CN112915175A - Anti-fatigue traditional Chinese medicine composition tablet and preparation method thereof - Google Patents
Anti-fatigue traditional Chinese medicine composition tablet and preparation method thereof Download PDFInfo
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- CN112915175A CN112915175A CN202011605467.0A CN202011605467A CN112915175A CN 112915175 A CN112915175 A CN 112915175A CN 202011605467 A CN202011605467 A CN 202011605467A CN 112915175 A CN112915175 A CN 112915175A
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Abstract
The invention relates to an antifatigue Chinese medicinal composition tablet and its preparation method, Chinese medicinal composition tablet raw materials component regards mutton, semen Cuscutae, herba Epimedii, rhizoma Curculiginis, herba cistanches, fructus Ligustri Lucidi, fructus Schisandrae chinensis, fructus Alpinae Oxyphyllae, fructus Rubi, rhizoma Drynariae, herba Taxilli, radix rehmanniae Preparata, rhizoma Polygonati, herba Dendrobii, ginseng, cornu Cervi Pantotrichum, radix astragali, radix Codonopsis Pilosulae, cortex Phellodendri, fructus Lycii, etc. as principal drug, regard radix Puerariae, Poria, fructus Jujubae, orange rind, fructus Amomi, rhizoma Atractylodis Macrocephalae, fructus Tritici Levis, arillus longan, rhizoma Zingiberis, etc. as the subsidiary drug, pharmacological interaction among each principal drug, it has effects of invigorating kidney, replenishing vital essence, nourishing liver, improving eyesight, invigorating spleen, benefiting; the preparation method of the traditional Chinese medicine composition tablet prepares the traditional Chinese medicine composition tablet by crushing, extracting, concentrating, granulating, tabletting and other modes, is easy to be absorbed by human body, gives full play to the good drug effect among main drugs, and further accelerates to achieve the aim of relieving fatigue symptoms.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine tablets, in particular to an anti-fatigue traditional Chinese medicine composition tablet and a preparation method thereof.
Background
Modern people live fast, because of heavy working pressure, sleep time is less and less, and sub-health becomes one of the considerable problems of modern people. In long-term work at desk, staff have symptoms of consumptive disease, lassitude and the like, and are easy to cause immunity reduction and diseases for a long time. The traditional Chinese medicine holds that the kidney is the congenital foundation of the human body and internally registers the primordial yin and the primordial yang. Therefore, the kidney is the basis of the human body and plays an important role in various life activities of the human body; firstly, kidney stores essence, internally registers Yuan Ming Yuan Yang, Yuan Yin is the root of organism's essence, Yuan Yang is the root of human body's vitality, thus dominating the whole process of human growth and development and being closely related to human reproductive function. Secondly, kidneys governing water play an important role in the metabolism of body fluids.
In the prior art, a plurality of traditional Chinese medicine compositions for resisting fatigue exist, but generally adopt modes such as medicament and the like, and need to be brewed, and because each traditional Chinese medicine material is bitter and uncomfortable, and is not easy to be accepted by young people, and meanwhile, because the raw materials of the traditional Chinese medicine composition are mostly medicinal materials, after the traditional Chinese medicine composition is taken, if the traditional Chinese medicine composition cannot be timely supplemented with nutrition in the aspect of food, the human body cannot obtain effective efficacy, so that the human body is more weak.
Disclosure of Invention
In order to solve the problems, the invention provides an anti-fatigue traditional Chinese medicine composition tablet, which has pharmacological interaction among main medicines, has the efficacy effects of tonifying kidney and replenishing essence, nourishing liver and improving eyesight, tonifying spleen and benefiting lung, soothing nerves and benefiting intelligence, and can effectively relieve fatigue symptoms.
The invention also provides a preparation method of the traditional Chinese medicine composition tablet, which prepares the traditional Chinese medicine composition tablet by crushing, extracting, concentrating, granulating, tabletting and other modes, is easy to be absorbed by human body, gives full play to the good drug effect among main drugs, and further accelerates the achievement of the aim of relieving fatigue symptoms.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows.
An anti-fatigue traditional Chinese medicine composition tablet is prepared from the following main raw materials in parts by mass: 20-28 parts of mutton, 22-28 parts of semen cuscutae, 15-20 parts of herba epimedii, 6-10 parts of rhizoma curculiginis, 5-10 parts of cistanche, 5.5-8 parts of glossy privet fruit, 5.5-8 parts of schisandra chinensis, 5.5-8 parts of fructus alpiniae oxyphyllae, 3-5 parts of raspberry, 2.5-5 parts of rhizoma drynariae, 2.5-5 parts of parasitic loranthus, 5-8 parts of prepared rehmannia root, 3-5 parts of rhizoma polygonati, 3-5 parts of dendrobe, 2-5 parts of ginseng, 0.3-0.8 part of cornua cervi pantotrichum, 1-3 parts of astragalus membranaceus, 2-5 parts of codonopsis pilosula, 2-5 parts of phellodendron and 8.
