CN102670895A - Chinese medicinal composition for treating joint traumatic synovitis and preparation method thereof - Google Patents
Chinese medicinal composition for treating joint traumatic synovitis and preparation method thereof Download PDFInfo
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- CN102670895A CN102670895A CN2011100585628A CN201110058562A CN102670895A CN 102670895 A CN102670895 A CN 102670895A CN 2011100585628 A CN2011100585628 A CN 2011100585628A CN 201110058562 A CN201110058562 A CN 201110058562A CN 102670895 A CN102670895 A CN 102670895A
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Abstract
The invention discloses an externally-applied Chinese medicinal composition for treating joint traumatic synovitis. The Chinese medicinal composition is prepared from the following bulk pharmaceuticals in parts by weight: 30-50 parts of rosin, 12-20 parts of frankincense, 12-20 parts of myrrh, 30-50 parts of dahurian angelica root, 30-50 parts of rhubarb, 18-30 parts of mirabilite, 3-5 parts of dragon's blood and 3-5 parts of borneol. The Chinese medicinal composition has the effects of promoting blood circulation, removing obstruction in channels, reducing swelling and alleviating pain, and can directly act on a joint suffering from synovitis for eliminating local inflammations. Moreover, the invention further discloses a preparation method of the Chinese medicinal composition.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of treating articular trauma property synovitis, in addition, the invention still further relates to the method for preparing of this Chinese medicine composition.
Background technology
Articular trauma property synovitis is a kind of surgical common disease, is the synovial membrane aseptic inflammation reaction that causes after the joint injury.Obvious trauma history such as acute synovitis has collision more, sprain, acute stage skin temperature increase.Chronic synovitis is generally controlled by acute mistake and is transformed, and strain or arthralgia medical history are arranged, and arthrocentesiS liquid is faint yellow more limpid transudate, sees at most with knee joint.Primary disease mainly shows as local joint swelling and pain, local tenderness and limitation of movement.At present doctor trained in Western medicine adopts methods such as oral or closed injection such as hormone, nonsteroidal anti-inflammatory and tapping, operation to treat more.Often need repeatedly can fully recover after the tapping, the course of treatment is long, and late result is not good, is prone to recurrence, and side effect is big, the patient suffering.External treatment of Chinese medicine, good effect, painful few, be one of important method of present clinical treatment primary disease.Articular trauma property synovitis, the traditional Chinese medical science belong to " arthromyodynia " more, morbidity with dampen and strain relevantly, pathogenesis is that venation is impaired, QI-blood circulation is not smooth, the wet meridians that block of water.Chinese medicine reducing swelling and alleviating pain effect is obvious, effective percentage is high, side effect is little.Also need inquire into strong operability and obvious results medicine and method at present, to optimize the scheme of treatment articular trauma property synovitis.
Summary of the invention
Technical problem to be solved by this invention is to propose a kind of treatment articular trauma property synovitis compositions, and proposes the method for preparing of this Chinese medicine composition.This Chinese medicine composition function promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain; Can directly act on the joint synovitis disease position, improve local blood circulation, the dissipation hydrops.
The present invention for the technical scheme that solves its technical problem and adopt is: a kind of Chinese medicine composition of treating articular trauma property synovitis is the medicament that is prepared from following raw medicaments in portion by weight: Colophonium 30-50 part; Olibanum 12-20 part; Myrrha 12-20 part; Radix Angelicae Dahuricae 30-50 part; Radix Et Rhizoma Rhei 30-50 part; Natrii Sulfas 18-30 part; Sanguis Draxonis 3-5 part; Borneolum Syntheticum 3-5 part.
Preferably, in the Chinese medicine composition of aforementioned therapies articular trauma property synovitis of the present invention, the weight portion of each crude drug is respectively: 10 parts of Colophonium; 4 parts of Olibanums; 4 parts of Myrrhas; 10 parts of the Radixs Angelicae Dahuricae; 10 parts of Radix Et Rhizoma Rhei; 6 parts in Natrii Sulfas; 1 part of Sanguis Draxonis; 1 part of Borneolum Syntheticum.
Preferably, the dosage form of the Chinese medicine composition of aforementioned therapies articular trauma property synovitis of the present invention is a powder.
