CN112076261A - Traditional Chinese medicine composition for treating distal radius fracture and pharmaceutical application thereof - Google Patents
Traditional Chinese medicine composition for treating distal radius fracture and pharmaceutical application thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract
The invention discloses a traditional Chinese medicine composition for treating distal radius fracture and pharmaceutical application thereof. The Chinese medicinal composition is prepared from the following raw material medicaments in part by weight: 90-110 parts of pepper, 20-40 parts of fennel, 10-20 parts of rhizoma atractylodis, 10-20 parts of green tangerine peel and 3-8 parts of cinnamon. The experimental result shows that the traditional Chinese medicine composition can effectively treat distal radius fracture, and the total effective rate is up to 90%; the traditional Chinese medicine composition can also effectively promote the rehabilitation of the wrist joint function of a patient with distal radius fracture (the excellent rate is up to 90%), and has an excellent treatment effect on wrist joint dysfunction caused by distal radius fracture. Therefore, the traditional Chinese medicine composition has wide application prospect in preparing medicines for treating fractures (especially distal radius fractures) and medicines for treating joint dysfunction (especially wrist joint dysfunction caused by distal radius fractures).
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating distal radius fracture and pharmaceutical application thereof.
Background
The distal radius fracture refers to a fracture within 3cm from the distal radius joint surface, is one of the most common clinical fractures, and accounts for about 72% of forearm fracture and 8% -17% of limb fracture. Distal radius fractures can occur at various ages, most commonly in people over 60 years of age, and are significantly more common in female patients than in male patients. Improper treatment of distal radius fracture can easily induce dysfunction of finger joints and wrist joints, and severe patients can also cause dysfunction of shoulder joints or elbow joints, which seriously reduces the life quality of patients.
At present, the treatment of distal radius fractures mainly comprises conservative treatment and surgical treatment. For some far-end radius fractures with extreme instability, such as complex intra-articular fractures (AO/ASIF type C2 and C3), surgical incision reduction and internal fixation are required; the goal of surgical treatment is to achieve anatomical reduction to reduce the incidence of traumatic arthritis. The operation treatment method mainly comprises two methods of percutaneous puncture needle internal fixation, external fixation bracket fixation and incision reduction steel plate internal fixation. Wherein, the simple percutaneous needle-threading internal fixation operation is simple, the taking out is easy, but the fixation is not firm, and the percutaneous needle-threading internal fixation operation is less used clinically at present; in addition, although the external fixation bracket is simple to operate, the displacement of the volar fracture block is not easy to control, and the risks of injury of the superficial radial nerve branch, joint stiffness, needle tract infection, secondary severe osteoporosis and the like exist after the operation, so the external fixation bracket should be used with caution. The incision reduction steel plate is stable and reliable in internal fixation, can perform wrist joint function exercise in early stage, and is suitable for most of distal radius fractures. However, it is not easily accepted by patients due to the trauma caused by the operation and the long recovery time. And since distal radius fractures are most likely to occur in the elderly, they are often reluctant to undergo surgery or are physically unsuitable for surgery.
Thus, for distal radius fractures without significant displacement, conservative treatment has become common. The traditional Chinese medicine conservative treatment has many advantages, such as small wound, good curative effect and the like, and the common traditional Chinese medicine conservative treatment methods include reduction, splint external fixation, medication, traditional Chinese medicine function exercise and the like.
The fumigation and washing method is a medicinal treatment method which utilizes the medicine decoction to fumigate and wash the skin or the affected part by heat. The therapy acts on human body through skin and mucosa with the help of drug potency and heat, promotes the dredging of striae, the mediation of venation and the smooth of qi and blood, thereby achieving the purposes of preventing and treating diseases and avoiding the trauma and pain caused by operation treatment.
Weining (influence of the haitong skin soup fumigation on wrist joint function recovery at the later stage of radius distal end fracture) is prepared from garden balsam stem, clematis root, haitong skin, wine-processed Chinese angelica, 15g of sappan wood, 10g of ligusticum wallichii, angelica dahurica, safflower, cassia twig, divaricate saposhnikovia root and myrrh and 5g of liquorice as raw material medicines, and the haitong skin soup fumigation has an important promotion effect on wrist joint function recovery at the later stage of radius distal end fracture, can effectively prevent and reduce complications, and is worthy of being widely applied to clinic. However, the raw material medicines of the erythrina bark decoction are complex in composition, comprise 12 raw material medicines, and are high in preparation cost; moreover, the curative effect of the erythrina bark decoction on the wrist joint function of patients with distal radius fracture is only 78.4 percent, and needs to be further improved.
