CN108578603A - Chinese medicine compound prescription and its application of type knee osteoarthritis are lost based on " few main bone of sun " theoretical treatment kidney deficiency marrow - Google Patents
Chinese medicine compound prescription and its application of type knee osteoarthritis are lost based on " few main bone of sun " theoretical treatment kidney deficiency marrow Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
The invention discloses the Chinese medicine compound prescriptions that type knee osteoarthritis is lost based on " few main bone of sun " theoretical treatment kidney deficiency marrow, and by weight, the Chinese medicine compound prescription includes：15~20 parts of stir-baked RADIX BUPLEURI with vinegar, 10~12 parts of stir-baked RADIX PAEONIAE ALBA, 10~12 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China, 5~10 parts of radix cyathulae, 5~10 parts of stir-baked CORTEX EUCOMMIAE with salt solution, fries 10~12 parts of coix seed, 10~12 parts of PORIA ALBA, 5~10 parts of costus root, 5~10 parts of Rhizoma Chuanxiong, 10~12 parts of honey-fried licorice root at 10~12 parts of stir-baked RADIX SCUTELLARIAE.The Chinese medicine compound prescription that treatment kidney deficiency marrow of the present invention loses type knee osteoarthritis is in the case where " few main bone of sun " is theoretical, it then follows the principles of formulating prescriptions of Chinese medicine " monarch ", each drug component synergistic effect have effects that harmonizing Sharyang, the regulation of qi and blood, swelling and pain relieving；The Chinese Herbs are notable, have no toxic side effect, is easy to use, is cheap.
Description
Technical field
The invention belongs to technical field of traditional Chinese pharmacology, it is related to a kind of using Chinese herbal medicine as the Chinese medicine compound prescription of raw material, is specially based on
" few main bone of sun " theoretical treatment kidney deficiency marrow loses Chinese medicine compound prescription and its application of type knee osteoarthritis.
Background technology
Knee osteoarthritis is a kind of degeneration bone and joint diseases, is the arthropathy that the elderly is common, multiple, typical pathologic
It is formed characterized by articular cartilage damage, Subchondral bone sclerosis and spur.According to statistics, it is closed with bone in the people in China about 3%
Section is scorching, and knee osteoarthritis accounts for most of ratio, and the long-term disability rate of 50 years old or more Human Osteoarthritis is only second to angiocarpy
Disease ranks second.With the continuous acceleration of China human mortality aging, the harmfulness of knee osteoarthritis is also gradually increased.At present
Western medical treatment is broadly divided into knee replacements and expectant treatment, and operative treatment is secondary to overhaul there are high cost, pain are larger
The problems such as, and also there are many stomach and intestine with oral non-steroid anti-inflammatory drug and the injection of hyaluronic acid knee for the expectant treatment of representative
The drawbacks of road adverse reaction and easily accompanying infection.Compared to the limitation of western medical treatment, Chinese medicine knee osteoarthritis history
It is long, it is experienced, there are the inherent advantages such as significant in efficacy, safety is good.Knee osteoarthritis belongs to Chinese medicine " heumatism " scope, existing
With caused by liver and kidney deficiency in mostly thinking the heumatism interpretation of the cause, onset and process of an illness nothing more than for doctor, disorder of qi and blood is this, and with chill is wet etc., the resistance of exopathogens numbness is outside
Mark, but often only theoretical for guidance with " Shen controls bone " is tonified the liver and kidney, the prescribed treatments such as wind expelling stagnation removing, is lacked to the disease
Whole understanding.
