CN114010669A - Ointment for removing putrefaction and promoting tissue regeneration and preparation method and application thereof - Google Patents
Ointment for removing putrefaction and promoting tissue regeneration and preparation method and application thereof Download PDFInfo
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- CN114010669A CN114010669A CN202111503280.4A CN202111503280A CN114010669A CN 114010669 A CN114010669 A CN 114010669A CN 202111503280 A CN202111503280 A CN 202111503280A CN 114010669 A CN114010669 A CN 114010669A
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a slough-removing and granulation-promoting ointment and a preparation method and application thereof. The raw materials of the ointment for removing slough and promoting granulation comprise: calamine, gypsum (calcined), nacre powder (calcined), gypsum rubrum powder (calcined), centella asiatica, borax, borneol and ointment matrix. The ointment has the effects of promoting tissue regeneration, promoting wound healing, promoting pus discharge, drawing out toxin, clearing heat and removing putrefaction, has the mutual compatibility and synergistic effect of all the medicinal materials, and has definite curative effect on the aspects of promoting the physiological healing of difficult-to-heal wound, reducing the formation of pathological scar, improving the healing speed and the healing quality of the wound and the like. The external ointment can be used for treating various difficult-to-heal wound surfaces and promoting skin growth, and has the advantages of good treatment effect, quick response and obvious effects of treating both symptoms and root causes, preventing relapse after healing and leaving no scars, wherein the difficult-to-heal wound surfaces include diabetic foot, burn and scald, lower limb venous ulcer, various postoperative wound surfaces are not healed, pressure sore and the like. Clinical practice shows that the invention can be used as a first-line medicament for treating wound surfaces in hospitals.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a slough-removing and granulation-promoting ointment and a preparation method and application thereof.
Background
Chronic refractory wound surfaces, such as skin and subcutaneous tissue defects caused by diabetes, arterial insufficiency, venous reflux disorder, compression, radiation injury, trauma and other causes, often show the characteristics of difficult healing, easy relapse and the like due to local blood circulation disorder, ischemia and anoxia, local skin dystrophy and the like. The ulcer wound surface caused by the traditional Chinese medicine belongs to the category of ulcer in the traditional Chinese medicine. The chronic refractory wound is a common and frequently-occurring surgical disease, has complex etiology, prolongs the course of disease for months or even years, is not cured, is easy to relapse after healing, has a risk of canceration when the chronic refractory wound is not cured for a long time, and has heavy medical burden, thus becoming one of the difficulties in clinical treatment. With the progress of population aging in China, chronic refractory wounds become more common senile diseases, and the incidence of the chronic refractory wounds in China is statistically obviously increased in nearly 10 years compared with the ninety years in the last century, so that the chronic refractory wounds become one of the common clinical diseases and frequently encountered diseases.
Western medicine focuses on the etiological treatment of chronic intractable wounds, such as controlling blood sugar, improving blood circulation, etc.; secondly, the traditional Chinese medicine preparation is used for preventing and controlling wound infection, protecting the wound and naturally healing the wound, but the total clinical curative effect is not ideal. Especially, infectious wounds cause prolonged pain to patients due to poor local blood supply, poor cellular metabolic function, slow granulation and growth rate, resulting in loss of working ability and reduced quality of life. The traditional Chinese medicine dialectical treatment has the unique advantages of promoting the physiological healing of chronic refractory wound surfaces, reducing pathological scar formation, improving the healing speed and healing quality of the wound surfaces and the like, and has good curative effect and small side effect. Therefore, the method for searching and developing the medicine for treating chronic refractory wounds from the traditional Chinese medicine has good development potential and important scientific value.
Therefore, it is urgently needed to provide a slough-removing and granulation-promoting ointment with good and quick curative effect, which can achieve the obvious effects of treating both principal and secondary aspects of diseases, preventing relapse after healing and leaving no scars, so as to solve the problems.
Disclosure of Invention
The invention aims to provide an ointment for removing slough and promoting granulation, which is an external ointment with the functions of astringing and stopping bleeding, promoting blood circulation to remove blood stasis, detoxifying and healing sore, removing slough and promoting granulation, can be used for treating difficult wound surfaces such as various ulcers, various postoperative wound surfaces unhealed, pressure sore and the like, promotes skin growth, has good curative effect and quick response, and has obvious effects of treating both principal and secondary aspect of disease, preventing relapse and leaving no scars after healing.
In order to achieve the purpose, the invention provides a putrefaction-removing and granulation-promoting ointment which comprises the following raw materials in parts by weight: 10-50 parts of calamine, 70-130 parts of gypsum (calcined), 10-30 parts of nacre powder (calcined), 10-30 parts of gypsum rubrum powder (calcined), 70-130 parts of borax, 1-10 parts of borneol, 10-30 parts of centella asiatica and 770 parts of ointment matrix 640-.
Further, the raw materials of the ointment for removing slough and promoting granulation comprise, by weight: 20-40 parts of calamine, 90-110 parts of calcined gypsum, 15-25 parts of calcined nacre powder, 15-25 parts of calcined gypsum powder, 90-110 parts of borax, 3-8 parts of borneol, 15-25 parts of centella asiatica and 730 parts of ointment matrix 680-.
Further, the raw materials of the ointment for removing slough and promoting granulation comprise, by weight: 30 parts of calamine, 100 parts of gypsum (calcined), 20 parts of nacre powder (calcined), 20 parts of gypsum rubrum powder (calcined), 100 parts of borax, 5 parts of borneol, 20 parts of centella asiatica and 705 parts of ointment matrix.
Further, the ointment base comprises the following raw materials in parts by weight: 50-150 parts of liquid paraffin and 800 parts of yellow vaseline.
Further, the ointment base comprises the following raw materials in parts by weight: 80-120 parts of liquid paraffin and 500-700 parts of yellow vaseline.
Further, the ointment base comprises the following raw materials in parts by weight: 105 parts of liquid paraffin and 600 parts of yellow vaseline.
The invention also provides a preparation method of the slough-removing and granulation-promoting ointment, which comprises the following steps:
preparing traditional Chinese medicine powder: pulverizing Galamina, Gypsum Fibrosum (calcined), Concha Margaritifera powder (calcined), Mirabilitum Crystallina powder (calcined), Borneolum Syntheticum, and herba Centellae into fine powder, sieving with 80-100 mesh sieve, and mixing to obtain mixed Chinese medicinal powder; crushing borax into fine powder, and sieving with a 80-100 mesh sieve to obtain borax powder;
preparing a matrix: melting the raw materials of the ointment matrix, stirring, and mixing to obtain matrix;
preparing an ointment: adding the mixed traditional Chinese medicine powder into the melted matrix, stirring until the temperature is reduced to 38-42 ℃, adding the borax powder, stirring uniformly, cooling, and subpackaging to obtain the ointment for removing the necrotic tissue and promoting tissue regeneration.
