<sub>3</sub> | 0 |
E-1191 | H | H | F | H | H | 2-CN,6-Et | 0 |
[表279]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-1192 | H | H | H | H | H | 2-Et,6-OEt | 0 |
E-1193 | H | H | H | H | H | 2-(吡啶-2-基) | 0 |
E-1193 | H | H | H | H | H | 3-(吡啶-2-基) | 0 |
E-1194 | H | H | H | H | H | 4-(吡啶-2-基) | 0 |
E-1195 | H | H | H | H | H | 2-(嘧啶-2-基) | 0 |
E-1196 | H | H | H | H | H | 3-(嘧啶-2-基) | 0 |
E-1197 | H | H | H | H | H | 4-(嘧啶-2-基) | 0 |
E-1198 | H | H | H | H | H | 2-(吡嗪-2-基) | 0 |
E-1199 | H | H | H | H | H | 3-(吡嗪-2-基) | 0 |
E-1200 | H | H | H | H | H | 4-(吡嗪-2-基) | 0 |
E-1201 | H | H | H | H | H | 2-(1,3,5-三嗪-2-基) | 0 |
E-1202 | H | H | H | H | H | 3-(1,3,5-三嗪-2-基) | 0 |
E-1203 | H | H | H | H | H | 4-(1,3,5-三嗪-2-基) | 0 |
E-1204 | H | H | H | H | H | 2-(1,2,4-三嗪-3-基) | 0 |
E-1205 | H | H | H | H | H | 3-(1,2,4-三嗪-3-基) | 0 |
E-1206 | H | H | H | H | H | 4-(1,2,4-三嗪-3-基) | 0 |
E-1207 | H | H | H | H | H | 2-(1,2,4-三嗪-6-基) | 0 |
E-1208 | H | H | H | H | H | 3-(1,2,4-三嗪-6-基) | 0 |
E-1209 | H | H | H | H | H | 4-(1,2,4-三嗪-6-基) | 0 |
E-1210 | H | H | H | H | H | 2-(1H-吡唑-1-基) | 0 |
E-1211 | H | H | H | H | H | 3-(1H-吡唑-1-基) | 0 |
E-1212 | H | H | H | H | H | 4-(1H-吡唑-1-基) | 0 |
[表280]
[表281]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5053 | H | H | H | H | H | 2-CF<sub>2</sub>Cl | 1 |
E-5054 | H | H | H | H | H | 3-CF<sub>2</sub>Cl | 1 |
E-5055 | H | H | H | H | H | 4-CF<sub>2</sub>Cl | 1 |
E-5056 | H | H | H | H | H | 2-CF(CF<sub>3</sub>)<sub>2</sub> | 1 |
E-5057 | H | H | H | H | H | 3-CF(CF<sub>3</sub>)<sub>2</sub> | 1 |
E-5058 | H | H | H | H | H | 4-CF(CF<sub>3</sub>)<sub>2</sub> | 1 |
E-5059 | H | H | H | H | H | 2-环丙基 | 1 |
E-5060 | H | H | H | H | H | 3-环丙基 | 1 |
E-5061 | H | H | H | H | H | 4-环丙基 | 1 |
E-5062 | H | H | H | H | H | 2-环丁基 | 1 |
E-5063 | H | H | H | H | H | 3-环丁基 | 1 |
E-5064 | H | H | H | H | H | 4-环丁基 | 1 |
E-5065 | H | H | H | H | H | 2-环戊基 | 1 |
E-5066 | H | H | H | H | H | 3-环戊基 | 1 |
E-5067 | H | H | H | H | H | 4-环戊基 | 1 |
E-5068 | H | H | H | H | H | 2-(环丙基甲基) | 1 |
E-5069 | H | H | H | H | H | 3-(环丙基甲基) | 1 |
E-5070 | H | H | H | H | H | 4-(环丙基甲基) | 1 |
E-5071 | H | H | H | H | H | 2-(环丁基甲基) | 1 |
E-5072 | H | H | H | H | H | 3-(环丁基甲基) | 1 |
E-5073 | H | H | H | H | H | 4-(环丁基甲基) | 1 |
E-5074 | H | H | H | H | H | 2-(环戊基甲基) | 1 |
E-5075 | H | H | H | H | H | 3-(环戊基甲基) | 1 |
E-5076 | H | H | H | H | H | 4-(环戊基甲基) | 1 |
E-5077 | H | H | H | H | H | 2-(环丙基乙基) | 1 |
E-5078 | H | H | H | H | H | 3-(环丙基乙基) | 1 |
E-5079 | H | H | H | H | H | 4-(环丙基乙基) | 1 |
E-5080 | H | H | H | H | H | 2-(2,2-二氟环丙基) | 1 |
E-5081 | H | H | H | H | H | 3-(2,2-二氟环丙基) | 1 |
E-5082 | H | H | H | H | H | 4-(2,2-二氟环丙基) | 1 |
E-5083 | H | H | H | H | H | 2-(2,2-二氯环丙基) | 1 |
E-5084 | H | H | H | H | H | 3-(2,2-二氯环丙基) | 1 |
E-5085 | H | H | H | H | H | 4-(2,2-二氯环丙基) | 1 |
E-5086 | H | H | H | H | H | 2-乙烯基 | 1 |
E-5087 | H | H | H | H | H | 3-乙烯基 | 1 |
E-5088 | H | H | H | H | H | 4-乙烯基 | 1 |
E-5089 | H | H | H | H | H | 2-烯丙基 | 1 |
E-5090 | H | H | H | H | H | 3-烯丙基 | 1 |
E-5091 | H | H | H | H | H | 4-烯丙基 | 1 |
E-5092 | H | H | H | H | H | 2-(丙-1-烯-1-基) | 1 |
E-5093 | H | H | H | H | H | 3-(丙-1-烯-1-基) | 1 |
E-5094 | H | H | H | H | H | 4-(丙-1-烯-1-基) | 1 |
E-5095 | H | H | H | H | H | 2-(三氟乙烯基) | 1 |
E-5096 | H | H | H | H | H | 3-(三氟乙烯基) | 1 |
E-5097 | H | H | H | H | H | 4-(三氟乙烯基) | 1 |
E-5098 | H | H | H | H | H | 2-(2,2-二氯乙烯基) | 1 |
E-5099 | H | H | H | H | H | 3-(2,2-二氯乙烯基) | 1 |
E-5100 | H | H | H | H | H | 4-(2,2-二氯乙烯基) | 1 |
E-5101 | H | H | H | H | H | 2-乙炔基 | 1 |
E-5102 | H | H | H | H | H | 3-乙炔基 | 1 |
E-5103 | H | H | H | H | H | 4-乙炔基 | 1 |
E-5104 | H | H | H | H | H | 2-(1-丙炔-1-基) | 1 |
E-5105 | H | H | H | H | H | 3-(1-丙炔-1-基) | 1 |
E-5106 | H | H | H | H | H | 4-(1-丙炔-1-基) | 1 |
E-5107 | H | H | H | H | H | 2-(2-丙炔-1-基) | 1 |
E-5108 | H | H | H | H | H | 3-(2-丙炔-1-基) | 1 |
E-5109 | H | H | H | H | H | 4-(2-丙炔-1-基) | 1 |
[表282]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5110 | H | H | H | H | H | 2-(2-环丙基乙炔基) | 1 |
E-5111 | H | H | H | H | H | 3-(2-环丙基乙炔基) | 1 |
E-5112 | H | H | H | H | H | 4-(2-环丙基乙炔基) | 1 |
E-5113 | H | H | H | H | H | 2-(2-氯乙炔基) | 1 |
E-5114 | H | H | H | H | H | 3-(2-氯乙炔基) | 1 |
E-5115 | H | H | H | H | H | 4-(2-氯乙炔基) | 1 |
E-5116 | H | H | H | H | H | 2-(2-溴乙炔基) | 1 |
E-5117 | H | H | H | H | H | 3-(2-溴乙炔基) | 1 |
E-5118 | H | H | H | H | H | 4-(2-溴乙炔基) | 1 |
E-5119 | H | H | H | H | H | 2-OMe | 1 |
E-5120 | H | H | H | H | H | 3-OMe | 1 |
E-5121 | H | H | H | H | H | 4-OMe | 1 |
E-5122 | H | H | H | H | H | 2-OEt | 1 |
E-5123 | H | H | H | H | H | 3-OEt | 1 |
E-5124 | H | H | H | H | H | 4-OEt | 1 |
E-5125 | H | H | H | H | H | 2-OPr | 1 |
E-5126 | H | H | H | H | H | 3-OPr | 1 |
E-5127 | H | H | H | H | H | 4-OPr | 1 |
E-5128 | H | H | H | H | H | 2-O(i-Pr) | 1 |
E-5129 | H | H | H | H | H | 3-O(i-Pr) | 1 |
E-5130 | H | H | H | H | H | 4-O(i-Pr) | 1 |
E-5131 | H | H | H | H | H | 2-OBu | 1 |
E-5132 | H | H | H | H | H | 3-OBu | 1 |
E-5133 | H | H | H | H | H | 4-OBu | 1 |
E-5134 | H | H | H | H | H | 2-O(s-Bu) | 1 |
E-5135 | H | H | H | H | H | 3-O(s-Bu) | 1 |
E-5136 | H | H | H | H | H | 4-O(s-Bu) | 1 |
E-5137 | H | H | H | H | H | 2-O(i-Bu) | 1 |
E-5138 | H | H | H | H | H | 3-O(i-Bu) | 1 |
E-5139 | H | H | H | H | H | 4-O(i-Bu) | 1 |
E-5140 | H | H | H | H | H | 2-O(t-Bu) | 1 |
E-5141 | H | H | H | H | H | 3-O(t-Bu) | 1 |
E-5142 | H | H | H | H | H | 4-O(t-Bu) | 1 |
E-5143 | H | H | H | H | H | 2-OCF<sub>3</sub> | 1 |
E-5144 | H | H | H | H | H | 3-OCF<sub>3</sub> | 1 |
E-5145 | H | H | H | H | H | 4-OCF<sub>3</sub> | 1 |
E-5146 | H | H | H | H | H | 2-OCHF<sub>2</sub> | 1 |
E-5147 | H | H | H | H | H | 3-OCHF<sub>2</sub> | 1 |
E-5148 | H | H | H | H | H | 4-OCHF<sub>2</sub> | 1 |
E-5149 | H | H | H | H | H | 2-OCH<sub>2</sub>CF<sub>3</sub> | 1 |
E-5150 | H | H | H | H | H | 3-OCH<sub>2</sub>CF<sub>3</sub> | 1 |
E-5151 | H | H | H | H | H | 4-OCH<sub>2</sub>CF<sub>3</sub> | 1 |
E-5152 | H | H | H | H | H | 2-(环丙基氧基) | 1 |
E-5153 | H | H | H | H | H | 3-(环丙基氧基) | 1 |
E-5154 | H | H | H | H | H | 4-(环丙基氧基) | 1 |
E-5155 | H | H | H | H | H | 2-(环丁基氧基) | 1 |
E-5156 | H | H | H | H | H | 3-(环丁基氧基) | 1 |
E-5157 | H | H | H | H | H | 4-(环丁基氧基) | 1 |
E-5158 | H | H | H | H | H | 2-(环戊基氧基) | 1 |
E-5159 | H | H | H | H | H | 3-(环戊基氧基) | 1 |
E-5160 | H | H | H | H | H | 4-(环戊基氧基) | 1 |
E-5161 | H | H | H | H | H | 2-((2,2-二氯环丙基)氧基) | 1 |
E-5162 | H | H | H | H | H | 3-((2,2-二氯环丙基)氧基) | 1 |
E-5163 | H | H | H | H | H | 4-((2,2-二氯环丙基)氧基) | 1 |
E-5164 | H | H | H | H | H | 2-(环丙基甲氧基) | 1 |
E-5165 | H | H | H | H | H | 3-(环丙基甲氧基) | 1 |
E-5166 | H | H | H | H | H | 4-(环丙基甲氧基) | 1 |
[表283]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5167 | H | H | H | H | H | 2-((2,2-二氟环丙基)甲氧基) | 1 |
E-5168 | H | H | H | H | H | 3-((2,2-二氟环丙基)甲氧基) | 1 |
E-5169 | H | H | H | H | H | 4-((2,2-二氟环丙基)甲氧基) | 1 |
E-5170 | H | H | H | H | H | 2-(环氧乙烷-2-基) | 1 |
E-5171 | H | H | H | H | H | 3-(环氧乙烷-2-基) | 1 |
E-5172 | H | H | H | H | H | 4-(环氧乙烷-2-基) | 1 |
E-5173 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基) | 1 |
E-5174 | H | H | H | H | H | 3-(环氧乙烷-2-基甲基) | 1 |
E-5175 | H | H | H | H | H | 4-(环氧乙烷-2-基甲基) | 1 |
E-5176 | H | H | H | H | H | 2-SMe | 1 |
E-5177 | H | H | H | H | H | 3-SMe | 1 |
E-5178 | H | H | H | H | H | 4-SMe | 1 |
E-5179 | H | H | H | H | H | 2-SEt | 1 |
E-5180 | H | H | H | H | H | 3-SEt | 1 |
E-5181 | H | H | H | H | H | 4-SEt | 1 |
E-5182 | H | H | H | H | H | 2-S(=O)Me | 1 |
E-5183 | H | H | H | H | H | 3-S(=O)Me | 1 |
E-5184 | H | H | H | H | H | 4-S(=O)Me | 1 |
E-5185 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me | 1 |
E-5186 | H | H | H | H | H | 3-S(=O)<sub>2</sub>Me | 1 |
E-5187 | H | H | H | H | H | 4-S(=O)<sub>2</sub>Me | 1 |
E-5188 | H | H | H | H | H | 2-SCF<sub>3</sub> | 1 |
E-5189 | H | H | H | H | H | 3-SCF<sub>3</sub> | 1 |
E-5190 | H | H | H | H | H | 4-SCF<sub>3</sub> | 1 |
E-5191 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub> | 1 |
E-5192 | H | H | H | H | H | 3-S(=O)CF<sub>3</sub> | 1 |
E-5193 | H | H | H | H | H | 4-S(=O)CF<sub>3</sub> | 1 |
E-5194 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
E-5195 | H | H | H | H | H | 3-S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
E-5196 | H | H | H | H | H | 4-S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
E-5197 | H | H | H | H | H | 2-SCF(CF<sub>3</sub>)<sub>2</sub> | 1 |
E-5198 | H | H | H | H | H | 3-SCF(CF<sub>3</sub>)<sub>2</sub> | 1 |
E-5199 | H | H | H | H | H | 4-SCF(CF<sub>3</sub>)<sub>2</sub> | 1 |
E-5200 | H | H | H | H | H | 2-(环丙基硫基) | 1 |
E-5201 | H | H | H | H | H | 3-(环丙基硫基) | 1 |
E-5202 | H | H | H | H | H | 4-(环丙基硫基) | 1 |
E-5203 | H | H | H | H | H | 2-(环丙基亚磺酰基) | 1 |
E-5204 | H | H | H | H | H | 3-(环丙基亚磺酰基) | 1 |
E-5205 | H | H | H | H | H | 4-(环丙基亚磺酰基) | 1 |
E-5206 | H | H | H | H | H | 2-(环丙基磺酰基) | 1 |
E-5207 | H | H | H | H | H | 3-(环丙基磺酰基) | 1 |
E-5208 | H | H | H | H | H | 4-(环丙基磺酰基) | 1 |
E-5209 | H | H | H | H | H | 2-((环丙基甲基)硫基) | 1 |
E-5210 | H | H | H | H | H | 3-((环丙基甲基)硫基) | 1 |
E-5211 | H | H | H | H | H | 4-((环丙基甲基)硫基) | 1 |
E-5212 | H | H | H | H | H | 2-((环丙基甲基)亚磺酰基) | 1 |
E-5213 | H | H | H | H | H | 3-((环丙基甲基)亚磺酰基) | 1 |
E-5214 | H | H | H | H | H | 4-((环丙基甲基)亚磺酰基) | 1 |
E-5215 | H | H | H | H | H | 2-((环丙基甲基)磺酰基) | 1 |
E-5216 | H | H | H | H | H | 3-((环丙基甲基)磺酰基) | 1 |
E-5217 | H | H | H | H | H | 4-((环丙基甲基)磺酰基) | 1 |
E-5218 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)硫基) | 1 |
E-5219 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)硫基) | 1 |
E-5220 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)硫基) | 1 |
E-5221 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)亚磺酰基) | 1 |
E-5222 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)亚磺酰基) | 1 |
E-5223 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)亚磺酰基) | 1 |
[表284]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5224 | H | H | H | H | H | 2-(((2,2-二氟环丙基)甲基)磺酰基) | 1 |
E-5225 | H | H | H | H | H | 3-(((2,2-二氟环丙基)甲基)磺酰基) | 1 |
E-5226 | H | H | H | H | H | 4-(((2,2-二氟环丙基)甲基)磺酰基) | 1 |
E-5227 | H | H | H | H | H | 2-C(=O)Me | 1 |
E-5228 | H | H | H | H | H | 3-C(=O)Me | 1 |
E-5229 | H | H | H | H | H | 4-C(=O)Me | 1 |
E-5230 | H | H | H | H | H | 2-C(=O)Et | 1 |
E-5231 | H | H | H | H | H | 3-C(=O)Et | 1 |
E-5232 | H | H | H | H | H | 4-C(=O)Et | 1 |
E-5233 | H | H | H | H | H | 2-C(=O)CF<sub>3</sub> | 1 |
E-5234 | H | H | H | H | H | 3-C(=O)CF<sub>3</sub> | 1 |
E-5235 | H | H | H | H | H | 4-C(=O)CF<sub>3</sub> | 1 |
E-5236 | H | H | H | H | H | 2-C(=O)OMe | 1 |
E-5237 | H | H | H | H | H | 3-C(=O)OMe | 1 |
E-5238 | H | H | H | H | H | 4-C(=O)OMe | 1 |
E-5239 | H | H | H | H | H | 2-C(=O)OEt | 1 |
E-5240 | H | H | H | H | H | 3-C(=O)OEt | 1 |
E-5241 | H | H | H | H | H | 4-C(=O)OEt | 1 |
E-5242 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub> | 1 |
E-5243 | H | H | H | H | H | 3-C(=O)NH<sub>2</sub> | 1 |
E-5244 | H | H | H | H | H | 4-C(=O)NH<sub>2</sub> | 1 |
E-5245 | H | H | H | H | H | 2-C(=O)NHMe | 1 |
E-5246 | H | H | H | H | H | 3-C(=O)NHMe | 1 |
E-5247 | H | H | H | H | H | 4-C(=O)NHMe | 1 |
E-5248 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub> | 1 |
E-5249 | H | H | H | H | H | 3-C(=O)NMe<sub>2</sub> | 1 |
E-5250 | H | H | H | H | H | 4-C(=O)NMe<sub>2</sub> | 1 |
E-5251 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 1 |
E-5252 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 1 |
E-5253 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)CH<sub>3</sub> | 1 |
E-5254 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 1 |
E-5255 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 1 |
E-5256 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)CF<sub>3</sub> | 1 |
E-5257 | H | H | H | H | H | 2-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 1 |
E-5258 | H | H | H | H | H | 3-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 1 |
E-5259 | H | H | H | H | H | 4-CH<sub>2</sub>C(=O)OCH<sub>3</sub> | 1 |
E-5260 | H | H | H | H | H | 2-CH<sub>2</sub>OH | 1 |
E-5261 | H | H | H | H | H | 3-CH<sub>2</sub>OH | 1 |
E-5262 | H | H | H | H | H | 4-CH<sub>2</sub>OH | 1 |
E-5263 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub> | 1 |
E-5264 | H | H | H | H | H | 3-CH<sub>2</sub>OCH<sub>3</sub> | 1 |
E-5265 | H | H | H | H | H | 4-CH<sub>2</sub>OCH<sub>3</sub> | 1 |
E-5266 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 1 |
E-5267 | H | H | H | H | H | 3-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 1 |
E-5268 | H | H | H | H | H | 4-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub> | 1 |
E-5269 | H | H | H | H | H | 2-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 1 |
E-5270 | H | H | H | H | H | 3-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 1 |
E-5271 | H | H | H | H | H | 4-CH(CH<sub>3</sub>)OCH<sub>3</sub> | 1 |
E-5272 | H | H | H | H | H | 2-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 1 |
E-5273 | H | H | H | H | H | 3-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 1 |
E-5274 | H | H | H | H | H | 4-CH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub> | 1 |
E-5275 | H | H | H | H | H | 2-CH<sub>2</sub>OCF<sub>3</sub> | 1 |
E-5276 | H | H | H | H | H | 3-CH<sub>2</sub>OCF<sub>3</sub> | 1 |
E-5277 | H | H | H | H | H | 4-CH<sub>2</sub>OCF<sub>3</sub> | 1 |
E-5278 | H | H | H | H | H | 2-CF<sub>2</sub>OCH<sub>3</sub> | 1 |
E-5279 | H | H | H | H | H | 3-CF<sub>2</sub>OCH<sub>3</sub> | 1 |
E-5280 | H | H | H | H | H | 4-CF<sub>2</sub>OCH<sub>3</sub> | 1 |
[表285]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5281 | H | H | H | H | H | 2-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 1 |
E-5282 | H | H | H | H | H | 3-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 1 |
E-5283 | H | H | H | H | H | 4-CF<sub>2</sub>CF<sub>2</sub>OCF<sub>3</sub> | 1 |
E-5284 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub> | 1 |
E-5285 | H | H | H | H | H | 3-OC(=O)CH<sub>3</sub> | 1 |
E-5286 | H | H | H | H | H | 4-OC(=O)CH<sub>3</sub> | 1 |
E-5287 | H | H | H | H | H | 2-OC(=O)CF<sub>3</sub> | 1 |
E-5288 | H | H | H | H | H | 3-OC(=O)CF<sub>3</sub> | 1 |
E-5289 | H | H | H | H | H | 4-OC(=O)CF<sub>3</sub> | 1 |
E-5290 | H | H | H | H | H | 2-OC(=O)NH<sub>2</sub> | 1 |
E-5291 | H | H | H | H | H | 3-OC(=O)NH<sub>2</sub> | 1 |
E-5292 | H | H | H | H | H | 4-OC(=O)NH<sub>2</sub> | 1 |
E-5293 | H | H | H | H | H | 2-OC(=O)NHCH<sub>3</sub> | 1 |
E-5294 | H | H | H | H | H | 3-OC(=O)NHCH<sub>3</sub> | 1 |
E-5295 | H | H | H | H | H | 4-OC(=O)NHCH<sub>3</sub> | 1 |
E-5296 | H | H | H | H | H | 2-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
E-5297 | H | H | H | H | H | 3-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
E-5298 | H | H | H | H | H | 4-OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
E-5299 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 1 |
E-5300 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 1 |
E-5301 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)NH<sub>2</sub> | 1 |
E-5302 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 1 |
E-5303 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 1 |
E-5304 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)NHCH<sub>3</sub> | 1 |
E-5305 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
E-5306 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
E-5307 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)N(CH<sub>3</sub>)<sub>2</sub> | 1 |
E-5308 | H | H | H | H | H | 2-OC(=O)OCH<sub>3</sub> | 1 |
E-5309 | H | H | H | H | H | 3-OC(=O)OCH<sub>3</sub> | 1 |
E-5310 | H | H | H | H | H | 4-OC(=O)OCH<sub>3</sub> | 1 |
E-5311 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 1 |
E-5312 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 1 |
E-5313 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)OCH<sub>3</sub> | 1 |
E-5314 | H | H | H | H | H | 2-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 1 |
E-5315 | H | H | H | H | H | 3-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 1 |
E-5316 | H | H | H | H | H | 4-CH<sub>2</sub>OC(=O)CH<sub>3</sub> | 1 |
E-5317 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
E-5318 | H | H | H | H | H | 3-OS(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
E-5319 | H | H | H | H | H | 4-OS(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
E-5320 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
E-5321 | H | H | H | H | H | 3-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
E-5322 | H | H | H | H | H | 4-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
E-5323 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 1 |
E-5324 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 1 |
E-5325 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)CH<sub>3</sub> | 1 |
E-5326 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
E-5327 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
E-5328 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CH<sub>3</sub> | 1 |
E-5329 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub> | 1 |
E-5330 | H | H | H | H | H | 3-CH<sub>2</sub>SCF<sub>3</sub> | 1 |
E-5331 | H | H | H | H | H | 4-CH<sub>2</sub>SCF<sub>3</sub> | 1 |
E-5332 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 1 |
E-5333 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 1 |
E-5334 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)CF<sub>3</sub> | 1 |
E-5335 | H | H | H | H | H | 2-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
E-5336 | H | H | H | H | H | 3-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
E-5337 | H | H | H | H | H | 4-CH<sub>2</sub>S(=O)<sub>2</sub>CF<sub>3</sub> | 1 |
[表286]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5338 | H | H | H | H | H | 2-苯基 | 1 |
E-5339 | H | H | H | H | H | 3-苯基 | 1 |
E-5340 | H | H | H | H | H | 4-苯基 | 1 |
E-5341 | H | H | H | H | H | 2-(苯氧基) | 1 |
E-5342 | H | H | H | H | H | 3-(苯氧基) | 1 |
E-5343 | H | H | H | H | H | 4-(苯氧基) | 1 |
E-5344 | H | H | H | H | H | 2-苯甲基 | 1 |
E-5345 | H | H | H | H | H | 3-苯甲基 | 1 |
E-5346 | H | H | H | H | H | 4-苯甲基 | 1 |
E-5347 | H | H | H | H | H | 2-(苯甲基氧基) | 1 |
E-5348 | H | H | H | H | H | 3-(苯甲基氧基) | 1 |
E-5349 | H | H | H | H | H | 4-(苯甲基氧基) | 1 |
E-5350 | H | H | H | H | H | 2-((2-氟苯甲基)氧基) | 1 |
E-5351 | H | H | H | H | H | 3-((2-氟苯甲基)氧基) | 1 |
E-5352 | H | H | H | H | H | 4-((2-氟苯甲基)氧基) | 1 |
E-5353 | H | H | H | H | H | 2-((3-氟苯甲基)氧基) | 1 |
E-5354 | H | H | H | H | H | 3-((3-氟苯甲基)氧基) | 1 |
E-5355 | H | H | H | H | H | 4-((3-氟苯甲基)氧基) | 1 |
E-5356 | H | H | H | H | H | 2-((4-氟苯甲基)氧基) | 1 |
E-5357 | H | H | H | H | H | 3-((4-氟苯甲基)氧基) | 1 |
E-5358 | H | H | H | H | H | 4-((4-氟苯甲基)氧基) | 1 |
E-5359 | H | H | H | H | H | 2-((2-氯苯甲基)氧基) | 1 |
E-5360 | H | H | H | H | H | 3-((2-氯苯甲基)氧基) | 1 |
E-5361 | H | H | H | H | H | 4-((2-氯苯甲基)氧基) | 1 |
E-5362 | H | H | H | H | H | 2-((3-氯苯甲基)氧基) | 1 |
E-5363 | H | H | H | H | H | 3-((3-氯苯甲基)氧基) | 1 |
E-5364 | H | H | H | H | H | 4-((3-氯苯甲基)氧基) | 1 |
E-5365 | H | H | H | H | H | 2-((4-氯苯甲基)氧基) | 1 |
E-5366 | H | H | H | H | H | 3-((4-氯苯甲基)氧基) | 1 |
E-5367 | H | H | H | H | H | 4-((4-氯苯甲基)氧基) | 1 |
E-5368 | H | H | H | H | H | 2-((2-甲基苯甲基)氧基) | 1 |
E-5369 | H | H | H | H | H | 3-((2-甲基苯甲基)氧基) | 1 |
E-5370 | H | H | H | H | H | 4-((2-甲基苯甲基)氧基) | 1 |
E-5371 | H | H | H | H | H | 2-((3-甲基苯甲基)氧基) | 1 |
E-5372 | H | H | H | H | H | 3-((3-甲基苯甲基)氧基) | 1 |
E-5373 | H | H | H | H | H | 4-((3-甲基苯甲基)氧基) | 1 |
E-5374 | H | H | H | H | H | 2-((4-甲基苯甲基)氧基) | 1 |
E-5375 | H | H | H | H | H | 3-((4-甲基苯甲基)氧基) | 1 |
E-5376 | H | H | H | H | H | 4-((4-甲基苯甲基)氧基) | 1 |
E-5377 | H | H | H | H | H | 2-((2-(三氟甲基)苯甲基)氧基) | 1 |
E-5378 | H | H | H | H | H | 3-((2-(三氟甲基)苯甲基)氧基) | 1 |
E-5379 | H | H | H | H | H | 4-((2-(三氟甲基)苯甲基)氧基) | 1 |
E-5380 | H | H | H | H | H | 2-((3-(三氟甲基)苯甲基)氧基) | 1 |
E-5381 | H | H | H | H | H | 3-((3-(三氟甲基)苯甲基)氧基) | 1 |
E-5382 | H | H | H | H | H | 4-((3-(三氟甲基)苯甲基)氧基) | 1 |
E-5383 | H | H | H | H | H | 2-((4-(三氟甲基)苯甲基)氧基) | 1 |
E-5384 | H | H | H | H | H | 3-((4-(三氟甲基)苯甲基)氧基) | 1 |
E-5385 | H | H | H | H | H | 4-((4-(三氟甲基)苯甲基)氧基) | 1 |
E-5386 | H | H | H | H | H | 2-((2-甲氧基苯甲基)氧基) | 1 |
E-5387 | H | H | H | H | H | 3-((2-甲氧基苯甲基)氧基) | 1 |
E-5388 | H | H | H | H | H | 4-((2-甲氧基苯甲基)氧基) | 1 |
E-5389 | H | H | H | H | H | 2-((3-甲氧基苯甲基)氧基) | 1 |
E-5390 | H | H | H | H | H | 3-((3-甲氧基苯甲基)氧基) | 1 |
E-5391 | H | H | H | H | H | 4-((3-甲氧基苯甲基)氧基) | 1 |
E-5392 | H | H | H | H | H | 2-((4-甲氧基苯甲基)氧基) | 1 |
E-5393 | H | H | H | H | H | 3-((4-甲氧基苯甲基)氧基) | 1 |
E-5394 | H | H | H | H | H | 4-((4-甲氧基苯甲基)氧基) | 1 |
[表287]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5395 | H | H | H | H | H | 2-((2-(三氟甲氧基)苯甲基)氧基) | 1 |
E-5396 | H | H | H | H | H | 3-((2-(三氟甲氧基)苯甲基)氧基) | 1 |
E-5397 | H | H | H | H | H | 4-((2-(三氟甲氧基)苯甲基)氧基) | 1 |
E-5398 | H | H | H | H | H | 2-((3-(三氟甲氧基)苯甲基)氧基) | 1 |
E-5399 | H | H | H | H | H | 3-((3-(三氟甲氧基)苯甲基)氧基) | 1 |
E-5400 | H | H | H | H | H | 4-((3-(三氟甲氧基)苯甲基)氧基) | 1 |
E-5401 | H | H | H | H | H | 2-((4-(三氟甲氧基)苯甲基)氧基) | 1 |
E-5402 | H | H | H | H | H | 3-((4-(三氟甲氧基)苯甲基)氧基) | 1 |
E-5403 | H | H | H | H | H | 4-((4-(三氟甲氧基)苯甲基)氧基) | 1 |
E-5404 | H | H | H | H | H | 2-((2-(甲基硫基)苯甲基)氧基) | 1 |
E-5405 | H | H | H | H | H | 3-((2-(甲基硫基)苯甲基)氧基) | 1 |
E-5406 | H | H | H | H | H | 4-((2-(甲基硫基)苯甲基)氧基) | 1 |
E-5407 | H | H | H | H | H | 2-((3-(甲基硫基)苯甲基)氧基) | 1 |
E-5408 | H | H | H | H | H | 3-((3-(甲基硫基)苯甲基)氧基) | 1 |
E-5409 | H | H | H | H | H | 4-((3-(甲基硫基)苯甲基)氧基) | 1 |
E-5410 | H | H | H | H | H | 2-((4-(甲基硫基)苯甲基)氧基) | 1 |
E-5411 | H | H | H | H | H | 3-((4-(甲基硫基)苯甲基)氧基) | 1 |
E-5412 | H | H | H | H | H | 4-((4-(甲基硫基)苯甲基)氧基) | 1 |
E-5413 | H | H | H | H | H | 2-((2-(甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5414 | H | H | H | H | H | 3-((2-(甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5415 | H | H | H | H | H | 4-((2-(甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5416 | H | H | H | H | H | 2-((3-(甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5417 | H | H | H | H | H | 3-((3-(甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5418 | H | H | H | H | H | 4-((3-(甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5419 | H | H | H | H | H | 2-((4-(甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5420 | H | H | H | H | H | 3-((4-(甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5421 | H | H | H | H | H | 4-((4-(甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5422 | H | H | H | H | H | 2-((2-(甲基磺酰基)苯甲基)氧基) | 1 |
