CN112166125A - 全人源的抗lag-3抗体及其应用 - Google Patents

全人源的抗lag-3抗体及其应用 Download PDF

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CN112166125A
CN112166125A CN201980035403.0A CN201980035403A CN112166125A CN 112166125 A CN112166125 A CN 112166125A CN 201980035403 A CN201980035403 A CN 201980035403A CN 112166125 A CN112166125 A CN 112166125A
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seq
sequence
antibody
amino acid
lag
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CN112166125B (zh
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胡化静
缪小牛
张攀
刘军建
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Innovent Biologics Suzhou Co Ltd
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Innovent Biologics Suzhou Co Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

提供的是特异性结合LAG‑3的抗体和抗体片段，以及含有所述抗体或抗体片段的组合物。还提供了编码所述抗体或其抗体片段的核酸及包含其的宿主细胞，以及其治疗和诊断用途。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201980035403.0A 2018-06-19 2019-06-18 全人源的抗lag-3抗体及其应用 Active CN112166125B (zh)

Applications Claiming Priority (3)

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CN201810629554.6A CN110615840A (zh) 2018-06-19 2018-06-19 全人源的抗lag-3抗体及其应用
CN2018106295546 2018-06-19
PCT/CN2019/091749 WO2019242619A1 (zh) 2018-06-19 2019-06-18 全人源的抗lag-3抗体及其应用

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CN112166125A true CN112166125A (zh) 2021-01-01
CN112166125B CN112166125B (zh) 2022-09-27

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TW (1) TWI721457B (zh)
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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113348182B (zh) * 2019-12-30 2022-07-12 上海海路生物技术有限公司 Lag-3抗体及其医药用途
CN114907478A (zh) * 2021-02-08 2022-08-16 迈威(上海)生物科技股份有限公司 结合lag-3的抗体及其用途
CN113603779B (zh) * 2021-08-18 2023-06-02 深圳市元谷生物科技有限公司 一种结合人淋巴细胞活化基因3(lag-3)的抗体及其用途
MX2024003936A (es) * 2021-09-29 2024-06-28 Akeso Biopharma Inc Anticuerpo anti-lag3, composicion farmaceutica y uso.
TW202334218A (zh) * 2021-11-01 2023-09-01 中國大陸商科望（蘇州）生物醫藥科技有限公司 新型抗ｌａｇ３抗體

Citations (4)

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CN102176921A (zh) * 2008-08-11 2011-09-07 梅达雷克斯股份有限公司 结合淋巴细胞活化基因3(lag-3)之人类抗体及其用途
TW201800419A (zh) * 2016-06-23 2018-01-01 江蘇恆瑞醫藥股份有限公司 Ｌａｇ－３抗體、其抗原結合片段及其醫藥用途
WO2018069500A2 (en) * 2016-10-13 2018-04-19 Symphogen A/S Anti-lag-3 antibodies and compositions
US20180127496A1 (en) * 2015-02-03 2018-05-10 Anaptysbio, Inc. Antibodies directed against lymphocyte activation gene 3 (lag-3)

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UY34887A (es) * 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
NZ711355A (en) * 2013-03-15 2020-06-26 Glaxosmithkline Ip Dev Ltd Anti-lag-3 binding proteins
TWI773646B (zh) * 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
TWI756187B (zh) * 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
CN102176921A (zh) * 2008-08-11 2011-09-07 梅达雷克斯股份有限公司 结合淋巴细胞活化基因3(lag-3)之人类抗体及其用途
US20180127496A1 (en) * 2015-02-03 2018-05-10 Anaptysbio, Inc. Antibodies directed against lymphocyte activation gene 3 (lag-3)
TW201800419A (zh) * 2016-06-23 2018-01-01 江蘇恆瑞醫藥股份有限公司 Ｌａｇ－３抗體、其抗原結合片段及其醫藥用途
WO2018069500A2 (en) * 2016-10-13 2018-04-19 Symphogen A/S Anti-lag-3 antibodies and compositions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HE, YY; RIVARD, CJ; HIRSCH, FR: "Lymphocyte-activation gene-3, an important immune checkpoint in cancer", 《CANCER SCIENCE》 *
KNAUS, HA等: "Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia", 《CURRENT DRUG TARGETS》 *
OK, CY等: "Checkpoint inhibitors in hematological malignancies", 《JOURNAL OF HEMATOLOGY & ONCOLOGY》 *

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WO2019242619A1 (zh) 2019-12-26
CN110615840A (zh) 2019-12-27
TW202016143A (zh) 2020-05-01
TWI721457B (zh) 2021-03-11
CN112166125B (zh) 2022-09-27

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