CN112226335A - 一种益生菌生产制备方法 - Google Patents
一种益生菌生产制备方法 Download PDFInfo
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- CN112226335A CN112226335A CN202011139742.4A CN202011139742A CN112226335A CN 112226335 A CN112226335 A CN 112226335A CN 202011139742 A CN202011139742 A CN 202011139742A CN 112226335 A CN112226335 A CN 112226335A
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 58
- 239000006041 probiotic Substances 0.000 title claims abstract description 43
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 62
- 238000000855 fermentation Methods 0.000 claims abstract description 30
- 230000004151 fermentation Effects 0.000 claims abstract description 30
- 238000005192 partition Methods 0.000 claims abstract description 23
- 239000001963 growth medium Substances 0.000 claims abstract description 22
- 238000003756 stirring Methods 0.000 claims abstract description 22
- 238000010438 heat treatment Methods 0.000 claims abstract description 17
- 238000007599 discharging Methods 0.000 claims abstract description 15
- 230000002572 peristaltic effect Effects 0.000 claims abstract description 8
- 238000009413 insulation Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 41
- 239000011521 glass Substances 0.000 claims description 38
- 230000000529 probiotic effect Effects 0.000 claims description 16
- 229920001971 elastomer Polymers 0.000 claims description 10
- 230000007797 corrosion Effects 0.000 claims description 7
- 238000005260 corrosion Methods 0.000 claims description 7
- 238000011081 inoculation Methods 0.000 claims description 7
- 238000007790 scraping Methods 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 11
- 230000008569 process Effects 0.000 abstract description 8
- 239000002699 waste material Substances 0.000 abstract description 5
- 239000011259 mixed solution Substances 0.000 abstract description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 8
- 235000017491 Bambusa tulda Nutrition 0.000 description 8
- 241001330002 Bambuseae Species 0.000 description 8
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 8
- 239000011425 bamboo Substances 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229920001973 fluoroelastomer Polymers 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
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- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
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- 210000004400 mucous membrane Anatomy 0.000 description 1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
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- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
- C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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Priority Applications (1)
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CN202011139742.4A CN112226335B (zh) | 2020-10-22 | 2020-10-22 | 一种益生菌生产制备方法 |
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CN202011139742.4A CN112226335B (zh) | 2020-10-22 | 2020-10-22 | 一种益生菌生产制备方法 |
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CN112226335A true CN112226335A (zh) | 2021-01-15 |
CN112226335B CN112226335B (zh) | 2021-07-20 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115011739A (zh) * | 2022-08-03 | 2022-09-06 | 南京邦康生物技术有限公司 | 一种益生菌的生产控制方法与系统 |
Citations (10)
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---|---|---|---|---|
CN204400998U (zh) * | 2015-01-09 | 2015-06-17 | 漯河市盛粮生物科技有限公司 | 一种新型的微生物发酵装置 |
CN205295350U (zh) * | 2016-01-11 | 2016-06-08 | 山东鲁抗舍里乐药业有限公司 | 一种多腔室生物好氧发酵罐 |
US20160353760A1 (en) * | 2015-06-04 | 2016-12-08 | Fairlife, Llc | Methods for Making Shelf-Stable Cultured Dairy Products |
CN107299071A (zh) * | 2017-08-16 | 2017-10-27 | 济南青瑞生物科技有限公司 | 一种肠溶益生菌制剂 |
KR20180113002A (ko) * | 2017-04-05 | 2018-10-15 | 박달수 | 한약재 추출물을 이용한 프로바이오틱 유산균 제조방법 |
CN209584186U (zh) * | 2019-02-12 | 2019-11-05 | 江苏赤山湖农业科技有限公司 | 一种便于调节发酵空间的乳酸菌发酵箱 |
CN111100819A (zh) * | 2020-01-15 | 2020-05-05 | 北京中源创能工程技术有限公司 | 芽孢杆菌和微生物菌剂及它们的应用 |
CN210887504U (zh) * | 2019-09-18 | 2020-06-30 | 安庆市索隆新材料有限公司 | 一种污水排放装置 |
CN111378563A (zh) * | 2020-04-14 | 2020-07-07 | 青岛清立源生物科技有限公司 | 一种用于益生菌培养的系统及其方法 |
CN211689085U (zh) * | 2020-01-14 | 2020-10-16 | 赵丹丹 | 一种发酵罐 |
-
2020
- 2020-10-22 CN CN202011139742.4A patent/CN112226335B/zh active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN204400998U (zh) * | 2015-01-09 | 2015-06-17 | 漯河市盛粮生物科技有限公司 | 一种新型的微生物发酵装置 |
US20160353760A1 (en) * | 2015-06-04 | 2016-12-08 | Fairlife, Llc | Methods for Making Shelf-Stable Cultured Dairy Products |
CN205295350U (zh) * | 2016-01-11 | 2016-06-08 | 山东鲁抗舍里乐药业有限公司 | 一种多腔室生物好氧发酵罐 |
KR20180113002A (ko) * | 2017-04-05 | 2018-10-15 | 박달수 | 한약재 추출물을 이용한 프로바이오틱 유산균 제조방법 |
CN107299071A (zh) * | 2017-08-16 | 2017-10-27 | 济南青瑞生物科技有限公司 | 一种肠溶益生菌制剂 |
CN209584186U (zh) * | 2019-02-12 | 2019-11-05 | 江苏赤山湖农业科技有限公司 | 一种便于调节发酵空间的乳酸菌发酵箱 |
CN210887504U (zh) * | 2019-09-18 | 2020-06-30 | 安庆市索隆新材料有限公司 | 一种污水排放装置 |
CN211689085U (zh) * | 2020-01-14 | 2020-10-16 | 赵丹丹 | 一种发酵罐 |
CN111100819A (zh) * | 2020-01-15 | 2020-05-05 | 北京中源创能工程技术有限公司 | 芽孢杆菌和微生物菌剂及它们的应用 |
CN111378563A (zh) * | 2020-04-14 | 2020-07-07 | 青岛清立源生物科技有限公司 | 一种用于益生菌培养的系统及其方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115011739A (zh) * | 2022-08-03 | 2022-09-06 | 南京邦康生物技术有限公司 | 一种益生菌的生产控制方法与系统 |
CN115011739B (zh) * | 2022-08-03 | 2022-11-01 | 南京邦康生物技术有限公司 | 一种益生菌的生产控制方法与系统 |
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Denomination of invention: A method for producing probiotics Effective date of registration: 20221014 Granted publication date: 20210720 Pledgee: Huishang Bank Co.,Ltd. Bengbu donghuai sub branch Pledgor: Anhui zhongweiyuan Biotechnology Co.,Ltd. Registration number: Y2022980018371 |
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Date of cancellation: 20231130 Granted publication date: 20210720 Pledgee: Huishang Bank Co.,Ltd. Bengbu donghuai sub branch Pledgor: Anhui zhongweiyuan Biotechnology Co.,Ltd. Registration number: Y2022980018371 |
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Denomination of invention: A method for producing probiotics Effective date of registration: 20231212 Granted publication date: 20210720 Pledgee: Huishang Bank Co.,Ltd. Bengbu donghuai sub branch Pledgor: Anhui zhongweiyuan Biotechnology Co.,Ltd. Registration number: Y2023980070962 |