Knee osteoarthritis (heumatism) is divided into kidney deficiency marrow and loses type, deficiency of yang cold-condensing type and type of stagnation of blood stasis by traditional Chinese medicine, because of its trouble
Person is mostly the elderly, therefore clinical to lose type especially with kidney deficiency marrow the most common.Nanjing University of Traditional Chinese Medicine professor Ma Yong is as Shi school traumatology
5th generation inheritance people is an apprentice of national orthopedics and traumatology of Chinese medicine famous expert Shi Qi professors, and by clinical practice for many years, experience is demonstrate,proved in Shi Laolin
On the basis of, by the way that " few main bone of sun " compares with " Shen controls bone " theory, discovery is distinguished only with " Shen controls bone " theory controls presence
Limitation, novelty propose from " expenditure " angle start with treatment kidney deficiency marrow lose type knee osteoarthritis.Type is lost in treatment kidney deficiency marrow
When knee osteoarthritis, kidney tonifying drug is not only used merely, should more be started with from the angle of " expenditure ", and then its interpretation of the cause, onset and process of an illness is summarized as
" dysfunction of SHAO YANG, qi and blood muscles and bones, which is lost, supports ", and it is the big method for the treatment of to have founded with harmonizing Sharyang, the regulation of qi and blood, swelling and pain relieving
Few sun knee numbness side, can obtain good effect in clinical application.
Invention content
The technical issues of solution：In order to overcome the deficiencies of existing technologies, solve merely to tonify the liver and kidney, wind expelling stagnation removing etc.
Side's treatment is existing insufficient, and acquisition is a kind of to have harmonizing Sharyang, the regulation of qi and blood, swelling and pain relieving and other effects, and makees without pair safely
Chinese medicine composition, the present invention provides the Chinese medicines that type knee osteoarthritis is lost based on " few main bone of sun " theoretical treatment kidney deficiency marrow
Compound and its application.
Technical solution：The Chinese medicine compound prescription that type knee osteoarthritis is lost based on " few main bone of sun " theoretical treatment kidney deficiency marrow, by weight
Part meter is measured, the Chinese medicine compound prescription includes：15~20 parts of stir-baked RADIX BUPLEURI with vinegar, 10~12 parts of stir-baked RADIX SCUTELLARIAE, 10~12 parts of stir-baked RADIX PAEONIAE ALBA, RADIX CODONOPSIS PILOSULAE from Shanxi of China 10
~12 parts, 5~10 parts of radix cyathulae, 5~10 parts of stir-baked CORTEX EUCOMMIAE with salt solution, fry 10~12 parts of coix seed, 10~12 parts of PORIA ALBA, costus root 5~
10 parts, 5~10 parts of Rhizoma Chuanxiong, 10~12 parts of honey-fried licorice root.
Preferably, the stir-baked RADIX BUPLEURI with vinegar, stir-baked RADIX SCUTELLARIAE are monarch drug in a prescription；Stir-baked RADIX PAEONIAE ALBA, RADIX CODONOPSIS PILOSULAE from Shanxi of China, radix cyathulae, stir-baked CORTEX EUCOMMIAE with salt solution are ministerial drug；Fry the heart of a lotus seed
The seed of jog's tears, PORIA ALBA, costus root, Rhizoma Chuanxiong, honey-fried licorice root are adjuvant.
Preferably, the dosage form of the Chinese medicine compound prescription is decoction, granule or capsule.
Application of any description above Chinese medicine compound prescription in preparing treatment kidney deficiency marrow and losing type knee osteoarthritis drug.
The Chinese medicine compound prescription of the present invention that type knee osteoarthritis is lost based on " few main bone of sun " theoretical treatment kidney deficiency marrow, it is each
The drug action mechanism of component is as follows：
Radix bupleuri, pharmacological property is bitter, it is pungent, be slightly cold, Return liver, gallbladder channel.Inducing diaphoresis is brought down a fever, and soothing liver-qi stagnation rises and lifts yang-energy.It is sent out for diseases caused by external factors
Heat, fevers and chills alternate, malaria, liver-depressed hypochondrium pain mammary swelling, headache and dizziness, irregular menstruation, under the rectal prolapse of collapse from qi deficiency, the prolapse of uterus, stomach
It hangs down.(《Dictionary of medicinal plant》The Shanghai science tech publishing house second edition page 2572 is write by Nanjing University of Traditional Chinese Medicine).