Further, in the preparation of the matrix, the stirring speed is 100-500 r/min.
Further, in the preparation of the ointment, the stirring speed is 100-500 r/min, and the stirring time is 4-6 h.
Further, the raw materials of the ointment for removing slough and promoting granulation comprise, by weight: 10-50 parts of calamine, 70-130 parts of gypsum (calcined), 10-30 parts of nacre powder (calcined), 10-30 parts of gypsum rubrum powder (calcined), 70-130 parts of borax, 1-10 parts of borneol, 10-30 parts of centella asiatica and 770 parts of ointment matrix 640-; the ointment base comprises the following raw materials in parts by weight: 50-150 parts of liquid paraffin and 800 parts of yellow vaseline.
Further, the raw materials of the ointment for removing slough and promoting granulation comprise, by weight: 20-40 parts of calamine, 90-110 parts of gypsum (calcined), 15-25 parts of nacre powder (calcined), 15-25 parts of gypsum rubrum powder (calcined), 90-110 parts of borax, 3-8 parts of borneol, 15-25 parts of centella asiatica and 730 parts of ointment matrix 680-; the ointment base comprises 80-120 parts of liquid paraffin and 500-700 parts of yellow vaseline.
Furthermore, in the preparation method of the ointment for removing putrefaction and promoting tissue regeneration, the raw materials of the ointment for removing putrefaction and promoting tissue regeneration comprise, by weight: 30 parts of calamine, 100 parts of gypsum (calcined), 20 parts of nacre powder (calcined), 20 parts of gypsum rubrum powder (calcined), 100 parts of borax, 5 parts of borneol, 20 parts of centella asiatica, 105 parts of liquid paraffin and 600 parts of yellow vaseline.
The invention also provides application of the slough-removing and granulation-promoting ointment in medicines for treating difficult-to-heal wound surfaces and promoting skin growth. For example, the application in the treatment of diabetic foot, burn and scald, lower limb venous ulcer, various postoperative wound unhealed wounds and refractory wounds of pressure sores.
The ointment for removing putrefaction and promoting tissue regeneration consists of calamine, gypsum (calcined), nacre powder (calcined), gypsum rubrum powder (calcined), borax, borneol, centella and a matrix. The compendium of materia medica records that the medicines have the functions of astringing to stop bleeding, promoting blood circulation to remove blood stasis, detoxifying and healing sore, removing putrefaction and promoting granulation, and the like. Calamine has effects of pus-expelling, pus-drawing out, putrefaction-removing, and granulation-promoting; gypsum Fibrosum (calcined) has effects of eliminating dampness, promoting granulation, healing sore, and stopping bleeding; concha Margarit powder (calcined) has effects of suppressing hyperactive liver and subsiding yang, eliminating dampness and astringing, but promoting regeneration; gypsum Fibrosum powder (calcined) can be used for external use to clear heat and relieve swelling; removing putrefaction and toxic materials with Borax; centella asiatica clears heat and promotes diuresis, and relieves swelling and detoxifies; borneol has the functions of clearing away heat, relieving pain, resisting corrosion and inducing medicine to enter orifice. The liquid paraffin protects granulation tissues and is beneficial to wound healing; the yellow vaseline keeps the skin moist, so that skin tissues at the wound part keep the optimal state, and the self-repairing capacity of the skin is accelerated; liquid paraffin and yellow vaseline have effects of moistening skin and promoting granulation, and can be used as excipient.
The putrefaction-removing and granulation-promoting ointment provided by the invention improves the tissue microenvironment by promoting qi, activating blood and detoxifying in combination, so that the purposes of acidification, nutrition, wound surface protection, wound surface moisture keeping, immunity regulation, blood circulation promotion, sterilization, bacteriostasis, pain relief and the like are achieved, the wound surface healing is promoted, and scars are prevented from forming. Modern researches show that calamine has strong antibacterial activity, can be combined with cell membranes and membrane proteins of bacteria to destroy the structures of the bacteria, and can destroy enzymes after entering cells and react with DNA (deoxyribonucleic acid) to achieve the antibacterial aim. Gypsum Fibrosum (calcined) has effects of eliminating dampness, promoting granulation, healing sore, and stopping bleeding, and topical Gypsum Fibrosum Preparatum can be used for treating ulcer, eczema, pruritus, scald due to hot water and fire, traumatic hemorrhage, etc. The calcined nacre powder has strong antibacterial effect on the skin, but is rotten and regenerated, and can nourish the face and nourish the skin. The gypsum rubrum powder (calcined) has the functions of purging heat, relaxing bowels, moistening dryness, softening hard masses, clearing fire and relieving swelling, is a preferred medicine for external application to relieve swelling, can promote inflammation absorption and dissipation by external application, and can soften local callus, so that the local callus is easy to peel off and fall off, and the local pressure is fundamentally eliminated (the neurogenic ulcer is prevented from being generated again). Asiaticoside in centella asiatica can promote skin growth, and is used for treating trauma, surgical wound, burn, keloid, scleroderma, etc. Borax has antibacterial, antiseptic and skin mucosa protecting effects, and can be used for washing ulcer and abscess to remove scale. Borneol has the functions of clearing heat, relieving pain, reducing swelling, clearing away heat and toxic material, preventing corrosion and promoting granulation, and has better curative effects on burns, sore and ulcer swelling, unhealing after ulceration and the like.
The invention has the beneficial effects that:
the ointment for removing the necrotic tissue and promoting tissue regeneration has the effects of clearing away heat and toxic materials, relieving swelling and pain, diminishing inflammation and relieving itching, astringing and stopping bleeding, removing the necrotic tissue and promoting tissue regeneration and removing stasis and toxin, and can improve skin pruritus and microcirculation disturbance, repair damaged skin cell tissues and promote skin tissue cell regeneration. The invention is mainly used for treating various ulcers (such as diabetic foot, burn and scald, lower limb venous ulcer), various non-healing wounds after operation, pressure sores and other difficult wound surfaces and promoting skin growth. The invention is prepared from calamine, gypsum (calcined), nacre powder (calcined), gypsum rubrum powder (calcined), centella asiatica, borax, borneol, liquid paraffin and yellow vaseline, has clear treatment rule, reasonable compatibility and synergistic effect of various medicines, has the functions of astringing to stop bleeding, promoting blood circulation to remove blood stasis, detoxifying and healing sore, removing putrefaction, promoting granulation and the like, has good treatment effect and quick response, can achieve the remarkable effects of treating both symptoms and root causes, preventing relapse after healing and not leaving scars, and can be used as a first-line medicine for treating wound surfaces in hospitals by combining clinical practice.
