CN112057569A - Traditional Chinese medicine composition for regulating and nourishing qi and blood of women and preparation method thereof - Google Patents
Traditional Chinese medicine composition for regulating and nourishing qi and blood of women and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
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- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The application provides a traditional Chinese medicine composition for regulating and nourishing female qi and blood, which is characterized in that raw materials comprise Chinese yam, gordon euryale seed, fried coix seed, white hyacinth bean, red bean, lotus seed, rhizoma polygonati, longan, black date and wolfberry fruit. The application also provides a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in improving facial skin conditions and/or regulating menstrual disorder.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines and health-care products, and particularly relates to a health-care food containing Chinese yam, gordon euryale seed, fried coix seed, white hyacinth bean, red bean, lotus seed pulp, rhizoma polygonati, longan, black date and wolfberry. The application also provides a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in improving facial skin conditions and/or regulating menstrual disorder.
Background
Due to the gradual increase of modern life and working pressure, and the influence of factors such as long-term staying up all night and emotional tension, the problem of abnormal qi and blood commonly exists in modern women, wherein the abnormal qi and blood comprises different symptoms such as qi stagnation, blood stasis, qi and blood deficiency and the like, and various health problems such as irregular menstruation, dysmenorrhea, dark complexion and the like can be caused. Therefore, the effects of improving the female qi-blood disorder and restoring the female qi-blood circulation are of great significance for maintaining the female health.
The theory of traditional Chinese medicine is profound, and the traditional Chinese medicinal materials are selected from natural animals and plants, have small side effect on human bodies, are mature in application and are favored by people. The traditional Chinese medicine has long-term understanding of female qi and blood disorder, and the Huangdi's internal classic teaches that women have sufficient qi and blood and are healthy and healthy due to the fact that the Huangdi's internal classic proposes that the blood is taken as the basis, and various qi and blood related diseases can be caused if the qi and blood are disharmony. Therefore, regulating qi and blood in women is an important method for treating diseases related to women. Therefore, the research of the traditional Chinese medicine composition for regulating the qi and blood of the women based on the theory of traditional Chinese medicine is an important means for treating the qi and blood disorder diseases such as dull complexion, irregular menstruation, dysmenorrheal and the like of the women.
The traditional medicines for harmonizing qi and blood of women mainly comprise Xiaoyao powder, radix bupleuri liver-soothing powder, Siwu decoction and the like, and have the following problems that the first medicine is a medicine with more application medicines, wherein the medicine property is strong, the price of the medicine is higher, the safety is relatively poor (radix bupleuri, ligusticum chuanxiong hort, rehmannia glutinosa and the like have certain adverse effects and are not suitable for long-term administration), and the application/administration time of the medicine is relatively limited; in addition, the traditional Chinese medicine formulas such as Xiaoyao powder, radix bupleuri powder for soothing the liver, Siwu decoction and the like do not lack medicinal materials with bitter taste and strange flavor, the taste is not good, and the psychological burden and the conflicted mood of patients are increased when the traditional Chinese medicine is taken.
Disclosure of Invention
Therefore, aiming at the problems, the invention provides a traditional Chinese medicine formula for regulating qi and blood of women. The adopted medicines are all traditional Chinese medicine/food raw materials with homology of medicine and food, the medicine is wide in applicable population, good in safety and suitable for female maintenance in daily life; in addition, the lessee combines the traditional classic and modern pharmacological research of the traditional Chinese medicine, simplifies the selected medicines, and reduces the economic burden of patients to the greatest extent while ensuring the curative effect.
Aiming at the problems in the background technology part, the traditional Chinese medicine composition provided by the application takes the components for nourishing liver and kidney and blood and qi as main components and is supplemented with a plurality of drugs for relieving exterior syndrome with pungent and cool natured drugs, inducing diuresis, expelling toxin and calming the nerves, so that good comprehensive curative effect is realized. The invention adopts the following Chinese medicinal components:
the yam is the tuber of dioscorea opposita of the family dioscoreaceae, and is a common food material in China. Has effects of invigorating spleen, tonifying lung, invigorating kidney, and replenishing vital essence. It is indicated for diarrhea due to spleen deficiency, chronic dysentery, cough due to asthenia, diabetes, spermatorrhea, leukorrhagia, and frequent micturition.