The method for preparing of the Chinese medicine composition composition powders of aforementioned therapies articular trauma property synovitis of the present invention; Comprise the steps: to take by weighing by weight Colophonium, Olibanum, Myrrha, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Natrii Sulfas, Sanguis Draxonis and Borneolum Syntheticum pulverization; With the Chinese liquor modulation, make Dressed medicine powder.
When Chinese medicine composition of the present invention is used to treat articular trauma property synovitis, the external application inflammation part, every day twice, each 3 hours, 15 days was a course of treatment.
The curative effect of Chinese medicine composition of the present invention is through clinical verification, for treatment articular trauma property synovitis, but promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain.Test Example subsequently is also provable, and Chinese medicine composition of the present invention directly acts on the joint synovitis disease position, the dissipation hydrops, and be used to treat articular trauma property synovitis and have following advantage: manufacture method is simple and efficient, is prone to Transdermal absorption; Local application directly acts on skin, does not cause systemic side effects; Good effect is difficult for recurrence; Do not have once more the synovial membrane damage, reduce adhesion; Method is simple, no pain.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.These embodiment are interpreted as only being used to the present invention is described and are not used in restriction protection scope of the present invention.After the content of having read the present invention's record, those skilled in the art can do various changes or modification to the present invention, and these equivalences change and modify and fall into claim of the present invention institute restricted portion equally.
Colophonium: bitter, sweet, warm.Dispeiling pathogenic wind and removing dampness, evacuation of pus is drawn out pus by applying a plaster to the affected part, the granulation promoting pain relieving.Compendium of Material Medica claims that it can " bone and muscle strengthening ".Thousand Golden Prescriptions has Colophonium to control the record of " all wind of severe and migratory arthralgia, hundred joints are ached and can not be born ".
Olibanum: hot, bitter, warm.The hot temperature of loosing is logical, promoting flow of QI and blood pain relieving, detumescence and promoting granulation.Be used for all pains of stagnation of blood stasis, be the key medicine of muscles and tendons relaxing to alleviate pain.Compendium of Material Medica " a surname's pain of invigorating blood circulation is stretched muscle ".But microcirculation improvement and hemorheology, anti-inflammatory and analgesic effect is strong.
Myrrha: bitter, flat.The hot temperature of loosing is logical, promoting flow of QI and blood pain relieving, detumescence and promoting granulation.Compendium of Material Medica " loose blood subduing swelling and relieving pain ", normal double mutually with Olibanum and use.Contain volatile oil, resin etc., its detumescence effect is relevant with the antiinflammatory pharmacological action.
The Radix Angelicae Dahuricae: hot, warm.The wind that looses dehumidifies understand things pain-stopping, detumescence and apocenosis.Fragrance is walked to scurry, and is good at reducing swelling and alleviating pain.
Radix Et Rhizoma Rhei: heat and toxic materials clearing away, clearing away heat-fire, detoxifcation hemostasis, blood circulation promoting and blood stasis dispelling.Shennong's Herbal: " main blood stasis ， Po lumps in the chest and abdomen down ".
Natrii Sulfas: salty in the mouth.Hard masses softening and resolving, reducing swelling and alleviating pain.The existing external application for curing Bone injury disease that is used for more.Have antiinflammatory action, can accelerate lymph circulation, strengthen the skein cell phagocytic function, promote the cicatrix intussusception.
Sanguis Draxonis: sweet, salty, flat.The removing stasis to stop bleeding pain relieving, promoting tissue regeneration and ulcer healing.Cure mainly traumatic injury, blood stasis is had a pain, and is unbearably painful, is the traumatology key medicine.Has anti-inflammatory and analgesic effect.
Borneolum Syntheticum: hot, bitter, be slightly cold, fragrance is walked to scurry, the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain." can cure mirror approximately " called it: " controlling arthrodynia of extremities ".Borneolum Syntheticum is prone to be had good anti-inflammatory analgesic effect by the transdermal intussusception.
Embodiment 1
Take by weighing Colophonium 30g; Olibanum 12g; Myrrha 12g; Radix Angelicae Dahuricae 30g; Radix Et Rhizoma Rhei 30g; Natrii Sulfas 18g; Sanguis Draxonis 3g; Borneolum Syntheticum 3g.Pulverization, and, make application compress powder with the modulation of 40 ° of left and right sides of alcoholic strength Chinese liquor.
