CN101703649A - Chinese patent medicament for treating bone traumatism and preparation process thereof - Google Patents
Chinese patent medicament for treating bone traumatism and preparation process thereof Download PDFInfo
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- CN101703649A CN101703649A CN200910024367A CN200910024367A CN101703649A CN 101703649 A CN101703649 A CN 101703649A CN 200910024367 A CN200910024367 A CN 200910024367A CN 200910024367 A CN200910024367 A CN 200910024367A CN 101703649 A CN101703649 A CN 101703649A
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Abstract
The invention relates to a Chinese patent medicament for treating bone traumatism, which comprises the following components of raw materials in part by weight: 30 to 70 parts of sanchi, 5 to 20 parts of dracaena cochinchinensis, 10 to 50 parts of myrrh, 20 to 50 parts of pyrite, 20 to 50 parts of fortune's drynaria rhizome, 10 to 50 parts of dahurian angelica root and 2 to 15 parts of borneol. The preparation method comprises the following steps: putting the sanchi, the fortune's drynaria rhizome and the dahurian angelica root together, extracting the raw materials with ethanol to prepare clear ointment, decocting the produced dregs of a decoction with water, and mixing the clear ointment with the decoction to prepare fine powder; mixing the dracaena cochinchinensis, the myrrh and the pyrite to prepare fine powder, mixing the two fine powders, and adding starch and ethanol into the fine powders to prepare soft materials; and granulating the soft materials in a granulator, and filling the granules into capsules. The Chinese patent medicament has the characteristics of quick cure of bone traumatism, stable curative effect, no toxic or side effect and low cost. The preparation process has the characteristics of simple preparation and convenient popularization.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly a kind of Chinese patent medicine and preparation technology thereof who treats bone injury.
Background technology
In daily life, traumatic injury, fracture and injury are a kind of common, frequently-occurring diseases, and its symptom is that the part is frustrated to decrease and caused fracture, hemorrhage hyperamization silt swelling, and sharp ache, heavy then function limitation, blood is transported and is obstructed.Wound is meant that extraneous factor acts on body and causes soft tissue injury persons such as local skin, meat, muscle.Set a broken bone adopts the maneuver Gypsum Fibrosum to reset mostly at present, also have the Chinese medicine of employing unguentum to apply ointment or plaster and treat, but these methods all can not alleviate the pain of patient in therapeutic process, and treatment cycle is also longer, and Therapeutic Method is also complicated.Therefore, single Therapeutic Method can not satisfy the needs of bone healing.
Summary of the invention
In order to overcome the shortcoming of above-mentioned prior art, the object of the present invention is to provide a kind of Chinese patent medicine and preparation technology thereof who treats bone injury, this medical instrument has the rapid healing bone disease, stable curative effect, have no side effect, cheap characteristics, it is simple that its preparation technology has preparation, the characteristics of being convenient to promote.
In order to achieve the above object, technical scheme of the present invention is achieved in that
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 2～15 parts of 30～70 parts of Radix Notoginseng, 5～20 parts of Sanguis Draxonis, 10～50 parts of Myrrhas, 20～50 parts of Pyritums, 20～50 parts of Rhizoma Drynariae, 10～50 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 2～15 parts of 30～70 parts of Radix Notoginseng, 5～20 parts of Sanguis Draxonis, 10～50 parts of Myrrhas, 20～50 parts of Pyritums, 20～50 parts of Rhizoma Drynariae, 10～50 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 30～70 portions of Radix Notoginseng, 20～50 parts of Rhizoma Drynariae and 10～50 parts of Radixs Angelicae Dahuricae put together add 3～8 times of amounts of drug weight 70～80% ethanol with 75-85 ℃ of reflux 1～3 hour, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 8～12 times of amounts of drug weight is poured out decoction liquor with 90～100 ℃ of decoctions 1～3 hour, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 60～80 ℃ are condensed into relative density and are determined as 1.35～1.38 thick paste at 60 ℃, 60～80 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 5～20 parts of Sanguis Draxonis, 10～50 parts of Myrrhas, 20～50 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; the 3rd step and the 4th standby fine powder that goes on foot and the starch mix homogeneously that accounts for fine powder total amount 1～10%; add 70～80% ethanol that account for mixed powder weight 15～20%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 60～80 ℃ in hothouse was dried by the fire 1～2 hour; cross 20 mesh sieve granulate; add 2～15 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Reuse Radix Notoginseng among the we and get its blood circulation promoting and blood stasis dispelling, the effect of reducing swelling and alleviating pain is we's a monarch drug, sweet, the little hardship of Radix Notoginseng, and temperature has hemostasis not stay the magical effect of the stasis of blood again, is used for traumatic injury, and being retarded by silt, it is particularly suitable to swell and ache; And Sanguis Draxonis, Myrrha, Pyritum, ministerial drug in the Rhizoma Drynariae side of being, Sanguis Draxonis is sweet, salty, flat, promoting blood circulation, removing blood stasis and relieving pain also has hemostasis not stay the characteristics of the stasis of blood, the Myrrha hardship, flat, promoting blood circulation and stopping pain, detumescence and promoting granulation is strengthened the monarch drug blood circulation promoting and blood stasis dispelling, the effect of reducing swelling and alleviating pain, the Pyritum suffering, flat, synthetism is cured the wound in the time of eliminating stasis to stop pain, the Rhizoma Drynariae hardship, temperature, promoting blood circulation and hemostasis, synthetism is continuous hinders, and this four flavor forms promoting blood flow and remove blood stasis and stop bleeding, the detumescence and promoting granulation analgesic therapy jointly with monarch drug, synthetism is cured the wound and is continued the effect of muscle: Radix Angelicae Dahuricae suffering in the side, temperature, get its detumescence and apocenosis, the analgesic effect can dissipate the routed person in injury, the evacuation of pus of routed person's energy, assistant helps the monarch and his subjects' detumescence and apocenosis, pain relieving, and strengthening therapeutic effect is we's adjuvant drug; Borneolum Syntheticum suffering, hardship are slightly cold, energy heat clearing away granulation promoting, and reducing swelling and alleviating pain, anticorrosion antipruritic, causing resuscitation with aromatic drugs draws the through sick institute of all medicines again, is messenger drug in the side.Full side is totally seven flavors, and the monarch collocation is proper, and the treatment bone injury can promoting blood circulation and detumescence, reunion of bone.
