CN112057613A - MERS-CoV疫苗 - Google Patents

MERS-CoV疫苗 Download PDF

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Publication number
CN112057613A
CN112057613A CN202010825164.3A CN202010825164A CN112057613A CN 112057613 A CN112057613 A CN 112057613A CN 202010825164 A CN202010825164 A CN 202010825164A CN 112057613 A CN112057613 A CN 112057613A
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CN
China
Prior art keywords
mers
seq
spike
ser
cov
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010825164.3A
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English (en)
Chinese (zh)
Inventor
大卫·B·韦纳
卡鲁皮亚·穆苏马尼
尼兰詹·Y·萨尔德赛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ainuo Pharmaceutical Co ltd
University of Pennsylvania Penn
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Ainuo Pharmaceutical Co ltd
University of Pennsylvania Penn
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Filing date
Publication date
Application filed by Ainuo Pharmaceutical Co ltd, University of Pennsylvania Penn filed Critical Ainuo Pharmaceutical Co ltd
Publication of CN112057613A publication Critical patent/CN112057613A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/215Coronaviridae, e.g. avian infectious bronchitis virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/20011Coronaviridae
    • C12N2770/20034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202010825164.3A 2013-11-29 2014-11-26 MERS-CoV疫苗 Pending CN112057613A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361910153P 2013-11-29 2013-11-29
US61/910,153 2013-11-29
CN201480074433.XA CN105939730B (zh) 2013-11-29 2014-11-26 MERS-CoV疫苗

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480074433.XA Division CN105939730B (zh) 2013-11-29 2014-11-26 MERS-CoV疫苗

Publications (1)

Publication Number Publication Date
CN112057613A true CN112057613A (zh) 2020-12-11

Family

ID=53199622

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202010825164.3A Pending CN112057613A (zh) 2013-11-29 2014-11-26 MERS-CoV疫苗
CN201480074433.XA Active CN105939730B (zh) 2013-11-29 2014-11-26 MERS-CoV疫苗

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201480074433.XA Active CN105939730B (zh) 2013-11-29 2014-11-26 MERS-CoV疫苗

Country Status (10)

Country Link
US (5) US10016497B2 (https=)
EP (1) EP3074051A4 (https=)
JP (1) JP6412131B2 (https=)
KR (2) KR20160091350A (https=)
CN (2) CN112057613A (https=)
AU (1) AU2014354797C1 (https=)
CA (1) CA2932055A1 (https=)
IL (3) IL276210B2 (https=)
SA (1) SA516371223B1 (https=)
WO (1) WO2015081155A1 (https=)