Embodiment 2
Take by weighing Colophonium 50g; Olibanum 20g; Myrrha 20g; Radix Angelicae Dahuricae 50g; Radix Et Rhizoma Rhei 50g; Natrii Sulfas 30g; Sanguis Draxonis 5g; Borneolum Syntheticum 5g.Pulverization, and, make application compress powder with the modulation of 40 ° of left and right sides of alcoholic strength Chinese liquor.
Embodiment 3
Take by weighing Colophonium 10g; Olibanum 4g; Myrrha 4g; Radix Angelicae Dahuricae 10g; Radix Et Rhizoma Rhei 10g; Natrii Sulfas 6g; Sanguis Draxonis 1g; Borneolum Syntheticum 1g.Pulverization, and, make application compress powder with the modulation of 40 ° of left and right sides of alcoholic strength Chinese liquor.
The application compress powder that picked at random embodiment 1-3 makes carries out zoopery, and Experiment of Zoology proves that Chinese medicine composition of the present invention has the Repercusion analgesia antiinflammatory, improves effects such as blood index, and articular trauma property synovitis is had certain therapeutical effect.Do not see obvious adverse reaction in the experimentation.
1. pairs of Ovum Gallus domesticus album of Test Example cause the influence experiment of rat swollen joint expansibility.
Get the Wistar rat, body weight 200 ± 20g, right hind joint part depilation external application trial drug, every day 1 time, each 3 hours, continuous use 30 days.Positive control drug is Anisodus carniolicoides C.Y.Wu et C.Chen (Chinese liquor transfer apply), respectively organizes the following volume in rat right hind leg joint with the volumetric method surveying record on the 28th day.Remove blank control group, each aponeurosis (aponeuroses) of organizing the rat right hind leg toes reaches intraarticular injection 10% Ovum Gallus domesticus album suspension down, and every 0.1ml continuous three days, sets up rat arthritis disease swelling model.Ovum Gallus domesticus album causes inflammation half an hour after the last medication, measures in 2 hours, 4 hours, 6 hours, 24 hours behind the record medicine and respectively organizes rat right hind leg swelling degree (the swelling degree is for causing the volumetrical difference of scorching front and back toes).The result sees the following form 1:
Table 1. pair Ovum Gallus domesticus album causes the influence
of rat swollen joint expansibility
Contrast with model group
*P＜0.01.
The result of the test of table 1 shows: Chinese medicine composition of the present invention has certain inhibitory action to rat arthroncus due to the Ovum Gallus domesticus album.
Test Example 2. mice hot plate method analgesic experiments.
Get Kunming mouse, body weight 20 ± 2g, male and female half and half.22 ℃ of room temperatures, aluminium sheet place 55 ± 0.1 ℃ of thermostatic water tanks, prediction mice pain thresholding.The conventional depilation of mice lower back, drug of topical application every day 1 time, each 3 hours, continuous 15 days.0.5h, 1h, 2h after the last drug of topical application survey the pain thresholding.Positive control drug is Anisodus carniolicoides C.Y.Wu et C.Chen (Chinese liquor is transferred and applied).The result sees the following form 2:
Table 2. mice hot plate method analgesia
Contrast with blank control group
*P＜0.05.
The result of the test of table 2 shows: Chinese medicine composition of the present invention can obviously improve the pain territory to the hot plate induced mice.
The influence experiment of 3. pairs of rabbit blood rheologys of Test Example and hydrarthrosis.
Get Japan large ear rabbit, body weight 2.5 ± 0.2kg.Right knee joint intracavitary administration 1.6% papain normal saline solution 0.5ml carries out the injection second time after three days, set up the rabbit knee inflammatory model.Modeling is observed rabbit knee limitation of activity and arthroncus situation after two weeks.The depilation of trial drug group rabbit knee sticks medicine, every day 1 time, each 3 hours, continuous 30 days.Rabbit ear posterior vein is got blood and is carried out analysis of Hemorheology, and positive control drug is Anisodus carniolicoides C.Y.Wu et C.Chen (Chinese liquor is transferred and applied).To arthroedema influence experiment, positive control drug is Anisodus carniolicoides C.Y.Wu et C.Chen (Chinese liquor is transferred and applied) and indomethacin (0.1ml/kg).The result 3-5 that sees the following form:
The influence
of table 3. pair rabbit blood rheology index
With blank control group contrast #
*P＜0.05 is with model group contrast #P＜0.05.
