CN112076124A - Agilawood toothpaste and preparation method thereof - Google Patents
Agilawood toothpaste and preparation method thereof Download PDFInfo
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Abstract
The invention provides agilawood toothpaste which comprises the following raw materials in parts by weight: 40-60 parts of sorbitol, 2-5 parts of PEG-400, 5-15 parts of glycerol, 0.3-0.9 part of agilawood extract, 0.2-0.7 part of carboxymethyl cellulose, 0.2-0.8 part of xanthan gum, 0.5-2 parts of sodium lauroyl sarcosinate, 0.5-2 parts of sodium dodecyl sulfate, 10-30 parts of silicon dioxide comprehensive type, 3-12 parts of silicon dioxide high-abrasion type, 0.1-0.5 part of titanium dioxide, 0.2-0.7 part of menthol, 0.1 part of cooling agent WS-230.02, 30.02-0.1 part of cooling agent WS-30, 07-0.5 part of stevia rebaudiana extract, 0.1-0.6 part of potassium sorbate and 3-8 parts of deionized water; the toothpaste is prepared by the specific process, specific parameters such as temperature, time, stirring speed and the like are limited, the step-by-step operation is carried out, the mixing effect of the toothpaste raw materials is ensured, the use characteristics of all the raw materials are kept, and the quality of the toothpaste is improved, so that better health-care and auxiliary treatment effects are achieved.
Description
Technical Field
The invention relates to the technical field of daily necessities, in particular to agilawood toothpaste and a preparation method thereof.
Background
The toothpaste is a common daily living article, has a long history, new products are continuously appeared along with the development of science and technology, the variety and the variety of the toothpaste are increasingly diversified, the existing toothpaste is not a single clean toothpaste, and the current production method of the toothpaste is mature and is prepared by adding a proper amount of auxiliary materials into a matrix. In order to prepare the toothpaste with health care and treatment effects, most of auxiliary materials are usually added, and the generated toothpaste has poor health care effect and is difficult to effectively solve the oral problems of alleviating oral ulcer, mucosal injury, gingival inflammation bleeding, gingival inflammation and swelling pain, gingival atrophy, wisdom tooth inflammation and the like.
Disclosure of Invention
In view of this, the invention provides agilawood toothpaste and a preparation method thereof, and solves the problems.
The technical scheme of the invention is realized as follows: an agilawood toothpaste is prepared by the following steps: the feed comprises the following raw materials in parts by weight: 40-60 parts of sorbitol, 2-5 parts of PEG-400, 5-15 parts of glycerol, 0.3-0.9 part of agilawood extract, 0.2-0.7 part of carboxymethyl cellulose, 0.2-0.8 part of xanthan gum, 0.5-2 parts of sodium lauroyl sarcosinate, 0.5-2 parts of sodium dodecyl sulfate, 10-30 parts of silicon dioxide comprehensive type, 3-12 parts of silicon dioxide high-abrasion type, 0.1-0.5 part of titanium dioxide, 0.2-0.7 part of menthol, 0.1 part of cooling agent WS-230.02, 30.02-0.1 part of cooling agent WS-30, 07-0.5 part of stevia rebaudiana extract, 0.1-0.6 part of potassium sorbate and 3-8 parts of deionized water.
Preferably, the agilawood toothpaste comprises the following raw materials in parts by weight: 50 parts of sorbitol, 3 parts of PEG-4003 parts of glycerol, 0.6 part of agilawood extract, 0.5 part of carboxymethylcellulose, 0.5 part of xanthan gum, 1.3 parts of sodium lauroyl sarcosinate, 1.5 parts of sodium dodecyl sulfate, 20 parts of silicon dioxide comprehensive type, 7 parts of silicon dioxide high-abrasion type, 0.3 part of titanium dioxide, 0.4 part of menthol, WS-230.06 parts of cooling agent, 30.06 parts of cooling agent WS-30.06 parts of stevia rebaudiana extract, 0.3 part of potassium sorbate and 5 parts of deionized water.
Preferably, the silicon dioxide is synthesized to have a volatile matter content of less than or equal to 10% at 105 ℃, a total salt content of less than or equal to 2.0%, a whiteness of more than or equal to 96%, a water absorption capacity of 30-42 mL/20g, and a silicon dioxide content of more than or equal to 96%.
Preferably, the high-abrasion type of the silicon dioxide is that volatile matters are less than or equal to 10 percent at 105 ℃, total salt is less than or equal to 2.0 percent, whiteness is more than or equal to 93 percent, water absorption is less than 30mL/20g, and the content of the silicon dioxide is more than or equal to 96 percent.