Radix scutellariae, pharmacological property hardship, cold, return lung, the heart, liver, courage, large intestine channel.Clearing heat-fire, eliminating dampness removing toxic substances, hemostasis, tocolysis.For
Cough with lung heat, high fever apoplexy coma due to blocking of the respiratory system shies epilepsy, irascibility headache, red eye, swell pain, jaundice with damp-heat pathogen, rush down dysentery, heat gonorrhea, hematemesis, uterine bleeding, tire heat is not
Peace, carbuncle swells furunculosis.(《Dictionary of medicinal plant》The Shanghai science tech publishing house second edition page 2808 is write by Nanjing University of Traditional Chinese Medicine).
Radix Paeoniae Alba, pharmacological property is bitter, acid, is slightly cold, Return liver, the spleen channel.Strengthening the spleen and tonifying the lung, nourishing generate fluid.For weakness of the spleen and the stomach, deficiency of food is just
Half congealed, limbs fatigue, the deficiency syndrome of the lung is breathed with cough, shortness of breath and spontaneous perspiration, all cards of qi-blood deficiency.(《Dictionary of medicinal plant》Nanjing University of Traditional Chinese Medicine writes
Extra large science tech publishing house's second edition page 706).
Radix Codonopsis, pharmacological property is sweet, flat, return lung, the spleen channel.Smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, the side of body
Bitterly, abdominal pain, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.(《Dictionary of medicinal plant》Nanjing University of Traditional Chinese Medicine writes
The Shanghai science tech publishing house second edition page 2579).
The root of bidentate achyranthes, pharmacological property is bitter, sour, flat, returns liver and kidney channel.Filling liver kidney, strengthening the bones and muscles, invigorate blood circulation, downlink of igniting, inducing diuresis for treating strangurtia.
For soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhoea, postpartum abdominal pain due to blood stasis, abdominal mass, placenta retension, heat gonorrhea, blood strangury, bruise
Damage, Carbuncle swells dislikes sore, abscess of throat.(《Dictionary of medicinal plant》Shanghai science tech publishing house second is write by Nanjing University of Traditional Chinese Medicine
Version page 570).
Cortex Eucommiae, pharmacological property is sweet, micro-pungent, temperature, returns liver and kidney channel.Filling liver kidney, strengthening the bones and muscles, tocolysis.For soreness and weakness of waist and knees, impotence, urine
Frequently, dribbling urination, arthralgia pain due to rheumatism, fetal irritability, habitual abortion.(《Dictionary of medicinal plant》Shanghai is write by Nanjing University of Traditional Chinese Medicine
Science tech publishing house's second edition page 1514).
Coix seed, pharmacological property is sweet, it is light, be slightly cold, returns spleen, stomach, lung channel.Dampness removing invigorating the spleen, relaxing muscles and tendons eliminating impediment, clearing away heat and eliminating pus.For water
It is swollen, tinea pedis, dribbling urination, damp-warm diseases, diarrhea, under, arthralgia pain due to rheumatism, muscle arteries and veins contraction, lung carbuncle, acute appendicitis, flat wart.(《Chinese medicine is big
Dictionary》The Shanghai science tech publishing house second edition page 3725 is write by Nanjing University of Traditional Chinese Medicine).
Poria cocos, pharmacological property is sweet, light, flat, the thoughts of returning home, spleen, lung, kidney channel.Clearing damp and promoting diuresis, strengthening the spleen and stomach, antitoxic heart-soothing and sedative.For urine
It is unfavorable, oedema turgor, phlegm and retained fluid cough is inverse, vomiting, spleen eating less, diarrhea, palpitation and restlessness, insomnia forgetfulness, gonorrhoea of passing out semen.(《Chinese medicine is big
Dictionary》The Shanghai science tech publishing house second edition page 2154 is write by Nanjing University of Traditional Chinese Medicine).
Root of Aucklandia lappa Decne, pharmacological property acrid, bitter, warm, returns spleen, stomach, liver, lung channel.Promoting qi circulation and relieving pain is led in tune stagnant.For fullness in chest and hypochondrium, gastral cavity abdomen
Distending pain, vomiting and diarrhea, weight after dysentery.(《Dictionary of medicinal plant》Shanghai science tech publishing house second is write by Nanjing University of Traditional Chinese Medicine
Version page 480).