The invention conforms to the traditional Chinese medicine theory, adopts a plurality of traditional Chinese medicines to prepare the ointment, can improve the tissue microenvironment by promoting qi, activating blood and detoxifying, thereby achieving the purposes of removing slough and promoting granulation, and has the efficacy of accelerating tissue repair and skin wound healing. The ointment for removing slough and promoting granulation can promote granulation tissue hyperplasia, reduce inflammatory reaction of wound surface, promote collagen synthesis and capillary angiogenesis, improve local blood circulation, reduce scar formation and promote skin regeneration.
The invention is a pure Chinese medicinal preparation, has little toxic and side effects; the medicine is from nature, is easy to obtain, has low medicine price, and can also reduce the economic burden of patients. By using the ointment of the invention, patients have no pain, the effect is obvious, the treatment process is effectively shortened, and the ointment is suitable for light, medium and severe patients; and has the advantage of no scar left after healing. The invention has simple formula, convenient operation and lower cost. The ointment for removing the necrotic tissue and promoting tissue regeneration has obvious innovativeness on the composition and the preparation process, is fine and soft, has good spreadability, no peculiar smell, safety and reliability, has satisfactory treatment effect, and is a better ointment for treating the wound surface after trauma by external use.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a drawing showing the construction of a rat wound model in test example 1 of the present invention;
FIG. 2 is a graph showing the healing of the wound of a rat in test example 1 of the present invention;
FIG. 3 is a HE slice of skin of a general wound and a burn and scald wound of a rat in test example 2 of the present invention;
FIG. 4 is a graph showing the weight gain of rats in test example 2 of the present invention;
FIG. 5 is a diagram showing a case of healing of a necrotic wound after radical breast cancer surgery in test example 5 of the present invention.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment of the invention provides a slough-removing and granulation-promoting ointment which comprises the following raw materials in parts by weight: calamine, gypsum (calcined), nacre powder (calcined), gypsum rubrum powder (calcined), borax, borneol, centella asiatica, and ointment matrix. The ointment for removing the necrotic tissue and promoting tissue regeneration consists of calamine, gypsum (calcined), nacre powder (calcined), gypsum rubrum powder (calcined), borax, borneol, centella asiatica and a matrix, and the combination of the medicines ensures that the efficacies of the medicines generate synergistic action, so that the ointment can be used for treating various ulcers, various wounds which are difficult to heal after operation, pressure sores and other difficult wound surfaces, can promote the growth of skin, and has good and quick curative effect.
The healing rule of the skin ulcer wound surface is 'slough and muscle regeneration' and 'muscle flat skin growth'. The traditional Chinese medicine is prepared by selecting three traditional Chinese medicines of gypsum (calcined), nacre powder (calcined) and centella asiatica and the like with the functions of promoting tissue regeneration and promoting wound healing according to the traditional Chinese medicine theory and combining calamine, gypsum rubrum powder (calcined), borax and borneol which have the functions of pus drawing, toxin drawing, heat clearing and decay removing. The components with the prescription have definite curative effects on promoting the physiological healing of the wound surface which is difficult to heal, reducing the formation of pathological scar, improving the healing speed and the healing quality of the wound surface and the like. The invention has clear treatment rules, has the functions of astringing to stop bleeding, promoting blood circulation to remove blood stasis, detoxifying and healing sore, removing putrefaction and promoting granulation and the like, and has the effect of treating the pyocutaneous disease by the mutual compatibility and the synergistic action of all the medicinal materials. The external ointment can be used for treating various difficult-to-heal wound surfaces and promoting skin growth, and has the advantages of good treatment effect, quick response and obvious effects of treating both symptoms and root causes, preventing relapse after healing and leaving no scars, wherein the difficult-to-heal wound surfaces include diabetic foot, burn and scald, lower limb venous ulcer, various postoperative wound surfaces are not healed, pressure sore and the like. Clinical practice shows that the traditional Chinese medicine can be used as a first-line medicine for treating wound surfaces in hospitals.
Further, in the ointment for removing putrefaction and promoting tissue regeneration, the weight parts of the calamine can be 10 parts, 20 parts, 30 parts, 40 parts or 50 parts; the gypsum (calcined) may be 70 parts, 80 parts, 90 parts, 100 parts, 110 parts, 120 parts or 130 parts by weight; the weight portion of the nacre powder (calcined) can be 10 portions, 15 portions, 20 portions, 25 portions or 30 portions; the weight parts of the gypsum rubrum powder (calcined) can be 10 parts, 15 parts, 20 parts, 25 parts or 30 parts; the borax can be 70 parts, 80 parts, 90 parts, 100 parts, 110 parts, 120 parts or 130 parts by weight; the borneol can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts by weight; the snowflake can be 10 parts, 15 parts, 20 parts, 25 parts or 30 parts by weight; the ointment base may be 640 parts, 660 parts, 680 parts, 700 parts, 710 parts, 730 parts, 750 parts, 760 parts or 770 parts by weight.
Further, the ointment base includes liquid paraffin and yellow vaseline. In detail, in the ointment base, the liquid paraffin may be present in an amount of 50 parts, 60 parts, 70 parts, 80 parts, 90 parts, 100 parts, 110 parts, 120 parts, 130 parts, 140 parts, or 150 parts by weight; the yellow vaseline may be 400 parts, 450 parts, 500 parts, 550 parts, 600 parts, 650 parts, 700 parts, 750 parts or 800 parts by weight.
The preparation method of the ointment for removing slough and promoting granulation comprises the following steps:
preparing traditional Chinese medicine powder: respectively crushing calamine, gypsum (calcined), nacre powder (calcined), gypsum powder (calcined), borneol and centella into fine powder according to the weight parts, sieving by a sieve of 80-100 meshes, and uniformly mixing to obtain mixed traditional Chinese medicine powder; crushing the borax in parts by weight into fine powder, and sieving the fine powder with a sieve of 80-100 meshes to obtain borax powder;
preparing a matrix: melting the raw materials of the ointment matrix according to the parts by weight, stirring at the stirring speed of 100-500 r/min, and uniformly mixing to obtain the matrix;
preparing an ointment: adding the mixed traditional Chinese medicine powder into the melted matrix, stirring at the speed of 100-500 r/min for 4-6h, cooling to about 40 ℃, adding the borax powder, stirring uniformly, cooling, and subpackaging to obtain the ointment for removing the necrotic tissue and promoting tissue regeneration.
The ointment for removing slough and promoting granulation can be applied to medicines for treating difficult-to-heal wound surfaces and promoting skin growth. For example, the application of the composition in the preparation of medicines for treating intractable wounds such as diabetic foot, burn and scald, lower limb venous ulcer, various postoperative wounds which are not healed and pressure sore.
