CN112203660B - 用于治疗银屑病关节炎的方法 - Google Patents
用于治疗银屑病关节炎的方法 Download PDFInfo
- Publication number
- CN112203660B CN112203660B CN201980034599.1A CN201980034599A CN112203660B CN 112203660 B CN112203660 B CN 112203660B CN 201980034599 A CN201980034599 A CN 201980034599A CN 112203660 B CN112203660 B CN 112203660B
- Authority
- CN
- China
- Prior art keywords
- treatment
- patient
- use according
- psoriatic arthritis
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1808575.3A GB201808575D0 (en) | 2018-05-24 | 2018-05-24 | Methods for the treatment of psoriatic arthrits |
| GB1808575.3 | 2018-05-24 | ||
| PCT/EP2019/063283 WO2019224283A1 (en) | 2018-05-24 | 2019-05-23 | Methods for the treatment of psoriatic arthritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112203660A CN112203660A (zh) | 2021-01-08 |
| CN112203660B true CN112203660B (zh) | 2024-12-31 |
Family
ID=62812304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980034599.1A Active CN112203660B (zh) | 2018-05-24 | 2019-05-23 | 用于治疗银屑病关节炎的方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12329758B2 (https=) |
| EP (1) | EP3801548A1 (https=) |
| JP (3) | JP2021524472A (https=) |
| CN (1) | CN112203660B (https=) |
| AU (2) | AU2019273664B2 (https=) |
| CA (1) | CA3101386A1 (https=) |
| GB (1) | GB201808575D0 (https=) |
| MA (1) | MA52738A (https=) |
| WO (1) | WO2019224283A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| EP4178616A4 (en) * | 2020-07-13 | 2024-07-24 | Janssen Biotech, Inc. | SAFE AND EFFECTIVE METHOD FOR TREATING PSORIATIC ARTHRITIS USING A SPECIFIC ANTI-IL23 ANTIBODY |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102482273A (zh) * | 2009-06-26 | 2012-05-30 | 加拉帕戈斯股份有限公司 | 作为jak抑制剂的5-苯基-[1,2,4]三唑并[1,5-a]吡啶-2-甲酰胺化合物 |
| CN104379173A (zh) * | 2012-06-22 | 2015-02-25 | 加拉帕戈斯股份有限公司 | 用于治疗炎症的氨基三唑并吡啶及其药物组合物 |
| WO2015117980A1 (en) * | 2014-02-07 | 2015-08-13 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| CN107531694A (zh) * | 2015-04-13 | 2018-01-02 | 加拉帕戈斯股份有限公司 | 用于治疗炎性疾病的方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000044722A1 (en) | 1999-01-29 | 2000-08-03 | Chugai Seiyaku Kabushiki Kaisha | Chondrongenesis promotors and indolin-2-one derivatives |
| US20040138285A1 (en) | 2001-04-27 | 2004-07-15 | Makoto Okazaki | Chondrogenesis promoters |
| US6514989B1 (en) | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
| JPWO2004039816A1 (ja) | 2002-10-29 | 2006-03-02 | 塩野義製薬株式会社 | セフェム化合物の無機酸塩の結晶 |
| CA2515190A1 (en) | 2003-02-14 | 2004-08-26 | Pfizer Products Inc. | Triazolo-pyridines as anti-inflammatory compounds |
| US20050222171A1 (en) | 2004-01-22 | 2005-10-06 | Guido Bold | Organic compounds |
| US20070004658A1 (en) | 2004-06-21 | 2007-01-04 | Nick Vandeghinste | Method and means for treatment of osteoarthritis |
| EP1786811A2 (en) | 2004-08-18 | 2007-05-23 | Pharmacia & Upjohn Company LLC | Triazolopyridine compounds |
| WO2006038116A2 (en) | 2004-10-07 | 2006-04-13 | Warner-Lambert Company Llc | Triazolopyridine derivatives as antibacterial agents |
| GB0515026D0 (en) | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
| JP5336375B2 (ja) | 2006-08-30 | 2013-11-06 | セルゾーム リミテッド | キナーゼ阻害剤としてのトリアゾール誘導体 |
| CL2008001626A1 (es) | 2007-06-05 | 2009-06-05 | Takeda Pharmaceuticals Co | Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer. |
| US8053574B2 (en) | 2007-07-18 | 2011-11-08 | Novartis Ag | Organic compounds |
| WO2009017954A1 (en) | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibitors of jak2 kinase |
| CA2691448A1 (en) | 2007-08-31 | 2009-03-05 | Dominique Swinnen | Triazolopyridine compounds and their use as ask inhibitors |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| BRPI0909945A2 (pt) | 2008-06-20 | 2015-07-28 | Genentech Inc | "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinase em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase" |
| WO2010010189A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
| WO2010010186A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2010010184A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors |
| WO2010010187A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| WO2010013768A1 (ja) | 2008-07-31 | 2010-02-04 | 第一三共株式会社 | チアゾリジンジオン化合物の結晶及びその製造方法 |
| JP2013049632A (ja) | 2011-08-30 | 2013-03-14 | Kowa Co | ベンゾチアジン化合物のモノマレイン酸塩を有効成分とするアレルギー疾患の予防及び/又は治療剤 |
| SA112330992B1 (ar) | 2011-11-10 | 2015-09-13 | كيورين فارماسوتيكال كو.، ليمتد | صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي |
| US20130310340A1 (en) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| RS64677B1 (sr) | 2015-04-13 | 2023-11-30 | Galapagos Nv | Metode lečenja kardiovaskularnih poremećaja |