Rhizoma Chuanxiong, pharmacological property is pungent, warm, Return liver, courage, pericardium channel.Promoting blood circulation, promote breath and open depression, wind-expelling pain-stopping.Not for menstruation
It adjusts, closed dysmenorrhea, postpartum stasis of blood, abdominal mass lump, pain in chest and hypochondrium, dizziness of having a headache, wind-cold-dampness arthralgia, traumatic injury, ulcer sore
Ulcer.(《Dictionary of medicinal plant》The Shanghai science tech publishing house second edition page 292 is write by Nanjing University of Traditional Chinese Medicine).
Radix Glycyrrhizae, sweet, flat, returns spleen, stomach, the heart, lung channel.With middle emergency, moistening lung is understood, coordinating the drug actions of a prescription.Toast is empty with taste are controlled
It is weak, burnout deficiency of food, abdominal pain loose stool, four limbs contraction, palpitaition, hysteria, consumptive lung disease cough.(《Dictionary of medicinal plant》Nanjing traditional Chinese medicine
The Shanghai science tech publishing house second edition page 792 is write by university).
Advantageous effect：(1) Chinese medicine compound prescription that treatment kidney deficiency marrow of the present invention loses type knee osteoarthritis is in " few sun master
Under bone " is theoretical, it then follows the principles of formulating prescriptions of Chinese medicine " monarch ", each drug component synergistic effect have harmonizing Sharyang, reconciliation gas
The effect of blood, swelling and pain relieving；(2) Chinese medicine includes saponin(e, protein, glucose, volatile oil, fructose, organic acid, lecithin
Fat, vitamin, amino acid, phytosterol and various trace elements are conducive to absorption of human body, improve constitution；(3) the middle medication
Effect is notable, has no toxic side effect, is easy to use, is cheap.
Specific implementation mode
The content that following embodiment further illustrates the present invention, but should not be construed as limiting the invention.Without departing substantially from
In the case of spirit of that invention and essence, to changing and replacing made by the method for the present invention, step or condition, the present invention is belonged to
Range.Unless otherwise specified, the conventional means that technological means used in embodiment is well known to those skilled in the art.
Embodiment 1
The Chinese medicine compound prescription of type knee osteoarthritis, by weight, institute are lost based on " few main bone of sun " theoretical treatment kidney deficiency marrow
Stating Chinese medicine compound prescription includes：20 parts of stir-baked RADIX BUPLEURI with vinegar, 12 parts of stir-baked RADIX SCUTELLARIAE, 12 parts of stir-baked RADIX PAEONIAE ALBA, 10 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China, 9 parts of radix cyathulae, stir-baked CORTEX EUCOMMIAE with salt solution 9
Part fries 10 parts of coix seed, 12 parts of PORIA ALBA, 10 parts of costus root, 10 parts of Rhizoma Chuanxiong, 10 parts of honey-fried licorice root.
The radix bupleuri, radix scutellariae are monarch drug in a prescription；Radix Paeoniae Alba, Radix Codonopsis, the root of bidentate achyranthes, Cortex Eucommiae are ministerial drug；Coix seed, Poria cocos, root of Aucklandia lappa Decne, Rhizoma Chuanxiong and
Honey-fried licorice root is adjuvant.
The dosage form of the Chinese medicine compound prescription is decoction.
The decoction is made by following methods：Raw material is cleaned into impurity elimination, dries, be ground into particle, is soaked, big fire is boiled
After boiling, slow boiling is simmered 40 minutes, and every dose decocts 2 times to obtain the final product.
Embodiment 2
The Chinese medicine compound prescription of type knee osteoarthritis, by weight, institute are lost based on " few main bone of sun " theoretical treatment kidney deficiency marrow
Stating Chinese medicine compound prescription includes：15 parts of stir-baked RADIX BUPLEURI with vinegar, 12 parts of stir-baked RADIX SCUTELLARIAE, 12 parts of stir-baked RADIX PAEONIAE ALBA, 10 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China, 9 parts of radix cyathulae, stir-baked CORTEX EUCOMMIAE with salt solution 9
Part fries 10 parts of coix seed, 12 parts of PORIA ALBA, 10 parts of costus root, 10 parts of Rhizoma Chuanxiong, 10 parts of honey-fried licorice root.