Specifically, the traditional Chinese medicine composition tablet is prepared from the following main raw materials in parts by mass: 20-24 parts of mutton, 22-25 parts of semen cuscutae, 18-20 parts of herba epimedii, 8-10 parts of rhizoma curculiginis, 6-8 parts of cistanche, 7-8 parts of glossy privet fruit, 5.5-6.5 parts of schisandra chinensis, 6-7 parts of fructus alpiniae oxyphyllae, 4-5 parts of raspberry, 2.5-3 parts of rhizoma drynariae, 2.5-3 parts of parasitic loranthus, 7-8 parts of prepared rehmannia root, 4-5 parts of rhizoma polygonati, 3-4 parts of dendrobe, 4-5 parts of ginseng, 0.3-0.5 part of cornua cervi pantotrichum, 1-2 parts of astragalus membranaceus, 3-4 parts of codonopsis pilosula, 2-3 parts of phellodendron and 10.
Specifically, the traditional Chinese medicine composition tablet is also prepared from the following raw materials in parts by mass: 5-10 parts of kudzu root, 5-10 parts of poria cocos, 3-8 parts of Chinese date, 2-6 parts of dried orange peel, 2-6 parts of fructus amomi, 3-5 parts of rhizoma atractylodis, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of blighted wheat, 2-5 parts of arillus longan and 0.5-5 parts of dried ginger.
Specifically, the traditional Chinese medicine composition tablet is also prepared from the following raw materials in parts by mass: 8-10 parts of kudzu root, 8-10 parts of poria cocos, 3-4 parts of Chinese date, 2-4 parts of dried orange peel, 2-4 parts of fructus amomi, 3-5 parts of rhizoma atractylodis, 5-6 parts of bighead atractylodes rhizome, 6-8 parts of blighted wheat, 2-3 parts of arillus longan and 1-1.5 parts of dried ginger.
A method for preparing a Chinese medicinal composition tablet, comprising the anti-fatigue Chinese medicinal composition tablet of any one of claims 1-4, the method comprising the following steps:
s1, weighing 22-28 parts of semen cuscutae, 15-20 parts of herba epimedii, 6-10 parts of rhizoma curculiginis, 5-10 parts of herba cistanches, 5.5-8 parts of glossy privet fruit, 5.5-8 parts of schisandra chinensis, 5.5-8 parts of fructus alpiniae oxyphyllae, 3-5 parts of raspberry, 2.5-5 parts of rhizoma drynariae, 2.5-5 parts of parasitic loranthus, 5-8 parts of prepared rehmannia root, 3-5 parts of rhizoma polygonati, 3-5 parts of dendrobe, 2-5 parts of ginseng, 0.3-0.8 part of cornu cervi, 1-3 parts of astragalus membranaceus, 2-5 parts of codonopsis pilosula, 2-5 parts of golden cypress and 8-12 parts of wolfberry, cleaning, sterilizing, processing and drying, crushing after the drying step, sieving by a 1500-2000-mesh sieve, and mixing main medicines to obtain a main;
s2, weighing 5-10 parts of kudzu root, 5-10 parts of poria cocos, 3-8 parts of Chinese date, 2-6 parts of dried orange peel, 2-6 parts of fructus amomi, 3-5 parts of rhizoma atractylodis, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of blighted wheat, 2-5 parts of arillus longan and 0.5-5 parts of dried ginger, cleaning, sterilizing, processing and drying, crushing after the drying step, sieving with a sieve of 80-120 meshes after crushing, and screening and mixing to obtain fine powder of the auxiliary traditional Chinese medicine;
s3, weighing 20-28 parts of mutton, cleaning, mincing into mutton puree, adding 1-2 times of clean water by weight of the mutton puree, uniformly mixing, and heating at low temperature for 2-3 hours to obtain mutton liquid;
s4, adding clean water in an amount which is 3-5 times the weight of the main medicine powder in the step S1, heating and boiling for 2-3 times, extracting for 2-3 hours each time, and combining the extracting solutions to obtain a main medicine extracting solution;
s5, uniformly mixing the mutton liquid and the main drug extract in the steps S3 and S4, and concentrating under reduced pressure at the temperature of 60-70 ℃ to obtain a main drug concentrated solution;
s6, uniformly mixing the concentrated solution of the main drug in the step S5 and the fine powder of the auxiliary drug in the step S2, drying, crushing, sieving by a 100-150-mesh sieve, and screening to obtain dry particles of the traditional Chinese medicine composition;
and S7, feeding the dry traditional Chinese medicine composition granules obtained in the step S6 into a tablet press for tabletting to obtain the traditional Chinese medicine composition tablets.