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US11103575B2 (en) 2014-02-28 2021-08-31 The New York Blood Center, Inc. Immunogenic composition for MERS coronavirus infection
EP3045181B1 (en) * 2015-01-19 2018-11-14 Ludwig-Maximilians-Universität München A novel vaccine against the middle east respiratory syndrome coronavirus (MERS-CoV)
US11058779B2 (en) 2015-09-08 2021-07-13 Sirnaomics, Inc. Sirna/nanoparticle formulations for treatment of middle-east respiratory syndrome coronaviral infection
TW201729835A (zh) * 2015-10-22 2017-09-01 現代公司 呼吸道病毒疫苗
CN106397549B (zh) * 2016-10-11 2019-08-06 中国疾病预防控制中心病毒病预防控制所 MERS-CoV特异性多肽及其应用
WO2018089306A1 (en) 2016-11-10 2018-05-17 Oyagen, Inc. Methods of treating and inhibiting ebola virus infection
WO2018097603A2 (ko) * 2016-11-23 2018-05-31 에스케이케미칼 주식회사 중동호흡기증후군 코로나바이러스 s 단백질 면역원 조성물 및 이의 제작 방법
MA47790A (fr) 2017-03-17 2021-05-05 Modernatx Inc Vaccins à base d'arn contre des maladies zoonotiques
WO2019078600A1 (ko) * 2017-10-19 2019-04-25 (주)에이티젠 중동호흡기증후군 코로나바이러스에 대한 항체 및 이를 이용한 항체역가 측정방법
US11738025B2 (en) 2020-02-04 2023-08-29 Oyagen, Inc. Method for treating coronavirus infections
CN115867349A (zh) 2020-02-25 2023-03-28 艾诺奥医药品有限公司 针对冠状病毒的疫苗和使用方法
CN111378785A (zh) * 2020-03-12 2020-07-07 仁宽(上海)生物科技有限公司 用于核酸诊断新型冠状病毒2019-nCov的假病毒标准品及其应用
US11559577B2 (en) 2020-03-31 2023-01-24 Engimata, Inc. Immunogenic composition forming a vaccine, and a method for its manufacture
KR102756774B1 (ko) * 2020-05-08 2025-01-21 한림대학교 산학협력단 코로나 바이러스 억제용 펩타이드 및 그 용도
JP2023525552A (ja) * 2020-05-12 2023-06-16 グレフェックス, インコーポレイテッド ワクチン抗原としてのコロナウイルススパイクタンパク質の操作、その設計及び使用
US20230210981A1 (en) * 2020-06-09 2023-07-06 The Wistar Institute Of Anatomy And Biology Coronavirus disease 2019 (covid-19) combination vaccine
WO2022011332A2 (en) * 2020-07-10 2022-01-13 Engimata, Inc Immunogenic composition forming a vaccine, and a method for its manufacture
WO2022020604A1 (en) * 2020-07-22 2022-01-27 Greffex, Inc. Multivalent beta-coronavirus vaccines, their design and uses
JPWO2022025029A1 (https=) * 2020-07-27 2022-02-03
UY39378A (es) * 2020-08-14 2022-01-31 Univ Wuerzburg J Maximilians Vacuna de salmonella para el tratamiento de coronavirus
WO2022046737A1 (en) * 2020-08-25 2022-03-03 The Wistar Institute Of Anatomy And Biology Intradermal mers-cov vaccine
WO2022051816A1 (en) * 2020-09-10 2022-03-17 The Council Of The Queensland Institute Of Medical Research Methods of determining immune response
EP4210724A4 (en) * 2020-09-11 2024-10-02 Memgen, Inc. INCREASING IMMUNITY WITH CHIMERIC CD40 LIGAND AND CORONAVIRUS VACCINE
US20220370598A1 (en) * 2021-05-05 2022-11-24 Inovio Pharmaceuticals, Inc. Vaccines Against Coronavirus and Methods of Use

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CN101076591A (zh) * 2004-07-21 2007-11-21 香港大学 一种引起呼吸道感染的新型人病毒及其用途
CN105939730A (zh) * 2013-11-29 2016-09-14 宾夕法尼亚大学理事会 MERS-CoV疫苗

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Also Published As

Publication number Publication date
CN105939730A (zh) 2016-09-14
IL276210B2 (en) 2024-01-01
US20190022213A1 (en) 2019-01-24
WO2015081155A1 (en) 2015-06-04
IL245903A0 (en) 2016-07-31
US11801298B2 (en) 2023-10-31
AU2014354797A1 (en) 2016-07-07
US20200222527A1 (en) 2020-07-16
AU2014354797C1 (en) 2018-02-01
IL276210A (en) 2020-09-30
SA516371223B1 (ar) 2023-01-31
US11135284B2 (en) 2021-10-05
CN105939730B (zh) 2020-09-11
US10016497B2 (en) 2018-07-10
CA2932055A1 (en) 2015-06-04
EP3074051A1 (en) 2016-10-05
US20170258893A1 (en) 2017-09-14
JP6412131B2 (ja) 2018-10-24
JP2016539946A (ja) 2016-12-22
US10548971B2 (en) 2020-02-04
AU2014354797B2 (en) 2017-10-26
IL276210B1 (en) 2023-09-01
US20240123056A1 (en) 2024-04-18
IL245903B (en) 2020-08-31
KR20160091350A (ko) 2016-08-02
US20210401972A1 (en) 2021-12-30
IL305392A (en) 2023-10-01
KR20230122181A (ko) 2023-08-22
EP3074051A4 (en) 2017-04-12

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