At present, no report on the application of a traditional Chinese medicine composition consisting of 5 raw medicines of pepper, fennel, rhizoma atractylodis, green tangerine orange peel and cinnamon in the treatment of distal radius fracture is found.
Disclosure of Invention
The invention aims to provide a pepper cold-dispelling pain-relieving fumigation and washing formula and application thereof in preparation of a medicine for treating distal radius fracture.
The invention provides a traditional Chinese medicine composition which is prepared from the following raw material medicines in parts by weight: 90-110 parts of pepper, 20-40 parts of fennel, 10-20 parts of rhizoma atractylodis, 10-20 parts of green tangerine peel and 3-8 parts of cinnamon.
Further, the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 100 parts of pepper, 30 parts of fennel, 15 parts of rhizoma atractylodis, 15 parts of green tangerine peel and 5 parts of cinnamon.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) preparing medicinal powder of raw materials, and water extract or organic solvent extract of raw materials.
Further, the preparation method of the water extract of the bulk drugs comprises the following steps: decocting the raw materials in water, collecting aromatic water and decoction, and concentrating or drying; wherein the aromatic water is mixture of volatile oil and water vapor distilled during decoction; the decoction is the filtrate left after decoction and filtration;
preferably, the decocting times are 1-2 times, the weight of water added in each time is 2-3 times of the weight of the raw material medicine, and the decocting time is 0.5-1 hour.
The invention also provides a medicament for treating fracture, which is a preparation prepared from the traditional Chinese medicine composition as an active ingredient and pharmaceutically acceptable auxiliary materials.
Further, the preparation is an external preparation;
further, the external preparation is a fumigant, a lotion, a poultice, a liniment, a patch or a drop, preferably a lotion.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating fracture, and preferably, the fracture is distal radius fracture.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating joint dysfunction, preferably, the joint dysfunction is finger joint dysfunction, wrist joint dysfunction, shoulder joint dysfunction or elbow joint dysfunction.
Further, the joint dysfunction is wrist joint dysfunction caused by distal radius fracture.
Joint dysfunction refers to the inability of a joint to function properly due to reduced range of motion or weakness, usually resulting from injury to bones, joints, muscles, and vascular nerves. The joint dysfunction includes finger joint dysfunction, wrist joint dysfunction, shoulder joint dysfunction, elbow joint dysfunction, etc.
The traditional Chinese medicine composition provided by the invention is composed of 5 raw materials of pepper, fennel, rhizoma atractylodis, green tangerine peel and cinnamon. In the Chinese medicinal composition, the pepper has the effects of warming middle-jiao and relieving pain, killing parasites and relieving itching, and the common fennel has the effects of dispelling cold and relieving pain, regulating qi and harmonizing stomach, and is a monarch drug together; the rhizoma atractylodis has the effects of expelling wind and clearing away cold, is commonly used for treating rheumatic arthralgia, and is used as a ministerial drug; the pericarpium citri reticulatae viride is used as an adjuvant drug for soothing the liver and breaking qi, the cinnamon is used for dispelling cold and relieving pain and warming and activating meridians, all the raw materials supplement each other, and the pericarpium citri reticulatae viride has an excellent effect in treating distal radius fracture. The traditional Chinese medicine composition is prepared into the fumigation lotion, is convenient to use and has a remarkable curative effect.
The experimental result shows that the Chinese medicinal composition for fumigation can effectively treat distal radius fracture, and the total effective rate is up to 90%; the traditional Chinese medicine composition can also effectively promote the rehabilitation of the wrist joint function of a patient with distal radius fracture (the excellent rate is up to 90%), and has an excellent treatment effect on wrist joint dysfunction caused by distal radius fracture. Therefore, the traditional Chinese medicine composition has wide application prospect in preparing medicines for treating fractures (especially distal radius fractures) and medicines for treating joint dysfunction (especially wrist joint dysfunction caused by distal radius fractures).
The traditional Chinese medicine composition has the advantages of easily available raw materials, simple composition and simple preparation process, and is suitable for industrial production.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
The raw materials and equipment used in the invention are known products and are obtained by purchasing commercial products.
Example 1 preparation of the Chinese medicinal composition of the present invention
The formula is as follows: 100g of pepper, 30g of fennel, 15g of rhizoma atractylodis, 15g of green tangerine peel and 5g of cinnamon.