In the invention, the application method of the slough-removing and granulation-promoting ointment comprises the following steps: it is applied topically to affected parts.
The invention is described in further detail with reference to a part of the test results, which are described in detail below with reference to specific examples.
Example 1
The embodiment provides a slough-removing and tissue regeneration-promoting ointment, which comprises the following components in parts by weight: 30 parts of calamine, 100 parts of gypsum (calcined), 20 parts of nacre powder (calcined), 20 parts of gypsum rubrum powder (calcined), 100 parts of borax, 5 parts of borneol, 20 parts of centella asiatica, 105 parts of liquid paraffin and 600 parts of yellow vaseline.
The preparation method of the ointment for removing slough and promoting granulation comprises the following steps:
preparing traditional Chinese medicine powder: pulverizing the above parts by weight of calamine, gypsum (calcined), nacre powder (calcined), gypsum rubrum powder (calcined), borneol and centella into fine powder, sieving with a 80-100 mesh sieve, and mixing uniformly to obtain mixed traditional Chinese medicine powder; crushing the borax in parts by weight into fine powder, and sieving the fine powder with a sieve of 80-100 meshes to obtain borax powder;
preparing a matrix: melting the above raw materials (liquid paraffin and yellow vaseline) in parts by weight, stirring at 100r/min, and mixing to obtain matrix;
preparing an ointment: adding the mixed Chinese medicinal powder into the melted matrix, stirring at 500r/min for 2h until the temperature is reduced to about 40 deg.C, adding the borax powder, stirring at 500r/min for 2h, cooling, and packaging to obtain ointment with effects of removing necrotic tissue and promoting granulation.
The ointment for removing slough and promoting granulation is applied to ulcer treatment, including diabetic foot, burn and scald, lower limb venous ulcer, various postoperative wound surfaces unhealed and refractory wound surfaces of pressure sore.
Example 2
The embodiment provides a slough-removing and tissue regeneration-promoting ointment, which comprises the following components in parts by weight: 10 parts of calamine, 70 parts of gypsum (calcined), 10 parts of nacre powder (calcined), 10 parts of gypsum rubrum powder (calcined), 70 parts of borax, 1 part of borneol, 10 parts of centella asiatica, 300 parts of liquid paraffin and 519 parts of yellow vaseline.
The preparation method of the ointment for removing slough and promoting granulation comprises the following steps:
preparing traditional Chinese medicine powder: pulverizing the above parts by weight of calamine, gypsum (calcined), nacre powder (calcined), gypsum rubrum powder (calcined), borneol and centella into fine powder, sieving with a 80-100 mesh sieve, and mixing uniformly to obtain mixed traditional Chinese medicine powder; crushing the borax in parts by weight into fine powder, and sieving the fine powder with a sieve of 80-100 meshes to obtain borax powder;
preparing a matrix: melting the above raw materials (liquid paraffin and yellow vaseline) in parts by weight, stirring at 100r/min, and mixing to obtain matrix;
preparing an ointment: adding the mixed Chinese medicinal powder into the melted matrix, stirring at 500r/min for 2h until the temperature is reduced to about 40 deg.C, adding the borax powder, stirring at 500r/min for 2h, cooling, and packaging to obtain ointment with effects of removing necrotic tissue and promoting granulation.
The ointment for removing slough and promoting granulation is applied to ulcer treatment, including diabetic foot, burn and scald, lower limb venous ulcer, various postoperative wound surfaces unhealed and refractory wound surfaces of pressure sore.
Example 3
The embodiment provides a slough-removing and tissue regeneration-promoting ointment, which comprises the following components in parts by weight: 50 parts of calamine, 130 parts of gypsum (calcined), 30 parts of nacre powder (calcined), 30 parts of gypsum rubrum powder (calcined), 130 parts of borax, 10 parts of borneol, 30 parts of centella asiatica, 50 parts of liquid paraffin and 540 parts of yellow vaseline.
The preparation method of the ointment for removing slough and promoting granulation comprises the following steps:
preparing traditional Chinese medicine powder: pulverizing the above parts by weight of calamine, gypsum (calcined), nacre powder (calcined), gypsum rubrum powder (calcined), borneol and centella into fine powder, sieving with a 80-100 mesh sieve, and mixing uniformly to obtain mixed traditional Chinese medicine powder; crushing the borax in parts by weight into fine powder, and sieving the fine powder with a sieve of 80-100 meshes to obtain borax powder;
preparing a matrix: melting the above raw materials (liquid paraffin and yellow vaseline) in parts by weight, stirring at 100r/min, and mixing to obtain matrix;
preparing an ointment: adding the mixed Chinese medicinal powder into the melted matrix, stirring at 500r/min for 2h until the temperature is reduced to about 40 deg.C, adding the borax powder, stirring at 500r/min for 2h, cooling, and packaging to obtain ointment with effects of removing necrotic tissue and promoting granulation.
The ointment for removing slough and promoting granulation is applied to ulcer treatment, including diabetic foot, burn and scald, lower limb venous ulcer, various postoperative wound surfaces unhealed and refractory wound surfaces of pressure sore.
Example 4
The embodiment provides a slough-removing and tissue regeneration-promoting ointment, which comprises the following components in parts by weight: 20 parts of calamine, 80 parts of gypsum (calcined), 15 parts of nacre powder (calcined), 15 parts of gypsum rubrum powder (calcined), 80 parts of borax, 5 parts of borneol, 15 parts of centella asiatica, 100 parts of liquid paraffin and 670 parts of yellow vaseline.
The preparation method of the ointment for removing slough and promoting granulation comprises the following steps:
preparing traditional Chinese medicine powder: pulverizing the above parts by weight of calamine, gypsum (calcined), nacre powder (calcined), gypsum rubrum powder (calcined), borneol and centella into fine powder, sieving with a 80-100 mesh sieve, and mixing uniformly to obtain mixed traditional Chinese medicine powder; crushing the borax in parts by weight into fine powder, and sieving the fine powder with a sieve of 80-100 meshes to obtain borax powder;
preparing a matrix: melting the above raw materials (liquid paraffin and yellow vaseline) in parts by weight, stirring at 100r/min, and mixing to obtain matrix;
preparing an ointment: adding the mixed Chinese medicinal powder into the melted matrix, stirring at 500r/min for 2h until the temperature is reduced to about 40 deg.C, adding the borax powder, stirring at 500r/min for 2h, cooling, and packaging to obtain ointment with effects of removing necrotic tissue and promoting granulation.
The ointment for removing slough and promoting granulation is applied to ulcer treatment, including diabetic foot, burn and scald, lower limb venous ulcer, various postoperative wound surfaces unhealed and refractory wound surfaces of pressure sore.
