AU2019229258B2 - Chromene derivatives as inhibitors of TCR-Nck interaction - Google Patents

Chromene derivatives as inhibitors of TCR-Nck interaction Download PDF

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AU2019229258B2
AU2019229258B2 AU2019229258A AU2019229258A AU2019229258B2 AU 2019229258 B2 AU2019229258 B2 AU 2019229258B2 AU 2019229258 A AU2019229258 A AU 2019229258A AU 2019229258 A AU2019229258 A AU 2019229258A AU 2019229258 B2 AU2019229258 B2 AU 2019229258B2
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compound
pharmaceutically acceptable
acceptable salt
compounds
nitrogen
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AU2019229258A1 (en
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Julio Castro
Andrés GAGETE MATEOS
Peter J. Machin
Christopher Loren Vandeusen
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Artax Biopharma Inc
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Artax Biopharma Inc
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
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AU2019229258A 2018-02-27 2019-02-27 Chromene derivatives as inhibitors of TCR-Nck interaction Active AU2019229258B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023282201A AU2023282201B2 (en) 2018-02-27 2023-12-12 Chromene derivatives as inhibitors of TCR-Nck interaction

Applications Claiming Priority (3)

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US201862635834P 2018-02-27 2018-02-27
US62/635,834 2018-02-27
PCT/US2019/019856 WO2019169001A1 (en) 2018-02-27 2019-02-27 Chromene derivatives as inhibitors of tcr-nck interaction

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AU2019229258A1 AU2019229258A1 (en) 2020-09-17
AU2019229258B2 true AU2019229258B2 (en) 2023-09-14

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US (5) US10696663B2 (https=)
EP (1) EP3759086A1 (https=)
JP (3) JP7317032B2 (https=)
KR (2) KR20260028873A (https=)
CN (2) CN117304157A (https=)
AU (2) AU2019229258B2 (https=)
BR (1) BR112020017386A2 (https=)
CA (1) CA3091202A1 (https=)
CO (1) CO2020010537A2 (https=)
EA (1) EA202091742A1 (https=)
IL (2) IL301120B2 (https=)
MX (2) MX2020008814A (https=)
PH (1) PH12020500638A1 (https=)
SG (1) SG11202008067QA (https=)
WO (1) WO2019169001A1 (https=)
ZA (1) ZA202310843B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20260028873A (ko) 2018-02-27 2026-03-04 아텍스 바이오파마 인코포레이티드 Tcr-nck 상호 작용의 억제제로서의 크로멘 유도체
WO2025137442A1 (en) * 2023-12-22 2025-06-26 Artax Biopharma Inc. SOLID AND SALT FORMS OF TCR-NcK MODULATORS AND USES THEREOF
WO2025255109A1 (en) * 2024-06-03 2025-12-11 Artax Biopharma Inc. Combination of a chromene derivative tcr inhibitor and a pde4 inhibitor
WO2025255091A1 (en) * 2024-06-03 2025-12-11 Artax Biopharma Inc. Combination of a chromene derivative tcr inhibitor and a jak inhibitor
WO2025255093A1 (en) * 2024-06-03 2025-12-11 Artax Biopharma Inc. Combination of a car-t therapy and a chromene derivative tcr inhibitor