Characteristics of the present invention are, adopting does not have toxic and side effects and the Chinese crude drug of determined curative effect, thus have the rapid healing bone disease, stable curative effect, have no side effect, cheap characteristics, it is simple that its preparation technology has preparation, the characteristics of being convenient to promote.
The specific embodiment
Embodiment 1
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 6 parts of 60 parts of Radix Notoginseng, 15 parts of Sanguis Draxonis, 40 parts of Myrrhas, 30 parts of Pyritums, 30 parts of Rhizoma Drynariae, 40 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 6 parts of 60 parts of Radix Notoginseng, 15 parts of Sanguis Draxonis, 40 parts of Myrrhas, 30 parts of Pyritums, 30 parts of Rhizoma Drynariae, 40 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 60 portions of Radix Notoginseng, 30 parts of Rhizoma Drynariae, 40 parts of Radixs Angelicae Dahuricae put together add 7 times of amounts of drug weight 75% ethanol with 80 ℃ of reflux 2 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 10 times of amounts of drug weight is poured out decoction liquor with 100 ℃ of decoctions 1.5 hours, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 70 ℃ are condensed into relative density and are determined as 1.35 thick paste at 60 ℃, 80 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 15 parts of Sanguis Draxonis, 40 parts of Myrrhas, 30 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; with the standby fine powder and the starch mix homogeneously that account for fine powder total amount 6% of the 3rd step with the 4th step; add 75% ethanol that accounts for mixed powder weight 16%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 70 ℃ in hothouse was dried by the fire 1.5 hours; cross 20 mesh sieve granulate; add 6 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Embodiment 2
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 8 parts of 40 parts of Radix Notoginseng, 20 parts of Sanguis Draxonis, 30 parts of Myrrhas, 40 parts of Pyritums, 40 parts of Rhizoma Drynariae, 30 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 8 parts of 40 parts of Radix Notoginseng, 20 parts of Sanguis Draxonis, 30 parts of Myrrhas, 40 parts of Pyritums, 40 parts of Rhizoma Drynariae, 30 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 40 portions of Radix Notoginseng, 40 parts of Rhizoma Drynariae, 30 parts of Radixs Angelicae Dahuricae put together add 6 times of amounts of drug weight 80% ethanol with 75 ℃ of reflux 2.5 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 12 times of amounts of drug weight is poured out decoction liquor with 95 ℃ of decoctions 2 hours, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 75 ℃ are condensed into relative density and are determined as 1.38 thick paste at 60 ℃, 80 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 20 parts of Sanguis Draxonis, 30 parts of Myrrhas, 40 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; with the standby fine powder and the starch mix homogeneously that account for fine powder total amount 5% of the 3rd step with the 4th step; add 80% ethanol that accounts for mixed powder weight 18%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 80 ℃ in hothouse was dried by the fire 1 hour; cross 20 mesh sieve granulate; add 8 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Embodiment 3
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 12 parts of 30 parts of Radix Notoginseng, 5 parts of Sanguis Draxonis, 50 parts of Myrrhas, 20 parts of Pyritums, 50 parts of Rhizoma Drynariae, 20 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 12 parts of 30 parts of Radix Notoginseng, 5 parts of Sanguis Draxonis, 50 parts of Myrrhas, 20 parts of Pyritums, 50 parts of Rhizoma Drynariae, 20 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 30 portions of Radix Notoginseng, 50 parts of Rhizoma Drynariae, 20 parts of Radixs Angelicae Dahuricae put together add 8 times of amounts of drug weight 70% ethanol with 80 ℃ of reflux 1.5 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 10 times of amounts of drug weight is poured out decoction liquor with 98 ℃ of decoctions 2 hours, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 65 ℃ are condensed into relative density and are determined as 1.36 thick paste at 60 ℃, 70 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 5 parts of Sanguis Draxonis, 50 parts of Myrrhas, 20 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; with the standby fine powder and the starch mix homogeneously that account for fine powder total amount 8% of the 3rd step with the 4th step; add 80% ethanol that accounts for mixed powder weight 15%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 75 ℃ in hothouse was dried by the fire 1 hour; cross 20 mesh sieve granulate; add 12 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Embodiment 4