Example 5
The embodiment provides a slough-removing and tissue regeneration-promoting ointment, which comprises the following components in parts by weight: 40 parts of calamine, 120 parts of gypsum (calcined), 25 parts of nacre powder (calcined), 25 parts of gypsum rubrum powder (calcined), 120 parts of borax, 5 parts of borneol, 25 parts of centella asiatica, 100 parts of liquid paraffin and 540 parts of yellow vaseline.
The preparation method of the ointment for removing slough and promoting granulation comprises the following steps:
preparing traditional Chinese medicine powder: pulverizing the above parts by weight of calamine, gypsum (calcined), nacre powder (calcined), gypsum rubrum powder (calcined), borneol and centella into fine powder, sieving with a 80-100 mesh sieve, and mixing uniformly to obtain mixed traditional Chinese medicine powder; crushing the borax in parts by weight into fine powder, and sieving the fine powder with a sieve of 80-100 meshes to obtain borax powder;
preparing a matrix: melting the above raw materials (liquid paraffin and yellow vaseline) in parts by weight, stirring at 100r/min, and mixing to obtain matrix;
preparing an ointment: adding the mixed Chinese medicinal powder into the melted matrix, stirring at 500r/min for 2h until the temperature is reduced to about 40 deg.C, adding the borax powder, stirring at 500r/min for 2h, cooling, and packaging to obtain ointment with effects of removing necrotic tissue and promoting granulation.
The ointment for removing slough and promoting granulation is applied to ulcer treatment, including diabetic foot, burn and scald, lower limb venous ulcer, various postoperative wound surfaces unhealed and refractory wound surfaces of pressure sore.
In the invention, the putrefaction-removing and granulation-promoting ointments prepared in examples 1-5 are packaged by medical plastic box packages, and each box contains 20 g of ointment.
The ointment for removing putrefaction and promoting tissue regeneration prepared in the embodiments 1-5 of the invention has the advantages of fine paste, good fluidity, good spreadability, good transdermal property, comfortable, soft, silky and non-irritant skin after being wiped on the body, safety and reliability.
Example 6
The ointment for removing the necrotic tissue and promoting tissue regeneration in the embodiment 1 is applied to the wound surface of the burn and the scald: the burn and scald patient cleans the wound surface, a small amount of ointment is dipped in gauze or cotton and evenly smeared on the wound surface, the area is large, exposure treatment is needed, the dressing is changed for 2-3 times every day, the acute pain can be eliminated by smearing the ointment, the pain of the wound surface disappears after three days, the exudation is obviously reduced by smearing the ointment for 1 day, the wound surface is gradually preserved, the shallow 2-degree burn heals within 10 days (d), the deep 2-degree burn heals within 2 weeks, and the 3-degree burn heals within 3 weeks without scars.
The ointment for removing slough and promoting granulation in the embodiment 1 is applied to traumatic injury, eczema, chilblain and various postoperative wound surfaces: the ointment is uniformly applied to the wound surface of patients suffering from traumatic injury, eczema, chilblain and various postoperative wound surfaces, the thickness of the ointment is about 1mm, the dressing change is carried out for 1 time every day, residual medicines and liquefied substances on the wound surface are wiped off by the ointment during dressing change, then the ointment is applied according to the method, the ointment is applied to the surface and the periphery of a scab part of the wound surface after the wound surface is scabbed until the scab automatically falls off to form new skin, the ointment is continuously applied to the surface and the periphery of the new skin, the wound surface is exposed to the optimal medicinal effect, the ointment is applied once every day after the color of the surface of the new skin is lightened or close to the color of the normal skin, the medicine is stopped after the skin recovers the normal skin quality, and the skin is beautiful, moist, elastic, free of pigmentation and free of scars after the healing.
Test example 1
The ointment for removing slough and promoting granulation of the invention in the embodiment 1 is used for carrying out experiments on common wounds of rats and burn and scald wounds, and is compared with a control group to test the skin growth effect of the ointment of the invention.
Rats were anesthetized (shutitan: doximel: physiological saline volume ratio 1.6:0.4:8) at a dose of 0.25-0.3mL/100 g. After anesthesia, rats were fixed, depilated and sterilized on the back. As shown in fig. 1, general wound and burn and scald wound models are constructed in the area a and the area b respectively. Marking an area of 1cm multiplied by 1cm in the area a by using a marking pen, cutting the skin to a fascia layer, cutting the skin in the area a, and carrying out sterile application and coating treatment to form a rat full-layer skin defect open wound (common wound) model. ② taking a plastic sample cell with the bottom surface of 1cm multiplied by 1cm, removing the bottom end and sterilizing. Fixing the sample pool on the area b of the skin of the rat, injecting 2mL of newly boiled hot water, timing for 30s, quickly removing the hot water by using a pipette, and carrying out sterile application coating treatment to form a skin burn and scald model of the rat. FIG. 1 is a rat wound model construction diagram, wherein A is a model construction schematic diagram (a: general wound; b: burn and scald wound); and B is rat wound model (a: general wound surface; B: burn and scald wound surface).
The rats were randomly divided into 4 groups of 8 rats each. The general wound surface and the burn and scald wound surface of a rat are respectively given 1g of blank matrix yellow vaseline, positive control drug Jingwanhong ointment and slough-removing and granulation-promoting ointment, 1 group of the rats do not take the drug as blank control, and are fixed by aseptic application and changed with the drug every day.
The body weight of the rats was weighed every 2 days, and the wound area was measured. Pathological scoring was performed on day 10 according to table 1, and 2 rats were sacrificed per group to make hematoxylin-eosin (HE) stained pathological sections. In addition, wound healing rates were calculated on days 4, 10, and 16. The wound healing rate is the initial area of the wound-the area of the wound/the initial area of the wound × 100%.
TABLE 1 pathological histology scoring standard for burn and scald
All statistical data were processed using Graphpad Prism 8 software, mean ± standard deviation was expressed as (χ ± s), single-factor analysis of variance or multiple t-test between groups, and P <0.05 indicated statistical differences.
And after the wound surface model is established, drawing a scar area time change curve. The results are shown in fig. 2 as a, B, the scar area reduction rate: the final scar area of the slough-removing and granulation-promoting ointment is far smaller than that of a blank control group and a matrix group (yellow vaseline). As shown in fig. 2C, after 10 days of administration, the blank control group generally reduced the area of the wound surface, had swollen skin at the edges, and had rough and uneven yellow crust skin in the middle, while the burn wound surface had deep color and hard texture, and the crust skin around had a tendency to fall off, but had tissue adhesion; the yellow vaseline group has no swelling condition on the skin of the general wound surface, the healing trend of the wound surface is normal, the scabbing color of the burn and scald wound surface is light, and the edge of the wound surface is smooth; the positive control (Jingwanhong ointment) and the putrefaction-removing and granulation-promoting ointment have decrustation on the wound surface of the burn and scald, the wound surface is obviously reduced, and the texture is soft. After 20 days of administration, the wound surface of each group of rats had healed, but the residual area of the scar: blank control, yellow Vaseline, Jingwanhong ointment, slough-removing and tissue regeneration-promoting ointment, and the general wound skin of the slough-removing and tissue regeneration-promoting ointment group is completely healed, and scar residues are hardly observed.