Specifically, the water content of the dry particles of the traditional Chinese medicine composition in the step S6 is controlled within the range of 3-5%.
Specifically, in step S3, the low-temperature heating temperature range is 50 to 60 ℃.
Specifically, in step S5, the relative density of the concentrated solution of the concentrated main drug is 1.2g/cm3～1.4g/cm3。
Specifically, the weight of each tablet of the traditional Chinese medicine composition tablet obtained in the step S7 is 0.15g-0.8 g.
The invention has the beneficial effects that: the traditional Chinese medicine composition tablet belongs to a medicine-food homologous product, can improve immunity and relieve fatigue symptoms, and has no toxic or side effect; the traditional Chinese medicine composition tablet takes mutton, dodder, epimedium herb, common curculigo rhizome, desertliving cistanche, glossy privet fruit, Chinese magnoliavine fruit, sharpleaf galangal fruit, raspberry, fortune's drynaria rhizome, Chinese taxillus twig, prepared rehmannia root, manyflower solomonseal rhizome, dendrobium, ginseng, pilose antler, astragalus mongholicus, codonopsis pilosula, amur corktree bark, barbary wolfberry fruit and the like as main medicines, and the main medicines have pharmacological interaction, so that the traditional Chinese medicine composition tablet has the efficacy of tonifying kidney, boosting essence, nourishing liver, improving eyesight, tonifying spleen, boosting; mutton is one of the main drugs, interacts with other main drugs to warm and replenish qi and blood, and provides a certain amount of protein fiber, so that a user can obtain certain nutrition supplement and exert better drug effect; the traditional Chinese medicine composition tablet takes kudzu root, tuckahoe, Chinese date, dried orange peel, fructus amomi, rhizoma atractylodis, bighead atractylodes rhizome, light wheat, longan pulp, dried ginger and the like as auxiliary medicines, takes the effects of nourishing liver and improving eyesight, tonifying spleen and benefiting lung, soothing nerves and improving intelligence of the main medicines, relieves fatigue symptoms and also has the function of improving taste, and is beneficial to preparing the composition tablet because the auxiliary medicines contain more starch components.
The preparation method of the traditional Chinese medicine composition tablet comprises the steps of obtaining a main medicine extracting solution and a mutton liquid, mixing, decompressing and concentrating to obtain a main medicine concentrated solution, effectively retaining the nutrient components of the mutton by heating the mutton at low temperature, adding an auxiliary medicine fine powder obtained by crushing the auxiliary medicine, mixing and drying to obtain a traditional Chinese medicine composition dry particle, and pressing the traditional Chinese medicine composition dry particle to obtain the traditional Chinese medicine composition tablet; the traditional Chinese medicine composition tablet prepared by the preparation method through the modes of crushing, extracting, concentrating, granulating, tabletting and the like is easy to be absorbed by human bodies, gives full play to the good drug effect among main drugs, and further accelerates the achievement of the purpose of relieving fatigue symptoms.
Detailed Description
The present invention will be described in further detail with reference to the following embodiments. The present application may be embodied in many different forms and is not limited to the embodiments described in the present embodiment.
The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.
The materials, components and the like used in the embodiment of the invention are all loaded in national legal standards, and can be obtained from commercial approaches if no special description is provided.
The basic conditions of the main raw material medicines are introduced in the following parts according to Chinese pharmacopoeia, Chinese dictionary, Chinese herbage, Chinese herbal compilation and the like.
Dodder seed: sweet and pungent in flavor and slightly warm in nature. It enters liver, kidney and spleen meridians. Tonify kidney, replenish essence, nourish liver to improve vision, prevent miscarriage, improve vision, check diarrhea, secure essence and reduce urination.
Herba epimedii: pungent, sweet and warm in nature. It enters liver and kidney meridians. The functional indications are as follows: tonify kidney yang, strengthen tendons and bones, dispel wind-damp, and are commonly indicated for impotence, seminal emission, flaccidity of tendons and bones, wind-damp arthralgia, numbness, spasm, climacteric hypertension, etc.
Mutton: sweet and warm in nature and taste. Tonifying deficiency, dispelling cold, warming and invigorating qi and blood; tonifying kidney qi, tonifying body, stimulating appetite, and strengthening body constitution; tonify the parturient, promote lactation to treat leukorrhagia, strengthen primordial yang, and nourish essence and blood.