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 4 parts of 70 parts of Radix Notoginseng, 10 parts of Sanguis Draxonis, 20 parts of Myrrhas, 50 parts of Pyritums, 20 parts of Rhizoma Drynariae, 30 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 4 parts of 70 parts of Radix Notoginseng, 10 parts of Sanguis Draxonis, 20 parts of Myrrhas, 50 parts of Pyritums, 20 parts of Rhizoma Drynariae, 30 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 70 portions of Radix Notoginseng, 20 parts of Rhizoma Drynariae, 30 parts of Radixs Angelicae Dahuricae put together add 6 times of amounts of drug weight 75% ethanol with 85 ℃ of reflux 2 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 12 times of amounts of drug weight is poured out decoction liquor with 100 ℃ of decoctions 2 hours, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 80 ℃ are condensed into relative density and are determined as 1.37 thick paste at 60 ℃, 80 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 10 parts of Sanguis Draxonis, 20 parts of Myrrhas, 50 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; with the standby fine powder and the starch mix homogeneously that account for fine powder total amount 10% of the 3rd step with the 4th step; add 70% ethanol that accounts for mixed powder weight 20%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 65 ℃ in hothouse was dried by the fire 1.5 hours; cross 20 mesh sieve granulate; add 4 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Embodiment 5
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 15 parts of 50 parts of Radix Notoginseng, 15 parts of Sanguis Draxonis, 10 parts of Myrrhas, 50 parts of Pyritums, 50 parts of Rhizoma Drynariae, 10 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 15 parts of 50 parts of Radix Notoginseng, 15 parts of Sanguis Draxonis, 10 parts of Myrrhas, 50 parts of Pyritums, 50 parts of Rhizoma Drynariae, 10 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 50 portions of Radix Notoginseng, 50 parts of Rhizoma Drynariae, 10 parts of Radixs Angelicae Dahuricae put together add 8 times of amounts of drug weight 75% ethanol with 70 ℃ of reflux 1 hour, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the aborning medicinal residues of the first step is added 8 times of amounts of drug weight decocted 3 hours with 90 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 60 ℃ are condensed into relative density and are determined as 1.35 thick paste at 60 ℃, 75 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 15 parts of Sanguis Draxonis, 10 parts of Myrrhas, 50 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; with the standby fine powder and the starch mix homogeneously that account for fine powder total amount 2% of the 3rd step with the 4th step; add 80% ethanol that accounts for mixed powder weight 15%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 60 ℃ in hothouse was dried by the fire 2 hours; cross 20 mesh sieve granulate; add 15 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Embodiment 6
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 10 parts of 45 parts of Radix Notoginseng, 12 parts of Sanguis Draxonis, 25 parts of Myrrhas, 45 parts of Pyritums, 20 parts of Rhizoma Drynariae, 50 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 10 parts of 45 parts of Radix Notoginseng, 12 parts of Sanguis Draxonis, 25 parts of Myrrhas, 45 parts of Pyritums, 20 parts of Rhizoma Drynariae, 50 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 45 portions of Radix Notoginseng, 20 parts of Rhizoma Drynariae, 50 parts of Radixs Angelicae Dahuricae put together add 7 times of amounts of drug weight 75% ethanol with 80 ℃ of reflux 1.5 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 10 times of amounts of drug weight is poured out decoction liquor with 100 ℃ of decoctions 2.5 hours, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 80 ℃ are condensed into relative density and are determined as 1.38 thick paste at 60 ℃, 60 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 12 parts of Sanguis Draxonis, 25 parts of Myrrhas, 45 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; with the standby fine powder and the starch mix homogeneously that account for fine powder total amount 4% of the 3rd step with the 4th step; add 75% ethanol that accounts for mixed powder weight 20%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 65 ℃ in hothouse was dried by the fire 1.5 hours; cross 20 mesh sieve granulate; add 10 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Embodiment 7
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 2 parts of 55 parts of Radix Notoginseng, 8 parts of Sanguis Draxonis, 35 parts of Myrrhas, 40 parts of Pyritums, 25 parts of Rhizoma Drynariae, 45 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 2 parts of 55 parts of Radix Notoginseng, 8 parts of Sanguis Draxonis, 35 parts of Myrrhas, 40 parts of Pyritums, 25 parts of Rhizoma Drynariae, 45 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 55 portions of Radix Notoginseng, 25 parts of Rhizoma Drynariae, 45 parts of Radixs Angelicae Dahuricae put together add 6 times of amounts of drug weight 80% ethanol with 85 ℃ of reflux 2 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 10 times of amounts of drug weight is poured out decoction liquor with 95 ℃ of decoctions 2 hours, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 65 ℃ are condensed into relative density and are determined as 1.36 thick paste at 60 ℃, 80 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 8 parts of Sanguis Draxonis, 35 parts of Myrrhas, 40 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; with the standby fine powder and the starch mix homogeneously that account for fine powder total amount 6% of the 3rd step with the 4th step; add 75% ethanol that accounts for mixed powder weight 16%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 70 ℃ in hothouse was dried by the fire 1.5 hours; cross 20 mesh sieve granulate; add 2 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Embodiment 8