E-5423 | H | H | H | H | H | 3-((2-(甲基磺酰基)苯甲基)氧基) | 1 |
E-5424 | H | H | H | H | H | 4-((2-(甲基磺酰基)苯甲基)氧基) | 1 |
E-5425 | H | H | H | H | H | 2-((3-(甲基磺酰基)苯甲基)氧基) | 1 |
E-5426 | H | H | H | H | H | 3-((3-(甲基磺酰基)苯甲基)氧基) | 1 |
E-5427 | H | H | H | H | H | 4-((3-(甲基磺酰基)苯甲基)氧基) | 1 |
E-5428 | H | H | H | H | H | 2-((4-(甲基磺酰基)苯甲基)氧基) | 1 |
E-5429 | H | H | H | H | H | 3-((4-(甲基磺酰基)苯甲基)氧基) | 1 |
E-5430 | H | H | H | H | H | 4-((4-(甲基磺酰基)苯甲基)氧基) | 1 |
E-5431 | H | H | H | H | H | 2-((2-(三氟甲基硫基)苯甲基)氧基) | 1 |
E-5432 | H | H | H | H | H | 3-((2-(三氟甲基硫基)苯甲基)氧基) | 1 |
E-5433 | H | H | H | H | H | 4-((2-(三氟甲基硫基)苯甲基)氧基) | 1 |
E-5434 | H | H | H | H | H | 2-((3-(三氟甲基硫基)苯甲基)氧基) | 1 |
E-5435 | H | H | H | H | H | 3-((3-(三氟甲基硫基)苯甲基)氧基) | 1 |
E-5436 | H | H | H | H | H | 4-((3-(三氟甲基硫基)苯甲基)氧基) | 1 |
E-5437 | H | H | H | H | H | 2-((4-(三氟甲基硫基)苯甲基)氧基) | 1 |
E-5438 | H | H | H | H | H | 3-((4-(三氟甲基硫基)苯甲基)氧基) | 1 |
E-5439 | H | H | H | H | H | 4-((4-(三氟甲基硫基)苯甲基)氧基) | 1 |
E-5440 | H | H | H | H | H | 2-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5441 | H | H | H | H | H | 3-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5442 | H | H | H | H | H | 4-((2-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5443 | H | H | H | H | H | 2-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5444 | H | H | H | H | H | 3-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5445 | H | H | H | H | H | 4-((3-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5446 | H | H | H | H | H | 2-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5447 | H | H | H | H | H | 3-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5448 | H | H | H | H | H | 4-((4-(三氟甲基亚磺酰基)苯甲基)氧基) | 1 |
E-5449 | H | H | H | H | H | 2-((2-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
E-5450 | H | H | H | H | H | 3-((2-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
E-5451 | H | H | H | H | H | 4-((2-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
[表288]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5452 | H | H | H | H | H | 2-((3-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
E-5453 | H | H | H | H | H | 3-((3-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
E-5454 | H | H | H | H | H | 4-((3-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
E-5455 | H | H | H | H | H | 2-((4-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
E-5456 | H | H | H | H | H | 3-((4-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
E-5457 | H | H | H | H | H | 4-((4-(三氟甲基磺酰基)苯甲基)氧基) | 1 |
E-5458 | H | H | H | H | H | 2-((2-氨基苯甲基)氧基) | 1 |
E-5459 | H | H | H | H | H | 3-((2-氨基苯甲基)氧基) | 1 |
E-5460 | H | H | H | H | H | 4-((2-氨基苯甲基)氧基) | 1 |
E-5461 | H | H | H | H | H | 2-((3-氨基苯甲基)氧基) | 1 |
E-5462 | H | H | H | H | H | 3-((3-氨基苯甲基)氧基) | 1 |
E-5463 | H | H | H | H | H | 4-((3-氨基苯甲基)氧基) | 1 |
E-5464 | H | H | H | H | H | 2-((4-氨基苯甲基)氧基) | 1 |
E-5465 | H | H | H | H | H | 3-((4-氨基苯甲基)氧基) | 1 |
E-5466 | H | H | H | H | H | 4-((4-氨基苯甲基)氧基) | 1 |
E-5467 | H | H | H | H | H | 2-((2-(甲基氨基)苯甲基)氧基) | 1 |
E-5468 | H | H | H | H | H | 3-((2-(甲基氨基)苯甲基)氧基) | 1 |
E-5469 | H | H | H | H | H | 4-((2-(甲基氨基)苯甲基)氧基) | 1 |
E-5470 | H | H | H | H | H | 2-((3-(甲基氨基)苯甲基)氧基) | 1 |
E-5471 | H | H | H | H | H | 3-((3-(甲基氨基)苯甲基)氧基) | 1 |
E-5472 | H | H | H | H | H | 4-((3-(甲基氨基)苯甲基)氧基) | 1 |
E-5473 | H | H | H | H | H | 2-((4-(甲基氨基)苯甲基)氧基) | 1 |
E-5474 | H | H | H | H | H | 3-((4-(甲基氨基)苯甲基)氧基) | 1 |
E-5475 | H | H | H | H | H | 4-((4-(甲基氨基)苯甲基)氧基) | 1 |
E-5476 | H | H | H | H | H | 2-((2-(二甲基氨基)苯甲基)氧基) | 1 |
E-5477 | H | H | H | H | H | 3-((2-(二甲基氨基)苯甲基)氧基) | 1 |
E-5478 | H | H | H | H | H | 4-((2-(二甲基氨基)苯甲基)氧基) | 1 |
E-5479 | H | H | H | H | H | 2-((3-(二甲基氨基)苯甲基)氧基) | 1 |
E-5480 | H | H | H | H | H | 3-((3-(二甲基氨基)苯甲基)氧基) | 1 |
E-5481 | H | H | H | H | H | 4-((3-(二甲基氨基)苯甲基)氧基) | 1 |
E-5482 | H | H | H | H | H | 2-((4-(二甲基氨基)苯甲基)氧基) | 1 |
E-5483 | H | H | H | H | H | 3-((4-(二甲基氨基)苯甲基)氧基) | 1 |
E-5484 | H | H | H | H | H | 4-((4-(二甲基氨基)苯甲基)氧基) | 1 |
E-5485 | H | H | H | H | H | 2-((2-氰基苯甲基)氧基) | 1 |
E-5486 | H | H | H | H | H | 3-((2-氰基苯甲基)氧基) | 1 |
E-5487 | H | H | H | H | H | 4-((2-氰基苯甲基)氧基) | 1 |
E-5488 | H | H | H | H | H | 2-((3-氰基苯甲基)氧基) | 1 |
E-5489 | H | H | H | H | H | 3-((3-氰基苯甲基)氧基) | 1 |
E-5490 | H | H | H | H | H | 4-((3-氰基苯甲基)氧基) | 1 |
E-5491 | H | H | H | H | H | 2-((4-氰基苯甲基)氧基) | 1 |
E-5492 | H | H | H | H | H | 3-((4-氰基苯甲基)氧基) | 1 |
E-5493 | H | H | H | H | H | 4-((4-氰基苯甲基)氧基) | 1 |
E-5494 | H | H | H | H | H | 2-((2-硝基苯甲基)氧基) | 1 |
E-5495 | H | H | H | H | H | 3-((2-硝基苯甲基)氧基) | 1 |
E-5496 | H | H | H | H | H | 4-((2-硝基苯甲基)氧基) | 1 |
E-5497 | H | H | H | H | H | 2-((3-硝基苯甲基)氧基) | 1 |
E-5498 | H | H | H | H | H | 3-((3-硝基苯甲基)氧基) | 1 |
E-5499 | H | H | H | H | H | 4-((3-硝基苯甲基)氧基) | 1 |
E-5500 | H | H | H | H | H | 2-((4-硝基苯甲基)氧基) | 1 |
E-5501 | H | H | H | H | H | 3-((4-硝基苯甲基)氧基) | 1 |
E-5502 | H | H | H | H | H | 4-((4-硝基苯甲基)氧基) | 1 |
E-5503 | H | H | H | H | H | 2-NH2 | 1 |
E-5504 | H | H | H | H | H | 3-NH2 | 1 |
E-5505 | H | H | H | H | H | 4-NH2 | 1 |
E-5506 | H | H | H | H | H | 2-NHMe | 1 |
E-5507 | H | H | H | H | H | 3-NHMe | 1 |
E-5508 | H | H | H | H | H | 4-NHMe | 1 |
[表289]
[表290]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5566 | H | H | H | H | H | 3-F,5-Cl | 1 |
E-5567 | H | H | H | H | H | 3-F,6-Cl | 1 |
E-5568 | H | H | H | H | H | 4-F,2-Cl | 1 |
E-5569 | H | H | H | H | H | 4-F,3-Cl | 1 |
E-5570 | H | H | H | H | H | 2-F,3-Me | 1 |
E-5571 | H | H | H | H | H | 2-F,4-Me | 1 |
E-5572 | H | H | H | H | H | 2-F,5-Me | 1 |
E-5573 | H | H | H | H | H | 2-F,6-Me | 1 |
E-5574 | H | H | H | H | H | 3-F,2-Me | 1 |
E-5575 | H | H | H | H | H | 3-F,4-Me | 1 |
E-5576 | H | H | H | H | H | 3-F,5-Me | 1 |
E-5577 | H | H | H | H | H | 3-F,6-Me | 1 |
E-5578 | H | H | H | H | H | 4-F,2-Me | 1 |
E-5579 | H | H | H | H | H | 4-F,3-Me | 1 |
E-5580 | H | H | H | H | H | 2-F,3-CF<sub>3</sub> | 1 |
E-5581 | H | H | H | H | H | 2-F,4-CF<sub>3</sub> | 1 |
E-5582 | H | H | H | H | H | 2-F,5-CF<sub>3</sub> | 1 |
E-5583 | H | H | H | H | H | 2-F,6-CF<sub>3</sub> | 1 |
E-5584 | H | H | H | H | H | 3-F,2-CF<sub>3</sub> | 1 |
E-5585 | H | H | H | H | H | 3-F,4-CF<sub>3</sub> | 1 |
E-5586 | H | H | H | H | H | 3-F,5-CF<sub>3</sub> | 1 |
E-5587 | H | H | H | H | H | 3-F,6-CF<sub>3</sub> | 1 |
E-5588 | H | H | H | H | H | 4-F,2-CF<sub>3</sub> | 1 |
E-5589 | H | H | H | H | H | 4-F,3-CF<sub>3</sub> | 1 |
E-5590 | H | H | H | H | H | 2-F,3-OMe | 1 |
E-5591 | H | H | H | H | H | 2-F,4-OMe | 1 |
E-5592 | H | H | H | H | H | 2-F,5-OMe | 1 |
E-5593 | H | H | H | H | H | 2-F,6-OMe | 1 |
E-5594 | H | H | H | H | H | 3-F,2-OMe | 1 |
E-5595 | H | H | H | H | H | 3-F,4-OMe | 1 |
E-5596 | H | H | H | H | H | 3-F,5-OMe | 1 |
E-5597 | H | H | H | H | H | 3-F,6-OMe | 1 |
E-5598 | H | H | H | H | H | 4-F,2-OMe | 1 |
E-5599 | H | H | H | H | H | 4-F,3-OMe | 1 |
E-5600 | H | H | H | H | H | 2,3-Cl<sub>2</sub> | 1 |
E-5601 | H | H | H | H | H | 2,4-Cl<sub>2</sub> | 1 |
E-5602 | H | H | H | H | H | 2,5-Cl<sub>2</sub> | 1 |
E-5603 | H | H | H | H | H | 2,6-Cl<sub>2</sub> | 1 |
E-5604 | H | H | H | H | H | 3,4-Cl<sub>2</sub> | 1 |
E-5605 | H | H | H | H | H | 3,5-Cl<sub>2</sub> | 1 |
E-5606 | H | H | H | H | H | 2-Cl,3-Me | 1 |
E-5607 | H | H | H | H | H | 2-Cl,4-Me | 1 |
E-5608 | H | H | H | H | H | 2-Cl,5-Me | 1 |
E-5609 | H | H | H | H | H | 2-Cl,6-Me | 1 |
E-5610 | H | H | H | H | H | 3-Cl,2-Me | 1 |
E-5611 | H | H | H | H | H | 3-Cl,4-Me | 1 |
E-5612 | H | H | H | H | H | 3-Cl,5-Me | 1 |
E-5613 | H | H | H | H | H | 3-Cl,6-Me | 1 |
E-5614 | H | H | H | H | H | 4-Cl,2-Me | 1 |
E-5615 | H | H | H | H | H | 4-Cl,3-Me | 1 |
E-5616 | H | H | H | H | H | 2-Cl,3-CF<sub>3</sub> | 1 |
E-5617 | H | H | H | H | H | 2-Cl,4-CF<sub>3</sub> | 1 |
E-5618 | H | H | H | H | H | 2-Cl,5-CF<sub>3</sub> | 1 |
E-5619 | H | H | H | H | H | 2-Cl,6-CF<sub>3</sub> | 1 |
E-5620 | H | H | H | H | H | 3-Cl,2-CF<sub>3</sub> | 1 |
E-5621 | H | H | H | H | H | 3-Cl,4-CF<sub>3</sub> | 1 |
E-5622 | H | H | H | H | H | 3-Cl,5-CF<sub>3</sub> | 1 |
[表291]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5623 | H | H | H | H | H | 3-Cl,6-CF<sub>3</sub> | 1 |
E-5624 | H | H | H | H | H | 4-Cl,2-CF<sub>3</sub> | 1 |
E-5625 | H | H | H | H | H | 4-Cl,3-CF<sub>3</sub> | 1 |
E-5626 | H | H | H | H | H | 2-Cl,3-OMe | 1 |
E-5627 | H | H | H | H | H | 2-Cl,4-OMe | 1 |
E-5628 | H | H | H | H | H | 2-Cl,5-OMe | 1 |
E-5629 | H | H | H | H | H | 2-Cl,6-OMe | 1 |
E-5630 | H | H | H | H | H | 3-Cl,2-OMe | 1 |
E-5631 | H | H | H | H | H | 3-Cl,4-OMe | 1 |
E-5632 | H | H | H | H | H | 3-Cl,5-OMe | 1 |
E-5633 | H | H | H | H | H | 3-Cl,6-OMe | 1 |
E-5634 | H | H | H | H | H | 4-Cl,2-OMe | 1 |
E-5635 | H | H | H | H | H | 4-Cl,3-OMe | 1 |
E-5636 | H | H | H | H | H | 2,3-Me<sub>2</sub> | 1 |
E-5637 | H | H | H | H | H | 2,4-Me<sub>2</sub> | 1 |
E-5638 | H | H | H | H | H | 2,5-Me<sub>2</sub> | 1 |
E-5639 | H | H | H | H | H | 2,6-Me<sub>2</sub> | 1 |
E-5640 | H | H | H | H | H | 3,4-Me<sub>2</sub> | 1 |
E-5641 | H | H | H | H | H | 3,5-Me<sub>2</sub> | 1 |
E-5642 | H | H | H | H | H | 2-Me,3-CF<sub>3</sub> | 1 |
E-5643 | H | H | H | H | H | 2-Me,4-CF<sub>3</sub> | 1 |
E-5644 | H | H | H | H | H | 2-Me,5-CF<sub>3</sub> | 1 |
E-5645 | H | H | H | H | H | 2-Me,6-CF<sub>3</sub> | 1 |
E-5646 | H | H | H | H | H | 3-Me,2-CF<sub>3</sub> | 1 |
E-5647 | H | H | H | H | H | 3-Me,4-CF<sub>3</sub> | 1 |
E-5648 | H | H | H | H | H | 3-Me,5-CF<sub>3</sub> | 1 |
E-5649 | H | H | H | H | H | 3-Me,6-CF<sub>3</sub> | 1 |
E-5650 | H | H | H | H | H | 4-Me,2-CF<sub>3</sub> | 1 |
E-5651 | H | H | H | H | H | 4-Me,3-CF<sub>3</sub> | 1 |
E-5652 | H | H | H | H | H | 2-Me,3-OMe | 1 |
E-5653 | H | H | H | H | H | 2-Me,4-OMe | 1 |
E-5654 | H | H | H | H | H | 2-Me,5-OMe | 1 |
E-5655 | H | H | H | H | H | 2-Me,6-OMe | 1 |
E-5656 | H | H | H | H | H | 3-Me,2-OMe | 1 |
E-5657 | H | H | H | H | H | 3-Me,4-OMe | 1 |
E-5658 | H | H | H | H | H | 3-Me,5-OMe | 1 |
E-5659 | H | H | H | H | H | 3-Me,6-OMe | 1 |
E-5660 | H | H | H | H | H | 4-Me,2-OMe | 1 |
E-5661 | H | H | H | H | H | 4-Me,3-OMe | 1 |
E-5662 | H | H | H | H | H | 2,3-OMe<sub>2</sub> | 1 |
E-5663 | H | H | H | H | H | 2,4-OMe<sub>2</sub> | 1 |
E-5664 | H | H | H | H | H | 2,5-OMe<sub>2</sub> | 1 |
E-5665 | H | H | H | H | H | 2,6-OMe<sub>2</sub> | 1 |
E-5666 | H | H | H | H | H | 3,4-OMe<sub>2</sub> | 1 |
E-5667 | H | H | H | H | H | 3,5-OMe<sub>2</sub> | 1 |
E-5668 | H | H | H | H | H | 2-OMe,3-CF<sub>3</sub> | 1 |
E-5669 | H | H | H | H | H | 2-OMe,4-CF<sub>3</sub> | 1 |
E-5670 | H | H | H | H | H | 2-OMe,5-CF<sub>3</sub> | 1 |
E-5671 | H | H | H | H | H | 2-OMe,6-CF<sub>3</sub> | 1 |
E-5672 | H | H | H | H | H | 3-OMe,2-CF<sub>3</sub> | 1 |
E-5673 | H | H | H | H | H | 3-OMe,4-CF<sub>3</sub> | 1 |
E-5674 | H | H | H | H | H | 3-OMe,5-CF<sub>3</sub> | 1 |
E-5675 | H | H | H | H | H | 3-OMe,6-CF<sub>3</sub> | 1 |
E-5676 | H | H | H | H | H | 4-OMe,2-CF<sub>3</sub> | 1 |
E-5677 | H | H | H | H | H | 4-OMe,3-CF<sub>3</sub> | 1 |
E-5678 | H | H | H | H | H | 2-CHF<sub>2</sub>,3-F | 1 |
E-5679 | H | H | H | H | H | 2-CHF<sub>2</sub>,4-F | 1 |
[表292]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5680 | H | H | H | H | H | 2-CHF<sub>2</sub>,5-F | 1 |
E-5681 | H | H | H | H | H | 2-CHF<sub>2</sub>,6-F | 1 |
E-5682 | H | H | H | H | H | 2-CHF<sub>2</sub>,3-Me | 1 |
E-5683 | H | H | H | H | H | 2-CHF<sub>2</sub>,4-Me | 1 |
E-5684 | H | H | H | H | H | 2-CHF<sub>2</sub>,5-Me | 1 |
E-5685 | H | H | H | H | H | 2-CHF<sub>2</sub>,6-Me | 1 |
E-5686 | H | H | H | H | H | 2-环丙基,3-F | 1 |
E-5687 | H | H | H | H | H | 2-环丙基,4-F | 1 |
E-5688 | H | H | H | H | H | 2-环丙基,5-F | 1 |
E-5689 | H | H | H | H | H | 2-环丙基,6-F | 1 |
E-5690 | H | H | H | H | H | 2-环丙基,3-Me | 1 |
E-5691 | H | H | H | H | H | 2-环丙基,4-Me | 1 |
E-5692 | H | H | H | H | H | 2-环丙基,5-Me | 1 |
E-5693 | H | H | H | H | H | 2-环丙基,6-Me | 1 |
E-5694 | H | H | H | H | H | 2-乙烯基,3-F | 1 |
E-5695 | H | H | H | H | H | 2-乙烯基,4-F | 1 |
E-5696 | H | H | H | H | H | 2-乙烯基,5-F | 1 |
E-5697 | H | H | H | H | H | 2-乙烯基,6-F | 1 |
E-5698 | H | H | H | H | H | 2-乙烯基,3-Me | 1 |
E-5699 | H | H | H | H | H | 2-乙烯基,4-Me | 1 |
E-5700 | H | H | H | H | H | 2-乙烯基,5-Me | 1 |
E-5701 | H | H | H | H | H | 2-乙烯基,6-Me | 1 |
E-5702 | H | H | H | H | H | 2-OEt,3-F | 1 |
E-5703 | H | H | H | H | H | 2-OEt,4-F | 1 |
E-5704 | H | H | H | H | H | 2-OEt,5-F | 1 |
E-5705 | H | H | H | H | H | 2-OEt,6-F | 1 |
E-5706 | H | H | H | H | H | 2-OEt,3-Cl | 1 |
E-5707 | H | H | H | H | H | 2-OEt,4-Cl | 1 |
E-5708 | H | H | H | H | H | 2-OEt,5-Cl | 1 |
E-5709 | H | H | H | H | H | 2-OEt,6-Cl | 1 |
E-5710 | H | H | H | H | H | 2-OEt,3-Me | 1 |
E-5711 | H | H | H | H | H | 2-OEt,4-Me | 1 |
E-5712 | H | H | H | H | H | 2-OEt,5-Me | 1 |
E-5713 | H | H | H | H | H | 2-OEt,6-Me | 1 |
E-5714 | H | H | H | H | H | 2-OPr,3-F | 1 |
E-5715 | H | H | H | H | H | 2-OPr,4-F | 1 |
E-5716 | H | H | H | H | H | 2-OPr,5-F | 1 |
E-5717 | H | H | H | H | H | 2-OPr,6-F | 1 |
E-5718 | H | H | H | H | H | 2-OPr,3-Me | 1 |
E-5719 | H | H | H | H | H | 2-OPr,4-Me | 1 |
E-5720 | H | H | H | H | H | 2-OPr,5-Me | 1 |
E-5721 | H | H | H | H | H | 2-OPr,6-Me | 1 |
E-5722 | H | H | H | H | H | 2-O(i-Pr),3-F | 1 |
E-5723 | H | H | H | H | H | 2-O(i-Pr),4-F | 1 |
E-5724 | H | H | H | H | H | 2-O(i-Pr),5-F | 1 |
E-5725 | H | H | H | H | H | 2-O(i-Pr),6-F | 1 |
E-5726 | H | H | H | H | H | 2-O(i-Pr),3-Me | 1 |
E-5727 | H | H | H | H | H | 2-O(i-Pr),4-Me | 1 |
E-5728 | H | H | H | H | H | 2-O(i-Pr),5-Me | 1 |
E-5729 | H | H | H | H | H | 2-O(i-Pr),6-Me | 1 |
E-5730 | H | H | H | H | H | 2-OCF<sub>3</sub>,3-F | 1 |
E-5731 | H | H | H | H | H | 2-OCF<sub>3</sub>,4-F | 1 |
E-5732 | H | H | H | H | H | 2-OCF<sub>3</sub>,5-F | 1 |
E-5733 | H | H | H | H | H | 2-OCF<sub>3</sub>,6-F | 1 |
E-5734 | H | H | H | H | H | 2-OCF<sub>3</sub>,3-Me | 1 |
E-5735 | H | H | H | H | H | 2-OCF<sub>3</sub>,4-Me | 1 |
E-5736 | H | H | H | H | H | 2-OCF<sub>3</sub>,5-Me | 1 |
[表293]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5737 | H | H | H | H | H | 2-OCF<sub>3</sub>,6-Me | 1 |
E-5738 | H | H | H | H | H | 2-OCHF<sub>2</sub>,3-F | 1 |
E-5739 | H | H | H | H | H | 2-OCHF<sub>2</sub>,4-F | 1 |
E-5740 | H | H | H | H | H | 2-OCHF<sub>2</sub>,5-F | 1 |
E-5741 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-F | 1 |
E-5742 | H | H | H | H | H | 2-OCHF<sub>2</sub>,3-Me | 1 |
E-5743 | H | H | H | H | H | 2-OCHF<sub>2</sub>,4-Me | 1 |
E-5744 | H | H | H | H | H | 2-OCHF<sub>2</sub>,5-Me | 1 |
E-5745 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-Me | 1 |
E-5746 | H | H | H | H | H | 2-(环丙基氧基),3-F | 1 |
E-5747 | H | H | H | H | H | 2-(环丙基氧基),4-F | 1 |
E-5748 | H | H | H | H | H | 2-(环丙基氧基),5-F | 1 |
E-5749 | H | H | H | H | H | 2-(环丙基氧基),6-F | 1 |
E-5750 | H | H | H | H | H | 2-(环丙基氧基),3-Me | 1 |
E-5751 | H | H | H | H | H | 2-(环丙基氧基),4-Me | 1 |
E-5752 | H | H | H | H | H | 2-(环丙基氧基),5-Me | 1 |
E-5753 | H | H | H | H | H | 2-(环丙基氧基),6-Me | 1 |
E-5754 | H | H | H | H | H | 2-(环氧乙烷-2-基),3-F | 1 |
E-5755 | H | H | H | H | H | 2-(环氧乙烷-2-基),4-F | 1 |
E-5756 | H | H | H | H | H | 2-(环氧乙烷-2-基),5-F | 1 |
E-5757 | H | H | H | H | H | 2-(环氧乙烷-2-基),6-F | 1 |
E-5758 | H | H | H | H | H | 2-(环氧乙烷-2-基),3-Me | 1 |
E-5759 | H | H | H | H | H | 2-(环氧乙烷-2-基),4-Me | 1 |
E-5760 | H | H | H | H | H | 2-(环氧乙烷-2-基),5-Me | 1 |
E-5761 | H | H | H | H | H | 2-(环氧乙烷-2-基),6-Me | 1 |
E-5762 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),3-F | 1 |
E-5763 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),4-F | 1 |
E-5764 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),5-F | 1 |
E-5765 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),6-F | 1 |
E-5766 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),3-Me | 1 |
E-5767 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),4-Me | 1 |
E-5768 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),5-Me | 1 |
E-5769 | H | H | H | H | H | 2-(环氧乙烷-2-基甲基),6-Me | 1 |
E-5770 | H | H | H | H | H | 2-SMe,3-F | 1 |
E-5771 | H | H | H | H | H | 2-SMe,4-F | 1 |
E-5772 | H | H | H | H | H | 2-SMe,5-F | 1 |
E-5773 | H | H | H | H | H | 2-SMe,6-F | 1 |
E-5774 | H | H | H | H | H | 2-SMe,3-Me | 1 |
E-5775 | H | H | H | H | H | 2-SMe,4-Me | 1 |
E-5776 | H | H | H | H | H | 2-SMe,5-Me | 1 |
E-5777 | H | H | H | H | H | 2-SMe,6-Me | 1 |
E-5778 | H | H | H | H | H | 2-SEt,3-F | 1 |
E-5779 | H | H | H | H | H | 2-SEt,4-F | 1 |
E-5780 | H | H | H | H | H | 2-SEt,5-F | 1 |
E-5781 | H | H | H | H | H | 2-SEt,6-F | 1 |
E-5782 | H | H | H | H | H | 2-SEt,3-Me | 1 |
E-5783 | H | H | H | H | H | 2-SEt,4-Me | 1 |
E-5784 | H | H | H | H | H | 2-SEt,5-Me | 1 |
E-5785 | H | H | H | H | H | 2-SEt,6-Me | 1 |
E-5786 | H | H | H | H | H | 2-S(=O)Me,3-F | 1 |
E-5787 | H | H | H | H | H | 2-S(=O)Me,4-F | 1 |
E-5788 | H | H | H | H | H | 2-S(=O)Me,5-F | 1 |
E-5789 | H | H | H | H | H | 2-S(=O)Me,6-F | 1 |
E-5790 | H | H | H | H | H | 3-S(=O)Me,2-F | 1 |
E-5791 | H | H | H | H | H | 3-S(=O)Me,4-F | 1 |
E-5792 | H | H | H | H | H | 3-S(=O)Me,5-F | 1 |
E-5793 | H | H | H | H | H | 3-S(=O)Me,6-F | 1 |
[表294]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5794 | H | H | H | H | H | 2-S(=O)Me,3-Me | 1 |
E-5795 | H | H | H | H | H | 2-S(=O)Me,4-Me | 1 |
E-5796 | H | H | H | H | H | 2-S(=O)Me,5-Me | 1 |
E-5797 | H | H | H | H | H | 2-S(=O)Me,6-Me | 1 |
E-5798 | H | H | H | H | H | 3-S(=O)Me,2-Me | 1 |
E-5799 | H | H | H | H | H | 3-S(=O)Me,4-Me | 1 |
E-5800 | H | H | H | H | H | 3-S(=O)Me,5-Me | 1 |
E-5801 | H | H | H | H | H | 3-S(=O)Me,6-Me | 1 |
E-5802 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,3-F | 1 |
E-5803 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,4-F | 1 |
E-5804 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,5-F | 1 |
E-5805 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,6-F | 1 |
E-5806 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,3-Me | 1 |
E-5807 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,4-Me | 1 |
E-5808 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,5-Me | 1 |
E-5809 | H | H | H | H | H | 2-S(=O)<sub>2</sub>Me,6-Me | 1 |
E-5810 | H | H | H | H | H | 2-SCF<sub>3</sub>,3-F | 1 |
E-5811 | H | H | H | H | H | 2-SCF<sub>3</sub>,4-F | 1 |
E-5812 | H | H | H | H | H | 2-SCF<sub>3</sub>,5-F | 1 |
E-5813 | H | H | H | H | H | 2-SCF<sub>3</sub>,6-F | 1 |
E-5814 | H | H | H | H | H | 2-SCF<sub>3</sub>,3-Me | 1 |
E-5815 | H | H | H | H | H | 2-SCF<sub>3</sub>,4-Me | 1 |
E-5816 | H | H | H | H | H | 2-SCF<sub>3</sub>,5-Me | 1 |
E-5817 | H | H | H | H | H | 2-SCF<sub>3</sub>,6-Me | 1 |
E-5818 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,3-F | 1 |
E-5819 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,4-F | 1 |
E-5820 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,5-F | 1 |
E-5821 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,6-F | 1 |
E-5822 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,3-Me | 1 |
E-5823 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,4-Me | 1 |
E-5824 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,5-Me | 1 |
E-5825 | H | H | H | H | H | 2-S(=O)CF<sub>3</sub>,6-Me | 1 |
E-5826 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-F | 1 |
E-5827 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-F | 1 |
E-5828 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-F | 1 |
E-5829 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-F | 1 |
E-5830 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,3-Me | 1 |
E-5831 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,4-Me | 1 |
E-5832 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,5-Me | 1 |
E-5833 | H | H | H | H | H | 2-S(=O)<sub>2</sub>CF<sub>3</sub>,6-Me | 1 |
E-5834 | H | H | H | H | H | 2-(环丙基硫基),3-F | 1 |
E-5835 | H | H | H | H | H | 2-(环丙基硫基),4-F | 1 |
E-5836 | H | H | H | H | H | 2-(环丙基硫基),5-F | 1 |
E-5837 | H | H | H | H | H | 2-(环丙基硫基),6-F | 1 |
E-5838 | H | H | H | H | H | 2-(环丙基硫基),3-Me | 1 |
E-5839 | H | H | H | H | H | 2-(环丙基硫基),4-Me | 1 |
E-5840 | H | H | H | H | H | 2-(环丙基硫基),5-Me | 1 |
E-5841 | H | H | H | H | H | 2-(环丙基硫基),6-Me | 1 |
E-5842 | H | H | H | H | H | 2-C(=O)Me,3-F | 1 |
E-5843 | H | H | H | H | H | 2-C(=O)Me,4-F | 1 |
E-5844 | H | H | H | H | H | 2-C(=O)Me,5-F | 1 |
E-5845 | H | H | H | H | H | 2-C(=O)Me,6-F | 1 |
E-5846 | H | H | H | H | H | 2-C(=O)Me,3-Me | 1 |
E-5847 | H | H | H | H | H | 2-C(=O)Me,4-Me | 1 |
E-5848 | H | H | H | H | H | 2-C(=O)Me,5-Me | 1 |
E-5849 | H | H | H | H | H | 2-C(=O)Me,6-Me | 1 |
E-5850 | H | H | H | H | H | 3-C(=O)Me,2-F | 1 |
[表295]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5851 | H | H | H | H | H | 3-C(=O)Me,4-F | 1 |
E-5852 | H | H | H | H | H | 3-C(=O)Me,5-F | 1 |
E-5853 | H | H | H | H | H | 3-C(=O)Me,6-F | 1 |
E-5854 | H | H | H | H | H | 3-C(=O)Me,2-Me | 1 |
E-5855 | H | H | H | H | H | 3-C(=O)Me,4-Me | 1 |
E-5856 | H | H | H | H | H | 3-C(=O)Me,5-Me | 1 |
E-5857 | H | H | H | H | H | 3-C(=O)Me,6-Me | 1 |
E-5858 | H | H | H | H | H | 2-C(=O)OMe,3-F | 1 |
E-5859 | H | H | H | H | H | 2-C(=O)OMe,4-F | 1 |
E-5860 | H | H | H | H | H | 2-C(=O)OMe,5-F | 1 |
E-5861 | H | H | H | H | H | 2-C(=O)OMe,6-F | 1 |
E-5862 | H | H | H | H | H | 2-C(=O)OMe,3-Me | 1 |
E-5863 | H | H | H | H | H | 2-C(=O)OMe,4-Me | 1 |
E-5864 | H | H | H | H | H | 2-C(=O)OMe,5-Me | 1 |
E-5865 | H | H | H | H | H | 2-C(=O)OMe,6-Me | 1 |
E-5866 | H | H | H | H | H | 2-C(=O)OEt,3-F | 1 |
E-5867 | H | H | H | H | H | 2-C(=O)OEt,4-F | 1 |
E-5868 | H | H | H | H | H | 2-C(=O)OEt,5-F | 1 |
E-5869 | H | H | H | H | H | 2-C(=O)OEt,6-F | 1 |
E-5870 | H | H | H | H | H | 2-C(=O)OEt,3-Me | 1 |
E-5871 | H | H | H | H | H | 2-C(=O)OEt,4-Me | 1 |
E-5872 | H | H | H | H | H | 2-C(=O)OEt,5-Me | 1 |
E-5873 | H | H | H | H | H | 2-C(=O)OEt,6-Me | 1 |
E-5874 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,3-F | 1 |
E-5875 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,4-F | 1 |
E-5876 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,5-F | 1 |
E-5877 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,6-F | 1 |
E-5878 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,3-Me | 1 |
E-5879 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,4-Me | 1 |
E-5880 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,5-Me | 1 |
E-5881 | H | H | H | H | H | 2-C(=O)NH<sub>2</sub>,6-Me | 1 |
E-5882 | H | H | H | H | H | 2-C(=O)NHMe,3-F | 1 |
