CN112206272A - External cold compress gel for closed soft tissue - Google Patents

External cold compress gel for closed soft tissue Download PDF

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Publication number
CN112206272A
CN112206272A CN202011235497.7A CN202011235497A CN112206272A CN 112206272 A CN112206272 A CN 112206272A CN 202011235497 A CN202011235497 A CN 202011235497A CN 112206272 A CN112206272 A CN 112206272A
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parts
cold compress
soft tissue
gel
blood
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李田来
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

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  • Life Sciences & Earth Sciences (AREA)
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  • Diabetes (AREA)
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Abstract

The invention relates to the technical field of traditional Chinese medicine compound, in particular to an external cold compress gel for closed soft tissue, which comprises borneol, frankincense, myrrh, angelica dahurica, dragon's blood and the like; the invention takes sodium alginate and collagen as carriers, and is matched with borneol, frankincense, myrrh, angelica dahurica, dragon's blood and some natural high molecular substances, and the effective components penetrate into the skin by applying a transdermal absorption process to achieve the effect of cooling. The gel is applied to the parts of body, such as burns, scalds, incised wounds, frostbites, skin ulcers, nasal cavities, bedsores, after operations and the like in an external application mode, the effective components travel along with the channels and collaterals, and the gel is applied to wound wounds to achieve the effects of stopping bleeding and diminishing inflammation, integrates the functions of astringency and repair, quickly achieves the effects of wound inflammation and exudate adsorption and drying, repairs and heals scabs, shortens the treatment course, does not enter the digestive system in vivo, and has no any injury or toxic or side effect. The cooling substance does not contain a component that exerts a pharmacological, immunological, or metabolic effect.