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 8 parts of 65 parts of Radix Notoginseng, 10 parts of Sanguis Draxonis, 20 parts of Myrrhas, 50 parts of Pyritums, 30 parts of Rhizoma Drynariae, 30 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 8 parts of 65 parts of Radix Notoginseng, 10 parts of Sanguis Draxonis, 20 parts of Myrrhas, 50 parts of Pyritums, 30 parts of Rhizoma Drynariae, 30 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 65 portions of Radix Notoginseng, 30 parts of Rhizoma Drynariae, 30 parts of Radixs Angelicae Dahuricae put together add 6 times of amounts of drug weight 80% ethanol with 85 ℃ of reflux 2.5 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 10 times of amounts of drug weight is poured out decoction liquor with 90 ℃ of decoctions 1.5 hours, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 70 ℃ are condensed into relative density and are determined as 1.37 thick paste at 60 ℃, 75 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 10 parts of Sanguis Draxonis, 20 parts of Myrrhas, 50 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; with the standby fine powder and the starch mix homogeneously that account for fine powder total amount 8% of the 3rd step with the 4th step; add 70% ethanol that accounts for mixed powder weight 18%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 80 ℃ in hothouse was dried by the fire 1 hour; cross 20 mesh sieve granulate; add 8 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Embodiment 9
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 10 parts of 35 parts of Radix Notoginseng, 20 parts of Sanguis Draxonis, 40 parts of Myrrhas, 30 parts of Pyritums, 45 parts of Rhizoma Drynariae, 35 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 10 parts of 35 parts of Radix Notoginseng, 20 parts of Sanguis Draxonis, 40 parts of Myrrhas, 30 parts of Pyritums, 45 parts of Rhizoma Drynariae, 35 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 35 portions of Radix Notoginseng, 45 parts of Rhizoma Drynariae, 35 parts of Radixs Angelicae Dahuricae put together add 6 times of amounts of drug weight 75% ethanol with 75 ℃ of reflux 2 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 10 times of amounts of drug weight is poured out decoction liquor with 95 ℃ of decoctions 2 hours, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 75 ℃ are condensed into relative density and are determined as 1.38 thick paste at 60 ℃, 70 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 20 parts of Sanguis Draxonis, 40 parts of Myrrhas, 30 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; with the standby fine powder and the starch mix homogeneously that account for fine powder total amount 6% of the 3rd step with the 4th step; add 80% ethanol that accounts for mixed powder weight 15%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 60 ℃ in hothouse was dried by the fire 1.5 hours; cross 20 mesh sieve granulate; add 10 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Embodiment 10
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent comprises: 6 parts of 50 parts of Radix Notoginseng, 10 parts of Sanguis Draxonis, 40 parts of Myrrhas, 30 parts of Pyritums, 30 parts of Rhizoma Drynariae, 50 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of Chinese patent medicine for the treatment of bone injury, its raw material weight constituent is: 6 parts of 50 parts of Radix Notoginseng, 10 parts of Sanguis Draxonis, 40 parts of Myrrhas, 30 parts of Pyritums, 30 parts of Rhizoma Drynariae, 50 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
A kind of preparation technology who treats the Chinese patent medicine of bone injury may further comprise the steps:
The first step, 50 portions of Radix Notoginseng, 30 parts of Rhizoma Drynariae, 50 parts of Radixs Angelicae Dahuricae put together add 5 times of amounts of drug weight 80% ethanol with 80 ℃ of reflux 3 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 12 times of amounts of drug weight is poured out decoction liquor with 100 ℃ of decoctions 1 hour, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 80 ℃ are condensed into relative density and are determined as 1.38 thick paste at 60 ℃, 65 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 10 parts of Sanguis Draxonis, 40 parts of Myrrhas, 30 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; with the standby fine powder and the starch mix homogeneously that account for fine powder total amount 4% of the 3rd step with the 4th step; add 70% ethanol that accounts for mixed powder weight 17%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 75 ℃ in hothouse was dried by the fire 2 hours; cross 20 mesh sieve granulate; add 6 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
Clinical experiment
Case one: Lee so-and-so, man, 38 years old, Xi'an teacher.Wounded by automobile when sitting pedicab and be hospitalized for treatment unbearably to thoracic dorsal severe pain, the left chest rib sassafras sound of having a medical check-up is obvious, thoracic dorsal large area skin soft tissue contusion hematoma.Taking 1,3～7 days chest and back lacerations of skin of embodiment different time successively heals.
Case two: Liu so-and-so, woman, 28 years old, Xi'an businessman.Hit by automobile in the time of by motorcycle and get injured by a fall abdominal part and be hospitalized for treatment, have a medical check-up: sacral fracture, right fracture of pubis, left abdominal part, gluteus sarcocyte congestive edema.Through taking embodiment 2, laceration of skin healing in 3～7 days was checked after January, and fracture has callus formation.