E-5883 | H | H | H | H | H | 2-C(=O)NHMe,4-F | 1 |
E-5884 | H | H | H | H | H | 2-C(=O)NHMe,5-F | 1 |
E-5885 | H | H | H | H | H | 2-C(=O)NHMe,6-F | 1 |
E-5886 | H | H | H | H | H | 2-C(=O)NHMe,3-Me | 1 |
E-5887 | H | H | H | H | H | 2-C(=O)NHMe,4-Me | 1 |
E-5888 | H | H | H | H | H | 2-C(=O)NHMe,5-Me | 1 |
E-5889 | H | H | H | H | H | 2-C(=O)NHMe,6-Me | 1 |
E-5890 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,3-F | 1 |
E-5891 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,4-F | 1 |
E-5892 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,5-F | 1 |
E-5893 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,6-F | 1 |
E-5894 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,3-Me | 1 |
E-5895 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,4-Me | 1 |
E-5896 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,5-Me | 1 |
E-5897 | H | H | H | H | H | 2-C(=O)NMe<sub>2</sub>,6-Me | 1 |
E-5898 | H | H | H | H | H | 2-CH<sub>2</sub>OH,3-F | 1 |
E-5899 | H | H | H | H | H | 2-CH<sub>2</sub>OH,4-F | 1 |
E-5900 | H | H | H | H | H | 2-CH<sub>2</sub>OH,5-F | 1 |
E-5901 | H | H | H | H | H | 2-CH<sub>2</sub>OH,6-F | 1 |
E-5902 | H | H | H | H | H | 2-CH<sub>2</sub>OH,3-Me | 1 |
E-5903 | H | H | H | H | H | 2-CH<sub>2</sub>OH,4-Me | 1 |
E-5904 | H | H | H | H | H | 2-CH<sub>2</sub>OH,5-Me | 1 |
E-5905 | H | H | H | H | H | 2-CH<sub>2</sub>OH,6-Me | 1 |
E-5906 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-F | 1 |
E-5907 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-F | 1 |
[表296]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5908 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-F | 1 |
E-5909 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-F | 1 |
E-5910 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,3-Me | 1 |
E-5911 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,4-Me | 1 |
E-5912 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-Me | 1 |
E-5913 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Me | 1 |
E-5914 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-F | 1 |
E-5915 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-F | 1 |
E-5916 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-F | 1 |
E-5917 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-F | 1 |
E-5918 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,3-Me | 1 |
E-5919 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,4-Me | 1 |
E-5920 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,5-Me | 1 |
E-5921 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Me | 1 |
E-5922 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,3-F | 1 |
E-5923 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,4-F | 1 |
E-5924 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,5-F | 1 |
E-5925 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,6-F | 1 |
E-5926 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,3-Me | 1 |
E-5927 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,4-Me | 1 |
E-5928 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,5-Me | 1 |
E-5929 | H | H | H | H | H | 2-OC(=O)CH<sub>3</sub>,6-Me | 1 |
E-5930 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-F | 1 |
E-5931 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-F | 1 |
E-5932 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-F | 1 |
E-5933 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-F | 1 |
E-5934 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,3-Me | 1 |
E-5935 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,4-Me | 1 |
E-5936 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,5-Me | 1 |
E-5937 | H | H | H | H | H | 2-OS(=O)<sub>2</sub>CH<sub>3</sub>,6-Me | 1 |
E-5938 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-F | 1 |
E-5939 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-F | 1 |
E-5940 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-F | 1 |
E-5941 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-F | 1 |
E-5942 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,3-Me | 1 |
E-5943 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,4-Me | 1 |
E-5944 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,5-Me | 1 |
E-5945 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-Me | 1 |
E-5946 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-F | 1 |
E-5947 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-F | 1 |
E-5948 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-F | 1 |
E-5949 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-F | 1 |
E-5950 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,3-Me | 1 |
E-5951 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,4-Me | 1 |
E-5952 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,5-Me | 1 |
E-5953 | H | H | H | H | H | 2-CH<sub>2</sub>SCF<sub>3</sub>,6-Me | 1 |
E-5954 | H | H | H | H | H | 2-(苯甲基氧基),3-F | 1 |
E-5955 | H | H | H | H | H | 2-(苯甲基氧基),4-F | 1 |
E-5956 | H | H | H | H | H | 2-(苯甲基氧基),5-F | 1 |
E-5957 | H | H | H | H | H | 2-(苯甲基氧基),6-F | 1 |
E-5958 | H | H | H | H | H | 2-(苯甲基氧基),3-Me | 1 |
E-5959 | H | H | H | H | H | 2-(苯甲基氧基),4-Me | 1 |
E-5960 | H | H | H | H | H | 2-(苯甲基氧基),5-Me | 1 |
E-5961 | H | H | H | H | H | 2-(苯甲基氧基),6-Me | 1 |
E-5962 | H | H | H | H | H | 2-NH<sub>2</sub>,3-F | 1 |
E-5963 | H | H | H | H | H | 2-NH<sub>2</sub>,4-F | 1 |
E-5964 | H | H | H | H | H | 2-NH<sub>2</sub>,5-F | 1 |
[表297]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-5965 | H | H | H | H | H | 2-NH<sub>2</sub>,6-F | 1 |
E-5966 | H | H | H | H | H | 2-NH<sub>2</sub>,3-Me | 1 |
E-5967 | H | H | H | H | H | 2-NH<sub>2</sub>,4-Me | 1 |
E-5968 | H | H | H | H | H | 2-NH<sub>2</sub>,5-Me | 1 |
E-5969 | H | H | H | H | H | 2-NH<sub>2</sub>,6-Me | 1 |
E-5970 | H | H | H | H | H | 2-NHMe,3-F | 1 |
E-5971 | H | H | H | H | H | 2-NHMe,4-F | 1 |
E-5972 | H | H | H | H | H | 2-NHMe,5-F | 1 |
E-5973 | H | H | H | H | H | 2-NHMe,6-F | 1 |
E-5974 | H | H | H | H | H | 2-NHMe,3-Me | 1 |
E-5975 | H | H | H | H | H | 2-NHMe,4-Me | 1 |
E-5976 | H | H | H | H | H | 2-NHMe,5-Me | 1 |
E-5977 | H | H | H | H | H | 2-NHMe,6-Me | 1 |
E-5978 | H | H | H | H | H | 2-NHEt,3-F | 1 |
E-5979 | H | H | H | H | H | 2-NHEt,4-F | 1 |
E-5980 | H | H | H | H | H | 2-NHEt,5-F | 1 |
E-5981 | H | H | H | H | H | 2-NHEt,6-F | 1 |
E-5982 | H | H | H | H | H | 2-NHEt,3-Me | 1 |
E-5983 | H | H | H | H | H | 2-NHEt,4-Me | 1 |
E-5984 | H | H | H | H | H | 2-NHEt,5-Me | 1 |
E-5985 | H | H | H | H | H | 2-NHEt,6-Me | 1 |
E-5986 | H | H | H | H | H | 2-NMe<sub>2</sub>,3-F | 1 |
E-5987 | H | H | H | H | H | 2-NMe<sub>2</sub>,4-F | 1 |
E-5988 | H | H | H | H | H | 2-NMe<sub>2</sub>,5-F | 1 |
E-5989 | H | H | H | H | H | 2-NMe<sub>2</sub>,6-F | 1 |
E-5990 | H | H | H | H | H | 2-NMe<sub>2</sub>,3-Me | 1 |
E-5991 | H | H | H | H | H | 2-NMe<sub>2</sub>,4-Me | 1 |
E-5992 | H | H | H | H | H | 2-NMe<sub>2</sub>,5-Me | 1 |
E-5993 | H | H | H | H | H | 2-NMe<sub>2</sub>,6-Me | 1 |
E-5994 | H | H | H | H | H | 2-NEt<sub>2</sub>,3-F | 1 |
E-5995 | H | H | H | H | H | 2-NEt<sub>2</sub>,4-F | 1 |
E-5996 | H | H | H | H | H | 2-NEt<sub>2</sub>,5-F | 1 |
E-5997 | H | H | H | H | H | 2-NEt<sub>2</sub>,6-F | 1 |
E-5998 | H | H | H | H | H | 2-NEt<sub>2</sub>,3-Me | 1 |
E-5999 | H | H | H | H | H | 2-NEt<sub>2</sub>,4-Me | 1 |
E-6000 | H | H | H | H | H | 2-NEt<sub>2</sub>,5-Me | 1 |
E-6001 | H | H | H | H | H | 2-NEt<sub>2</sub>,6-Me | 1 |
E-6002 | H | H | H | H | H | 2-CHO,3-F | 1 |
E-6003 | H | H | H | H | H | 2-CHO,4-F | 1 |
E-6004 | H | H | H | H | H | 2-CHO,5-F | 1 |
E-6005 | H | H | H | H | H | 2-CHO,6-F | 1 |
E-6006 | H | H | H | H | H | 2-CHO,3-Me | 1 |
E-6007 | H | H | H | H | H | 2-CHO,4-Me | 1 |
E-6008 | H | H | H | H | H | 2-CHO,5-Me | 1 |
E-6009 | H | H | H | H | H | 2-CHO,6-Me | 1 |
E-6010 | H | H | H | H | H | 2-C(=O)OH,3-F | 1 |
E-6011 | H | H | H | H | H | 2-C(=O)OH,4-F | 1 |
E-6012 | H | H | H | H | H | 2-C(=O)OH,5-F | 1 |
E-6013 | H | H | H | H | H | 2-C(=O)OH,6-F | 1 |
E-6014 | H | H | H | H | H | 2-C(=O)OH,3-Me | 1 |
E-6015 | H | H | H | H | H | 2-C(=O)OH,4-Me | 1 |
E-6016 | H | H | H | H | H | 2-C(=O)OH,5-Me | 1 |
E-6017 | H | H | H | H | H | 2-C(=O)OH,6-Me | 1 |
E-6018 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),3-F | 1 |
E-6019 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),4-F | 1 |
E-6020 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),5-F | 1 |
E-6021 | H | H | H | H | H | 2-(1,3-二氧杂环戊烷-2-基),6-F | 1 |
[表298]
[表299]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-6079 | H | H | H | H | H | 2-CN,4-OMe | 1 |
E-6080 | H | H | H | H | H | 2-CN,5-OMe | 1 |
E-6081 | H | H | H | H | H | 2-CN,6-OMe | 1 |
E-6082 | H | H | H | H | H | 3-CN,2-F | 1 |
E-6083 | H | H | H | H | H | 3-CN,4-F | 1 |
E-6084 | H | H | H | H | H | 3-CN,5-F | 1 |
E-6085 | H | H | H | H | H | 3-CN,6-F | 1 |
E-6086 | H | H | H | H | H | 3-CN,2-Cl | 1 |
E-6087 | H | H | H | H | H | 3-CN,4-Cl | 1 |
E-6088 | H | H | H | H | H | 3-CN,5-Cl | 1 |
E-6089 | H | H | H | H | H | 3-CN,6-Cl | 1 |
E-6090 | H | H | H | H | H | 3-CN,2-Me | 1 |
E-6091 | H | H | H | H | H | 3-CN,4-Me | 1 |
E-6092 | H | H | H | H | H | 3-CN,5-Me | 1 |
E-6093 | H | H | H | H | H | 3-CN,6-Me | 1 |
E-6094 | H | H | H | H | H | 3-CN,2-OMe | 1 |
E-6095 | H | H | H | H | H | 3-CN,4-OMe | 1 |
E-6096 | H | H | H | H | H | 3-CN,5-OMe | 1 |
E-6097 | H | H | H | H | H | 3-CN,6-OMe | 1 |
E-6098 | H | H | H | H | H | 4-CN,2-F | 1 |
E-6099 | H | H | H | H | H | 4-CN,3-F | 1 |
E-6100 | H | H | H | H | H | 4-CN,2-Cl | 1 |
E-6101 | H | H | H | H | H | 4-CN,3-Cl | 1 |
E-6102 | H | H | H | H | H | 4-CN,2-Me | 1 |
E-6103 | H | H | H | H | H | 4-CN,3-Me | 1 |
E-6104 | H | H | H | H | H | 4-CN,2-OMe | 1 |
E-6105 | H | H | H | H | H | 4-CN,3-OMe | 1 |
E-6106 | H | H | H | H | H | 2-NO<sub>2</sub>,3-F | 1 |
E-6107 | H | H | H | H | H | 2-NO<sub>2</sub>,4-F | 1 |
E-6108 | H | H | H | H | H | 2-NO<sub>2</sub>,5-F | 1 |
E-6109 | H | H | H | H | H | 2-NO<sub>2</sub>,6-F | 1 |
E-6110 | H | H | H | H | H | 2-NO<sub>2</sub>,3-Me | 1 |
E-6111 | H | H | H | H | H | 2-NO<sub>2</sub>,4-Me | 1 |
E-6112 | H | H | H | H | H | 2-NO<sub>2</sub>,5-Me | 1 |
E-6113 | H | H | H | H | H | 2-NO<sub>2</sub>,6-Me | 1 |
E-6114 | H | H | H | H | H | 2-Me,3,4-F<sub>2</sub> | 1 |
E-6115 | H | H | H | H | H | 2-Me,3,5-F<sub>2</sub> | 1 |
E-6116 | H | H | H | H | H | 2-Me,3,6-F<sub>2</sub> | 1 |
E-6117 | H | H | H | H | H | 2-Me,4,5-F<sub>2</sub> | 1 |
E-6118 | H | H | H | H | H | 2-OMe,3,4-F<sub>2</sub> | 1 |
E-6119 | H | H | H | H | H | 2-OMe,3,5-F<sub>2</sub> | 1 |
E-6120 | H | H | H | H | H | 2-OMe,3,6-F<sub>2</sub> | 1 |
E-6121 | H | H | H | H | H | 2-OMe,4,5-F<sub>2</sub> | 1 |
E-6122 | H | H | H | H | H | 2-(CH<sub>2</sub>)<sub>3</sub>-3 | 1 |
E-6123 | H | H | H | H | H | 2-(CH<sub>2</sub>)<sub>4</sub>-3 | 1 |
E-6124 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>)-3 | 1 |
E-6125 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-3 | 1 |
E-6126 | H | H | H | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>O)-3 | 1 |
E-6127 | H | H | H | H | H | 2-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-3 | 1 |
E-6128 | H | H | H | H | H | 3-(CH<sub>2</sub>)<sub>3</sub>-4 | 1 |
E-6129 | H | H | H | H | H | 3-(CH<sub>2</sub>)<sub>4</sub>-4 | 1 |
E-6130 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>)-4 | 1 |
E-6131 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>)-4 | 1 |
E-6132 | H | H | H | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>O)-4 | 1 |
E-6133 | H | H | H | H | H | 3-(CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>O)-4 | 1 |
E-6134 | H | H | H | H | H | 2-(OCH<sub>2</sub>O)-3 | 1 |
E-6135 | H | H | H | H | H | 3-(OCH<sub>2</sub>O)-4 | 1 |
[表300]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | (R<sup>8</sup>)<sub>m</sub> | p |
E-6136 | H | H | H | H | H | 2-(OCH<sub>2</sub>CH<sub>2</sub>O)-3 | 1 |
E-6137 | H | H | H | H | H | 3-(OCH<sub>2</sub>CH<sub>2</sub>O)-4 | 1 |
E-6138 | H | H | H | H | H | 2-(OCF<sub>2</sub>O)-3 | 1 |
E-6139 | H | H | H | H | H | 3-(OCF<sub>2</sub>O)-4 | 1 |
E-6140 | H | H | H | H | H | 2-Me,6-Et | 1 |
E-6141 | H | H | H | H | H | 2-Me,4,5-F<sub>2</sub> | 1 |
E-6142 | H | H | H | H | H | 2-环丙基,6-OMe | 1 |
E-6143 | H | H | H | H | H | 2-Me,5-Et | 1 |
E-6144 | H | H | H | H | H | 2,6-Et<sub>2</sub> | 1 |
E-6145 | H | H | H | H | H | 2-Et,6-F | 1 |
E-6146 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-Cl | 1 |
E-6147 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>2</sub>CH<sub>3</sub>,6-Cl | 1 |
E-6148 | H | H | H | H | H | 2-CH<sub>2</sub>NMe<sub>2</sub> | 1 |
E-6149 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,5-OMe | 1 |
E-6150 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-OMe | 1 |
E-6151 | H | H | H | H | H | 2-CH<sub>2</sub>OCH<sub>3</sub>,6-CN | 1 |
E-6152 | H | H | H | H | H | 2-OEt,6-CN | 1 |
E-6153 | H | H | H | H | H | 2-OEt,6-OMe | 1 |
E-6154 | H | H | H | H | H | 2,6-OEt<sub>2</sub> | 1 |
E-6155 | H | H | H | H | H | 2-CN,6-环丙基 | 1 |
E-6156 | H | H | H | H | H | 2-MeO,3-Me,6-MeO | 1 |
E-6157 | H | H | H | H | H | 2-MeO,4-Me,6-MeO | 1 |
E-6158 | H | H | H | H | H | 2-MeO,3-F,6-MeO | 1 |
E-6159 | H | H | H | H | H | 2-MeO,4-F,6-MeO | 1 |
E-6160 | H | H | H | H | H | 2-Et,6-OEt | 1 |
E-6161 | H | H | H | H | H | 2-环丙基,6-OEt | 1 |
E-6162 | H | H | H | H | H | 2,6-SMe<sub>2</sub> | 1 |
E-6163 | H | H | H | H | H | 2-NO<sub>2</sub>,6-OMe | 1 |
E-6164 | H | H | H | H | H | 2-NO<sub>2</sub>,6-CN | 1 |
E-6165 | H | H | H | H | H | 2-Cl,6-NO<sub>2</sub> | 1 |
E-6166 | H | H | H | H | H | 2-Cl,6-SMe | 1 |
E-6167 | H | H | H | H | H | 2-Cl,6-Et | 1 |
E-6168 | H | H | H | H | H | 2-CN,6-SMe | 1 |
E-6169 | H | H | H | H | H | 2,6-CN<sub>2</sub> | 1 |
E-6170 | H | H | H | H | H | 2-OMe,6-OCF<sub>3</sub> | 1 |
E-6171 | H | H | H | H | H | 2-CH<sub>2</sub>SCH<sub>3</sub>,6-OMe | 1 |
E-6172 | H | H | H | H | H | 2-OCHF<sub>2</sub>,6-OMe | 1 |
E-6173 | H | H | H | H | H | 2-Cl,6-CH<sub>2</sub>SCH<sub>3</sub> | 1 |
E-6174 | H | H | H | H | H | 2-CN,6-Et | 1 |
E-6175 | H | H | H | H | H | 2-Et,6-OMe | 1 |
E-6176 | H | H | H | H | H | 2-(吡啶-2-基) | 1 |
E-6177 | H | H | H | H | H | 3-(吡啶-2-基) | 1 |
E-6178 | H | H | H | H | H | 4-(吡啶-2-基) | 1 |
E-6179 | H | H | H | H | H | 2-(嘧啶-2-基) | 1 |
E-6180 | H | H | H | H | H | 3-(嘧啶-2-基) | 1 |
E-6181 | H | H | H | H | H | 4-(嘧啶-2-基) | 1 |
E-6182 | H | H | H | H | H | 2-(吡嗪-2-基) | 1 |
E-6183 | H | H | H | H | H | 3-(吡嗪-2-基) | 1 |
E-6184 | H | H | H | H | H | 4-(吡嗪-2-基) | 1 |
E-6185 | H | H | H | H | H | 2-(1,3,5-三嗪-2-基) | 1 |
E-6186 | H | H | H | H | H | 3-(1,3,5-三嗪-2-基) | 1 |
E-6187 | H | H | H | H | H | 4-(1,3,5-三嗪-2-基) | 1 |
E-6188 | H | H | H | H | H | 2-(1,2,4-三嗪-3-基) | 1 |
E-6189 | H | H | H | H | H | 3-(1,2,4-三嗪-3-基) | 1 |
E-6190 | H | H | H | H | H | 4-(1,2,4-三嗪-3-基) | 1 |
E-6191 | H | H | H | H | H | 2-(1,2,4-三嗪-6-基) | 1 |
[表301]
化合物编号 | R1 | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
E-6192 | H | H | H | H | H | 3-(1,2,4-三嗪-6-基) | 1 |
E-6193 | H | H | H | H | H | 4-(1,2,4-三嗪-6-基) | 1 |
E-6194 | H | H | H | H | H | 2-(1H-吡唑-1-基) | 1 |
E-6195 | H | H | H | H | H | 3-(1H-吡唑-1-基) | 1 |
E-6196 | H | H | H | H | H | 4-(1H-吡唑-1-基) | 1 |
[表302]
[表303]
化合物编号 | R1 | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-0053 | H | H | H | H | H | 3-F-4-Cl-吡啶-2-基 | 0 |
F-0054 | H | H | H | H | H | 3-F-5-Cl-吡啶-2-基 | 0 |
F-0055 | H | H | H | H | H | 3-F-6-Cl-吡啶-2-基 | 0 |
F-0056 | H | H | H | H | H | 3-F-4-Me-吡啶-2-基 | 0 |
F-0057 | H | H | H | H | H | 3-F-5-Me-吡啶-2-基 | 0 |
F-0058 | H | H | H | H | H | 3-F-6-Me-吡啶-2-基 | 0 |
F-0059 | H | H | H | H | H | 3-F-4-OMe-吡啶-2-基 | 0 |
F-0060 | H | H | H | H | H | 3-F-5-OMe-吡啶-2-基 | 0 |
F-0061 | H | H | H | H | H | 3-F-6-OMe-吡啶-2-基 | 0 |
F-0062 | H | H | H | H | H | 3-Cl-4-F-吡啶-2-基 | 0 |
F-0063 | H | H | H | H | H | 3-Cl-5-F-吡啶-2-基 | 0 |
F-0064 | H | H | H | H | H | 3-Cl-6-F-吡啶-2-基 | 0 |
F-0065 | H | H | H | H | H | 3-Cl-4-Me-吡啶-2-基 | 0 |
F-0066 | H | H | H | H | H | 3-Cl-5-Me-吡啶-2-基 | 0 |
F-0067 | H | H | H | H | H | 3-Cl-6-Me-吡啶-2-基 | 0 |
F-0068 | H | H | H | H | H | 3-Me-4-F-吡啶-2-基 | 0 |
F-0069 | H | H | H | H | H | 3-Me-5-F-吡啶-2-基 | 0 |
F-0070 | H | H | H | H | H | 3-Me-6-F-吡啶-2-基 | 0 |
F-0071 | H | H | H | H | H | 3-Me-4-Cl-吡啶-2-基 | 0 |
F-0072 | H | H | H | H | H | 3-Me-5-Cl-吡啶-2-基 | 0 |
F-0073 | H | H | H | H | H | 3-Me-6-Cl-吡啶-2-基 | 0 |
F-0074 | H | H | H | H | H | 3,4-(Me)<sub>2</sub>-吡啶-2-基 | 0 |
F-0075 | H | H | H | H | H | 3,5-(Me)<sub>2</sub>-吡啶-2-基 | 0 |
F-0076 | H | H | H | H | H | 3,6-(Me)<sub>2</sub>-吡啶-2-基 | 0 |
F-0077 | H | H | H | H | H | 3-Me-4-OMe-吡啶-2-基 | 0 |
F-0078 | H | H | H | H | H | 3-Me-5-OMe-吡啶-2-基 | 0 |
F-0079 | H | H | H | H | H | 3-Me-6-OMe-吡啶-2-基 | 0 |
F-0080 | H | H | H | H | H | 3-CF<sub>3</sub>-4-F-吡啶-2-基 | 0 |
F-0081 | H | H | H | H | H | 3-CF<sub>3</sub>-5-F-吡啶-2-基 | 0 |
F-0082 | H | H | H | H | H | 3-CF<sub>3</sub>-6-F-吡啶-2-基 | 0 |
F-0083 | H | H | H | H | H | 3-CF<sub>3</sub>-4-Me-吡啶-2-基 | 0 |
F-0084 | H | H | H | H | H | 3-CF<sub>3</sub>-5-Me-吡啶-2-基 | 0 |
F-0085 | H | H | H | H | H | 3-CF<sub>3</sub>-6-Me-吡啶-2-基 | 0 |
F-0086 | H | H | H | H | H | 3-OMe-4-F-吡啶-2-基 | 0 |
F-0087 | H | H | H | H | H | 3-OMe-5-F-吡啶-2-基 | 0 |
F-0088 | H | H | H | H | H | 3-OMe-6-F-吡啶-2-基 | 0 |
F-0089 | H | H | H | H | H | 3-OMe-4-Cl-吡啶-2-基 | 0 |
F-0090 | H | H | H | H | H | 3-OMe-5-Cl-吡啶-2-基 | 0 |
F-0091 | H | H | H | H | H | 3-OMe-6-Cl-吡啶-2-基 | 0 |
F-0092 | H | H | H | H | H | 3-OMe-4-Me-吡啶-2-基 | 0 |
F-0093 | H | H | H | H | H | 3-OMe-5-Me-吡啶-2-基 | 0 |
F-0094 | H | H | H | H | H | 3-OMe-6-Me-吡啶-2-基 | 0 |
F-0095 | H | H | H | H | H | 3,4-(OMe)<sub>2</sub>-吡啶-2-基 | 0 |
F-0096 | H | H | H | H | H | 3,5-(OMe)<sub>2</sub>-吡啶-2-基 | 0 |
F-0097 | H | H | H | H | H | 3,6-(OMe)<sub>2</sub>-吡啶-2-基 | 0 |
F-0098 | H | H | H | H | H | 吡啶-3-基 | 0 |
F-0099 | H | H | H | H | H | 2-F-吡啶-3-基 | 0 |
F-0100 | H | H | H | H | H | 4-F-吡啶-3-基 | 0 |
F-0101 | H | H | H | H | H | 5-F-吡啶-3-基 | 0 |
F-0102 | H | H | H | H | H | 6-F-吡啶-3-基 | 0 |
F-0103 | H | H | H | H | H | 2-Cl-吡啶-3-基 | 0 |
F-0104 | H | H | H | H | H | 4-Cl-吡啶-3-基 | 0 |
F-0105 | H | H | H | H | H | 5-Cl-吡啶-3-基 | 0 |
F-0106 | H | H | H | H | H | 6-Cl-吡啶-3-基 | 0 |
F-0107 | H | H | H | H | H | 2-Me-吡啶-3-基 | 0 |
F-0108 | H | H | H | H | H | 4-Me-吡啶-3-基 | 0 |
F-0109 | H | H | H | H | H | 5-Me-吡啶-3-基 | 0 |
[表304]
化合物编号 | R1 | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-0110 | H | H | H | H | H | 6-Me-吡啶-3-基 | 0 |
F-0111 | H | H | H | H | H | 2-CF<sub>3</sub>-吡啶-3-基 | 0 |
F-0112 | H | H | H | H | H | 4-CF<sub>3</sub>-吡啶-3-基 | 0 |
F-0113 | H | H | H | H | H | 5-CF<sub>3</sub>-吡啶-3-基 | 0 |
F-0114 | H | H | H | H | H | 6-CF<sub>3</sub>-吡啶-3-基 | 0 |
F-0115 | H | H | H | H | H | 2-OMe-吡啶-3-基 | 0 |
F-0116 | H | H | H | H | H | 4-OMe-吡啶-3-基 | 0 |
F-0117 | H | H | H | H | H | 5-OMe-吡啶-3-基 | 0 |
F-0118 | H | H | H | H | H | 6-OMe-吡啶-3-基 | 0 |
F-0119 | H | H | H | H | H | 2,4-F<sub>2</sub>-吡啶-3-基 | 0 |
F-0120 | H | H | H | H | H | 2,5-F<sub>2</sub>-吡啶-3-基 | 0 |
F-0121 | H | H | H | H | H | 2,6-F<sub>2</sub>-吡啶-3-基 | 0 |
F-0122 | H | H | H | H | H | 4,5-F<sub>2</sub>-吡啶-3-基 | 0 |
F-0123 | H | H | H | H | H | 4,6-F<sub>2</sub>-吡啶-3-基 | 0 |
F-0124 | H | H | H | H | H | 2,4-Cl<sub>2</sub>-吡啶-3-基 | 0 |
F-0125 | H | H | H | H | H | 2,5-Cl<sub>2</sub>-吡啶-3-基 | 0 |
F-0126 | H | H | H | H | H | 2,6-Cl<sub>2</sub>-吡啶-3-基 | 0 |
F-0127 | H | H | H | H | H | 4,5-Cl<sub>2</sub>-吡啶-3-基 | 0 |
F-0128 | H | H | H | H | H | 4,6-Cl<sub>2</sub>-吡啶-3-基 | 0 |
F-0129 | H | H | H | H | H | 2-F-4-Cl-吡啶-3-基 | 0 |
F-0130 | H | H | H | H | H | 2-F-5-Cl-吡啶-3-基 | 0 |
F-0131 | H | H | H | H | H | 2-F-6-Cl-吡啶-3-基 | 0 |
F-0132 | H | H | H | H | H | 4-F-2-Cl-吡啶-3-基 | 0 |
F-0133 | H | H | H | H | H | 4-F-5-Cl-吡啶-3-基 | 0 |
F-0134 | H | H | H | H | H | 4-F-6-Cl-吡啶-3-基 | 0 |
F-0135 | H | H | H | H | H | 2-F-4-Me-吡啶-3-基 | 0 |
F-0136 | H | H | H | H | H | 2-F-5-Me-吡啶-3-基 | 0 |
F-0137 | H | H | H | H | H | 2-F-6-Me-吡啶-3-基 | 0 |
F-0138 | H | H | H | H | H | 4-F-2-Me-吡啶-3-基 | 0 |
F-0139 | H | H | H | H | H | 4-F-5-Me-吡啶-3-基 | 0 |
F-0140 | H | H | H | H | H | 4-F-6-Me-吡啶-3-基 | 0 |
F-0141 | H | H | H | H | H | 2-F-4-OMe-吡啶-3-基 | 0 |
F-0142 | H | H | H | H | H | 2-F-5-OMe-吡啶-3-基 | 0 |
F-0143 | H | H | H | H | H | 2-F-6-OMe-吡啶-3-基 | 0 |
F-0144 | H | H | H | H | H | 4-F-2-OMe-吡啶-3-基 | 0 |
F-0145 | H | H | H | H | H | 4-F-5-OMe-吡啶-3-基 | 0 |
F-0146 | H | H | H | H | H | 4-F-6-OMe-吡啶-3-基 | 0 |
F-0147 | H | H | H | H | H | 2-Cl-5-F-吡啶-3-基 | 0 |
F-0148 | H | H | H | H | H | 2-Cl-6-F-吡啶-3-基 | 0 |
F-0149 | H | H | H | H | H | 4-Cl-5-F-吡啶-3-基 | 0 |
F-0150 | H | H | H | H | H | 4-Cl-6-F-吡啶-3-基 | 0 |
F-0151 | H | H | H | H | H | 2-Cl-4-Me-吡啶-3-基 | 0 |
F-0152 | H | H | H | H | H | 2-Cl-5-Me-吡啶-3-基 | 0 |
F-0153 | H | H | H | H | H | 2-Cl-6-Me-吡啶-3-基 | 0 |
F-0154 | H | H | H | H | H | 4-Cl-2-Me-吡啶-3-基 | 0 |
F-0155 | H | H | H | H | H | 4-Cl-5-Me-吡啶-3-基 | 0 |
F-0156 | H | H | H | H | H | 4-Cl-6-Me-吡啶-3-基 | 0 |
F-0157 | H | H | H | H | H | 2-Me-5-F-吡啶-3-基 | 0 |
F-0158 | H | H | H | H | H | 2-Me-6-F-吡啶-3-基 | 0 |
F-0159 | H | H | H | H | H | 4-Me-5-F-吡啶-3-基 | 0 |
F-0160 | H | H | H | H | H | 4-Me-6-F-吡啶-3-基 | 0 |
F-0161 | H | H | H | H | H | 2-Me-5-Cl-吡啶-3-基 | 0 |
F-0162 | H | H | H | H | H | 2-Me-6-Cl-吡啶-3-基 | 0 |
F-0163 | H | H | H | H | H | 4-Me-5-Cl-吡啶-3-基 | 0 |
F-0164 | H | H | H | H | H | 4-Me-6-Cl-吡啶-3-基 | 0 |
F-0165 | H | H | H | H | H | 2,4-(Me)<sub>2</sub>-吡啶-3-基 | 0 |
F-0166 | H | H | H | H | H | 2,5-(Me)<sub>2</sub>-吡啶-3-基 | 0 |
[表305]
化合物编号 | R1 | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-0167 | H | H | H | H | H | 2,6-(Me)<sub>2</sub>-吡啶-3-基 | 0 |
F-0168 | H | H | H | H | H | 4,5-(Me)<sub>2</sub>-吡啶-3-基 | 0 |
F-0169 | H | H | H | H | H | 4,6-(Me)<sub>2</sub>-吡啶-3-基 | 0 |
F-0170 | H | H | H | H | H | 2-Me-4-OMe-吡啶-3-基 | 0 |
F-0171 | H | H | H | H | H | 2-Me-5-OMe-吡啶-3-基 | 0 |
F-0172 | H | H | H | H | H | 2-Me-6-OMe-吡啶-3-基 | 0 |
F-0173 | H | H | H | H | H | 4-Me-2-OMe-吡啶-3-基 | 0 |
F-0174 | H | H | H | H | H | 4-Me-5-OMe-吡啶-3-基 | 0 |
F-0175 | H | H | H | H | H | 4-Me-6-OMe-吡啶-3-基 | 0 |
F-0176 | H | H | H | H | H | 2-CF<sub>3</sub>-4-F-吡啶-3-基 | 0 |
F-0177 | H | H | H | H | H | 2-CF<sub>3</sub>-5-F-吡啶-3-基 | 0 |
F-0178 | H | H | H | H | H | 2-CF<sub>3</sub>-6-F-吡啶-3-基 | 0 |
F-0179 | H | H | H | H | H | 4-CF<sub>3</sub>-2-F-吡啶-3-基 | 0 |
F-0180 | H | H | H | H | H | 4-CF<sub>3</sub>-5-F-吡啶-3-基 | 0 |
F-0181 | H | H | H | H | H | 4-CF<sub>3</sub>-6-F-吡啶-3-基 | 0 |
F-0182 | H | H | H | H | H | 2-CF<sub>3</sub>-4-Me-吡啶-3-基 | 0 |