Description

External cold compress gel for closed soft tissue
Technical Field
The invention relates to the technical field of traditional Chinese medicine compounds, in particular to an external cold compress gel for closed soft tissues.
Background
Closed soft tissue injury refers to the condition where the local skin or mucosa is intact and there is no breach to the environment, and bleeding from the injury accumulates in the tissue. Is one type of soft tissue injury. The muscle is strongly contracted under the action of blunt force, and the joint movement exceeds the normal range or is caused by strain and the like.
Closed soft tissue injuries are divided into acute injuries and chronic injuries. Within 24 or 48 hours after the early injury of acute injury, the symptoms are mainly red, swelling, heat, pain and dysfunction, and the inflammatory reaction is serious; the treatment principle is as follows: hemostasis, pain relief, anti-swelling, braking and reduction of inflammatory response; the treatment method comprises the following steps: cold compress immediately after injury, pressure dressing, lifting of affected limb and proper braking. It can also be used for treating pain, and by acupoint application and acupuncture. In the middle stage: early stage to the substantial disappearance of symptoms, mainly manifested as pain, swelling, dysfunction. The treatment principle is as follows: improving blood and lymph circulation, promoting tissue metabolism, promoting absorption of blood stasis and exudation, and accelerating regeneration and repair. The treatment method comprises the following steps: comprehensive treatment method and functional exercise. And (3) later stage: the injury is basically repaired, and the pain and swelling basically disappear, but the function is not completely recovered. The main manifestations are pain during exercise, no recovery of muscle strength, and the severe cases may cause the injured part to be stiff and the movement to be limited due to tissue adhesion and scar contraction. The treatment principle is as follows: strengthen and restore the function of muscles and joints, soften scars and release adhesion. The treatment method comprises the following steps: mainly adopts massage, physical therapy and functional exercise, and is properly matched with medicaments for treatment, such as external application of old injury medicaments or fumigation and washing of erythrina bark medicaments.
The pathological changes of chronic injury are mainly degeneration and hyperplasia, and the change of tissue morphology and function is caused by local metabolic disturbance. The main performance is as follows: local soreness, weakness, limited activity, local coolness and the like, and has the characteristic of repeated attack. The treatment principle is as follows: improve the blood circulation of the injured part, promote the metabolism of tissues and reasonably arrange the local load. The treatment method comprises the following steps: consistent with acute injury, intermediate and post-treatment methods, special attention should be paid to functional exercise to maintain exercise levels.
The existing external cold compress gel is generally composed of water, carbomer plant extract and other raw materials and a plastic coat, and a cooling substance does not contain components which play pharmacological, immunological or metabolic roles.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides an external cold compress gel for closed soft tissues, which better overcomes the problems and the defects in the prior art.
In order to achieve the purpose, the invention adopts the following technical scheme: the paint is prepared by mixing the following raw materials in parts by weight: 0.1 to 300 parts of mirabilite, 0.1 to 300 parts of borneol, 0.1 to 300 parts of frankincense, 0.1 to 100 parts of myrrh, 0.1 to 100 parts of angelica dahurica, 1 to 500 parts of dragon's blood, 1 to 500 parts of sodium alginate, 2 to 1000 parts of collagen, 2 to 1000 parts of pseudo-ginseng and 0 to 1500 parts of purified water.
Further preferably, the material is prepared by mixing the following raw materials in parts by weight: 50-300 parts of mirabilite, 50-300 parts of borneol, 50-300 parts of frankincense, 10-100 parts of myrrh, 10-100 parts of radix angelicae, 50-500 parts of dragon's blood, 50-500 parts of sodium alginate, 2-1000 parts of collagen, 2-1000 parts of pseudo-ginseng and 0-1500 parts of purified water.
Further preferably, the material is prepared by mixing the following raw materials in parts by weight: 50 parts of mirabilite, 50 parts of borneol, 100 parts of frankincense, 10 parts of myrrh, 10 parts of angelica dahurica, 50 parts of dragon's blood, 50 parts of sodium alginate, 800 parts of collagen, 50 parts of pseudo-ginseng and 0-1500 parts of purified water.
Preferably, the sodium alginate and the collagen are subjected to a crosslinking reaction.
Preferably, the dosage form of the external medicine is a patch.
Preferably, the dosage form of the external medicine is gel.
Preferably, the most suitable time for cold compress is 48 hours after injury, and the cold compressed part is soft tissue.
Preferably, the purified water is deionized water or distilled water.
Compared with the prior art, the invention has the beneficial effects that:
(1) the invention takes sodium alginate and collagen as carriers, and is matched with borneol, frankincense, myrrh, angelica dahurica, dragon's blood and some natural high molecular substances, and the effective components penetrate into the skin by applying a transdermal absorption process to achieve the effect of cooling. The gel is applied to the parts of body, such as burns, scalds, incised wounds, frostbites, skin ulcers, nasal cavities, bedsores, after operations and the like in an external application mode, the effective components travel along with the channels and collaterals, and the gel is applied to wound wounds to achieve the effects of stopping bleeding and diminishing inflammation, integrates the functions of astringency and repair, quickly achieves the effects of wound inflammation and exudate adsorption and drying, repairs and heals scabs, shortens the treatment course, does not enter the digestive system in vivo, and has no any injury or toxic or side effect.
(2) The cooling substance does not contain a component that exerts a pharmacological, immunological, or metabolic effect.
Drawings
FIG. 1 is a schematic representation of the pain sensation of 500 patients in example 1 of the topical cold compress gel for occlusive soft tissue of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The externally applied cold compress gel for the closed soft tissue is prepared by mixing the following raw materials in parts by weight:
0.1 to 300 parts of mirabilite, 0.1 to 300 parts of borneol, 0.1 to 300 parts of frankincense, 0.1 to 100 parts of myrrh, 0.1 to 100 parts of angelica dahurica, 1 to 500 parts of dragon's blood, 1 to 500 parts of sodium alginate, 2 to 1000 parts of collagen, 2 to 1000 parts of pseudo-ginseng and 0 to 1500 parts of purified water.
Mirabilite: it is externally used to clear heat and relieve swelling.
Pseudo-ginseng: disperse blood stasis, stop bleeding, resolve swelling and alleviate pain.
Borneol: inducing resuscitation and refreshing mind, clearing heat and removing toxic substances, and Borneolum is easily absorbed by mucosa and subcutaneous tissue, and combined with glucuronic acid in vivo and then discharged.
Frankincense: promote blood circulation, move qi and alleviate pain, resolve swelling and promote tissue regeneration.
Myrrh: dispel stasis, relieve pain, resolve swelling and promote tissue regeneration.
Radix angelicae: dispel wind, dry dampness, resolve swelling and alleviate pain. It can be used for treating headache, supercilium pain, odontalgia, nasosinusitis, cold-dampness, abdominal pain, intestinal wind, hemorrhoid, leucorrhea with red and white discharge, carbuncle, skin ulcer, pruritus, scabies, and tinea.
Dragon's blood: promoting blood circulation, relieving pain, removing blood stasis, stopping bleeding, healing sore, and promoting granulation.
Example 1:
50 parts of mirabilite, 50 parts of borneol, 100 parts of frankincense, 10 parts of myrrh, 10 parts of angelica dahurica, 50 parts of dragon's blood, 50 parts of sodium alginate, 800 parts of collagen, 50 parts of pseudo-ginseng and 0-1500 parts of purified water; can be used for cold compress physiotherapy of burn, scald, incised wound, cold injury, skin ulcer, nasal cavity, decubital ulcer, and postoperative. Only for closed soft tissue.
The using method comprises the following steps: the product is externally used, and is suitable for cold compress physiotherapy of various parts such as burn, scald, incised wound, cold injury, skin ulcer, nasal cavity, bedsore, postoperative and the like. The cold compress gel is replaced every 12 hours, and substances and liquefied substances remained on the wound surface are wiped off before replacement.
As shown in figure 1, 500 patients in clinical treatment are cold compress physiotherapy at postoperative parts, cold compress gel is replaced every 12 hours, and substances and liquefied substances remained on the wound surface are wiped off before replacement; the pain feeling after cold compress of the gel is obviously improved by 484 persons, the percentage is 96.8%, the pain feeling is obviously relieved after 3 days of conditioning, and the phenomenon of no semen collection is reduced.
The external cold compress gel for the closed soft tissue selects pure natural traditional Chinese medicine raw materials, is safe to use, is simple and convenient to operate, and has no toxic or side effect; meanwhile, the external cold compress gel for the closed soft tissue provided by the invention has the advantages of low cost, low requirement on medical technical environment and simple nursing.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (8)