| US20170173034A1 (en) * | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders |
| PL3595667T3 (pl) * | 2017-03-14 | 2024-03-18 | Galapagos Nv | Kompozycje farmaceutyczne zawierające inhibitor jak |
-
2018
- 2018-05-24 GB GBGB1808575.3A patent/GB201808575D0/en not_active Ceased
-
2019
- 2019-05-23 AU AU2019273664A patent/AU2019273664B2/en active Active
- 2019-05-23 US US17/057,946 patent/US12329758B2/en active Active
- 2019-05-23 CN CN201980034599.1A patent/CN112203660B/zh active Active
- 2019-05-23 EP EP19726950.9A patent/EP3801548A1/en active Pending
- 2019-05-23 WO PCT/EP2019/063283 patent/WO2019224283A1/en not_active Ceased
- 2019-05-23 MA MA052738A patent/MA52738A/fr unknown
- 2019-05-23 JP JP2020565417A patent/JP2021524472A/ja active Pending
- 2019-05-23 CA CA3101386A patent/CA3101386A1/en active Pending
-
2024
- 2024-02-16 JP JP2024021644A patent/JP7751362B2/ja active Active
-
2025
- 2025-04-22 AU AU2025202777A patent/AU2025202777A1/en active Pending
- 2025-05-13 US US19/206,213 patent/US20260108530A1/en active Pending
- 2025-09-24 JP JP2025157844A patent/JP2025183397A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102482273A (zh) * | 2009-06-26 | 2012-05-30 | 加拉帕戈斯股份有限公司 | 作为jak抑制剂的5-苯基-[1,2,4]三唑并[1,5-a]吡啶-2-甲酰胺化合物 |
| CN104379173A (zh) * | 2012-06-22 | 2015-02-25 | 加拉帕戈斯股份有限公司 | 用于治疗炎症的氨基三唑并吡啶及其药物组合物 |
| WO2015117980A1 (en) * | 2014-02-07 | 2015-08-13 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| CN107531694A (zh) * | 2015-04-13 | 2018-01-02 | 加拉帕戈斯股份有限公司 | 用于治疗炎性疾病的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7751362B2 (ja) | 2025-10-08 |
| AU2019273664B2 (en) | 2025-01-23 |
| EP3801548A1 (en) | 2021-04-14 |
| KR20210013168A (ko) | 2021-02-03 |
| CN112203660A (zh) | 2021-01-08 |
| MA52738A (fr) | 2021-04-14 |
| US12329758B2 (en) | 2025-06-17 |
| AU2019273664A1 (en) | 2021-01-21 |
| US20210299135A1 (en) | 2021-09-30 |
| WO2019224283A1 (en) | 2019-11-28 |
| JP2025183397A (ja) | 2025-12-16 |
| GB201808575D0 (en) | 2018-07-11 |
| JP2021524472A (ja) | 2021-09-13 |
| JP2024069223A (ja) | 2024-05-21 |
| US20260108530A1 (en) | 2026-04-23 |
| AU2025202777A1 (en) | 2025-05-08 |
| CA3101386A1 (en) | 2019-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11524964B2 (en) | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof | |
| US20220267342A1 (en) | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF | |
| US20260108530A1 (en) | Methods for the treatment of psoriatic arthritis | |
| JP2018537418A (ja) | インターロイキン17(il−17)アンタゴニストを用いてx線陰性体軸性脊椎関節炎を治療する方法 | |
| US11773106B2 (en) | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof | |
| TW201821080A (zh) | 用於治療發炎性疾病之化合物及其醫藥組合物 | |
| EP4356963A2 (en) | Treating spondyloarthritic and psoriatic conditions with upadacitinib | |
| KR102955500B1 (ko) | 건선성 관절염의 치료 방법 | |
| Sadeq et al. | Randomized clinical trials on the efficacy and safety of tocilizumab in subjects with Rheumatoid arthritis: a systematic review | |
| RU2852738C1 (ru) | Способы лечения аутоиммунных заболеваний с применением антагонистов интерлейкина-17 (il-17) | |
| US12570664B2 (en) | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof | |
| US20240398790A1 (en) | Treating spondyloarthritic conditions with upadacitinib | |
| Zhang et al. | Preclinical characterization of the selective Jak1 inhibitor Lw402 for treatment of rheumatoid arthritis | |
| Juganaru et al. | Therapeutic options in refractory anti-MDA5+ dermatomyositis triggered by SARS-CoV-2 infection | |
| HK40111335A (en) | Treating spondyloarthritic and psoriatic conditions with upadacitinib | |
| Humby et al. | O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy | |
| Hawkins | 54 Rheumatoid Arthritis and Osteoarthritis | |
| CN120957720A (zh) | 三稠环化合物在制备预防和/或治疗炎性疾病药物中的应用 | |
| Martín-Varillas et al. | AB1017 WHAT IS THE CURRENT SITUATION OF THE PAEDIATRIC RHEUMATOLOGY TRANSITION CARE UNITS? | |
| CN121969374A (zh) | 使用ly3871801治疗自身免疫性和炎症性疾病的剂量方案 | |
| TW202511290A (zh) | 一種重組抗IL-23p19抗體治療中重度銀屑病的方法 | |
| Dragoi et al. | OP0173 Inspiratory Muscle Training as a Method for Improving Aerobic Capacity and Pulmonary Function in Patients with Ankylosing Spondylitis: A Randomized Controlled Study | |
| JPWO2019224283A5 (https=) | ||
| Mohammed | Anti-CD-20 Therapy in Refractory Adult Still’s Disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20240403 Address after: Bologna, Italy Applicant after: ALFASIGMA S.P.A. Country or region after: Italy Address before: Mechelen Applicant before: GALAPAGOS N.V. Country or region before: Belgium |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |