CN112195169A - 包含重组人凝血因子Xa蛋白的异质性群体的组合物 - Google Patents

包含重组人凝血因子Xa蛋白的异质性群体的组合物 Download PDF

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Publication number
CN112195169A
CN112195169A CN202011112690.1A CN202011112690A CN112195169A CN 112195169 A CN112195169 A CN 112195169A CN 202011112690 A CN202011112690 A CN 202011112690A CN 112195169 A CN112195169 A CN 112195169A
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China
Prior art keywords
seq
heavy chain
amino acids
light
protein sequences
Prior art date
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Pending
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CN202011112690.1A
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English (en)
Chinese (zh)
Inventor
M·A·扬科斯基
K·A·约翰逊
W·C·皮阿森扎
J·C·罗斯
M·沙马施金
P·J·夏泊
M·B·斯威泽
S·B·韦斯顿
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Pfizer Inc
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Pfizer Inc
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Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CN112195169A publication Critical patent/CN112195169A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Water Supply & Treatment (AREA)
  • Toxicology (AREA)
CN202011112690.1A 2013-09-24 2014-09-16 包含重组人凝血因子Xa蛋白的异质性群体的组合物 Pending CN112195169A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361881834P 2013-09-24 2013-09-24
US61/881,834 2013-09-24
CN201480052212.2A CN105579468A (zh) 2013-09-24 2014-09-16 包含重组人凝血因子Xa蛋白的异质性群体的组合物

Related Parent Applications (1)

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CN201480052212.2A Division CN105579468A (zh) 2013-09-24 2014-09-16 包含重组人凝血因子Xa蛋白的异质性群体的组合物

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Publication Number Publication Date
CN112195169A true CN112195169A (zh) 2021-01-08

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CN202011112690.1A Pending CN112195169A (zh) 2013-09-24 2014-09-16 包含重组人凝血因子Xa蛋白的异质性群体的组合物
CN201480052212.2A Pending CN105579468A (zh) 2013-09-24 2014-09-16 包含重组人凝血因子Xa蛋白的异质性群体的组合物

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US (3) US9757434B2 (enExample)
EP (1) EP3049434A1 (enExample)
JP (1) JP6429885B2 (enExample)
KR (1) KR101988705B1 (enExample)
CN (2) CN112195169A (enExample)
AR (1) AR097732A1 (enExample)
AU (1) AU2014326257B2 (enExample)
BR (1) BR112016005899A8 (enExample)
CA (1) CA2924981C (enExample)
HK (1) HK1218760A1 (enExample)
IL (2) IL244258A0 (enExample)
MX (1) MX373466B (enExample)
MY (1) MY173548A (enExample)
PE (1) PE20160877A1 (enExample)
RU (1) RU2648144C2 (enExample)
SA (1) SA516370751B1 (enExample)
SG (1) SG11201601221XA (enExample)
TW (1) TWI631134B (enExample)
WO (1) WO2015044836A1 (enExample)

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Publication number Priority date Publication date Assignee Title
HK1215196A1 (zh) 2013-01-31 2016-08-19 辉瑞公司 用於抵消因子xa抑制的组合物和方法
CN112195169A (zh) 2013-09-24 2021-01-08 辉瑞大药厂 包含重组人凝血因子Xa蛋白的异质性群体的组合物
EP3926044B1 (en) 2016-06-17 2025-06-04 Alexion Pharmaceuticals, Inc. Preparation of factor xa derivatives
EP3722418A1 (en) * 2019-04-08 2020-10-14 AB Enzymes Oy Solution stable enzyme composition
EP4127158A2 (en) * 2020-04-02 2023-02-08 Takeda Pharmaceutical Company Limited Adamts13 variant, compositions, and uses thereof

Citations (2)

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CN102316893A (zh) * 2008-11-14 2012-01-11 博尔托拉制药公司 因子Xa抑制剂的解毒剂及其与血液凝固剂组合使用的方法

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AT405516B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
AT410216B (de) 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
AU2001249389A1 (en) 2000-03-22 2001-10-03 The Children's Hospital Of Philadelphia Modified blood clotting factors and methods of use
FR2831170B1 (fr) 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
FR2841904B1 (fr) 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
RU2396347C2 (ru) * 2004-08-17 2010-08-10 Ксл Бехринг Гмбх Модифицированные витамин к-зависимые полипептиды
EP1728798A1 (en) 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
MX336958B (es) * 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
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HK1215196A1 (zh) 2013-01-31 2016-08-19 辉瑞公司 用於抵消因子xa抑制的组合物和方法
CN112195169A (zh) 2013-09-24 2021-01-08 辉瑞大药厂 包含重组人凝血因子Xa蛋白的异质性群体的组合物
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CN105934250A (zh) 2014-01-24 2016-09-07 辉瑞公司 治疗脑内出血的组合物和方法

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CN101802188A (zh) * 2007-09-28 2010-08-11 普托拉制药有限公司 用于因子xa抑制剂的解毒剂和其使用方法
CN102559644A (zh) * 2007-09-28 2012-07-11 普托拉制药有限公司 用于因子xa抑制剂的解毒剂和其使用方法
CN102316893A (zh) * 2008-11-14 2012-01-11 博尔托拉制药公司 因子Xa抑制剂的解毒剂及其与血液凝固剂组合使用的方法

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Publication number Publication date
TW201524996A (zh) 2015-07-01
HK1218760A1 (zh) 2017-03-10
JP2016535071A (ja) 2016-11-10
MX373466B (es) 2020-05-25
US20210106658A1 (en) 2021-04-15
BR112016005899A2 (pt) 2017-09-26
RU2016108608A (ru) 2017-10-26
EP3049434A1 (en) 2016-08-03
SA516370751B1 (ar) 2018-04-05
US20170333535A1 (en) 2017-11-23
CA2924981C (en) 2020-03-31
KR101988705B1 (ko) 2019-06-12
RU2648144C2 (ru) 2018-03-22
CN105579468A (zh) 2016-05-11
PE20160877A1 (es) 2016-09-11
AR097732A1 (es) 2016-04-13
US10660946B2 (en) 2020-05-26
IL279396A (en) 2021-01-31
US20150182604A1 (en) 2015-07-02
IL244258A0 (en) 2016-04-21
AU2014326257B2 (en) 2017-08-10
MY173548A (en) 2020-02-04
SG11201601221XA (en) 2016-04-28
JP6429885B2 (ja) 2018-11-28
BR112016005899A8 (pt) 2018-02-06
MX2016003871A (es) 2016-08-04
CA2924981A1 (en) 2015-04-02
TWI631134B (zh) 2018-08-01
US9757434B2 (en) 2017-09-12
AU2014326257A1 (en) 2016-03-10
WO2015044836A1 (en) 2015-04-02
KR20160044034A (ko) 2016-04-22

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Application publication date: 20210108