1. A topical cold compress gel for occlusive soft tissue, comprising: the paint is prepared by mixing the following raw materials in parts by weight:
0.1 to 300 parts of mirabilite, 0.1 to 300 parts of borneol, 0.1 to 300 parts of frankincense, 0.1 to 100 parts of myrrh, 0.1 to 100 parts of angelica dahurica, 1 to 500 parts of dragon's blood, 1 to 500 parts of sodium alginate, 2 to 1000 parts of collagen, 2 to 1000 parts of pseudo-ginseng and 0 to 1500 parts of purified water.
2. The externally applied cold compress gel for the closed soft tissue as claimed in claim 1, which is prepared by mixing the following raw materials in parts by weight:
50-300 parts of mirabilite, 50-300 parts of borneol, 50-300 parts of frankincense, 10-100 parts of myrrh, 10-100 parts of radix angelicae, 50-500 parts of dragon's blood, 50-500 parts of sodium alginate, 2-1000 parts of collagen, 2-1000 parts of pseudo-ginseng and 0-1500 parts of purified water.
3. The externally applied cold compress gel for the closed soft tissue as claimed in claim 1, which is prepared by mixing the following raw materials in parts by weight: 50 parts of mirabilite, 50 parts of borneol, 100 parts of frankincense, 10 parts of myrrh, 10 parts of angelica dahurica, 50 parts of dragon's blood, 50 parts of sodium alginate, 800 parts of collagen, 50 parts of pseudo-ginseng and 0-1500 parts of purified water.
4. The topical cold compress gel for occlusive soft tissue according to claim 1, wherein the sodium alginate and collagen undergo a cross-linking reaction.
5. A topical cold compress gel for occlusive soft tissue according to claims 1 to 4, wherein: the dosage form of the external medicine is a patch.
6. A topical cold compress gel for occlusive soft tissue according to claims 1 to 4, wherein: the dosage form of the external medicine is gel.
7. A topical cold compress gel for occlusive soft tissue according to claims 1 to 4, wherein: the most suitable cold compress time is 48 hours after injury, and the cold compress part is soft tissue.
8. A topical cold compress gel for occlusive soft tissue according to claims 1 to 4, wherein: the purified water is deionized water or distilled water.
CN202011235497.7A 2020-11-06 2020-11-06 External cold compress gel for closed soft tissue Pending CN112206272A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113350321A (en) * 2021-07-28 2021-09-07 崇州浩康疼痛康复医院(普通合伙) Collateral-dredging health-care patch for treating neck, shoulder, waist and leg pains and preparation method thereof

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CN108310161A (en) * 2018-05-11 2018-07-24 高庆德 A kind of external skin soft tissue injury medicine and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN101703649A (en) * 2009-10-16 2010-05-12 西安千禾药业有限责任公司 Chinese patent medicament for treating bone traumatism and preparation process thereof
CN101874905A (en) * 2009-12-02 2010-11-03 淄博高新区联创科技服务中心 Medicament-carrying tissue engineering hydrogel
CN102670895A (en) * 2011-03-11 2012-09-19 邴守兰 Chinese medicinal composition for treating joint traumatic synovitis and preparation method thereof
CN107050242A (en) * 2017-04-24 2017-08-18 河南科技学院 Treat Chinese medicine composition, the preparation method and applications of acute soft tissue injury
CN108310161A (en) * 2018-05-11 2018-07-24 高庆德 A kind of external skin soft tissue injury medicine and preparation method thereof

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Title
周洪成: "跌打七厘片治疗软组织损伤39例临床疗效观察", 《临床合理用药杂志》 *
徐肇先，等: "自制"软伤Ⅰ号膏"外敷治疗慢性膝关节软组织劳损52例", 《上海中医药杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113350321A (en) * 2021-07-28 2021-09-07 崇州浩康疼痛康复医院(普通合伙) Collateral-dredging health-care patch for treating neck, shoulder, waist and leg pains and preparation method thereof

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Application publication date: 20210112