Case three: Zhao so-and-so, man, 14 years old.The student.Hit by truck during because of bike riding and get injured by a fall abdominal part and be admitted to institute treatment.Have a medical check-up: right abdominal part ecchymoma and epidermis are wiped and are split, and right elbow, hall, lower limb, the equal skin soft tissue of knee joint are wiped the laceration hematoma.Take the photograph the X-ray film report: ILR fracture and pubic symphysis separate.Through taking embodiment 3, laceration of skin healing in 3～7 days is checked existing callus formation of fracture of ilium and pubic symphysis separation and is restored after January.
Case four: Chen, man, 28 years old, workman.Fall to hinder because of traffic accident and cause right wrist swelling pain limitation of activity 3 hours.Have a medical check-up: each wrist swelling tenderness, the right wrist joint function obstacle of Silver-fork deformity.Take the photograph the X-ray film report: right radius far-end fracture.Fix through the maneuver clamping plate that reset, take embodiment 4 simultaneously.Each wrist swelling pain disappears during one week back further consultation, the right radius far-end fracture heading line off of check after January, and the seriality callus is passed through.
Case five: grandson so-and-so, woman, 56 years old, retired worker.Because of neighbourhood's dispute and people disagree, caused chest left side pain then by people's left chest of wounding, the pain increased during cough.Through taking the photograph the X-ray film report: cardiopulmonary, chest rib there is no unusually.Substantially disappear through taking embodiment 5, one week back patient's pain, own activity freely.
Case six: the field so-and-so, woman, 32 years old, civil servant.Careless traumatic injury during because of out on tours, left elbow joint swells and ache, and can not stretch to bend and be hospitalized for treatment.Have a medical check-up: left elbow joint swelling, tenderness is obvious, the elbow joint limitation of activity, the joint skin soft tissue is wiped the laceration hematoma.Take the photograph the X-ray film report: the dislocation of left elbow joint fracture.Fix through the maneuver clamping plate that reset, take simultaneously embodiment after 6,3 days the patient promptly feel pain and obviously alleviate, swelling is obviously disappeared, blood stasis disappears gradually after 7 days.Check after January, left elbow joint fracture has callus formation.
Case seven: Zhang, man, 62 years old, retired college professor.Careless traumatic injury is slipped during because of morning exercises, wrist swelling, stiff being hospitalized for treatment.Have a medical check-up: the left finesse arthroncus, tenderness is obvious, carpal joint limitation of activity, the visible blood stasis of joint.Take the photograph the X-ray film report: left finesse dislocation, comminuted fracture of distal radius.Fix through the maneuver clamping plate that reset, take simultaneously embodiment after 7,7 days the patient promptly feel pain and obviously alleviate, swelling is obviously disappeared.Check after January, left carpal joint fracture of radius place has callus formation.
Case eight: Korea Spro so-and-so, man, 19 years old, soldier.Careless traumatic injury during because of military training, left knee joint swells and ache, the unable to walk treatment of walking to be admitted to hospital.Have a medical check-up: left knee joint swelling, tenderness is obvious, knee joint limitation of activity, local visible ecchymosis.Taking the photograph the X report from a liner accuses: left knee joint is not seen fracture.Clinical diagnosis: left knee joint acute sprain.Take embodiment after 8,3 days the patient promptly feel pain and obviously alleviate, swelling is obviously disappeared, a week back pain and swelling complete obiteration, the patient walks freely.
Case nine: close so-and-so, the man, 17 years old, the student. fall accidentally when playing ball, right ankle joint swells and ache, limitation of activity is admitted to hospital treatment. and have a medical check-up: right ankle also saves swelling, tenderness obviously, with before the waihuaiji down for very, the ankle joint limitation of activity, can not land, local visible large stretch of blood stasis, vertically percussion pain. take the photograph the X-ray film report: right ankle joint dislocation and fracture. fix through the maneuver clamping plate that reset, take embodiment 9 simultaneously, the patient promptly feels pain and obviously alleviates after 3 days, swelling is obviously disappeared, and blood stasis fades and moves back .1 and check after the month, and right ankle joint fracture place has callus formation.
Case ten: surplus so-and-so, woman, 52 years old, workman.Because of the working duration of work is caused thoracic dorsal severe pain to be hospitalized for treatment unbearably by the lathe bump accidentally, the right chest rib sassafras sound of having a medical check-up is obvious, thoracic dorsal large area skin soft tissue contusion hematoma.Taking the photograph the X report from a liner accuses: right the 2nd～6 posterior rib fracture.Take 10,3～7 days chest and back lacerations of skin of embodiment different time and successively heal, check after January, right fracture of rib increase in density has a small amount of growth of spur.
Animal acute toxicity test and clinical observation
One, embodiment 1 animal acute toxicity test
1 test objective: observe the reaction of embodiment 1 animal acute toxicity, measure animal median lethal dose(LD 50) or maximum tolerated dose.
2 animals: ICR strain mice, male and female dual-purpose, body weight 20 ± 2g.Provide by Xi'an Jiaotong University Medical College's Experimental Animal Center.The quality certification number: the moving card of Shan doctor word 08-004.
3 route of administration: gastric infusion.