Ginseng: sweet, slightly bitter and neutral in nature and taste. It enters spleen, lung and heart meridians. The functions are mainly used for reinforcing primordial qi, restoring pulse, relieving depletion, tonifying spleen, benefiting lung, promoting the production of body fluid, quenching thirst, calming nerves and improving intelligence. Has effects of invigorating primordial qi, invigorating spleen, benefiting lung, promoting fluid production, tranquilizing mind, and improving intelligence. It is mainly indicated for qi deficiency syndrome, qi deficiency syndrome of lung, spleen, heart and kidney, thirst due to deficiency of heat and body fluid, and syndrome of exogenous qi deficiency or excess heat accumulation in the interior to cause excess and deficiency of healthy qi.
Pilose antler: sweet, salty and warm in nature and taste. It enters kidney and liver meridians. The functions are mainly used for strengthening kidney yang, benefiting essence and blood, strengthening muscles and bones, regulating thoroughfare and conception vessels and supporting sore toxin. Can be used for treating sexual impotence, spermatorrhea, infertility due to cold womb, emaciation, listlessness, intolerance of cold, vertigo, tinnitus, deafness, cold and pain of waist and back, tendons and bones flaccidity, metrorrhagia, leukorrhagia, and dorsal furuncle.
Wolfberry fruit, fructus Lycii, sweet in nature and taste. It enters liver and kidney meridians. The functional indications are as follows: nourishing liver and kidney, replenishing vital essence and improving eyesight. Can be used for treating asthenia, soreness of waist and knees, vertigo, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion, and blurred vision.
Xian Mao is pungent in flavor and hot in nature. Contains tannin, fat, resin, starch, etc. Warming kidney yang, strengthening tendons and bones. It can be used for treating sexual impotence, spermatorrhea, urinary incontinence, metrorrhagia, heart and abdomen psychroalgia, lumbago, foot arthralgia, superficial infection, lymphoid tuberculosis, yang deficiency, and diarrhea.
Cistanche deserticola has the effects of tonifying kidney and yang, moistening intestines and relaxing bowels, has sweet taste and can tonify, sweet warm and yang-tonifying, moistening and nourishing, and salty taste enters kidney, and is a good medicine for tonifying kidney yang and benefiting essence and blood.
The glossy privet fruit is sweet, bitter and cool in nature and has the effects of tonifying liver and kidney, strengthening waist and knees, improving eyesight and ears and blackening beard and hair.
Schisandra chinensis: sour, sweet and warm in nature. It enters lung, heart and kidney meridians. The functions are mainly used for astringing and inducing astringency, tonifying qi and promoting the production of body fluid, tonifying the kidney and calming the heart. Can be used for treating chronic cough, asthma, nocturnal emission, enuresis, frequent micturition, chronic diarrhea, spontaneous perspiration, night sweat, thirst due to body fluid consumption, short breath, weak pulse, internal heat, diabetes, palpitation, and insomnia.
Example 1: the preparation method of the traditional Chinese medicine composition tablet 1 comprises the following steps:
s1, weighing 22 parts of semen cuscutae, 15 parts of herba epimedii, 6 parts of rhizoma curculiginis, 5 parts of herba cistanche, 5.5 parts of glossy privet fruit, 5.5 parts of schisandra chinensis, 5.5 parts of fructus alpiniae oxyphyllae, 3 parts of raspberry, 2.5 parts of rhizoma drynariae, 2.5 parts of loranthus parasiticus, 5 parts of prepared rehmannia root, 3 parts of rhizoma polygonati, 3 parts of dendrobe, 2 parts of ginseng, 0.3 part of pilose antler, 1-part of astragalus membranaceus, 2 parts of codonopsis pilosula, 2 parts of cortex phellodendri and 8 parts of wolfberry fruit, cleaning, sterilizing, processing and drying, crushing after the drying step, sieving by a 1500-2000-mesh sieve, and mixing to obtain the main medicine coarse.
S2, weighing 5 parts of kudzu root, 5 parts of poria cocos, 3 parts of Chinese date, 3 parts of dried orange peel, 2 parts of fructus amomi, 3 parts of rhizoma atractylodis, 5 parts of rhizoma atractylodis macrocephalae, 5 parts of blighted wheat, 2 parts of arillus longan and 0.5 part of dried ginger, cleaning, sterilizing, processing and drying, crushing after the drying step, sieving by a sieve of 80-120 meshes, screening and mixing to obtain the fine powder of the auxiliary traditional Chinese medicine.
