AU2019247412B2 - Microfluidic systems and methods to denude mammalian oocytes - Google Patents

Microfluidic systems and methods to denude mammalian oocytes Download PDF

Info

Publication number
AU2019247412B2
AU2019247412B2 AU2019247412A AU2019247412A AU2019247412B2 AU 2019247412 B2 AU2019247412 B2 AU 2019247412B2 AU 2019247412 A AU2019247412 A AU 2019247412A AU 2019247412 A AU2019247412 A AU 2019247412A AU 2019247412 B2 AU2019247412 B2 AU 2019247412B2
Authority
AU
Australia
Prior art keywords
stage
width
teeth
microns
channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2019247412A
Other languages
English (en)
Other versions
AU2019247412A1 (en
Inventor
Gloria Y. LEE
Mehmet Toner
Lindong WENG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of AU2019247412A1 publication Critical patent/AU2019247412A1/en
Application granted granted Critical
Publication of AU2019247412B2 publication Critical patent/AU2019247412B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/027—Devices for injecting semen into animals, e.g. syringes, guns, probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Animal Husbandry (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AU2019247412A 2018-04-04 2019-04-04 Microfluidic systems and methods to denude mammalian oocytes Active AU2019247412B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862652648P 2018-04-04 2018-04-04
US62/652,648 2018-04-04
US201862732884P 2018-09-18 2018-09-18
US62/732,884 2018-09-18
PCT/US2019/025895 WO2019195620A1 (en) 2018-04-04 2019-04-04 Microfluidic systems and methods to denude mammalian oocytes

Publications (2)

Publication Number Publication Date
AU2019247412A1 AU2019247412A1 (en) 2020-10-29
AU2019247412B2 true AU2019247412B2 (en) 2023-07-06

Family

ID=68101522

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019247412A Active AU2019247412B2 (en) 2018-04-04 2019-04-04 Microfluidic systems and methods to denude mammalian oocytes

Country Status (8)

Country Link
US (1) US12383389B2 (https=)
EP (1) EP3774050A4 (https=)
JP (1) JP7539836B2 (https=)
CN (1) CN112154031B (https=)
AU (1) AU2019247412B2 (https=)
CA (1) CA3096048A1 (https=)
IL (1) IL277771A (https=)
WO (1) WO2019195620A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116171137A (zh) 2020-07-06 2023-05-26 康奈尔大学 用于自动化微流体卵母细胞剥脱的方法和装置
WO2022081966A1 (en) * 2020-10-16 2022-04-21 Overture Life, Inc. Microfluidic devices and methods for denudation of cells
US20250154454A1 (en) * 2021-12-20 2025-05-15 The General Hospital Corporation Microfluidic systems and methods for isolating target entities
WO2025034894A1 (en) * 2023-08-08 2025-02-13 Autoivf, Inc. Devices and methods for isolation of biological entities in suspension

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017055361A1 (en) * 2015-09-28 2017-04-06 Marion Vollmer Medical device for the selective separation of a biological sample
WO2017173373A1 (en) * 2016-03-31 2017-10-05 Massachusetts Institute Of Technology Flow-through microfluidic methods and devices featuring membrane-perturbing surface interactions for intracellular delivery