4 test ambient temperature, humidity: 23～24 ℃ of room temperatures, relative humidity 68～71%.
5 methods
5.1 trial test: the geometric progression series dosage disposable gastric infusion that divides into groups was observed 7 days, did not find minimum complete dead dosage.So formal test changes the survey maximum tolerated dose.
5.2 formal experiment: get 20 of ICR strain mices, male and female half and half are weighed and are used the picric acid marker number.Pour out embodiment 1 capsule medicated powder, being made into maximum concentration with distilled water is 23.8% suspension, and mice state on an empty stomach press 0.4mL/10g body weight filling stomach down, irritates stomach the same day altogether 3 times, interval 4h, after the administration, mice is put into animal feeding room, conventional feed is freely drunk water, and observes continuously 15.
5 results: test mice does not have death.Do not observe other physiology and dystropy yet.The prompting mice can tolerate the embodiment 1 capsule medicated powder gastric infusion of maximum concentration, heap(ed) capacity.
6 brief summaries: embodiment, 1 capsule mice maximum tolerated dose is the 28.56g/kg body weight, is equivalent to clinical people and intends with dosage (253.9～317.3 times (body weight for humans is by 60kg) of 5.4～6.75g/d).
Two, embodiment 1 capsule clinical observation on the therapeutic effect
1 is subjected to reagent thing: embodiment 1 capsule, 450mg/ grain.
2 test objectives: observe curative effect and dosage (4～5/time of client's recommended doses, 3 times/day) that it promotes union of fracture, observe clinical drug safety simultaneously.
3 EXPERIMENTAL DESIGN
3.1 contrast medicine: bone setting tablet.
3.2 case choice criteria
3.2.1 fracture diagnostic criteria: (1) diagnosis: 1. medical history statement: direct, indirect trauma history is arranged; 2. General Symptoms: uncomplicated simple fracture, General Symptoms is not obvious or not serious; 3. local symptom: pain and tenderness, local swelling, dysfunction, deformity, abnormal movement, bone crunch; 4. X ray examination: the diagnosis that can clearly fracture, can confirm localized variation such as classification of fracture, displacement mode, fracture end form, and get rid of pathologisch Bruch.(2) classification: 1. fracture and injury character: closure or opening; 2. fracture and injury type: horizontal shape, oblique, comminuted, spiral type etc.; 3. fracture and injury position: upper limb, lower limb, tibia, radius etc.; 4. fracture and injury degree: displacement, overlapping, separation etc.
The case standard 3.2.2 participate in the experiment: (1) includes the case standard in: 1. meet the fracture diagnostic criteria; 2. 18～65 years old age; 3. 3 weeks are with interior freshness extremity fracture. and (2) get rid of case standard (comprising inapplicable or the rejecting standard): 1. by the pathologisch Bruch due to the factors such as tumor; 2. three spend open fractures, concurrent infection or serious visceral organ injury fracture; 3. gestation or women breast-feeding their children; 4. to this medicine allergy sufferers; 5. be associated with serious primary disease such as cardiovascular, lung, liver, kidney, brain, hemopoietic and hormonal system; 6. take with this medicine function and cure mainly akin medicine and the influential medicine of union of fracture; 7. fracture does not reach the functional reduction standard, effectively fixing person after resetting; 8. I freely accept embodiment 1 capsule for treating voluntarily, but promise to undertake duration of test except that short-term with antimicrobial drug, the analgesic without other medicines, as drug for invigorating blood circulation and eliminating stasis, repellent etc.
3.3 observation index
3.3.1 safety is observed: (1) general health check-up project; (2) blood, urine routine test; (3) heart, liver, kidney, function effect.
3.3.2 observation of curative effect: (1) promotes the union of fracture situation; (2) detumescence situation; (3) pain relieving situation.
3.4 medication: 5/time of (1) test group: embodiment 1 capsules, 3 times/day, oral; (2) matched group: bone setting tablet, 4 slices/time, 3 times/day, oral.
3.5 the course of treatment: 1 week was 1 course of treatment, took the circumstances into consideration to observe 2～12 courses of treatment according to fracture site.
3.6 curative effect determinate standard
3.6.1 union of fracture standard: (1) clinical union of bone standard: 1. local no tenderness, there is not vertical percussion pain; 2. local no abnormal activity; 3. the X skiagram shows that fracture line is fuzzy, has the seriality callus to pass through fracture line; 4. removing under the external fixation situation, upper limb can put down and be lifted the 1kg weight and reach 1min, and lower limb can capable on foot continuously 3min, and is no less than 30 and goes on foot.Observed for 2 weeks continuously, fracture is indeformable, is the clinical healing phase in the 1st day that then observes.2., 4. two functional examinations must be cautiously, not deform or refracture is a principle.(2) Gu Zhe bony union standard: the standard conditions that 1. possess clinical union of bone; 2. the X skiagram shows that bone trabecula passes through fracture line.(3) observe fracture site clinical healing time reference value and average time: chi fracture of radial shaft: 6～8 weeks, average 7 weeks; Humeral shaft fracture: 4～8 weeks, average 6 weeks; Fracture of shaft of femur: 8～12 weeks, average 10 weeks; Fracture of shaft of tibia: 7～10 weeks, average 9 weeks.
3.6.2 the therapeutic evaluation standard: healing time is averaged.The similar healing time of clinical application time ratio more than 1/3, reaches clinical healing standard person and is chosen as excellent in advance; The similar healing time of clinical application time ratio shifts to an earlier date 1/4～1/3, reaches clinical healing standard person and is chosen as very; The similar healing time of clinical application time ratio in advance 1/5～1/4, reaching that clinical healing standard person is chosen as can; It is poor that identical person with similar healing time of clinical application time is chosen as.
3.6.3 record standards of grading: (1) X line growth of spur situation of change scoring: 1. do not have growth of spur, fracture line clear (0 minute); 2. a small amount of inside and outside callus formation, density light (2 minutes); 3. more inside and outside callus formation, density slightly high (4 minutes); 4. callus forms in a large number, fracture line disappearance (6 minutes).(2) pain: 1. painless (0 minute); 2. endurable pain does not require and takes analgesic, and the interference-free VAS that sleeps is 1～3 (2 minutes); 3. pain is obvious, and is moving then increase the weight of to be impatient at, and need take a small amount of analgesic, and sleep is disturbed, and VAS is 3～7 (4 minutes); 4. sharp ache is difficult to stand, and need take analgesic, and sleep is seriously disturbed, and VAS is 7～10 (6 minutes).(3) swelling: 1. fracture does not have swelling (0 minute); 2. slightly swelling of tissue, skin texture is slightly shallow, and the planar limbs Zhou Jing that fractures is greater than strong side 0.5～1cm (2 minutes); 3. swelling is obvious, and dermatoglyph obviously shoals, and the planar limbs Zhou Jing that fractures is greater than strong side 1.1～2.0cm (4 minutes); 4. serious swelling, epidermis is shinny, and dermatoglyph disappears, and the planar limbs Zhou Jing that fractures is greater than strong more than the side 2.1cm (6 minutes).
3.7 statistical method: measurement data is with t check, enumeration data χ
2Check.
4 case data: choose case totally 76 examples that meet clinical inclusion criteria. test group 40 examples, male 29 examples, women 11 examples, 19～54 years old age, average 36.2 years old; Humeral shaft fracture 12 examples, fracture of shaft of femur 13 examples, fracture of tibia and fibula 15 examples; Transverse fracture 13 examples, inclined-plane 17 examples of fracturing, spiral fracture 6 examples, syntripsis 4 examples. matched group 36 examples, male 28 examples, women 8 examples, 18～57 years old age, average 39.5 years old; Humeral shaft fracture 10 examples, fracture of shaft of femur 13 examples, fracture of tibia and fibula 13 examples; Transverse fracture 11 examples, inclined-plane 18 examples of fracturing, spiral fracture 4 examples, syntripsis 3 routine .2 group sexes, age, situation no difference of science of statistics such as clinical have comparability.
5 result of the tests
5.1 safety is observed: be subjected to the reagent thing to general health check-up project, blood, routine urinalysis, vitals functions such as the heart, liver, kidney not influential (physical resource slightly).
5.2 overall clinical efficacy: though embodiment 1 capsule promotes union of fracture total effective rate and matched group comparison no difference of science of statistics (P＞0.05 sees Table 1), embodiment 1 Capsules group total effective rate height.
Table 1 is subjected to the comparison of examination group and matched group clinical efficacy
Compare * P＞0.05 with matched group
5.3 the fracture clinical cure time: test group and matched group clinical cure time ratio are than no difference of science of statistics (P＞0.05), but the average clinical healing time of embodiment 1 Capsules group is short.Prompting embodiment 1 capsule onset is faster than bone setting tablet.See Table 2.
The table 2 fracture clinical cure time (x ± s)
Compare * P＞0.05 with matched group
5.4X line growth of spur scoring: as shown in table 3, test group and the scoring of matched group growth of spur be equal 〉=and 2 minutes.Show that embodiment 1 capsule promotes the union of fracture curative effect certainly.
Table 3 the 4th all growth of spur scorings (routine number)
Compare * P＞0.05 with matched group
5.5 pain and swelling evaluation: test group and matched group pain and local swelling mitigation are also approaching, but the effect of embodiment 1 capsule alleviation swelling is stronger.Add up pain evaluation in the 7th day and swelling evaluation in the 14th day sees Table 4.
Table 4 pain evaluation in the 7th day and swelling evaluation (routine number) in the 14th day
Compare * P＞0.05 with matched group
6 conclusion (of pressure testing)s: embodiment, 1 capsule promotes the union of fracture curative effect certainly, symptoms such as while energy alleviating pain, swelling, and general curative effect is better than bone setting tablet.