The preparation process comprises the following steps: weighing the raw materials according to the formula proportion, adding water, decocting twice, and collecting distilled volatile oil and water vapor while decocting to obtain aromatic water; adding 3 times of water for the first time, decocting for 0.5h, adding 2 times of water for the second time, decocting for 0.5h, filtering, mixing the filtrate with aromatic water, concentrating to 500mL, mixing, packaging, and sterilizing.
Example 2 preparation of the Chinese medicinal composition of the present invention
The formula is as follows: 120g of pepper, 60g of fennel, 10g of rhizoma atractylodis, 10g of green tangerine peel and 8g of cinnamon.
The preparation process comprises the following steps: the same as in example 1.
Example 3 preparation of the Chinese medicinal composition of the present invention
The formula is as follows: 80g of pepper, 20g of fennel, 20g of rhizoma atractylodis, 20g of green tangerine peel and 3g of cinnamon.
The preparation process comprises the following steps: the same as in example 1.
The beneficial effects of the traditional Chinese medicine composition of the invention are demonstrated by experiments below.
Experimental example 1: the traditional Chinese medicine composition has the effect of treating distal radius fracture
1. Experimental methods
(1) Case selection
400 distal radius fracture patients meeting the standard are selected, who voluntarily receive observation and have good compliance with the research method from 10 months in 2019 to 9 months in 2020. The Chinese medicine diagnosis standard refers to the Chinese medicine industry Standard of the people's republic of China, the "Standard of curative Effect for diagnosis of disease and syndrome of traditional Chinese medicine" (ZY/T001.9-94).
Inclusion criteria were:
firstly, belongs to fresh closed fracture without other combined injuries;
the treatment methods are manual reduction, small splint external fixation, rehabilitation exercise and the like;
the patient is willing to cooperate with the experiment to know the treatment and examination scheme and sign an informed consent;
fourthly, no contraindication is caused to the treatment scheme.
Exclusion criteria:
open, old or pathological distal radius fracture;
② diseases accompanied with serious osteoporosis, malnutrition, diabetes and the like which can affect fracture healing;
③ mental disorders or confusion;
fourthly, contraindications exist: such as contraindicated in pregnancy.
(2) Grouping
The 400 patients enrolled were divided into 2 groups:
control group: 100 cases of the Qiang pepper fumigation-washing powder group;
observation group: 100 cases of the Chinese prickly ash incense fumigating and washing formula for dispelling cold and relieving pain.
(3) Method of treatment
After signing the informed consent, the patients were divided into two groups by single and double numbers according to the clinical treatment sequence, the odd group was the observation group, and the even group was the control group.
The observation group was treated with the pepper-fragrance cold-dispelling pain-relieving fumigation and washing formula (i.e., the Chinese medicinal composition of example 1). The treatment method of the pepper cold-dispelling pain-relieving fumigation and washing formula comprises the following steps: the fracture part is fumigated and washed by a fumigation and washing method with pepper fragrance for dispelling cold and relieving pain every day, wherein fumigation is carried out first and then washing is carried out twice a day, 10-15 min is carried out each time, and 500mL is used each time. 7 days is a treatment course, and two treatment courses are continued.
The control group was topically wet-coated with magnesium sulfate. The traditional Chinese medicine composition is taken twice a day, 10-15 min is taken each time, and 7 days are a treatment course and two continuous treatment courses.
(4) Evaluation standard of curative effect of distal radius fracture
And (3) curing: the fracture is aligned satisfactorily, continuous callus formation is caused, local deformity is not obvious, pain and swelling are avoided, the function is completely or basically recovered, or the wrist and palm bending, dorsal extension and forearm rotation are limited within 15 degrees.
Improvement: poor fracture alignment, mild local pain, mild deformity, limited rotation of the wrist, the back, the palm and the forearm within 45 degrees.
The disease is not cured: fracture nonunion or deformity healing, tenderness, percussion pain, dysfunction.
(5) Wrist joint function rehabilitation condition evaluation method
The time to pain relief, the degree of swelling of the patients were recorded and the wrist joint function was compared. Pain was assessed using a VAS pain score and swelling was assessed using a fractional score of fracture swelling. Wrist function was assessed using the cooney wrist score, which is given in table 1.
TABLE 1 cooney wrist score criteria
(6) Statistical method
Statistical analysis was performed using SPSS21.0 software, data were described in terms of percentage (%) for the rank and goodness of wrist function, and the incidence of complications was determined by X2 test against the spread scale, with P < 0.05 representing a statistical difference between groups.
2. Results of the experiment
(1) The treatment effect of the patients with distal radius fracture in the control group and the observation group is shown in table 2.
