CN112189009B - 作为tcr-nck相互作用的抑制剂的色烯衍生物 - Google Patents

作为tcr-nck相互作用的抑制剂的色烯衍生物 Download PDF

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CN112189009B
CN112189009B CN201980020981.7A CN201980020981A CN112189009B CN 112189009 B CN112189009 B CN 112189009B CN 201980020981 A CN201980020981 A CN 201980020981A CN 112189009 B CN112189009 B CN 112189009B
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compound
pharmaceutically acceptable
acceptable salt
compounds
leukemia
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CN112189009A (zh
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J·卡斯特罗
A·加格特马特奥斯
P·J·梅钦
C·L·范德伍森
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Artax Biopharma Inc
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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  • Orthopedic Medicine & Surgery (AREA)
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  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201980020981.7A 2018-02-27 2019-02-27 作为tcr-nck相互作用的抑制剂的色烯衍生物 Active CN112189009B (zh)

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US201862635834P 2018-02-27 2018-02-27
US62/635,834 2018-02-27
PCT/US2019/019856 WO2019169001A1 (en) 2018-02-27 2019-02-27 Chromene derivatives as inhibitors of tcr-nck interaction

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US (5) US10696663B2 (https=)
EP (1) EP3759086A1 (https=)
JP (3) JP7317032B2 (https=)
KR (2) KR20260028873A (https=)
CN (2) CN112189009B (https=)
AU (2) AU2019229258B2 (https=)
BR (1) BR112020017386A2 (https=)
CA (1) CA3091202A1 (https=)
CO (1) CO2020010537A2 (https=)
EA (1) EA202091742A1 (https=)
IL (2) IL301120B2 (https=)
MX (2) MX2020008814A (https=)
PH (1) PH12020500638A1 (https=)
SG (1) SG11202008067QA (https=)
WO (1) WO2019169001A1 (https=)
ZA (1) ZA202310843B (https=)

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EP3759086A1 (en) 2018-02-27 2021-01-06 Artax Biopharma Inc. Chromene derivatives as inhibitors of tcr-nck interaction
WO2025137442A1 (en) * 2023-12-22 2025-06-26 Artax Biopharma Inc. SOLID AND SALT FORMS OF TCR-NcK MODULATORS AND USES THEREOF
WO2025255109A1 (en) * 2024-06-03 2025-12-11 Artax Biopharma Inc. Combination of a chromene derivative tcr inhibitor and a pde4 inhibitor
WO2025255093A1 (en) * 2024-06-03 2025-12-11 Artax Biopharma Inc. Combination of a car-t therapy and a chromene derivative tcr inhibitor
WO2025255091A1 (en) * 2024-06-03 2025-12-11 Artax Biopharma Inc. Combination of a chromene derivative tcr inhibitor and a jak inhibitor

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