Claims (10)
1. Chinese patent medicine for the treatment of bone injury, it is characterized in that its raw material weight constituent comprises: 2～15 parts of 30～70 parts of Radix Notoginseng, 5～20 parts of Sanguis Draxonis, 10～50 parts of Myrrhas, 20～50 parts of Pyritums, 20～50 parts of Rhizoma Drynariae, 10～50 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
2. a kind of Chinese patent medicine for the treatment of bone injury according to claim 1, it is characterized in that its raw material weight constituent is: 2～15 parts of 30～70 parts of Radix Notoginseng, 5～20 parts of Sanguis Draxonis, 10～50 parts of Myrrhas, 20～50 parts of Pyritums, 20～50 parts of Rhizoma Drynariae, 10～50 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
3. a kind of Chinese patent medicine for the treatment of bone injury according to claim 2 is characterized in that, its raw material weight constituent is: 6 parts of 60 parts of Radix Notoginseng, 15 parts of Sanguis Draxonis, 40 parts of Myrrhas, 30 parts of Pyritums, 30 parts of Rhizoma Drynariae, 40 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
4. a kind of Chinese patent medicine for the treatment of bone injury according to claim 2 is characterized in that, its raw material weight constituent is: 8 parts of 40 parts of Radix Notoginseng, 20 parts of Sanguis Draxonis, 30 parts of Myrrhas, 40 parts of Pyritums, 40 parts of Rhizoma Drynariae, 30 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
5. a kind of Chinese patent medicine for the treatment of bone injury according to claim 2 is characterized in that, its raw material weight constituent is: 12 parts of 30 parts of Radix Notoginseng, 5 parts of Sanguis Draxonis, 50 parts of Myrrhas, 20 parts of Pyritums, 50 parts of Rhizoma Drynariae, 20 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
6. a kind of Chinese patent medicine for the treatment of bone injury according to claim 2 is characterized in that, its raw material weight constituent is: 4 parts of 70 parts of Radix Notoginseng, 10 parts of Sanguis Draxonis, 20 parts of Myrrhas, 50 parts of Pyritums, 20 parts of Rhizoma Drynariae, 30 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
7. a kind of Chinese patent medicine for the treatment of bone injury according to claim 2 is characterized in that, its raw material weight constituent is: 15 parts of 50 parts of Radix Notoginseng, 15 parts of Sanguis Draxonis, 10 parts of Myrrhas, 50 parts of Pyritums, 50 parts of Rhizoma Drynariae, 10 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
8. a kind of Chinese patent medicine for the treatment of bone injury according to claim 2 is characterized in that, its raw material weight constituent is: 10 parts of 45 parts of Radix Notoginseng, 12 parts of Sanguis Draxonis, 25 parts of Myrrhas, 45 parts of Pyritums, 20 parts of Rhizoma Drynariae, 50 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
9. a kind of Chinese patent medicine for the treatment of bone injury according to claim 2 is characterized in that, its raw material weight constituent is: 2 parts of 55 parts of Radix Notoginseng, 8 parts of Sanguis Draxonis, 35 parts of Myrrhas, 40 parts of Pyritums, 25 parts of Rhizoma Drynariae, 45 parts of the Radixs Angelicae Dahuricae and Borneolum Syntheticums.
10. a preparation technology who treats the Chinese patent medicine of bone injury is characterized in that, may further comprise the steps:
The first step, 30～70 portions of Radix Notoginseng, 20～50 parts of Rhizoma Drynariae and 10～50 parts of Radixs Angelicae Dahuricae put together add 3～8 times of amounts of drug weight 70～80% ethanol with 75-85 ℃ of reflux 1～3 hour, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, it is standby to make clear paste
In second step, the water that the medicinal residues that the first step is produced add 8～12 times of amounts of drug weight is poured out decoction liquor with 90～100 ℃ of decoctions 1～3 hour, decocts for the second time with the same terms again, pours out decoction liquor, merges the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
In the 3rd step, the clear paste that the first step is made mixes with the filtrate in second step, and 60～80 ℃ are condensed into relative density and are determined as 1.35～1.38 thick paste at 60 ℃, 60～80 ℃ of dryings, and pulverizing, mistake 80 mesh sieves, mix homogeneously, it is standby to make fine powder,
The 4th step, 5～20 parts of Sanguis Draxonis, 10～50 parts of Myrrhas, 20～50 parts of Pyritums are mixed pulverizing, cross 80 mesh sieves, it is standby to make fine powder,
The 5th step; the 3rd step and the 4th standby fine powder that goes on foot and the starch mix homogeneously that accounts for fine powder total amount 1～10%; add 70～80% ethanol that account for mixed powder weight 15～20%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 60～80 ℃ in hothouse was dried by the fire 1～2 hour; cross 20 mesh sieve granulate; add 2～15 parts of Borneolum Syntheticum mix homogeneously, be filled to capsule, promptly.
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| CN112206272A (en) * | 2020-11-06 | 2021-01-12 | 李田来 | External cold compress gel for closed soft tissue |
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| CN101422552B (en) * | 2007-10-29 | 2013-04-24 | 郭继焕 | Traditional Chinese medicine black plaster capable of activating blood circulation to dissipate blood stasis, joining bone and alleviating pain and preparation technique thereof |
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| CN102188527B (en) * | 2011-04-22 | 2013-03-06 | 李何庭 | Chinese medicinal skin externally-stuck bone setting medicament |
| CN112206272A (en) * | 2020-11-06 | 2021-01-12 | 李田来 | External cold compress gel for closed soft tissue |
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