F-0183 | H | H | H | H | H | 2-CF<sub>3</sub>-5-Me-吡啶-3-基 | 0 |
F-0184 | H | H | H | H | H | 2-CF<sub>3</sub>-6-Me-吡啶-3-基 | 0 |
F-0185 | H | H | H | H | H | 4-CF<sub>3</sub>-2-Me-吡啶-3-基 | 0 |
F-0186 | H | H | H | H | H | 4-CF<sub>3</sub>-5-Me-吡啶-3-基 | 0 |
F-0187 | H | H | H | H | H | 4-CF<sub>3</sub>-6-Me-吡啶-3-基 | 0 |
F-0188 | H | H | H | H | H | 2-OMe-5-F-吡啶-3-基 | 0 |
F-0189 | H | H | H | H | H | 2-OMe-6-F-吡啶-3-基 | 0 |
F-0190 | H | H | H | H | H | 4-OMe-5-F-吡啶-3-基 | 0 |
F-0191 | H | H | H | H | H | 4-OMe-6-F-吡啶-3-基 | 0 |
F-0192 | H | H | H | H | H | 2-OMe-4-Cl-吡啶-3-基 | 0 |
F-0193 | H | H | H | H | H | 2-OMe-5-Cl-吡啶-3-基 | 0 |
F-0194 | H | H | H | H | H | 2-OMe-6-Cl-吡啶-3-基 | 0 |
F-0195 | H | H | H | H | H | 4-OMe-2-Cl-吡啶-3-基 | 0 |
F-0196 | H | H | H | H | H | 4-OMe-5-Cl-吡啶-3-基 | 0 |
F-0197 | H | H | H | H | H | 4-OMe-6-Cl-吡啶-3-基 | 0 |
F-0198 | H | H | H | H | H | 2-OMe-5-Me-吡啶-3-基 | 0 |
F-0199 | H | H | H | H | H | 2-OMe-6-Me-吡啶-3-基 | 0 |
F-0200 | H | H | H | H | H | 4-OMe-5-Me-吡啶-3-基 | 0 |
F-0201 | H | H | H | H | H | 4-OMe-6-Me-吡啶-3-基 | 0 |
F-0202 | H | H | H | H | H | 2,4-(OMe)<sub>2</sub>-吡啶-3-基 | 0 |
F-0203 | H | H | H | H | H | 2,5-(OMe)<sub>2</sub>-吡啶-3-基 | 0 |
F-0204 | H | H | H | H | H | 2,6-(OMe)<sub>2</sub>-吡啶-3-基 | 0 |
F-0205 | H | H | H | H | H | 4,5-(OMe)<sub>2</sub>-吡啶-3-基 | 0 |
F-0206 | H | H | H | H | H | 4,6-(OMe)<sub>2</sub>-吡啶-3-基 | 0 |
F-0207 | H | H | H | H | H | 吡啶-4-基 | 0 |
F-0208 | H | H | H | H | H | 2-F-吡啶-4-基 | 0 |
F-0209 | H | H | H | H | H | 3-F-吡啶-4-基 | 0 |
F-0210 | H | H | H | H | H | 2-Cl-吡啶-4-基 | 0 |
F-0211 | H | H | H | H | H | 3-Cl-吡啶-4-基 | 0 |
F-0212 | H | H | H | H | H | 2-Me-吡啶-4-基 | 0 |
F-0213 | H | H | H | H | H | 3-Me-吡啶-4-基 | 0 |
F-0214 | H | H | H | H | H | 2-CF<sub>3</sub>-吡啶-4-基 | 0 |
F-0215 | H | H | H | H | H | 3-CF<sub>3</sub>-吡啶-4-基 | 0 |
F-0216 | H | H | H | H | H | 2-OMe-吡啶-4-基 | 0 |
F-0217 | H | H | H | H | H | 3-OMe-吡啶-4-基 | 0 |
F-0218 | H | H | H | H | H | 2,3-F<sub>2</sub>-吡啶-4-基 | 0 |
F-0219 | H | H | H | H | H | 2,5-F<sub>2</sub>-吡啶-4-基 | 0 |
F-0220 | H | H | H | H | H | 2,6-F<sub>2</sub>-吡啶-4-基 | 0 |
F-0221 | H | H | H | H | H | 3,5-F<sub>2</sub>-吡啶-4-基 | 0 |
F-0222 | H | H | H | H | H | 2,3-Cl<sub>2</sub>-吡啶-4-基 | 0 |
F-0223 | H | H | H | H | H | 2,5-Cl<sub>2</sub>-吡啶-4-基 | 0 |
[表306]
化合物编号 | R1 | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-0224 | H | H | H | H | H | 2,6-Cl<sub>2</sub>-吡啶-4-基 | 0 |
F-0225 | H | H | H | H | H | 3,5-Cl<sub>2</sub>-吡啶-4-基 | 0 |
F-0226 | H | H | H | H | H | 3-F-2-Cl-吡啶-4-基 | 0 |
F-0227 | H | H | H | H | H | 3-F-5-Cl-吡啶-4-基 | 0 |
F-0228 | H | H | H | H | H | 3-F-6-Cl-吡啶-4-基 | 0 |
F-0229 | H | H | H | H | H | 3-F-2-Me-吡啶-4-基 | 0 |
F-0230 | H | H | H | H | H | 3-F-5-Me-吡啶-4-基 | 0 |
F-0231 | H | H | H | H | H | 3-F-6-Me-吡啶-4-基 | 0 |
F-0232 | H | H | H | H | H | 3-F-2-OMe-吡啶-4-基 | 0 |
F-0233 | H | H | H | H | H | 3-F-5-OMe-吡啶-4-基 | 0 |
F-0234 | H | H | H | H | H | 3-F-6-OMe-吡啶-4-基 | 0 |
F-0235 | H | H | H | H | H | 3-Cl-2-F-吡啶-4-基 | 0 |
F-0236 | H | H | H | H | H | 3-Cl-6-F-吡啶-4-基 | 0 |
F-0237 | H | H | H | H | H | 3-Cl-2-Me-吡啶-4-基 | 0 |
F-0238 | H | H | H | H | H | 3-Cl-5-Me-吡啶-4-基 | 0 |
F-0239 | H | H | H | H | H | 3-Cl-6-Me-吡啶-4-基 | 0 |
F-0240 | H | H | H | H | H | 3-Me-2-F-吡啶-4-基 | 0 |
F-0241 | H | H | H | H | H | 3-Me-6-F-吡啶-4-基 | 0 |
F-0242 | H | H | H | H | H | 3-Me-2-Cl-吡啶-4-基 | 0 |
F-0243 | H | H | H | H | H | 3-Me-6-Cl-吡啶-4-基 | 0 |
F-0244 | H | H | H | H | H | 2,3-(Me)<sub>2</sub>-吡啶-4-基 | 0 |
F-0245 | H | H | H | H | H | 3,5-(Me)<sub>2</sub>-吡啶-4-基 | 0 |
F-0246 | H | H | H | H | H | 3,6-(Me)<sub>2</sub>-吡啶-4-基 | 0 |
F-0247 | H | H | H | H | H | 3-Me-2-OMe-吡啶-4-基 | 0 |
F-0248 | H | H | H | H | H | 3-Me-5-OMe-吡啶-4-基 | 0 |
F-0249 | H | H | H | H | H | 3-Me-6-OMe-吡啶-4-基 | 0 |
F-0250 | H | H | H | H | H | 3-CF<sub>3</sub>-2-F-吡啶-4-基 | 0 |
F-0251 | H | H | H | H | H | 3-CF<sub>3</sub>-5-F-吡啶-4-基 | 0 |
F-0252 | H | H | H | H | H | 3-CF<sub>3</sub>-6-F-吡啶-4-基 | 0 |
F-0253 | H | H | H | H | H | 3-CF<sub>3</sub>-2-Me-吡啶-4-基 | 0 |
F-0254 | H | H | H | H | H | 3-CF<sub>3</sub>-5-Me-吡啶-4-基 | 0 |
F-0255 | H | H | H | H | H | 3-CF<sub>3</sub>-6-Me-吡啶-4-基 | 0 |
F-0256 | H | H | H | H | H | 3-OMe-2-F-吡啶-4-基 | 0 |
F-0257 | H | H | H | H | H | 3-OMe-6-F-吡啶-4-基 | 0 |
F-0258 | H | H | H | H | H | 3-OMe-2-Cl-吡啶-4-基 | 0 |
F-0259 | H | H | H | H | H | 3-OMe-5-Cl-吡啶-4-基 | 0 |
F-0260 | H | H | H | H | H | 3-OMe-6-Cl-吡啶-4-基 | 0 |
F-0261 | H | H | H | H | H | 3-OMe-2-Me-吡啶-4-基 | 0 |
F-0262 | H | H | H | H | H | 3-OMe-6-Me-吡啶-4-基 | 0 |
F-0263 | H | H | H | H | H | 2,3-(OMe)<sub>2</sub>-吡啶-4-基 | 0 |
F-0264 | H | H | H | H | H | 3,5-(OMe)<sub>2</sub>-吡啶-4-基 | 0 |
F-0265 | H | H | H | H | H | 3,6-(OMe)<sub>2</sub>-吡啶-4-基 | 0 |
F-0266 | H | H | H | H | H | 嘧啶-2-基 | 0 |
F-0267 | H | H | H | H | H | 嘧啶-4-基 | 0 |
F-0268 | H | H | H | H | H | 5-F-嘧啶-4-基 | 0 |
F-0269 | H | H | H | H | H | 5-Me-嘧啶-4-基 | 0 |
F-0270 | H | H | H | H | H | 5-CF<sub>3</sub>-嘧啶-4-基 | 0 |
F-0271 | H | H | H | H | H | 5-OMe-嘧啶-4-基 | 0 |
F-0272 | H | H | H | H | H | 嘧啶-5-基 | 0 |
F-0273 | H | H | H | H | H | 4-F-嘧啶-5-基 | 0 |
F-0274 | H | H | H | H | H | 4-Cl-嘧啶-5-基 | 0 |
F-0275 | H | H | H | H | H | 4-Me-嘧啶-5-基 | 0 |
F-0276 | H | H | H | H | H | 4-CF<sub>3</sub>-嘧啶-5-基 | 0 |
F-0277 | H | H | H | H | H | 4-OMe-嘧啶-5-基 | 0 |
F-0278 | H | H | H | H | H | 哒嗪-3-基 | 0 |
F-0279 | H | H | H | H | H | 4-F-哒嗪-3-基 | 0 |
F-0280 | H | H | H | H | H | 4-Cl-哒嗪-3-基 | 0 |
[表307]
化合物编号 | R1 | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-0281 | H | H | H | H | H | 4-Me-哒嗪-3-基 | 0 |
F-0282 | H | H | H | H | H | 4-CF<sub>3</sub>-哒嗪-3-基 | 0 |
F-0283 | H | H | H | H | H | 4-OMe-哒嗪-3-基 | 0 |
F-0284 | H | H | H | H | H | 哒嗪-4-基 | 0 |
F-0285 | H | H | H | H | H | 3-F-哒嗪-4-基 | 0 |
F-0286 | H | H | H | H | H | 3-Cl-哒嗪-4-基 | 0 |
F-0287 | H | H | H | H | H | 3-Me-哒嗪-4-基 | 0 |
F-0288 | H | H | H | H | H | 3-CF<sub>3</sub>-哒嗪-4-基 | 0 |
F-0289 | H | H | H | H | H | 3-OMe-哒嗪-4-基 | 0 |
F-0290 | H | H | H | H | H | 5-F-哒嗪-4-基 | 0 |
F-0291 | H | H | H | H | H | 5-Cl-哒嗪-4-基 | 0 |
F-0292 | H | H | H | H | H | 5-Me-哒嗪-4-基 | 0 |
F-0293 | H | H | H | H | H | 5-CF<sub>3</sub>-哒嗪-4-基 | 0 |
F-0294 | H | H | H | H | H | 5-OMe-哒嗪-4-基 | 0 |
F-0295 | H | H | H | H | H | 噻吩-2-基 | 0 |
F-0296 | H | H | H | H | H | 3-F-噻吩-2-基 | 0 |
F-0297 | H | H | H | H | H | 3-Cl-噻吩-2-基 | 0 |
F-0298 | H | H | H | H | H | 3-Me-噻吩-2-基 | 0 |
F-0299 | H | H | H | H | H | 3-CF<sub>3</sub>-噻吩-2-基 | 0 |
F-0300 | H | H | H | H | H | 3-OMe-噻吩-2-基 | 0 |
F-0301 | H | H | H | H | H | 噻吩-3-基 | 0 |
F-0302 | H | H | H | H | H | 2-F-噻吩-3-基 | 0 |
F-0303 | H | H | H | H | H | 2-Cl-噻吩-3-基 | 0 |
F-0304 | H | H | H | H | H | 2-Me-噻吩-3-基 | 0 |
F-0305 | H | H | H | H | H | 2-CF<sub>3</sub>-噻吩-3-基 | 0 |
F-0306 | H | H | H | H | H | 2-OMe-噻吩-3-基 | 0 |
F-0307 | H | H | H | H | H | 4-F-噻吩-3-基 | 0 |
F-0308 | H | H | H | H | H | 4-Cl-噻吩-3-基 | 0 |
F-0309 | H | H | H | H | H | 4-Me-噻吩-3-基 | 0 |
F-0310 | H | H | H | H | H | 4-CF<sub>3</sub>-噻吩-3-基 | 0 |
F-0311 | H | H | H | H | H | 4-OMe-噻吩-3-基 | 0 |
F-0312 | H | H | H | H | H | 噻唑-2-基 | 0 |
F-0313 | H | H | H | H | H | 噻唑-4-基 | 0 |
F-0314 | H | H | H | H | H | 5-F-噻唑-4-基 | 0 |
F-0315 | H | H | H | H | H | 5-Me-噻唑-4-基 | 0 |
F-0316 | H | H | H | H | H | 5-CF<sub>3</sub>-噻唑-4-基 | 0 |
F-0317 | H | H | H | H | H | 5-OMe-噻唑-4-基 | 0 |
F-0318 | H | H | H | H | H | 噻唑-5-基 | 0 |
F-0319 | H | H | H | H | H | 4-F-噻唑-5-基 | 0 |
F-0320 | H | H | H | H | H | 4-Me-噻唑-5-基 | 0 |
F-0321 | H | H | H | H | H | 4-CF<sub>3</sub>-噻唑-5-基 | 0 |
F-0322 | H | H | H | H | H | 4-OMe-噻唑-5-基 | 0 |
F-0323 | H | H | H | H | H | 1H-吡咯-1-基 | 0 |
F-0324 | H | H | H | H | H | 2-F-1H-吡咯-1-基 | 0 |
F-0325 | H | H | H | H | H | 2-Me-1H-吡咯-1-基 | 0 |
F-0326 | H | H | H | H | H | 2-CF<sub>3</sub>-1H-吡咯-1-基 | 0 |
F-0327 | H | H | H | H | H | 2-OMe-1H-吡咯-1-基 | 0 |
F-0328 | H | H | H | H | H | 1H-吡咯-2-基 | 0 |
F-0329 | H | H | H | H | H | 1-Me-1H-吡咯-2-基 | 0 |
F-0330 | H | H | H | H | H | 3-F-1H-吡咯-2-基 | 0 |
F-0331 | H | H | H | H | H | 3-Me-1H-吡咯-2-基 | 0 |
F-0332 | H | H | H | H | H | 3-CF<sub>3</sub>-1H-吡咯-2-基 | 0 |
F-0333 | H | H | H | H | H | 3-OMe-1H-吡咯-2-基 | 0 |
F-0334 | H | H | H | H | H | 1-Me-3-F-1H-吡咯-2-基 | 0 |
F-0335 | H | H | H | H | H | 1,3-(Me)<sub>2</sub>-1H-吡咯-2-基 | 0 |
F-0336 | H | H | H | H | H | 1-Me-3-CF<sub>3</sub>-1H-吡咯-2-基 | 0 |
F-0337 | H | H | H | H | H | 1-Me-3-OMe-1H-吡咯-2-基 | 0 |
[表308]
化合物编号 | R1 | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-0338 | H | H | H | H | H | 1H-吡咯-3-基 | 0 |
F-0339 | H | H | H | H | H | 1-Me-1H-吡咯-3-基 | 0 |
F-0340 | H | H | H | H | H | 2-F-1H-吡咯-3-基 | 0 |
F-0341 | H | H | H | H | H | 2-Me-1H-吡咯-3-基 | 0 |
F-0342 | H | H | H | H | H | 2-CF<sub>3</sub>-1H-吡咯-3-基 | 0 |
F-0343 | H | H | H | H | H | 2-OMe-1H-吡咯-3-基 | 0 |
F-0344 | H | H | H | H | H | 1-Me-2-F-1H-吡咯-3-基 | 0 |
F-0345 | H | H | H | H | H | 1,2-(Me)<sub>2</sub>-1H-吡咯-3-基 | 0 |
F-0346 | H | H | H | H | H | 1-Me-2-CF<sub>3</sub>-1H-吡咯-3-基 | 0 |
F-0347 | H | H | H | H | H | 1-Me-2-OMe-1H-吡咯-3-基 | 0 |
F-0348 | H | H | H | H | H | 4-F-1H-吡咯-3-基 | 0 |
F-0349 | H | H | H | H | H | 4-Me-1H-吡咯-3-基 | 0 |
F-0350 | H | H | H | H | H | 4-CF<sub>3</sub>-1H-吡咯-3-基 | 0 |
F-0351 | H | H | H | H | H | 4-OMe-1H-吡咯-3-基 | 0 |
F-0352 | H | H | H | H | H | 1-Me-4-F-1H-吡咯-3-基 | 0 |
F-0353 | H | H | H | H | H | 1,4-(Me)<sub>2</sub>-1H-吡咯-3-基 | 0 |
F-0354 | H | H | H | H | H | 1-Me-4-CF<sub>3</sub>-1H-吡咯-3-基 | 0 |
F-0355 | H | H | H | H | H | 1-Me-4-OMe-1H-吡咯-3-基 | 0 |
F-0356 | H | H | H | H | H | 1H-吡唑-1-基 | 0 |
F-0357 | H | H | H | H | H | 5-F-1H-吡唑-1-基 | 0 |
F-0358 | H | H | H | H | H | 5-Cl-1H-吡唑-1-基 | 0 |
F-0359 | H | H | H | H | H | 5-Me-1H-吡唑-1-基 | 0 |
F-0360 | H | H | H | H | H | 5-CF<sub>3</sub>-1H-吡唑-1-基 | 0 |
F-0361 | H | H | H | H | H | 5-OMe-1H-吡唑-1-基 | 0 |
F-0362 | H | H | H | H | H | 1H-吡唑-3-基 | 0 |
F-0363 | H | H | H | H | H | 1-Me-1H-吡唑-3-基 | 0 |
F-0364 | H | H | H | H | H | 4-F-1H-吡唑-3-基 | 0 |
F-0365 | H | H | H | H | H | 4-Cl-1H-吡唑-3-基 | 0 |
F-0366 | H | H | H | H | H | 4-Me-1H-吡唑-3-基 | 0 |
F-0367 | H | H | H | H | H | 4-CF<sub>3</sub>-1H-吡唑-3-基 | 0 |
F-0368 | H | H | H | H | H | 4-OMe-1H-吡唑-3-基 | 0 |
F-0369 | H | H | H | H | H | 1-Me-4-F-1H-吡唑-3-基 | 0 |
F-0370 | H | H | H | H | H | 1-Me-4-Cl-1H-吡唑-3-基 | 0 |
F-0371 | H | H | H | H | H | 1,4-(Me)<sub>2</sub>-1H-吡唑-3-基 | 0 |
F-0372 | H | H | H | H | H | 1-Me-4-CF<sub>3</sub>-1H-吡唑-3-基 | 0 |
F-0373 | H | H | H | H | H | 1-Me-4-OMe-1H-吡唑-3-基 | 0 |
F-0374 | H | H | H | H | H | 1H-吡唑-4-基 | 0 |
F-0375 | H | H | H | H | H | 1-Me-1H-吡唑-4-基 | 0 |
F-0376 | H | H | H | H | H | 3-F-1H-吡唑-4-基 | 0 |
F-0377 | H | H | H | H | H | 3-Cl-1H-吡唑-4-基 | 0 |
F-0378 | H | H | H | H | H | 3-Me-1H-吡唑-4-基 | 0 |
F-0379 | H | H | H | H | H | 3-CF<sub>3</sub>-1H-吡唑-4-基 | 0 |
F-0380 | H | H | H | H | H | 3-OMe-1H-吡唑-4-基 | 0 |
F-0381 | H | H | H | H | H | 1-Me-3-F-1H-吡唑-4-基 | 0 |
F-0382 | H | H | H | H | H | 1-Me-3-Cl-1H-吡唑-4-基 | 0 |
F-0383 | H | H | H | H | H | 1,3-(Me)<sub>2</sub>-1H-吡唑-4-基 | 0 |
F-0384 | H | H | H | H | H | 1-Me-3-CF<sub>3</sub>-1H-吡唑-4-基 | 0 |
F-0385 | H | H | H | H | H | 1-Me-3-OMe-1H-吡唑-4-基 | 0 |
F-0386 | H | H | H | H | H | 5-F-1H-吡唑-4-基 | 0 |
F-0387 | H | H | H | H | H | 5-Cl-1H-吡唑-4-基 | 0 |
F-0388 | H | H | H | H | H | 5-Me-1H-吡唑-4-基 | 0 |
F-0389 | H | H | H | H | H | 5-CF<sub>3</sub>-1H-吡唑-4-基 | 0 |
F-0390 | H | H | H | H | H | 5-OMe-1H-吡唑-4-基 | 0 |
F-0391 | H | H | H | H | H | 1-Me-5-F-1H-吡唑-4-基 | 0 |
F-0392 | H | H | H | H | H | 1-Me-5-Cl-1H-吡唑-4-基 | 0 |
F-0393 | H | H | H | H | H | 1,5-(Me)<sub>2</sub>-1H-吡唑-4-基 | 0 |
F-0394 | H | H | H | H | H | 1-Me-5-CF<sub>3</sub>-1H-吡唑-4-基 | 0 |
[表309]
[表310]
[表311]
[表312]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-5053 | H | H | H | H | H | 3-F-4-Cl-吡啶-2-基 | 1 |
F-5054 | H | H | H | H | H | 3-F-5-Cl-吡啶-2-基 | 1 |
F-5055 | H | H | H | H | H | 3-F-6-Cl-吡啶-2-基 | 1 |
F-5056 | H | H | H | H | H | 3-F-4-Me-吡啶-2-基 | 1 |
F-5057 | H | H | H | H | H | 3-F-5-Me-吡啶-2-基 | 1 |
F-5058 | H | H | H | H | H | 3-F-6-Me-吡啶-2-基 | 1 |
F-5059 | H | H | H | H | H | 3-F-4-OMe-吡啶-2-基 | 1 |
F-5060 | H | H | H | H | H | 3-F-5-OMe-吡啶-2-基 | 1 |
F-5061 | H | H | H | H | H | 3-F-6-OMe-吡啶-2-基 | 1 |
F-5062 | H | H | H | H | H | 3-Cl-4-F-吡啶-2-基 | 1 |
F-5063 | H | H | H | H | H | 3-Cl-5-F-吡啶-2-基 | 1 |
F-5064 | H | H | H | H | H | 3-Cl-6-F-吡啶-2-基 | 1 |
F-5065 | H | H | H | H | H | 3-Cl-4-Me-吡啶-2-基 | 1 |
F-5066 | H | H | H | H | H | 3-Cl-5-Me-吡啶-2-基 | 1 |
F-5067 | H | H | H | H | H | 3-Cl-6-Me-吡啶-2-基 | 1 |
F-5068 | H | H | H | H | H | 3-Me-4-F-吡啶-2-基 | 1 |
F-5069 | H | H | H | H | H | 3-Me-5-F-吡啶-2-基 | 1 |
F-5070 | H | H | H | H | H | 3-Me-6-F-吡啶-2-基 | 1 |
F-5071 | H | H | H | H | H | 3-Me-4-Cl-吡啶-2-基 | 1 |
F-5072 | H | H | H | H | H | 3-Me-5-Cl-吡啶-2-基 | 1 |
F-5073 | H | H | H | H | H | 3-Me-6-Cl-吡啶-2-基 | 1 |
F-5074 | H | H | H | H | H | 3,4-(Me)<sub>2</sub>-吡啶-2-基 | 1 |
F-5075 | H | H | H | H | H | 3,5-(Me)<sub>2</sub>-吡啶-2-基 | 1 |
F-5076 | H | H | H | H | H | 3,6-(Me)<sub>2</sub>-吡啶-2-基 | 1 |
F-5077 | H | H | H | H | H | 3-Me-4-OMe-吡啶-2-基 | 1 |
F-5078 | H | H | H | H | H | 3-Me-5-OMe-吡啶-2-基 | 1 |
F-5079 | H | H | H | H | H | 3-Me-6-OMe-吡啶-2-基 | 1 |
F-5080 | H | H | H | H | H | 3-CF3-4-F-吡啶-2-基 | 1 |
F-5081 | H | H | H | H | H | 3-CF3-5-F-吡啶-2-基 | 1 |
F-5082 | H | H | H | H | H | 3-CF3-6-F-吡啶-2-基 | 1 |
F-5083 | H | H | H | H | H | 3-CF3-4-Me-吡啶-2-基 | 1 |
F-5084 | H | H | H | H | H | 3-CF3-5-Me-吡啶-2-基 | 1 |
F-5085 | H | H | H | H | H | 3-CF3-6-Me-吡啶-2-基 | 1 |
F-5086 | H | H | H | H | H | 3-OMe-4-F-吡啶-2-基 | 1 |
F-5087 | H | H | H | H | H | 3-OMe-5-F-吡啶-2-基 | 1 |
F-5088 | H | H | H | H | H | 3-OMe-6-F-吡啶-2-基 | 1 |
F-5089 | H | H | H | H | H | 3-OMe-4-Cl-吡啶-2-基 | 1 |
F-5090 | H | H | H | H | H | 3-OMe-5-Cl-吡啶-2-基 | 1 |
F-5091 | H | H | H | H | H | 3-OMe-6-Cl-吡啶-2-基 | 1 |
F-5092 | H | H | H | H | H | 3-OMe-4-Me-吡啶-2-基 | 1 |
F-5093 | H | H | H | H | H | 3-OMe-5-Me-吡啶-2-基 | 1 |
F-5094 | H | H | H | H | H | 3-OMe-6-Me-吡啶-2-基 | 1 |
F-5095 | H | H | H | H | H | 3,4-(OMe)<sub>2</sub>-吡啶-2-基 | 1 |
F-5096 | H | H | H | H | H | 3,5-(OMe)<sub>2</sub>-吡啶-2-基 | 1 |
F-5097 | H | H | H | H | H | 3,6-(OMe)<sub>2</sub>-吡啶-2-基 | 1 |
F-5098 | H | H | H | H | H | 吡啶-3-基 | 1 |
F-5099 | H | H | H | H | H | 2-F-吡啶-3-基 | 1 |
F-5100 | H | H | H | H | H | 4-F-吡啶-3-基 | 1 |
F-5101 | H | H | H | H | H | 5-F-吡啶-3-基 | 1 |
F-5102 | H | H | H | H | H | 6-F-吡啶-3-基 | 1 |
F-5103 | H | H | H | H | H | 2-Cl-吡啶-3-基 | 1 |
F-5104 | H | H | H | H | H | 4-Cl-吡啶-3-基 | 1 |
F-5105 | H | H | H | H | H | 5-Cl-吡啶-3-基 | 1 |
F-5106 | H | H | H | H | H | 6-Cl-吡啶-3-基 | 1 |
F-5107 | H | H | H | H | H | 2-Me-吡啶-3-基 | 1 |
F-5108 | H | H | H | H | H | 4-Me-吡啶-3-基 | 1 |
F-5109 | H | H | H | H | H | 5-Me-吡啶-3-基 | 1 |
[表313]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-5110 | H | H | H | H | H | 6-Me-吡啶-3-基 | 1 |
F-5111 | H | H | H | H | H | 2-CF<sub>3</sub>-吡啶-3-基 | 1 |
F-5112 | H | H | H | H | H | 4-CF<sub>3</sub>-吡啶-3-基 | 1 |
F-5113 | H | H | H | H | H | 5-CF<sub>3</sub>-吡啶-3-基 | 1 |
F-5114 | H | H | H | H | H | 6-CF<sub>3</sub>-吡啶-3-基 | 1 |
F-5115 | H | H | H | H | H | 2-OMe-吡啶-3-基 | 1 |
F-5116 | H | H | H | H | H | 4-OMe-吡啶-3-基 | 1 |
F-5117 | H | H | H | H | H | 5-OMe-吡啶-3-基 | 1 |
F-5118 | H | H | H | H | H | 6-OMe-吡啶-3-基 | 1 |
F-5119 | H | H | H | H | H | 2,4-F<sub>2</sub>-吡啶-3-基 | 1 |
F-5120 | H | H | H | H | H | 2,5-F<sub>2</sub>-吡啶-3-基 | 1 |
F-5121 | H | H | H | H | H | 2,6-F<sub>2</sub>-吡啶-3-基 | 1 |
F-5122 | H | H | H | H | H | 4,5-F<sub>2</sub>-吡啶-3-基 | 1 |
F-5123 | H | H | H | H | H | 4,6-F<sub>2</sub>-吡啶-3-基 | 1 |
F-5124 | H | H | H | H | H | 2,4-Cl<sub>2</sub>-吡啶-3-基 | 1 |
F-5125 | H | H | H | H | H | 2,5-Cl<sub>2</sub>-吡啶-3-基 | 1 |
F-5126 | H | H | H | H | H | 2,6-Cl<sub>2</sub>-吡啶-3-基 | 1 |
F-5127 | H | H | H | H | H | 4,5-Cl<sub>2</sub>-吡啶-3-基 | 1 |
F-5128 | H | H | H | H | H | 4,6-Cl<sub>2</sub>-吡啶-3-基 | 1 |
F-5129 | H | H | H | H | H | 2-F-4-Cl-吡啶-3-基 | 1 |
F-5130 | H | H | H | H | H | 2-F-5-Cl-吡啶-3-基 | 1 |
F-5131 | H | H | H | H | H | 2-F-6-Cl-吡啶-3-基 | 1 |
F-5132 | H | H | H | H | H | 4-F-2-Cl-吡啶-3-基 | 1 |
F-5133 | H | H | H | H | H | 4-F-5-Cl-吡啶-3-基 | 1 |
F-5134 | H | H | H | H | H | 4-F-6-Cl-吡啶-3-基 | 1 |
F-5135 | H | H | H | H | H | 2-F-4-Me-吡啶-3-基 | 1 |
F-5136 | H | H | H | H | H | 2-F-5-Me-吡啶-3-基 | 1 |
F-5137 | H | H | H | H | H | 2-F-6-Me-吡啶-3-基 | 1 |
F-5138 | H | H | H | H | H | 4-F-2-Me-吡啶-3-基 | 1 |
F-5139 | H | H | H | H | H | 4-F-5-Me-吡啶-3-基 | 1 |
F-5140 | H | H | H | H | H | 4-F-6-Me-吡啶-3-基 | 1 |
F-5141 | H | H | H | H | H | 2-F-4-OMe-吡啶-3-基 | 1 |
F-5142 | H | H | H | H | H | 2-F-5-OMe-吡啶-3-基 | 1 |
F-5143 | H | H | H | H | H | 2-F-6-OMe-吡啶-3-基 | 1 |
F-5144 | H | H | H | H | H | 4-F-2-OMe-吡啶-3-基 | 1 |
F-5145 | H | H | H | H | H | 4-F-5-OMe-吡啶-3-基 | 1 |
F-5146 | H | H | H | H | H | 4-F-6-OMe-吡啶-3-基 | 1 |
F-5147 | H | H | H | H | H | 2-Cl-5-F-吡啶-3-基 | 1 |
F-5148 | H | H | H | H | H | 2-Cl-6-F-吡啶-3-基 | 1 |
F-5149 | H | H | H | H | H | 4-Cl-5-F-吡啶-3-基 | 1 |
F-5150 | H | H | H | H | H | 4-Cl-6-F-吡啶-3-基 | 1 |
F-5151 | H | H | H | H | H | 2-Cl-4-Me-吡啶-3-基 | 1 |
F-5152 | H | H | H | H | H | 2-Cl-5-Me-吡啶-3-基 | 1 |
F-5153 | H | H | H | H | H | 2-Cl-6-Me-吡啶-3-基 | 1 |
F-5154 | H | H | H | H | H | 4-Cl-2-Me-吡啶-3-基 | 1 |
F-5155 | H | H | H | H | H | 4-Cl-5-Me-吡啶-3-基 | 1 |
F-5156 | H | H | H | H | H | 4-Cl-6-Me-吡啶-3-基 | 1 |
F-5157 | H | H | H | H | H | 2-Me-5-F-吡啶-3-基 | 1 |
F-5158 | H | H | H | H | H | 2-Me-6-F-吡啶-3-基 | 1 |
F-5159 | H | H | H | H | H | 4-Me-5-F-吡啶-3-基 | 1 |
F-5160 | H | H | H | H | H | 4-Me-6-F-吡啶-3-基 | 1 |
F-5161 | H | H | H | H | H | 2-Me-5-Cl-吡啶-3-基 | 1 |
F-5162 | H | H | H | H | H | 2-Me-6-Cl-吡啶-3-基 | 1 |
F-5163 | H | H | H | H | H | 4-Me-5-Cl-吡啶-3-基 | 1 |
F-5164 | H | H | H | H | H | 4-Me-6-Cl-吡啶-3-基 | 1 |
F-5165 | H | H | H | H | H | 2,4-(Me)<sub>2</sub>-吡啶-3-基 | 1 |
F-5166 | H | H | H | H | H | 2,5-(Me)<sub>2</sub>-吡啶-3-基 | 1 |
[表314]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-5167 | H | H | H | H | H | 2,6-(Me)<sub>2</sub>-吡啶-3-基 | 1 |
F-5168 | H | H | H | H | H | 4,5-(Me)<sub>2</sub>-吡啶-3-基 | 1 |
F-5169 | H | H | H | H | H | 4,6-(Me)<sub>2</sub>-吡啶-3-基 | 1 |
F-5170 | H | H | H | H | H | 2-Me-4-OMe-吡啶-3-基 | 1 |
F-5171 | H | H | H | H | H | 2-Me-5-OMe-吡啶-3-基 | 1 |
F-5172 | H | H | H | H | H | 2-Me-6-OMe-吡啶-3-基 | 1 |
F-5173 | H | H | H | H | H | 4-Me-2-OMe-吡啶-3-基 | 1 |
F-5174 | H | H | H | H | H | 4-Me-5-OMe-吡啶-3-基 | 1 |
F-5175 | H | H | H | H | H | 4-Me-6-OMe-吡啶-3-基 | 1 |
F-5176 | H | H | H | H | H | 2-CF<sub>3</sub>-4-F-吡啶-3-基 | 1 |
F-5177 | H | H | H | H | H | 2-CF<sub>3</sub>-5-F-吡啶-3-基 | 1 |
F-5178 | H | H | H | H | H | 2-CF<sub>3</sub>-6-F-吡啶-3-基 | 1 |
F-5179 | H | H | H | H | H | 4-CF<sub>3</sub>-2-F-吡啶-3-基 | 1 |
F-5180 | H | H | H | H | H | 4-CF<sub>3</sub>-5-F-吡啶-3-基 | 1 |
F-5181 | H | H | H | H | H | 4-CF<sub>3</sub>-6-F-吡啶-3-基 | 1 |
F-5182 | H | H | H | H | H | 2-CF<sub>3</sub>-4-Me-吡啶-3-基 | 1 |
F-5183 | H | H | H | H | H | 2-CF<sub>3</sub>-5-Me-吡啶-3-基 | 1 |
F-5184 | H | H | H | H | H | 2-CF<sub>3</sub>-6-Me-吡啶-3-基 | 1 |
F-5185 | H | H | H | H | H | 4-CF<sub>3</sub>-2-Me-吡啶-3-基 | 1 |
F-5186 | H | H | H | H | H | 4-CF<sub>3</sub>-5-Me-吡啶-3-基 | 1 |
F-5187 | H | H | H | H | H | 4-CF<sub>3</sub>-6-Me-吡啶-3-基 | 1 |
F-5188 | H | H | H | H | H | 2-OMe-5-F-吡啶-3-基 | 1 |
F-5189 | H | H | H | H | H | 2-OMe-6-F-吡啶-3-基 | 1 |
F-5190 | H | H | H | H | H | 4-OMe-5-F-吡啶-3-基 | 1 |
F-5191 | H | H | H | H | H | 4-OMe-6-F-吡啶-3-基 | 1 |
F-5192 | H | H | H | H | H | 2-OMe-4-Cl-吡啶-3-基 | 1 |
F-5193 | H | H | H | H | H | 2-OMe-5-Cl-吡啶-3-基 | 1 |
F-5194 | H | H | H | H | H | 2-OMe-6-Cl-吡啶-3-基 | 1 |
F-5195 | H | H | H | H | H | 4-OMe-2-Cl-吡啶-3-基 | 1 |
F-5196 | H | H | H | H | H | 4-OMe-5-Cl-吡啶-3-基 | 1 |
F-5197 | H | H | H | H | H | 4-OMe-6-Cl-吡啶-3-基 | 1 |
F-5198 | H | H | H | H | H | 2-OMe-5-Me-吡啶-3-基 | 1 |
F-5199 | H | H | H | H | H | 2-OMe-6-Me-吡啶-3-基 | 1 |
F-5200 | H | H | H | H | H | 4-OMe-5-Me-吡啶-3-基 | 1 |
F-5201 | H | H | H | H | H | 4-OMe-6-Me-吡啶-3-基 | 1 |
F-5202 | H | H | H | H | H | 2,4-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
F-5203 | H | H | H | H | H | 2,5-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
F-5204 | H | H | H | H | H | 2,6-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
F-5205 | H | H | H | H | H | 4,5-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
F-5206 | H | H | H | H | H | 4,6-(OMe)<sub>2</sub>-吡啶-3-基 | 1 |
F-5207 | H | H | H | H | H | 吡啶-4-基 | 1 |
F-5208 | H | H | H | H | H | 2-F-吡啶-4-基 | 1 |
F-5209 | H | H | H | H | H | 3-F-吡啶-4-基 | 1 |
F-5210 | H | H | H | H | H | 2-Cl-吡啶-4-基 | 1 |
F-5211 | H | H | H | H | H | 3-Cl-吡啶-4-基 | 1 |
F-5212 | H | H | H | H | H | 2-Me-吡啶-4-基 | 1 |
F-5213 | H | H | H | H | H | 3-Me-吡啶-4-基 | 1 |
F-5214 | H | H | H | H | H | 2-CF<sub>3</sub>-吡啶-4-基 | 1 |
F-5215 | H | H | H | H | H | 3-CF<sub>3</sub>-吡啶-4-基 | 1 |
F-5216 | H | H | H | H | H | 2-OMe-吡啶-4-基 | 1 |
F-5217 | H | H | H | H | H | 3-OMe-吡啶-4-基 | 1 |
F-5218 | H | H | H | H | H | 2,3-F<sub>2</sub>-吡啶-4-基 | 1 |
F-5219 | H | H | H | H | H | 2,5-F<sub>2</sub>-吡啶-4-基 | 1 |
F-5220 | H | H | H | H | H | 2,6-F<sub>2</sub>-吡啶-4-基 | 1 |
F-5221 | H | H | H | H | H | 3,5-F<sub>2</sub>-吡啶-4-基 | 1 |
F-5222 | H | H | H | H | H | 2,3-Cl<sub>2</sub>-吡啶-4-基 | 1 |
F-5223 | H | H | H | H | H | 2,5-Cl<sub>2</sub>-吡啶-4-基 | 1 |
[表315]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-5224 | H | H | H | H | H | 2,6-Cl<sub>2</sub>-吡啶-4-基 | 1 |
F-5225 | H | H | H | H | H | 3,5-Cl<sub>2</sub>-吡啶-4-基 | 1 |
F-5226 | H | H | H | H | H | 3-F-2-Cl-吡啶-4-基 | 1 |
F-5227 | H | H | H | H | H | 3-F-5-Cl-吡啶-4-基 | 1 |
F-5228 | H | H | H | H | H | 3-F-6-Cl-吡啶-4-基 | 1 |
F-5229 | H | H | H | H | H | 3-F-2-Me-吡啶-4-基 | 1 |
F-5230 | H | H | H | H | H | 3-F-5-Me-吡啶-4-基 | 1 |
F-5231 | H | H | H | H | H | 3-F-6-Me-吡啶-4-基 | 1 |
F-5232 | H | H | H | H | H | 3-F-2-OMe-吡啶-4-基 | 1 |
F-5233 | H | H | H | H | H | 3-F-5-OMe-吡啶-4-基 | 1 |
F-5234 | H | H | H | H | H | 3-F-6-OMe-吡啶-4-基 | 1 |
F-5235 | H | H | H | H | H | 3-Cl-2-F-吡啶-4-基 | 1 |
F-5236 | H | H | H | H | H | 3-Cl-6-F-吡啶-4-基 | 1 |
F-5237 | H | H | H | H | H | 3-Cl-2-Me-吡啶-4-基 | 1 |
F-5238 | H | H | H | H | H | 3-Cl-5-Me-吡啶-4-基 | 1 |
F-5239 | H | H | H | H | H | 3-Cl-6-Me-吡啶-4-基 | 1 |
F-5240 | H | H | H | H | H | 3-Me-2-F-吡啶-4-基 | 1 |
F-5241 | H | H | H | H | H | 3-Me-6-F-吡啶-4-基 | 1 |
F-5242 | H | H | H | H | H | 3-Me-2-Cl-吡啶-4-基 | 1 |
F-5243 | H | H | H | H | H | 3-Me-6-Cl-吡啶-4-基 | 1 |
F-5244 | H | H | H | H | H | 2,3-(Me)<sub>2</sub>-吡啶-4-基 | 1 |
F-5245 | H | H | H | H | H | 3,5-(Me)<sub>2</sub>-吡啶-4-基 | 1 |
F-5246 | H | H | H | H | H | 3,6-(Me)<sub>2</sub>-吡啶-4-基 | 1 |
F-5247 | H | H | H | H | H | 3-Me-2-OMe-吡啶-4-基 | 1 |
F-5248 | H | H | H | H | H | 3-Me-5-OMe-吡啶-4-基 | 1 |
F-5249 | H | H | H | H | H | 3-Me-6-OMe-吡啶-4-基 | 1 |
F-5250 | H | H | H | H | H | 3-CF<sub>3</sub>-2-F-吡啶-4-基 | 1 |
F-5251 | H | H | H | H | H | 3-CF<sub>3</sub>-5-F-吡啶-4-基 | 1 |
F-5252 | H | H | H | H | H | 3-CF<sub>3</sub>-6-F-吡啶-4-基 | 1 |
F-5253 | H | H | H | H | H | 3-CF<sub>3</sub>-2-Me-吡啶-4-基 | 1 |
F-5254 | H | H | H | H | H | 3-CF<sub>3</sub>-5-Me-吡啶-4-基 | 1 |
F-5255 | H | H | H | H | H | 3-CF<sub>3</sub>-6-Me-吡啶-4-基 | 1 |
F-5256 | H | H | H | H | H | 3-OMe-2-F-吡啶-4-基 | 1 |
F-5257 | H | H | H | H | H | 3-OMe-6-F-吡啶-4-基 | 1 |
F-5258 | H | H | H | H | H | 3-OMe-2-Cl-吡啶-4-基 | 1 |
F-5259 | H | H | H | H | H | 3-OMe-5-Cl-吡啶-4-基 | 1 |
F-5260 | H | H | H | H | H | 3-OMe-6-Cl-吡啶-4-基 | 1 |
F-5261 | H | H | H | H | H | 3-OMe-2-Me-吡啶-4-基 | 1 |
F-5262 | H | H | H | H | H | 3-OMe-6-Me-吡啶-4-基 | 1 |
F-5263 | H | H | H | H | H | 2,3-(OMe)<sub>2</sub>-吡啶-4-基 | 1 |
F-5264 | H | H | H | H | H | 3,5-(OMe)<sub>2</sub>-吡啶-4-基 | 1 |
F-5265 | H | H | H | H | H | 3,6-(OMe)<sub>2</sub>-吡啶-4-基 | 1 |
F-5266 | H | H | H | H | H | 嘧啶-2-基 | 1 |
F-5267 | H | H | H | H | H | 嘧啶-4-基 | 1 |
F-5268 | H | H | H | H | H | 5-F-嘧啶-4-基 | 1 |
F-5269 | H | H | H | H | H | 5-Me-嘧啶-4-基 | 1 |
F-5270 | H | H | H | H | H | 5-CF3-嘧啶-4-基 | 1 |
F-5271 | H | H | H | H | H | 5-OMe-嘧啶-4-基 | 1 |
F-5272 | H | H | H | H | H | 嘧啶-5-基 | 1 |
F-5273 | H | H | H | H | H | 4-F-嘧啶-5-基 | 1 |
F-5274 | H | H | H | H | H | 4-Cl-嘧啶-5-基 | 1 |
F-5275 | H | H | H | H | H | 4-Me-嘧啶-5-基 | 1 |
F-5276 | H | H | H | H | H | 4-CF<sub>3</sub>-嘧啶-5-基 | 1 |
F-5277 | H | H | H | H | H | 4-OMe-嘧啶-5-基 | 1 |
F-5278 | H | H | H | H | H | 哒嗪-3-基 | 1 |
F-5279 | H | H | H | H | H | 4-F-哒嗪-3-基 | 1 |
F-5280 | H | H | H | H | H | 4-Cl-哒嗪-3-基 | 1 |
[表316]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-5281 | H | H | H | H | H | 4-Me-哒嗪-3-基 | 1 |
F-5282 | H | H | H | H | H | 4-CF<sub>3</sub>-哒嗪-3-基 | 1 |
F-5283 | H | H | H | H | H | 4-OMe-哒嗪-3-基 | 1 |
F-5284 | H | H | H | H | H | 哒嗪-4-基 | 1 |
F-5285 | H | H | H | H | H | 3-F-哒嗪-4-基 | 1 |
F-5286 | H | H | H | H | H | 3-Cl-哒嗪-4-基 | 1 |
F-5287 | H | H | H | H | H | 3-Me-哒嗪-4-基 | 1 |
F-5288 | H | H | H | H | H | 3-CF<sub>3</sub>-哒嗪-4-基 | 1 |
F-5289 | H | H | H | H | H | 3-OMe-哒嗪-4-基 | 1 |
F-5290 | H | H | H | H | H | 5-F-哒嗪-4-基 | 1 |
F-5291 | H | H | H | H | H | 5-Cl-哒嗪-4-基 | 1 |
F-5292 | H | H | H | H | H | 5-Me-哒嗪-4-基 | 1 |
F-5293 | H | H | H | H | H | 5-CF<sub>3</sub>-哒嗪-4-基 | 1 |
F-5294 | H | H | H | H | H | 5-OMe-哒嗪-4-基 | 1 |
F-5295 | H | H | H | H | H | 噻吩-2-基 | 1 |
F-5296 | H | H | H | H | H | 3-F-噻吩-2-基 | 1 |
F-5297 | H | H | H | H | H | 3-Cl-噻吩-2-基 | 1 |
F-5298 | H | H | H | H | H | 3-Me-噻吩-2-基 | 1 |
F-5299 | H | H | H | H | H | 3-CF<sub>3</sub>-噻吩-2-基 | 1 |
F-5300 | H | H | H | H | H | 3-OMe-噻吩-2-基 | 1 |
F-5301 | H | H | H | H | H | 噻吩-3-基 | 1 |
F-5302 | H | H | H | H | H | 2-F-噻吩-3-基 | 1 |
F-5303 | H | H | H | H | H | 2-Cl-噻吩-3-基 | 1 |
F-5304 | H | H | H | H | H | 2-Me-噻吩-3-基 | 1 |
F-5305 | H | H | H | H | H | 2-CF<sub>3</sub>-噻吩-3-基 | 1 |
F-5306 | H | H | H | H | H | 2-OMe-噻吩-3-基 | 1 |
F-5307 | H | H | H | H | H | 4-F-噻吩-3-基 | 1 |
F-5308 | H | H | H | H | H | 4-Cl-噻吩-3-基 | 1 |
F-5309 | H | H | H | H | H | 4-Me-噻吩-3-基 | 1 |
F-5310 | H | H | H | H | H | 4-CF<sub>3</sub>-噻吩-3-基 | 1 |
F-5311 | H | H | H | H | H | 4-OMe-噻吩-3-基 | 1 |
F-5312 | H | H | H | H | H | 噻唑-2-基 | 1 |
F-5313 | H | H | H | H | H | 噻唑-4-基 | 1 |
F-5314 | H | H | H | H | H | 5-F-噻唑-4-基 | 1 |
F-5315 | H | H | H | H | H | 5-Me-噻唑-4-基 | 1 |
F-5316 | H | H | H | H | H | 5-CF<sub>3</sub>-噻唑-4-基 | 1 |
F-5317 | H | H | H | H | H | 5-OMe-噻唑-4-基 | 1 |
F-5318 | H | H | H | H | H | 噻唑-5-基 | 1 |
F-5319 | H | H | H | H | H | 4-F-噻唑-5-基 | 1 |
F-5320 | H | H | H | H | H | 4-Me-噻唑-5-基 | 1 |
F-5321 | H | H | H | H | H | 4-CF<sub>3</sub>-噻唑-5-基 | 1 |
F-5322 | H | H | H | H | H | 4-OMe-噻唑-5-基 | 1 |
F-5323 | H | H | H | H | H | 1H-吡咯-1-基 | 1 |
F-5324 | H | H | H | H | H | 2-F-1H-吡咯-1-基 | 1 |
F-5325 | H | H | H | H | H | 2-Me-1H-吡咯-1-基 | 1 |
F-5326 | H | H | H | H | H | 2-CF<sub>3</sub>-1H-吡咯-1-基 | 1 |
F-5327 | H | H | H | H | H | 2-OMe-1H-吡咯-1-基 | 1 |
F-5328 | H | H | H | H | H | 1H-吡咯-2-基 | 1 |
F-5329 | H | H | H | H | H | 1-Me-1H-吡咯-2-基 | 1 |
F-5330 | H | H | H | H | H | 3-F-1H-吡咯-2-基 | 1 |
F-5331 | H | H | H | H | H | 3-Me-1H-吡咯-2-基 | 1 |
F-5332 | H | H | H | H | H | 3-CF<sub>3</sub>-1H-吡咯-2-基 | 1 |
F-5333 | H | H | H | H | H | 3-OMe-1H-吡咯-2-基 | 1 |
F-5334 | H | H | H | H | H | 1-Me-3-F-1H-吡咯-2-基 | 1 |
F-5335 | H | H | H | H | H | 1,3-(Me)<sub>2</sub>-1H-吡咯-2-基 | 1 |
F-5336 | H | H | H | H | H | 1-Me-3-CF<sub>3</sub>-1H-吡咯-2-基 | 1 |
F-5337 | H | H | H | H | H | 1-Me-3-OMe-1H-吡咯-2-基 | 1 |
[表317]
化合物编号 | R<sup>1</sup> | R<sup>2</sup> | R<sup>3</sup> | R<sup>4</sup> | R<sup>5</sup> | Q' | p |
F-5338 | H | H | H | H | H | 1H-吡咯-3-基 | 1 |
F-5339 | H | H | H | H | H | 1-Me-1H-吡咯-3-基 | 1 |
F-5340 | H | H | H | H | H | 2-F-1H-吡咯-3-基 | 1 |
F-5341 | H | H | H | H | H | 2-Me-1H-吡咯-3-基 | 1 |
F-5342 | H | H | H | H | H | 2-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
F-5343 | H | H | H | H | H | 2-OMe-1H-吡咯-3-基 | 1 |
F-5344 | H | H | H | H | H | 1-Me-2-F-1H-吡咯-3-基 | 1 |
F-5345 | H | H | H | H | H | 1,2-(Me)<sub>2</sub>-1H-吡咯-3-基 | 1 |
F-5346 | H | H | H | H | H | 1-Me-2-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
F-5347 | H | H | H | H | H | 1-Me-2-OMe-1H-吡咯-3-基 | 1 |
F-5348 | H | H | H | H | H | 4-F-1H-吡咯-3-基 | 1 |
F-5349 | H | H | H | H | H | 4-Me-1H-吡咯-3-基 | 1 |
F-5350 | H | H | H | H | H | 4-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
F-5351 | H | H | H | H | H | 4-OMe-1H-吡咯-3-基 | 1 |
F-5352 | H | H | H | H | H | 1-Me-4-F-1H-吡咯-3-基 | 1 |
F-5353 | H | H | H | H | H | 1,4-(Me)2-1H-吡咯-3-基 | 1 |
F-5354 | H | H | H | H | H | 1-Me-4-CF<sub>3</sub>-1H-吡咯-3-基 | 1 |
F-5355 | H | H | H | H | H | 1-Me-4-OMe-1H-吡咯-3-基 | 1 |
F-5356 | H | H | H | H | H | 1H-吡唑-1-基 | 1 |
F-5357 | H | H | H | H | H | 5-F-1H-吡唑-1-基 | 1 |
F-5358 | H | H | H | H | H | 5-Cl-1H-吡唑-1-基 | 1 |
F-5359 | H | H | H | H | H | 5-Me-1H-吡唑-1-基 | 1 |
F-5360 | H | H | H | H | H | 5-CF<sub>3</sub>-1H-吡唑-1-基 | 1 |
F-5361 | H | H | H | H | H | 5-OMe-1H-吡唑-1-基 | 1 |
F-5362 | H | H | H | H | H | 1H-吡唑-3-基 | 1 |
F-5363 | H | H | H | H | H | 1-Me-1H-吡唑-3-基 | 1 |
F-5364 | H | H | H | H | H | 4-F-1H-吡唑-3-基 | 1 |
F-5365 | H | H | H | H | H | 4-Cl-1H-吡唑-3-基 | 1 |
F-5366 | H | H | H | H | H | 4-Me-1H-吡唑-3-基 | 1 |
F-5367 | H | H | H | H | H | 4-CF<sub>3</sub>-1H-吡唑-3-基 | 1 |
F-5368 | H | H | H | H | H | 4-OMe-1H-吡唑-3-基 | 1 |
F-5369 | H | H | H | H | H | 1-Me-4-F-1H-吡唑-3-基 | 1 |
F-5370 | H | H | H | H | H | 1-Me-4-Cl-1H-吡唑-3-基 | 1 |
F-5371 | H | H | H | H | H | 1,4-(Me)<sub>2</sub>-1H-吡唑-3-基 | 1 |
F-5372 | H | H | H | H | H | 1-Me-4-CF<sub>3</sub>-1H-吡唑-3-基 | 1 |
F-5373 | H | H | H | H | H | 1-Me-4-OMe-1H-吡唑-3-基 | 1 |
F-5374 | H | H | H | H | H | 1H-吡唑-4-基 | 1 |
F-5375 | H | H | H | H | H | 1-Me-1H-吡唑-4-基 | 1 |
F-5376 | H | H | H | H | H | 3-F-1H-吡唑-4-基 | 1 |
F-5377 | H | H | H | H | H | 3-Cl-1H-吡唑-4-基 | 1 |
F-5378 | H | H | H | H | H | 3-Me-1H-吡唑-4-基 | 1 |
F-5379 | H | H | H | H | H | 3-CF<sub>3</sub>-1H-吡唑-4-基 | 1 |
F-5380 | H | H | H | H | H | 3-OMe-1H-吡唑-4-基 | 1 |
F-5381 | H | H | H | H | H | 1-Me-3-F-1H-吡唑-4-基 | 1 |
F-5382 | H | H | H | H | H | 1-Me-3-Cl-1H-吡唑-4-基 | 1 |
F-5383 | H | H | H | H | H | 1,3-(Me)2-1H-吡唑-4-基 | 1 |
F-5384 | H | H | H | H | H | 1-Me-3-CF<sub>3</sub>-1H-吡唑-4-基 | 1 |
F-5385 | H | H | H | H | H | 1-Me-3-OMe-1H-吡唑-4-基 | 1 |
F-5386 | H | H | H | H | H | 5-F-1H-吡唑-4-基 | 1 |
F-5387 | H | H | H | H | H | 5-Cl-1H-吡唑-4-基 | 1 |
F-5388 | H | H | H | H | H | 5-Me-1H-吡唑-4-基 | 1 |
F-5389 | H | H | H | H | H | 5-CF<sub>3</sub>-1H-吡唑-4-基 | 1 |
F-5390 | H | H | H | H | H | 5-OMe-1H-吡唑-4-基 | 1 |
F-5391 | H | H | H | H | H | 1-Me-5-F-1H-吡唑-4-基 | 1 |
F-5392 | H | H | H | H | H | 1-Me-5-Cl-1H-吡唑-4-基 | 1 |
F-5393 | H | H | H | H | H | 1,5-(Me)<sub>2</sub>-1H-吡唑-4-基 | 1 |
F-5394 | H | H | H | H | H | 1-Me-5-CF<sub>3</sub>-1H-吡唑-4-基 | 1 |
[表318]
[表319]
另一方面,可以按照以下所示的制造方法制造由通式[I]或[II]表示的本发明的化合物,但并不限于如下所示的制造方法。以下,例如,“由通式[I]所示的化合物”、“由式[I]所示的化合物”以及“化合物[I]”是同义的。
<制造方法1>
在本发明的化合物之中,由通式[VI]所示的化合物例如可以按照以下方法制造。
[化学式3]
(式中,R17表示C1-C6烷基,R18表示C1-C6烷基、C1-C6卤代烷基、二(C1-C6烷基)氨基或是未取代的或经(R9)m取代的苯基,X1表示卤素原子,并且R1、R2、R3、R4、R5以及R9如上文所定义)。
也就是说,可以通过在适当的溶剂中并在适当的碱存在下使化合物[III]与化合物[IV]或化合物[V]进行反应,从而制造由通式[VI]所示的化合物。
本反应中使用的通式[III]所示的化合物可根据WO 2012/028332 A、WO 2014/114649 A、WO 2016/027790 A、WO 2016/166250 A或US 5,055,482中所记载的方法或其他方法来制造。
相对于1摩尔的化合物[III],用于本反应的化合物[IV]或化合物[V]的使用量可以在1摩尔至5摩尔、优选1.0摩尔至2.0摩尔的范围内适当地选择。
可用于本反应的溶剂的实例包括:卤代烃类,例如二氯甲烷、氯仿、1,2-二氯乙烷或四氯化碳;醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;苯、甲苯、二甲苯、氯苯等的芳香族烃类;非质子性极性溶剂类,例如,N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲亚砜或环丁砜;脂肪族烃类,例如戊烷、己烷、环己烷或庚烷;腈类,例如乙腈或丙腈;吡啶类,例如吡啶或甲基吡啶;叔胺类,例如三乙胺或三丁胺;水、或上述的混合溶剂等。相对于1摩尔的化合物[III],溶剂的使用量为0.1升至300升,并且优选为0.3升至50升。
可用于本反应的碱的实例包括无机碱,例如碱金属的氢氧化物(例如氢氧化钠或氢氧化钾);碱土金属的氢氧化物(例如氢氧化钙或氢氧化镁);碱金属碳酸盐(例如碳酸钠或碳酸钾);碱金属的碳酸氢盐(例如碳酸氢钠或碳酸氢钾);金属氢化物(例如氢化钠或氢化钾);醇的金属盐(例如甲醇钠,乙醇钠或叔丁醇钾);或三乙胺、N,N-二甲基苯胺、吡啶、4-N,N-二甲氨基吡啶、1,8-二氮杂环[5.4.0]-7-十一烯等的有机碱类等。此外,相对于1摩尔的化合物[III],碱的使用量可以在1.0摩尔至5.0摩尔、优选1.0摩尔至3.5摩尔的范围内适当地选择。诸如三乙胺或吡啶等的有机碱也可以用作上述溶剂。
本反应的反应温度可以选自通常从-70℃至反应体系中的回流温度的任意温度范围,并且优选在0℃至150℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为10分钟至24小时。
反应结束后,向反应混合物中加水,然后用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[VI]。分离的化合物[VI]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法2>
在本发明的化合物之中,由通式[VIII]所示的化合物例如可以按照以下方法制造。
[化学式4]
(式中,R1、R2、R3、R4、R5、R17以及X1如上文所定义)。
也就是说,可在适当的溶剂中,在存在或不存在适当的酸、存在或不存在适当的氧化剂的条件下,通过使化合物[VII]与卤化剂反应来制造通式[VIII]所示的化合物。
本反应中使用的由通式[VII]所示的化合物可根据WO 2008/019357 A或WO 2008/157740 A中所记载的方法或其他方法进行制造。
可用于本反应的卤化剂的实例包括:氟、氯、溴、碘、N-氯丁二酰亚胺、N-溴丁二酰亚胺、N-碘丁二酰亚胺、磺酰氯、一氯化碘、次氯酸叔丁酯、N-氟-N'-(氯甲基)-三乙二胺双(四氟硼酸盐)、1-氟-2,6-二氯吡啶四氟硼酸盐或1,3-二溴-5,5-二甲基乙内酰脲。相对于1摩尔的化合物[VII],卤化剂的使用量可以在1.0摩尔至10摩尔、优选1.0摩尔至3.0摩尔的范围内适当地选择。
可用于本反应的氧化剂的实例包括:硝酸铈(IV)铵、过氧化氢或碘苯二乙酸酯。相对于1摩尔的化合物[VII],氧化剂的使用量可以在0摩尔至10摩尔、优选0摩尔至3.0摩尔的范围内适当地选择。
可用于本反应的溶剂的实例包括:无机酸类,例如硫酸;醚类,例如二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;芳香族烃类,例如苯、甲苯、二甲苯或氯苯;卤代烃类,例如二氯甲烷、氯仿、1,2-二氯乙烷或四氯化碳;非质子性极性溶剂类,例如N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲亚砜或环丁砜;醇类,例如甲醇、乙醇、2-丙醇或甲基溶纤剂;腈类,例如乙腈或丙腈;羧酸类,例如乙酸或三氟乙酸;吡啶类,例如吡啶或甲基吡啶;酮类,例如丙酮或甲乙酮;水、或上述的混合溶剂等。相对于1摩尔的化合物[VII],溶剂的使用量为0.1至100升,并且优选0.3至10升。
可用于本反应的酸的实例包括:无机酸类,例如硫酸;或羧酸类,例如乙酸或三氟乙酸。相对于1摩尔的化合物[VII],酸的使用量可以在1.0摩尔至10摩尔、优选0摩尔至3.0摩尔的范围内适当地选择。酸可以用作溶剂。
本反应的反应温度可以选自从-60℃至反应体系中的回流温度的任意温度范围,并且优选在-20℃至100℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为10分钟至24小时。
反应结束后,将水加入反应混合物中,然后用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[VIII]。分离的化合物[VIII]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法3>
例如可以按照以下方法制造本发明化合物中的由通式[XII]所示的化合物。
[化学式5]
(式中,L表示卤素原子、C1-C6烷基磺酰基氧基、C1-C6卤代烷基磺酰基氧基、二(C1-C6烷基)氨磺酰基氧基或是未取代的或经(R9)m取代的苯基磺酰基氧基,Q"表示未取代的或经(R8)m取代的C6-C10芳基或是未取代的或经(R8)m取代的杂芳基,R19表示基团OR16或基团NR6R7,并且m、R1、R2、R3、R4、R5、R6、R7、R8、R9以及R16如上文所定义)。
此处所使用的有些[X]或[XI]为已知化合物,一部分可从市售品获得。此外的部分也可以根据文献记载的方法、例如Chemical Review,1995年,第95卷,第2457页;Journalof Organic Chemistry,1995年,第60卷,第7508页;Journal of Organic Chemistry,1997年,第62卷,第6458页等所记载的方法而容易地合成。
也就是说,可以在适当的溶剂中,在适当的催化剂以及适当的碱的存在下,通过使化合物[IX]与化合物[X]或化合物[XI]进行反应,而制造由通式[XII]所示的化合物。
相对于1摩尔的化合物[IX],用于本反应的化合物[X]或化合物[XI]的使用量可以在1.0摩尔至10摩尔、优选1.0摩尔至3.0摩尔的范围内适当地选择。
用于本反应中的溶剂的实例包括:醚类,例如二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;芳香族烃类,例如苯、甲苯、二甲苯或氯苯;非质子性极性溶剂类,例如N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲亚砜或环丁砜;醇类,例如甲醇、乙醇、2-丙醇或甲基溶纤剂;戊烷、己烷、环己烷、庚烷等的脂肪族烃类;水、或上述混合溶剂等。此外,相对于1摩尔的化合物[IX],溶剂的使用量为0.1升至300升,并且优选为0.3升至50升。
可用于本反应中的催化剂的实例包括:钯催化剂,例如钯-碳、氯化钯、乙酸钯、三(二亚苄基丙酮)二钯、双(二亚苄基丙酮)钯、双(三苯基膦)二氯化钯、四(三苯基膦)钯、[1,1'-双(二苯基膦)二茂铁]二氯化钯或[1,2-双(二苯基膦)乙烷]二氯化钯;或铜催化剂,例如金属铜、乙酸铜(I)、乙酸铜(II)、氧化铜(I)、氧化铜(II)、氯化铜(I)或碘化铜(I)。
除了上述物质,还可以使用由钯催化剂与配位体制备的钯催化剂。钯催化剂的实例包括:乙酸钯、三(二亚苄基丙酮)二钯和双(二亚苄基丙酮)钯。配位体的实例包括:三苯基膦、三(叔丁基)膦、三环己膦、SPhos、Xantphos和BINAP。
相对于1摩尔的化合物[IX],催化剂的使用量可以在0.001摩尔至1.0摩尔、优选0.01摩尔至0.5摩尔的范围内适当地选择。
可用于本反应中的碱的实例包括:有机碱类,例如吡啶、二异丙基乙胺或三乙胺;碱金属的氢氧化物,例如氢氧化钠或氢氧化钾;碱金属的碳酸盐类,例如碳酸钠、碳酸钾或碳酸铯;碱金属的碳酸氢盐类,例如碳酸氢钠或碳酸氢钾;醇的金属盐类,例如甲醇钠、乙醇钠或叔丁醇钾;磷酸三钾、氟化钾或氟化铯等。相对于1摩尔的化合物[IX],碱的使用量可以在0.1摩尔至10摩尔、优选1.0摩尔至5.0摩尔的范围内适当地选择。
本反应的反应温度可以选自通常从-30℃至反应体系中的回流温度的任意温度范围,并且优选在0℃至150℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为1分钟至72小时。
反应结束后,向反应混合物中加水,然后滤出沉淀的固体或用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[XII]。分离的化合物[XII]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法4>
例如可以按照以下方法制造本发明化合物中的由通式[XIV]所示的化合物。
[化学式6]
(式中,Q、R1、R2、R3、R4、R5以及R17如上文所定义)。
也就是说,可以通过在适当的溶剂中,在适当的碱或适当的酸的存在下使化合物[XIII]进行水解反应,从而制造由通式[XIV]所示的化合物。
可用于本反应中的碱的实例包括:无机碱类,例如碱金属的氢氧化物(例如,氢氧化钠、氢氧化钾、氢氧化锂或氢氧化钡);碱金属的碳酸盐类(例如,碳酸钠或碳酸钾);碱金属的碳酸氢盐类(例如,碳酸氢钠或碳酸氢钾)。相对于1摩尔的化合物[XIII],碱的使用量可以在0.1摩尔至50摩尔、优选0.5摩尔至20摩尔的范围内适当地选择。
可用于本反应中的酸的实例包括:无机酸类,例如,盐酸、氢溴酸或硫酸;或羧酸类,例如,乙酸或三氟乙酸。相对于1摩尔的化合物[XIII],酸的使用量可以在1摩尔至1000摩尔、优选1摩尔至100摩尔的范围内适当地选择。
可用于本反应中的溶剂的实例包括:醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;芳香族烃类,例如苯、甲苯、二甲苯或氯苯;非质子性极性溶剂类,例如,N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲亚砜或环丁砜;醇类,例如,甲醇、乙醇、2-丙醇或甲基溶纤剂;腈类,例如乙腈或丙腈;酮类,例如丙酮或甲乙酮;水、或上述的混合溶剂等。此外,相对于1摩尔的化合物[XIII],溶剂的使用量为0.1升至500升,并且优选0.3升至30升。
本反应的反应温度可以选自通常从-30℃至反应体系中的回流温度的任意温度范围,并且优选在0℃至150℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为10分钟至72小时。
反应结束后,向反应混合物中加水中和,然后滤出沉淀的固体或用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[XIV]。分离的化合物[XIV]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法5>
例如也可以按照以下方法制造本发明化合物中的由通式[XVII]表示的化合物。
[化学式7]
(式中,Q、R1、R2、R3、R4、R5、R6、R7以及X1如上文所定义)。
也就是说,可以通过下述步骤制造由通式[XVII]表示的化合物:(步骤1)在适当的溶剂中、适当的催化剂存在下或不存在下,使用酸卤化剂使化合物[XIV]变成化合物[XV],(步骤2)然后在适当的溶剂中、适当的碱存在下或不存在下,与化合物[XVI]或其盐进行反应。
(步骤1)
可用于本反应中的酸卤化剂的实例包括:亚硫酰氯、草酰氯或磷酰氯。相对于1摩尔的化合物[XIV],酸卤化剂的使用量可以在0.1摩尔至30摩尔、优选0.5摩尔至10摩尔的范围内适当地选择。
可用于本反应中的催化剂的实例包括N,N-二甲基甲酰胺。相对于1摩尔的化合物[XIV],催化剂的使用量可以在0.01摩尔至1.0摩尔、优选0.01摩尔至0.1摩尔的范围内适当地选择。
可用于本反应中的溶剂的实例包括:醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;芳香族烃类,例如,苯、甲苯、二甲苯或氯苯;卤代烃类,例如,二氯甲烷、氯仿、1,2-二氯乙烷或四氯化碳;腈类,例如,乙腈或丙腈;酯类,例如,乙酸乙酯或丙酸乙酯;脂肪族烃类,例如,戊烷、己烷、环己烷或庚烷;或上述的混合溶剂等。相对于1摩尔的化合物[XIV],溶剂的使用量为0.1升至100升、优选为0.3升至10升。
本反应的反应温度可以选自通常从-30℃至反应体系中的回流温度的任意温度范围,并且优选在0℃至150℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为10分钟至24小时。
反应结束后,可以通过浓缩等操作来分离化合物[XV]。
(步骤2)
相对于1摩尔的化合物[XIV],本反应中使用的化合物[XVI]的使用量通常可以在1摩尔至500摩尔、优选1.0摩尔至300摩尔的范围内适当地选择。
可用于本反应中的溶剂的实例包括:醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;芳香族烃类,例如,苯、甲苯、二甲苯或氯苯;卤代烃类,例如,二氯甲烷、氯仿、1,2-二氯乙烷或四氯化碳;非质子性极性溶剂类,例如,N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲亚砜或环丁砜;醇类,例如,甲醇、乙醇、2-丙醇或甲基溶纤剂;腈类,例如,乙腈或丙腈;酯类,例如,乙酸乙酯或丙酸乙酯;脂肪族烃类,例如,戊烷、己烷、环己烷或庚烷;吡啶类,例如,吡啶或甲基吡啶;水、或上述的混合溶剂等。此外,相对于1摩尔的化合物[XV],溶剂的使用量为0.1升至500升、优选为0.2升至50升。
可用于本反应中的碱的实例包括:无机碱类,例如碱金属的氢氧化物(例如,氢氧化钠或氢氧化钾);碱土金属的氢氧化物(例如,氢氧化钙或氢氧化镁);碱金属的碳酸盐类(例如,碳酸钠或碳酸钾);碱金属的碳酸氢盐类(例如,碳酸氢钠或碳酸氢钾);金属氢化物类(例如,氢化钠或氢化钾);醇的金属盐类(例如,甲醇钠、乙醇钠或叔丁醇钾);或有机碱类,例如,三乙胺、N,N-二甲基苯胺、吡啶、4-N,N-二甲氨基吡啶、1,8-二氮杂环[5.4.0]-7-十一烯等。此外,相对于1摩尔的化合物[XV],碱的使用量可以在0摩尔至5摩尔、优选0摩尔至1.2摩尔的范围内适当地选择。
本反应的反应温度可以选自通常从-30℃至反应体系中的回流温度的任意温度范围,并且优选在0℃至150℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为10分钟至24小时。
反应结束后,向反应混合物中加水,然后滤出沉淀的固体或用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[XVII]。分离的化合物[XVII]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法6>
例如也可以按照以下方法制造本发明化合物中的由通式[XVII]表示的化合物。
[化学式8]
(式中,Q、R1、R2、R3、R4、R5、R6以及R7如上文所定义)。
也就是说,可以在适当的溶剂中,在适当的缩合剂及适当的碱存在下或不存在下,通过使化合物[XIV]与化合物[XVI]或其盐进行反应,从而制造由通式[XVII]表示的化合物。
相对于1摩尔的化合物[XIV],用于本反应的化合物[XVI]或其盐的使用量可以在1摩尔至10摩尔、优选1.0摩尔至3.0摩尔的范围内适当地选择。
可用于本反应中的缩合剂的实例包括:1-乙基-3-(3-二甲氨基丙基)碳二亚胺盐酸盐、1-乙基-3-(3-二甲氨基丙基)碳二亚胺盐酸盐与1-羟基苯并三唑的混合物、1-乙基-3-(3-二甲氨基丙基)碳二亚胺、1-乙基-3-(3二甲氨基丙基)碳二亚胺与1-羟基苯并三唑的混合物、N,N'-二环己基碳二亚胺、N,N'-二异丙基碳二亚胺、N,N'-羰基二咪唑、4-(4,6-二甲氧基-1,3,5-三嗪-2-基)-4-甲基吗啉鎓氯化物、1H-苯并三唑-1-基氧基三(二甲氨基)鏻六氟磷酸盐、{{[(1-氰基-2-乙氧基-2-氧代亚乙基)氨基]氧基}-4-吗啉基亚甲基}二甲基铵六氟磷酸盐、O-(7-氮杂苯并三唑-1-基)-N,N,N',N'-四甲基脲六氟磷酸盐等。此外,相对于1摩尔的化合物[XIV],缩合剂的使用量可以在1.0摩尔至10摩尔、优选1.0摩尔至6.0摩尔的范围内适当地选择。
当本反应中使用碱时,能够使用的碱的实例包括:有机碱类,例如,三乙胺、4-甲基吗啉、二异丙基乙胺、1,8-二氮杂双环[5.4.0]-7-十一烯、吡啶或2,6-二甲吡啶。此外,相对于1摩尔的化合物[XIV],碱的使用量可以在0摩尔至10摩尔、优选0.1摩尔至6.0摩尔的范围内适当地选择。
可用于本反应中的溶剂的实例包括:卤代烃类,例如,二氯甲烷、氯仿、1,2-二氯乙烷或四氯化碳;脂肪族烃类,例如,戊烷、己烷、环己烷或庚烷;酯类,例如,乙酸乙酯或丙酸乙酯;腈类,例如,乙腈或丙腈;非质子性极性溶剂类,例如,N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲亚砜或环丁砜;醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚等;或上述的混合溶剂等。相对于1摩尔的化合物[XIV],溶剂的使用量为0.1升至100升,优选为0.3升至50升。
本反应可以根据需要在催化剂的存在下进行,催化剂的实例包括4-(N,N-二甲基)氨基吡啶。相对于1摩尔的化合物[XIV],催化剂的使用量可以在0.001摩尔至10摩尔、优选为0.01摩尔至0.3摩尔的范围内适当地选择。
本反应的反应温度可以选自通常从-20℃至反应体系中的回流温度的任意温度范围,并且优选在0℃至80℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为1分钟至48小时。
反应结束后,向反应混合物中加水,然后滤出沉淀的固体或用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[XVII]。分离的化合物[XVII]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法7>
例如可以按照以下方法制造本发明化合物中的由通式[XVII]表示的化合物。
[化学式9]
(式中, Q、R1、R2、R3、R4、R5、R6、R7以及R17如上文所定义)。
也就是说,可以适当的溶剂中,在适当的碱存在下或不存在下,通过使通式[XIII]表示的化合物与通式[XVI]表示的化合物进行反应而制造由通式[XVII]表示的化合物。
相对于1摩尔的化合物[XIII],本反应中使用的化合物[XVI]的使用量通常可以在1.0摩尔至500摩尔、优选1.0摩尔至300摩尔的范围内适当地选择。
用于本反应中的溶剂的实例包括:醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;芳香族烃类,例如,苯、甲苯、二甲苯或氯苯;卤代烃类,例如,二氯甲烷、氯仿、1,2-二氯乙烷或四氯化碳;非质子性极性溶剂类,例如,N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲基亚砜或环丁砜;醇类,例如,甲醇、乙醇、2-丙醇或甲基溶纤剂;腈类,例如,乙腈或丙腈;酯类,例如,乙酸乙酯或丙酸乙酯;脂肪族烃类,例如,戊烷、己烷、环己烷或庚烷;吡啶类,例如,吡啶或甲基吡啶;水、或上述的混合溶剂等。此外,相对于1摩尔的化合物[XIII],溶剂的使用量为0.1升至500升,优选为0.2升至50升。
可用于本反应中的碱的实例包括:无机碱类,例如,碱金属的氢氧化物(例如,氢氧化钠或氢氧化钾);碱土金属的氢氧化物(例如,氢氧化钙或氢氧化镁);碱金属的碳酸盐类(例如,碳酸钠或碳酸钾);碱金属的碳酸氢盐类(例如,碳酸氢钠或碳酸氢钾);金属氢化物类(例如,氢化钠或氢化钾);醇的金属盐类(例如,甲醇钠、乙醇钠或叔丁醇钾);或有机碱类,例如,三乙胺、N,N-二甲基苯胺、吡啶、4-N,N-二甲氨基吡啶、1,8-二氮杂环[5.4.0]-7-十一烯等等。相对于1摩尔的化合物[XIII],碱的使用量可以在0至5.0摩尔、优选0至1.2摩尔的范围内适当地选择。
本反应的反应温度可以选自通常从-30℃至反应体系中的回流温度的任意温度范围,并且优选在0℃至150℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为10分钟至1星期。
反应结束后,向反应混合物中加水,然后用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[XVII]。分离的化合物[XVII]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法8>
例如可以按照以下方法制造本发明化合物中的由通式[XIX]表示的化合物。
[化学式10]
(式中,Q、R1、R2、R3、R4、R5以及R19如上文所定义)。
也就是说,可以在适当的溶剂中,在催化剂存在下或不存在下,通过使化合物[XVIII]与适当的氧化剂进行反应而制造通式[XIX]表示的化合物。
可用于本反应中的溶剂的实例包括:卤代烃类,例如,二氯甲烷、氯仿、1,2-二氯乙烷或四氯化碳;醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;非质子性极性溶剂类,例如,N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲基亚砜或环丁砜;醇类,例如,甲醇、乙醇、2-丙醇或甲基溶纤剂;酮类,例如丙酮或甲乙酮;腈类,例如,乙腈或丙腈;乙酸、水或它们的混合物。相对于1摩尔的化合物[XVIII],溶剂的使用量为0.1升至500升,优选为0.3升至200升。
可用于本反应中的氧化剂的实例包括:有机过氧化物,例如,间氯过氧苯甲酸、过甲酸或过醋酸;无机过氧化物,例如,过氧化氢、过锰酸钾、OXONE(注册商标,得自E.I.duPont de Nemours and Company,商品名,过氧硫酸氢钾含有物)或过碘酸钠。相对于1摩尔的化合物[XVIII],氧化剂的使用量为0.5摩尔至3.0摩尔。
可用于本反应中的催化剂的实例包括钨酸钠等。相对于1摩尔的化合物[XVIII],催化剂的使用量为0.01摩尔至0.5摩尔。
本反应的反应温度可以选自通常从-30℃至反应体系中的回流温度的任意温度范围,并且优选在-10℃至100℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为10分钟至48小时。
反应结束后,向反应混合物中加水,然后用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[XIX]。或者,可以通过浓缩反应混合物的溶剂而分离出化合物[XIX]。分离的化合物[XIX]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法9>
例如可以按照以下方法制造本发明化合物中的由通式[XX]表示的化合物。
[化学式11]
(式中,R20可相同或不同,其各自表示氢原子或C1-C6烷基,或是两个R20可一起形成-CH2CH2-或-C(CH3)2C(CH3)2-,L、R1、R2、R3、R4、R5以及R19如上文所定义)。
也就是说,可以在适当的溶剂中,在适当的催化剂及适当的碱存在下,通过使化合物[IX]与化合物-[B(OR20)2]2进行反应而制造通式[XX]表示的化合物。
相对于1摩尔的化合物[IX],用于本反应的化合物-[B(OR20)2]2的使用量可以在1摩尔至10摩尔、优选1.0摩尔至3.0摩尔的范围内适当地选择。
可用于本反应中的溶剂的实例包括:醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;芳香族烃类,例如,苯、甲苯、二甲苯或氯苯;非质子性极性溶剂类,例如N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲基亚砜或环丁砜;醇类,例如甲醇、乙醇、2-丙醇或甲基溶纤剂;脂肪族烃类,例如,戊烷、己烷、环己烷或庚烷;水、或上述的混合溶剂等。相对于1摩尔的化合物[IX],溶剂的使用量为0.1升至300升,优选为0.3升至50升。
可用于本反应中的催化剂的实例包括:钯催化剂,例如,钯-碳、氯化钯、乙酸钯、三(二亚苄基丙酮)二钯、双(二亚苄基丙酮)钯、双(三苯基膦)二氯化钯、四(三苯基膦)钯、[1,1'-双(二苯基膦)二茂铁]二氯化钯或[1,2-双(二苯基膦)乙烷]二氯化钯;或铜催化剂,例如,金属铜、乙酸铜(I)、乙酸铜(II)、氧化铜(I)、氧化铜(II)、氯化铜(I)或碘化铜(I)。
除了上述物质以外,也可使用由钯催化剂与配位体制备的钯催化剂。钯催化剂的实例包括:乙酸钯、三(二亚苄基丙酮)二钯和双(二亚苄基丙酮)钯。作为配位体的实例包括:三苯基膦、三(叔丁基)膦、三环己基膦、SPhos、Xantphos和BINAP。
相对于1摩尔的化合物[IX],催化剂的使用量可以在0.001摩尔至1.0摩尔、优选0.01摩尔至0.5摩尔的范围内适当地选择。
用于本反应中的碱的实例包括:有机碱类,例如,吡啶、二异丙基乙胺或三乙胺;碱金属的碳酸盐类,例如,碳酸钠、碳酸钾或碳酸铯;碱金属的碳酸氢盐类,例如,碳酸氢钠或碳酸氢钾;醇的金属盐类,例如,甲醇钠、乙醇钠或叔丁醇钾;磷酸三钾、氟化钾、氟化铯或乙酸钾。相对于1摩尔的化合物[IX],碱的使用量可以在0.1摩尔至10摩尔、优选1.0摩尔至5.0摩尔的范围内适当地选择。
本反应的反应温度可以选自通常从25℃至反应体系中的回流温度的任意温度范围,并且优选在30℃至150℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为1分钟至72小时。
反应结束后,向反应混合物中加水,然后滤出沉淀的固体或用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[XX]。分离的化合物[XX]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法10>
例如可以按照以下方法制造本发明化合物的中的由通式[XII]表示的化合物。
[化学式12]
(式中,Q”、L、R1、R2、R3、R4、R5、R19以及R20如上文所定义)。
也就是说,可以在适当的溶剂中,在适当的催化剂及适当的碱存在下,通过使化合物[XX]与化合物[XXI]进行反应而制造由通式[XII]表示的化合物。
相对于1摩尔的化合物[XX],用于本反应的化合物[XXI]的使用量可以在0.3摩尔至10摩尔、优选0.4摩尔至3.0摩尔的范围内适当地选择。
可用于本反应中的溶剂的实例包括:醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;芳香族烃类,例如,苯、甲苯、二甲苯或氯苯;非质子性极性溶剂类,例如N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲基亚砜或环丁砜;醇类,例如甲醇、乙醇、2-丙醇或甲基溶纤剂;脂肪族烃类,例如,戊烷、己烷、环己烷或庚烷;水、或上述的混合溶剂等。相对于1摩尔的化合物[XX],溶剂的使用量为0.1升至300升,优选为0.3升至50升。
可用于本反应中的催化剂的实例包括:钯催化剂,例如,钯-碳、氯化钯、乙酸钯、三(二亚苄基丙酮)二钯、双(二亚苄基丙酮)钯、双(三苯基膦)二氯化钯、四(三苯基膦)钯、[1,1'-双(二苯基膦)二茂铁]二氯化钯或[1,2-双(二苯基膦)乙烷]二氯化钯;或铜催化剂,例如,金属铜、乙酸铜(I)、乙酸铜(II)、氧化铜(I)、氧化铜(II)、氯化铜(I)或碘化铜(I)。
除了上述物质以外,也可使用由钯催化剂与配位体制备的钯催化剂。钯催化剂的实例包括:乙酸钯、三(二亚苄基丙酮)二钯和双(二亚苄基丙酮)钯。配位体的实例包括:三苯基膦、三(叔丁基)膦、三环己基膦、SPhos、Xantphos和BINAP。
相对于1摩尔的化合物[XX],催化剂的使用量可以在0.001摩尔至1.0摩尔、优选0.01摩尔至0.5摩尔的范围内适当地选择。
可用于本反应中的碱的实例包括:有机碱类,例如,吡啶、二异丙基乙胺或三乙胺;碱金属的氢氧化物,例如,氢氧化钠或氢氧化钾;碱金属的碳酸盐类,例如,碳酸钠、碳酸钾或碳酸铯;碱金属的碳酸氢盐类,例如,碳酸氢钠或碳酸氢钾;醇的金属盐类,例如,甲醇钠、乙醇钠或叔丁醇钾;磷酸三钾、氟化钾或氟化铯。相对于1摩尔的化合物[XX],碱的使用量可以在0.1摩尔至10摩尔、优选为1.0摩尔至5.0摩尔的范围内适当地选择。
本反应的反应温度可以选自通常从-30℃至反应体系中的回流温度的任意温度范围,并且优选在0℃至150℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为1分钟至72小时。
反应结束后,向反应混合物中加水,然后滤出沉淀的固体或用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[XII]。分离的化合物[XII]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法11>
例如,可以根据以下方法,通过使用通式[XVII]表示的化合物来制造本发明化合物中的由通式[XXII]表示的化合物。
[化学式13]
(式中,R1、R2、R3、R4、R5、R6、R7以及Q如上文所定义)。
也就是说,可以通过使化合物[XVII]与适当的硫化剂进行反应而制造通式[XXII]表示的化合物。
可用于本反应中的溶剂的实例包括:醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;芳香族烃类,例如,苯、甲苯、二甲苯或氯苯;非质子性极性溶剂类,例如,N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲基亚砜或环丁砜;卤代烃类,例如,二氯甲烷、氯仿、1,2-二氯乙烷或四氯化碳;脂肪族烃类,例如,戊烷、己烷、环己烷或庚烷;水、或上述的混合溶剂等。相对于1摩尔的化合物[XVII],溶剂的使用量为0.1升至300升,优选为0.3升至50升。
可用于本反应中的硫化剂的实例包括:五硫化二磷或劳森试剂。相对于1摩尔的化合物[XVII],硫化剂的使用量可以在0.5摩尔至30摩尔、优选0.5摩尔至5摩尔的范围内适当地选择。
本反应的反应温度可以选自通常从-70℃至反应体系中的回流温度的任意温度范围,并且优选在0℃至150℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为10分钟至24小时。
反应结束后,向反应混合物中加水,然后用有机溶剂进行萃取并进行浓缩等操作,从而可以分离出化合物[XXII]。或者,也可通过浓缩反应混合物的溶剂从而分离出化合物[XXII]。分离的化合物[XXII]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法12>
例如,可以根据以下方法,通过使用通式[XXIII]表示的化合物来制造本发明化合物中的由通式[XXVI]表示的化合物。
[化学式14]
(式中,R21表示C1-C6烷氧基、氨基、单(C1-C6烷基)氨基、二(C1-C6烷基)氨基、C1-C6烷硫基或C1-C6烷氧基C1-C6烷氧基,并且R1、R2、R3、R4、R5以及Q如上文所定义)。
也就是说,可以通过下述步骤制造通式[XXVI]表示的化合物:(步骤1)在适当的溶剂中或不存在溶剂的条件下,使用草酰氯将化合物[XXIII]变成化合物[XXIV],然后(步骤2)在适当的溶剂中或不存在溶剂的条件下,与化合物[XXV]或其盐进行反应。
(步骤1)