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4802591A (en) 1986-08-29 1989-02-07 Rotex, Inc. Louvered chip screener
IL146072A0 (en) 1999-04-23 2002-07-25 Monica Palacios Boyce Microelectromechanical devices useful for manipulating cells or embryos, kits thereof, methods of making same, and methods of use thereof
US20060128006A1 (en) * 1999-11-10 2006-06-15 Gerhardt Antimony L Hydrodynamic capture and release mechanisms for particle manipulation
CA2408616C (en) * 2000-05-12 2007-10-02 The Board Of Trustees Of The University Of Illinois Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation
US6648917B2 (en) * 2001-10-17 2003-11-18 Medicinelodge, Inc. Adjustable bone fusion implant and method
WO2006031385A2 (en) * 2004-08-24 2006-03-23 The General Hospital Corporation Particle separating devices, systems and methods
GB0505377D0 (en) * 2005-03-16 2005-04-20 Robio Systems Ltd Capilliary devices for cell and embryo culture
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
UY31720A1 (es) * 2008-03-19 2009-09-30 Procedimiento y aparato para separar particulas en un fluido
SG184592A1 (en) * 2011-03-18 2012-10-30 Univ Singapore Isolating target cells from a biological fluid
EP2251028A1 (en) * 2009-05-12 2010-11-17 Biocompatibles Uk Ltd. Treatment of eye diseases using encapsulated cells encoding and secreting an anti-angiogenic factor and/or a neuroprotective factor
KR20120096175A (ko) * 2011-02-22 2012-08-30 엘지전자 주식회사 태양전지 모듈용 프레임 시스템
AU2012271412A1 (en) * 2011-06-15 2014-01-09 Jeffrey T. Borenstein Device and method for culturing cells in a biomimetic environment
PT2768942T (pt) * 2011-10-17 2020-01-21 Massachusetts Inst Technology Entrega intracelular
ES2725825T3 (es) 2012-04-16 2019-09-27 Univ Cornell Sistema de fertilización asistida por inyección de esperma intracitoplasmática automatizada
US9580678B2 (en) * 2013-06-21 2017-02-28 The Regents Of The University Of California Microfluidic tumor tissue dissociation device
US10137673B2 (en) * 2013-12-31 2018-11-27 Canon U.S. Life Sciences, Inc. Methods and systems for continuous flow cell lysis in a microfluidic device
CN104055560B (zh) * 2014-07-06 2016-03-02 长沙傲图生物科技有限公司 一种电动剥卵装置及其剥卵方法
CA2966623C (en) * 2014-11-03 2024-02-20 The General Hospital Corporation Concentrating particles in a microfluidic device
WO2017131254A1 (ko) * 2016-01-28 2017-08-03 (주)바이오필리아 유전자 또는 생물학적 물질의 분리 및 검사 키트

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017055361A1 (en) * 2015-09-28 2017-04-06 Marion Vollmer Medical device for the selective separation of a biological sample
WO2017173373A1 (en) * 2016-03-31 2017-10-05 Massachusetts Institute Of Technology Flow-through microfluidic methods and devices featuring membrane-perturbing surface interactions for intracellular delivery

Also Published As

Publication number Publication date
IL277771A (en) 2020-11-30
EP3774050A4 (en) 2021-06-30
EP3774050A1 (en) 2021-02-17
JP7539836B2 (ja) 2024-08-26
WO2019195620A1 (en) 2019-10-10
US20210161635A1 (en) 2021-06-03
AU2019247412A1 (en) 2020-10-29
US12383389B2 (en) 2025-08-12
CN112154031A (zh) 2020-12-29
CA3096048A1 (en) 2019-10-10
CN112154031B (zh) 2023-05-23
JP2021520785A (ja) 2021-08-26

Similar Documents

Publication Publication Date Title
AU2019247412B2 (en) Microfluidic systems and methods to denude mammalian oocytes
CN102083997B (zh) 用于分离颗粒的方法和设备
AU2010246381B2 (en) Methods and apparatus for segregation of particles
JP7161499B2 (ja) 運動細胞を分離する装置および方法
US20230399601A1 (en) Microfluidic devices and methods for denudation of cells
CN113518818B (zh) 细胞培养装置及其使用方法
DK2076157T3 (en) DISPERSION DEVICES FOR AGGREGATES
US20250033052A1 (en) Device and Method for Splitting Three-Dimensional Agglomerates
EA040069B1 (ru) Микрофлюидные системы и способы для денудации ооцитов млекопитающих
CN109943467A (zh) 一种辅助体外受精的微流控生殖芯片
DE102022213554B4 (de) Vorrichtung und Verfahren zum Splitten dreidimensionaler Agglomerate
JP2022528958A (ja) 植物材料のスクリーニングおよび繁殖のための方法、システム、および装置
US20250043221A1 (en) Device and Method for Splitting Three-Dimensional Agglomerates
WO2025034867A1 (en) Microfluidic methods and apparatuses for denudation of oocytes utilizing oscillatory flow
WO2011028483A2 (en) Methods and apparatus for segregation of particles, including additional sources of sample collection for separation of nucleated fetal cells
Schiewe An effective, simplified, and practical approach to intracytoplasmic sperm injection at multiple IVF centers

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)