Semen euryales is the dried mature kernel of Nymphaeaceae aquatic herbaceous plant semen euryales. Has effects in invigorating kidney, stopping nocturnal emission, invigorating spleen, relieving diarrhea, eliminating dampness, and stopping leukorrhagia. It can be used for treating nocturnal emission, spermatorrhea, enuresis, frequent micturition, spleen deficiency, chronic diarrhea, whitish and turbid urine, and leukorrhagia.
The coix seed is the kernel of the Gramineae plant coix seed, can be eaten by grains, has similar taste to rice, is easy to digest and absorb, can be used as porridge and soup, and is a good medicinal food for patients with weak constitution due to long-term illness and in recovery period after illness, and the old, puerpera and children. Has effects of invigorating spleen, promoting urination, clearing heat away, and relieving cough.
White hyacinth beans, common crops/vegetables, are usually eaten after being dried in the sun and fried. Has the effects of invigorating spleen, eliminating dampness, promoting urination, relieving swelling, removing liver heat, improving eyesight, etc
Red bean, common to crops/vegetables, is commonly used for cooking porridge/soup. Has the effects of inducing diuresis to alleviate edema, removing toxic substance and expelling pus. Can be used for treating edema, tinea pedis, edema, jaundice, dark urine, rheumatism, pyretic arthralgia, carbuncle, suppurative sore, intestinal carbuncle, and abdominal pain.
The lotus pulp is a special name of lotus seeds, is a dry mature seed of lotus of Nymphaeaceae, and has the effects of tonifying spleen, stopping diarrhea, tonifying kidney, arresting seminal emission, nourishing heart and soothing nerves. Can be used for treating spleen deficiency, chronic diarrhea, spermatorrhea, leukorrhagia, palpitation, and insomnia.
Black date, the scientific name of the fruit of the plant black date tree belonging to the family of persimmon trees and the genus Diospyros, is distributed only in northern areas of China. Has effects in invigorating middle warmer, invigorating qi, nourishing blood, tranquilizing mind, and improving eyesight.
Longan, also known as longan, is a common fruit. Has effects in invigorating heart and spleen, and invigorating qi and blood, and can be used for treating insomnia, amnesia, palpitation, and vertigo caused by deficiency of heart and spleen and deficiency of qi and blood.
Rhizoma Polygonati is rhizome of Polygonatum kingianum, Polygonatum sibiricum or Polygonatum cyrtonema of Liliaceae. Has the effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney. Can be used for treating deficiency of spleen-stomach qi, asthenia, stomach yin deficiency, xerostomia, cough with little appetite, lung deficiency, cough with excessive consumption, hemoptysis, essence and blood deficiency, soreness of waist and knees, premature gray hair, and internal heat with thirst quenching effect.
Wolfberry fruit: fructus Lycii is mature fruit of Lycium barbarum L of Solanaceae. Has the effects of nourishing liver and kidney, replenishing vital essence and improving eyesight. Can be used for treating visual deterioration, cataract, blurred vision, soreness of waist and knees, spermatorrhea, deafness, odontoseisis, premature gray hair, insomnia, dreaminess, deficiency of liver-yin and kidney-yin, hectic fever, night sweat, and diabetes due to deficiency of liver-yin and kidney-yin, senilism, and deficiency of essence and blood.
On one hand, the application provides a traditional Chinese medicine composition for regulating and nourishing female qi and blood, which is characterized in that raw materials comprise Chinese yam, gordon euryale seed, fried coix seed, white hyacinth bean, red bean, lotus seed, rhizoma polygonati, longan, black date and wolfberry fruit.