相对于1摩尔的化合物[XXIII],草酰氯的使用量可以在1.0摩尔至1000摩尔、优选摩尔1.0至300摩尔的范围内适当地选择。
可用于本反应中的溶剂的实例包括:醚类,例如,二乙醚、四氢呋喃、甲基叔丁醚或1,4-二噁烷;芳香族烃类,例如,苯、甲苯、二甲苯或氯苯;卤代烃类,例如,二氯甲烷、氯仿、1,2-二氯乙烷或四氯化碳;非质子性极性溶剂类,例如,N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲基亚砜或环丁砜;腈类,例如,乙腈或丙腈;酯类,例如,乙酸乙酯或丙酸乙酯、或上述的混合溶剂。相对于1摩尔的化合物[XXIII],溶剂的使用量为0.1升至500升,优选为0.2升至50升。
本反应的反应温度可以选自通常从0℃至反应体系中的回流温度的任意温度范围,并且优选在20℃至90℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为1分钟至6小时。
反应结束后,通过进行浓缩等操作,从而可将化合物[XXIV]分离。
(步骤2)
相对于1摩尔的化合物[XXIV],本反应中使用的化合物[XXV]的使用量可以从通常的1.0摩尔至500摩尔、优选1.0摩尔至300摩尔的范围内适当地选择。
可用于本反应中的溶剂的实例包括:醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;卤代烃类,例如,二氯甲烷、氯仿、1,2-二氯乙烷或四氯化碳;非质子性极性溶剂类,例如,N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲基亚砜或环丁砜;腈类,例如,乙腈或丙腈;酯类,例如,乙酸乙酯或丙酸乙酯、或上述的混合溶剂等。相对于1摩尔的化合物[XXIV],溶剂的使用量为0.1升至500升,优选为0.2升至50升。
本反应的反应温度可以选自通常从-30℃至反应体系中的回流温度的任意温度范围,并且优选在-10℃至100℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为5分钟至24小时。
反应结束后,向反应混合物中加水,然后滤出沉淀的固体或用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出这种化合物[XXVI]。分离的化合物[XXVI]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
<制造方法13>
例如可根据以下方法,通过使用由通式[XXVII]表示的化合物来制造本发明化合物中的由通式[XVII]表示的化合物。
[化学式15]
(式中,X2表示卤素原子、C1-C6烷基磺酰基氧基、三氟甲烷磺酰基氧基、九氟丁基磺酰基氧基、苯基磺酰基氧基、4-甲苯磺酰基氧基、C1-C6烷基磺酰基、苯基磺酰基或4-甲苯磺酰基,并且R1、R2、R3、R4、R5、R6、R7以及Q如上文所定义)。
也就是说,可在适当的溶剂中,在适当的碱存在下或不存在下,通过使化合物[XXVII]与化合物[XXVIII]或化合物[XXIX]进行反应而制造通式[XVII]表示的化合物。
相对于1摩尔的化合物[XXVII],用于本反应的化合物[XXVIII]或化合物[XXIX]的使用量可以在1.0摩尔至10摩尔、优选1.0摩尔至5.0摩尔的范围内适当地选择。
可用于本反应中的溶剂的实例包括:醚类,例如,二乙醚、四氢呋喃、1,4-二噁烷、1,2-二甲氧基乙烷或甲基叔丁醚;芳香族烃类,例如,苯、甲苯、二甲苯或氯苯;非质子性极性溶剂类,例如,N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、N-甲基-2-吡咯烷酮、二甲基亚砜或环丁砜;腈类,例如,乙腈或丙腈;脂肪族烃类,例如,戊烷、己烷、环己烷或庚烷;吡啶类,例如,吡啶或甲基吡啶;水、或上述的混合溶剂等。此外,相对于1摩尔的化合物[XXVII],溶剂的使用量为0.1升至300升,优选为0.3升至50升。
可用于本反应中的碱的实例包括:无机碱类,例如,碱金属的氢氧化物(例如,氢氧化钠或氢氧化钾);碱土金属的氢氧化物(例如,氢氧化钙或氢氧化镁);碱金属的碳酸盐类(例如,碳酸钠或碳酸钾);碱金属的碳酸氢盐类(例如,碳酸氢钠或碳酸氢钾);金属氢化物类(例如,氢化钠或氢化钾);醇的金属盐类(例如,甲醇钠、乙醇钠或叔丁醇钾);或有机碱类,例如,三乙胺、N,N-二甲基苯胺、吡啶、4-N,N-二甲胺基吡啶、1,8-二氮杂环[5.4.0]-7-十一烯等。相对于1摩尔的化合物[XXVII],碱的使用量可以在1.0摩尔至10摩尔、优选1.0摩尔至6.0摩尔的范围内适当地选择。诸如三乙胺或吡啶之类的有机碱类也可用作溶剂。
本反应可以根据需要在催化剂的存在下进行,催化剂的实例包括:吡啶、4-(N,N-二甲基)氨基吡啶或4-吡咯烷基吡啶。相对于1摩尔的化合物[XXVII],催化剂的使用量可以在0.001摩尔至1.0摩尔、优选0.01摩尔至0.1摩尔的范围内适当地选择。
本反应的反应温度可以选自通常从-70℃至反应体系中的回流温度的任意温度范围,并且优选在0℃至150℃的范围内。
本反应的反应时间因反应温度、反应基质、反应量等而异,但通常为10分钟至24小时。
反应结束后,向反应混合物中加水,然后用有机溶剂萃取,然后进行浓缩等操作,从而可以分离出化合物[XVII]。分离的化合物[XVII]可以根据需要通过柱色谱法、重结晶法等进一步纯化。
本发明的农药组合物包含由本发明的通式[I]或[II]所示的吡唑衍生物或其农业上可接受的盐作为活性成分。
本发明的农药组合物可根据需要含有农药制剂中通常使用的添加成分(载体)。
本发明的有害生物防治剂包含由本发明的通式[I]或[II]所示的吡唑衍生物或其农业上可接受的盐作为活性成分。代表性的本发明的有害生物防治剂为杀虫剂及杀螨剂。
本发明的有害生物防治剂可根据需要含有农药制剂中通常使用的添加成分(载体)。
该添加成分的实例包括:载体(例如,固体载体或液体载体)、表面活性剂、粘合剂或赋粘剂、增粘剂、着色剂、扩展剂、展着剂、防冻剂、抗结块剂、崩解剂和分解防止剂,除上述以外,还可以根据需要在添加成分中添加防腐剂、植物碎片等。这些添加剂成分可以单独使用或两种以上组合使用。
以下对上述添加成分进行说明。
固体载体的实例包括:矿物载体,如叶蜡石黏土、高岭土、硅石黏土、滑石、硅藻土、沸石、膨润土、日本酸性黏土、活性黏土、凹凸棒石黏土(attapulgus clay)、蛭石、珍珠岩、轻石、白碳(合成硅酸、合成硅酸盐等)或二氧化钛;植物性载体,例如,木质粉、玉米茎、核桃壳、果实核、谷壳、锯屑、麸、大豆粉、粉末纤维素、淀粉、糊精或糖类;无机盐类载体,例如,碳酸钙、硫酸铵、硫酸钠或氯化钾;高分子载体,例如,聚乙烯、聚丙烯、聚氯乙烯、聚乙酸乙烯酯、乙烯-乙酸乙烯酯共聚物或脲醛树脂。
液体载体的实例包括:一元醇类,例如,甲醇、乙醇、丙醇、2-丙醇、丁醇或环己醇;多元醇类,例如,乙二醇、二乙二醇、丙二醇、己二醇、聚乙二醇、聚丙二醇或甘油;多元醇衍生物类,例如丙二醇醚;酮类,例如,丙酮、甲乙酮、甲基异丁酮、二异丁酮、环己酮或异佛尔酮;醚类,例如,乙醚、1,4-二噁烷、溶纤剂、二丙醚或四氢呋喃;脂肪族烃类,例如,正烷烃、环烷烃、异链烷烃、煤油或矿物油;芳香族烃类,例如,甲苯、C9-C10烷基苯、二甲苯、溶剂石油脑、烷基萘或高沸点芳香族烃;卤代烃类,例如,1,2-二氯乙烷、氯仿或四氯化碳;酯类,例如,乙酸乙酯、邻苯二甲酸二异丙酯、邻苯二甲酸二丁酯、邻苯二甲酸二辛酯或己二酸二甲酯;内酯类,例如,γ-丁内酯;酰胺类,例如,N,N-二甲基甲酰胺、N,N-二乙基甲酰胺、N,N-二甲基乙酰胺或N-甲基-2-吡咯烷酮;腈类,例如乙腈;硫化合物类,例如二甲基亚砜;植物油类,例如,大豆油、菜籽油、棉籽油、椰子油或蓖麻油;以及水。
尽管对于表面活性剂没有特别的限制,但优选为在水中胶化或呈现膨润性的表面活性剂,该表面活性剂的实例包括:非离子性表面活性剂,例如,脱水山梨醇脂肪酸酯、聚氧乙烯脱水山梨醇脂肪酸酯、蔗糖脂肪酸酯、聚氧乙烯脂肪酸酯、聚氧乙烯树脂酸酯、聚氧乙烯脂肪酸二酯、聚氧乙烯烷基醚、聚氧乙烯烷基苯基醚、聚氧乙烯二烷基苯基醚、聚氧乙烯烷基苯基醚福尔马林缩合物、聚氧乙烯聚氧丙烯嵌段聚合物、烷基聚氧乙烯聚丙烯嵌段聚合物醚、聚氧乙烯烷基胺、聚氧乙烯脂肪酸酰胺、聚氧乙烯脂肪酸双苯基醚、聚亚烷基苄基苯基醚、聚氧亚烷基苯乙烯基苯基醚、乙炔二醇、聚氧亚烷基加成乙炔二醇、聚氧乙烯醚型硅酮、酯型硅酮、氟表面活性剂、聚氧乙烯蓖麻油或聚氧乙烯硬化蓖麻油;阴离子性表面活性剂,例如,烷基硫酸盐、聚氧乙烯烷基醚硫酸盐、聚氧乙烯烷基苯基醚硫酸盐、聚氧乙烯苯乙烯基苯基醚硫酸盐、烷基苯磺酸盐、木质素磺酸盐、烷基磺基琥珀酸盐、萘磺酸盐、烷基萘磺酸盐、萘磺酸的福尔马林缩合物的盐、烷基萘磺酸的福尔马林缩合物的盐、脂肪酸盐、聚羧酸盐、N-甲基-脂肪酸肌氨酸盐、树脂酸盐、聚氧乙烯烷基醚磷酸盐或聚氧乙烯烷基苯基醚磷酸盐;阳离子表面活性剂,例如烷基胺盐,如月桂基胺盐酸盐、硬脂胺盐酸盐、油胺盐酸盐、硬脂胺乙酸盐、硬脂氨基丙胺乙酸盐、烷基三甲基氯化铵或烷基二甲基苯扎氯铵(alkyldimethylbenzarconium chloride);以及两性表面活性剂,包括甜菜碱型两性表面活性剂如二烷基二氨基乙基甜菜碱或烷基二甲基苄基甜菜碱,以及氨基酸型两性表面活性剂如二烷基氨基乙基甘氨酸或烷基二甲基苄基甘氨酸。
粘合剂或赋粘剂的实例包括:羧甲基纤维素或其盐、糊精、水溶性淀粉、黄原胶、瓜尔胶、蔗糖、聚乙烯吡咯烷酮、阿拉伯胶、聚乙烯醇、聚乙酸乙烯酯、聚丙烯酸钠、平均分子量为6000至20000的聚乙二醇、平均分子量为10万至500万的聚环氧乙烷、以及天然磷脂质(例如脑磷脂、卵磷脂等)。
增粘剂的实例包括:水溶性高分子类,例如,黄原胶、瓜尔胶、羧甲基纤维素、聚乙烯吡咯烷酮、羧乙烯基聚合物、丙烯酸类聚合物、淀粉衍生物或多糖;无机微粉,例如,高纯度膨润土或白碳。
着色剂的实例包括:无机颜料,例如,氧化铁、氧化钛或普鲁士蓝;有机染料,例如,茜素染料、偶氮染料或金属酞菁染料。
扩展剂的实例包括:有机硅表面活性剂、纤维素粉末、糊精、加工淀粉、聚氨基羧酸螯合物、交联聚乙烯吡咯烷酮、苹果酸与苯乙烯类、甲基丙烯酸共聚物、多元醇的聚合物与二羧酸酐的半酯和聚苯乙烯磺酸的水溶性盐。
展着剂的实例包括:各种表面活性剂,例如,二烷基磺基琥珀酸钠、聚氧乙烯烷基醚、聚氧乙烯烷基苯基醚或聚氧乙烯脂肪酸酯;石蜡、萜烯、聚酰胺树脂、聚丙烯酸盐、聚氧乙烯、蜡、聚乙烯基烷基醚、烷基酚福尔马林缩合物以及合成树脂乳化液等。
防冻剂的实例包括:多元醇类,例如,乙二醇、二乙二醇、丙二醇或甘油。
抗结块剂的实例包括:多糖类,例如,淀粉、藻酸、甘露糖或半乳糖;聚乙烯吡咯烷酮、白碳、酯胶和石油树脂。
崩解剂的实例包括:三聚磷酸钠、六偏磷酸钠、硬脂酸金属盐、纤维素粉末、糊精、甲基丙烯酸酯的共聚物、聚乙烯吡咯烷酮、聚氨基羧酸螯合物、苯乙烯磺酸盐-异丁烯-马来酸酐共聚物和淀粉-聚丙烯腈接枝共聚物。
分散防止剂的实例包括:干燥剂,例如,沸石、生石灰或氧化镁;基于苯酚、胺、硫、磷酸等的抗氧化剂;基于水杨酸、二苯甲酮等的紫外线吸收剂。
在本发明的有害生物防治剂中,当包含添加成分时,在添加成分为诸如固体载体或液体载体之类的载体的情况下,其含量通常按质量计在5%至95%的范围内、优选在20%至90%的范围内选择;在添加成分为表面活性剂的情况下,其含量通常在0.1%至30%的范围内、优选在0.5%至10%的范围内选择;并且在添加成分为其他添加剂的情况下,其含量通常在0.1%至30%的范围内、优选在0.5%至10%的范围内选择。
本发明的有害生物防治剂可制成任意制剂而使用,这些制剂包括:粉剂、粉粒剂、粒剂、水合剂、水溶剂、颗粒水合剂、片剂、大粒剂、乳剂、油剂、液剂、悬浮剂、乳化剂、微乳化剂、悬浮乳化剂、微量散布剂、微胶囊剂、烟雾剂、气溶胶剂、饵剂和糊剂。
在实际使用这些制剂时,可直接使用或以诸如水之类的稀释剂稀释成既定浓度而使用。可使用常规使用的施用方法来进行含有本发明的化合物的各种制剂或其稀释物的施用,例如喷洒(例如,喷雾、造雾、雾化、撒粉、撒粒、水面施用或苗箱施用)、土壤施用(例如,混入、灌注等)、表面施用(例如,涂布、粉衣或被覆)、种子处理(例如,涂抹或种衣处理)、浸渍、毒饵、烟雾等。此外,也可将上述活性成分混合至饲料,而防治其排泄物中的有害生物、特别是有害昆虫的产生和成长。
本发明的有害生物的防治方法可以通过在上述施用方法中使用活性成分量的本发明的通式[I]或[II]所示的吡唑衍生物或其农业上可接受的盐而进行。
本发明的有害生物防治剂中活性成分的混合比(质量%)可根据需求适当地选择。例如,在粉剂、粉粒剂、微粒剂等的情况下,混合比可适当选自0.01%至20%、优选为0.05%至10%的范围;在粒剂的情况下,可适当选自0.1%至30%、优选为0.5%至20%的范围;在水合剂、颗粒水合剂的情况下,可适当选自1%至70%、优选为5%至50%的范围;在水溶剂、液剂等的情况下,可适当选自1%至95%、优选为10%至80%的范围;在乳剂等的情况下,可适当选自5%至90%、优选为10%至80%的范围;在油剂的情况下,可适当选自1%至50%、优选为5%至30%的范围;在悬浮剂的情况下,可适当选自5%至60%、优选为10%至50%的范围;在乳化剂、微乳化剂、悬浮乳化剂的情况下,可适当选自5%至70%、优选为10%至60%的范围;在片剂、饵剂、糊剂等的情况下,可适当选自1%至80%、优选为5%至50%的范围;在烟雾剂的情况下,可适当选自0.1%至50%、优选为1%至30%的范围;在气溶胶剂情况下,可适当选自0.05%至20%、优选为0.1%至10%的范围。
以适当的浓度稀释后喷洒上述制剂,或直接施用上述制剂。
在以稀释剂稀释后使用本发明的有害生物防治剂时,活性成分的浓度一般为0.1ppm至5000ppm。将制剂直接使用时,以活性成分化合物计,每单位面积的施用量为每1ha使用0.1g至5000g;但并不限定于此。
不言而喻,当本发明的化合物单独用作活性成分时,本发明的有害生物防治剂也是足够有效的。但是,必要时,本发明的有害生物防治剂可以与其他肥料和农药,例如杀虫剂、杀螨剂、杀线虫剂、增效剂、杀真菌剂、抗病毒剂、引诱剂、除草剂、植物生长控制剂等等混合使用。在这种情况下,可以表现出更优异的效果。
下面示出了可以混合或组合使用的已知的杀虫剂、杀螨剂、杀线虫剂和增效剂化合物的实例。
杀虫活性成分:
氟酯菊酯(acrinathrin)、印楝素(azadirachtin)、甲基吡啶磷(azamethiphos)、阿色挪那皮(acynonapyr)、益棉磷(azinphos-ethyl)、保棉磷(azinphos-methyl)、灭螨醌(acequinocyl)、啶虫脒(acetamiprid)、乙酰虫腈(acetoprole)、乙酰甲胺磷((acephate)、三唑锡(azocyclotin)、齐墩螨素(abamectin)、双丙环虫酯(afidopyropen)、阿弗索拉纳(afoxolaner)、磺胺螨酯(amidoflumet)、双甲脒(amitraz)、棉铃威(alanycarb)、涕灭威(aldicarb)、氧涕灭威(aldoxycarb)、丙烯菊酯(allethrin)[包括d-顺-反-式和d-顺-式]、氯唑磷(isazophos)、衣胺磷(isamidofos)、水胺硫磷(isocarbophos)、噁唑磷(isoxathion)、异环司拉(isocycloseram)、甲基异柳磷(isofenphos-methyl)、异丙威(isoprocarb)、ε-甲氧苄氟菊酯(epsilon-metofluthrin)、ε-甲氧苄氟菊酯单体(epsilon-momfluorothrin)、伊维菌素(ivermectin)、新烟磷(imicyafos)、吡虫啉(imidacloprid)、炔咪菊酯(imiprothrin)、茚虫威(indoxacarb)、高氰戊菊酯(esfenvalerate)、乙硫苯威(ethiofencarb)、乙硫磷(ethion)、乙虫腈(ethiprole)、二溴乙烷(ethylenedibromide)、乙螨唑(etoxazole)、醚菊酯(etofenprox)、灭线磷(ethoprophos)、乙氧嘧啶磷(etrimfos)、甲氨基阿维菌素(emamectin)、甲氨基阿维菌素苯甲酸盐(emamectinbenzoate)、硫丹(endosulfan)、右旋烯炔菊酯(empenthrin)、唑硫非(oxazosulfyl)、杀线威(oxamyl)、亚砜磷(oxydemeton-methyl)、异砜磷(oxydeprofos)、氧乐果(omethoate)、硫线磷(cadusafos)、七氟菊酯(kappa-tefluthrin)、联苯菊酯(kappa-bifenthrin)、水黄皮素(karanjin)、杀螟丹(cartap)、甲萘威(carbaryl)、丁硫克百威(carbosulfan)、克百威(carbofuran)、灵丹(γ-BHC)、灭杀威(xylylcarb)、喹硫磷(quinalphos)、烯虫炔酯(kinoprene)、灭螨猛(chinomethionat)、蝇毒磷(coumaphos)、冰晶石(cryolite)、噻虫胺(clothianidin)、四螨嗪(clofentezine)、环虫酰肼(chromafenozide)、氯虫酰胺(chlorantraniliprole)、氯氧磷(chlorethoxyfos)、氯丹(chlordane)、氯化苦(chloropicrin)、毒死蜱(chlorpyrifos)、甲基毒死蜱(chlorpyrifos-methyl)、溴虫腈(chlorfenapyr)、毒虫畏(chlorfenvinphos)、氟啶脲(chlorfluazuron)、氯甲硫磷(chlormephos)、右旋反式氯丙炔菊酯(chloroprallethrin)、溴氰虫酰胺(cyazypyr)、杀螟腈(cyanophos)、丁醚脲(diafenthiuron)、除线特(diamidafos)、氰虫酰胺(cyantraniliprole)、除螨灵(dienochlor)、腈吡螨酯(cyenopyrafen)、水杨硫磷(dioxabenzofos)、苯虫醚(diofenolan)、环溴虫酰胺(cyclaniliprole)、环氧虫啶(cycloxaprid)、百治磷(dicrotophos)、除线磷(dichlofenthion)、乙氰菊酯(cycloprothrin)、敌敌畏(dichlorvos)、敌克美施(dicloromezotiaz)、三氯杀螨醇(dicofol)、环虫腈(dicyclanil)、乙拌磷(disulfoton)、呋虫胺(dinotefuran)、消螨通(dinobuton)、氯氟氰虫酰胺(cyhalodiamide)、三氟氯氰菊酯(cyhalothrin)[包括γ-型和λ-型]、苯醚氰菊酯(cyphenothrin)[包括(1R)-反-式]、氟氯氰菊酯(cyfluthrin)[包括β-型]、除虫脲(diflubenzuron)、丁氟螨酯(cyflumetofen)、氟螨嗪(diflovidazin)、三环锡(cyhexatin)、氯氰菊酯(cypermethrin)[包括α-型、β-型、θ型和ζ-型]、dimpropyridaz、二甲基-2,2,2-三氯-1-羟乙基磷酸酯(DEP)、甲基毒虫畏(dimethylvinphos)、乐果(dimethoate)、四氟甲醚菊酯(dimefluthrin)、硅白灵(silafluofen)、灭蝇胺(cyromazine)、乙基多杀菌素(spinetoram)、多杀菌素(spinosad)、螺螨酯(spirodiclofen)、螺虫乙酯(spirotetramat)、施必乐迪翁(spiropidion)、螺甲螨酯(spiromesifen)、磺苯醚隆-钠(sulcofuron-sodium)、氟虫胺(sulfluramid)、氟啶虫胺腈(sulfoxaflor)、治螟磷(sulfotep)、二嗪磷(diazinon)、噻虫啉(thiacloprid)、噻虫嗪(thiamethoxam)、替恶杀芬(tioxazafen)、硫双威(thiodicarb)、杀虫环(thiocyclam)、杀虫双(thiosultap)、治线磷(thionazin)、久效威(thiofanox)、甲基乙拌磷(thiometon)、替克乐比萨佛(tyclopyrazoflor)、四氯虫酰胺(tetrachlorantraniliprole)、杀虫畏(tetrachlorvinphos)、三氯杀螨砜(tetradifon)、氟氰虫酰胺(tetraniliprole)、四氟醚菊酯(tetramethylfluthrin)、胺菊酯(tetramethrin)、丁基嘧啶磷(tebupirimfos)、虫酰肼(tebufenozide)、吡螨胺(tebufenpyrad)、七氟菊酯(tefluthrin)、氟苯脲(teflubenzuron)、异吸硫磷(demeton-S-methyl)、双硫磷(temephos)、溴氰菊酯(deltamethrin)、特丁硫磷(terbufos)、四溴菊酯(tralomethrin)、四氟苯菊酯(transfluthrin)、唑蚜威(triazamate)、三唑磷(triazophos)、敌百虫(trichlorfon)、杀铃脲(triflumuron)、三氟苯嘧啶(triflumezopyrim)、混杀威(trimethacarb)、唑虫酰胺(tolfenpyrad)、二溴磷(naled)、硫酸烟碱(nicotine)、烯啶虫胺(nitenpyram)、尼莫克汀(nemadectin)、氟酰脲(novaluron)、多氟脲(noviflumuron)、蜡蚧轮枝菌(Verticilliumlecanii)、烯虫乙酯(hydroprene)、球形芽孢杆菌(Bacillus sphaericus)、枯草芽孢杆菌(Bacillus subtillis)、苏云金杆菌(Bacillus thuringiensis)、苏云金杆菌(Bacillusthuringiensis)所产生的昆虫毒素、苏云金芽胞杆菌鲇泽亚种菌株(Bacillusthuringiensis subsp.Aizawai)、苏云金芽孢杆菌以色列亚种菌株(Bacillusthuringiensis subsp.Israelensis)、苏云金芽孢杆菌库斯塔克亚种菌株(Bacillusthuringiensis subsp.Kurstaki)、苏云金芽胞杆菌拟步行甲亚种菌株(Bacillusthuringiensis subsp.Tenebrionis)、蛴螬乳状菌(Bacillus popilliae)、穿刺芽孢杆菌(Pasteuriapenetrans spore)、蚜灭多(vamidothion)、巴拉松(parathion)、甲基巴拉松(parathion-methyl)、扫螨宝(halfenprox)、氯虫酰肼(halofenozide)、生物丙烯菊酯(bioallethrin)、生物丙烯菊酯S-环戊烯酯(bioallethrin S-cyclopentenyl)、生物苄呋菊酯(bioresmethrin)、双-(2-氯-1-甲基乙基)醚(DCIP)、双三氟虫脲(bistrifluron)、伏蚁腙(hydramethylnon)、联苯肼酯(bifenazate)、氟氯菊酯(bifenthrin)、派福布麦(pyflubumide)、增效醚(piperonylbutoxide)、吡蚜酮(pymetrozine)、吡唑硫磷(pyraclofos)、吡嗪氟虫腈(pyrafluprole)、哒嗪硫磷(pyridaphenthion)、哒螨灵(pyridaben)、啶虫丙醚(pyridalyl)、氟虫吡喹(pyrifluquinazon)、吡啶氟虫腈(pyriprole)、蚊蝇醚(pyriproxyfen)、抗蚜威(pirimicarb)、嘧螨醚(pyrimidifen)、嘧螨胺(pyriminostrobin)、甲基嘧啶磷(pirimiphos-methyl)、除虫菊酯(pyrethrine)、伐灭磷(famphur)、氟虫腈(fipronil)、喹螨醚(fenazaquin)、苯线磷(fenamiphos)、杀螟硫磷(fenitrothion)、苯醚威(fenoxycarb)、苯硫威(fenothiocarb)、苯醚菊酯(phenothrin)[包括(1R)反式]、仲丁威(fenobucarb)、倍硫磷(fenthion)、稻丰散(phenthoate)、氰戊菊酯(fenvalerate)、唑螨酯(fenpyroximate)、杀螨锡(fenbutatinoxide)、甲氰菊酯(fenpropathrin)、地虫磷(fonofos)、硫酰氟(sulfurylfluoride)、丁酮威(butocarboxim)、丁酮砜威(butoxycarboxim)、噻嗪酮(buprofezin)、呋线威(furathiocarb)、炔丙菊酯(prallethrin)、嘧螨酯(fluacrypyrim)、三氟咪啶酰胺(fluazaindolizine)、啶蜱脲(fluazuron)、氟砜灵(fluensulfone)、氟吡菌酰胺(fluopyram)、氟乙酸钠(sodiumfluoroacetate)、氟米塔麦(fluxametamide)、氟螨脲(flucycloxuron)、氟氰戊菊酯(flucythrinate)、氟氰戊菊酯(flusulfamide)、氟氯氰菊酯(fluthrin)、氟胺氰菊酯(fluvalinate)[包括τ-型]、氟吡呋喃酮(flupyradifurone)、吡氟硫磷(flupyrazofos)、福拉庇力敏(flupyrimin)、丁虫腈(flufiprole)、嘧虫胺(flufenerim)、氟菌螨酯(flufenoxystrobin)、氟虫脲(flufenoxuron)、福拉海色芬(fluhexafon)、氟虫双酰胺(flubendiamide)、氟氯苯菊酯(flumethrin)、氟雷拉纳(fluralaner)、氟虫芬(flurimfen)、丙硫磷(prothiofos)、氯丙氟醚菊酯(protrifenbute)、氟啶虫酰胺(flonicamid)、丙虫磷(propaphos)、炔螨特(propargite)、丙溴磷(profenofos)、溴虫氟苯双酰胺(broflanilide)、丙氟菊酯(profluthrin)、胺丙畏(propetamphos)、残杀威(propoxur)、氟奎因(flometoquin)、溴螨酯(bromopropylate)、噻螨酮(hexythiazox)、氟铃脲(hexaflumuron)、细脚拟青霉(Pacilimy cestenuipes)、玫烟色拟青霉(Paecilomy cesfumosoroceus)、四氟甲醚菊酯(heptafluthrin)、庚烯磷(heptenophos)、氯菊酯(permethrin)、苯氯噻(benclothiaz)、苯辟力莫山(benzpyrimoxan)、苯硫丹(bensultap)、苯螨特(benzoximate)、恶虫威(bendiocarb)、丙硫克百威(benfuracarb)、纤细白僵菌(Beauveria tenella)、球孢白僵菌(Beauveriabassiana)、布氏白僵菌(Beauveria brongniartii)、辛硫磷(phoxim)、伏杀硫磷(phosalone)、噻唑磷(fosthiazate)、丁环硫磷(fosthietan)、磷胺(phosphamidon)、亚胺硫磷(phosmet)、浏阳霉素(polynactins)、伐虫脒(formetanate)、甲拌磷(phorate)、机油(machine oil)、马拉硫磷(malathion)、弥拜菌素(milbemectin)、灭蚜磷(mecarbam)、倍硫磷亚砜(mesulfenfos)、灭多威(methomyl)、四聚乙醛(metaldehyde)、氰氟虫腙(metaflumizone)、甲胺磷(methamidophos)、威百亩(metham)、甲硫威(methiocarb)、杀扑磷(methidathion)、异硫氰酸甲酯(methyl isothiocyanate)、溴代甲烷(methylbromide)、甲氧氯(methoxychlor)、甲氧虫酰肼(methoxyfenozide)、甲醚菊酯(methothrin)、甲氧苄氟菊酯(metofluthrin)、控虫素(methoprene)、速灭威(metolcarb)、速灭磷(mevinphos)、氯氟醚菊酯(meperfluthrin)、瘤捕单顶孢菌(Monacrosporiumphymatophagum)、久效磷(monocrotophos)、甲氧苄氟菊酯(momfluorothrin)、利露A(litlure-A)、利露B(litlure-B)、磷化铝(aluminium phosphide)、磷化锌(zincphosphide)、磷化氢(phosphine)、虱螨脲(lufenuron)、红圆蚧引诱剂(rescalure)、苄呋菊酯(resmethrin)、雷皮菌素(lepimectin)、鱼藤酮(rotenone)、核多角体病毒包埋体、杀螨锡(fenbutatin oxide)、氰化钙(calcium cyanide)、有机锡化合物(organotins)、硫酸烟碱(nicotine-sulfate)、(Z)-11-十四烯基=乙酸酯、(Z)-11-十六碳烯醛、(Z)-11-十六烯基=乙酸酯、(Z)-9,12-十四碳二烯基=乙酸酯、(Z)-9-十四烯基-1-醇、(Z,E)-9,11-十四碳二烯基=乙酸酯、(Z,E)-9,12-十四碳二烯基=乙酸酯、1,1,1-三氯-2,2-双(4-氯苯基)乙烷(DDT)、1,3-二氯丙烯(1,3-二氯丙烯)、2,4-二氯-5-{2-[4-(三氟甲基)苯基]乙氧基}苯基-2,2,2-三氟乙基亚砜(化学名,CAS登录号:1472050-04-6)、2,4-二氯-5-{2-[4-(三氟甲基)苯基]乙氧基}苯基2,2,2-三氟乙基亚砜(化学名,CAS登录号:1472052-11-1)、2,4-二甲基-5-[6-(三氟甲基硫代)己氧基]苯基-2,2,2-三氟乙基亚砜(化学名,CAS登录号:1472050-34-2)、2-{2-氟-4-甲基-5-[(2,2,2-三氟乙基)亚磺酰基]苯氧基}-5-(三氟甲基)吡啶(化学名,CAS登录号:1448758-62-0)、3-氯-2-{2-氟-4-甲基-5-[(2,2,2-三氟乙基)亚磺酰基]苯氧基}-5-(三氟甲基)吡啶(化学名,CAS登录号:1448761-28-1)、4,6-二硝基-邻甲酚(DNOC)、4-氟-2-甲基-5-(5,5-二甲基己氧基]苯基-2,2,2-三氟乙基亚砜(化学名,CAS登录号:1472047-71-4)、Bt蛋白(Cry1Ab、Cry1Ac、Cry1Fa、Cry2Ab、mCry3A、Cry3Ab、Cry3Bb、Cry34/35Ab1)、CL900167(代码编号)、NA-85(代码编号)、NI-30(代码编号)、O,O-二乙基-O-[4-(二甲基氨磺酰基)苯基]-硫代磷酸酯(DSP)、O-乙基-O-4-(硝苯基)苯基硫代膦酸酯(EPN)、RU15525(代码编号)、XMC(XMC)、Z-13-二十烷-10酮、ZXI8901(代码编号)。
接下来,下面示出了可以混合或组合使用的已知杀菌剂或病害防治化合物的实例。
杀菌活性成分:
阿扎康唑(azaconazole)、阿拉酸式苯-S-甲基(acibenzolar-S-methyl)、嘧菌酯(azoxystrobin)、敌菌灵(anilazine)、吲唑磺菌胺(amisulbrom)、胺基吡芬(aminopyrifen)、唑嘧菌胺(ametoctradin)、4-十二烷基-2,6-二甲基吗啉(aldimorph)、异噻菌胺(isotianil)、吡唑萘菌胺(isopyrazam)、异丙噻菌胺(isofetamid)、异氟西波(isoflucypram)、稻瘟灵(isoprothiolane)、种菌唑(ipconazole)、艾氟芬喹啉(ipflufenoquin)、氯氟醚菌唑(ipfentrifluconazole)、异菌脲(iprodione)、异丙菌胺(iprovalicarb)、异稻瘟净(iprobenfos)、抑霉唑(imazalil)、双胍辛烷基苯磺酸盐(iminoctadine-albesilate)、双胍辛胺乙酸盐(iminoctadine-triacetate)、亚胺唑(imibenconazole)、应吡福安(inpyrfluxam)、应普马汀A(imprimatinA)、应普马汀B(imprimatinB)、敌瘟磷(edifenphos)、乙环唑(etaconazole)、噻唑菌胺(ethaboxam)、乙嘧酚(ethirimol)、乙氧喹(ethoxyquin)、土菌灵(etridiazole)、烯肟菌酯(enestroburin)、烯肟菌胺(enoxastrobin)、氟环唑(epoxiconazole)、有机油(organic oils)、恶霜灵(oxadixyl)、恶嗪唑(oxazinylazole)、氟噻唑吡乙酮(oxathiapiprolin)、氧化萎锈灵(oxycarboxin)、喹啉铜(oxine-copper)、土霉素(oxytetracycline)、富马酸咪唑(oxpoconazole-fumarate)、喹菌酮(oxolinic acid)、二辛酸铜(copper dioctanoate)、辛噻酮(octhilinone)、呋酰胺(ofurace)、肟醚菌胺(orysastrobin)、邻苯基酚(o-phenylphenol)、春雷霉素(kasugamycin)、敌菌丹(captafol)、环丙酰菌胺(carpropamid)、多菌灵(carbendazime)、萎锈灵(carboxin)、香芹酮(carvone)、苯氧喹啉(quinoxyfen)、喹诺伏门林(quinofumelin)、灭螨猛(chinomethionat)、克菌丹(captan)、奎诺抗唑(quinconazole)、五氯硝基苯(quintozene)、双胍辛胺(guazatine)、硫杂灵(cufraneb)、甲香菌酯(coumethoxystrobin)、丁香菌酯(coumoxystrobin)、亚胺菌(kresoxim-methyl)、克拉康(clozylacon)、乙菌利(chlozolinate)、百菌清(chlorothalonil)、地茂散(chloroneb)、氰霜唑(cyazofamid)、乙霉威(diethofencarb)、双氯氰菌胺(diclocymet)、苯氟磺胺(dichlofluanid)、二氯苯赛铎(dichlobentiazox)、哒菌酮(diclomezine)、氯硝胺(dicloran)、二氯酚(dichlorophen)、二腈蒽醌(dithianon)、烯唑醇(diniconazole)、R-烯唑醇(diniconazole-M)、代森锌(zineb)、消螨普(dinocap)、迪庇美德松(dipymetitrone)、二苯胺(diphenylamine)、苯醚甲环唑(difenoconazole)、环氟菌胺(cyflufenamid)、二氟林(diflumetorim)、环唑醇(cyproconazole)、嘧菌环胺(cyprodinil)、硅氟唑(simeconazole)、甲菌定(dimethirimol)、二甲基二硫化物(dimethyldisulfide)、烯酰吗啉(dimethomorph)、霜脲氰(cymoxanil)、醚菌胺(dimoxystrobin)、罗氏假单胞菌HAI-0804(PseudomonasrhodesiaeHAI-0804)、福美锌(ziram)、硫硅菌胺(silthiofam)、链霉素(streptomycin)、螺环菌胺(spiroxamine)、氟唑环菌胺(sedaxane)、苯酰菌胺(zoxamide)、苯并烯氟菌唑(solatenol)、棉隆(dazomet)、黄蓝状菌(Talaromycesflavus)、噻酰菌胺(tiadinil)、噻菌灵(thiabendazole)、福美双(thiram)、硫菌灵(thiophanate)、甲基硫菌灵(thiophanate-methyl)、噻氟菌胺(thifluzamide)、福美双(thiram)、四氯硝基苯(tecnazene)、叶枯酞(tecloftalam)、四氟醚唑(tetraconazole)、咪菌威(debacarb)、戊唑醇(tebuconazole)、异丁乙氧喹啉(tebufloquin)、特比奈芬(terbinafine)、多果定(dodine)、吗菌灵(dodemorph)、三唑醇(triadimenol)、三唑酮(triadimefon)、咪唑嗪(triazoxide)、水杨菌胺(trichlamide)、氯啶菌酯(triclopyricarb)、深绿木霉菌(Trichoderma atroviride)、三环唑(tricyclazole)、灭菌唑(triticonazole)、十三吗啉(tridemorph)、氟菌唑(triflumizole)、肟菌酯(trifloxystrobin)、嗪胺灵(triforine)、甲苯氟磺胺(tolylfluanid)、甲基立枯磷(tolclofos-methyl)、甲磺菌胺(tolnifanide)、三氟甲氧威(tolprocarb)、代森钠(nabam)、那他霉素(natamycin)、萘替芬(naftifine)、三氯甲基吡啶(nitrapyrin)、酞菌酯(nitrothal-isopropyl)、氟苯嘧啶醇(nuarimol)、壬基酚磺酸铜(copper nonyl phenol sulphonate)、枯草芽孢杆菌(Bacillussubtilis)(菌株:QST713)、有效霉素(validamycin)、缬菌胺(valifenalate)、皮卡布西(picarbutrazox)、联苯吡菌胺(bixafen)、啶氧菌酯(picoxystrobin)、氟唑菌酰羟胺(pydiflumetofen)、联苯三唑醇(bitertanol)、乐杀螨(binapacryl)、桧木醇(hinokitiol)、联苯(biphenyl)、粉病灵(piperalin)、恶霉灵(hymexazol)、唑菌酯(pyraoxystrobin)、百克敏(pyraclostrobin)、吡蚜酮(pyraziflumid)、吡嘧磷(pyrazophos)、派普依(pyrapropoyne)、唑胺菌酯(pyrametostrobin)、必伏农(pyriofenone)、氯啶菌酯(pyrisoxazole)、必哒克缇(pyridachlometyl)、啶斑肟(pyrifenox)、稗草丹(pyributicarb)、吡菌苯威(pyribencarb)、嘧霉胺(pyrimethanil)、咯喹酮(pyroquilon)、乙烯菌核利(vinclozolin)、福美铁(ferbam)、唑菌酮(famoxadone)、叶枯净(phenazine oxide)、咪唑菌酮(fenamidone)、烯肟菌胺(fenaminstrobin)、氯苯嘧啶醇(fenarimol)、氰菌胺(fenoxanil)、嘧菌腙(ferimzone)、拌种咯(fenpiclonil)、芬吡克咪徳(fenpicoxamid)、胺苯吡菌酮(fenpyrazamine)、腈苯唑(fenbuconazole)、甲呋酰胺(fenfuram)、苯锈啶(fenpropidin)、丁苯吗啉(fenpropimorph)、环酰菌胺(fenhexamid)、灭菌丹(folpet)、苯酞(phthalide)、乙嘧酚磺酸酯(bupirimate)、麦穗宁(fuberidazole)、杀稻瘟素S(blasticidin-S)、呋吡酰胺(furametpyr)、呋霜灵(furalaxyl)、呋喃甲酸(furancarboxylic acid)、氟啶胺(fluazinam)、氟茚唑菌胺(fluindapyr)、氟嘧菌酯(fluoxastrobin)、氟派保林(fluoxapiprolin)、氟吡菌胺(fluopicolide)、氟醚菌酰胺(fluopimomide)、氟吡菌酰胺(fluopyram)、唑呋草(fluoroimide)、氟唑菌酰胺(fluxapyroxad)、氟喹唑(fluquinconazole)、呋醚唑(furconazole)、顺式呋醚唑(furconazole-cis)、氟咯菌腈(fludioxonil)、氟硅唑(flusilazole)、磺菌胺(flusulfamide)、氟噻菌净(flutianil)、氟酰胺(flutolanil)、粉唑醇(flutriafol)、氟菌螨酯(flufenoxystrobin)、氟联苯菌(flumetover)、氟吗啉(flumorph)、丙氧喹啉(proquinazid)、丙氯灵(prochloraz)、杀菌利(procymidone)、胺丙威(prothiocarb)、丙硫菌唑(prothioconazole)、溴硝醇(bronopol)、盐酸百维灵(propamocarb-hydrochloride)、丙环唑(propiconazole)、甲基代森锌(propineb)、噻菌灵(probenazole)、糠菌唑(bromuconazole)、孚螨喹(flometoquin)、氟洛萨米(florylpicoxamid)、己唑醇(hexaconazole)、本达乐(benalaxyl)、精苯霜灵(benalaxyl-M)、麦锈灵(benodanil)、苯菌灵(benomyl)、稻瘟酯(pefurazoate)、戊菌唑(penconazole)、戊菌隆(pencycuron)、苯并烯氟菌唑(benzovindiflupyr)、苯噻硫氰(benthiazole)、苯噻菌胺(benthiavalicarb-isopropyl)、吡噻菌胺(penthiopyrad)、氟唑菌苯胺(penflufen)、啶酰菌胺(boscalid)、三乙膦酸(fosetyl)(铝盐、钙盐、钠盐)、多氧菌素(polyoxin)、聚氨基甲酸盐(polycarbamate)、波尔多液(Bordeaux mixture)、代森锰铜(mancopper)、代森锰锌(mancozeb)、双炔酰菌胺(mandipropamid)、曼德斯托宾(mandestrobin)、代森锰(maneb)、腈菌唑(myclobutanil)、矿物油(mineral oils)、米多霉素(mildiomycin)、磺菌威(methasulfocarb)、威百亩(metam)、甲霜灵(metalaxyl)、精甲霜灵(metalaxyl-M)、代森联(metiram)、美特洛(metyltetraprole)、环戊唑菌(metconazole)、叉氨苯酰胺(metominostrobin)、苯菌酮(metrafenone)、嘧菌胺(mepanipyrim)、氯氟醚菌唑(mefentrifluconazole)、消螨多(meptyldinocap)、灭锈胺(mepronil)、碘卡布(iodocarb)、昆布多糖(laminarin)、葡萄根瘤菌(Rhizobium vitis)、亚磷酸和亚磷酸盐、王铜、银、氧化亚铜、氢氧化铜、碳酸氢钾、碳酸氢钠、硫、硫酸氧喹啉、硫酸铜、(3,4-二氯异噻唑-5-基)甲基-4-(叔丁基)苯甲酸酯(化学名,CAS登记号:1231214-23-5)、BAF-045(代码编号)、BAG-010(代码编号)、UK-2A(代码编号)、十二烷基苯磺酸双乙二胺铜盐[II]盐(DBEDC)、MIF-1002(代码编号)、NF-180(代码编号)、醋酸三苯锡(TPTA)、氯化三苯锡(TPTC)、氢氧化三苯锡(TPTH)、非病原性欧文氏菌(Erwinia carotovora)。
接下来,下面示出了可以混合或组合使用的已知除草剂或植物生长调节剂化合物的实例。
除草活性成分:
碘苯腈(ioxynil)、苯草醚(aclonifen)、丙烯醛(acrolein)、唑啶草酮(azafenidin)、三氟羧草醚(acifluorfen)(包括其钠盐等)、四唑嘧磺隆(azimsulfuron)、磺草灵(asulam)、乙草胺(acetochlor)、莠去津(atrazine)、莎稗磷(anilofos)、氨唑草酮(amicarbazone)、酰嘧磺隆(amidosulfuron)、杀草强(amitrole)、氯丙嘧啶酸(aminocyclopyrachlor)、氯氨吡啶酸(aminopyralid)、甲基胺草磷(amiprofos-methyl)、莠灭净(ametryn)、甲草胺(alachlor)、禾草灭(alloxydim)、嘧啶醇(ancymidol)、异隆(isouron)、异氯草酮(isoxachlortole)、异唑草酮(isoxaflutole)、异草胺(isoxaben)、乙氧基化异癸醇(Isodecylalkohol ethoxylate)、异丙隆(isoproturon)、三唑酰草胺(ipfencarbazone)、灭草喹(imazaquin)、甲咪唑烟酸(imazapic)(包括其胺盐等)、灭草烟(imazapyr)(包括异丙胺盐等)、咪草酸甲酯(imazamethabenz-methyl)、甲氧咪草烟(imazamox)、咪草烟(imazethapyr)、依速隆(imazosulfuron)、三嗪茚草胺(indaziflam)、茚草酮(indanofan)、甘草津(eglinazine-ethyl)、戊草丹(esprocarb)、胺苯磺隆(ethametsulfuron-methyl)、乙丁烯氟灵(ethalfluralin)、磺噻隆(ethidimuron)、乙氧嘧磺隆(ethoxysulfuron)、氯氟草醚乙酯(ethoxyfen-ethyl)、乙氧呋草黄(ethofumesate)、乙氧苯草胺(etobenzanid)、内氧草索钠盐(endothal-disodium)、草酮(oxadiazon)、丙炔草酮(oxadiargyl)、嗪草酮(oxaziclomefone)、环氧嘧磺隆(oxasulfuron)、乙氧氟草醚(oxyfluorfen)、氨磺乐灵(oryzalin)、嘧苯胺磺隆(orthosulfamuron)、坪草丹(orbencarb)、油酸(oleic acid)、唑草胺(cafenstrole)、唑酮草酯(carfentrazone-ethyl)、卡灵草(karbutilate)、卡草胺(carbetamide)、喹禾灵(quizalofop)、乙基喹禾灵(quizalofop-ethyl)、精喹禾灵(quizalofop-P-ethyl)、喹禾糠酯(quizalofop-P-tefuryl)、灭藻醌(quinoclamine)、二氯喹啉酸(quinclorac)、氯甲喹啉酸(quinmerac)、芐草隆(cumyluron)、氯酰草膦(clacyfos)、草甘膦(glyphosate)(包括钠盐、钾盐、胺盐、丙胺盐、异丙胺盐、二甲胺盐或三甲基硫盐)、草铵膦(glufosinate)(包括胺盐或钠盐)、草铵膦-P(glufosinate-P)、草铵膦-P-钠(glufosinate-P-sodium)、烯草酮(clethodim)、炔草酯(clodinafop-propargyl)、毕克草(clopyralid)、异噁草松(clomazone)、甲氧除草醚(chlomethoxyfen)、氯甲酰草胺(clomeprop)、氯酯磺草胺(cloransulam-methyl)、草灭平(chloramben)、氯草敏(chloridazon)、氯嘧磺隆(chlorimuron-ethyl)、氯磺隆(chlorsulfuron)、氯酞酸二甲酯(chlorthal-dimethyl)、赛草青(chlorthiamid)、氯酞亚胺(chlorphthalim)、甲基整形素(chlorflurenol-methyl)、氯苯胺灵(chlorpropham)、氯溴隆(chlorbromuron)、枯草隆(chloroxuron)、绿麦隆(chlorotoluron)、酮螺氧(ketospiradox)(包括钠盐、钙盐或氨盐)、苯嘧磺草胺(saflufenacil)、假蒟亭碱(sarmentine)、氰草津(cyanazine)、氨基氰(cyanamide)、敌草隆(diuron)、乙酰甲草胺(diethatyl-ethyl)、麦草畏(dicamba)(包括胺盐、二乙胺盐、异丙胺盐、二甘醇胺盐、钠盐或锂盐)、草灭特(cycloate)、噻草酮(cycloxydim)、双氯磺草胺(diclosulam)、环磺隆(cyclosulfamuron)、环吡宁(cyclopyranil)、环砒玛瑞(cyclopyrimorate)、敌草腈(dichlobenil)、精禾草灵(diclofop-P-methyl)、禾草灵(diclofop-methyl)、2,4-滴丙酸(dichlorprop)、精2,4-滴丙酸(dichlorprop-P)、敌草快(diquat)、氟硫草定(dithiopyr)、环草隆(siduron)、敌乐胺(dinitramine)、吲哚酮草酯(cinidon-ethyl)、醚磺隆(cinosulfuron)、地乐酚(dinoseb)、特乐酚(dinoterb)、氰氟草酯(cyhalofop-butyl)、大芬灭(diphenamid)、野燕枯(difenzoquat)、吡氟酰草胺(diflufenican)、氟吡草腙(diflufenzopyr)、草灭净(simazine)、二甲草胺(dimethachlor)、异戊乙净(dimethametryn)、二甲吩草胺(dimethenamid)、精二甲吩草胺(dimethenamid-P)、西草净(simetryn)、哌草丹(dimepiperate)、唑隆(dimefuron)、环庚草醚(cinmethylin)、灭草灵(swep)、磺草酮(sulcotrione)、甲磺草胺(sulfentrazone)、草硫膦(sulfosate)、磺酰磺隆(sulfosulfuron)、甲嘧磺隆(sulfometuron-methyl)、烯禾啶(sethoxydim)、特草定(terbacil)、杀草隆(daimuron)、萨克多敏A(thaxtomin A)、茅草枯(dalapon)、噻唑烟酸(thiazopyr)、氟丙嘧草酯(tiafenacil)、噻酮磺隆(thiencarbazone)(包括钠盐、甲酯等)、仲草丹(tiocarbazil)、禾草丹(thiobencarb)、噻二唑草胺(thidiazimin)、噻苯隆(thidiazuron)、甲基噻吩磺隆(thifensulfuron-methyl)、甜菜安(desmedipham)、敌草净(desmetryne)、特福披洛米(tetflupyrolimet)、甲氧噻草胺(thenylchlor)、牧草胺(tebutam)、得匍隆(tebuthiuron)、得杀草(tepraloxydim)、呋喃磺草酮(tefuryltrione)、特丁津(terbuthylazine)、特丁净(terbutryn)、甲氧去草净(terbumeton)、环磺酮(tembotrione)、苯吡唑草酮(topramezone)、肟草酮(tralkoxydim)、三嗪氟草胺(triaziflam)、醚苯磺隆(triasulfuron)、氟酮磺草胺(triafamone)、野麦畏(tri-allate)、草达津(trietazine)、绿草定(triclopyr)、三氯吡氧乙酸丁氧基乙酯(triclopyr-butotyl)、三氟甲磺隆(tritosulfuron)、三氟草嗪(trifludimoxazin)、氟胺磺隆(triflusulfuron-methyl)、三福林(trifluralin)、三氟啶磺隆钠盐(trifloxysulfuron-sodium)、苯磺隆(tribenuron-methyl)、tolpyralate、抑草生(naptalam)(包括其钠盐等)、萘丙胺(naproanilide)、草萘胺(napropamide)、草萘胺M(napropamide-M)、烟嘧磺隆(nicosulfuron)、草不隆(neburon)、氟草敏(norflurazon)、灭草猛(vernolate)、百草枯(paraquat