S3, weighing 20 parts of mutton, cleaning, mincing into mutton paste, adding 1-2 times of clean water by weight of the mutton paste, uniformly mixing, and heating at low temperature for 2-3 hours to obtain mutton liquid; the temperature range for low temperature heating is 50 ℃.
S4, taking the main drug powder in the step S1, adding 3-5 times of clean water by weight of the main drug powder, heating and boiling for 2-3 times, extracting for 2-3 hours each time, and combining the extracting solutions to obtain a main drug extracting solution.
S5, uniformly mixing the mutton liquid and the main drug extract in the steps S3 and S4, and concentrating under reduced pressure at the temperature of 60-70 ℃ to obtain a main drug concentrated solution; the relative density of concentrated liquid phase of the concentrated main drug is 1.4g/cm3。
S6, uniformly mixing the concentrated solution of the main drug in the step S5 and the fine powder of the auxiliary drug in the step S2, drying, crushing, sieving by a 100-150-mesh sieve, and screening to obtain dry particles of the traditional Chinese medicine composition; the water content of the dry particles of the traditional Chinese medicine composition is controlled within 3 percent.
S7, feeding the dry Chinese medicinal composition granules obtained in the step S6 into a tabletting machine for tabletting to obtain a Chinese medicinal composition tablet 1; the weight of each tablet of the obtained Chinese medicinal composition tablet is 0.3 g.
Example 2 preparation of a Chinese medicinal composition tablet 2, the steps are as follows:
s1, weighing 25 parts of semen cuscutae, 18 parts of herba epimedii, 8 parts of rhizoma curculiginis, 8 parts of herba cistanche, 7 parts of glossy privet fruit, 6.5 parts of schisandra chinensis, 6 parts of fructus alpiniae oxyphyllae, 4 parts of raspberry, 3 parts of rhizoma drynariae, 3 parts of loranthus parasiticus, 7 parts of prepared rehmannia root, 4 parts of rhizoma polygonati, 4 parts of dendrobe, 4 parts of ginseng, 0.5 part of pilose antler, 2 parts of astragalus mongholicus, 4 parts of codonopsis pilosula, 3 parts of golden cypress and 10 parts of wolfberry fruit, cleaning, sterilizing, processing and drying, crushing after the drying step, sieving by a 1500-2000-mesh sieve for screening and mixing to obtain main medicine coarse powder.
S2, weighing 8 parts of kudzu root, 8 parts of poria cocos, 4 parts of Chinese date, 4 parts of dried orange peel, 4 parts of fructus amomi, 3 parts of rhizoma atractylodis, 6 parts of rhizoma atractylodis macrocephalae, 6 parts of blighted wheat, 3 parts of arillus longan and 1.5 parts of dried ginger, cleaning, sterilizing, processing and drying, crushing after the drying step, sieving by a sieve of 80-120 meshes, screening and mixing to obtain the fine powder of the auxiliary traditional Chinese medicine.
S3, weighing 24 parts of mutton, cleaning, mincing into mutton puree, adding 1-2 times of clean water by weight of the mutton puree, uniformly mixing, and heating at low temperature for 2-3 hours to obtain mutton liquid; the temperature range for low temperature heating was 55 ℃.
S4, taking the main drug powder in the step S1, adding 3-5 times of clean water by weight of the main drug powder, heating and boiling for 2-3 times, extracting for 2-3 hours each time, and combining the extracting solutions to obtain a main drug extracting solution.
S5, uniformly mixing the mutton liquid and the main drug extract in the steps S3 and S4, and concentrating under reduced pressure at the temperature of 60-70 ℃ to obtain a main drug concentrated solution; the relative density of concentrated liquid phase of the concentrated main drug is 1.3g/cm3。
S6, uniformly mixing the concentrated solution of the main drug in the step S5 and the fine powder of the auxiliary drug in the step S2, drying, crushing, sieving by a 100-150-mesh sieve, and screening to obtain dry particles of the traditional Chinese medicine composition; the water content of the dry particles of the traditional Chinese medicine composition is controlled within the range of 4 percent.
S7, feeding the dry Chinese medicinal composition granules obtained in the step S6 into a tabletting machine for tabletting to obtain the Chinese medicinal composition tabletting 2, wherein the weight of each tablet of the Chinese medicinal composition tabletting 2 is 0.5 g.