The stir-baked RADIX BUPLEURI with vinegar, stir-baked RADIX SCUTELLARIAE are monarch drug in a prescription；Stir-baked RADIX PAEONIAE ALBA, RADIX CODONOPSIS PILOSULAE from Shanxi of China, radix cyathulae, stir-baked CORTEX EUCOMMIAE with salt solution are ministerial drug；Fry coix seed, white
Poria cocos, costus root, Rhizoma Chuanxiong, honey-fried licorice root are adjuvant.
The dosage form of the Chinese medicine compound prescription is granule.
The granule is made by following methods：It is decocted 2 times with the clear water of 6 times of amounts of crude drug, 40 minutes every time, merges water
Extract, and it is concentrated to give extract after being depressurized at 60 DEG C, appropriate Icing Sugar and stabilizer is added, crosses 40 mesh sieve, obtains granule, dispense
Afterwards.
Embodiment 3
The Chinese medicine compound prescription of type knee osteoarthritis, by weight, institute are lost based on " few main bone of sun " theoretical treatment kidney deficiency marrow
Stating Chinese medicine compound prescription includes：20 parts of stir-baked RADIX BUPLEURI with vinegar, 12 parts of stir-baked RADIX SCUTELLARIAE, 12 parts of stir-baked RADIX PAEONIAE ALBA, 10 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China, 9 parts of radix cyathulae, stir-baked CORTEX EUCOMMIAE with salt solution 9
Part fries 10 parts of coix seed, 12 parts of PORIA ALBA, 10 parts of costus root, 10 parts of Rhizoma Chuanxiong, 10 parts of honey-fried licorice root.
The stir-baked RADIX BUPLEURI with vinegar, stir-baked RADIX SCUTELLARIAE are monarch drug in a prescription；Stir-baked RADIX PAEONIAE ALBA, RADIX CODONOPSIS PILOSULAE from Shanxi of China, radix cyathulae, stir-baked CORTEX EUCOMMIAE with salt solution are ministerial drug；Fry coix seed, white
Poria cocos, costus root, Rhizoma Chuanxiong, honey-fried licorice root are adjuvant.
The dosage form of the Chinese medicine compound prescription is capsule.
The capsule is made by following methods：Crude drug is put into the clear water of 8 times of crude drug amount and decocts 2 times, every time
30 minutes, merge Aqueous extracts, Chinese medicinal compound extract is concentrated under reduced pressure to give in 60 DEG C of Aqueous extracts, crush, crosses 60 mesh sieve, be packed into
The capsule got ready to obtain the final product.
Embodiment 4 treats kidney deficiency marrow and loses type knee osteoarthritis clinical observation research
1 case selection
1.1 case sources
In May, 2017 is in December, 2017 in the kneecap joint of Nanjing Traditional Chinese Medicine Univ. affiliated hospital orthopedics and traumatology outpatient clinic
Scorching patient.
1.2 tcm diagnosis standard
With reference to People's Republic of China's traditional Chinese medicine industry standard ---《Chinese medical disease Standardization of diagnosis and curative effect (1994 editions)》System
Determine kidney deficiency marrow and loses type knee osteoarthritis (heumatism) diagnostic criteria, it is as follows：
(1) from the beginning of when common knee joint have a dull ache, joint stuffiness, light activity is slightly alleviated, and climate change aggravates, repeatedly
It is touching not to be cured, soreness and weakness of waist and knees.With dizziness, tinnitus is deaf, dizzy.Pink tongue, tongue are thin white, and arteries and veins is thin.
(2) insidious onset, morbidity is slow, is more common in person in middle and old age.
(3) knee joint can mild swelling, often there are noise made in coughing or vomiting thorn sound or grating in joint when movable.The visible muscular atrophy of severe patient,
Joint deformity.