FIG. 2 is a diagram of the healing of rat wound; wherein, A: time change curve of scar area of wound surface (n is 6); b: time change curve of scar area of wound surface, P <0.01(n ═ 6); c: the healing condition of the wound surface of the rat is 0, 10 and 20 days (black line: general wound surface, yellow line: burn and scald wound surface).
In addition, the healing rates were calculated for various wounds on days 4, 10, and 16. As shown in table 2, the healing rate of the general wound surface of the jingwanhong ointment group and the necrotic tissue removing and granulation promoting ointment group was significantly higher than that of the blank control group and yellow Vaseline group (P <0.0001) on days 10 and 16. On day 16, the healing rate of the ointment group for removing the necrotic tissue and promoting tissue regeneration reaches 77.77 percent, which is higher than that of the ointment group for removing the necrotic tissue and promoting tissue regeneration (67.55 percent); but the healing rate of the blank control group and the yellow vaseline group is only about 50%. The healing rate of the burn and scald wound is shown in table 3, and the wound healing rate of the ointment group for removing slough and promoting granulation is obviously higher than that of the other groups. On the 16 th day, the healing rate of the burn and scald wound surfaces of the ointment group for removing the necrotic tissue and promoting tissue regeneration reaches 67.79 percent, which is much higher than that of each control group (P is less than 0.0001).
TABLE 2 general wound healing Rate
| Group of | Day 4 | |
|
| Blank control | 10.29±3.06 | 24.48±4.01 | 50.30±2.91 |
| Yellow Vaseline | 5.08±9.03 | 28.35±6.82 | 52.00±3.83 |
| Jingwanhong ointment | 12.88±1.84△ | 45.25±3.58****△ΔΔ△ | 67.55±3.00****△ΔΔ△ |
| Ointment for removing putrefaction and promoting tissue regeneration | 16.98±3.88△Δ△ | 50.92±2.33****△ΔΔ△ | 77.77±4.40****△ΔΔ△ |
Note:****P<0.0001, compared to a blank control group;ΔP<0.05,ΔΔΔP<0.001，ΔΔΔΔP<0.0001, comparison with yellow Vaseline group (n ═ 6, mean. + -. SD,%)
TABLE 3 healing rate of burn and scald wound
Note:*P<0.05，**P<0.01，****P<0.0001, compared to a blank control group;ΔP<0.05，ΔΔΔP<0.001，ΔΔΔΔP<0.0001, compared to yellow petrolatum;○○○P<0.001，○○○○P<0.0001, comparison with Jingwanhong ointment group (n ═ 6, mean ± SD,%)
After 10 days of administration, pathological histological scoring was performed on inflammatory exudation, granulation tissue regeneration and epithelial regeneration repair of the general wound and the burn wound, respectively, according to table 1. As shown in tables 4 and 5, the pathological scores of the slough-removing and granulation-promoting ointment groups were superior to those of the other groups, and were statistically different from those of the blank control group (P <0.01) and yellow Vaseline group (P < 0.05). The pathological scoring result of the burn and scald wound is similar to that of the common wound, the ointment group for removing the necrotic tissue and promoting tissue regeneration is obviously superior to other control groups, and has significant difference (P <0.01) with a blank control group. The putrefaction-removing and granulation-promoting ointment can effectively reduce inflammatory exudation of the wound surface, promote granulation tissue generation and accelerate epithelial regeneration.
Table 4 general wound pathology histology scores
| Group of | Inflammatory exudation | Regeneration of granulation tissue | Epithelial regeneration repair |
| Blank control | 4.8±0.8 | 8.7±1.0 | 1.8±0.4 |
| Yellow Vaseline | 2.8±08*** | 9.8±0.8 | 2.2±0.4 |
| Jingwanhong ointment | 2.2±0.8**** | 10.5±0.5** | 2.5±0.5* |
| Ointment for removing putrefaction and promoting tissue regeneration | 0.7±0.6****△ΔΔ△○○ | 11.3±0.8****△ | 2.8±0.4**△ |
Note:*P<0.05，**P<0.01，***P<0.001，****P<0.0001, compared to a blank control group;ΔP<0.05，ΔΔΔΔP<0.0001, compared to yellow petrolatum;○○P<0.01, compared with Jingwanhong ointment group (n ═ 6, chi + -s)
TABLE 5 burn and scald wound Pathology tissue score
| Group of | Inflammatory exudation | Regeneration of granulation tissue | Epithelial regeneration repair |
| Blank control | 5.5±1.0 | 8.2±1.2 | 1.5±0.6 |
| Yellow Vaseline | 3.5±0.5*** | 9.0±0.9 | 1.8±0.4 |
| Jingwanhong ointment | 2.8±0.8**** | 9.5±0.5 | 2.3±0.5* |
| Ointment for removing putrefaction and promoting tissue regeneration | 1.0±0.6****△ΔΔ△○○ | 10.2±1.2** | 2.7±0.5**△ |
Note: p <0.05, P <0.01, P <0.001, P <0.0001, compared to the blank control; delta P <0.05, delta P <0.0001, compared to yellow petrolatum; o <0.01, compared to the jingwanhong ointment group (n ═ 6, χ ± s)
In addition, HE results (fig. 3) show that the ointment for removing slough and promoting granulation has complete and clear skin structure of the wound surface, complete repair of epidermis and less inflammatory infiltration. The Jingwanhong ointment group has parakeratosis, thickened squamous epithelium, fissured skin and more inflammatory exudation. The yellow vaseline group and the blank control group have skin parakeratosis, and the scaly epithelium of the wound surface, especially the burn wound surface is hyperproliferated and has a large amount of inflammatory exudation; in addition, the skin scabs of the blank control group are not completely removed, the new epidermis under the scabs is not connected, and congestion and swelling occur. These results indicate that the wound healing effect of the slough-removing and granulation-promoting ointment is good, and the ointment can promote wound healing, reduce inflammatory exudation, accelerate tissue repair and restore skin integrity. FIG. 3 is the HE section (scale: 50 μm) of the skin of the rat wound and the burn and scald wound.
The change curve of the body weight of the rats after the administration is observed and recorded (figure 4), the body weight of each group of rats keeps a stable increasing trend, and no significant difference exists. In addition, no obvious toxic or side effect is observed in the medication process, no adverse event occurs, and the putrefaction-removing and tissue regeneration-promoting ointment has good safety and has reference significance for clinical application. Fig. 4 is a graph of the weight gain of rats (n-6).