Further, the agilawood extracting solution is prepared by performing freeze drying treatment on agarwood at-20 to-10 ℃, crushing to obtain agilawood sawdust, performing subcritical extraction by using propane as a subcritical fluid extractant, wherein the extraction pressure is 0.2 to 0.6MPa, the extraction temperature is 65 to 87 ℃, the extraction time is 1 to 3 hours, and taking an extraction liquid as the agilawood extracting solution.
Further, the stevia rebaudiana extractive solution is obtained by performing reflux extraction on dried leaves of stevia rebaudiana with 50-90% of ethanol for 1-3 times, 40-80 min each time, and recovering a solvent.
Further, the preparation method of the agilawood toothpaste comprises the following steps:
s1, adding water, glycerin, carboxymethyl cellulose, xanthan gum, silicon dioxide, titanium dioxide, sodium lauroyl sarcosinate and sodium dodecyl sulfate into an emulsifying device, heating to 60-80 ℃, stirring for 30-40 min;
s2, continuously heating the mixed materials to 90-110 ℃, adding agilawood extracting solution and stevia rebaudiana extracting solution, continuously stirring uniformly for 15-30 min, and filtering;
s3, cooling the mixture of S2 to 40-50 ℃, adding menthol, cooling agent WS-23, cooling agent WS-3 and potassium sorbate, uniformly stirring, grinding and vacuum degassing to obtain the agilawood toothpaste body.
Preferably, the stirring speed of S1 is 80-100 rpm.
Preferably, the stirring speed of the S2 is 120-200 rpm.
Compared with the prior art, the invention has the beneficial effects that:
the agilawood toothpaste disclosed by the invention is scientifically selected and reasonably proportioned, so that the agilawood toothpaste has health care and auxiliary treatment functions, can eliminate peculiar smell in the oral cavity, has a good antibacterial effect, inhibits bacterial breeding, reduces oral problems such as oral ulcer, mucosal injury, gingival inflammation and swelling and pain, and also has health care effects of protecting and strengthening teeth; the Chinese medicinal composition is compounded by the agilawood extract and the stevia rebaudiana extract, has the effects of promoting qi circulation, relieving pain, warming middle energizer, stopping vomiting, promoting inspiration, relieving asthma, dredging collaterals, lowering qi and the like, plays a certain role in the benign operation of the functions of the heart, the liver, the intestines and the stomach and the like of people, and can achieve better effects of diminishing inflammation, relieving pain, inhibiting dental ulcer, assisting in treating periodontitis, sore throat and the like by being matched with other raw materials; the toothpaste is prepared by the specific process, specific parameters such as temperature, time, stirring speed and the like are limited, the step-by-step operation is carried out, the mixing effect of the toothpaste raw materials is ensured, the use characteristics of all the raw materials are kept, and the quality of the toothpaste is improved, so that better health-care and auxiliary treatment effects are achieved.
Detailed Description
In order to better understand the technical content of the invention, specific examples are provided below to further illustrate the invention.
The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.
The materials, reagents and the like used in the examples of the present invention can be obtained commercially without specific description.
Example 1
An agilawood toothpaste is prepared by the following steps: the feed comprises the following raw materials in parts by weight: 40 parts of sorbitol, 2 parts of PEG-4002 parts of glycerol, 0.3 part of agilawood extract, 0.2 part of carboxymethylcellulose, 0.2 part of xanthan gum, 0.5 part of sodium lauroyl sarcosinate, 0.5 part of sodium dodecyl sulfate, 10 parts of silicon dioxide comprehensive type, 3 parts of silicon dioxide high-abrasion type, 0.1 part of titanium dioxide, 0.2 part of menthol, WS-230.02 parts of cooling agent, 30.02 parts of cooling agent WS-30.02 parts of stevia rebaudiana extract, 0.07 part of potassium sorbate and 3 parts of deionized water.
The agilawood extracting solution is prepared by performing freeze drying treatment on agarwood at-20 ℃, crushing to obtain agilawood sawdust, performing subcritical extraction by using propane as a subcritical fluid extracting agent, wherein the extraction pressure is 0.2MPa, the extraction temperature is 65 ℃, the extraction time is 1h, and the extract liquid is taken as the agilawood extracting solution.
The sweet stevia extractive solution is prepared by extracting dry leaves of sweet stevia with 50% ethanol under reflux for 1 time, 40min each time, and recovering solvent to obtain sweet stevia extractive solution.