Further, the raw materials comprise, by weight, 20-50 parts of Chinese yam, 20-40 parts of gordon euryale seed, 20-40 parts of fried coix seed, 20-40 parts of white hyacinth bean, 20-40 parts of rice bean, 30-60 parts of lotus seed pulp, 10-30 parts of rhizoma polygonati, 10-30 parts of longan, 20-50 parts of black date and 20-40 parts of wolfberry fruit.
Further, the raw materials comprise 30 parts by weight of Chinese yam, 30 parts by weight of gordon euryale seed, 30 parts by weight of fried coix seed, 30 parts by weight of white hyacinth bean, 30 parts by weight of red bean, 50 parts by weight of lotus seed, 20 parts by weight of rhizoma polygonati, 20 parts by weight of longan, 30 parts by weight of black date and 30 parts by weight of medlar.
Further, the raw materials comprise 30 parts by weight of Chinese yam, 30 parts by weight of gordon euryale seed, 30 parts by weight of fried coix seed, 30 parts by weight of white hyacinth bean, 30 parts by weight of red bean, 50 parts by weight of lotus seed, 20 parts by weight of rhizoma polygonati, 20 parts by weight of longan, 30 parts by weight of black date, 30 parts by weight of medlar, 1500 parts by weight of white spirit and 40 parts by weight of rock candy.
Further, the white spirit is white spirit with 26-degree alcoholic strength.
On the other hand, the application provides a preparation method of the traditional Chinese medicine composition, which is characterized by comprising the steps of soaking mulberries, barbary wolfberry fruits, kudzuvine roots, black beans and Chinese dates in white spirit, and then adding crystal sugar.
Further, the method comprises the steps of:
(1) weighing required medicines, cleaning and then drying;
(2) pulverizing the dried Chinese medicinal materials to 70-100 mesh;
(3) putting the pulverized Chinese medicinal materials into gauze bag to make medicated bag;
(4) immersing the medicine bag obtained in the step (3) into white spirit;
(5) taking out the medicated bag, adding crystal sugar into Chinese liquor, and slightly stirring to melt the crystal sugar.
Further, in the step (4), the medicine bag is immersed in the white spirit for 12-120 hours.
On the other hand, the application provides the application of the traditional Chinese medicine composition in regulating and nourishing qi and blood of women.
Further, regulating qi and blood in women includes improving facial skin condition and/or regulating menstrual disorder.
The traditional Chinese medicine composition of the present application may also contain other traditional Chinese and western medicine components and nutritional supplement components known to have the effects of supplementing nutrition, especially nutrients that women are prone to lack, improving quality of life, improving skin condition, regulating menstrual disorders, including but not limited to various traditional Chinese medicine formulations, Chinese patent medicine products, vitamins, trace element supplements, especially iron supplements, other nutritional supplements, and western medicine components/compounds.
The composition of the present application may be selected from various types according to pharmacopoeia/regulatory authorities, without being limited to a particular type or place of production: for example, wolfberry can be selected from the genuine products produced in Ningxia or other production places; the black date can be selected from products of the origin of Shandong yellow river basin, and can also be selected from other products of the origin; the white spirit can be self-made products or commercial products with various flavor styles, including medicinal liquor, as long as the components in the medicinal liquor have no adverse effect on the effect of the traditional Chinese medicine composition according to the common knowledge in the field of medicine.
The traditional Chinese medicine composition is preferably a medicated wine; in addition, when no white spirit is used, various known traditional Chinese medicines/Chinese patent medicines can be used, especially oral administration dosage forms can be selected by those skilled in the art according to the situation, and include, but are not limited to, decoction, pills, powder, medicinal liquor, paste, troches, tablets, capsules and suspensions.
When necessary for preparing the above dosage forms, those skilled in the art can select suitable adjuvants for the Chinese medicinal composition of the present application according to common general knowledge in pharmacy, including but not limited to solvents, dissolution promoters, stabilizers, antioxidants, thickeners, surfactants, coating agents, dispersants, fillers, etc.