(4) x-ray inspection：Show osteoporosis, articular surface is irregular, and joint space is narrow, subchondral bony sclerosis, Yi Jibian
Edge lip sample changes, and spur is formed.
1.3 Western medicine diagnostic criteria
Western medicine diagnostic criteria is formulated with reference to osteology branch of Chinese Medical Association《Osteoarthritis diagnosis and treatment guide (2007
Version)》.1. gonalgia repeatedly in nearly 1 month；2. X-ray piece shows that joint space narrows, Subchondral bone sclerosis and (or) capsule
Become, joint margins spur is formed；3. joint fluid is transparent, stickiness, 2000/mL of leukocyte count ＜ are shown in inspection；4. age >=40 year old；⑤
The morning stiffness time≤30min；6. feeling there is bony crepitus when activity.1. 2. or 1. 3. 5. 6. or 1. 4. 5. 6. having above-mentioned can examine
It is disconnected.
1.4 x-ray grade scales
With reference to《Chinese medical disease Standardization of diagnosis and curative effect》Middle osteoarthritis Kellgren-Lawrance grade scales, 0 grade：Just
Often；I grade：Slight spur；II grade：Apparent spur, joint space is suspicious to narrow；III grade：Joint space moderate narrows, under cartilage
Osteosclerosis；IV grade：A large amount of spurs, joint space obviously narrow, osteosclerosis and apparent deformity under severe cartilage.
1.5 inclusion criteria
(1) meet knee osteoarthritis tcm diagnosis standard；
(2) meet knee osteoarthritis Western medicine diagnostic criteria；
(3) male or female, the age is between 40~80 years old；
(4) if patient has received other operative treatments, 7 days elution phases need to be passed through；
(5) fully know testing program and sign informed consent form.
Above five do not meet person and can just be included in.
1.6 exclusion criteria
(1) there are the persons such as acute synovitis, infection, tuberculosis, rheumatic arthritis, rheumatoid arthritis for knee joint；
(2) there is digestive tract ulcer medical history, the person that once received operation on digestive tract；
(3) merge the internal medicine underlying diseases such as the serious heart, brain, liver, kidney and respiratory system, phrenoblabia, genetic disease
The whole bodies major disease person such as person, tumour；
(4) antalgesics such as non-steroid anti-inflammatory drug, opiates were taken orally within nearly 1 month, received in whole body or articular cavity
Hormone therapy, intracavitary administration or arthroscopy person were carried out to knee joint in 3 months；
(5) allergic constitution person；
(6) patient of other drugs clinical test is being participated in；
(7) compliance is poor, it is difficult to which go to a doctor follow-up person on time；
(8) lactation, gestation or the women for preparing gestation.
There is the person of meeting to need to exclude above.
1.7 fall off standard
1. subject's compliance is poor, curer cannot be participated according to quantity on time.
2. serious adverse reaction, complication occurs, it should not examination person again.
3. due to other a variety of causes person lost to follow-up.
Subject meets any of the above one, for the case that falls off.
1.8 reject standard
1. meeting inclusion criteria, but the subject being randomly assigned is not carried out in accordance with regulations for some reason by researcher.
2. repeating enrolled subject.
3. subject because a variety of causes is unwilling to continue clinical test, fails to complete treatment course, active bolter.
4. subject is voluntarily using the Chinese and western drugs or therapy in non-research prescribed limit in treatment course.
5. can not judged that curative effect or data be not congruent by regulation medication and be affected the treatment and safety judgement person.
Subject meets any of the above one, eliminates this research.
1.9 cases exit the program
1. researcher makes a report on case and exits table, including patient number, name, the age, group, exits reason etc..
2. determining that case exits reason and avoiding measures, and makes a report on and exit table in case.
Subject meets any of the above one, can exit this research.
