CN112074523A - 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的化合物 - Google Patents
作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的化合物 Download PDFInfo
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- CN112074523A CN112074523A CN201980030142.3A CN201980030142A CN112074523A CN 112074523 A CN112074523 A CN 112074523A CN 201980030142 A CN201980030142 A CN 201980030142A CN 112074523 A CN112074523 A CN 112074523A
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- pyridin
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- thiadiazol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明属于化学药物技术领域，特别提供了一系列作为用于治疗血小板聚集的蛋白酶激活受体4(PAR4)抑制剂的化合物及其医药用途。
Description
PCT国内申请，说明书已公开。
Claims (12)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018104692781 | 2018-05-16 | ||
| CN201810469278 | 2018-05-16 | ||
| PCT/CN2019/086556 WO2019218955A1 (zh) | 2018-05-16 | 2019-05-13 | 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112074523A true CN112074523A (zh) | 2020-12-11 |
| CN112074523B CN112074523B (zh) | 2022-08-09 |
Family
ID=68539522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980030142.3A Active CN112074523B (zh) | 2018-05-16 | 2019-05-13 | 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的化合物 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN112074523B (zh) |
| WO (1) | WO2019218955A1 (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104540835A (zh) * | 2012-04-26 | 2015-04-22 | 百时美施贵宝公司 | 用于治疗血小板聚集的作为蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑衍生物 |
| CN104640869A (zh) * | 2012-04-26 | 2015-05-20 | 百时美施贵宝公司 | 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑和咪唑并哒嗪衍生物 |
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2019
- 2019-05-13 CN CN201980030142.3A patent/CN112074523B/zh active Active
- 2019-05-13 WO PCT/CN2019/086556 patent/WO2019218955A1/zh active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104540835A (zh) * | 2012-04-26 | 2015-04-22 | 百时美施贵宝公司 | 用于治疗血小板聚集的作为蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑衍生物 |
| CN104640869A (zh) * | 2012-04-26 | 2015-05-20 | 百时美施贵宝公司 | 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑和咪唑并哒嗪衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112074523B (zh) | 2022-08-09 |
| WO2019218955A1 (zh) | 2019-11-21 |
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|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: Area A, 4th Floor, Digital Peninsula, No. 2, Hongliu Road, Fubao Community, Fubao Street, Futian District, Shenzhen, Guangdong, 518017 Patentee after: SHENZHEN SALUBRIS PHARMACEUTICALS Co.,Ltd. Address before: 518040 37th floor, chegongmiao Lvjing Plaza, 6009 Shennan Avenue, Futian District, Shenzhen City, Guangdong Province Patentee before: SHENZHEN SALUBRIS PHARMACEUTICALS Co.,Ltd. |