Detailed Description
Example 1 preparation of a Chinese medicinal composition of the present application
Chinese yam, gordon euryale seed, fried coix seed, white hyacinth bean, red bean, lotus seed, rhizoma polygonati, longan, black date, wolfberry fruit and rock candy are qualified products purchased from local medicinal materials and food markets; the white spirit is solid pure good white spirit provided by a cooperation winery, and the alcoholic strength is 26 degrees.
Weighing 30 parts of Chinese yam, 30 parts of gordon euryale seed, 30 parts of fried pearl barley, 30 parts of white hyacinth bean, 30 parts of phaseolus calcaratus, 50 parts of lotus pulp, 20 parts of rhizoma polygonati, 20 parts of longan, 30 parts of black date, 30 parts of wolfberry fruit, 1500 parts of white spirit (corresponding to milliliters in grams) and 40 parts of rock candy;
cleaning and then drying;
pulverizing the dried Chinese medicines to 100 meshes;
putting the pulverized Chinese medicinal materials into gauze bag to make medicated bag;
soaking the obtained medicated bag in Chinese liquor, and standing for 72 hr;
taking out the medicated bag, adding crystal sugar into Chinese liquor, and slightly stirring to melt crystal sugar to obtain composition product (stored in refrigerator as far as possible).
Example 2 evaluation of the quality of Life of the female population by the traditional Chinese medicine composition of the present application
In a cooperative traditional Chinese medicine clinic (the cooperative clinic requires unfair names), 60 women in sub-health state between 35 and 50 years old (the sub-health symptoms such as self-written lassitude, inappetence, dysphoria, irritability and the like, and the sub-health problems such as qi and blood deficiency, kidney deficiency, spleen weakness and the like judged by a clinical traditional Chinese medicine physician without other obvious diseases) are randomly selected:
and (3) inclusion standard: (1) women aged 35-50 years; (2) no long-term outdoor activity or travel plans during the test period; (3) no serious systemic disease and non-allergic constitution; (4) can be performed strictly according to the requirements of the research scheme and signed with an informed consent.
Exclusion criteria: (1) acute inflammation or other skin disorders of the face; (2) pregnant or lactating women; (3) the hormone medicine and the immunosuppressant are used in the last month, and the tested part takes part in other clinical testers at the present or last three months.
Rejection standard: serious adverse reactions occurred during the experiment and the study protocol was not followed.
The influence of the traditional Chinese medicine composition on the health of human bodies is researched by adopting a self-front-back control mode. The intervention mode is that the traditional Chinese medicine composition is taken once a day, 50ml of the traditional Chinese medicine composition is taken after dinner every time, the observation treatment period is 4 weeks, the traditional Chinese medicine symptom scores and European five-dimensional health scale scores (including EQ-5D and EQ-VAS) of the population before and after treatment are observed, and the effective rate of the traditional Chinese medicine composition on improving the body health of the population is observed.
The Chinese medicine symptom scoring items comprise lassitude, weakness, limb numbness, headache, dizziness, inappetence, dysphoria, testiness, waist soreness, lumbago, tongue condition problem and pulse condition problem. Each item was classified into four grades from none to severe, and given a score of 1-4 (when discrimination was insufficient, the score was allowed to be given one digit after the decimal point).
The EQ-5D health description scored on the european five-dimensional health scale includes five dimensions: mobility, ability to care for oneself, ability to do daily activities, pain or discomfort, anxiety or depression. Each project contains three levels: without any, some, or extreme difficulties. The EQ-VAS is a 20 cm vertical visual scale with a top 100 representing the "best health condition in the eye" and a bottom 0 representing the "worst health condition in the eye" (see european society for living and quality website www.quroql.org for details).