2 random groupings and shielding
28 subjects of this project come from Nanjing Traditional Chinese Medicine Univ. affiliated hospital orthopedics and traumatology out-patient, in subject's base
After this data collection finishes and signs informed consent form, researcher is numbered each patient using number software, uses
Table of random number is assigned to according to subject number in observation group and control group, and by grouping information to encrypt Microsoft Excel shape
Formula is stored in laptop, which finishes grouping information from preservation and complete not to be then turned on to experiment, before opening password
Half part is arranged by project third responsible person, and latter half is arranged by the 6th responsible person, and after the test, two responsible persons will be close
Code, which merges, opens EXCEL, and random grouping and the work of shielding grouping information are completed jointly by two researchers, and this two are ground
The collection and the data analysis after the completion of experiment that the person of studying carefully does not participate in patient information.Due to the native form of the intervening measure of this experiment
Difference, we can not accomplish the double blind of clinician and patient, therefore selected single blind, i.e., all responsible data statistics and commented
The researcher estimated is not involved in and ignorant patient being included in and is grouped.
3 therapies
Control group：Give meloxicam tablet (macro strong) (Yangzijiang Pharmaceutical Group Co., Ltd, Chinese medicines quasi-word H20010207
Number), specification 7.5mg × 10 piece/box.Usage：It is oral, one at a time, one time a day, one after each meal.4 weeks as a treatment course, continuously
It takes 2 course for the treatment of.This product main component is Meloxicam, is suitable for the symptom treatment of rheumatoid arthritis, and painful bone closes
The symptom treatment of section scorching (arthropathy, degenerative osteoarthropathy).
Treatment group：Give few positive knee numbness side, drug composition：Stir-baked RADIX BUPLEURI with vinegar 15g, stir-baked RADIX SCUTELLARIAE 12g, stir-baked RADIX PAEONIAE ALBA 10g, RADIX CODONOPSIS PILOSULAE from Shanxi of China 10g,
Radix cyathulae 9g, stir-baked CORTEX EUCOMMIAE with salt solution 9g, coix seed 10g, PORIA ALBA 10g, costus root 6g, Rhizoma Chuanxiong 9g, honey-fried licorice root 10g are fried, can be added and subtracted with disease.
Chinese medicine is produced by Nanjing Traditional Chinese Medicine Univ. affiliated hospital Chinese medicine preparation section according to pharmaceutical preparation normal process.Top adds water 500ml
It decocts twice, takes juice 300ml, daily 1 dose, morning and evening sub-service, continuous use 8 weeks.
4 observation indexs
(1) general data
Including name, gender, age, height, weight, medical history etc..
(2) validity observation index
(the The Western Ontario and McMaster 1. western lake generally and Cecil McMaster Osteoarthritis score
Universities Osteoarthritis Index,WOMAC)
This marking scales assesses kneed structure and function from pain, stiff and three broad aspect of function of joint, in total
There are 24 projects, contains cardinal symptom and the sign of entire osteoarthritis.There are 5 projects, stiff in the part of wherein pain
There are 2 projects in part, there are 17 projects in the part of function of joint.Score can use VAS (visual analog when noting down
Scale) scale.Symptom and sign quantization assessment standard in specific for details, see the appendix case observation table.
2. health survey abridged table (the MOS item short from health survey, SF-36)
8 aspects of the Scale assessment Progress of Health-related Quality of Life, belong to two major class of physiological health and mental health
In, i.e. physiological function (Physical Function), physiological function (Role Physical), body pain (Bodily
Pain), general health (General Health), vigor (Vitality), social function (Social Function), emotion
Functional (Role Emotional), mental health (Mental Health).One by one assessment patient each option score,
Finally carry out score record.
(3) safety observations
Monitor the indexs such as patient's blood, urine, stool routine, hepatic and renal function.Record faithfully any adverse reaction occurred after medication
And adverse events, including the time of the appearance such as general reaction and digestive tract reaction and degree, if drug withdrawal and treatment measures.
(4) observation time point
These parameters are observed and recorded before treatment, after treatment within 8 weeks.
5 statistical methods
Using SPSS 19.0 statistical softwares typings and analysis data, the missing data of curative effect relevant portion uses before most
The method that once observation data are carried down afterwards is supplemented.Measurement data use ± s indicates, meets normal distribution and the neat meter of variance
Amount data is examined using t, and heterogeneity of variance is examined using t ', and do not meet normal distribution uses non-parametric test.Enumeration data
Using χ2It examines, ranked data are analyzed using Ridit or rank sum test.Test stone α=0.05.