Example 2
An agilawood toothpaste is prepared by the following steps: the feed comprises the following raw materials in parts by weight: 60 parts of sorbitol, 5 parts of PEG-4005 parts of glycerol, 0.9 part of agilawood extract, 0.7 part of carboxymethylcellulose, 0.8 part of xanthan gum, 2 parts of sodium lauroyl sarcosinate, 2 parts of sodium dodecyl sulfate, 30 parts of silicon dioxide comprehensive type, 12 parts of silicon dioxide high-abrasion type, 0.5 part of titanium dioxide, 0.7 part of menthol, WS-230.1 parts of cooling agent, 30.1 parts of cooling agent, 0.5 part of stevia rebaudiana extract, 0.6 part of potassium sorbate and 8 parts of deionized water.
The agilawood extracting solution is prepared by performing freeze drying treatment on agarwood at-10 ℃, crushing to obtain agilawood sawdust, performing subcritical extraction by using propane as a subcritical fluid extracting agent, wherein the extraction pressure is 0.6MPa, the extraction temperature is 87 ℃, the extraction time is 3 hours, and the extract liquid is taken as the agilawood extracting solution.
The sweet stevia extractive solution is prepared by extracting dry leaves of sweet stevia with 90% ethanol under reflux for 3 times, each time for 80min, and recovering solvent to obtain sweet stevia extractive solution.
Example 3
The agilawood toothpaste comprises the following raw materials in parts by weight: 50 parts of sorbitol, 3 parts of PEG-4003 parts of glycerol, 0.6 part of agilawood extract, 0.5 part of carboxymethylcellulose, 0.5 part of xanthan gum, 1.3 parts of sodium lauroyl sarcosinate, 1.5 parts of sodium dodecyl sulfate, 20 parts of silicon dioxide comprehensive type, 7 parts of silicon dioxide high-abrasion type, 0.3 part of titanium dioxide, 0.4 part of menthol, WS-230.06 parts of cooling agent, 30.06 parts of cooling agent WS-30.06 parts of stevia rebaudiana extract, 0.3 part of potassium sorbate and 5 parts of deionized water.
The agilawood extracting solution is prepared by performing freeze drying treatment on agarwood at-15 ℃, crushing to obtain agilawood sawdust, performing subcritical extraction by using propane as a subcritical fluid extracting agent, wherein the extraction pressure is 0.4MPa, the extraction temperature is 75 ℃, the extraction time is 2 hours, and the extract liquid is taken as the agilawood extracting solution.
The sweet stevia extractive solution is prepared by extracting dry leaves of sweet stevia with 70% ethanol under reflux for 2 times, each time for 60min, and recovering solvent to obtain sweet stevia extractive solution.
The following preparation methods were used in the above examples 1 to 3:
s1, adding water, glycerol, carboxymethyl cellulose, xanthan gum, silicon dioxide, titanium dioxide, sodium lauroyl sarcosinate and sodium dodecyl sulfate into an emulsifying device, heating to 60-80 ℃, stirring at a stirring speed of 90rpm for 35 min;
s2, continuously heating the mixed materials to 100 ℃, adding agilawood extracting solution and stevia rebaudiana extracting solution, continuously and uniformly stirring at the stirring speed of 160rpm for 18min, and filtering;
s3, cooling the mixed material of S2 to 45 ℃, adding menthol, cooling agent WS-23, cooling agent WS-3 and potassium sorbate, uniformly stirring, grinding and vacuum degassing to obtain the agilawood toothpaste body.
Example 4
The difference between the embodiment and the embodiment 3 is that the agilawood toothpaste comprises the following preparation methods:
s1, adding water, glycerol, carboxymethyl cellulose, xanthan gum, silicon dioxide, titanium dioxide, sodium lauroyl sarcosinate and sodium dodecyl sulfate into an emulsifying device, heating to 60 ℃, stirring at a stirring speed of 80rpm for 30 min;
s2, continuously heating the mixed materials to 90 ℃, adding agilawood extracting solution and stevia rebaudiana extracting solution, continuously and uniformly stirring at the stirring speed of 120rpm for 15min, and filtering;
s3, cooling the mixed material of S2 to 40 ℃, adding menthol, cooling agent WS-23, cooling agent WS-3 and potassium sorbate, uniformly stirring, grinding and vacuum degassing to obtain the agilawood toothpaste body.