Test example 2
Clinical treatment tests were conducted on 178 patients with venous leg ulcer by using the ointment for removing necrotic tissue and promoting granulation prepared in example 1 of the present invention, and the results were compared with a control group to test the skin-growing effect of the ointment of the present invention.
Case selection: firstly, the history of varicose veins of lower limbs; secondly, ulcer is locally generated on the lower limbs; ③ sores are difficult to heal and easy to recur. There were 178 cases, 128 of men and 50 of women; age 42-71 years, mean (53.12 ± 6.74) years; the course of the disease is 3-24 months, and the average (10.16+7.24-) month; average area of wound surface (7.3 +/-0.98) cm2. All cases were venous leg ulcers and were examined by color ultrasonography of the lower limbs. Prompting the smooth deep vein.
The treatment method comprises the following steps: the traditional Chinese medicine comprehensive external treatment scheme is adopted, and 8 weeks are observed. Removing the rotten stage: the putrefaction-removing and wound-cleaning method, fumigation and washing method, wet dressing method, winding method and putrefaction-removing and granulation-promoting medicine are selected and applied to the putrefaction-removing and granulation-promoting ointment. The granulation promoting period: fumigating and washing, wet dressing, wound-dressing, and wound-healing ointment (patent No. 202010510918.6).
Removing the rotten stage: the debridement is suitable for the patients with much pus and decayed tissues and difficult to shed, and is carried out on the basis of wound infection control and clear boundary between necrotic tissues and healthy tissues. The slough (necrotic tissue) and unhealthy granulation tissue are cut off one by one until the cut ends are fresh or bleed without obvious pain, and fascia and tendon tissue are protected as much as possible. ② the Chinese medicine fumigation and washing therapy uses intelligent Chinese medicine fumigation instrument to fumigate Chinese medicine. Adding water into a traditional Chinese medicine decoction (300mL provided by a preparation room of the hospital) until the water is 1000-1100 mL, heating, fumigating the affected part with the medicinal liquid steam after the temperature is high (about 40 ℃), and keeping the distance between the affected part and the medicinal liquid to be 25-30 cm so as to be tolerant. And a decay removing stage. Fumigating and washing with Chinese medicinal decoction (cortex Phellodendri, herba Pyrolae, rhizoma Atractylodis, Alismatis rhizoma, herba Lycopodii, etc.) for clearing away heat, promoting diuresis and removing toxic substance. Third, swamp massage (hydropathic compress) is carried out by soaking the decoction with 8 layers of gauze, applying to the affected part without dripping water, and fumigating and washing with the above medicinal materials. It is administered 1 time daily. Fourthly, the traditional Chinese medicine entanglement therapy is adopted, and after the local wound surface is treated, the wide bandage is used for entangling and attaching the affected part and the lower limb. Starting at 3cm below the ulcer surface. Covering the local part by a tile-folding method (the edge of the next layer of bandage is overlapped by 1-2 cm, and the like, and the operation method is similar to tile-folding) until the position of 3cm above the ulcer surface, and fixing by using rubber. Severe infection and Ankle Brachial Index (ABI) <0.7 are contraindications. Fifthly, removing putrefaction and promoting tissue regeneration, and the ointment for removing putrefaction and promoting tissue regeneration is adopted for treatment. Sterilizing the wound surface by conventional method, uniformly spreading appropriate amount of the ointment on sterile gauze (about 3mm in thickness) according to the size of the wound surface, covering with sterile gauze, fixing with adhesive tape, and changing dressing 1 time 1 d.
The granulation promoting period: firstly, a fumigation and washing method, namely, fumigation and washing with traditional Chinese medicine decoction (raw astragalus, angelica, salvia miltiorrhiza, safflower, motherwort and the like) for tonifying qi, activating blood circulation and promoting tissue regeneration, 1 time every day and 30min every time. ② the tissue regeneration promoting stage of traditional Chinese medicine swamp therapy (hydropathic compress therapy) is operated at the same time of putrefaction removing stage. And the tissue regeneration stage operation of the traditional Chinese medicine entanglement therapy is the same as the putrefaction removing stage operation. Fourthly, the wound healing ointment (see patent number: 202010510918.6) is adopted to treat the wound. Sterilizing the wound surface by conventional method, spreading appropriate amount of the ointment on sterile gauze (about 3mm in thickness) according to the size of the wound surface, covering with sterile gauze, and fixing with adhesive tape. 1d dressing change 1 time.
178 patients are cured by 131 patients, 19 patients with obvious effect, 10 patients with effect and 18 patients with no effect, and the effective rate is 89.89%. The healing time is 24-52 days, and the average (24.94 +/-8.65) days. The patients who are not healed in 6 weeks reassess the wound condition, and the treatment is continued by changing the scheme. 4 patients are always not cured and then transferred to hospital, 4 patients are cured by routine skin grafting, and the rest patients are cured by adopting the combination of external treatment and internal treatment of traditional Chinese medicine. Compared with other treatment schemes, patients who apply the wound healing ointment (see patent number: 202010510918.6) with the slough-removing and tissue-regenerating medicine slough-removing and tissue-regenerating ointment and the tissue-regenerating and skin-astringing medicine wound healing ointment in the slough-removing period have obviously shortened healing time (P is more than 0.05), and the patients have the highest healing proportion.
The ointment for removing slough and promoting tissue regeneration (patent of the invention) and the wound repair ointment (patent number: 202010510918.6) are respectively suitable for slough removal and tissue regeneration stages, and the ointment for removing slough and promoting tissue regeneration in our hospital cures over tens of thousands of acute and chronic wounds by using the skin-growing ointment, and particularly has better curative effects on various ulcers such as diabetic feet, lower limb venous ulcer, pressure sore and the like. A large number of clinical practices and researches show that the long-skin ointment can shorten the healing time of the wound and improve the healing rate of the wound. The combination of Chinese medicine external treatment methods such as fumigation, washing, wet dressing, binding and the like. Has obvious healing promoting effect on the lower limb venous ulcer, and has no potential safety hazard. The effective means and medicines for external treatment of the traditional Chinese medicine are integrated to be applied to the lower limb venous ulcer, and the clinical significance is great. The formed system clinical external treatment scheme has stronger scientificity and operability, is suitable for popularization, and provides clinical basis for the formulation of diagnosis and treatment guidelines for the venous ulcer of the lower limbs.
Test example 3
The ointment for removing slough and promoting granulation prepared in the embodiment 1 of the invention is used for clinical treatment tests of breast cancer patients and is compared with a control group to test the skin growth effect of the ointment of the invention.
