CN112154031B - 用于剥离哺乳动物卵母细胞的微流体系统和方法 - Google Patents

用于剥离哺乳动物卵母细胞的微流体系统和方法 Download PDF

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CN112154031B
CN112154031B CN201980033958.1A CN201980033958A CN112154031B CN 112154031 B CN112154031 B CN 112154031B CN 201980033958 A CN201980033958 A CN 201980033958A CN 112154031 B CN112154031 B CN 112154031B
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CN112154031A (zh
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翁林岽
格洛丽亚·Y·李
穆罕默德·托纳
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General Hospital Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/027—Devices for injecting semen into animals, e.g. syringes, guns, probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Animal Husbandry (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201980033958.1A 2018-04-04 2019-04-04 用于剥离哺乳动物卵母细胞的微流体系统和方法 Active CN112154031B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862652648P 2018-04-04 2018-04-04
US62/652,648 2018-04-04
US201862732884P 2018-09-18 2018-09-18
US62/732,884 2018-09-18
PCT/US2019/025895 WO2019195620A1 (en) 2018-04-04 2019-04-04 Microfluidic systems and methods to denude mammalian oocytes

Publications (2)

Publication Number Publication Date
CN112154031A CN112154031A (zh) 2020-12-29
CN112154031B true CN112154031B (zh) 2023-05-23

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Country Link
US (1) US12383389B2 (https=)
EP (1) EP3774050A4 (https=)
JP (1) JP7539836B2 (https=)
CN (1) CN112154031B (https=)
AU (1) AU2019247412B2 (https=)
CA (1) CA3096048A1 (https=)
IL (1) IL277771A (https=)
WO (1) WO2019195620A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN116171137A (zh) 2020-07-06 2023-05-26 康奈尔大学 用于自动化微流体卵母细胞剥脱的方法和装置
WO2022081966A1 (en) * 2020-10-16 2022-04-21 Overture Life, Inc. Microfluidic devices and methods for denudation of cells
US20250154454A1 (en) * 2021-12-20 2025-05-15 The General Hospital Corporation Microfluidic systems and methods for isolating target entities
WO2025034894A1 (en) * 2023-08-08 2025-02-13 Autoivf, Inc. Devices and methods for isolation of biological entities in suspension

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CN102438647A (zh) * 2009-05-12 2012-05-02 生物相容英国有限公司 使用编码和分泌神经保护因子和/或抗血管形成因子的包囊细胞治疗眼疾病
WO2012128717A1 (en) * 2011-03-18 2012-09-27 National University Of Singapore Isolating target cells from a biological fluid
WO2017131254A1 (ko) * 2016-01-28 2017-08-03 (주)바이오필리아 유전자 또는 생물학적 물질의 분리 및 검사 키트

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US4802591A (en) 1986-08-29 1989-02-07 Rotex, Inc. Louvered chip screener
IL146072A0 (en) 1999-04-23 2002-07-25 Monica Palacios Boyce Microelectromechanical devices useful for manipulating cells or embryos, kits thereof, methods of making same, and methods of use thereof
US20060128006A1 (en) * 1999-11-10 2006-06-15 Gerhardt Antimony L Hydrodynamic capture and release mechanisms for particle manipulation
CA2408616C (en) * 2000-05-12 2007-10-02 The Board Of Trustees Of The University Of Illinois Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation
US6648917B2 (en) * 2001-10-17 2003-11-18 Medicinelodge, Inc. Adjustable bone fusion implant and method
WO2006031385A2 (en) * 2004-08-24 2006-03-23 The General Hospital Corporation Particle separating devices, systems and methods
GB0505377D0 (en) * 2005-03-16 2005-04-20 Robio Systems Ltd Capilliary devices for cell and embryo culture
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
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UY31720A1 (es) * 2008-03-19 2009-09-30 Procedimiento y aparato para separar particulas en un fluido
KR20120096175A (ko) * 2011-02-22 2012-08-30 엘지전자 주식회사 태양전지 모듈용 프레임 시스템
AU2012271412A1 (en) * 2011-06-15 2014-01-09 Jeffrey T. Borenstein Device and method for culturing cells in a biomimetic environment
PT2768942T (pt) * 2011-10-17 2020-01-21 Massachusetts Inst Technology Entrega intracelular
ES2725825T3 (es) 2012-04-16 2019-09-27 Univ Cornell Sistema de fertilización asistida por inyección de esperma intracitoplasmática automatizada
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CA2966623C (en) * 2014-11-03 2024-02-20 The General Hospital Corporation Concentrating particles in a microfluidic device
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CN102438647A (zh) * 2009-05-12 2012-05-02 生物相容英国有限公司 使用编码和分泌神经保护因子和/或抗血管形成因子的包囊细胞治疗眼疾病
WO2012128717A1 (en) * 2011-03-18 2012-09-27 National University Of Singapore Isolating target cells from a biological fluid
WO2017131254A1 (ko) * 2016-01-28 2017-08-03 (주)바이오필리아 유전자 또는 생물학적 물질의 분리 및 검사 키트

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Publication number Publication date
IL277771A (en) 2020-11-30
EP3774050A4 (en) 2021-06-30
EP3774050A1 (en) 2021-02-17
JP7539836B2 (ja) 2024-08-26
AU2019247412B2 (en) 2023-07-06
WO2019195620A1 (en) 2019-10-10
US20210161635A1 (en) 2021-06-03
AU2019247412A1 (en) 2020-10-29
US12383389B2 (en) 2025-08-12
CN112154031A (zh) 2020-12-29
CA3096048A1 (en) 2019-10-10
JP2021520785A (ja) 2021-08-26

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