Example 3: the preparation of the Chinese medicinal composition tablet 3 comprises the following steps:
s1, weighing 28 parts of semen cuscutae, 20 parts of herba epimedii, 10 parts of rhizoma curculiginis, 10 parts of herba cistanche, 8 parts of glossy privet fruit, 8 parts of schisandra chinensis, 8 parts of fructus alpiniae oxyphyllae, 5 parts of raspberry, 5 parts of rhizoma drynariae, 5 parts of parasitic loranthus, 8 parts of prepared rehmannia root, 5 parts of rhizoma polygonati, 5 parts of dendrobe, 5 parts of ginseng, 0.8 part of cornu cervi pantotrichum, 3 parts of radix astragali, 5 parts of codonopsis pilosula, 5 parts of golden cypress and 12 parts of wolfberry fruit, cleaning, sterilizing, processing and drying, crushing after the drying step, sieving with a 1500-2000-mesh sieve, screening and mixing to obtain main medicine coarse.
S2, weighing 10 parts of kudzu root, 10 parts of poria cocos, 6 parts of Chinese date, 4 parts of dried orange peel, 4 parts of fructus amomi, 5 parts of rhizoma atractylodis, 10 parts of rhizoma atractylodis macrocephalae, 10 parts of blighted wheat, 4 parts of arillus longan and 2 parts of dried ginger, cleaning, sterilizing, processing and drying, crushing after the drying step, sieving by a 80-120-mesh sieve, and screening and mixing to obtain the auxiliary traditional Chinese medicine fine powder.
S3, weighing 28 parts of mutton, cleaning, mincing into mutton paste, adding 1-2 times of clean water by weight of the mutton paste, uniformly mixing, and heating at low temperature for 2-3 hours to obtain mutton liquid.
S4, taking the main drug powder in the step S1, adding 3-5 times of clean water by weight of the main drug powder, heating and boiling for 2-3 times, extracting for 2-3 hours each time, and combining the extracting solutions to obtain a main drug extracting solution.
S5, uniformly mixing the mutton liquid and the main drug extract in the steps S3 and S4, and concentrating under reduced pressure at the temperature of 60-70 ℃ to obtain a main drug concentrated solution; the relative density of concentrated liquid phase of the concentrated main drug is 1.2g/cm3。
S6, uniformly mixing the concentrated solution of the main drug in the step S5 and the fine powder of the auxiliary drug in the step S2, drying, crushing, sieving by a 100-150-mesh sieve, and screening to obtain dry particles of the traditional Chinese medicine composition; the water content of the Chinese medicinal composition dry granules is controlled within 5%.
S7, feeding the dry Chinese medicinal composition granules obtained in the step S6 into a tabletting machine for tabletting to obtain a Chinese medicinal composition tablet 3; the weight of each tablet of the obtained Chinese medicinal composition tablet is 0.8 g.
The embodiments of the Chinese medicinal composition tabletting of the invention are applied to clinic, and the treatment effect is as follows:
1. basic data: 15 cases of testers are collected; test group 1 to test group 3, 5 cases each.
2. Evaluation indexes are as follows: (1) symptoms of fatigue: the fatigue scale 14(fatigue scale-14, FS-14) was used to evaluate the patient's symptoms of fatigue. The scale is compiled by trudifchalder and g.bergelowitz, etc. and is used for evaluating the type and severity of fatigue. The total number of the items is 14, wherein 1-8 items reflect physical fatigue; items 9-14 reflect mental fatigue. According to whether the content of the test object accords with the actual situation of the test object or not, the 'yes' person is counted as '1' score, and the 'no' person is counted as '0' score; wherein the items 10, 13 and 14 are reverse scores, namely, the item with the score of "yes" is counted as the score of "0", and the item with the score of "1" is counted as the item with the score of "no"; the total score is 0-14. (2) The syndrome of traditional Chinese medicine: according to the guideline of clinical research of new Chinese medicine, the evaluation of the Chinese medicine symptom integral evaluation table of spleen-kidney yang deficiency syndrome is adopted. The scale comprises 2 aspects of major symptoms and minor symptoms, wherein the major symptoms comprise 5 items of evaluation of lassitude, hypodynamia, chilly, cold limbs, short breath, no speaking desire, anorexia and soreness and weakness of waist and knees, and a four-stage scoring method of 0, 2, 4 and 6 is adopted; the secondary symptoms comprise 4 items of evaluation of cold pain in the waist, abdominal fullness and distention, constipation and nocturia and urine retention, and a four-grade scoring method of 0, 1, 2 and 3 points is adopted. The score range is 0-42 points, and the higher the score is, the more serious the traditional Chinese medicine syndrome is prompted.
3. The treatment method and the treatment course are as follows: test groups 1-3 are administered with the Chinese medicinal composition of examples 1-3 respectively, 3-5g each time, 2 times per day, 1 week for 1 treatment course, and 3-5 treatment courses.