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999033825A1 (en) * 1997-12-23 1999-07-08 Merck Patent Gmbh N-phenylamide and n-pyridylamide derivatives, method of preparing them and pharmaceutical compositons containing them
WO2003016270A2 (en) * 2001-08-11 2003-02-27 Bristol-Myers Squibb Pharma Company Selective estrogen receptor modulators
WO2013019926A1 (en) * 2011-08-04 2013-02-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Treatment and prevention of diseases mediated by microorganisms via drug-mediated manipulation of the eicosanoid balance
EP2623503A1 (en) * 2010-09-28 2013-08-07 Consejo Superior De Investigaciones Científicas (CSIC) Chromene derivatives
CN104844471A (zh) * 2015-04-21 2015-08-19 银杏树药业(苏州)有限公司 一种作为dor受体拮抗剂的化合物
EP3059231A1 (en) * 2013-10-18 2016-08-24 Artax Biopharma Inc. Chromene derivatives as inhibitors of tcr-nck interaction
EP3059232A1 (en) * 2013-10-18 2016-08-24 Artax Biopharma Inc. Chromene derivatives substituted by alkoxide as inhibitors of the tcr-nck interaction
WO2016166239A1 (en) * 2015-04-16 2016-10-20 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
TR200401209T4 (tr) 1999-11-05 2004-07-21 Cytovia, Inc. Kaspazların aktivatörleri ve apoptoz endüserleri olarak yer değiştiren 4H-kromen ve analogları ile bunların kullanımı
EP1382339B1 (en) 1999-12-10 2007-12-05 Pfizer Products Inc. Compositions containing pyrrolo ¬2,3-d pyrimidine derivatives
WO2002008217A2 (en) 2000-07-21 2002-01-31 Chugai Seiyaku Kabushiki Kaisha COUMARIN DERIVATIVES USEFUL AS TNFα INHIBITORS
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
EP1389617B1 (en) 2001-04-27 2007-01-03 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and antitumor agent containing the same as active ingredient
WO2002092076A1 (en) 2001-05-16 2002-11-21 Cytovia, Inc. Substituted coumarins and quinolines as caspases activators
WO2003062272A1 (es) 2002-01-24 2003-07-31 Consejo Superior De Investigaciones Científicas Nueva estrategia moduladora de la activacion de los linfocitos t basada en la regulación de la interaccion cd3e- nck.
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
US7476741B2 (en) 2002-05-16 2009-01-13 Cytovia, Inc. Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
WO2004019973A1 (en) 2002-08-14 2004-03-11 Atugen Ag Use of protein kinase n beta
KR20070087266A (ko) 2003-04-03 2007-08-28 세마포르 파머슈티컬즈, 아이엔씨. 피아이-3 키나아제 억제제 프로드러그
CN1832939B (zh) 2003-05-30 2010-04-28 杰明X医药品加拿大公司 用于治疗癌症或病毒病的三杂环化合物、组合物和方法
US7173015B2 (en) 2003-07-03 2007-02-06 The Trustees Of The University Of Pennsylvania Inhibition of Syk kinase expression
SI2612862T1 (sl) 2004-05-13 2017-04-26 Icos Corporation Kinazolini kot inhibitorji humane fosfatidilinozitol 3-kinaze delta
DE602006010979D1 (de) 2005-01-19 2010-01-21 Rigel Pharmaceuticals Inc Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen
EP1888550B1 (en) 2005-05-12 2014-06-25 AbbVie Bahamas Ltd. Apoptosis promoters
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US7402325B2 (en) 2005-07-28 2008-07-22 Phoenix Biotechnology, Inc. Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander
BRPI0617162B8 (pt) 2005-10-07 2021-05-25 Exelixis Inc compostos inibidores de fosfatidilinositol 3-quinase composições farmacêuticas que os contem e métodos de uso dos mesmos
CN103626742B (zh) 2005-11-01 2017-04-26 塔格根公司 激酶的联-芳基间-嘧啶抑制剂
EP2455382B1 (en) 2005-12-13 2016-10-26 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
GB0607389D0 (en) 2006-04-12 2006-05-24 Novartis Ag Organic compounds
MX2008013578A (es) 2006-04-26 2009-03-23 Hoffmann La Roche Derivados de tieno [3,2-d]pirimidina utiles como inhibidores de fosfatidilinositol 3-cinasa(p13k).
BRPI0622054B8 (pt) 2006-09-22 2021-05-25 Oxford Amherst Llc composto e composição farmacêutica
HRP20151386T1 (hr) 2007-03-12 2016-02-26 Ym Biosciences Australia Pty Ltd Fenil aminopirimidinski spojevi i njihova primjena
WO2008118802A1 (en) 2007-03-23 2008-10-02 Regents Of The University Of Minnesota Therapeutic compounds
PE20090717A1 (es) 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
US20110207729A1 (en) * 2007-08-10 2011-08-25 Astellas Pharma Inc. Bicyclic acylguanidine derivative
US8158616B2 (en) 2008-03-11 2012-04-17 Incyte Corporation Azetidine and cyclobutane derivatives as JAK inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
ES2331451B1 (es) 2008-06-30 2010-10-21 Consejo Superior De Investigaciones Cientificas (Csic) Inmunosupresor basado en la interrupcion de la interaccion tcr-nck.
US8759390B2 (en) 2008-07-16 2014-06-24 Bristol-Myers Squibb Company Chromene modulators of chemokine receptor activity
ES2334318B2 (es) 2008-09-05 2011-11-28 Universidad Politécnica de Madrid Sistema de deteccion optica para bio-ensayos de alta sensibilidad sinmarcado.
US8193378B2 (en) 2008-12-05 2012-06-05 Astellas Pharma Inc. 2H-chromene compound and derivative thereof
EP2693164A1 (en) 2012-08-03 2014-02-05 Universidad Politécnica de Madrid Interferometric detection method
KR20260028873A (ko) 2018-02-27 2026-03-04 아텍스 바이오파마 인코포레이티드 Tcr-nck 상호 작용의 억제제로서의 크로멘 유도체

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999033825A1 (en) * 1997-12-23 1999-07-08 Merck Patent Gmbh N-phenylamide and n-pyridylamide derivatives, method of preparing them and pharmaceutical compositons containing them
WO2003016270A2 (en) * 2001-08-11 2003-02-27 Bristol-Myers Squibb Pharma Company Selective estrogen receptor modulators
EP2623503A1 (en) * 2010-09-28 2013-08-07 Consejo Superior De Investigaciones Científicas (CSIC) Chromene derivatives
WO2013019926A1 (en) * 2011-08-04 2013-02-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Treatment and prevention of diseases mediated by microorganisms via drug-mediated manipulation of the eicosanoid balance
EP3059231A1 (en) * 2013-10-18 2016-08-24 Artax Biopharma Inc. Chromene derivatives as inhibitors of tcr-nck interaction
EP3059232A1 (en) * 2013-10-18 2016-08-24 Artax Biopharma Inc. Chromene derivatives substituted by alkoxide as inhibitors of the tcr-nck interaction
WO2016166239A1 (en) * 2015-04-16 2016-10-20 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors
CN104844471A (zh) * 2015-04-21 2015-08-19 银杏树药业(苏州)有限公司 一种作为dor受体拮抗剂的化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ORGANIC LETTERS, 2016, vol. 18, no. 5, pages 944 - 947 *

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