Example 5
The difference between the embodiment and the embodiment 3 is that the agilawood toothpaste comprises the following preparation methods:
s1, adding water, glycerol, carboxymethyl cellulose, xanthan gum, silicon dioxide, titanium dioxide, sodium lauroyl sarcosinate and sodium dodecyl sulfate into an emulsifying device, heating to 80 ℃, stirring at a stirring speed of 100rpm for 40 min;
s2, continuously heating the mixed materials to 110 ℃, adding agilawood extracting solution and stevia rebaudiana extracting solution, continuously and uniformly stirring at the stirring speed of 200rpm for 30min, and filtering;
s3, cooling the mixed material of S2 to 50 ℃, adding menthol, cooling agent WS-23, cooling agent WS-3 and potassium sorbate, uniformly stirring, grinding and vacuum degassing to obtain the agilawood toothpaste body.
Comparative example 1
The difference between this comparative example and example 3 is that an agilawood toothpaste: the feed comprises the following raw materials in parts by weight: 30 parts of sorbitol, 6 parts of PEG-4006 parts of glycerol, 20 parts of agilawood extract, 1.0 part of carboxymethylcellulose, 0.1 part of xanthan gum, 1.2 parts of sodium lauroyl sarcosinate, 0.2 part of sodium dodecyl sulfate, 40 parts of silicon dioxide comprehensive type, 2 parts of silicon dioxide high-abrasion type, 0.6 part of titanium dioxide, 0.1 part of menthol, WS-230.5 parts of cooling agent, 30.3 parts of cooling agent WS-30.3 parts of stevia rebaudiana extract, 0.05 part of potassium sorbate and 2 parts of deionized water.
Comparative example 2
The difference between this comparative example and example 3 is that an agilawood toothpaste: the feed comprises the following raw materials in parts by weight: 30 parts of sorbitol, 6 parts of PEG-4006 parts of glycerol, 20 parts of agilawood extract, 1.0 part of carboxymethylcellulose, 0.1 part of xanthan gum, 1.2 parts of sodium lauroyl sarcosinate, 0.2 part of sodium dodecyl sulfate, 40 parts of silicon dioxide comprehensive type, 2 parts of silicon dioxide high-abrasion type, 0.3 part of titanium dioxide, 0.4 part of menthol, WS-230.06 parts of cooling agent, 30.06 parts of cooling agent WS-30.06 parts of stevia rebaudiana extract, 0.3 part of potassium sorbate and 5 parts of deionized water.
Comparative example 3
The difference between this comparative example and example 3 is that an agilawood toothpaste: the feed comprises the following raw materials in parts by weight: 50 parts of sorbitol, 3 parts of PEG-4003 parts of glycerol, 0.6 part of agilawood extract, 0.5 part of carboxymethylcellulose, 0.5 part of xanthan gum, 1.3 parts of sodium lauroyl sarcosinate, 1.5 parts of sodium dodecyl sulfate, 20 parts of silicon dioxide comprehensive type, 7 parts of silicon dioxide high-abrasion type, 0.6 part of titanium dioxide, 0.1 part of menthol, WS-230.5 parts of cooling agent, 30.3 parts of cooling agent WS-30.3 parts of stevia rebaudiana extract, 0.05 part of potassium sorbate and 2 parts of deionized water.
Efficacy test of agilawood toothpaste
(I) bacteriostatic test
The toothpaste formulas of examples 1-5 and comparative examples 1-3 are adopted to carry out bacteriostatic tests, and the test results are as follows:
as can be seen from the above table, the agilawood toothpaste disclosed by the invention has a strong antibacterial effect on escherichia coli, staphylococcus aureus, candida albicans and streptococcus mutans, wherein the antibacterial effect of the example 3 is the best.
(II) clinical test for healing of oral ulcer
1. Subject: 160 patients with recurrent aphthous stomatitis were selected and randomized into 8 groups of 20.
2. The test method comprises the following steps: the teeth are brushed after three meals every day for 2 months.
3. Evaluation criteria:
(1) the effect is shown: the ulcer area disappears by more than 90%, the repair period is shortened by 1-2 days, the number of ulcers is reduced, and the swelling and aching of gum are improved.
(2) The method has the following advantages: the ulcer area disappears by 30-90%, the repair period is shortened by 2-5 days, the number of ulcers is unchanged, and the swelling and aching of gum are improved.
(3) And (4) invalidation: the ulcer area disappears within 30 percent, the repair period is shortened and unchanged, the ulcer quantity is unchanged, and the swelling and aching of gum are unchanged.
