CN112041447A - 基质金属蛋白酶-1反义寡核苷酸 - Google Patents

基质金属蛋白酶-1反义寡核苷酸 Download PDF

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Publication number
CN112041447A
CN112041447A CN201980026668.4A CN201980026668A CN112041447A CN 112041447 A CN112041447 A CN 112041447A CN 201980026668 A CN201980026668 A CN 201980026668A CN 112041447 A CN112041447 A CN 112041447A
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substituted
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group
formula
peptide nucleic
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Chinese (zh)
Inventor
韩璿瑛
成基浩
洪铭涍
吴有利
许情奭
张降愿
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OliPass Corp
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OliPass Corp
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
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    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
    • C—CHEMISTRY; METALLURGY
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
CN201980026668.4A 2018-05-18 2019-05-03 基质金属蛋白酶-1反义寡核苷酸 Pending CN112041447A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2018-0057352 2018-05-18
KR20180057352 2018-05-18
PCT/KR2019/005994 WO2019221570A1 (en) 2018-05-18 2019-05-03 Matrix metalloproteinase-1 antisense oligonucleotides

Publications (1)

Publication Number Publication Date
CN112041447A true CN112041447A (zh) 2020-12-04

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CN201980026668.4A Pending CN112041447A (zh) 2018-05-18 2019-05-03 基质金属蛋白酶-1反义寡核苷酸

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Country Link
US (1) US20210292369A1 (ja)
EP (1) EP3794124A4 (ja)
JP (1) JP7422406B2 (ja)
KR (1) KR102194594B1 (ja)
CN (1) CN112041447A (ja)
AR (1) AR114533A1 (ja)
AU (1) AU2019268955A1 (ja)
BR (1) BR112020017892A2 (ja)
CA (1) CA3091911A1 (ja)
MX (1) MX2020009836A (ja)
SG (1) SG11202008247WA (ja)
TW (1) TWI832851B (ja)
WO (1) WO2019221570A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102304280B1 (ko) 2018-08-14 2021-09-23 올리패스 주식회사 아세틸코에이카복실라제2 안티센스 올리고뉴클레오티드

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105044A1 (en) * 2001-10-17 2003-06-05 Isis Pharmaceuticals Inc. Antisense modulation of matrix metalloproteinase 1 expression
US6617422B1 (en) * 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
CN101579529A (zh) * 2003-09-29 2009-11-18 托皮根药品公司 治疗包括炎症状况的疾病的寡核苷酸组合物和方法
US20110178031A1 (en) * 2008-03-14 2011-07-21 Cti Bio Peptide nucleic acid derivatives with good cell penetration and strong affinity for nucleic acid
WO2018029517A1 (en) * 2016-08-08 2018-02-15 Olipass Corporation Androgen receptor antisense oligonucleotides
WO2018051175A1 (en) * 2016-09-16 2018-03-22 Olipass Corporation Scn9a antisense oligonucleotides
WO2018069764A1 (en) * 2016-10-11 2018-04-19 Olipass Corporation Hif 1-alpha antisense oligonucleotides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077384A2 (de) * 2000-04-07 2001-10-18 Epigenomics Ag DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN
DE10238298A1 (de) * 2002-08-21 2004-03-04 Beiersdorf Ag Verwendung von Antisense-Oligonucleotiden zur Behandlung von degenerativen Hauterscheinungen
WO2006088483A2 (en) * 2004-06-16 2006-08-24 Trustees Of Dartmouth College Compositions and methods for inhibiting the synthesis or expression of mmp-1
KR20120073536A (ko) * 2010-12-27 2012-07-05 주식회사 파나진 다중전하를 갖는 ｐｎａ
US20150240239A1 (en) * 2014-02-27 2015-08-27 Nugen Biosience (Taiwan) Co., Ltd. Methods and pharmaceutical compositions for inhibiting matrix metalloproteinases 1 by interference ribonucleic acid
EP3188799B1 (en) * 2014-09-05 2022-07-06 Phio Pharmaceuticals Corp. Methods for treating aging and skin disorders using nucleic acids targeting tyr or mmp1
AU2017385962B2 (en) * 2016-12-30 2021-09-02 Olipass Corporation Exon skipping by peptide nucleic acid derivatives

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6617422B1 (en) * 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
US20030105044A1 (en) * 2001-10-17 2003-06-05 Isis Pharmaceuticals Inc. Antisense modulation of matrix metalloproteinase 1 expression
CN101579529A (zh) * 2003-09-29 2009-11-18 托皮根药品公司 治疗包括炎症状况的疾病的寡核苷酸组合物和方法
US20110178031A1 (en) * 2008-03-14 2011-07-21 Cti Bio Peptide nucleic acid derivatives with good cell penetration and strong affinity for nucleic acid
WO2018029517A1 (en) * 2016-08-08 2018-02-15 Olipass Corporation Androgen receptor antisense oligonucleotides
WO2018051175A1 (en) * 2016-09-16 2018-03-22 Olipass Corporation Scn9a antisense oligonucleotides
WO2018069764A1 (en) * 2016-10-11 2018-04-19 Olipass Corporation Hif 1-alpha antisense oligonucleotides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
VERA KNA È UPER等: "The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity", 《EUR. J. BIOCHEM.》, vol. 268, pages 1894 *
YOUNG IN LEE等: "Topical Application of Peptide Nucleic Acid Antisense Oligonucleotide for MMP-1 and Its Potential Anti-Aging Properties", 《JOURNAL OF CLINICAL MEDICINE》, vol. 12, pages 1 - 13 *
陈佳等: "STAT3反义寡核苷酸对乳腺癌MCF-7细胞增殖和凋亡的影响", 《肿瘤防治研究》, vol. 37, no. 03, pages 263 - 265 *

Also Published As

Publication number Publication date
JP7422406B2 (ja) 2024-01-26
EP3794124A1 (en) 2021-03-24
MX2020009836A (es) 2021-01-08
TWI832851B (zh) 2024-02-21
SG11202008247WA (en) 2020-12-30
KR20190132220A (ko) 2019-11-27
CA3091911A1 (en) 2019-11-21
AR114533A1 (es) 2020-09-16
TW202002991A (zh) 2020-01-16
US20210292369A1 (en) 2021-09-23
KR102194594B1 (ko) 2020-12-23
EP3794124A4 (en) 2022-08-10
JP2021524236A (ja) 2021-09-13
AU2019268955A1 (en) 2020-11-26
BR112020017892A2 (pt) 2020-12-22
WO2019221570A1 (en) 2019-11-21

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