4. Criteria for judging therapeutic effects
The testers periodically carry out test statistics on the fatigue symptom scores and the traditional Chinese medicine syndrome scores every week within 1 month before taking the medicine, and the external conditions (such as diet aspects) are kept the same; periodically carrying out test statistics on fatigue symptom scores and Chinese medicine syndrome scores every week within 1 month after the medicine is taken, and keeping the external conditions (such as diet) the same; comparing the fatigue symptom scores before and after the fatigue symptom scores with the traditional Chinese medicine syndrome scores, judging the comprehensive curative effect, and dividing the curative effect judgment standard into 3 grades of obvious effect, effective effect and ineffective effect. Wherein, the effect is shown: the fatigue symptom score and the Chinese medicine syndrome score are both reduced by more than or equal to 80 percent; the method has the following advantages: the fatigue symptom score and the Chinese medicine syndrome score are both reduced by more than or equal to 50 percent; and (4) invalidation: the fatigue symptom score and/or the Chinese medicine syndrome score are/is reduced by less than 20 percent.
5. Therapeutic results
The clinical test shows that the traditional Chinese medicine composition has a relatively obvious effect on resisting fatigue, for example, the fatigue state can be effectively reduced by more than 50% after long-term administration, and adverse reaction patients are not discovered temporarily in adverse reaction observation.
The above embodiments are merely illustrative of the preferred embodiments of the present invention, and not restrictive, and various changes and modifications to the technical solutions of the present invention may be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are intended to fall within the scope of the present invention defined by the appended claims.
Claims (9)
1. An anti-fatigue traditional Chinese medicine composition tablet is characterized in that: the traditional Chinese medicine composition tablet is prepared from the following main raw materials in parts by mass: 20-28 parts of mutton, 22-28 parts of semen cuscutae, 15-20 parts of herba epimedii, 6-10 parts of rhizoma curculiginis, 5-10 parts of cistanche, 5.5-8 parts of glossy privet fruit, 5.5-8 parts of schisandra chinensis, 5.5-8 parts of fructus alpiniae oxyphyllae, 3-5 parts of raspberry, 2.5-5 parts of rhizoma drynariae, 2.5-5 parts of parasitic loranthus, 5-8 parts of prepared rehmannia root, 3-5 parts of rhizoma polygonati, 3-5 parts of dendrobe, 2-5 parts of ginseng, 0.3-0.8 part of cornua cervi pantotrichum, 1-3 parts of astragalus membranaceus, 2-5 parts of codonopsis pilosula, 2-5 parts of golden cypress and 8.
2. The anti-fatigue traditional Chinese medicine composition tablet according to claim 1, which is characterized in that: the traditional Chinese medicine composition tablet is prepared from the following main raw materials in parts by mass: 20-24 parts of mutton, 22-25 parts of semen cuscutae, 18-20 parts of herba epimedii, 8-10 parts of rhizoma curculiginis, 6-8 parts of cistanche, 7-8 parts of glossy privet fruit, 5.5-6.5 parts of schisandra chinensis, 6-7 parts of fructus alpiniae oxyphyllae, 4-5 parts of raspberry, 2.5-3 parts of rhizoma drynariae, 2.5-3 parts of parasitic loranthus, 7-8 parts of prepared rehmannia root, 4-5 parts of rhizoma polygonati, 3-4 parts of dendrobe, 4-5 parts of ginseng, 0.3-0.5 part of cornua cervi pantotrichum, 1-2 parts of astragalus membranaceus, 3-4 parts of codonopsis pilosula, 2-3 parts of phellodendron and 10.
3. The anti-fatigue traditional Chinese medicine composition tablet according to claim 1, which is characterized in that: the traditional Chinese medicine composition tablet is also prepared from the following raw materials in parts by mass: 5-10 parts of kudzu root, 5-10 parts of poria cocos, 3-8 parts of Chinese date, 2-6 parts of dried orange peel, 2-6 parts of fructus amomi, 3-5 parts of rhizoma atractylodis, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of blighted wheat, 2-5 parts of arillus longan and 0.5-5 parts of dried ginger.
4. The anti-fatigue traditional Chinese medicine composition tablet according to claim 3, which is characterized in that: the traditional Chinese medicine composition tablet is also prepared from the following raw materials in parts by mass: 8-10 parts of kudzu root, 8-10 parts of poria cocos, 3-4 parts of Chinese date, 2-4 parts of dried orange peel, 2-4 parts of fructus amomi, 3-5 parts of rhizoma atractylodis, 5-6 parts of bighead atractylodes rhizome, 6-8 parts of blighted wheat, 2-3 parts of arillus longan and 1-1.5 parts of dried ginger.