The cases are as follows: one example of the patients with necrotic wound after radical treatment of breast cancer is a non-diabetic patient in the ninth national hospital affiliated to Shanghai university of transportation medical college, and the external application of the ointment for removing slough and promoting granulation is adopted. The wound surface is disinfected conventionally, covered with gauze after being applied with the ointment for removing slough and promoting granulation, and fixed by medical adhesive tape. The medicine is changed 1 time in 2 days, and the treatment course is 6 weeks. The routine blood, liver and kidney function and electrocardiogram before and after examination and treatment are all normal without toxic and side effects. Referring to fig. 5, fig. 5 is a diagram illustrating an example of the healing of necrotic wound after radical breast cancer surgery.
Referring to fig. 5, the experimental results show that, after applying the ointment for removing slough and promoting granulation of the present invention, the color of the wound surface after the breast cancer operation is significantly changed (purple dark → dark red → light red → ruddy), the granulation tissue rapidly grows and the epithelium crawls toward the center, and a small amount of yellowish exudate is still attached to the wound to maintain a moist environment. Therefore, the ointment for removing the necrotic tissue and promoting tissue regeneration can promote the rapid growth of granulation tissue, promote the rapid centripetal creeping of wound surface epithelium, shrink the wound surface, accelerate blood circulation, accelerate the metabolism of the wound surface and provide sufficient oxygen and nutrient substances for wound healing by improving local microcirculation and tissue nutrition.
In conclusion, the wound repair ointment can achieve the treatment purpose by being externally applied to the wound. Therefore, the clinical use of the wound repair ointment can promote the skin and flesh at the skin and flesh injury part to grow into skin and flesh, and can automatically repair damaged muscles and skin under the action of medicaments, thereby avoiding adverse effects of wound bacterial infection, tissue necrosis, permanent tissue defect and the like. Clinical practices prove that the wound repair ointment can promote the skin and meat injury of a human body to be repaired independently, and has magical curative effects on burns, scalds, gastric ulcer, gastrointestinal hemorrhage, non-healing of postoperative incision and diabetic gangrene.
In the foregoing embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and improvements can be made without departing from the principle of the present invention, and these modifications and improvements should also be considered as the protection scope of the present invention.
Claims (10)
1. The ointment for removing slough and promoting tissue regeneration is characterized by comprising the following raw materials in parts by weight: 10-50 parts of calamine, 70-130 parts of gypsum (calcined), 10-30 parts of nacre powder (calcined), 10-30 parts of gypsum rubrum powder (calcined), 70-130 parts of borax, 1-10 parts of borneol, 10-30 parts of centella asiatica and 770 parts of ointment matrix 640-.
2. The ointment for removing putrefaction and promoting tissue regeneration according to claim 1, wherein the ointment for removing putrefaction and promoting tissue regeneration comprises the following raw materials in parts by weight: 20-40 parts of calamine, 90-110 parts of calcined gypsum, 15-25 parts of calcined nacre powder, 15-25 parts of calcined gypsum powder, 90-110 parts of borax, 3-8 parts of borneol, 15-25 parts of centella asiatica and 730 parts of ointment matrix 680-.
3. The ointment for removing putrefaction and promoting tissue regeneration according to claim 2, wherein the ointment for removing putrefaction and promoting tissue regeneration comprises the following raw materials in parts by weight: 30 parts of calamine, 100 parts of gypsum (calcined), 20 parts of nacre powder (calcined), 20 parts of gypsum rubrum powder (calcined), 100 parts of borax, 5 parts of borneol, 20 parts of centella asiatica and 705 parts of ointment matrix.
4. The ointment for removing slough and promoting granulation according to claim 1, wherein the ointment matrix comprises the following raw materials in parts by weight: 50-150 parts of liquid paraffin and 800 parts of yellow vaseline.
5. The ointment for removing slough and promoting granulation according to claim 2 or 3, wherein the ointment matrix comprises the following raw materials in parts by weight: 80-120 parts of liquid paraffin and 500-700 parts of yellow vaseline; preferably, the ointment base comprises the following raw materials in parts by weight: 105 parts of liquid paraffin and 600 parts of yellow vaseline.
6. A method for preparing ointment for removing putrefaction and promoting granulation according to any one of claims 1-5, comprising the steps of:
preparing traditional Chinese medicine powder: pulverizing Galamina, Gypsum Fibrosum (calcined), Concha Margaritifera powder (calcined), Mirabilitum Crystallina powder (calcined), Borneolum Syntheticum, and herba Centellae into fine powder, sieving with 80-100 mesh sieve, and mixing to obtain mixed Chinese medicinal powder; crushing borax into fine powder, and sieving with a 80-100 mesh sieve to obtain borax powder;
preparing a matrix: melting the raw materials of the ointment matrix, stirring, and mixing to obtain matrix;
preparing an ointment: adding the mixed traditional Chinese medicine powder into the melted matrix, stirring until the temperature is reduced to 38-42 ℃, adding the borax powder, uniformly mixing, cooling, and subpackaging to obtain the ointment for removing the necrotic tissue and promoting tissue regeneration.
7. The method for preparing ointment for removing putrefaction and promoting granulation according to claim 6, wherein the stirring speed in the preparation matrix is 100-500 r/min.
8. The method for preparing ointment for removing putrefaction and promoting granulation according to claim 6, wherein the stirring speed is 100-500 r/min and the stirring time is 4-6 h.
9. The method for preparing the ointment for removing putrefaction and promoting tissue regeneration according to claim 6, wherein the ointment for removing putrefaction and promoting tissue regeneration comprises the following raw materials in parts by weight: 20-40 parts of calamine, 90-110 parts of gypsum (calcined), 15-25 parts of nacre powder (calcined), 15-25 parts of gypsum rubrum powder (calcined), 90-110 parts of borax, 3-8 parts of borneol, 15-25 parts of centella asiatica and 730 parts of ointment matrix 680-; the ointment base comprises 80-120 parts of liquid paraffin and 500-700 parts of yellow vaseline.
10. The application of the slough-removing and granulation-promoting ointment of any one of claims 1-5 in medicines for treating refractory wounds and promoting skin growth.
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| CN1935159A (en) * | 2006-09-18 | 2007-03-28 | 吴方忠 | Chinese medicine composition for treating burn, empyrosis and bodysurface ulcer and its preparing method |
| CN104997731A (en) * | 2015-07-21 | 2015-10-28 | 四川省中医药科学院 | Combination and composition-containing aerosol |
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| CN1935159A (en) * | 2006-09-18 | 2007-03-28 | 吴方忠 | Chinese medicine composition for treating burn, empyrosis and bodysurface ulcer and its preparing method |
| CN104997731A (en) * | 2015-07-21 | 2015-10-28 | 四川省中医药科学院 | Combination and composition-containing aerosol |
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Application publication date: 20220208 |