6 treatment results
6.1 WOMAC score
Comparison among groups：Treat the not statistically significant (P of preceding two groups of WOMAC diversity of values>0.05), the stiff for the treatment of group is commented
Divide, function of joint scoring and total score are substantially less than control group (P<0.05), and two groups of pain scores compare no significant difference (P
＞ 0.05)；In group relatively：8 weeks two groups of each item ratings of WOMAC are obviously higher than (the P that scores before respective treatment after treatment<0.05).
It is shown in Table 1.
6.2 SF-36 score
Comparison among groups：Treat the not statistically significant (P of preceding two groups of SF-36 diversity of values>0.05).8 weeks treatment groups after treatment
Physiological function (P=0.046), body pain (P=0.036) and general health (P=0.020) scoring be all remarkably higher than pair
According to group；Emotion function group difference is close to statistical significance (P=0.052)；Physiological function, vigor, social function and essence
Refreshing health no difference of science of statistics (P>0.05)；In group relatively：Before each item ratings of SF-36 are above treatment after two groups of treatments, difference
With statistical significance (P<0.05).It is shown in Table 1
1 treatment group of table (n=13) is before control group (n=12) treatment after treatment compared with 8 weeks
Clinical observation result shows losing type to kidney deficiency marrow with " few main bone of sun " theoretical Chinese medicine compound prescription of the present invention for guidance
The symptom of Patients with Knee Osteoarthritis, sign tool improve significantly, and clinical efficacy is definite, prompts Chinese medicine compound prescription pair of the present invention
Alleviate and improve kidney deficiency marrow and lose type knee osteoarthritis with benign adjustment effect, and takes without any adverse reactions, value for a long time
It must be further developed as the drug that a new generation's treatment kidney deficiency marrow loses type knee osteoarthritis.
Claims (4)
1. losing the Chinese medicine compound prescription of type knee osteoarthritis based on " few main bone of sun " theoretical treatment kidney deficiency marrow, which is characterized in that by weight
Part meter is measured, the Chinese medicine compound prescription includes：15~20 parts of stir-baked RADIX BUPLEURI with vinegar, 10~12 parts of stir-baked RADIX SCUTELLARIAE, 10~12 parts of stir-baked RADIX PAEONIAE ALBA, RADIX CODONOPSIS PILOSULAE from Shanxi of China 10
~12 parts, 5~10 parts of radix cyathulae, 5~10 parts of stir-baked CORTEX EUCOMMIAE with salt solution, fry 10~12 parts of coix seed, 10~12 parts of PORIA ALBA, costus root 5~
10 parts, 5~10 parts of Rhizoma Chuanxiong, 10~12 parts of honey-fried licorice root.
2. the Chinese medicine according to claim 1 for losing type knee osteoarthritis based on " few main bone of sun " theoretical treatment kidney deficiency marrow is multiple
Side, which is characterized in that the stir-baked RADIX BUPLEURI with vinegar, stir-baked RADIX SCUTELLARIAE are monarch drug in a prescription；Stir-baked RADIX PAEONIAE ALBA, RADIX CODONOPSIS PILOSULAE from Shanxi of China, radix cyathulae, stir-baked CORTEX EUCOMMIAE with salt solution are ministerial drug；Fry the heart of a lotus seed
The seed of jog's tears, PORIA ALBA, costus root, Rhizoma Chuanxiong, honey-fried licorice root are adjuvant.
3. the Chinese medicine according to claim 1 for losing type knee osteoarthritis based on " few main bone of sun " theoretical treatment kidney deficiency marrow is multiple
Side, which is characterized in that the dosage form of the Chinese medicine compound prescription is decoction, granule or capsule.
4. application of any Chinese medicine compound prescription of claims 1 to 3 in preparing treatment kidney deficiency marrow and losing type knee osteoarthritis drug.
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