The results are as follows:
TABLE 1 comparison of the scores of the symptoms of TCM and the scores of the European five-dimensional health Scale before and after administration
| Item | Before taking | After taking |
| Traditional Chinese medicine symptom scoring | 22.30±3.42 | 14.25±1.87 |
| European five-dimensional health Scale score EQ-5D | 0.624±0.24 | 0.801±0.17 |
| European five-dimensional health Scale score EQ-VAS | 70.69±12.50 | 87.75±14.97 |
The results in table 1 show that the traditional Chinese medicine symptom scores of the population taking the traditional Chinese medicine composition are reduced after the traditional Chinese medicine composition is taken, which shows that the traditional Chinese medicine composition can improve the physical health condition of people from the perspective of traditional Chinese medicine; after the traditional Chinese medicine composition is taken, the EQ-5D and EQ-VAS data scored by the European five-dimensional health scale of the traditional Chinese medicine composition are obviously increased, which shows that the traditional Chinese medicine composition can also improve the physical health condition of female patients and improve the functions of various aspects of the body from the perspective of western medicine.
Example 3 improvement of female facial skin conditions with the Chinese medicinal composition of the present application
The main instruments used were MPA9 multi-probe test system (moisture tester Comeometer CM825, Water loss through the epidermis tester Tewameter TM300, skin oil tester Sebumeter SM815, skin friction tester Fritimeter FR700), skin elasticity tester MPA580, wrinkle analyzer Visiline VL650) manufactured by METTLER TOLEDO.
The test subjects calculate various skin indicators before and after the use of the pharmaceutical composition, as in example 2.
The test results are shown in the following table.
TABLE 2 statistical Table of facial skin effects of subjects
| Group of | Before treatment | After treatment |
| Facial water content | 43.50±4.22 | 68.55±8.24 |
| Water loss through epidermis (%) | 13.60±6.50 | 18.85±3.13 |
| Skin oil | 32.50±4.50 | 17.80±3.40 |
| Index of skin friction | 420.34±79.50 | 320.81±50.96 |
| Skin elasticity parameter | 0.51±0.13 | 0.76±0.19 |
| Wrinkle (mm)2) | 54.60±8.89 | 34.40±6.12 |
As shown in Table 2, the traditional Chinese medicine composition provided by the invention can achieve very remarkable effects of keeping skin moisture and elasticity and reducing wrinkle area within 4 weeks after being tried by a large number of patients, and has lasting effect, no side effect and high user evaluation.
Example 3 ameliorating effect of the Chinese medicinal composition of the present application on menstrual disorder
60 subjects with menstrual disorders were enrolled in a cooperative medical clinic (cooperative clinic requires unfair names):
and (3) inclusion standard: (1) women aged 35-50 years; (2) irregular menstruation including dysmenorrhea, irregular menstrual cycle, excessive or deficient menstruation and other problems (3) absence of severe systemic diseases and non-allergic constitution; (4) can be performed strictly according to the requirements of the research scheme and signed with an informed consent.
Exclusion criteria: (1) sensitive constitution or history of Chinese medicinal allergy; (2) pregnant or lactating women; (3) the hormone medicine and the immunosuppressant are used in the last month, and the tested part takes part in other clinical testers at the present or last three months.
Rejection standard: serious adverse reactions occurred during the experiment and the study protocol was not followed.
The improvement effect of the traditional Chinese medicine composition on the menstrual disorder is researched by adopting a self-front-back control mode. The intervention mode is that the traditional Chinese medicine composition is taken once a day, 50ml of the traditional Chinese medicine composition is taken after supper every time, the observation treatment course is 4 weeks, and menstrual period symptoms, menstrual blood volume, color and menstrual period are observed. Efficacy was assessed, with the following criteria: the effect is shown: the clinical symptoms of the patient disappear after treatment, the menstrual regularity, the menstrual period time and the blood volume and color are normal after treatment; the method has the following advantages: the clinical symptoms are improved after treatment, and the blood volume, the color and the menstrual period time are improved; and (4) invalidation: the traditional Chinese medicine does not meet the above standard, the menstruation does not return to the normal rule, and the total effective rate is significant efficiency plus effective rate.