dichloride)、苯甲基氟氯吡啶酯(halauxifen-benzyl)、甲基氟氯吡啶酯(halauxifen-methyl)、氟吡甲禾灵(haloxyfop)、高效氟吡甲禾灵(haloxyfop-P)、氟吡乙禾灵(haloxyfop-etotyl)、卤索芬(halosafen)、氯吡嘧磺隆(halosulfuron-methyl)、毕克斯隆索(bixlozone)、毒莠定(picloram)、氟吡酰草胺(picolinafen)、氟吡草酮(bicyclopyrone)、双草醚(bispyribac-sodium)、唑啉草酯(pinoxaden)、治草醚(bifenox)、哌草磷(piperophos)、双唑草腈(pyraclonil)、磺酰草吡唑(pyrasulfotole)、苄草唑(pyrazoxyfen)、吡嘧磺隆乙酯(pyrazosulfuron-ethyl)、苄草唑(pyrazolynate)、双丙氨酰膦(bilanafos)、吡草醚((pyraflufen-ethyl)、吡啶达醇(pyridafol)、嘧草硫醚(pyrithiobac-sodium)、哒草特(pyridate)、环酯草醚(pyriftalid)、稗草丹(pyributicarb)、嘧啶肟草醚(pyribenzoxim)、嘧啶硫蕃(pyrimisulfan)、嘧草醚(pyriminobac-methyl)、派罗克杀草砜(pyroxasulfone)、甲氧磺草胺(pyroxsulam)、棉胺宁(phenisopham)、非草隆(fenuron)、苯磺唑草(fenoxasulfone)、噁唑禾草灵(fenoxaprop)(包括甲酯、乙酯、异丙酯)、精噁唑禾草灵(fenoxaprop-P)(包括甲酯、乙酯、异丙酯)、芬昆诺三酮(fenquinotrione)、噻唑禾草灵(fenthiaprop-ethyl)、四唑酰草胺(fentrazamide)、苯敌草(phenmedipham)、双氟磺草胺(foramsulfuron)、丁草胺(butachlor)、氟丙嘧草酯(butafenacil)、抑草磷(butamifos)、丁草特(butylate)、丁烯草胺(butenachlor)、比达宁(butralin)、丁苯草酮(butroxydim)、啶嘧磺隆(flazasulfuron)、麦草氟(flamprop)(包括甲酯、乙酯、异丙酯)、麦草氟M(flamprop-M)(包括甲酯、乙酯、异丙酯)、甲基氟嘧磺隆(primisulfuron-methyl)、吡氟禾草灵(fluazifop-butyl)、精吡氟禾草灵(fluazifop-P-butyl)、异丙吡草酯(fluazolate)、氟草隆(fluometuron)、乙羧氟草乙醚(fluoroglycofen-ethyl)、氟酮磺隆钠(flucarbazone-sodium)、氟消草(fluchloralin)、氟吡磺隆(flucetosulfuron)、氟噻甲草酯(fluthiacet-methyl)、氟啶嘧磺隆(flupyrsulfuron-methyl)(包括钠盐、钙盐或氨盐)、氟噻草胺(flufenacet)、氟哒嗪草酯(flufenpyr-ethyl)、四氟丙酸(flupropanate)、氟胺草唑(flupoxame)、丙炔氟草胺(flumioxazin)、氟烯草酸(flumiclorac-pentyl)、唑嘧磺草胺(flumetsulam)、氟啶草酮(fluridone)、呋草酮(flurtamone)、氯氟吡氧乙酸(fluroxypyr)(包括例如氯氟吡氧乙酸丁氧基丙酯或氯氟吡氧乙酸异辛酯的酯、钠盐、钙盐或氨盐等)、氟咯草酮(flurochloridone)、丙草胺(pretilachlor)、丙苯磺隆钠盐(procarbazone-sodium)、氨基丙氟灵(prodiamine)、氟磺隆(prosulfuron)、苄草丹(prosulfocarb)、普拔草(propaquizafop)、毒草胺(propachlor)、普拔根(propazine)、除草灵(propanil)、戊炔草胺(propyzamide)、异丙草胺(propisochlor)、丙嗪嘧磺隆(propyrisulfuron)、苯胺灵(propham)、氟唑草胺(profluazol)、调环酸钙(prohexadione-calcium)、丙苯磺隆(propoxycarbazone)、丙苯磺隆钠盐(propoxycarbazone-sodium)、环苯草酮(profoxydim)、除草定(bromacil)、溴莠敏(brompyrazon)、扑草净(prometryn)、扑灭通(prometon)、溴苯腈(bromoxynil)(包括丁酸酯、辛酸酯或庚酸酯)、杀草全(bromofenoxim)、溴丁酰草胺(bromobutide)、双氟磺草胺(florasulam)、氯氟吡啶酯(florpyrauxifen)、苯甲基氯氟吡啶酯(florpyrauxifen-benzyl)、环嗪酮(hexazinone)、烯草胺(pethoxamid)、草除灵(benazolin)、平速烂(penoxsulam)、胺苯吡菌酮(heptamaloxyloglucan)、氟丁酰草胺(beflubutamid)、氟丁酰草胺M(beflubutamid-M)、克草猛(pebulate)、壬酸(pelargonic acid)、酰苯草酮(bencarbazone)、二甲戊灵(pendimethalin)、双苯嘧草酮(benzfendizone)、地散磷(bensulide)、免速隆(bensulfuron-methyl)、双环磺草酮(benzobicyclon)、吡草酮(benzofenap)、本达隆(bentazone)、甲氯酰草胺(pentanochlor)、环戊恶草酮(pentoxazone)、氟草胺(benfluralin)、呋草黄(benfuresate)、调节膦(fosamine)、氟磺胺草醚(fomesafen)、双氟磺草胺(foramsulfuron)、氯吡脲(forchlorfenuron)、二甲四氯丙酸(mecoprop)(包括钠盐、钾盐、异丙胺盐、三乙醇胺盐、二甲胺盐等)、精二甲四氯丙酸钾盐(mecoprop-P-potassium)、甲磺胺磺隆(mesosulfuron)(包括甲酯等)、硝磺草酮(mesotrione)、吡唑草胺(metazachlor)、嗪吡嘧磺隆(metazosulfuron)、噻唑隆(methabenzthiazuron)、苯嗪草酮(metamitron)、唑酰草胺(metamifop)、威百亩(metam)、甲基砷酸二钠(DSMA)、异唑啉(methiozolin)、苯丙隆(methyldymuron)、甲氧隆(metoxuron)、磺草唑胺(metosulam)、甲磺隆(metsulfuron-methyl)、溴谷隆(metobromuron)、吡喃隆(metobenzuron)、莫多草(metolachlor)、灭必净(metribuzin)、缩节胺(mepiquat chloride)、苯噻草胺(mefenacet)、单嘧磺隆(monosulfuron)(包括甲酯、乙酯、异丙酯)、绿谷隆(monolinuron)、禾草敌(molinate)、碘磺隆(iodosulfuron)、碘甲磺隆钠盐(iodosulfulon-methyl-sodium)、碘芬磺隆(iofensulfuron)、碘芬磺隆钠(iofensulfuron-sodium)、乳氟禾草灵(lactofen)、兰蔻三酮(lancotrione)、利谷隆(linuron)、砜嘧磺隆(rimsulfuron)、环草定(lenacil)、2,2,2-三氯乙酸(TCA)(包括钠盐、钙盐或氨盐等)、2,3,6-三氯苯甲酸(2,3,6-TBA)、2,4,5-三氯苯氧基乙酸(2,4,5-T)、2,4-二氯苯氧基乙酸(2,4-D)(包括胺盐、二乙胺盐、三乙醇胺盐、异丙胺盐、钠盐或锂盐等)、2-氨基-3-氯-1,4-萘醌(ACN)、2-甲基-4-氯苯氧乙酸(MCPA)(包括钠盐、乙酯等)、2-甲基-4-氯苯氧基乙酸(MCPB)(包括钠盐、乙酯等)、4-(2,4-二氯苯氧基)丁酸(2,4-DB)、4,6-二硝基-邻甲酚(DNOC)(包括胺盐、钠盐等)、AE-F-150944(代码编号)、IR-6396(代码编号)、2甲4氯硫代乙酯(MCPA-thioethyl)、SYP-298(代码编号)、SYP-300(代码编号)、S-乙基二丙基硫代氨基甲酸酯(EPTC)、S-异丙甲草胺(S-metolachlor)、S-9750(代码编号)、MSMA(MSMA)、HW-02(代码编号)。
植物生长调节剂:
1-萘乙酰胺、1-甲基环丙烯、2,6-二异丙基萘、4-氧代-4-(2-苯基乙基)氨基丁酸(化学名,CAS登录号:1083-55-2)、4-氯苯氧基乙酸(4-CPA)、正癸醇、艾维激素(aviglycine)、嘧啶醇(ancymidol)、脱落酸(abscisic acid)、抗倒胺(inabenfide)、吲哚乙酸、吲哚丁酸、烯效唑(uniconazole)、烯效唑-P(uniconazole-P)、Ecolyst、吲熟酯(ethychlozate)、乙烯利(ethephon)、丙酰芸苔素内酯(epocholeone)、8-羟基喹啉硫酸盐(oxine-sulfate)、香芹酮(carvone)、甲酸钙(calcium formate)、座果酸(cloxyfonac)、座果酸钾(cloxyfonac-potassium)、调果酸(cloprop)、矮壮素(chlormequat)、胆碱(choline)、细胞分裂素(cytokinins)、环丙酸酰胺(cyclanilide)、调呋酸(dikegulac)、赤霉素(gibberellin acid)、噻节因(dimethipin)、杀雄啉(sintofen)、丁酰肼(daminozide)、噻苯隆(thidiazuron)、三十烷醇(triacontanol)、抗倒酯(trinexapac-ethyl)、多效唑(paclobutrazol)、石蜡、氟节胺(flumetralin)、呋嘧醇(flurprimidol)、芴丁酯(flurenol)、茉莉酸丙酯(prohydrojasmon)、调环酸钙(prohexadione-calcium)、胺苯吡菌酮(heptamaloxyloglucan)、苄基胺基嘌呤(benzylaminopurine)、吡效隆(forchlorfenuron)、马来酰肼、缩节胺(mepiquatchloride)、氟草磺(mefluidide)、过氧化钙。
接着,下面示出了可以混合或组合使用的已知减轻植物毒性的化合物的实例。
双苯唑酸(isoxadifen)、双苯唑酸乙酯(isoxadifen-ethyl)、解草腈(oxabetrinil)、解草酯(cloquintcet-mexyl)、增效磷(dietholate)、解草胺腈(cyometrinil)、二氯丙烯胺(dichlormid)、二环酮(dicyclonone)、环丙磺酰胺(cyprosulfamide)、1,8-萘二甲酸酐(1,8-Naphthalic Anhydride)、解草唑(fenchlorazole-O-ethyl)、解草啶(fenclorim)、解草唑(furilazole)、氟草肟(fluxofenim)、解草安(flurazole)、解草嗪(benoxacor)、美芬特(mephenate)、吡唑解草酸(mefenpyr)、吡唑解草酸乙酯(mefenpyr-ethyl)、吡唑解草酯二乙酯(mefenpyr-diethyl)、低级烷基取代苯甲酸、2,2-二氯-N-(1,3-二噁烷-2-基甲基)-N-(2-丙烯基)乙酰胺(PPG-1292)、2-二氯甲基-2-甲基-1,3-二噁烷(MG-191)、3-二氯乙酰基-2,2,5-三甲基-1,3-唑啶(R-29148)、4-二氯乙酰基-1-氧杂-4-氮杂螺[4.5]癸烷(AD-67)、MON4660(代码编号)、metcamifen、N1,N2-二烯丙基-N2-二氯乙酰甘氨酰胺(DKA-24)、TI-35(代码编号)。
以上述方式所构成的本发明的有害生物防治剂对于直翅目(Orthoptera)害虫、缨翅目(Thysanoptera)害虫、半翅目(Hemiptera)害虫、鞘翅目(Coleoptera)害虫、双翅目(Diptera)害虫、鳞翅目(Lepidoptera)害虫、膜翅目(Hymenoptera)害虫、弹尾目(Collembola)害虫、樱尾目(Thysanura)害虫、蜚蠊目(Blattodea)害虫、等翅目(Isoptera)害虫、啮虫目(Psocoptera)害虫、食毛目(Mallophage)害虫、虱目(Anoplura)害虫、植物寄生性螨类、植物寄生性线虫类、植物寄生性软体动物、以及诸如其他有害动物、不良动物、卫生害虫、寄生虫等有害生物呈现出优异的防治效果。作为这些有害生物,可以列举以下生物种。
直翅目害虫的实例包括:螽斯科的黑胫钩额草螽(Ruspolia lineosa)等、蟋蟀科的黄脸油葫芦(Teleogryllus emma)、梨片蟋(Truljalia hibinonis)等、蝼蛄科的东方蝼蛄(Gryllotalpa orientalis)、蝗虫科的小稻蝗(Oxya hyla intricate)、飞蝗(Locustamigratoria)、血黑蝗(Melanoplus sanguinipes)、殊种蝗(Melanoplus differentialis)、红足黑蝗(Melanoplus femurrubrum)等、锥头蝗科的长额负蝗(Atractomorpha lata)、蛣蟋科的日本纤蟋(Euscyrtus japonicus)、蚤蝗科的日本蚤蝗(Xya japonicus)等。
缨翅目害虫的实例包括:蓟马科的花蓟马(Frankliniella intonsa)、西花蓟马(Frankliniella occidentalis)、茶黄蓟马(Scirtothrips dorsalis)、棕榈蓟马(Thripspalmi)、葱蓟马(Thrips tabaci)、日本烟草蓟马(Thrips setosus)、温室蓟马(Heliothrips haemorrhoidalis)、稻蓟马(Stenchaetothrips biformis)等、管蓟马科的柿管蓟马(Ponticulothrips diospyrosi)、山葵管蓟马(Liothrips wasabiae)、稻管蓟马(Haplothrips aculeatus)等。
半翅目害虫的实例包括:蝉科(Cicadidae)的姬草蝉(Mogannia minuta)等、沬蝉科(Aphrophoridae)的柳沫蝉(Aphrophora intermedia)等、角蝉科(Membracidae)的脊角蝉(Machaerotypus sibiricus)等、叶蝉科(Cicadellidae)的葡萄浮尘子(Arboridiaapicalis)、茶小绿叶蝉(Empoasca onukii)、伪黑尾叶蝉(Nephotettix cincticeps)、马来亚黑尾叶蝉(Nephotettix malayanus)、二点黑尾叶蝉(Nephotettix virescens)、黑条黑尾叶蝉(Nephotettix nigropictus)、电光叶蝉(Recilia dorsalis)、Okura叶禅(Amrascabiguttula)、芒果叶蝉(柠果褐叶蝉(Idioscopus nitidulus)、柠果绿叶禅(Idioscopusclypealis)、芒果额氏叶蝉(Amritodus atkinsoni))、电光叶蝉(Recilia dorsalis)、马铃薯小绿叶蝉(Empoasca fabae)、菱蜡蝉科(Cixiidae)的端斑五胸脊菱蜡蝉(Pentastiridius apicalis)等、稻虱科(Delphacidae)的灰飞虱(Laodelphaxstriatellus)、褐飞虱(Nilaparvata lugens)、白背飞虱(Sogatella furcifera)等、缟飞虱科(Meenoplidae)的缟飞虱(Nisia nervosa)等、长翅飞虱科(Derbidae)的佐藤斑飞虱(Kamendaka saccharivora)等、小头飞虱科(Cixidia)的Achilus flammeus等、广翅蜡蝉科(Ricaniidae)的条纹广翅蜡蝉(Orosanga japonicus)等、青翅飞虱科(Flatidae)的蛾蜡蝉(Mimophantia maritima)等、木虱科(Psyllidae)的梨木虱(Cacopsylla pyrisuga)、柑橘木虱(Diaphorina citri)等、丽木虱科的檬果丽木虱(Calophya mangiferae)等、根瘤蚜科(Phylloxeridae)的葡萄根瘤蚜(Daktulosphaira vitifoliae)等、球蚜科(Adelgidae)的落叶松球蚜(Adelges laricis)、铁杉球蚜(Adelges tsugae)等、蚜科(Aphydidae)的豌豆蚜(Acyrthosiphon pisum)、棉蚜(Aphis gossypii)、卷叶蚜(Aphis spiraecola)、伪菜蚜(Lipaphis erysimi)、甘蓝蚜(Brevicoryne brassicae)、桃蚜(Myzuspersicae)、麦二叉蚜(Schizaphis graminum)、禾谷缢管蚜(Rhopalosiphum padi)、小桔蚜(Toxopteraaurautii)、茄粗额蚜(Aulacorthum solani)、马铃薯长管蚜(Macrosiphum euphorbiae)、莴苣蚜(Nasonovia ribisnigri)、麦长管蚜(Sitobion avenae)、大豆蚜(Aphis glycines)等、粉虱科(Aleyrodidae)的茶刺粉虱(Aleurocanthus camelliae)、黑刺粉虱(Aleurocanthus spiniferus)、烟草粉虱(Bemisia tabaci)、银叶粉虱(Bemisiaargentifolii)、温室粉虱(Trialeurodes vaporariorum)等、绵蚧科(Margarodidae)的草履蚧(Drosicha corpulenta)、吹绵蚧(Icerya purchasi)等、粉蚧科(Pseudococcidae)的菠萝粉蚧(Dysmicoccus brevipes)、桔臀纹粉蚧(Planococcus citri)、康氏粉蚧(Pseudococcus comstocki)等、蚧科(Coccidae)的角蜡蚧(Ceroplastes ceriferus)、红蜡蚧(Ceroplastes rubens)等、仁蚧科的(Aclerdidae)的甘蔗仁蚧(Aclerda takahashii)等、盾蚧科(Diaspididae)的橘红肾圆盾蚧(Aonidiella aurantii)、梨枝圆盾蚧(Diaspidiotus perniciosus)、桑白盾蚧(Pseudaulacaspis pentagoa)、矢尖蚧(Unaspisyanonensis)等、盲蝽科(Miridae)的牧草盲蝽(Lygus lineolaris)、赤须盲蝽(Trigonotylus caelestialium)、绿盲蝽(Apolygus lucorum)、烟盲椿(Nesidiocoristenuis)、庭园盲蝽(Halticus bractatus)等、网蝽科(Tingidae)的杜鹃冠网蝽(Stephanitis pyrioides)、梨冠网蝽(Stephanitis nashi)等、蝽科(Pentatomidae)的皱纹菜蝽(Eurydema rugosum)、日本二星蝽(Eysarcoris lewisi)、北二星蝽(Eysarcorisaeneus)、稻椿象(Lagynotomus elongatus)、稻绿蝽(Nezara viridula)、小珀蝽(Plautiacrossota)、东方稻绿蝽(Nezara antennata)、褐蝽(Eushistus heros)等、龟蝽科(Plataspidae)的筛豆龟蝽(Megacopta cribraria)等、异蝽科(Urostylididae)的花壮异蝽(Urochela luteovoria)等、长蝽科(Lygaeidae)的甘蔗异背长蝽(Caveleriussaccharivorus)等、束长蝽科(Malcidae)的日本束长蝽(Malcus japonicus)等、红蝽科(Pyrrhocoridae)的棉二点红蝽(Dysdercus cingulatus)等、蛛缘蝽科(Alydidae)的异稻缘蝽(Leptocorisa acuta)、中稻缘蝽(Leptocorisa chinensis)等、缘蝽科(Coreidae)的纹须类同缘蝽(Anacanthocoris striicornis)等、姬缘蝽科(Rhopalidae)的黄伊缘蝽(Rhopalus maculatus)等、臭虫科(Cimicidae)的温带臭虫(Cimex lectularis)等。
鞘翅目害虫的实例包括:金龟子科(Scarabaeidae)的铜色丽金龟(Anomaracuprea)、红铜丽金龟(Anomara rufocuprea)、豆金龟(Popillia japonica)、小青花金龟(Oxycetonia jucunda)、樱桃小丽金龟(Anomala geniculata)、椰子犀角金龟(Oryctesrhinoceros)、茶色长金龟(Heptophylla picea)等、叩甲科(Elateridae)的细胸金针虫(Agriotes ogurae)、具条叩甲(Agriotes lineatus)、黑叩甲(Agriotes obscurus)、筛胸梳爪叩甲(Melanotus okinawensis)、褐纹金针虫(Melanotus fortnumi)等、皮蠹科(Dermestidae)的小圆皮蠹(Anthrenus verbasci)等、长蠹虫科(Bostrychidae)的二突异翅长蠹(Heterobostrychus hamatipennis)等、窃蠹科(Anobiidae)的药材甲(Stegobiumpaniceum)等、蛛甲科(Ptinidae)的棕蛛甲(Pitinus clavipes)等、谷盗科(Trogossitidae)的大谷盗(Tenebroides mauritanicus)等、郭公虫科(Cleridae)的赤足郭公虫(Necrobia rufipes)、露尾甲科(Nitidulidae)的酱曲露尾甲(Carpophilushemipterus)、油菜花露尾甲(Meligethes aeneus)等、锯谷盗科(Silvanidae)的米扁虫(Ahasverus advena)等、扁谷盗科(Laemophloeidae)的锈赤扁谷盗(Cryptolestesferrugineus)等、瓢虫科(Coccinellidae)的墨西哥豆瓢虫(Epilachna varivestis)、茄二十八星瓢虫(Henosepilachna vigintioctopunctata)等、拟步甲科(Tenebrionidae)的黄粉甲(Tenebrio molitor)、赤拟谷盗(Tribolium castaneum)等、芫菁科(Meloidae)的豆芫菁(Epicauta gorhami)等、天牛科(Cerambycidae)的光肩星天牛(Anoplophoraglabripennis)、葡萄虎天牛(Xylotrechus pyrrhoderus)、松墨天牛(Monochamusalternatus)、大豆蛀心虫(Dectes texanus)等、豆象科(Bruchidae)的绿豆象(Callosobruchus chinensis)等、金花虫科(Chrysomelidae)的科罗拉多金花虫(Leptinotarsa decemlineata)、西方玉米根虫(Diabrotica virgifera virgifera)、北方玉米根虫(Diabrotica barberi)、南方玉米根虫(Diabrotica undecimpunctatahowardi)、黄守瓜(Aulacophora femoralis)、甘蓝金花虫(Phaedon brassicae)、甜菜大龟甲(Cassida nebulosa)、稻负泥虫(Oulema oryzae)、墨西哥豆瓢虫(Epilachnavarivestis)、黄条叶蚤(Phyllotreta striolata)、茶肖叶甲(Demotina fasciculata)、油菜兰跳甲(Psylliodes chrysocephala)、豆叶甲(Cerotoma trifurcate)、葡萄肖叶甲(Colaspis brunnea)、Colaspis crinnicornis、大豆潜叶虫(Odontota horni)、玉米跳甲(Chaetocnema pulicaria)等、三锥象鼻虫科(Brentidae)的甘薯蚁象(Cylasformicarius)等、象鼻虫科(Curculionidae)的苜蓿象鼻虫(Hypera postica)、蔬菜象鼻虫(Listroderes costirostris)、甘薯象鼻虫(Euscepes postfasciatus)、栗果象鼻虫(Curculio sikkimensis)等、粗吻象鼻虫科(Erirhinidae)的稻象鼻虫(Echinocnemusbipunctatus)、水稻水象鼻虫(Lissorhoptrus oryzophilus)、南美洲水稻水象鼻虫(Oryzophagus oryzae)等、步行象鼻虫科(Dryophthoridae)的玉米象(Sitophiluszeamais)、狩猎象鼻虫(Sphenophrus venatus)等、小蠹科(Scolytidae)的纵坑切梢小蠹(Tomicus piniperda)等、长小蠹虫科(Platypodidae)的台日截尾长小蠹(Crossotarsusniponicus)等、粉蠹科(Lyctidae)的褐粉蠹(Lyctus brunneus)等。
双翅目害虫的实例包括:大蚊科的稻大蚊(Tipula aino)等、毛蚊科的黑色小毛蚊((Plecia nearctica)等、蕈蝇科的Exechia shiitakevora等、黑翅蕈蚋科的马铃薯蕈蚊(Pnyxiascabiei)、库拓果实蝇(Bradysia agrestis)等、瘿蚋科的大豆荚瘿蚊(Asphondylia yushimai)、小麦瘿蚊(Mayetiola destructor)、越橘瘿蚊(Dasineuraoxycoccana)等、蚊科的埃及伊蚊(Aedes aegypti)、淡色库蚊(Culex pipiens pallens)等、蚋科的素木蚋(Simulium takahashii)等、摇蚊科的稻摇蚊(Chironomus oryzae)等、虻科的盲虻(Chrysops suavis)、三角虻(Tabanus trigonus)等、食蚜蝇科的洋葱平颜食蚜蝇(Eumerus strigatus)等、实蝇科的东方果实蝇(Bactrocera dorsalis)、日本樱桃果实蝇(Euphranta japonica)、地中海果实蝇(Ceratitis capitata)等、潜蝇科的非洲菊斑潜蝇(Liriomyza trifolii)、美洲斑潜蝇(Liriomyza sativae)、日本稻潜蝇(Agromyzaoryzae)、番茄斑潜蝇(Liriomyza bryoniae)、豌豆彩潜蝇(Chromatomyia horticola)、葱斑潜蝇(Liriomyza chinensis)、非洲菊斑潜蝇(Liriomyza trifolii)等、秆蝇科的黑腹麦秆蝇(Meromyza nigriventris)等、果蝇科的斑翅果蝇(Drosophila suzukii)、黑腹果蝇(Drosophila melanogaster)等、水蝇科的水稻潜叶蝇(Hydrellia griseola)等、虱蝇科的马虱蝇(Hippobosca equina)等、粪蝇科的笹川粪蝇(Parallelpmma sasakawae)等、花蝇科的葱蝇(Delia antiqua)、灰地种蝇(Delia platura)等、厕蝇科的夏厕蝇(Fanniacanicularis)等、家蝇科的家蝇(Musca domestica)、厩螫蝇(Stomoxys calcitrans)等、麻蝇科的棕尾别麻蝇(Sarcophaga peregrina)等、胃蝇科的肠胃蝇(Gasterophilusintestinalis)等、皮蝇科的纹皮蝇(Hypoderma lineatum)等、狂蝇科的羊狂蝇(Oestrusovis)等。
鳞翅目害虫的实例包括:蝠蛾科的淡缘蝠蛾(Endoclita excrescens)等、日蛾科的葡萄果蠹蛾(Antispila ampelopsia)等、蠹蛾科的六星黑点豹蠹蛾(Zeuzeraleuconotum)、芳香木蠹蛾(Cossus insularis)等、卷叶蛾科的乱纹苹果卷叶蛾(Archipsfuscocupreanus)、苹果粉角纹卷叶蛾(Adoxophyes orana fasciata)、梨小食心虫(Grapholita molesta)、茶卷叶蛾(Homona magnanima)、大豆食心虫(Leguminivoraglycinivorella)、苹果蠹蛾(Cydia pomonella)、葡萄花翅小卷蛾(Lobesia botrana)等、纹蛾科的葡萄与苹果卷叶蛾(Eupoecilia ambiguella)等、蓑蛾科的蓑蛾(Bambalinasp.)、茶避债蛾(Eumeta minuscula)等、蕈蛾科的谷蛾(Nemapogon granella)、衣蛾(Tineatranslucens)等、棱巢蛾科的潜蛾(Bucculatrix pyrivorella)等、莱氏蛾科的桃潜叶蛾(Lyonetia clerkella)、银纹潜叶蛾(Lyonetiaprunifoliella malinella)等、细蛾科的茶细蛾(Caloptilia theivora)、苹果金纹细蛾(Phyllonorycter ringoniella)等、潜叶蛾科的柑橘潜叶蛾(Phyllocnistis citrella)等、伪菜蛾科(Acrolepiidae)的葱菜蛾(Acrolepiopsis sapporensis)等、菜蛾科的小菜蛾(Plutella xylostella)、巢蛾科的苹果巢蛾(Yponomeuta orientalis)等、银蛾科的苹果银蛾(Argyresthia conjugella)等、透翅蛾科的葡萄透翅蛾(Nokona regalis)、苹果透翅蛾(Synanthedin hector)等、旋蛾科的马铃薯蠹蛾(Phthorimaea operculella)、麦蛾(Sitotroga cerealella)、棉红铃虫(Pectinophora gossypiella)、番茄潜麦蛾(Tuta absoluta)等、果蛀蛾科的桃蛀果蛾(Carposina sasakii)等、斑蛾科的梨叶斑蛾(Illiberis pruni)等、刺蛾科的黄刺蛾(Monema flavescens)等、草螟科的稻巢草螟(Ancylolomia japonica)、二化螟(Chilosuppressalis)、稻纵卷叶螟(Cnaphalocrocis medinalis)、亚洲玉米螟(Ostriniafurnacalis)、菜心螟(Hellulla undalis)、桃蛀螟(Conogethes punctiferlis)、瓜绢野螟(Diaphania indica)、早熟禾拟茎草螟(Parapediasia teterrella)、欧洲玉米螟(Ostrinia nubilalis)等、螟蛾科的小蔗螟(Diatraea saccharalis)、粉斑螟蛾(Cadracautella)、蜡螟(Galleria mellonella)等、羽蛾科的小葡萄羽蛾(Nippoptilia vitis)等、凤蝶科的柑桔凤蝶(Papilio xuthus)等、粉蝶科的纹白蝶(Pieris rapae)等、弄蝶科的稻弄蝶(Parnara guttata)等、尺蛾科的肾斑尺蛾(Ascotis selenaria)等、枯叶蛾科的赤松毛虫(Dendrolimus spectabilis)、带枯叶蛾(Malacosoma neustrium testaceum)等、天蛾科的白薯天蛾(Agrius convolvuli)等、毒蛾科的茶毒蛾(Arna pseudoconspersa)、方定古毒蛾(Orygia recens approximans)、舞毒蛾(Lymantria dispar)等、灯蛾科的美国白蛾(Hyphantria cunea)等、夜蛾科的球菜夜蛾(Agrotis ipsilon)、黄地老虎(Agrotissegetum)、黑点银纹夜蛾(Autographa nigrisigna)、棉铃实夜蛾(Helicoverpaarmigera)、棉铃虫(Helicoverpa zea)、烟芽夜蛾(Heliothis virescens)、甜菜夜蛾(Spodoptera exigua)、斜纹夜蛾(Spodoptera litura)、大豆尺夜蛾(Chrysodeixincludens)、草地贪夜蛾(Spodoptera frugiperda)、铜色夜蛾(Nephelodes minians)等。
膜翅目害虫的实例包括:三节叶蜂科的玫瑰三节叶蜂(Arge pagana)等、叶蜂科的栗叶蜂(Apethymus kuri)、黄翅菜叶蜂(Athalia rosae ruficornis)等、瘿蜂科的栗瘿蜂(Dryocosmus kuriphilus)等、胡蜂科的黄色胡蜂(Vespa simillima xanthoptera)等、蚁科的红火蚁(Solenopsis invicta)、阿根廷蚁(Linepithema humile)等、切叶蜂科的月季切叶蜂(Megachile nipponica)等。
弹尾目害虫的实例包括:圆跳虫科的黄星圆跳虫(Bourletiella hortensis)等。
缨尾目害虫的实例包括:衣鱼科的衣鱼(Lepisma saccharina)、毛衣鱼(Ctenolepisma villosa)等。
蜚蠊目害虫的实例包括:蜚蠊科的美洲大蠊(Periplaneta americana)、姬蠊科的德国小蠊(Blattella germanica)、白蚁科的台湾土白蚁(Odontotermes formosanus)、木白蚁科的小楹白蚁(Incisitermes minor)、截头堆砂白蚁(Cryptotermes domesticus)、犀白蚁科的台湾乳白蚁(Coptotermes formosanus)、栖北散白蚁(Reticulitermessperatus)等。
啮虫目害虫的实例包括:节啮虫科的粉茶蛀虫(Trogium pulsatorium)等、虱啮科的啮虫(Liposcelis corrodens)等。
革翅目害虫的实例包括:球蠼螋科的蠼螋(Labodura riparia)等。
食毛目害虫的实例包括:短角鸟虱科的鸡长角鸟虱(Lipeurus caponis)、兽羽虱科的牛毛虱(Damalinia bovis)等等。
虱目害虫的实例包括:兽虱科的猪虱(Haematopinus suis)等、虱科的人虱(Pediculus humanus)等、毛虱科的狗虱(Linognathus setosus)等、阴虱科的阴虱(Pthirus pubis)等。
壁虱目害虫的实例包括:走螨科的麦圆蜘蛛(Penthaleus major)等、跗线螨科的樱草植食螨(Phytonemus pallidus)、茶黄螨(Polyphagotarsonemus latus)等、蒲螨科的蒲螨(Siteroptes sp.)中的一种等、细须螨科的葡萄短须螨(Brevipalpus lewisi)等、杜克螨科的孔雀杜克螨(Tuckerella pavoniformis)等、叶螨科的北始叶螨(Eotetranychusboreus)、柑橘全爪螨(Panonychus citri)、榆全爪螨(Panonychus ulmi)、二点叶螨(Tetranychus urticae)、神泽氏叶螨(Tetranychus kanzawai)等、纳氏瘿螨科的松三毛瘿螨(Trisetacus pini)等、瘿螨科的桔刺皮节蜱(Aculops pelekassi)、梨上瘿螨(Epitrimerus pyri)、柑橘锈螨(Phyllocoptruta oleivora)、番茄刺皮瘿螨(Aculopslycopersici)等、羽爪瘿螨科的冻绿双羽爪瘿螨(Diptacus crenatae)等、粉螨科的椭圆食粉螨(Aleuroglyphus ovatus)、腐食酪螨(Tyrophagus putrescentiae)、罗宾根螨(Rhizoglyphus robini)、瓦螨科的雅氏瓦螨(Varroa jacobsoni)等、皮刺螨科的鸡皮刺螨(Dermanyssus gallinae)等、巨刺螨科的林禽刺螨(Ornithonyssus sylvialum)等、硬蜱科的微小扇头蜱(Boophilus microplus)、血红扇头蜱(Rhipicephalus sanguineus)、长角血蜱(Haemaphysalis longicornis)等、疥螨科的人疥螨(Sarcoptes scabiei)等。
植物寄生性线虫类的实例包括:长针科的剑线虫(Xiphinema index)等、毛刺科的较小拟毛刺线虫(Paratrichodorus minor)等、小杆科的一种(Rhabditella sp.)等、垫刃科的一种(Aglenchus sp.)等、锥垫刃科的一种(Cephalenchus sp.)等、粒线虫科的草莓线虫(Nothotylenchus acris)、马铃薯腐败线虫(Ditylenchus destructor)等、纽带科的肾形线虫(Rotylenchulus reniformis)、双宫螺旋线虫(Helicotylenchus dihystera)等、针科的弯曲短体线虫(Paratylenchus curvitatus)等、根结线虫科的南方根结线虫(Meloidogyne incognita)、北方根结线虫(Meloidogyne hapla)、爪哇根结线虫(Meloidogyne javanica)、花生根结线虫(Meloidogyne arenaria)、奇氏根结线虫(Melidogyne chitwoodi)、伪根结线虫(Meloidogyne fallax)等、异皮科的黄金线虫(Globodera rostochiensis)、马铃薯白线虫(Globodera pallida)、大豆胞囊线虫(Heterodera glycines)等、端垫刃科的克莱顿矮化线虫(Tylenchorhynchus claytoni)等、裸毛科的一种(Psilenchus sp.)等、环科的一种(Criconemoides sp.)等、半穿刺科的柑橘半穿刺线虫(Tylenchulus semipenetrans)等、球线虫科的山茶球线虫(Sphaeronemacamelliae)等、短体科的山茶球线虫(Sphaeronema camelliae)、柑橘穿孔线虫(Radopholus citrophilus)、香蕉穿孔线虫(Radopholus similis)、异常珍珠线虫(Nacobbus aberrans)、穿刺根腐线虫(Pratylenchus penetrans)、咖啡短体线虫(Pratylenchus coffeae)、玉米短体线虫(Platylechus zeae)、短尾根腐线虫(Platylenchus brachyurus)等、小齿线虫科的伞菌糟瘤线虫(Iotonchium ungulatum)等、滑刃科的真滑刃线虫(Aphelenchus avenae)等、拟滑刃科的水稻干尖线虫(Aphelenchoides besseyi)、草莓滑刃线虫(Aphelenchoides fragariae)等、寄生滑刃科的松材线虫(Bursaphelenchus xylophilus)等。
植物寄生性软体动物的实例包括:瓶螺科的福寿螺(Pomacea canaliculata)等、皱足蛞蝓科的皱足蛞蝓(Leavicaulis alte)等、非洲大蜗牛科的非洲大蜗牛(Achatinafulica)等、嗜黏液蛞蝓科的双线蛞蝓(Meghimatium bilineatum)等、琥珀螺科的锥实蜗牛(Succinealauta)等、圆盘蜗牛科的浅圆盘螺(Discus pauper)等、带螺科的虾夷琥珀贝(Zonitoides yessoensis)等、蛞蝓科的黄蛞蝓(Limax flavus)、瓦仑西亚列蛞蝓(Lehmannia valentiana)、网纹野蛞蝓(Deroceras reticulatum)等、鳖甲蜗牛科的鳖甲蜗牛(Parakaliella harimensis)等、巴蜗牛科的薄皮蜗牛(Acusta despectasieboldiana)、同型巴蜗牛(Bradybaena similaris)等。
其他有害动物、不良动物、卫生害虫、家畜害虫、寄生虫等有害生物的实例包括:十足目正螯虾科的克氏原螯虾(Procambarus clarkii)等、等足目鼠妇科的鼠妇虫(Porcellio scaber)等、卷壳虫科的球鼠妇虫(Armadillidium vulgare)等、蚰蜒目蚰蜒科的蚰蜒及蜈蚣目少棘蜈蚣(Scolopendra subspinipes)等唇足亚纲害虫、带马陆目奇马陆科的温室马陆(Oxidus gracilis)等倍足纲害虫、蜘蛛目姬蛛科的赤背寡妇蛛(Theridiidae hasseltii)等、蜘蛛目袋蛛科的日本红螯蛛(Chiracanthium japonicum)等、蝎目的土耳其黑肥尾蝎(Androctonus crassicauda)等、线形动物内部寄生虫的蛔虫(Ascaris lumbricoides)等、管状线虫(Syphacia sp.)等、班氏丝虫类(Wuchereriabancrofti)等、扁形动物内部寄生虫的肝蛭(Distomum sp.)、卫氏肺吸虫(Paragonimuswestermanii)、横川吸虫(Metagonimus yokokawai)、日本血吸虫(Schistosomajaponicum)、猪带绦虫(Taenia solium)、牛带绦虫(Taeniarhynchus saginatus)、包生绦虫属(Echinococcus sp.)、阔节裂头绦虫(Diphyllobothrium latum)等。
对于已对现有的有害生物防治剂具有抵抗性的上述所例示的有害生物等,本发明的有害生物防治剂也呈现出防治效果。此外,本发明的有害生物防治剂也可用于因基因重组、人工交配等而获得害虫耐性、病害耐性、除草剂耐性等特性的植物。
本发明的“因育种法或基因重组技术而被赋予了耐性的植物”包括因组合分子生物学技术与目前现有的交配技术而成的新育种技术(NBTs)而赋予耐性的植物,以及因经典的品种交配而赋予耐性或因基因重组技术而赋予耐性的植物。新育种技术(NBTs)记载于出版物“Atarashii syokubutu ikusyu wo rikaishiyo”(Kokusai bunken sha,Ryo OSAWA和Hiroshi EZURA著)、综述“Genome Editing Tools in Plants”(Genes 2017,8,399,由Tapan Kumar Mohanta、Tufail Bashir、Abeer Hashem、Elsayed Fathi Abd_Allah和Hanhong Bae著)等中。
接着,以下述实施例详细说明本发明化合物的制造方法、配制方法以及用途。然而,本发明并不受这些实施例的任何限制。使用Yanaco制MP-500V微量熔点测量装置测量作为本发明化合物的物理性质值的熔点。使用ATAGO制阿贝折射计测量折射率。1H NMR光谱为使用JEOL Ltd.制JNM-LA400(400MHz)、JNM-LA300(300MHz)或JNM-ECS300(300MHz),以四甲基硅烷(TMS)作为内标进行测量的。
此外,还描述了制备本发明化合物的制造中间体的方法。
实施例
[实施例1]
1-(吡啶-3-基)-4-[2-(三氟甲基)苯基]-1H-吡唑-3-羧酰胺(本发明化合物编号:A-0044)的制造
1)4-{[(九氟丁基)磺酰基]氧基}-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(本发明化合物编号:D-0008)
将通过WO 2016/027790A的参考例1及2记载的方法所合成的4-羟基-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(15.0g、64.3mmol)、三乙胺(13.0g、128.5mmol)以及九氟丁磺酸氟化物(27.2g、90.0mmol)依次添加到冰冷下的二氯甲烷(300mL)中,在室温下搅拌过夜。将反应溶液注入饱和盐水中,并以二氯甲烷进行萃取。用无水硫酸镁使所得到的有机层干燥后,减压蒸馏除去溶剂。用二异丙醚清洗残留物而得到4-{[(九氟丁基)磺酰基]氧基}-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(29.0g、产率:88%)。
熔点:103℃-104℃
1H-NMR数据(400MHz,CDCl3/TMSδ(ppm)):1.44(3H,t),4.50(2H,q),7.48(1H,dd),8.08(1H,s),8.15(1H,dd),8.70(1H,d),8.99(1H,d)
2)1-(吡啶-3-基)-4-(2-(三氟甲基)苯基)-1H-吡唑-3-羧酸乙酯(本发明化合物编号:C-0044)
将4-{[(九氟丁基)磺酰基]氧基}-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(4.0g、7.8mmol)、2-(三氟甲基)苯硼酸(2.4g、12.6mmol)、碳酸钠(2.7g、25.5mmol)和四(三苯基膦)钯(0.45g、0.39mmol)添加到四氢呋喃(30mL)以及水(6mL)的混合溶剂中,并在氮气环境下进行加热回流5小时。反应结束后,将反应溶液注入饱和盐水中,并以乙酸乙酯进行萃取。用无水硫酸镁使所得到的有机层干燥后,减压蒸馏除去溶剂。通过硅胶柱色谱法对残留物进行纯化,得到1-(吡啶-3-基)-4-{2-(三氟甲基)苯基}-1H-吡唑-3-羧酸乙酯(2.6g、产率:93%)。
熔点:131℃-134℃
1H-NMR数据(400MHz,CDCl3/TMSδ(ppm)):1.13(3H,t),4.24(2H,q),7.30–7.70(4H,m),7.77(1H,d),7.98(1H,s),8.21(1H,ddd),8.65(1H,dd),9.04(1H,d)
3)1-(吡啶-3-基)-4-[2-(三氟甲基)苯基]-1H-吡唑-3-羧酰胺(本发明化合物编号:A-0044)
将1-(吡啶-3-基)-4-[2-(三氟甲基)苯基]-1H-吡唑-3-羧酸乙酯(2.5g、6.9mmol)溶解于乙醇(30mL),在室温下添加氢氧化钠(0.84g、21.0mmol)与水(5.0mL),再使用油浴将所得溶液加热至40℃并搅拌1小时。减压蒸馏除去该反应溶液的溶剂,向残留物中添加6N盐酸,滤出沉淀的固体,进行干燥,从而得到粗制的1-(吡啶-3-基)-4-[2-(三氟甲基)苯基]-1H-吡唑-3-羧酸。使所得到的1-(吡啶-3-基)-4-[2-(三氟甲基)苯基]-1H-吡唑-3-羧酸溶解于二氯甲烷(50mL),并添加草酰氯(5.9g、46.5mmol)以及N,N-二甲基甲酰胺(催化量),在室温下使其反应1小时。减压蒸馏除去溶剂,并使残留物溶解于四氢呋喃(10mL)。在0℃下将该溶液添加到四氢呋喃(20mL)与氨水(含量:28%、10mL)的混合溶液中,之后在室温下搅拌1小时。减压蒸馏除去该反应溶液的溶剂。用水和2-丙醇依次清洗残留物,并用氯仿使所得到的粗制生成物再结晶而得到1-(吡啶-3基)-4-[2-(三氟甲基)苯基]-1H-吡唑-3-羧酰胺(1.1g、产率:48%)。
熔点:178℃-181℃
1H-NMR data(400MHz,CDCl3/TMSδ(ppm)):5.34(1H,brs),6.79(1H,brs),7.44–7.61(4H,m),7.75(1H,d),7.96(1H,s),8.09(1H,dd),8.64(1H,d),9.04(1H,d)
[实施例2]
4-(4-甲基吡啶-3-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酰胺(本发明化合物编号:B-100)的制造
1)4-(4-甲基吡啶-3-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(本发明化合物编号:D-0108)
将4-{[(九氟丁基)磺酰基]氧基}-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(3.4g、6.6mmol)、4-(甲基吡啶-3-基)硼酸(1.0g、7.3mmol)、碳酸钠(1.6g、15.1mmol)和四(三苯基膦)钯(0.38g、0.33mmol)添加到1,2-二甲氧基乙烷(30mL)以及水(6mL)的混合溶剂中,并于氮气环境下进行加热回流9小时。反应结束后,将反应溶液注入饱和盐水中,并以乙酸乙酯进行萃取。用无水硫酸镁使所得到的有机层干燥后,减压蒸馏除去溶剂。通过硅胶柱色谱法对残留物进行纯化,得到4-(4-甲基吡啶-3-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(1.3g、产率:64%)。
熔点:120℃-123℃
1H-NMR数据(300MHz,CDCl3/TMSδ(ppm)):1.20(3H,t),2.24(3H,s),4.28(2H,q),7.21(1H,d),7.47(1H,dd),7.96(1H,s),8.21(1H,ddd),8.41(1H,s),8.48(1H,dd),8.65(1H,dd),9.05(1H,d)
2)4-(4-甲基吡啶-3-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸(本发明化合物编号:F-0108)
使4-(4-甲基吡啶-3-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(1.2g、3.9mmol)溶解于乙醇(15mL)中,在室温下添加氢氧化钠(0.47g、11.8mmol)和水(3.0mL),并搅拌1小时。减压蒸馏除去该反应溶液的溶剂,向残留物中添加6N盐酸,滤出沉淀的固体,用水和己烷进行清洗,并进行干燥,从而得到4-(4-甲基吡啶-3-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸(0.8g,产率:73%)。
熔点:277℃-280℃
1H-NMR数据(300MHz,DMSO-d6/TMSδ(ppm)):2.05(3H,s),7.29(1H,d),7.58(1H,dd),8.30(1H,dd),8.34(1H,s),8.39(1H,d),8.59(1H,d),8.80(1H,s),9.15(1H,d)
3)4-(4-甲基吡啶-3-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酰胺(本发明化合物编号:B-0100)