4. Results of Effect test
As can be seen from the above table, compared with the examples 1-5 and the comparative examples 1-3, the agilawood toothpaste disclosed by the invention has the advantages that the used raw materials and the used proportion can effectively shorten the ulcer period, reduce oral inflammation, accelerate the healing of oral ulcer and reduce ulcer pain, and has obvious effects.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (9)
1. An agilawood toothpaste is characterized in that: the feed comprises the following raw materials in parts by weight: 40-60 parts of sorbitol, 2-5 parts of PEG-400, 5-15 parts of glycerol, 0.3-0.9 part of agilawood extract, 0.2-0.7 part of carboxymethyl cellulose, 0.2-0.8 part of xanthan gum, 0.5-2 parts of sodium lauroyl sarcosinate, 0.5-2 parts of sodium dodecyl sulfate, 10-30 parts of silicon dioxide comprehensive type, 3-12 parts of silicon dioxide high-abrasion type, 0.1-0.5 part of titanium dioxide, 0.2-0.7 part of menthol, 0.1 part of cooling agent WS-230.02, 30.02-0.1 part of cooling agent WS-30, 07-0.5 part of stevia rebaudiana extract, 0.1-0.6 part of potassium sorbate and 3-8 parts of deionized water.
2. The agilawood toothpaste according to claim 1, wherein: the feed comprises the following raw materials in parts by weight: 50 parts of sorbitol, 3 parts of PEG-4003 parts of glycerol, 0.6 part of agilawood extract, 0.5 part of carboxymethylcellulose, 0.5 part of xanthan gum, 1.3 parts of sodium lauroyl sarcosinate, 1.5 parts of sodium dodecyl sulfate, 20 parts of silicon dioxide comprehensive type, 7 parts of silicon dioxide high-abrasion type, 0.3 part of titanium dioxide, 0.4 part of menthol, WS-230.06 parts of cooling agent, 30.06 parts of cooling agent WS-30.06 parts of stevia rebaudiana extract, 0.3 part of potassium sorbate and 5 parts of deionized water.
3. The agilawood toothpaste according to claim 1, wherein: the silicon dioxide comprehensive type is that volatile matters at 105 ℃ are less than or equal to 10%, total salt is less than or equal to 2.0%, whiteness is greater than or equal to 96%, water absorption capacity is 30-42 mL/20g, and silicon dioxide content is greater than or equal to 96%.
4. The agilawood toothpaste according to claim 1, wherein: the high-abrasion type of the silicon dioxide is that volatile matters at 105 ℃ are less than or equal to 10 percent, total salt is less than or equal to 2.0 percent, whiteness is more than or equal to 93 percent, water absorption is less than 30mL/20g, and the content of the silicon dioxide is more than or equal to 96 percent.
5. The agilawood toothpaste according to claim 1, wherein: the agilawood extracting solution is prepared by performing freeze drying treatment on agarwood at-20 to-10 ℃, crushing to obtain agilawood sawdust, performing subcritical extraction by using propane as a subcritical fluid extracting agent, wherein the extraction pressure is 0.2 to 0.6MPa, the extraction temperature is 65 to 87 ℃, the extraction time is 1 to 3 hours, and extracting liquid is taken as agilawood extracting solution.
6. The agilawood toothpaste according to claim 1, wherein: the stevia rebaudiana extractive solution is obtained by performing reflux extraction on dried stevia rebaudiana leaves by using 50-90% by volume of ethanol for 1-3 times, 40-80 min each time, and recovering a solvent.
7. The preparation method of agilawood toothpaste as claimed in claim 1, wherein the preparation method comprises the following steps: the method comprises the following steps:
s1, adding water, glycerin, carboxymethyl cellulose, xanthan gum, silicon dioxide, titanium dioxide, sodium lauroyl sarcosinate and sodium dodecyl sulfate into an emulsifying device, heating to 60-80 ℃, stirring for 30-40 min;
s2, continuously heating the mixed materials to 90-110 ℃, adding agilawood extracting solution and stevia rebaudiana extracting solution, continuously stirring uniformly for 15-30 min, and filtering;
s3, cooling the mixture of S2 to 40-50 ℃, adding menthol, cooling agent WS-23, cooling agent WS-3 and potassium sorbate, uniformly stirring, grinding and vacuum degassing to obtain the agilawood toothpaste body.
8. The preparation method of agilawood toothpaste as claimed in claim 7, wherein the preparation method comprises the following steps: the stirring speed of the S1 is 80-100 rpm.
9. The preparation method of agilawood toothpaste as claimed in claim 7, wherein the preparation method comprises the following steps: the stirring speed of the S2 is 120-200 rpm.
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| CN117323241A (en) * | 2023-10-24 | 2024-01-02 | 金三江(肇庆)硅材料股份有限公司 | Silica particles for oral cavity as well as preparation method and application thereof |
| CN117323241B (en) * | 2023-10-24 | 2024-05-28 | 金三江(肇庆)硅材料股份有限公司 | Silica particles for oral cavity as well as preparation method and application thereof |
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