TABLE 2 comparison of the effects of the groups on the treatment of distal radius fractures
| Total number of tested persons | The number of people cured | Number of good turning people | The number of unhealed people | Total effective rate | |
| Observation group | 100 | 52 | 38 | 10 | 90 |
| Control group | 100 | 48 | 33 | 19 | 81 |
The total effective rate is (number of healed people + number of improved people)/total number of tested people x 100%
The results show that the prepared pepper-fragrance cold-dispelling pain-relieving fumigation and washing formula can effectively treat distal radius fracture, the total effective rate is up to 90%, and the treatment effect is remarkably superior to that of a control group.
(2) The rehabilitation of the wrist joint function of the patients in the control group and the observation group is shown in Table 3.
TABLE 3 comparison of the rehabilitation status of wrist joint function for each group of patients
Excellence rate ═ excellence number + "good" number)/total number of subjects × 100%
The result shows that the prepared pepper-fragrance cold-dispelling pain-relieving fumigation and washing method can effectively promote the rehabilitation of the wrist joint function of the patient with the distal radius fracture (the excellent rate is up to 90%), and has an excellent treatment effect on the wrist joint dysfunction after the distal radius fracture.
In conclusion, the invention provides a traditional Chinese medicine composition consisting of 5 raw material medicines of pepper, fennel, rhizoma atractylodis, green tangerine peel and cinnamon. The experimental result shows that the traditional Chinese medicine composition can effectively treat distal radius fracture, and the total effective rate is up to 90%; the traditional Chinese medicine composition can also effectively promote the rehabilitation of the wrist joint function of a patient with distal radius fracture (the excellent rate is up to 90%), and has an excellent treatment effect on wrist joint dysfunction caused by distal radius fracture. Therefore, the traditional Chinese medicine composition has wide application prospect in preparing medicines for treating fractures (especially distal radius fractures) and medicines for treating joint dysfunction (especially wrist joint dysfunction caused by distal radius fractures).
Claims (10)
1. A traditional Chinese medicine composition is characterized in that: the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 90-110 parts of pepper, 20-40 parts of fennel, 10-20 parts of rhizoma atractylodis, 10-20 parts of green tangerine peel and 3-8 parts of cinnamon.
2. The traditional Chinese medicine composition according to claim 1, characterized in that: the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 100 parts of pepper, 30 parts of fennel, 15 parts of rhizoma atractylodis, 15 parts of green tangerine peel and 5 parts of cinnamon.
3. The method for preparing the traditional Chinese medicine composition of any one of claims 1 to 2, which is characterized in that: the method comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) preparing medicinal powder of raw materials, and water extract or organic solvent extract of raw materials.
4. The method according to claim 3, wherein: the preparation method of the water extract of the raw material medicines comprises the following steps: decocting the raw materials in water, collecting aromatic water and decoction, and concentrating or drying; wherein the aromatic water is mixture of volatile oil and water vapor distilled during decoction; the decoction is the filtrate left after decoction and filtration;
preferably, the decocting times are 1-2 times, the weight of water added in each time is 2-3 times of the weight of the raw material medicine, and the decocting time is 0.5-1 hour.
5. A medicament for treating bone fracture, which is characterized in that: the medicine is a preparation prepared by taking the traditional Chinese medicine composition as an active ingredient according to any one of claims 1-2 and adding pharmaceutically acceptable auxiliary materials.
6. The medicament of claim 5, wherein: the preparation is an external preparation.
7. The medicament of claim 6, wherein: the external preparation is fumigant, lotion, fumigation lotion, application, liniment, patch or drop, preferably fumigation lotion.
8. Use of the Chinese medicinal composition of any one of claims 1-2 for the preparation of a medicament for the treatment of bone fracture, preferably, the bone fracture is distal radius fracture.
9. Use of a Chinese medicinal composition according to any one of claims 1-2 for the preparation of a medicament for the treatment of joint dysfunction, preferably, the joint dysfunction is finger joint dysfunction, wrist joint dysfunction, shoulder joint dysfunction or elbow joint dysfunction.
10. Use according to claim 9, characterized in that: the joint dysfunction is wrist joint dysfunction caused by distal radius fracture.
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- 2020-09-28 CN CN202011043010.5A patent/CN112076261A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 张玉昌: "花椒水对骨折的好处", 《HTTPS://WWW.YOULAI.CN/ASK/BE2530G04LU.HTML》 * |
| 薛磊: "《巧用小偏方 治病一本通》", 31 May 2015, 天津科学技术出版社 * |
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