使4-(4-甲基吡啶-3-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸(0.20g、0.71mmol)溶解于N,N-二甲基甲酰胺(5.0mL)中,添加氯化铵(0.076g、1.4mmol)、1-羟基苯并三唑(0.12g、0.89mmol)、1-乙基-3-(3-二甲氨基丙基)碳二亚胺盐酸盐(0.20g、1.0mol)和三乙胺(0.15g、1.5mmol),在室温下使该混合物反应2小时。将该反应溶液注入饱和碳酸氢钠水溶液中,滤掉固体,并用水和正己烷依次进行清洗,得到4-(4-甲基吡啶-3-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酰胺(0.16g、产率:80%)。
熔点:264℃-267℃
1H-NMR数据(400MHz,DMSO-d6/TMSδ(ppm)):2.22(3H,s)7.30(1H,d),7.43(1H,brs),7.62(1H,dd),7.87(1H,brs),8.37(1H,s),8.38–8.45(2H,m),8.61(1H,d),8.80(1H,s),9.28(1H,d)
[实施例3]
4-(4-氯-2-甲氧基苯基)-1-(吡啶-3-基)-1H-吡唑-3-羧酰胺(本发明化合物编号:A-0634)的制造
1)4-(4-氯-2-甲氧基苯基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(本发明化合物编号:C-0634)
将4-{[(九氟丁基)磺酰基]氧基}-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(0.42g、0.82mmol)、4-氯-2-甲氧基苯硼酸(0.20g、1.1mmol)、碳酸钠(0.19g、1.8mmol)和四(三苯基膦)钯(0.050g、0.043mmol)添加到四氢呋喃(5.0mL)和水(0.50mL)的混合溶剂中,并于氮气环境下进行加热回流3小时。反应结束后,将反应溶液注入饱和盐水中,并以乙酸乙酯进行萃取。用无水硫酸镁使所得到的有机层干燥后,减压蒸馏除去溶剂。通过硅胶柱色谱法对残留物进行纯化,得到4-(4-氯-2-甲氧基苯基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(0.25g、产率:86%)。
熔点:133℃-134℃
1H-NMR数据(300MHz,CDCl3/TMSδ(ppm)):1.27(3H,t),3.78(3H,s),4.32(2H,q),6.94(1H,d),7.00(1H,dd),7.26(1H,d),7.44(1H,dd),7.99(1H,s),8.17(1H,ddd),8.61(1H,dd),9.02(1H,d)
2)4-(4-氯-2-甲氧基苯基)-1-(吡啶-3-基)-1H-吡唑-3-羧酰胺(本发明化合物编号:A-0634)
使4-(4-氯-2-甲氧基苯基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(0.15g、0.42mmol)溶解于7M的氨的甲醇溶液(20mL)中,在室温下搅拌2天。此外,向反应溶液中加入7M的氨的甲醇溶液(30mL),在室温下搅拌3天。减压蒸馏除去反应溶液的溶剂,通过硅胶柱色谱法对残留物进行纯化,得到4-(4-氯-2-甲氧基苯基)-1-(吡啶-3-基)-1H-吡唑-3-羧酰胺(0.12g、产率:87%)。
熔点:192℃-194℃
1H-NMR数据(300MHz,CDCl3/TMSδ(ppm)):3.81(3H,s),5.44(1H,brs),6.77(1H,brs),6.94(1H,d),6.99(1H,dd),7.40(1H,d),7.42-7.48(1H,m),8.05(1H,s),8.05-8.11(1H,m),8.57-8.67(1H,m),8.98-9.09(1H,m)
[实施例4]
4-碘-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(本发明化合物编号:D-0003)的制造
使1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(0.92g、4.2mmol)溶解于乙腈(10mL)中,添加碘(1.1g、4.3mmol)和硝酸铈(Ⅳ)铵(2.4g、4.3mmol)并进行加热回流10小时。反应结束后,向反应溶液中添加饱和硫代硫酸钠水溶液,并以乙酸乙酯进行萃取。用无水硫酸镁使所得到的有机层干燥后,减压蒸馏除去溶剂,通过硅胶柱色谱法对残留物进行纯化,得到4-碘-1-(吡啶-3基)-1H-吡唑-3-羧酸乙酯(0.75g、产率:52%)。
熔点128℃-130℃
1H-NMR数据(300MHz,CDCl3/TMSδ(ppm)):1.44(3H,t),4.47(2H,q),7.45(1H,dd),8.07(1H,s),8.10(1H,ddd),8.64(1H,dd),8.97(1H,d)
[实施例5]
3-[3-氨基甲酰基-4-(2-甲基苯基)-1H-吡唑-1-基]吡啶-1-氧化物(本发明化合物编号:A-8862)的制造
使1-(吡啶-3-基)-4-(2-甲基苯基)-1H-吡唑-3-羧酰胺(本发明化合物编号:A-0020;0.30g、1.1mmol)溶解于氯仿(50mL)中,添加间氯过氧苯甲酸(含量:77%、0.48g、2.1mmol)并进行加热回流2小时。反应结束后,减压蒸馏除去溶剂,通过硅胶柱色谱法对残留物进行纯化,得到3-[3-氨基甲酰基-4-(2-甲基苯基)-1H-吡唑-1-基]吡啶-1-氧化物(0.31g、产率:98%)。
1H-NMR数据(400MHz,CDCl3/TMSδ(ppm)):2.24(3H,s),5.39(1H,brs),6.63(1H,brs),7.23-7.34(4H,m),7.40(1H,dd),7.62(1H,d),7.84(1H,s),8.19(1H,d),8.81(1H,s)
[实施例6]
4-(3-甲基吡啶-2-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酰胺(本发明化合物编号:B-0027)的制造
1)4-(3-甲基吡啶-2-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(本发明化合物编号:D-0035)
使4-{[(九氟丁基)磺酰基]氧基}-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(3.1g、6.0mmol)、双(频哪醇)合二硼(bis(pinacolato)diboron)(2.3g、9.1mmol)、乙酸钾(1.8g、18.3mmol)和[1,1’-双(二苯基膦)二茂铁]二氯化钯二氯甲烷加成物(0.49g、0.60mmol)溶解于N,N-二甲基甲酰胺(60mL)中,在氮气环境下使用油浴加热至90℃并搅拌4小时。反应结束后,将反应溶液注入饱和盐水中,并以乙酸乙酯进行萃取。用无水硫酸镁使所得到的有机层干燥后,减压蒸馏除去溶剂。再采用硅胶柱色谱法,得到粗制的(3-(乙氧基羰基)-1-(吡啶-3-基)-1H-吡唑-4-基)硼酸。使所得到的(3-(乙氧基羰基)-1-(吡啶-3-基)-1H-吡唑-4-基)硼酸溶解于四氢呋喃(15mL)和水(3mL)的混合溶剂中,并添加2-溴-3-甲基吡啶(0.44g、2.6mmol)、碳酸钠(0.53g、5.0mmol)、四(三苯基膦)钯(0.25g、0.22mmol),在氮气环境下进行加热回流1小时。反应结束后,将反应溶液注入饱和盐水中,并以乙酸乙酯进行萃取。用无水硫酸镁使所得到的有机层干燥后,减压蒸馏除去溶剂。通过硅胶柱色谱法对残留物进行纯化,得到4-(3-甲基吡啶-2-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(0.74g、产率:40%)。
熔点:97℃-100℃
1H-NMR数据(400MHz,DMSO/TMSδ(ppm)):0.86(3H,t),2.25(3H,s),4.19(2H,q),7.31(1H,dd),7.64(1H,dd),7.71(1H,d),8.30-8.39(1H,m),8.40(1H,d),8.64(1H,d),8.90(1H,s),9.19(1H,d)
2)4-(3-甲基吡啶-2-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酰胺(本发明化合物编号:B-0027)
使4-(3-甲基吡啶-2-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸乙酯(0.69g、2.2mmol)溶解于乙醇(15mL)中,在室温下添加氢氧化钠(0.27g、6.8mmol)和水(3.0mL),并搅拌2小时。减压蒸馏除去该反应溶液的溶剂,使残留物溶解于水中,添加2N盐酸将pH调节为4至7。再于减压下蒸馏掉水,得到粗制的4-(3-甲基吡啶-2-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸。使所得到的4-(3-甲基吡啶-2-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酸溶解于N,N-二甲基甲酰胺(10mL),添加氯化铵(0.24g、4.5mmol)、1-羟基苯并三唑(0.36g、2.7mmol)、1-乙基-3-(3二甲氨基丙基)碳二亚胺盐酸盐(0.64g、3.3mol)和三乙胺(1.1g、10.9mmol),在室温下使其反应2小时。将该反应溶液注入饱和碳酸氢钠水溶液,并以乙酸乙酯进行萃取。用无水硫酸镁使所得到的有机层干燥后,减压蒸馏除去溶剂。向残留物中添加乙酸乙酯和己烷,并用乙酸乙酯和己烷对沉淀的固体进行清洗,得到4-(3-甲基吡啶-2-基)-1-(吡啶-3-基)-1H-吡唑-3-羧酰胺(0.11g、产率:18%)。
熔点:145℃-148℃
1H-NMR数据(400MHz,DMSO/TMSδ(ppm)):2.22(3H,s),7.28(1H,dd),7.40(1H,s),7.60(1H,dd),7.67(1H,d),7.90(1H,s),8.35-8.43(2H,m),8.60(1H,d),8.80(1H,s),9.27(1H,d)
[实施例7]
1-(吡啶-3-基)-4-(2-甲基苯基)-1H-吡唑-3-羰基氨基甲酸乙酯(本发明化合物编号:A-5414)的制造
使1-(吡啶-3-基)-4-(2-甲基苯基)-1H-吡唑-3-羧酰胺(本发明化合物编号:A-0020;0.50g、1.8mmol)溶解于草酰氯(15g、118mmol)中,并将所得溶液加热回流10分钟。减压蒸馏去除草酰氯,使残留物溶解于乙醇(7.9g、171mmol)中,并在室温下搅拌10分钟。反应结束后,将反应溶液注入饱和碳酸氢钠水溶液中,并以乙酸乙酯进行萃取。用无水硫酸镁使所得到的有机层干燥后,减压蒸馏除去溶剂。通过硅胶柱色谱法对残留物进行纯化,得到1-(吡啶-3-基)-4-(2-甲基苯基)-1H-吡唑-3-羰基氨基甲酸乙酯(0.18g、产率:29%)。
1H-NMR数据(300MHz,CDCl3/TMSδ(ppm)):1.40(3H,t),2.22(3H,s),4.41(2H,q),7.13-7.37(4H,m),7.51(1H,dd),7.97(1H,s),8.14(1H,dd),8.68(1H,d),9.07(1H,d),10.75(1H,s)
[实施例8]
N-(2-甲氧基乙酰基)-1-(吡啶-3-基)-4-(2-甲基苯基)-1H-吡唑-3-羧酰胺(本发明化合物编号:A-4808)的制造
使1-(吡啶-3-基)-4-(2-甲基苯基)-1H-吡唑-3-羧酰胺(本发明化合物编号:A-0020;0.20g、0.72mmol)溶解于甲苯(5mL)中,添加2-甲氧基乙酰氯(0.17g、1.6mmol)并进行加热回流2小时。将反应溶液注入水中,并以乙酸乙酯进行萃取。用无水硫酸镁使所得到的有机层干燥后,减压蒸馏除去溶剂。通过硅胶柱色谱法对残留物进行纯化,得到N-(2-甲氧基乙酰基)-1-(吡啶-3-基)-4-(2-甲基苯基)-1H-吡唑-3-羧酰胺(0.080g、产率:32%)。
1H-NMR数据(300MHz,CDCl3/TMSδ(ppm)):2.24(3H,s),3.50(3H,s),4.42(2H,s),7.23-7.37(4H,m),7.52(1H,dd),8.00(1H,s),8.14(1H,dd),8.69(1H,d),9.06(1H,d),9.89(1H,s)
[实施例9]
1-(吡啶-3-基)-4-(2-甲基苯基)-1H-吡唑-3-硫代酰胺(carbothioamide)(本发明化合物编号:A-8646)的制造
使1-(吡啶-3-基)-4-(2-甲基苯基)-1H-吡唑-3-羧酰胺(本发明化合物编号:A-0020;0.70g、2.5mmol)溶解于1,4-二噁烷(10mL)中,添加Lawesson试剂(1.2g、3.0mmol),并在80℃下搅拌40分钟。反应结束后,减压蒸馏除去溶剂,通过硅胶柱色谱法对残留物进行纯化,得到1-(吡啶-3-基)-4-(2-甲基苯基)-1H-吡唑-3-硫代酰胺(0.66g、产率:89%)。
1H-NMR数据(400MHz,CDCl3/TMSδ(ppm)):2.24(3H,s),7.22-7.38(5H,m),7.47(1H,dd),7.90(1H,s),8.00(1H,s),8.12(1H,dd),8.64(1H,d),9.06(1H,d)
将根据上述实施例所合成的本发明化合物[I]的物理性质,包括上述实施例中的值,显示于下表320至表329中,同样地将本发明化合物[II]的物理性质显示于下表330至表340中。此外,表中的化合物编号及记号如上述定义。
[表320]
[表321]
[表322]
[表323]
[表324]
[表325]
[表326]
[表327]
[表328]
[表329]
[表330]
[表331]
[表332]
[表333]
[表334]
[表335]
[表336]
[表337]
[表338]
[表339]
[表340]
接着,具体说明使用以上述方式所制造的本发明的吡唑衍生物或其农业上可接受的盐的本发明的有害生物防治剂的制剂例。应注意的是,化合物、添加剂的种类以及混合比并不仅限于此,而可广范围地进行变更。此外,在以下的说明中,“份”表示质量份。
[制剂例1]乳剂
将以上成分均匀地溶解而形成乳剂。
[制剂例2]水合剂
将以上成分均匀地混合粉碎而形成水合剂。
[制剂例3]粉剂
表1至表334所记载的化合物 2份
硅藻土 5份
黏土 93份
将以上成分均匀地混合粉碎而形成粉剂。
[制剂例4]粒剂
将以上成分均匀地混合粉碎。向该混合物中添加相当于20份的水并进行捏合,用挤压造粒机加工成14至32目的粒状,然后干燥得到粒剂。
[制剂例5]悬浮剂
用高速搅拌机将以上成分混合30分钟后,用湿式粉碎机进行粉碎而形成悬浮剂。
[制剂例6]颗粒水合剂
将这些成分混合、捏合并挤出成粒。用流化床干燥机干燥得到的颗粒,得到颗粒水合剂。
接着,用试验例说明本发明的有害生物防治剂所发挥的效果。
[试验例1]小菜蛾杀虫试验
将根据制剂例2所制备的水合剂用水稀释,以使活性成分的浓度为500ppm。将卷心菜叶浸渍于该液剂中,风干后,放入塑料杯。向其中放入10只小菜蛾2龄幼虫并用盖子盖住杯子。然后,将杯子置于25℃的恒温室,6天后检查死虫数,通过数学式1的计算式求出死虫率。试验采用“无重复试验”(1連制)。
[数学式1]
根据该试验而呈现50%以上的死虫率的化合物显示如下。
A-0020、A-0023、A-0025、A-0029、A-0047、A-0059、A-0125、A-0134、A-0144、A-0147、A-0148、A-0152、A-0176、A-0182、A-0183、A-0185、A-0186、A-0192、A-0227、A-0260、A-0263、A-0266、A-0269、A-0329、A-0338、A-0340、A-0524、A-0542、A-0551、A-0555、A-0557、A-0571、A-0573、A-0574、A-0577、A-0578、A-0587、A-0588、A-0593、A-0594、A-0597、A-0598、A-0600、A-0613、A-0614、A-0618、A-0624、A-0634、A-0636、A-0637、A-0638、A-0639、A-0645、A-0649、A-0654、A-0655、A-0659、A-0663、A-0670、A-0671、A-0688、A-0692、A-0693、A-0697、A-0701、A-0709、A-0875、A-0906、A-0907、A-0908、A-0909、A-0911、A-1067、A-1077、A-1097、A-1117、A-1136、A-1141、A-1145、A-1151、A-1155、A-1156、A-1162、A-1164、A-1980、A-2182、A-2384、A-2600、A-2990、A-3192、A-3812、A-4404、A-4606、A-5414、A-7030、A-7838、A-8646、A-9993、A-9994、B-0003、B-0018、B-0027、B-0090、B-0095、B-0099、B-0100、B-0107、B-0165、B-0199、B-0205、B-0290、B-0296、B-0367、B-0456、B-0457、B-0458、B-0471、C-0001、C-0002、C-0008、C-0020、C-0021、C-0023、C-0047、C-0086、C-0134、C-0137、C-0144、C-0145、C-0152、C-0176、C-0179、C-0185、C-0186、C-0189、C-0198、C-0239、C-0263、C-0269、C-0329、C-0340、C-0520、C-0555、C-0557、C-0561、C-0563、C-0571、C-0573、C-0587、C-0588、C-0594、C-0597、C-0598、C-0600、C-0614、C-0624、C-0629、C-0634、C-0637、C-0638、C-0656、C-0663、C-0907、C-0910、C-1067、C-1097、C-1145、C-1153、C-1162、C-1165、D-0035、D-0098、D-0099、D-0103、D-0107、D-0108、D-0207、D-0309、D-0466、E-0002、E-0003、E-0006、E-0008、E-0020、E-0023、E-0041、E-0047、E-0086、E-0119、E-0125、E-0128、E-0134、E-0137、E-0176、E-0177、E-0179、E-0263、E-0329、E-0340、E-0518、E-0557、E-0561、E-0563、E-0571、E-0573、E-0587、E-0588、E-0593、E-0594、E-0597、E-0598、E-0600、E-0609、E-0613、E-0614、E-0618、E-0624、E-0633、E-0644、E-0652、E-0653、E-0663、E-0693、E-0733、E-0907、E-0908、E-1067、E-1076、E-1077、E-1117、E-1148、E-1152、F-0012、F-0108、F-0207、F-0295、F-0301、F-0309、F-0464、F-0466
[试验例2]棉铃虫杀虫试验
将根据制剂例2所制备的水合剂用水稀释,以使活性成分的浓度为500ppm。将卷心菜叶浸渍于该液剂中,风干后,放入塑料杯。将五个刚孵化的棉铃虫幼虫放入杯中,并用盖子盖住杯子。然后,将杯子置于25℃的恒温室,6天后检查死虫数,通过数学式1的计算式求出死虫率。试验采用“双重复试验”(2連制)。
根据该试验而呈现50%以上的死虫率的化合物显示如下。A-0002、A-0008、A-0014、A-0020、A-0023、A-0029、A-0086、A-0103、A-0128、A-0137、A-0145、A-0148、A-0152、A-0179、A-0183、A-0188、A-0242、A-0263、A-0266、A-0329、A-0338、A-0340、A-0512、A-0524、A-0542、A-0551、A-0553、A-0555、A-0561、A-0574、A-0583、A-0587、A-0588、A-0591、A-0593、A-0594、A-0597、A-0608、A-0614、A-0633、A-0634、A-0638、A-0639、A-0644、A-0645、A-0653、A-0654、A-0655、A-0659、A-0660、A-0671、A-0688、A-0689、A-0691、A-0692、A-0693、A-0705、A-0709、A-0713、A-0906、A-0907、A-0908、A-0909、A-0910、A-0911、A-0912、A-0913、A-1076、A-1117、A-1140、A-1141、A-1145、A-1146、A-1148、A-1151、A-1153、A-1158、A-1162、A-1163、A-1164、A-1165、A-1166、A-2182、A-2384、A-2586、A-2600、A-2990、A-6020、A-7838、A-9480、A-9993、A-9994、A-10000、B-0004、B-0027、B-0090、B-0091、B-0095、B-0099、B-0100、B-0165、B-0199、B-0287、B-0290、B-0367、B-0454、B-0455、B-0457、B-0471、C-0004、C-0008、C-0021、C-0022、C-0041、C-0046、C-0086、C-0120、C-0125、C-0134、C-0137、C-0147、C-0179、C-0189、C-0227、C-0239、C-0263、C-0266、C-0269、C-0320、C-0329、C-0340、C-0512、C-0518、C-0553、C-0557、C-0561、C-0563、C-0573、C-0574、C-0577、C-0578、C-0587、C-0588、C-0594、C-0597、C-0598、C-0600、C-0608、C-0614、C-0633、C-0636、C-0637、C-0653、C-0656、C-0659、C-0660、C-0689、C-0692、C-0705、C-0906、C-0907、C-0908、C-0911、C-1117、C-1140、C-1141、C-1160、C-1162、C-1163、C-1165、D-0003、D-0004、D-0012、D-0035、D-0099、D-0107、D-0108、D-0115、D-0207、D-0295、D-0301、D-0375、D-0464、D-0469、E-0006、E-0008、E-0047、E-0086、E-0119、E-0121、E-0128、E-0148、E-0177、E-0263、E-0329、E-0521、E-0542、E-0561、E-0563、E-0571、E-0573、E-0587、E-0588、E-0594、E-0597、E-0600、E-0614、E-0633、E-0639、E-0644、E-0659、E-0660、E-0688、E-0692、E-0693、E-0705、E-0733、E-0906、E-0907、E-0908、E-0911、E-0912、E-1076、E-1117、E-1160、F-0003、F-0012、F-0017、F-0099、F-0108、F-0207、F-0301、F-0375、F-0461、F-0466
[试验例3]棉蚜杀虫试验
将根据制剂例2所制备的水合剂用水稀释,以使活性成分的浓度为500ppm。将预先接种棉蚜幼虫的黄瓜苗浸渍于该液剂中并使其风干。将处理后的黄瓜苗置于25℃的恒温室,3天后计算生存虫数,通过数学式1的计算式求出死虫率。试验采用“无重复试验”。
根据该试验而呈现50%以上的死虫率的化合物显示如下。A-0001、A-0002、A-0004、A-0005、A-0006、A-0007、A-0008、A-0014、A-0020、A-0021、A-0022、A-0023、A-0025、A-0029、A-0044、A-0045、A-0046、A-0047、A-0059、A-0086、A-0101、A-0103、A-0119、A-0120、A-0121、A-0122、A-0123、A-0124、A-0143、A-0144、A-0145、A-0146、A-0147、A-0148、A-0152、A-0176、A-0177、A-0179、A-0182、A-0183、A-0185、A-0186、A-0189、A-0260、A-0263、A-0266、A-0269、A-0320、A-0340、A-0347、A-0512、A-0524、A-0550、A-0555、A-0557、A-0561、A-0563、A-0571、A-0573、A-0574、A-0577、A-0578、A-0582、A-0583、A-0591、A-0593、A-0594、A-0597、A-0598、A-0603、A-0609、A-0613、A-0614、A-0618、A-0634、A-0636、A-0637、A-0639、A-0644、A-0652、A-0653、A-0654、A-0655、A-0656、A-0659、A-0660、A-0663、A-0665、A-0670、A-0688、A-0689、A-0691、A-0692、A-0693、A-0697、A-0701、A-0705、A-0709、A-0712、A-0713、A-0875、A-0906、A-0907、A-0908、A-0909、A-0913、A-1067、A-1077、A-1102、A-1117、A-1134、A-1140、A-1141、A-1145、A-1146、A-1147、A-1152、A-1157、A-1158、A-1160、A-1161、A-1162、A-1163、A-1165、A-1166、A-2182、A-2586、A-2600、A-3596、A-3798、A-3812、A-4202、A-4404、A-4606、A-4808、A-5414、A-5616、A-6020、A-6022、A-7434、A-7636、A-7838、A-8040、A-8862、A-9993、A-9994、B-0001、B-0002、B-0003、B-0004、B-0009、B-0027、B-0091、B-0095、B-0099、B-0107、B-0290、B-0293、B-0301、B-0367、B-0389、B-0453、B-0455、C-0001、C-0002、C-0003、C-0006、C-0007、C-0020、C-0021、C-0025、C-0044、C-0045、C-0047、C-0119、C-0122、C-0125、C-0128、C-0134、C-0137、C-0145、C-0176、C-0177、C-0183、C-0186、C-0189、C-0227、C-0239、C-0320、C-0553、C-0557、C-0561、C-0574、C-0578、C-0594、C-0600、C-0637、C-0638、C-0639、C-0653、C-0655、C-0660、C-0697、C-0907、C-0910、C-0911、C-1077、C-1117、C-1141、C-1162、D-0002、D-0003、D-0005、D-0008、D-0012、D-0035、D-0103、D-0107、D-0108、D-0115、D-0207、D-0213、D-0301、D-0375、D-0463、D-0464、D-0469、E-0023、E-0121、E-0124、E-0128、E-0269、E-0609、E-0656、E-0693、E-1067、F-0003
[试验例4]褐飞虱杀虫活性试验
将根据制剂例2所制备的水合剂用水稀释,以使活性成分的浓度为500ppm。将米糠浸渍于该液剂中,放入塑料杯。向该塑料杯中放入10只褐飞虱2龄幼虫,封盖并置于25℃的恒温室。6天后计算生存虫数,通过数学式1的计算式求出死虫率。试验采用“无重复试验”。
根据该试验而呈现50%以上的死虫率的化合物显示如下。A-0002、A-0003、A-0004、A-0005、A-0007、A-0008、A-0014、A-0020、A-0021、A-0022、A-0023、A-0025、A-0041、A-0045、A-0046、A-0047、A-0059、A-0086、A-0101、A-0119、A-0120、A-0121、A-0122、A-0123、A-0124、A-0125、A-0128、A-0134、A-0145、A-0146、A-0147、A-0148、A-0152、A-0176、A-0177、A-0179、A-0182、A-0183、A-0185、A-0186、A-0188、A-0189、A-0198、A-0227、A-0239、A-0242、A-0260、A-0263、A-02666、A-0269、A-0320、A-0329、A-0340、A-0347、A-0548、A-0550、A-0551、A-0555、A-0557、A-0561、A-0563、A-0571、A-0577、A-0578、A-0583、A-0587、A-0588、A-0591、A-0593、A-0594、A-0597、A-0598、A-0600、A-0603、A-0609、A-0613、A-0614、A-0618、A-0624、A-0629、A-0633、A-0634、A-0636、A-0637、A-0638、A-0639、A-0644、A-0645、A-0653、A-0654、A-0655、A-0656、A-0659、A-0660、A-0663、A-0664、A-0665、A-0670、A-0671、A-0688、A-0689、A-0692、A-0693、A-0697、A-0701、A-0705、A-0709、A-0712、A-0713、A-0733、A-0907、A-0910、A-1067、A-1076、A-1077、A-1097、A-1102、A-1117、A-1134、A-1136、A-1140、A-1145、A-1146、A-1147、A-1148、A-1151、A-1153、A-1154、A-1155、A-1156、A-1158、A-1159、A-1161、A-1162、A-1163、A-1164、A-1166、A-1980、A-2182、A-2384、A-2586、A-2600、A-2788、A-2990、A-3192、A-3596、A-3798、A-3812、A-4000、A-4202、A-4404、A-4808、A-5414、A-5616、A-6020、A-6222、A-6424、A-7030、A-7232、A-7434、A-7636、A-7838、A-8040、A-8242、A-8444、A-8646、A-8730、A-8862、A-9435、A-9993、A-9994、A-10001、B-0001、B-0004、B-0018、B-0027、B-0090、B-0091、B-0095、B-0099、B-0100、B-0107、B-0165、B-0205、B-0287、B-0290、B-0296、B-0301、B-0389、B-0454、B-0455、B-0456、B-0457、B-0458、B-0459、B-0460、C-0001、C-0002、C-0021、C-0022、C-0023、C-0025、C-0041、C-0044、C-0047、C-0086、C-0119、C-0120、C-0121、C-0123、C-0124、C-0125、C-0128、C-0134、
Claims (13)
1.一种由通式[I]表示的吡唑衍生物或其农业学上可接受的盐,
[化学式1]
式中,
p表示0或1的整数,
R1、R2、R3、R4和R5分别独立地表示氢原子、卤素原子、C1–C6烷基、羟基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基、C3–C6环烷基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、氰基或硝基,
A表示氧原子或硫原子,
Q表示卤素原子、未取代的或经(R8)m取代的C6–C10芳基或未取代的或经(R8)m取代的杂芳基,
R6和R7分别独立地表示氢原子、C1–C6烷基、C3–C6环烷基、C3–C6环烷基C1–C6烷基、C2–C7炔基、C2–C6烯基、羟基、C1–C6烷氧基、C1–C6烷氧基C1–C6烷基、C1–C6卤代烷基、2-四氢呋喃基、3-四氢呋喃基、2-四氢吡喃基、4-四氢吡喃基、氰基C1–C6烷基、氰基C3–C6环烷基、羟基C1–C6烷基、甲酰基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、C1–C6烷基羰基、C1–C6烷氧基C1–C6烷基羰基、C3–C6环烷基羰基、C3–C6环烷基C1–C6烷基羰基、C1–C6烷氧基羰基、氨甲酰基、单(C1–C6烷基)氨基羰基、二(C1–C6烷基)氨基羰基、未取代的或经(R9)n取代的苯基羰基、未取代的或经(R9)n取代的C7–C13芳烷基羰基、未取代的或经(R9)n取代的吡啶基羰基、未取代的或经(R9)n取代的吡唑基羰基、吡啶-2-基甲基、吡啶-3-基甲基、(C1–C6烷基)硫代羰基、(C1–C6烷氧基)硫代羰基、硫代氨甲酰基、单(C1–C6烷基)氨基硫代羰基、二(C1–C6烷基)氨基硫代羰基、C1–C6烷基磺酰基、氨磺酰基、单(C1–C6烷基)氨基磺酰基、二(C1–C6烷基)氨基磺酰基、R10R11N-C1–C6烷基、C1–C6烷氧基羰基C1–C6烷基、氨基羰基C1–C6烷基、单(C1–C6烷基)氨基羰基C1–C6烷基、单(C3–C6环烷基)氨基羰基C1–C6烷基、单(C1–C6卤代烷基)氨基羰基C1–C6烷基、二(C1–C6烷基)氨基羰基C1–C6烷基、肟基、C1–C6烷氧基亚氨基、肟基C1–C6烷基、或C1–C6烷氧基亚氨基C1–C6烷基,R6和R7可以一起形成=CR12N(R13)R14或=CR12OR15,此外,R6和R7可以与它们所键合的碳原子一起形成3至6元碳环、或具有1至4个选自氧原子、硫原子和氮原子的杂原子的3至6元杂环,该杂环可由卤素原子、氰基、硝基、C1–C6烷基、C1–C6烷氧基、C1–C6卤代烷基或氧代基团所取代,
R8表示氢原子、卤素原子、羟基、硫醇基、C1–C6烷基、C1–C6卤代烷基、C3–C6环烷基、C3–C6环烷基C1–C6烷基、C3–C6环烷基C2–C6炔基、C3–C6卤代环烷基、C3–C6卤代环烷基C1–C6烷基、C2–C6烯基、C2–C6卤代烯基、C2–C7炔基、C2–C6卤代炔基、C1–C6烷氧基、C1–C6卤代烷氧基、C3–C6环烷氧基、环氧乙烷-2-基、单(环氧乙烷-2-基)C1–C3烷基、C3–C6卤代环烷氧基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、C3–C6环烷基硫基、C3–C6环烷基亚磺酰基、C3–C6环烷基磺酰基、C1–C6卤代烷基硫基、C1–C6卤代烷基亚磺酰基、C1–C6卤代烷基磺酰基、甲酰基、C1–C6烷基羰基、C1–C6卤代烷基羰基、C1–C6烷氧基羰基、氨基羰基、单(C1–C6烷基)氨基羰基、二(C1–C6烷基)氨基羰基、氨基C1–C6烷基、单(C1–C6烷基)氨基C1–C6烷基、二(C1–C6烷基)氨基C1–C6烷基、三(C1–C6烷基)甲硅烷基氧基C1–C6烷基、C1–C6烷基羰基C1–C6烷基、C1–C6烷基羰基氧基C1–C6烷基、C1–C6卤代烷基羰基C1–C6烷基、C1–C6烷氧基羰基C1–C6烷基、羟基C1–C6烷基、C1–C6烷氧基C1–C6烷基、C1–C6卤代烷氧基C1–C6烷基、C1–C6烷氧基C1–C6卤代烷基、C1–C6卤代烷氧基C1–C6卤代烷基、甲酰氧基、C1–C6烷基羰基氧基、C1–C6卤代烷基羰基氧基、氨基羰基氧基、单(C1–C6烷基)氨基羰基氧基、二(C1–C6烷基)氨基羰基氧基、氨基羰基氧基C1–C6烷基、单(C1–C6烷基)氨基羰基氧基C1–C6烷基、二(C1–C6烷基)氨基羰基氧基C1–C6烷基、C1–C6烷氧基羰基氧基、C1–C6烷氧基羰基氧基C1–C6烷基、C1–C6烷基磺酰基氧基、C1–C6卤代烷基磺酰基氧基、C1–C6烷硫基C1–C6烷基、C1–C6烷基亚磺酰基C1–C6烷基、C1–C6烷基磺酰基C1–C6烷基、C1–C6卤代烷硫基C1–C6烷基、C1–C6卤代烷基亚磺酰基C1–C6烷基、C1–C6卤代烷基磺酰基C1–C6烷基、C3–C6环烷基C1–C6烷氧基、C3–C6卤代环烷基C1–C6烷氧基、C3–C6环烷基C1–C6烷硫基、C3–C6环烷基C1–C6烷基亚磺酰基、C3–C6环烷基C1–C6烷基磺酰基、C3–C6卤代环烷基C1–C6烷硫基、C3–C6卤代环烷基C1–C6烷基亚磺酰基、C3–C6卤代环烷基C1–C6烷基磺酰基、未取代的或经(R9)n取代的苯基、未取代的或经(R9)n取代的吡唑-1-基、未取代的或经(R9)n取代的吡啶-2-基、未取代的或经(R9)n取代的嘧啶-2-基、未取代的或经(R9)n取代的吡嗪-2-基、未取代的或经(R9)n取代的1,3,5-三嗪-2-基、未取代的或经(R9)n取代的1,2,4-三嗪-3-基、未取代的或经(R9)n取代的1,2,4三嗪-5-基、未取代的或经(R9)n取代的1,2,4-三嗪-6-基、未取代的或经(R9)n取代的苯氧基、未取代的或经(R9)n取代的苄基、未取代的或经(R9)n取代的苄氧基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、羧基、1,3-二氧戊环-2-基、1,3-二烷-2-基、未取代的或经(R9)n取代的1H-咪唑-2-基、未取代的或经(R9)n取代的噻唑-2-基、未取代的或经(R9)n取代的唑-2-基、(肟基)甲基、(甲基氧基亚氨基)甲基、未取代的或经(R9)n取代的异唑-3-基、未取代的或经(R9)n取代的4,5-二氢-3-异唑基、氰基或硝基,并且进一步地,相邻的两个R8可以与各R8所键合的碳原子一起形成4至8元碳环或具有1至4个选自氧原子、硫原子及氮原子的杂原子的4至8元杂环,此时所形成的碳环或杂环可由选自卤素原子、氰基、硝基、C1–C6烷基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基或氧代基团中的一个或多个化学上可接受的取代基所取代,
R9表示卤素原子、C1–C6烷基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、C1–C6卤代烷基硫基、C1–C6卤代烷基亚磺酰基、C1–C6卤代烷基磺酰基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、氰基或硝基,
R10和R11分别独立地表示氢原子、C1–C6烷基、C1–C6卤代烷基或C3–C6环烷基,并且进一步地,R10和R11可以与它们所键合的碳原子一起形成3至6元环,
R12表示氢原子、C1–C6烷基或C3–C6环烷基,
R13和R14分别独立地表示氢原子、C1–C6烷基、C1–C6卤代烷基、C3–C6环烷基或C1–C6烷氧基,并且进一步地,R13和R14可以与它们所键合的碳原子一起形成3至6元碳环、或具有1至4个选自氧原子、硫原子和氮原子的杂原子的3至6元杂环,
R15表示C1–C6烷基,
m表示化学上可接受的R8的数目,并且为0到7的整数,当m为2以上时,R8可以彼此相同或不同,
n表示化学上可接受的R9的数目,并且是0至5的整数,并且当n为2以上时,R9可以彼此相同或不同。
2.一种由通式[II]表示的吡唑衍生物或其农业学上可接受的盐,
[化学式2]
式中,
p表示0或1的整数,
R1、R2、R3、R4和R5分别独立地表示氢原子、卤素原子、C1–C6烷基、羟基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基、C3–C6环烷基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、氰基或硝基,
R16表示氢原子或C1–C6烷基,
Q'表示卤素原子、C1–C6烷基磺酰基氧基、C1–C6卤代烷基磺酰基氧基、二(C1–C6烷基)氨磺酰氧基、未取代的或经(R9)n取代的苯基磺酰基氧基、未取代的或经(R8)m取代的C6–C10芳基、或未取代的或经(R8)m取代的杂芳基,
R8表示氢原子、卤素原子、羟基、硫醇基、C1–C6烷基、C1–C6卤代烷基、C3–C6环烷基、C3–C6环烷基C1–C6烷基、C3–C6环烷基C2–C6炔基、C3–C6卤代环烷基、C3–C6卤代环烷基C1–C6烷基、C2–C6烯基、C2–C6卤代烯基、C2–C7炔基、C2–C6卤代炔基、C1–C6烷氧基、C1–C6卤代烷氧基、C3–C6环烷氧基、环氧乙烷-2-基、单(环氧乙烷-2-基)C1–C3烷基、C3–C6卤代环烷氧基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、C3–C6环烷硫基、C3–C6环烷基亚磺酰基、C3–C6环烷基磺酰基、C1–C6卤代烷硫基、C1–C6卤代烷基亚磺酰基、C1–C6卤代烷基磺酰基、甲酰基、C1–C6烷基羰基、C1–C6卤代烷基羰基、C1–C6烷氧基羰基、氨基羰基、单(C1–C6烷基)氨基羰基、二(C1–C6烷基)氨基羰基、氨基C1–C6烷基、单(C1–C6烷基)氨基C1–C6烷基、二(C1–C6烷基)氨基C1–C6烷基、三(C1–C6烷基)甲硅烷基氧基C1–C6烷基、C1–C6烷基羰基C1–C6烷基、C1–C6烷基羰基氧基C1–C6烷基、C1–C6卤代烷基羰基C1–C6烷基、C1–C6烷氧基羰基C1–C6烷基、羟基C1–C6烷基、C1–C6烷氧基C1–C6烷基、C1–C6卤代烷氧基C1–C6烷基、C1–C6烷氧基C1–C6卤代烷基、C1–C6卤代烷氧基C1–C6卤代烷基、甲酰氧基、C1–C6烷基羰基氧基、C1–C6卤代烷基羰基氧基、氨基羰基氧基、单(C1–C6烷基)氨基羰基氧基、二(C1–C6烷基)氨基羰基氧基、氨基羰基氧基C1–C6烷基、单(C1–C6烷基)氨基羰基氧基C1–C6烷基、二(C1–C6烷基)氨基羰基氧基C1–C6烷基、C1–C6烷氧基羰基氧基、C1–C6烷氧基羰基氧基C1–C6烷基、C1–C6烷基磺酰基氧基、C1–C6卤代烷基磺酰基氧基、C1–C6烷硫基C1–C6烷基、C1–C6烷基亚磺酰基C1–C6烷基、C1–C6烷基磺酰基C1–C6烷基、C1–C6卤代烷硫基C1–C6烷基、C1–C6卤代烷基亚磺酰基C1–C6烷基、C1–C6卤代烷基磺酰基C1–C6烷基、C3–C6环烷基C1–C6烷氧基、C3–C6卤代环烷基C1–C6烷氧基、C3–C6环烷基C1–C6烷硫基、C3–C6环烷基C1–C6烷基亚磺酰基、C3–C6环烷基C1–C6烷基磺酰基、C3–C6卤代环烷基C1–C6烷硫基、C3–C6卤代环烷基C1–C6烷基亚磺酰基、C3–C6卤代环烷基C1–C6烷基磺酰基、未取代的或经(R9)n取代的苯基、未取代的或经(R9)n取代的吡唑-1-基、未取代的或经(R9)n取代的吡啶-2-基、未取代的或经(R9)n取代的嘧啶-2-基、未取代的或经(R9)n取代的吡嗪-2-基、未取代的或经(R9)n取代的1,3,5-三嗪-2-基、未取代的或经(R9)n取代的1,2,4-三嗪-3-基、未取代的或经(R9)n取代的1,2,4三嗪-5-基、未取代的或经(R9)n取代的1,2,4-三嗪-6-基、未取代的或经(R9)n取代的苯氧基、未取代的或经(R9)n取代的苄基、未取代的或经(R9)n取代的苄氧基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、羧基、1,3-二氧戊环-2-基、1,3-二烷-2-基、未取代的或经(R9)n取代的1H-咪唑-2-基、未取代的或经(R9)n取代的噻唑-2-基、未取代的或经(R9)n取代的唑-2-基、(肟基)甲基、(甲基氧基亚氨基)甲基、未取代的或经(R9)n取代的异唑-3-基、未取代的或经(R9)n取代的4,5-二氢-3-异唑基、氰基或硝基,并且进一步地,相邻的两个R8可以与各R8所键合的碳原子一起形成4至8元碳环或具有1至4个选自氧原子、硫原子及氮原子的杂原子的4至8元杂环,此时所形成的碳环或杂环可由选自卤素原子、氰基、硝基、C1–C6烷基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基或氧代基团中的一个或多个化学上可接受的取代基所取代,
R9表示卤素原子、C1–C6烷基、C1–C6卤代烷基、C1–C6烷氧基、C1–C6卤代烷氧基、C1–C6烷硫基、C1–C6烷基亚磺酰基、C1–C6烷基磺酰基、C1–C6卤代烷硫基、C1–C6卤代烷基亚磺酰基、C1–C6卤代烷基磺酰基、氨基、单(C1–C6烷基)氨基、二(C1–C6烷基)氨基、氰基或硝基,
m表示化学上可接受的R8的数目,并且为0到7的整数,当m为2以上时,R8可以彼此相同或不同,
n表示化学上可接受的R9的数目,并且是0至5的整数,并且当n为2以上时,R9可以彼此相同或不同。
3.一种农药组合物,其包含根据权利要求1或2所述的吡唑衍生物或其农业上可接受的盐作为活性成分。
4.根据权利要求3所述的农药组合物,其中,该农药组合物进一步包含表面活性剂。
5.一种有害生物防治剂,其包含根据权利要求1或2所的吡唑衍生物或其农业上可接受的盐作为活性成分。
6.根据权利要求5所述的有害生物防治剂,其为杀虫剂。
7.根据权利要求5所述的有害生物防治剂,其对栽培农艺或园艺用植物的旱地或水田中的有害生物具有防治效力。
8.根据权利要求7所述的有害生物防治剂,其中,所述农艺或园艺用植物为利用育种法或基因重组技术而被赋予了耐性的植物。
9.一种有害生物的防治方法,其中使用有效成分量的根据权利要求1或2所述的吡唑衍生物或其农业上可接受的盐。
10.一种有害生物的防治方法,其中,将包含根据权利要求1或2所述的吡唑衍生物或其农业上可接受的盐作为活性成分的农药组合物同时或分批地作用于农艺或园艺用作物或将要培育或正在培育农艺或园艺用作物的场所。
11.根据权利要求9或10所述的有害生物的防治方法,其中,施用有害生物防治剂的场所为水田、旱地、草地、果树园、非农耕地、温室、育苗设施或植物工厂。
12.根据权利要求9至11中任一项所述的有害生物的防治方法,其中将吡唑衍生物或其农业上可接受的盐用作杀虫剂。
13.一种有害生物防治剂的使用方法,其中,将根据权利要求5至8中任一项所述的有害生物防治剂用于防治对农艺或园艺用作物有害的生物。
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JPH11199566A (ja) * | 1997-04-03 | 1999-07-27 | Mitsubishi Chemical Corp | 1−置換−ピラゾール−3−カルボキサミド誘導体およびこれを有効成分とする殺菌剤 |
WO2012102387A1 (ja) * | 2011-01-27 | 2012-08-02 | 日産化学工業株式会社 | ピラゾール誘導体及び有害生物防除剤 |
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JPH0812654A (ja) * | 1994-06-27 | 1996-01-16 | Sankyo Co Ltd | 4−ハロピラゾール−3−カルボン酸誘導体 |
PT1599463E (pt) | 2003-01-28 | 2013-09-03 | Du Pont | Insecticidas à base de ciano-antranilamida |
NZ573758A (en) * | 2006-07-05 | 2012-01-12 | Aventis Agriculture | 1-Phenyl-3-cyano-pyrazole derivatives and pesticidal formulations containing them |
EP1938686A1 (de) | 2006-12-29 | 2008-07-02 | Bayer CropScience AG | Substituierte 1-(3-Pyridinyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
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BR112013020282A2 (pt) * | 2011-02-09 | 2017-07-18 | Nissan Chemical Ind Ltd | derivado pirazol e agente de controle |
JP2013082699A (ja) * | 2011-09-30 | 2013-05-09 | Nissan Chem Ind Ltd | ピラゾール誘導体および有害生物防除剤 |
JP2014015447A (ja) | 2011-12-22 | 2014-01-30 | Nissan Chem Ind Ltd | ピラゾール誘導体および有害生物防除剤 |
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JPH11199566A (ja) * | 1997-04-03 | 1999-07-27 | Mitsubishi Chemical Corp | 1−置換−ピラゾール−3−カルボキサミド誘導体およびこれを有効成分とする殺菌剤 |
WO2012102387A1 (ja) * | 2011-01-27 | 2012-08-02 | 日産化学工業株式会社 | ピラゾール誘導体及び有害生物防除剤 |
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TWI816798B (zh) | 2023-10-01 |
JP7305632B2 (ja) | 2023-07-10 |
AU2019278527A1 (en) | 2020-11-19 |
JPWO2019230590A1 (ja) | 2021-07-08 |
BR112020020105B1 (pt) | 2024-04-30 |
US11964957B2 (en) | 2024-04-23 |
KR102633747B1 (ko) | 2024-02-05 |
EP3808738A4 (en) | 2022-01-19 |
CN112236421B (zh) | 2023-12-26 |
IL278957A (en) | 2021-01-31 |
CA3100410A1 (en) | 2019-12-05 |
IL278957B1 (en) | 2024-03-01 |
BR112020020105A2 (pt) | 2021-01-26 |
MX2020012792A (es) | 2021-02-26 |
AU2019278527B2 (en) | 2023-10-26 |
CA3100410C (en) | 2024-03-12 |
KR20210014653A (ko) | 2021-02-09 |
EP3808738A1 (en) | 2021-04-21 |
EP3808738B1 (en) | 2024-04-17 |
WO2019230590A1 (ja) | 2019-12-05 |
PH12020551942A1 (en) | 2021-08-16 |
IL278957B2 (en) | 2024-07-01 |
AU2019278527C1 (en) | 2024-05-30 |
TW202003488A (zh) | 2020-01-16 |
US20210261521A1 (en) | 2021-08-26 |
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