5. A preparation method of a traditional Chinese medicine composition tablet is characterized by comprising the following steps: the anti-fatigue traditional Chinese medicine composition tablet as claimed in any one of claims 1 to 4, which is prepared by the following steps:
s1, weighing 22-28 parts of semen cuscutae, 15-20 parts of herba epimedii, 6-10 parts of rhizoma curculiginis, 5-10 parts of herba cistanches, 5.5-8 parts of glossy privet fruit, 5.5-8 parts of schisandra chinensis, 5.5-8 parts of fructus alpiniae oxyphyllae, 3-5 parts of raspberry, 2.5-5 parts of rhizoma drynariae, 2.5-5 parts of parasitic loranthus, 5-8 parts of prepared rehmannia root, 3-5 parts of rhizoma polygonati, 3-5 parts of dendrobe, 2-5 parts of ginseng, 0.3-0.8 part of cornu cervi, 1-3 parts of astragalus membranaceus, 2-5 parts of codonopsis pilosula, 2-5 parts of golden cypress and 8-12 parts of wolfberry, cleaning, sterilizing, processing and drying, crushing after the drying step, sieving by a 1500-2000-mesh sieve, and mixing main medicines to obtain a main;
s2, weighing 5-10 parts of kudzu root, 5-10 parts of poria cocos, 3-8 parts of Chinese date, 2-6 parts of dried orange peel, 2-6 parts of fructus amomi, 3-5 parts of rhizoma atractylodis, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of blighted wheat, 2-5 parts of arillus longan and 0.5-5 parts of dried ginger, cleaning, sterilizing, processing and drying, crushing after the drying step, sieving with a sieve of 80-120 meshes after crushing, and screening and mixing to obtain fine powder of the auxiliary traditional Chinese medicine;
s3, weighing 20-28 parts of mutton, cleaning, mincing into mutton puree, adding 1-2 times of clean water by weight of the mutton puree, uniformly mixing, and heating at low temperature for 2-3 hours to obtain mutton liquid;
s4, adding clean water in an amount which is 3-5 times the weight of the main medicine powder in the step S1, heating and boiling for 2-3 times, extracting for 2-3 hours each time, and combining the extracting solutions to obtain a main medicine extracting solution;
s5, uniformly mixing the mutton liquid and the main drug extract in the steps S3 and S4, and concentrating under reduced pressure at the temperature of 60-70 ℃ to obtain a main drug concentrated solution;
s6, uniformly mixing the concentrated solution of the main drug in the step S5 and the fine powder of the auxiliary drug in the step S2, drying, crushing, sieving by a 100-150-mesh sieve, and screening to obtain dry particles of the traditional Chinese medicine composition;
s7, feeding the dry Chinese medicinal composition granules obtained in the step S6 into a tabletting machine for tabletting to obtain the Chinese medicinal composition tablets.
6. The method for preparing a compressed tablet of a Chinese medicinal composition according to claim 5, wherein the compressed tablet of a Chinese medicinal composition comprises: the water content of the dry particles of the traditional Chinese medicine composition in the step S6 is controlled within the range of 3-5%.
7. The method for preparing a compressed tablet of a Chinese medicinal composition according to claim 5, wherein the compressed tablet of a Chinese medicinal composition comprises: in step S3, the low-temperature heating temperature range is 50 ℃ to 60 ℃.
8. The method for preparing a compressed tablet of a Chinese medicinal composition according to claim 5, wherein the compressed tablet of a Chinese medicinal composition comprises: in step S5, the concentrated solution of the concentrated main drug has a relative density of 1.2g/cm3～1.4g/cm3。
9. The method for preparing a compressed tablet of a Chinese medicinal composition according to claim 5, wherein the compressed tablet of a Chinese medicinal composition comprises: the weight of each tablet of the Chinese medicinal composition tablet obtained in the step S7 is 0.15g-0.8 g.
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| CN111617153A (en) * | 2020-07-01 | 2020-09-04 | 郭振彪 | Traditional Chinese medicine composition for tonifying consumptive disease and strengthening primordial yang and preparation and application thereof |
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| CN102258734A (en) * | 2011-07-18 | 2011-11-30 | 淮安市楚州区古神梅花鹿养殖场 | Cartialgenous wine having antifatigue and immunity-regulating effects and preparation method thereof |
| CN111617153A (en) * | 2020-07-01 | 2020-09-04 | 郭振彪 | Traditional Chinese medicine composition for tonifying consumptive disease and strengthening primordial yang and preparation and application thereof |
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