The influence
of table 4. pair rabbit blood rheology index
With blank control group contrast #
*P＜0.05 is with model group contrast #P＜0.05.
The result of the test of table 3-4 shows: medicine of the present invention can improve the hemorheology index of arthritis rabbit model.
The influence of table 5. pair rabbit arthroedema
With model group contrast #P＜0.01; Contrast with the Anisodus carniolicoides C.Y.Wu et C.Chen group
*P＜0.01.
The result of the test of table 5 shows: Chinese medicine composition of the present invention can obviously be eliminated the arthroedema of arthritis rabbit model.
Claims (4)
1. a Chinese medicine composition of treating articular trauma property synovitis is characterized in that, the medicament that is prepared from following raw medicaments in portion by weight: Colophonium 30-50 part; Olibanum 12-20 part; Myrrha 12-20 part; Radix Angelicae Dahuricae 30-50 part; Radix Et Rhizoma Rhei 30-50 part; Natrii Sulfas 18-30 part; Sanguis Draxonis 3-5 part; Borneolum Syntheticum 3-5 part.
2. according to the Chinese medicine composition of the said treatment articular trauma property of claim 1 synovitis, it is characterized in that the weight portion of each crude drug is respectively: 10 parts of Colophonium; 4 parts of Olibanums; 4 parts of Myrrhas; 10 parts of the Radixs Angelicae Dahuricae; 10 parts of Radix Et Rhizoma Rhei; 6 parts in Natrii Sulfas; 1 part of Sanguis Draxonis; 1 part of Borneolum Syntheticum.
3. according to the Chinese medicine composition of claim 1 or 2 said treatment articular trauma property synovitis, it is characterized in that this Chinese medicine composition is a powder.
The said treatment articular trauma property of claim 3 synovitis the method for preparing of Chinese medicine composition; It is characterized in that; Comprise the steps: to take by weighing by weight Colophonium, Olibanum, Myrrha, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Natrii Sulfas, Sanguis Draxonis and Borneolum Syntheticum pulverization, and, make Dressed medicine powder with the Chinese liquor modulation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011100585628A CN102670895A (en) | 2011-03-11 | 2011-03-11 | Chinese medicinal composition for treating joint traumatic synovitis and preparation method thereof |
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| CN2011100585628A CN102670895A (en) | 2011-03-11 | 2011-03-11 | Chinese medicinal composition for treating joint traumatic synovitis and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108452052A (en) * | 2018-03-29 | 2018-08-28 | 青岛市城阳区第二人民医院 | A kind of Cape jasmine breast Nitrate Yellow Powder for treating knee joint osseous arthritis |
| CN108721323A (en) * | 2017-04-18 | 2018-11-02 | 上海昱烁管理咨询有限公司 | A kind of traditional Chinese medicine for external application for treating effusion of knee joint |
| CN110193042A (en) * | 2019-06-17 | 2019-09-03 | 郭珈宜 | A kind of external application medicine composition that treating synovitis and its preparation process |
| CN112206272A (en) * | 2020-11-06 | 2021-01-12 | 李田来 | External cold compress gel for closed soft tissue |
-
2011
- 2011-03-11 CN CN2011100585628A patent/CN102670895A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721323A (en) * | 2017-04-18 | 2018-11-02 | 上海昱烁管理咨询有限公司 | A kind of traditional Chinese medicine for external application for treating effusion of knee joint |
| CN108452052A (en) * | 2018-03-29 | 2018-08-28 | 青岛市城阳区第二人民医院 | A kind of Cape jasmine breast Nitrate Yellow Powder for treating knee joint osseous arthritis |
| CN110193042A (en) * | 2019-06-17 | 2019-09-03 | 郭珈宜 | A kind of external application medicine composition that treating synovitis and its preparation process |
| CN112206272A (en) * | 2020-11-06 | 2021-01-12 | 李田来 | External cold compress gel for closed soft tissue |
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Application publication date: 20120919 |