The test results are shown in the following table.
TABLE 3 statistical table of treatment effect of irregular menstruation
| Total number of people | Show effect | Is effective | Invalidation |
| 60 | 20 | 36 | 4 |
As shown in Table 3, a large number of patients try out the traditional Chinese medicine composition provided by the invention, the effect of remarkably improving irregular menstruation can be achieved within 4 weeks, the total effective rate can reach about 93% after 4 weeks, and the curative effect is remarkable.
In summary, the traditional Chinese medicine composition realizes effective regulation and nourishing of qi and blood of women with safe (whole food ingredients), simple formula and convenient use mode, and has the effect of practically improving skin conditions, menstrual disorder and other related problems. Is suitable for long-term administration as medicine, health product or even common food.
Claims (10)
1. A traditional Chinese medicine composition for regulating and nourishing female qi and blood is characterized in that raw materials comprise Chinese yam, gordon euryale seed, fried coix seed, white hyacinth bean, red bean, lotus seed, rhizoma polygonati, longan, black date and wolfberry fruit.
2. The traditional Chinese medicine composition according to claim 1, wherein the raw materials comprise, by weight, 20-50 parts of Chinese yam, 20-40 parts of gordon euryale seed, 20-40 parts of fried coix seed, 20-40 parts of white hyacinth bean, 20-40 parts of rice bean, 30-60 parts of lotus seed pulp, 10-30 parts of rhizoma polygonati, 10-30 parts of longan, 20-50 parts of black date and 20-40 parts of wolfberry fruit.
3. The traditional Chinese medicine composition according to claim 2, wherein the raw materials comprise 30 parts by weight of Chinese yam, 30 parts by weight of gordon euryale seed, 30 parts by weight of fried coix seed, 30 parts by weight of white hyacinth bean, 30 parts by weight of red bean, 50 parts by weight of lotus seed pulp, 20 parts by weight of rhizoma polygonati, 20 parts by weight of longan, 30 parts by weight of black date and 30 parts by weight of wolfberry fruit.
4. The traditional Chinese medicine composition according to claim 3, characterized in that the raw materials comprise 30 parts by weight of Chinese yam, 30 parts by weight of gordon euryale seed, 30 parts by weight of fried coix seed, 30 parts by weight of white hyacinth bean, 30 parts by weight of rice bean, 50 parts by weight of lotus seed pulp, 20 parts by weight of rhizoma polygonati, 20 parts by weight of longan, 30 parts by weight of black date, 30 parts by weight of medlar, 1500 parts by weight of white spirit and 40 parts by weight.
5. The Chinese medicinal composition according to claim 4, wherein the Chinese liquor is a 26-degree alcohol Chinese liquor.
6. A method for preparing a Chinese medicinal composition according to any one of claims 1 to 5, which comprises soaking Chinese yam, gordon euryale seed, parched pearl barley, white hyacinth bean, red bean, lotus seed, polygonatum rhizome, longan, black date and wolfberry fruit in Chinese liquor, followed by adding crystal sugar.
7. The method of claim 6, comprising the steps of:
(1) weighing required medicines, cleaning and then drying;
(2) pulverizing the dried Chinese medicinal materials to 70-100 mesh;
(3) putting the pulverized Chinese medicinal materials into gauze bag to make medicated bag;
(4) immersing the medicine bag obtained in the step (3) into white spirit;
(5) taking out the medicated bag, adding crystal sugar into Chinese liquor, and slightly stirring to melt the crystal sugar.
8. The preparation method according to claim 7, wherein the pouch is immersed in the white spirit for 12 to 120 hours in the step (4).
9. The use of the Chinese medicinal composition according to any one of claims 1 to 5 for regulating and nourishing qi and blood of women.
10. Use according to claim 9, wherein regulating qi and blood in women comprises improving facial skin conditions and/or regulating menstrual disorders.
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